LOCUS NZ_JARDXE010000006 25185 bp DNA linear CON 01-APR-2024 DEFINITION Rhodococcus qingshengii strain HQ HQ1_scaffold6, whole genome shotgun sequence. ACCESSION NZ_JARDXE010000006 VERSION NZ_JARDXE010000006.1 KEYWORDS WGS; RefSeq. SOURCE Rhodococcus qingshengii ORGANISM Rhodococcus qingshengii Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae; Rhodococcus; Rhodococcus erythropolis group. REFERENCE 1 (bases 1 to 322110) AUTHORS Hu,J. and Xu,J. TITLE A novel hydrolase synthesized by Rhodococcus erythropolis HQ is responsible for the detoxification of Zearalenone JOURNAL Unpublished REFERENCE 2 (bases 1 to 322110) AUTHORS Hu,J. and Xu,J. TITLE Direct Submission JOURNAL Submitted (23-FEB-2023) Grain and Oil Risk Assessment Laboratory, Jiangsu Academy of Agricultural Sciences, No. 50, Zhongling Street, nanjing 210014, China COMMENT ##Genome-Assembly-Data-START## Assembly Date :: MAY-2022 Assembly Method :: ABySS v. 2.1.5 Genome Representation :: Full Expected Final Version :: Yes Reference-guided Assembly :: GCA_002079265.1 Genome Coverage :: 470.0x Sequencing Technology :: Illumina NovaSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_029076895.1-RS_2024_04_01 Annotation Date :: 04/01/2024 06:35:53 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,927 CDSs (total) :: 6,855 Genes (coding) :: 6,768 CDSs (with protein) :: 6,768 Genes (RNA) :: 72 rRNAs :: 1, 1, 1 (5S, 16S, 23S) complete rRNAs :: 1, 1, 1 (5S, 16S, 23S) tRNAs :: 66 ncRNAs :: 3 Pseudo Genes (total) :: 87 CDSs (without protein) :: 87 Pseudo Genes (ambiguous residues) :: 0 of 87 Pseudo Genes (frameshifted) :: 33 of 87 Pseudo Genes (incomplete) :: 63 of 87 Pseudo Genes (internal stop) :: 12 of 87 Pseudo Genes (multiple problems) :: 18 of 87 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 19:34:22 NOTE :: This is a single region extracted from a larger record! Orig. start :: 296925 Orig. end :: 322110 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to JARDXE010000006.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..25185 /candidate_cluster_numbers="1" /contig_edge="True" /product="T1PKS" /region_number="2" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /tool="antismash" cand_cluster 1..25185 /SMILES="C([*])C(-O)" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="single" /product="T1PKS" /protoclusters="1" /tool="antismash" protocluster 1..25185 /aStool="rule-based-clusters" /category="PKS" /contig_edge="True" /core_location="[20000:24950](-)" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" /tool="antismash" proto_core complement(20001..24950) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" gene 319..1752 /locus_tag="PXH69_RS11910" /old_locus_tag="PXH69_11905" CDS 319..1752 /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1261: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005253221.1" /locus_tag="PXH69_RS11910" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11905" /product="FAD-binding oxidoreductase" /protein_id="WP_003943934.1" /transl_table=11 /translation="MSTTAEETPQPALHTQARTLTGWGRTAATTAQVLSTPDVEVIANA VAQVAEQNDSKPSHLRRGVIARGLGRSYGDPAQNAGGLVIDMNALSRIHRIDRDTALVD VDAGVNLDQLMKAALPFGLWVPVLPGTRQVTIGGAIGSDIHGKNHHSAGSFGNHVVSLD LLTADGKVRTLTPKGGRNDPKAALFWATIGGMGLTGIILRATIKMTPTETAYFIADGDV TNSLDETIALHSDGSEANYEYSSAWFDAISAPPKLGRAAVSRGSLAKLDQLPAKLQKNP LAFDAPQLLTFPDVFPNGLANKFNFTAIGEVWFRKSGKYRGKVQNLTQFYHPLDMFGEW NRAYGSNGFLQYQFVVPPEAVDEFKKIIVDIQRSGHYSFLNVFKLFGEGNQAPLSFPIP GWNICVDFRIKPGLNEFVTELDKRVLEFGGRLYTAKDSRTSAETFHAMYPRIDEWIATR RKYDPTGVFASDMSRRLEL" gene 1749..2510 /locus_tag="PXH69_RS11915" /old_locus_tag="PXH69_11910" CDS 1749..2510 /EC_number="1.1.1.333" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943826.1" /locus_tag="PXH69_RS11915" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11910" /product="decaprenylphospho-beta-D-erythro-pentofuranosid- 2-ulose 2-reductase" /protein_id="WP_007731800.1" /transl_table=11 /translation="MINAVGNPQTVLLLGGTSEIGLAICEEYLKKAPLRVVLAALPGDP GREAAVKQLEAKGATSVELIDFDAVDFESHPKVIDQAFSNGDVDVAIVAFALDGDSEEL WQNQRKAVLVANVNYTASVSVGVLLGEKMKAQGFGKIIAMSSVAGERVKRANFVYGSTK AGLDGFYLGLGEALAEFGPQVTVVRPGMVRTQFSAHVKEAPLTVNKDIVAKLAVAASDK GKEIVWTPGPWRFVMMGLRHVPRPIFRKLPV" gene 2601..4454 /locus_tag="PXH69_RS11920" /old_locus_tag="PXH69_11915" CDS 2601..4454 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943916.1" /locus_tag="PXH69_RS11920" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11915" /product="galactan 5-O-arabinofuranosyltransferase" /protein_id="WP_064688150.1" /transl_table=11 /translation="MALGALVAAVVAAVGLFAFGRVQWPAFTSSNVTQAVTTVLQVLCI AVVGVAVLMFRARKAERVAKLLSWAGLSGFVTTTLGLPLAATSLYLHGVSVDQQFRTEY LTRLTDSAALQDMTYVDLPPFYPAGWFWIGGRVANLLGMDGWEAFKPYAIGSLAVVAVV ALVLWTKLIRRDWAVVAALAVTAVVLAYNSPEAYGAVINLLIPPVLILAWGALDRPGAS RFAGAGAILGTGLFLGFAATVYTLYLAFAAFSVTLMAVVAAVMAAKAKNTWKAALNPLI RLVVIAAIAGVVALTVWTPYLLKALSGATSESGTAFHYLPDSGAVLPFPMLSFTLVGGL CLLGTIWLISRFLFSRRARALGIGVIAVYLWALLSMTFTVAGSTLLGFRLEPVLIGLLA AAGVFGFFEFAGWIVLATSENPRVKAVLVALGVIGAIAFAQNIPQVLAPDIAVAYSDTD GNGERGDKRPPGAEANYADIDRIIREQLGREPHDTVVLTADIGFLSFYPYFGFQGLTSH YANPLADFRARAALIEQWSELKTPDELVAALDSAPWRSPDAFVFRQGADGYTLRLAEDV YPNDPNVRRYTVTFPKELFDDPRFTVTEQGPFVVVTRSDAI" gene 4528..5136 /locus_tag="PXH69_RS11925" /old_locus_tag="PXH69_11920" CDS 4528..5136 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746422.1" /locus_tag="PXH69_RS11925" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11920" /product="TetR/AcrR family transcriptional regulator" /protein_id="WP_003943927.1" /transl_table=11 /translation="MPRTDARAAMIDAAERLVAERGLAALTLRDVQTEAGQANKSAAQY HFGSREGLLAAVVESRMRPAGERRRELLDTIDLDANPPTMRALVEALVLPLAEQTIYRE GTLYARFLVQSIFDPAMSSTIRDHMQAESFREVQRRIVAASSLPAEIAELRAGTLTVLT VVTFATWEGRVDSRERAHVIVADLIESCLGALSAPAAQI" gene 5236..5868 /locus_tag="PXH69_RS11930" /old_locus_tag="PXH69_11925" CDS 5236..5868 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746421.1" /locus_tag="PXH69_RS11930" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11925" /product="hypothetical protein" /protein_id="WP_202022615.1" /transl_table=11 /translation="MTVSELVAQSRELVPHRAVLDSAEHVLVIARGKPFGREQAFHEVL SVAIRNRIEVLTLARALIDVSESRDYRAIPTDTAHTVAVLEWGELLEIPTEHHEKSRAE SSEDVDESSEPDDPIEPEYLVETDVGGRVVFVALAFTIGGIVGFFAHDWALLLLITAVY LVWIAARLVAKLVSVSRSAHWADASPIRGADSTTRNAENSHHHAVAA" gene complement(5890..6579) /locus_tag="PXH69_RS11935" /old_locus_tag="PXH69_11930" CDS complement(5890..6579) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746420.1" /locus_tag="PXH69_RS11935" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11930" /product="MspA family porin" /protein_id="WP_037126068.1" /transl_table=11 /translation="MGWCLCMSKTAVRSSAVGAVALLAVVLGGGTASAGVDNTSSITDV KGNRIEVFQADTAIHVFPPLDSSPLSVEFFHDGVAGVKIDGPDAASFTGTKLTIGYQIG YPIALTGATVVLNSPGLDWAVESGTNLGIGLVPDFELGLDISNGFVIGGDIIPSQELDV DLAPGGITDVALLEDQEFDGPEAAVRLSGVHGYVQGAIGPVTIRPYAKAVTSNGDTVVT YGVPQRL" misc_feature complement(6734..6748) /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 18.76" /tool="antismash" gene 6896..8728 /locus_tag="PXH69_RS11940" /old_locus_tag="PXH69_11935" CDS 6896..8728 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731806.1" /locus_tag="PXH69_RS11940" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11935" /product="hypothetical protein" /protein_id="WP_003943849.1" /transl_table=11 /translation="MTETLPDVQLLEEARPGRVRSAVRRSVVQRGRLVDLAIMATFTVA AIYVMSNLWSDLQSGYLFNAGRDQAMWEWFFADTAHALAQFRSPLFSDLQNYPLGVNLM ANTAMFGISIPLAPITLIFGPTATYAIGLTAGLGGTAIAWYWAFSRHVLTGVSVRSKIA AAVGAGFCGFAPAMISHANGHPNFVAFFVLPFIFLQVVRISNGKRPVRDGVVLGLLVAW QIFLGEEPLLIFTMSAMVFGAAYALPGLAKSRQAIKRAMPGLVIGGAVTLLITAVPLWS QFFGPASYDGVSHGQAGNDTAALTTFPTESVAGDPEGAEFRMNPTEENAYFGWPLVLLL LGATVWLWRIRLTRAAAAVIVVMGVLSLGSELTIDGDKTGITLPWKLLADLPLFESVLE SRFAMGAIPAIGLLLTLGTYRAFVELRGPRRTAAGVWLVALAVAMIPLIPTPIDADQRS ATPEFITSGSWENYVSDGTLVTVPVASAEDARALSWQVDADFGFPIAGGYFVGPDSKTR AGIYGAESRPTSTLLVNAKQTGKVPLIDVGTRANALTDLRYWHADVLVLPRFSGDDALR HTVDELVGFDAKRVDDVWVWDVRDLVSGKTSNQS" gene complement(8738..9502) /gene="map" /locus_tag="PXH69_RS11945" /old_locus_tag="PXH69_11940" CDS complement(8738..9502) /EC_number="3.4.11.18" /GO_process="GO:0036211 - protein modification process [Evidence IEA]" /codon_start=1 /gene="map" /gene_functions="biosynthetic-additional (smcogs) SMCOG1172: methionine aminopeptidase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005253208.1" /locus_tag="PXH69_RS11945" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11940" /product="type I methionyl aminopeptidase" /protein_id="WP_020905776.1" /transl_table=11 /translation="MVEIKTAGEIDAMAAAGRITAQALAAAREAASVGVTLLELDAVAA EVISAAGASALFLNYRPATAPIPFPGVACISVNDAVVHGIPNGYRLRDGDLVSIDCGAR LDGWCGDSAISFTVGQGSSEDQALIDATDEALARGIAAAQPGNRLGDIGAAIGQYARGL GYGMLADHGGHGIGREMHEGPDVPNEGRAGKGFRLRPGLVIAIEPMLIADGTDDYRHDA DGWTLRTVSGARAAHSEHTVAITEDGPVIMTR" gene 9552..9821 /locus_tag="PXH69_RS11950" /old_locus_tag="PXH69_11945" CDS 9552..9821 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943854.1" /locus_tag="PXH69_RS11950" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11945" /product="helix-turn-helix transcriptional regulator" /protein_id="WP_003943854.1" /transl_table=11 /translation="MVRVPLTAEELERGLRLGELLRSARGDRSMVQVALDAGISVETLR KIETGRIATPAFFTISAVAEVLGISLDTIARTLETPQSEQEVAS" gene 9889..13158 /locus_tag="PXH69_RS11955" /old_locus_tag="PXH69_11950" CDS 9889..13158 /GO_function="GO:0052636 - arabinosyltransferase activity [Evidence IEA]" /GO_process="GO:0071766 - Actinobacterium-type cell wall biogenesis [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1236: integral membrane indolylacetylinositol" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943802.1" /locus_tag="PXH69_RS11955" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11950" /product="arabinosyltransferase domain-containing protein" /protein_id="WP_100245448.1" /transl_table=11 /translation="MPPKPVPTGPEAPRESDSQRVRTARLIAIVTGLLGLLLALATPFL PVKQEAASIDWPQGGTVNSVSSPLISYSPTSLDISIPCSTLGQLGGSGGTLLSTMPNGA PDRNARGLTVRTTADRLEALTRDSVLISTPLDQLSGCTAITITTNSEQTVAAVTGIDGV GTTLTGDYRPQVVGIFTDLQGAAPAGLSAHMDVDSRFSSSPTLLKLFAMIVAALSTIVS LYALHRIDGVDGRRARRFLPARWWKFTGIDALVIGTLALWHVFGANTSDDGYLLGMARV SEHSGYMANYFRWFGVPEAPFGWYYDVLALFAKVSTASMWMRLPALIAGILCWMVISRE VIPRLGVAVRRNKVAIWTGGLVFLAFWLPYNNGLRPEPIIALGALLTWCSIERAIATGR LLPAAMAVLIAAFSLAAGPSGLIAIGALIAGARPILQILIARGKRVGFLSQIMPILAAG TVVLVAVFADQTLATVLESTRVRTAVGPNVPWFEERLRWDALMTISPDGSLARRFGMFV MIVGLVFCVMMILRKGRIPGTAIGPSRRILGIVFASLLLMQFTPTKWTHHFGVYAGLAA TVAVLAAVGVSASSMRSKRNRALFAAGILFILAVAFTSSNGWWYVSSYGVPWWDKPPSI AGKGFSTAFLGLTILALLLAAWYHVMEPRRRNGTEDSVKKTRRLRLLAPSPLTIAAGAV VLFEVLSLLKGAVAQYPAYSIGKSNIESVFGGSCGLAGEVLVESDPNAGVLQLTDRPTD LAGAGAFGASESTGFSPDGVAGDLTADAEDSTAGSANSLDTSTSQSGTTTPGTGSGTAG GSQSTAGVNGSNVALPFGLDPAKTPVLGSYGAPQNASLTTGWYSLPERNDAAPLLTVAA AGRIRYVNSDGIVTPGAVLQVEYGKKQADGSVDALGRVDPIDIGPSPSWRNLRVPMDQL PADADTVRLVASDTDISADQWLAVTPPRVPTMRTLQDVVGSTDPVLMDWAVGLAFPCQR PVDHLYGVAEIPDWRILPDRIGAESTNAWQDHYGGGPLGWTTELLSARALPTYLDNDWD RDWGSLEQYTPLDSDAVPAQMNVTTETRSGTWTPGPIRYQS" gene 13232..16534 /locus_tag="PXH69_RS11960" /old_locus_tag="PXH69_11955" CDS 13232..16534 /GO_function="GO:0052636 - arabinosyltransferase activity [Evidence IEA]" /GO_process="GO:0071766 - Actinobacterium-type cell wall biogenesis [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1236: integral membrane indolylacetylinositol" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746416.1" /locus_tag="PXH69_RS11960" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11955" /product="arabinosyltransferase domain-containing protein" /protein_id="WP_030535817.1" /transl_table=11 /translation="MPDAVTASPQTSSSPPPAGQDARERFHRTRWVAIIAGLLGFVLAL ATPLLPVVQTTASVNWPQNGVIGDVEAPLMAQVPIDVNASIPCTAVSSLPEGGGILLST APAQGDGAALSSMFVRVSATSVDVLDRNVVVASAAREDVESSRCGAIAFSSDVNRTTAE FVGLTYPDGNPIRGQLDGDFRPQVVGVFSDLPDGAAPEGLGFSMTIDSRFSSSPSVLKL VAMIVAVLSTIVALVALARLDGTDGRKHRRFLPARWWKFSGIDGVVVGTLVVWHFIGAN TADDGYLLTMARVSPDAGYMANYFRWFGVPEAPFGWYYEVLAVMAKISTASPFMRLPAL LAGILCWMVISREVVPRLGRAVRRSNVALWTGGLVFLSFWLAYNNGLRPEPIVALGALL TWCSIERAIATGRLLPAATAILIGAFTLAAAPTGLMCIAALLAGVRPLVRIVVKRHRLV GTLPLLAPIAAAGTIVLVVIFADQTFAGVMEATRVRTIIGPNLEWYQDFLRYYYLFVQT VDGSVARRFAFLTMILCLFTTLFVLLRRGRVPGAATGPSWRLVGVVFGTMFLMMFNPTK WTHHFGAYAGIAGSLAALTAVAVSASALRSRRNRSVFVAGLLLMLALTFAGINGYWYVS SYGVPWFDKTISYDGRESNTLFLALFALALAFAAWQYLREGFAAPPEKPNTAKGRRIRK FAAAPLTVIAGLMVLFEVLSLLKGAVSQYPAYSLGRSNIEALAGKTCGMAEDVLVETDV NSGNLRPLTAPGFNAEDPLSGVDSKGFSPNGVPSDLTADYIEVKQGMGNTDSQSVGPTF ATGSGAGTSGGTGNVGVNGSTAKLPFGLDPSKTPVMGSYQPGVQEPASLISSWYGLPTR SEESPLVVMSVAGRVWSVDNTGAITYGQSLLVEYGKTQPDGTVQVQGSYMPRDIGPAPS WRNVRIPIDELAPDADAVRVVAFDPNLTGDQWMAFTPPRVPKLESLNSYIGNEQPVLLD WAVGLQFPCQRPFTHQNGVAEMPNFRILPDRPLAVSSTDTWQSADNGGPLGFTEVLAGA TTVPTYLKDDWARDWGSLERYDRYFPNAVPAEVETGTATRSGMWMPGEMRVH" misc_feature complement(13244..13256) /note="TFBS match to MatP, Cell cycle regulator, confidence: weak, score: 22.57" /tool="antismash" gene complement(16531..17481) /locus_tag="PXH69_RS11965" /old_locus_tag="PXH69_11960" CDS complement(16531..17481) /GO_function="GO:0005215 - transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1166: transporter, EamA family" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731812.1" /locus_tag="PXH69_RS11965" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11960" /product="DMT family transporter" /protein_id="WP_192712866.1" /transl_table=11 /translation="MTTLTSATAQTSTPTRTPRGRIDPRLLVVGGAAAISISSLLIKLA DVGPSTAVFFRCFLALPPLLWLAWREYRRVGKPSRRAVVLQVLGGLLLGLDFALWSQSI LMIGAGMASVVVNVQVVVVPALSWLVFGHRVPMRFVFALPFMFTGIALAGGVFGGGGTG DDLMWGTALSLVSGIAYGGYIFVVGRTGEADRAASQVLISTTSAGIAGSVIGSLWGRID FVPGWEAFGWLAALALVGQVFGWMLMGNSLPRLPAEVGATLLLMQPVLAVLLAVVLLGE RPGVGQLLGCVVVVGAVSAVSVRRTRAVTRVGSAG" misc_feature complement(17527..17540) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: weak, score: 18.36" /tool="antismash" misc_feature 17539..17555 /note="TFBS match to HexR, Glucose-responsive regulator, confidence: weak, score: 18.5" /tool="antismash" gene 17555..18466 /locus_tag="PXH69_RS11970" /old_locus_tag="PXH69_11965" CDS 17555..18466 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1014: LysR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731813.1" /locus_tag="PXH69_RS11970" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11965" /product="LysR family transcriptional regulator" /protein_id="WP_065351773.1" /transl_table=11 /translation="MLNLERLRALHAVAENGSVAAAARTLHVTPSGISQQLNKLEREVG VPLLEPQGRGVRLTEAGRILARRTAEVLSTLAQAEAEIASLQSEVTGRVRIGALVSPSR TVLPRAIAEIRHAHPQLEITFNEGESEELLPALIRRDLDVVVVDSWSTLPVELPDGLSF TPVYDDVALLALPTSHPLAENKVVALSELSEHAWATWTRGTDFHTFTVRTLRAQGFDPR IEYEVAEFPTQVEFVAQGLAVALIPRLARVVPPEGVRMLDTVPPLGRDIYLAWRTDSER PAVLAAIEALRRQFDALGDKKN" gene complement(18463..20004) /locus_tag="PXH69_RS11975" /old_locus_tag="PXH69_11970" CDS complement(18463..20004) /EC_number="6.-.-.-" /GO_function="GO:0016874 - ligase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase," /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012691128.1" /locus_tag="PXH69_RS11975" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11970" /product="acyl-CoA carboxylase subunit beta" /protein_id="WP_003943957.1" /transl_table=11 /translation="MTTTTAEKLAELREKLEKAKEPGSARAIAKRDAAGHSTPRQRIDM LLDPGSFIEIGALVKMAGEGNPYSDGVMTGHGTVDGRPVAVFAHDQTVFGGAAGEMFGR KVAAVNDFALKVGCPVVGINDSGGARIQDAVSSLAWYANMGSRQEPLSGLCPQISVILG KCAGGAVYAPINTDVVVATEESYMFVTGPDVIKSVTGEEVSLEDLGGARKQAEYGNIHH VAPDEKAAFDWVREYLSFMPSSCQEKAPLINPGLEPEITESDLELNAFMPDADNAGYDM HDIILRIFDDGTFHEIGAQVAHNVITGFSRVDGLPVGVVANQPTYLSGALDADSSDKAA HFVRLCDAFNIPLVFVVDTPGFLPGVDQEKVGVIKRGGRFLFSYIEATVPKVTVVVRKA YGGGYAVMGCKQLGADINLAWPTARIAVMGAEGAVNIMGRRQLAEAGENAPAVRAQLIN FYNEFVATPYIAAERGYIDAVIEPSQTRLEIRKALKLLADKTIFKNPRKHNLMPL" gene complement(20001..24950) /gene="pks13" /locus_tag="PXH69_RS11980" /old_locus_tag="PXH69_11975" CDS complement(20001..24950) /GO_process="GO:0071768 - mycolic acid biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: ACP (22-91). E-value: 1.6e-17. Score: 55.6. Matches aSDomain: nrpspksdomains_PXH69_RS11980_ACP.1" /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (116-539). E-value: 3.4e-171. Score: 561.7. Matches aSDomain: nrpspksdomains_PXH69_RS11980_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (656-959). E-value: 3.2e-72. Score: 235.3. Matches aSDomain: nrpspksdomains_PXH69_RS11980_PKS_AT.1" /NRPS_PKS="Domain: PKS_PP (1148-1217). E-value: 4.6e-10. Score: 31.7. Matches aSDomain: nrpspksdomains_PXH69_RS11980_PKS_PP.1" /NRPS_PKS="Domain: Thioesterase (1382-1617). E-value: 1.3e-22. Score: 73.3. Matches aSDomain: nrpspksdomains_PXH69_RS11980_Thioesterase.1" /codon_start=1 /gene="pks13" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) Thioesterase" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731814.1" /locus_tag="PXH69_RS11980" /note="Pks13 is a key enzyme in mycolic acid biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11975" /product="polyketide synthase Pks13" /protein_id="WP_192712865.1" /sec_met_domain="PP-binding (E-value: 2.9e-10, bitscore: 34.8, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="ketoacyl-synt (E-value: 7e-82, bitscore: 268.9, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="PKS_KS (E-value: 1.7e-170, bitscore: 561.7, seeds: 2284, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 1.6e-71, bitscore: 235.3, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="Thioesterase (E-value: 8.8e-20, bitscore: 66.0, seeds: 16, tool: rule-based-clusters)" /transl_table=11 /translation="MVEQDGAQSKDVVSEMSVAQLREWLRNWIANATGQPAGSITDDRP MEEFGLASRDAVALSGDIEDLLGVTLTATVAYQHPTIASLATRIIEGEPEAPEETVDAS YYVSGGATDAHDIAIVGLSTRFPGAGHTPSDMWEMLADGRDGISDLPEDRWAEFMSDPA IKAAVENANTKGGYLDDVKGFDAEFFAMSPLEVVNVDPQQRLALELAWEALEHARIPAS GLKGKQVGVFIGSSANDYQLLAVSDPTTAHPYALTGTSTAIVANRVSYFFDFRGPSIAL DTACSSSLVAVHEAVRSLRSGDSNIALAGGVNMLLAPPGTLGFDQTGMLAPDGKLRAFS AQAQGIVRSEGGGLVVLKRLEDAERDGDSILAVIAGSAVNQDGRSNGLLAPNPDAQADV LRFAYRDAGILPTTVDYIEAHGTGTDLGDPIEADALSRVVGRGRDDDKPALLGSAKTNF GHLEAAAGAAGLIKVVLAMQENKIPATINYLGPNPHIDFEKSHLQVTPEATDWPRYTGK AVAGVSGFGFGGTNAHVVVKEYVPAETVVDEPVVDAPVVDEPAAENESTVVLAVSGALP SRRRRAAADLADWLETEEGSKTPLADVARTLARRNHGRSRAAVLAKTRSEAISSLRAVA AGKPAQGVFSADSPSPKGAVWVFSGFGSQHRKMAKQLYTENSAFKAAVDEVDALIQDEA GYSMVEMFLDDSIEYNVETAQVGIFTIQVGLAALLRHHGAEAEAVVPHSMGEAAAAYVS GGLNLEDAVRVICSRSRLMGEAEGALVGDDIRLMALLEYSASEIEALLPTYPKLEVCVY AAPTHTVIGGPQPDIEAIVAAAEADGKMARVLQTKGASHTSQVDPLLGELAAELAGIEP TTLKLGVYSSVDKDTFYRPGHEPIHQEAYWVKGLRHSVYFTNAVRGAVAHGHTTFVELA PNPVTLMSVAATAFDSGLHDMELIQTLKRKEDESAGVLAALAQLYVHGHAVNLESLLPA GDFASVPRTAFLRKPYWLDIRVSAGGSARVPGSHVALPDGRHVWEVDASAVTDLAVLVS AAAGQVLSDVALTAAVPRGELAGAATLTTTLNPHPGGASVQVHAREGATFRLLFDAVVT SGEPLPELVVSAPVKTSAPMESLAEVVEDAGDKWDPNGSQSLDDRLKIVVAESMGYSPE DLPAEVPLIELGLDSLMAMRIKNRVEYEFDIPQLQLQAVKDASLNEVNKYLRYAIDNRE EVQAMADKQAAEKLAADAADEDAAPAEVAVELPATAPVAAAAAPADPSRAGTADDAGSD VPPRDAAERLTFATWAVVTGKSAKGIFNDLPIVGDEVAEKLAARLSERAGGEITLDDVL DSTTIEELADVVRQYLEDDGKIDGLVRTLRARPEGSTAVPVFVFHAAGGSTVTYEPLLK RLPAGTPMYGFERVEGSIETRAAAYVPLLREIQGDGPYVLCGWSFGGVMSYAVAKLLRE QGADVRVVGLLDTVMAGEVVPDTEAERRKRWERYGKFAKRTYNLDVPLPLDVLASTEAD EDQIQILMDMIKMSGAKIPGGIIEHQRTSWLDNRAIQTAEFSSYDGDVVLYMADKYHDE LMTLEPAFKTRKADGGWGDYVKNLEVVYIGGDHLQIVDEPYIAKVAADLTTKLAQIETA QTKAAETGVQK" aSDomain complement(20100..20804) /ASF="active site serine inconclusive" /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11980_Thioesterase.1" /evalue="1.30E-22" /label="PXH69_RS11980_Thioesterase.1" /locus_tag="PXH69_RS11980" /protein_end="1617" /protein_start="1382" /score="73.3" /tool="antismash" /translation="PVFVFHAAGGSTVTYEPLLKRLPAGTPMYGFERVEGSIETRAAAY VPLLREIQGDGPYVLCGWSFGGVMSYAVAKLLREQGADVRVVGLLDTVMAGEVVPDTEA ERRKRWERYGKFAKRTYNLDVPLPLDVLASTEADEDQIQILMDMIKMSGAKIPGGIIEH QRTSWLDNRAIQTAEFSSYDGDVVLYMADKYHDELMTLEPAFKTRKADGGWGDYVKNLE VVYIGGDHLQIVD" aSModule complement(20100..24602) /complete /domains="nrpspksdomains_PXH69_RS11980_PKS_KS.1" /domains="nrpspksdomains_PXH69_RS11980_PKS_AT.1" /domains="nrpspksdomains_PXH69_RS11980_PKS_PP.1" /domains="nrpspksdomains_PXH69_RS11980_Thioesterase.1" /final_module /locus_tags="PXH69_RS11980" /monomer_pairings="pk -> pk" /tool="antismash" /type="pks" CDS_motif complement(20574..20648) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0007" /evalue="4.10E-11" /label="NRPS-te1" /locus_tag="PXH69_RS11980" /protein_end="1459" /protein_start="1434" /score="35.2" /tool="antismash" /translation="QGDGPYVLCGWSFGGVMSYAVAKLL" aSDomain complement(21300..21506) /aSDomain="PKS_PP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11980_PKS_PP.1" /evalue="4.60E-10" /label="PXH69_RS11980_PKS_PP.1" /locus_tag="PXH69_RS11980" /protein_end="1217" /protein_start="1148" /score="31.7" /tool="antismash" /translation="LDDRLKIVVAESMGYSPEDLPAEVPLIELGLDSLMAMRIKNRVEY EFDIPQLQLQAVKDASLNEVNKYL" aSDomain complement(22074..22982) /ASF="(Methyl)Malonyl-CoA specificity inconclusive" /ASF="found active site serine: True, scaffold matched GHGE: False" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11980_PKS_AT.1" /evalue="3.20E-72" /label="PXH69_RS11980_PKS_AT.1" /locus_tag="PXH69_RS11980" /protein_end="959" /protein_start="656" /score="235.3" /specificity="substrate consensus: pk" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: fatty_acid" /tool="antismash" /translation="VFSGFGSQHRKMAKQLYTENSAFKAAVDEVDALIQDEAGYSMVEM FLDDSIEYNVETAQVGIFTIQVGLAALLRHHGAEAEAVVPHSMGEAAAAYVSGGLNLED AVRVICSRSRLMGEAEGALVGDDIRLMALLEYSASEIEALLPTYPKLEVCVYAAPTHTV IGGPQPDIEAIVAAAEADGKMARVLQTKGASHTSQVDPLLGELAAELAGIEPTTLKLGV YSSVDKDTFYRPGHEPIHQEAYWVKGLRHSVYFTNAVRGAVAHGHTTFVELAPNPVTLM SVAATAFDSGLHDMELIQTLKR" CDS_motif complement(22644..22754) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0006" /evalue="3.90E-14" /label="PKSI-AT-mM_m3" /locus_tag="PXH69_RS11980" /protein_end="769" /protein_start="732" /score="44.7" /tool="antismash" /translation="GAEAEAVVPHSMGEAAAAYVSGGLNLEDAVRVICSRS" CDS_motif complement(22932..22988) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0005" /evalue="1.90E-03" /label="PKSI-AT-mM_m1" /locus_tag="PXH69_RS11980" /protein_end="673" /protein_start="654" /score="11.1" /tool="antismash" /translation="VWVFSGFGSQHRKMAKQLY" aSDomain complement(23334..24602) /ASF="found active site cysteine: True, scaffold matched GSSS: True" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11980_PKS_KS.1" /domain_subtypes="Hybrid-KS" /evalue="3.40E-171" /label="PXH69_RS11980_PKS_KS.1" /locus_tag="PXH69_RS11980" /protein_end="539" /protein_start="116" /score="561.7" /tool="antismash" /translation="IAIVGLSTRFPGAGHTPSDMWEMLADGRDGISDLPEDRWAEFMSD PAIKAAVENANTKGGYLDDVKGFDAEFFAMSPLEVVNVDPQQRLALELAWEALEHARIP ASGLKGKQVGVFIGSSANDYQLLAVSDPTTAHPYALTGTSTAIVANRVSYFFDFRGPSI ALDTACSSSLVAVHEAVRSLRSGDSNIALAGGVNMLLAPPGTLGFDQTGMLAPDGKLRA FSAQAQGIVRSEGGGLVVLKRLEDAERDGDSILAVIAGSAVNQDGRSNGLLAPNPDAQA DVLRFAYRDAGILPTTVDYIEAHGTGTDLGDPIEADALSRVVGRGRDDDKPALLGSAKT NFGHLEAAAGAAGLIKVVLAMQENKIPATINYLGPNPHIDFEKSHLQVTPEATDWPRYT GKAVAGVSGFGFGGTNAHVVVKEY" CDS_motif complement(23553..23597) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0004" /evalue="4.50E-03" /label="PKSI-KS_m6" /locus_tag="PXH69_RS11980" /protein_end="466" /protein_start="451" /score="9.8" /tool="antismash" /translation="GSAKTNFGHLEAAAG" CDS_motif complement(23658..23705) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0003" /evalue="1.80E-04" /label="PKSI-KS_m5" /locus_tag="PXH69_RS11980" /protein_end="431" /protein_start="415" /score="13.5" /tool="antismash" /translation="YIEAHGTGTDLGDPIE" CDS_motif complement(24078..24125) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0002" /evalue="3.40E-06" /label="PKSI-KS_m3" /locus_tag="PXH69_RS11980" /protein_end="291" /protein_start="275" /score="19.0" /tool="antismash" /translation="GPSIALDTACSSSLVA" CDS_motif complement(24543..24575) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11980_0001" /evalue="8.20E+01" /label="PKSI-AT-mM_m1" /locus_tag="PXH69_RS11980" /protein_end="136" /protein_start="125" /score="-2.9" /tool="antismash" /translation="FPGAGHTPSDM" aSDomain complement(24678..24884) /ASF="found active site serine: True" /ASF="non-beta-branching ACP" /aSDomain="ACP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11980_ACP.1" /evalue="1.60E-17" /label="PXH69_RS11980_ACP.1" /locus_tag="PXH69_RS11980" /protein_end="91" /protein_start="22" /score="55.6" /tool="antismash" /translation="EWLRNWIANATGQPAGSITDDRPMEEFGLASRDAVALSGDIEDLL GVTLTATVAYQHPTIASLATRIIE" gene complement(24988..>25185) /locus_tag="PXH69_RS11985" /old_locus_tag="PXH69_11980" /pseudo="" CDS complement(24988..>25185) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010596187.1" /locus_tag="PXH69_RS11985" /note="activates fatty acids by binding to coenzyme A; incomplete; too short partial abutting assembly gap; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11980" /product="fatty-acid--CoA ligase" /pseudo="" /transl_table=11 /translation="QPIADTVRAAISSRHGVTARDILLVPAGSIPRTSSGKIARRACKA SYIEGTLRGGYQQTAFPDSV" ORIGIN 1 acgattgatg aggtacgccg tcgtggtgcc cgcaacgaag ctcagcgatt ttgcggcgac 61 gcgcggcaac cccaacgcga ggagcagcac atacagcccg tagtccacga ccgccgacag 121 cccacccgtc gcgacgaacc ggacgatctg cgttttcagg tccaacgcgt cgtcggcgat 181 gtccgtcgtg acaggaatct cgacgggcag cgggacgtgg ggttcgtgct ggtgacttgc 241 aggtgtttcg ggcacgacga cgagagtaac cactcgagtc ggagccgtcg gcactactcc 301 caggtaacct ctaccttgat gtccacgaca gcagaagaga cgccgcagcc ggctctccac 361 acccaagccc gcaccctcac cggttgggga cgcaccgccg ccaccactgc acaggtgctg 421 tccacccccg acgtggaagt gatcgccaac gcggtcgccc aggttgcgga acagaacgat 481 tccaagccct cgcatctgcg acgcggcgtc atcgcgcgcg gcctcggccg ctcgtacggt 541 gacccagcgc agaacgccgg cggcctggtc atcgacatga atgcactcag ccgcattcac 601 cgcatcgatc gcgacaccgc tctggtggac gtcgacgccg gcgtgaatct ggatcagctg 661 atgaaggctg ctctgccgtt cggcctgtgg gttccggtcc tgccgggtac tcgtcaggtc 721 acgatcggcg gcgccatcgg ctcggatatc cacggcaaga accaccatag cgcgggcagc 781 ttcggcaacc acgtcgtgtc gttggatctg ctgacggccg acggcaaggt tcgcacgctc 841 acccccaagg gcgggcgcaa cgacccgaag gccgcactgt tctgggccac gatcggcggc 901 atgggcctga cgggcatcat cttgcgggca accatcaaga tgacaccgac ggagacggcg 961 tacttcatcg ccgacggcga cgtcaccaac agcctcgacg agaccatcgc gctgcacagc 1021 gacggcagtg aggccaacta cgagtattcg agcgcgtggt tcgacgcgat ttccgcgccc 1081 ccgaagctcg gccgggcggc agtctcgcgc gggtcattgg cgaagctcga ccagcttccg 1141 gccaagctgc agaagaaccc gctcgccttc gacgcaccgc agttgctgac gttccccgac 1201 gtcttcccga acgggctggc caacaagttc aacttcaccg cgatcggtga ggtctggttc 1261 cgcaagtccg gcaagtatcg cggcaaggtc cagaatctga cgcagttcta ccacccgctc 1321 gacatgttcg gtgagtggaa ccgcgcgtac ggatccaacg gattcctgca gtaccagttc 1381 gtggttccgc cggaggccgt cgacgagttc aagaagatca tcgtcgacat ccagcgcagc 1441 gggcactact cgttcctcaa cgtgttcaag ctcttcggcg aaggcaatca ggcgccgctg 1501 agcttcccga tcccgggctg gaacatctgc gtcgacttcc gcatcaagcc gggcctgaac 1561 gagttcgtca ccgaactcga caagcgtgtc ctcgaattcg gcggacgcct gtacacggcc 1621 aaggactcgc ggacgtccgc ggaaaccttc cacgccatgt acccgcgcat cgacgagtgg 1681 atcgcgacgc gccgcaagta cgaccccaca ggcgttttcg cctccgatat gtccagaagg 1741 ctggaactgt gatcaacgct gtaggtaacc cgcaaaccgt tttgcttctc ggtggaacct 1801 ccgagatcgg cctcgccatc tgtgaggaat accttaagaa ggcgccgctc cgcgtcgttc 1861 tggcggcact ccctggcgat ccgggacgcg aagctgcggt caagcagctc gaagcgaagg 1921 gtgccacctc ggtggagctc atcgacttcg acgccgttga tttcgaatcg cacccgaagg 1981 tgatcgacca ggcgttctcg aacggtgacg tcgacgtcgc gatcgtcgcc ttcgcactgg 2041 acggtgactc cgaagagctg tggcagaacc agcgcaaggc cgttctggtg gcaaacgtca 2101 actacaccgc ttccgtctcg gtcggcgttc ttctcggcga gaagatgaag gctcagggct 2161 tcggcaagat catcgcgatg tcgtcggttg ccggcgagcg cgtcaagcgt gccaacttcg 2221 tctacggctc caccaaggcg ggcctcgacg gtttctacct cggactcggc gaggctctcg 2281 cggaattcgg accgcaggtc accgtcgttc gccccggcat ggtgcgcacg cagttcagtg 2341 cccacgtcaa ggaagctccg ctgacggtca acaaggacat cgtcgcgaag ctcgctgttg 2401 ccgcctcgga caagggcaag gaaatcgtct ggactcccgg cccgtggcgc ttcgtcatga 2461 tgggtcttcg ccacgtgccg cgcccgatct tccggaagtt gccggtttaa gctcctcccg 2521 tgccagaaac aacaactgct ccgagtacag acctttcgac cccgtcgccg tggcgtaatg 2581 ccgcggcgac ggtggtggaa atggccctcg gagcgctggt cgccgctgtt gtagccgctg 2641 tcgggctctt tgctttcggc cgagtgcagt ggccggcgtt cacctcttcc aatgtcacgc 2701 aggcagtcac gacggtgctg caggtgctct gcatcgcagt ggtcggtgtt gcggttctga 2761 tgttccgcgc ccgcaaggcc gagcgggtcg caaaactcct ctcgtgggcc gggctctccg 2821 gcttcgtcac cacgacgctc ggacttcccc tggccgcgac gagtctgtat ctgcacggcg 2881 tctcggtcga tcagcagttc cggaccgagt acctgacccg gctgacggat tctgctgcgc 2941 tgcaggacat gacgtacgtg gatctgccgc cgttctaccc ggccggctgg ttctggatcg 3001 gtggacgcgt cgcgaacctg ctgggaatgg acggctggga agccttcaag ccttatgcga 3061 tcggctcgtt ggctgtcgtc gccgtcgttg cactcgtgtt gtggaccaag ctgattcgac 3121 gcgattgggc cgtcgtcgcg gccttggccg tcactgccgt cgtgttggcg tacaactccc 3181 ccgaggcgta cggcgccgtc atcaacctcc tgatcccgcc ggtgctgatc ctcgcgtggg 3241 gtgcattgga ccggccgggg gcatctcgat ttgccggagc cggcgcaata ctcgggacgg 3301 gcctgttcct cggtttcgcc gcaacggtct acacgttgta cctcgccttt gccgccttct 3361 cagtcacttt gatggccgtc gtcgcagcag taatggcagc gaaggccaaa aacacgtgga 3421 aggcagcgct gaatccgctg atccgactgg tagtgatcgc cgcgatcgca ggggtagtgg 3481 ccctcacggt ctggactccg tacctgttga aagcactttc aggggcaact tccgaatccg 3541 gcacggcatt ccactatctt cccgattccg gtgcggtact gcccttcccg atgctgagct 3601 tcaccctcgt cggtgggctg tgcctactcg gcacgatctg gctgatttcg cggttcctgt 3661 tctcccgccg cgcccgagca ctcggtatcg gtgtcattgc cgtgtacctg tgggcactgc 3721 tgtccatgac gttcaccgtc gccggcagta cgctcctcgg tttccgactg gagccggtcc 3781 tgatcggact ccttgccgcc gccggtgtgt tcggtttctt cgagttcgcc ggttggatcg 3841 tgctggccac cagcgaaaat cctcgcgtca aagcggtact ggttgcactc ggtgtcatcg 3901 gagccatcgc cttcgcgcag aacatcccgc aggtgctggc gccggatatc gctgtggcat 3961 acagcgatac cgacggcaac ggcgagcgcg gggacaagcg acccccgggt gccgaagcca 4021 attacgccga catcgaccgg atcattcgcg agcagttggg acgcgaaccc catgacacgg 4081 tggtcctcac tgccgacatc ggcttcctga gcttctaccc gtacttcggc tttcaaggac 4141 tgacgtcgca ctacgcgaac ccgctcgccg atttccgtgc gcgcgctgcg ctgatcgagc 4201 agtggtcgga actgaagacg cctgacgaac tggtagctgc gctggactcg gcgccgtggc 4261 gcagccccga cgccttcgtc ttccgccagg gcgccgacgg gtacacgctg cggttggcag 4321 aggacgtcta ccccaacgac ccgaacgtcc gccgctacac ggtcacgttc cccaaggaac 4381 tgttcgacga tcctcgtttc accgtgaccg agcaggggcc gtttgtggtc gttacccgct 4441 ctgacgcaat ctaaccagga gatacgtcac aaaaggctta ccgtcggggt cgttgacgcg 4501 accccgacgc acccctaact tcataccgtg ccccgaaccg atgcccgagc ggcgatgatc 4561 gatgcagccg agcgtctggt tgccgagcga ggtctggccg ctctgactct tcgtgatgtt 4621 cagaccgaag ccgggcaggc caacaaatcg gctgcgcagt atcacttcgg gtcacgtgaa 4681 ggtttgctgg cggccgtcgt cgagtccaga atgcgacctg ccggtgagcg tcgtcgtgag 4741 ttgctcgaca cgatcgatct cgacgcgaat ccaccgacga tgcgtgccct cgtcgaggct 4801 ctcgtcctgc cgttggcgga acagaccatc taccgcgagg gcacgttgta cgcgcggttc 4861 ctggtgcagt cgatcttcga cccggcgatg tcgtcgacta tccgtgacca catgcaggcc 4921 gagagtttcc gcgaagttca gcggcggatc gttgctgcgt cctcgttacc ggcagagatc 4981 gccgaacttc gggcgggaac tctgaccgtg ctcaccgtcg tcacttttgc cacgtgggaa 5041 ggccgcgtcg acagccgcga acgtgctcac gtgatcgttg ccgacctgat cgaaagttgc 5101 ctcggagcac tctcggcccc ggctgcgcaa atctgacacg ctgtccggcg agtttgtttc 5161 cgaaaccgcc ggggtactca gcccctccaa gcgcagtcga gcaaacggcc gcatcaacca 5221 ccggcggggt aggtgatgac agtgagcgaa ctcgttgcgc aaagccgcga gcttgtaccg 5281 catcgtgcag ttctcgattc cgcagagcat gttctggtca ttgcgcgcgg caaaccgttc 5341 gggcgcgaac aggctttcca tgaagtgttg agcgtcgcga ttcgcaatcg catcgaagta 5401 ctcactctgg caagggctct catcgacgtg tccgagtccc gcgactaccg cgcgatcccg 5461 accgacaccg cgcacactgt tgcggtgctc gaatggggcg agctactcga gatccccacc 5521 gaacaccacg agaagtccag ggccgagtca tccgaggacg tcgatgaatc gagtgaaccc 5581 gacgatccga tcgaacccga gtatctggtc gagaccgacg tgggcggacg ggtcgtcttc 5641 gtcgccctcg cgttcacgat cggcgggata gtcggattct tcgcgcacga ctgggcactt 5701 ctgcttctga tcaccgccgt gtacctcgtg tggatcgcgg cacggttggt cgcgaaactc 5761 gtcagtgttt cccgtagtgc ccactgggca gacgcttcgc cgattcgtgg cgccgattcg 5821 accacacgga acgcggagaa ctcccaccat cacgctgttg cagcgtgacg gcgggagcat 5881 ccgctttcgc taaagcctct gcggtacacc gtaagtgacg acggtatcgc cattcgacgt 5941 gacagccttc gcgtacggcc tgatggtcac cggaccgatt gctccctgta cataaccgtg 6001 aactccggac agacggacag cggcttcggg accgtcgaac tcctgatctt cgagcagtgc 6061 gacgtcggtg ataccgcccg gcgccagatc gacgtcaagt tcctgcgaag gaatgatgtc 6121 accaccgatg acgaacccgt tcgatatgtc cagtcccagt tcgaagtccg gaaccaggcc 6181 gatcccgagg ttggttccac tctcgacagc ccagtcgaga ccaggactgt tgagaacgac 6241 cgtcgcgccg gttaacgcga tcgggtaacc gatctgataa ccgatcgtca gcttcgttcc 6301 ggtgaagctt gccgcgtccg gcccgtcgat cttcacgccg gcaaccccgt cgtggaagaa 6361 ctcgacactc agcggtgagc tgtcgagagg cggaaagaca tggatagcgg tatcagcctg 6421 gaagacttct atccgattcc ctttgacgtc ggtgatcgaa ctggtgttgt caacgcctgc 6481 cgacgccgtc ccacccccca ggacaacggc caacagggcc actgctccta ctgcgctact 6541 acgaactgct gtcttcgaca tgcacaagca ccatcccatc cggtataggc cccggacgta 6601 ggttccaact cttcgtcgag gatgggattc gtcggggctg cctgaacaaa tgcgagcaag 6661 atccttgttg cgataccccg gtcacgaacc cgtcaaacgg tgcacgaaaa cattactttc 6721 cggacaagtc gggcggaccg atttgtcccg ctgactgcgc ccgctcgcgg acgcgaaccg 6781 ttttgttcgt tactctgaca gtggaagtta tcgaatcgag acctaagtag gccaccccga 6841 acttctgaga tcgccacttc agggatgggc gccagaaccg aaaggcaccg actgcatgac 6901 cgagaccttg cccgacgtcc aactgctcga agaagcacgt ccagggcgag tccgttcagc 6961 agtgcggcgc tcggtcgtcc agcgcggtcg tctggtcgac ctcgcgatca tggcgacgtt 7021 caccgttgcg gcgatctacg tgatgtccaa cctgtggagc gatctgcagt ccggctatct 7081 gttcaacgcg ggccgcgacc aggccatgtg ggaatggttc ttcgccgata ccgctcacgc 7141 cctcgcccag ttccgcagcc cactgttcag tgacctgcag aattacccgc tcggcgtgaa 7201 cctgatggcc aataccgcca tgttcgggat cagcatcccg ctggccccga tcacgttgat 7261 cttcggaccg acagccacgt atgcgatcgg actgactgcc ggcctcggcg gcaccgctat 7321 cgcctggtac tgggcattct cgcggcacgt gctgaccggc gtctcggtcc gctccaagat 7381 cgccgccgcc gtcggagcgg ggttctgcgg atttgcgccc gccatgatct cgcatgccaa 7441 cggccacccg aacttcgtcg cgttcttcgt acttccgttc atattcttgc aggtagtgcg 7501 catttcgaac ggcaagcgtc cggttcgcga cggtgtcgtc ctcggcctac tcgtcgcctg 7561 gcagatcttc ctcggcgaag aaccgctcct catcttcacg atgtcagcca tggtgttcgg 7621 cgccgcctat gcactgcccg gcctggccaa gtcgcgccag gcgatcaagc gcgcgatgcc 7681 cggcctcgtg atcggcggcg cggtcacact cctgatcacc gcggtgccgc tgtggtcgca 7741 gttcttcggc ccagcgagct acgacggcgt ctcacacggt caggcaggca acgacaccgc 7801 tgcactcacc acgttcccga ccgaatcggt tgcgggcgac cccgagggcg cggagttccg 7861 aatgaacccg accgaggaga acgcgtactt cggatggccg ctggtgctcc tgcttctcgg 7921 tgcaacggtg tggctgtggc gcatccgcct gacccgcgcg gctgccgccg tgatcgtggt 7981 catgggtgtg ctctcactcg gttccgaact gaccatcgac ggtgacaaga ccggcatcac 8041 tctgccgtgg aaactcctcg ccgacctgcc gttgttcgaa tcggtgctcg aatcccgatt 8101 cgcgatgggc gcgattccgg cgatcgggct gctgctcacc ctcggcacct accgcgcttt 8161 tgtcgaactt cgtggaccgc gccgcacggc agccggtgtc tggctggtgg ctctcgccgt 8221 cgcgatgatt cccctgatcc cgacccccat cgacgccgat cagcgatctg cgacgcccga 8281 attcatcacc agcggctcgt gggagaacta cgtcagcgac ggcaccctgg tgacggttcc 8341 cgtcgcgagc gccgaagacg cccgcgcact gagctggcag gtcgacgccg acttcggctt 8401 ccccatcgcc ggcgggtact tcgtcggccc ggattcgaag acccgcgccg gaatctacgg 8461 cgccgagtcc cggcccacct cgaccctgct ggtcaatgcc aaacaaaccg gcaaggtccc 8521 gttgatcgac gtgggcacca gagcgaacgc actgaccgac ctgcggtact ggcacgccga 8581 cgtactggtg cttccccgat tctccggcga cgacgccctg cgccacacgg tcgacgaact 8641 ggtcggcttc gacgccaagc gcgtcgacga cgtgtgggtg tgggacgtac gagacctcgt 8701 gagcggcaag acctccaacc agagctgagc gggttgatca gcgggtcatg atcaccggac 8761 cgtcttcggt gatcgcgacc gtgtgctcac tgtgcgcagc ccgggcgccc gaaacggtgc 8821 gaagggtcca cccgtcggcg tcgtgccggt agtcgtcggt tccgtcggcg atgagcatcg 8881 gttcgatggc gatgaccagg ccgggccgta gccggaagcc tttgcctgct cggccttcgt 8941 tgggcacgtc cgggccttcg tgcatctcgc ggccgatgcc gtgcccaccg tgatcggcga 9001 gcattccgta tccgaggccg cgcgcgtact gtccgatcgc ggcaccgatg tcgcccaatc 9061 ggtttccggg ctgggcggcg gcaatgccac gggctagtgc ctcatcggtc gcgtcgatca 9121 gtgcctgatc ctcactactt ccctgtccga cggtgaagct gatggcggag tcgccgcacc 9181 agccgtcgag tctcgcaccg cagtcgatac tgaccaggtc accgtcacgg agtcggtacc 9241 cattcgggat accgtgcacc acagcatcgt tcacgctgat acaggccaca ccgggaaagg 9301 gtatcggcgc cgtcgccggc cgataattca agaacagcgc cgaggcgccg gcagccgaaa 9361 tgacctccgc ggcaacggcg tccaattcga gcaacgtcac tccgacgctc gccgcctcac 9421 gcgccgcagc cagcgcctgc gcggtgattc tccccgccgc cgccatcgcg tcgatttccc 9481 ctgcggtctt gatttcgacc atctcgaaca ccttccttgt cgaataacta taccggtatt 9541 actataagca catggtgcgc gtgccgctga cggcggaaga actcgaacga ggactacgac 9601 tgggtgaact cctgcgatcg gcgcgggggg accgaagcat ggttcaggta gcgctcgacg 9661 ccggcatctc ggtcgaaact ctgcgcaaga tcgaaaccgg ccgcatcgcg acacctgcct 9721 tcttcaccat cagcgcggtc gcggaagtgt tgggtatttc actcgacacc atcgcccgaa 9781 cacttgaaac accacaatcc gaacaggaag ttgcatcctg agtagttctc tcaggatgtg 9841 cgggcccgca ctcgcctaac atcgttcctt gtgccgtctg aagtagtagt gcccccgaaa 9901 cccgtgccca ctggccccga agctccccga gaatcggatt cccagcgagt ccggacggca 9961 cgactcatcg cgatagtcac cggccttctt ggcctgcttc ttgcactcgc gacgcccttc 10021 ctgcccgtca agcaggaagc cgcgagcatc gactggccgc agggtgggac cgtcaacagc 10081 gtctcgtcgc cgctgatctc ctactcgccc acatcgctcg acatcagcat cccctgttcc 10141 accctcggcc agttgggcgg cagcggcggc acactgctct cgaccatgcc gaacggtgcg 10201 ccggaccgaa acgcccgcgg cctcaccgtc cgcaccactg ccgaccgcct cgaagcactc 10261 acccgtgatt cggtgctgat ctcgaccccg ctcgatcaac tgagcgggtg cacggcgatc 10321 accatcacga ccaactccga gcagaccgtc gcggcggtca ccggaatcga cggcgtcggc 10381 accaccctga ccggtgacta ccgcccacag gtggtcggca tcttcaccga cctgcagggc 10441 gcagcgcccg ccggactgtc cgcccacatg gacgtcgact cccggttctc gtccagcccc 10501 acacttctca aactgttcgc gatgatcgtc gcggcactct cgaccatcgt ctcgctgtac 10561 gcactgcacc ggatcgacgg cgtcgacggc cgtcgtgcgc ggcggttcct gccggcgcga 10621 tggtggaagt tcaccggcat cgacgccctg gttatcggca cgctggcgct gtggcatgtg 10681 ttcggcgcca acacttccga cgacggttac ctgctcggca tggcccgggt ctcggagcac 10741 tccgggtaca tggccaatta cttccgttgg ttcggcgtcc ccgaagcgcc gttcggttgg 10801 tactacgacg tgctggcatt gttcgcgaag gtcagcaccg cgagcatgtg gatgcgcctg 10861 cccgcgctga tcgccggcat tctgtgttgg atggtgatca gccgcgaggt gatcccgcga 10921 ctcggtgttg cggtgcgccg caacaaggtt gccatctgga ccggcgggct cgtgttcctc 10981 gccttctggt tgccgtacaa caacggcctg cgccccgagc ccatcatcgc cctcggcgct 11041 ctgctcacgt ggtgctccat cgaacgcgcc atcgctaccg gacgtctgtt gcccgccgcg 11101 atggccgtgc tgatcgccgc attctcgctg gccgccggac cttccgggtt gatcgcgatc 11161 ggcgcgttga tcgccggcgc ccggccgatc ctgcagatcc tgatcgcccg cggcaaacgc 11221 gtcggcttcc tgtcccagat catgccgatt ctcgccgccg gaaccgtggt gctcgtcgcg 11281 gtcttcgcag atcaaaccct cgcgacagtt ctcgaatcga ccagagtgcg aacggccgtc 11341 gggccgaacg ttccgtggtt cgaggaacgg ttgcgttggg acgcactgat gaccatctcc 11401 cccgacggct cactggcccg ccgcttcggc atgttcgtca tgatcgtcgg actcgtcttc 11461 tgcgtcatga tgatcctgcg caagggccgg atcccgggca ccgctatcgg gccctcccgc 11521 cgaatcctcg gcatcgtgtt cgcgtcgctg ctcctgatgc agttcacccc caccaagtgg 11581 actcaccact tcggtgtgta cgccggtctg gccgccacgg tggccgtcct cgccgccgtc 11641 ggtgtgagtg cgtcgagcat gcgttccaaa cgaaaccgcg cgctgttcgc cgcgggcatc 11701 ctgttcatcc tcgctgtggc gttcacgagc tccaacggct ggtggtacgt ctcgagttac 11761 ggcgtcccgt ggtgggacaa gccgccgtca atcgccggca agggattctc gacggccttc 11821 ctcggcctca cgattctcgc gctgctgctg gccgcgtggt accacgtcat ggagccgcgc 11881 cggcgaaacg gcacagagga cagcgtcaag aagaccaggc gacttcgcct tctcgccccg 11941 tcaccgttga ccatcgcggc cggagcggtc gtgctgttcg aggtgctgtc cctgctcaag 12001 ggcgcggtcg cgcagtaccc cgcgtattcg atcggcaagt ccaacatcga atccgtcttc 12061 ggcggaagct gcggtctcgc gggtgaggta ctcgtcgagt ccgatccgaa cgccggcgtt 12121 ctgcaattga cggatcggcc caccgatctc gccggcgcgg gtgcattcgg tgcgagcgaa 12181 tcaaccgggt tctcgccgga cggggttgca ggcgacctca cggccgacgc agaagactcg 12241 acggcaggca gtgcaaacag cctcgacacc tcgacctcgc agtccggcac caccacgccg 12301 ggaaccggat ccggcaccgc cggtggctcg cagtcgacgg ccggcgtcaa cggcagcaac 12361 gtcgcgctcc cgttcgggct cgaccccgca aaaaccccgg tgctcggtag ttacggagca 12421 cctcagaacg cgtcactgac caccggttgg tattcactcc ccgagcgcaa cgacgccgca 12481 ccgctcctga ccgtcgcggc cgccggacgc atccgctacg tcaactccga cggcatcgtc 12541 acccccggcg cagtgctgca ggtcgagtac ggcaagaagc aggccgacgg gagcgtcgac 12601 gcactgggac gtgtcgatcc gatcgacatc ggcccgtcgc cgtcgtggcg caacctgcgc 12661 gttccgatgg atcagctgcc cgcagacgcc gacaccgtgc gtctggtggc cagtgacacc 12721 gacatcagcg ccgaccagtg gctggcggtc acaccgccac gagtgccgac catgcgcacg 12781 ctgcaggacg tcgtcggatc caccgatccc gtgctgatgg actgggctgt cggtctggcc 12841 ttcccgtgcc aacgtccggt ggatcacctg tacggcgtcg ccgagatccc cgactggcgc 12901 atcctgcccg accgcatcgg cgcggagtcc accaacgcct ggcaggacca ctacggcggc 12961 ggaccgctcg gctggactac cgaactgctc tcggccaggg cattgccgac ctatctggac 13021 aacgactggg atcgtgactg gggatcgctc gagcagtaca caccgctcga ttcggacgcg 13081 gttcccgcgc aaatgaacgt caccacagag acccgatcgg gcacctggac accgggcccg 13141 attcgttacc agtcgtaact gttacgcgtg gacctaccaa ccacctgggc acggtaggtc 13201 cacgctcagc cctgacatac catcggtagc cgtgcccgac gccgtgacag cttcacctca 13261 gacttcgagt tcgccgcctc ctgctggtca ggatgcccgc gagcgtttcc atcgcacgcg 13321 atgggtcgcg atcatcgccg gcttgctcgg cttcgtgctc gcactggcaa ctccgctgct 13381 tcccgtcgtg cagacgacgg cttcggtcaa ctggccgcag aacggagtga tcggcgacgt 13441 cgaggcaccg ctgatggcgc aggttcccat cgacgtcaac gcatcgatcc cctgtaccgc 13501 ggtcagctcg ctgccggagg gcggcggcat cttgctttcg acggcacctg cacagggcga 13561 cggcgcggca ctgtcgtcga tgttcgtccg ggtgtccgcg acgagcgtcg acgtgctcga 13621 tcgcaacgtc gtcgtcgctt cggcggcacg cgaggacgtc gagtccagtc gctgtggcgc 13681 catcgcgttc agctccgacg tcaaccgaac cacggcagag ttcgtcggac tgacgtatcc 13741 cgacggcaac ccgattcgtg gccagctcga cggtgacttc cgcccgcagg tggtcggcgt 13801 cttcagcgac ctgcccgacg gcgctgcccc cgagggcctc ggcttctcga tgacgatcga 13861 ctcacgtttc tcgtcgagcc ccagcgtctt gaagctggtc gcgatgatcg tggccgtcct 13921 ctcgaccatc gtcgcgctgg tcgccctggc tcgcctcgac ggcaccgacg gccgcaagca 13981 ccgacgcttc ctgcccgcac gctggtggaa gttctccggt atcgacggag tggtggtcgg 14041 cacgctcgtc gtgtggcact tcatcggcgc gaacaccgcc gacgacggtt acctcctcac 14101 catggcccga gtctcaccgg acgcgggata catggccaac tacttccgtt ggttcggcgt 14161 tcccgaggcc ccgttcggtt ggtattacga agtgctggcc gtgatggcga agatctcgac 14221 cgcgagcccg ttcatgcgtc tgcccgctct gctcgccgga atcctctgct ggatggtcat 14281 cagccgcgag gtcgtcccgc gtctcggccg ggcggttcgc cggagcaacg tcgccctctg 14341 gaccggcggt ctggtgttcc tgtccttctg gctggcgtac aacaacggtc ttcgtcccga 14401 gcccatcgtg gctctcggcg cactgctcac ctggtgctcc atcgagcgcg ccatcgccac 14461 cggacgtctg ctgcccgcgg ccacggcaat cttgatcggc gccttcactc ttgccgccgc 14521 acccaccgga ttgatgtgta tcgcagccct tctcgccggt gtgcgcccgt tggtacgcat 14581 cgtcgtcaaa cgtcaccgac tggtcggcac actgccgctt ctcgctccga tcgccgctgc 14641 cggaaccatc gtgctggtgg tcatcttcgc cgaccagacc tttgccggtg tcatggaagc 14701 cacgcgcgtc cgaacgatca tcggccccaa tctcgagtgg taccaggact tcctgcgcta 14761 ctactacctc ttcgtccaga cagtcgacgg ctcggttgcc cgacgcttcg cgttcttgac 14821 gatgatcctg tgcctcttca cgacgctctt cgtgttgttg cgccgcggcc gcgtccccgg 14881 cgcggcaacc ggtccgtcgt ggcgcctggt cggcgtcgtc ttcggcacga tgttcctgat 14941 gatgttcaac cccaccaagt ggactcacca cttcggtgcg tacgcgggca tcgccggttc 15001 tctcgccgcg ctgaccgccg tggccgtgtc cgcgtccgcc ctgcgctcgc gtcgtaaccg 15061 atcggtgttc gtggccggac tgctcctgat gctcgcgttg acgttcgccg gcatcaacgg 15121 ctattggtac gtctcgagtt acggcgtgcc gtggttcgac aagaccatct cctacgacgg 15181 ccgtgaatcc aacaccctgt tcctcgcgct ctttgctctc gccttggcgt ttgccgcctg 15241 gcagtacctg cgtgagggat tcgcagcccc gcccgagaag ccgaacacgg ccaagggcag 15301 acgaattcgc aaattcgcgg ccgctcccct caccgtgatt gccggtctga tggtcctgtt 15361 cgaggtgctc tcgctactca agggcgcagt gtcgcagtac ccggcgtact cgctgggccg 15421 aagcaacatc gaggcactcg cgggcaagac ctgcggcatg gccgaggacg ttctggtcga 15481 gaccgacgtc aattccggga atctgcggcc tctgaccgct cccggattca acgccgagga 15541 tccgttgtcc ggagttgatt cgaagggctt ctcccccaat ggggttccca gcgatctgac 15601 tgcggattac atcgaagtca agcagggcat gggcaatacc gacagccaga gtgtcggtcc 15661 caccttcgcc accggttccg gtgccggaac cagcggcggc accggcaacg tcggcgtcaa 15721 cggcagcacg gccaagctcc ccttcggcct cgatccgtcg aaaacgccgg tcatgggcag 15781 ctaccagccc ggcgtgcagg aacctgcatc cctcatctcg agttggtacg gattgcccac 15841 tcgcagtgaa gaatcaccgc tggtggtcat gtccgtcgcc gggcgtgtgt ggtccgtcga 15901 caacaccggt gcgatcacgt acggccagtc acttctggtc gagtacggca agactcagcc 15961 cgacggaacc gtgcaggttc agggttcgta catgccgcga gacatcggac ccgcgccgtc 16021 gtggcgcaac gtccgtatcc cgatcgacga actcgcgccg gacgcggacg ccgttcgggt 16081 ggtcgcgttc gatcccaacc tcacgggcga tcagtggatg gcattcacgc cgccgcgcgt 16141 gcccaagctc gagtccctga actcgtacat cggcaacgag cagccggtcc tcctggactg 16201 ggctgtcggc cttcagttcc cgtgccaacg tccgttcaca catcagaacg gtgtggccga 16261 gatgccgaac ttccgcatcc tcccggaccg tcctcttgcg gtcagttcca ccgacacctg 16321 gcagtccgcg gacaacggtg gcccgctcgg attcaccgag gttcttgccg gtgcgacgac 16381 ggttcctacg tacctgaagg acgactgggc gcgggactgg ggatcactcg agcggtacga 16441 ccggtacttc cccaatgcgg ttccggcaga ggtggagacg ggcaccgcaa cccgctcggg 16501 catgtggatg cccggcgaga tgcgagtgca ctagcctgcg ctacctactc gggtgactgc 16561 tcgggtgcga cgtacggaga cggccgagac cgctccgaca acgacgacgc acccgagtag 16621 ttgcccaacg cctggccgtt cgccgagcag cacaactgcc agcagcacgg cgagaaccgg 16681 ttgcatgagc aggagcgtcg cgcccacctc ggcgggaagc cgagggagcg agttccccat 16741 cagcatccag ccgaacacct ggccgaccag tgccagtgcc gcgagccagc cgaacgcttc 16801 ccagcccggg acgaaatcga tccggcccca cagtgatccg atgacggacc cggcgatgcc 16861 cgcggacgtc gtcgagatca acacctggct cgctgcccga tccgcctcgc ccgtccggcc 16921 gaccacgaag atgtagccgc cgtaggcgat tccggagacg agcgagagcg ccgttcccca 16981 catcaagtcg tcgccggttc ccccgccccc gaacacgccg cccgccaagg cgattcccgt 17041 gaacatgaac ggcagggcga agacgaaccg catcggcacc cgatggccga acaccaacca 17101 ggacagtgcg ggcaccacga ccacctgcac gttcacgacg acgctcgcca tccccgcgcc 17161 gatcatcaga atcgactgcg accacaacgc gaaatccagt ccgagcagca gaccgccgag 17221 cacctgcaga acgactgccc gccggctcgg cttgcccacc cggcggtact cccgccatgc 17281 caaccacaac agcggcggca aggccaggaa gcaacggaag aagacggcgg tcgagggccc 17341 cacatcggcc agcttgatga ggagcgaact gatcgagatc gcagctgcgc ctccgacgac 17401 cagcagtcga gggtcgatgc gcccccgagg agttcgggtg ggtgtcgatg tctgcgcggt 17461 cgcggaggtc agtgtggtca ctcgacaatg ttcctgccgc taactattca gcacaagcaa 17521 atgttcagac cgtatattcg gtagcattac tactgtgttg aatctcgaaa gacttcgcgc 17581 cctgcacgcc gtcgccgaga acggatcagt agcggctgcc gcccgcacct tgcatgtcac 17641 accctccgga atttcgcagc agttgaacaa gctcgagcga gaggtcggtg ttccgctcct 17701 cgaaccgcag ggccgcggtg tgcgactcac cgaagcgggc cgaatcctcg cgcgccgaac 17761 cgcagaggtt ctctcgacgc tcgcccaggc cgaggcggaa atcgcgtcgc tgcagagcga 17821 ggtgacgggc cgcgtacgta tcggcgccct ggtctccccc agcaggacag tgctgccgcg 17881 agccatcgcc gaaatcaggc acgcgcaccc ccagctcgaa atcaccttca acgaaggcga 17941 atccgaagaa ctgctccccg cactgattcg ccgcgacctc gacgtcgtgg tggtcgacag 18001 ttggagcact ctgcccgtcg aacttcccga cggactctcc ttcacgcccg tgtacgacga 18061 cgtggcgctg ctcgctctcc cgacgtcaca tccgctggcg gagaacaagg tcgtcgcgct 18121 cagcgagctg tccgagcatg cctgggcgac gtggacacgg ggaacggact ttcacacctt 18181 caccgtccgg accctgcgcg cgcaggggtt cgacccacga atcgagtacg aggtcgccga 18241 gtttcccacc caggtcgaat tcgtcgctca gggcctcgcc gtcgcattga ttccacgtct 18301 ggcgagagtt gtaccgccgg aaggtgttcg aatgctcgac acggttccgc cgctcggccg 18361 agacatctac ctcgcctggc ggacagacag cgaaaggccg gccgtcctgg cggcgataga 18421 agcgctacgc cgccagttcg acgccctcgg tgacaaaaag aactagagcg gcatcaagtt 18481 gtgcttgcgc gggttcttga agatcgtctt gtccgcgagc aacttcagag ccttacggat 18541 ctcgagacgc gtctgcgaag gctcgatcac cgcgtcgatg tatccgcgct ccgccgcgat 18601 gtacggcgtc gcgacgaact cgttgtagaa gttgatcagc tgagcacgca ccgcgggtgc 18661 attctcgccg gcctcggcaa gctgacgccg ccccatgatg ttgacggcac cctcggcgcc 18721 catcacggcg atacgagcgg tcggccacgc gaggttgatg tcggcaccga gctgcttgca 18781 gcccatgacg gcataaccgc cgccgtacgc cttacgaacc accacagtca ccttcggcac 18841 agtggcttcg atgtacgaga acaggaaacg cccgccgcgc ttgatgacgc cgaccttttc 18901 ctgatcgacg ccgggaagga agcccggtgt gtcgacgacg aagacgagcg ggatgttgaa 18961 agcgtcgcac agacgcacga agtgggcggc cttgtcggag ctgtccgcgt cgagggcgcc 19021 gctgaggtac gtgggctggt tggccacgac accgacgggc aggccgtcga cgcgggagaa 19081 tccggtgatc acgttgtgcg cgacctgggc tccgatttcg tggaaagtgc cgtcgtcgaa 19141 gatccgcaga atgatgtcgt gcatgtcgta gccggcattg tcggcatccg gcatgaacgc 19201 attgagttcg agatccgact cggtgatctc gggttcgagg cccgggttga tcagcggcgc 19261 cttctcctgg cacgacgacg gcatgaagct caggtactca cgcacccagt cgaaggcagc 19321 cttctcgtcg ggagcgacgt gatggatgtt tccgtactcc gcctgcttgc gggctccacc 19381 caagtcctcg aggctgacct cttcgccggt gaccgacttg atgacgtcgg gtccggtgac 19441 gaacatgtac gactcttcgg tcgcgaccac gacgtccgtg ttgatcgggg cgtacacggc 19501 accgccggcg catttaccga ggatgaccga gatctgcggg cacaggccgg acaacggctc 19561 ctgacgtgaa cccatgttgg cgtaccaggc caacgaggaa acggcgtcct ggatgcgagc 19621 tccaccggaa tcgttgatac cgacgaccgg gcagcccacc ttcagcgcaa aatcgttgac 19681 agctgcgacc ttacggccga acatctctcc ggcggcaccg ccgaacaccg tctgatcgtg 19741 cgcgaacacg gctaccggac gcccgtcgac ggttccgtga ccggtcatga cgccgtcgct 19801 gtacgggttg ccctcgcccg ccatcttcac cagggcaccg atttcgatga agctaccggg 19861 gtcgagcaac atgtcgatgc gctggcgcgg cgtgctgtgc cctgctgcat cgcgcttggc 19921 aatggcccga gccgagccgg gttcctttgc cttctccaac ttttcgcgga gttcagcgag 19981 cttctccgcg gtggttgtcg tcacttctga actccggttt ccgctgcttt ggtctgagct 20041 gtctcgatct gggccagctt ggtggtgagg tctgccgcaa ccttcgcgat gtacggctcg 20101 tcgacgatct gcaggtggtc cccgccgatg tagacgacct cgaggttctt cacgtagtca 20161 ccccagccac catccgcctt gcgggtcttg aatgcaggct cgagcgtcat cagctcgtcg 20221 tggtacttgt cagccatgta gagcacgacg tcgccgtcgt aactgctgaa ctcggccgtc 20281 tggatggcgc gattgtccaa ccacgacgtc cgctgatgct cgatgatgcc gccgggaatc 20341 ttggcgccgc tcatcttgat catgtccatc aagatctgga tctgatcctc gtcggcttcg 20401 gtggaagcca gaacgtcaag cggcagcggc acatccaggt tgtaggtgcg cttggcgaac 20461 ttgccgtagc gctcccaacg cttgcgtcgt tccgcctcgg tgtccggcac gacctcgccg 20521 gccatgacgg tgtcgagcag cccgaccaca cgcacgtcgg cgccctgctc gcgcagcaac 20581 ttcgcgaccg catacgacat cacgccaccg aacgaccagc cacacagcac gtacggcccg 20641 tcgccctgga tctcacgcag cagcggaacg taagcagcag cgcgggtttc gatcgagccc 20701 tcgacccgct cgaatccgta catcggcgtg ccggcgggca ggcgcttgag cagaggctcg 20761 tacgtcaccg tcgaaccacc ggcagcatgg aagacgaata ccggtacggc agtggaacct 20821 tcgggacggg cacgcagagt acgtacgagt ccgtcgatct tgccgtcgtc ctcgaggtac 20881 tggcgaacga cgtccgcaag ctcttcgatg gtggtggagt cgagaacgtc gtcgagagtg 20941 atctcgccgc cggcacgctc ggaaagccga gcagcaagct tctcggcgac ctcgtcaccg 21001 acgatcggca gatcgttgaa gatgcccttg gccgacttcc cggtgacaac cgcccacgtc 21061 gcaaacgtca agcgctcggc cgcatctcgc ggcggaacgt ccgagcctgc gtcgtcggca 21121 gttccggcac gcgaaggatc agcgggcgcg gcagccgccg caacgggagc agtcgccggc 21181 agttccactg ccacctcggc gggagcagcg tcctcgtcag cagcgtcggc cgccaacttc 21241 tccgcggcct gcttgtcggc catcgcctga acctcttcgc gattgtcgat cgcgtagcgc 21301 aggtacttgt tgacctcgtt gaggctcgcg tccttgactg cctggagctg gagctgcgga 21361 atgtcgaact cgtactcgac gcggttcttg atacgcatcg ccatgagcga gtcgagaccc 21421 agttcgatga gcggaacctc ggccggcaga tcctccggcg agtaccccat cgactcggct 21481 accacgatct tgaggcggtc gtcgaggctc tgcgaaccgt tcggatccca cttgtctccg 21541 gcgtcttcga cgacctcggc cagggattcc atcggcgcac tggtcttgac cggcgcgctg 21601 acgaccagct cgggcagcgg ctcacccgac gtgacgacgg cgtcgaagag cagacggaac 21661 gtagcaccct cacgggcgtg cacctgcacc gacgctccac ccggatgcgg gttgagtgtc 21721 gtggtcaggg tcgcagcgcc ggccagctca ccacggggaa cggcagcggt gagagcgaca 21781 tccgagagca cctgtccggc agcagcgctc acgagcacag ccagatcggt gacggcggat 21841 gcgtcgacct cccacacgtg gcggccgtcg ggcagagcga cgtgcgaacc gggtacgcga 21901 gccgaaccgc cggcactgac gcgaatgtcg agccaatacg gcttacgcag gaatgcggta 21961 cgcggaaccg aagcgaaatc gcctgcggga agcagagact cgaggttcac ggcatggccg 22021 tgcacgtaca gctgcgcgag agcggcaaga acacccgcgg actcgtcttc cttacgcttg 22081 agcgtctgga tgagctccat gtcgtgcagg cccgaatcga aagcggtagc cgccaccgac 22141 atcagcgtca ccgggttggg tgcaagctcg acaaaagtgg tgtggccgtg ggcaactgca 22201 ccgcgtaccg cattggtgaa gtacacgctg tggcgaagac ccttgaccca gtacgcctct 22261 tgatggatcg gctcgtgacc gggacggtag aaagtgtcct tgtcgacgga cgagtagacg 22321 ccgagcttca acgttgtcgg ctcgataccg gccaactccg cggcaagctc gccgagcaac 22381 ggatcgacct gtgaggtgtg gctggcaccc ttggtctgca ggacacgcgc catcttgccg 22441 tcggcctcgg cggccgcgac gatcgcctcg atgtccggct gtggtccacc gatcaccgtg 22501 tgcgtcggag ctgcgtaaac acagacctcg agcttggggt acgtgggcag tagcgcctcg 22561 atctcggatg cgctgtactc gagcaaagcc atcagacgga tgtcgtcacc gacgagtgcg 22621 ccctcggcct cacccatcag ccgtgaacgt gaacagatca cgcgcacagc gtcttccagg 22681 ttcagaccac cggacacgta tgcggcagcg gcctcaccca tcgagtgcgg aaccacggct 22741 tcggcctcgg cgccgtggtg acgcagcaac gcggccagac cgacctggat ggtgaagatt 22801 cccacctggg cggtctcgac gttgtactcg atcgaatcgt cgaggaacat ctcgaccatc 22861 gagtaaccgg cctcgtcctg gatcagcgcg tcgacctcgt cgacggccgc cttgaaggcc 22921 gagttctccg tgtagagctg cttggccatc ttgcggtgct gcgagccgaa gcccgagaac 22981 acccacaccg cgcccttggg cgacggcgag tcggcggaga agactccttg agcaggcttg 23041 cccgcggcga cggcacgcag cgagctgatg gcctcggagc gcgtcttcgc cagaacagcg 23101 gcgcgcgagc gtccgtggtt gcgacgcgcg agtgtgcggg cgacgtcggc gaggggcgtc 23161 ttgcttccct cttcggtttc gagccagtcg gccagatcag cggctgcgcg gcgacgacgc 23221 gacggcagcg caccggaaac ggccagcaca acggtgctct cgttctctgc tgccggttcg 23281 tcgaccaccg gggcatccac aaccggttca tcgactaccg tctcggcagg cacgtattcc 23341 ttgaccacga cgtgcgcgtt ggttccgccg aaaccgaaac cggaaacacc ggcgacagcc 23401 ttgccggtgt agcgcggcca gtcggtggcc tcgggcgtca cctgcaggtg cgacttctcg 23461 aagtcgatgt gcgggttcgg gcccaggtag ttgatcgtcg cgggaatctt gttttcctgc 23521 atcgccagaa cgaccttgat caggccggcg gcgcccgcag ctgcttccag gtgcccgaag 23581 ttggtcttcg cgctaccgag cagtgccggc ttgtcgtcgt cacgaccacg accgacgaca 23641 cgactgagcg cgtcggcctc gatgggatca ccgagatcgg tacccgttcc gtgcgcctcg 23701 atgtagtcga cggtggtcgg caagattccg gcgtcgcggt acgcgaaacg caacacgtcg 23761 gcctgggcat cgggattggg tgcgagcaga ccgttggaac ggccgtcctg gttgaccgcg 23821 gatccggcga tcaccgcgag gatggaatct ccgtcacgct cggcgtcttc gaggcgcttg 23881 agcacgacga gtccgccgcc ctcactgcga acgattccct gagcctgagc ggagaaggca 23941 cgcagttttc cgtcgggagc gagcatcccg gtctgatcga aaccgagggt tccgggaggg 24001 gccagcagca tgttgacgcc accggccagc gcgatgttgg agtcaccgct gcgcagcgag 24061 cgcacagcct cgtgaacggc aaccagcgaa gacgaacacg cggtgtccag agcgatggac 24121 ggtccacgga agtcgaagaa gtacgagacc cggttcgcga cgatggcagt cgacgttccg 24181 gtcaacgcgt acggatgcgc cgtcgtcgga tcactgaccg cgagcagctg gtagtcgttg 24241 gcggaactgc cgatgaaaac accgacctgc ttgcccttga gcccactggc cggaatgcga 24301 gcgtgctcga gtgcttccca cgcgagttcg agtgcgaggc gctgctgcgg atcgacgttg 24361 acgacctcga gcggagacat cgcgaagaac tcggcgtcga aacccttgac gtcgtcgagg 24421 tacccgccct tggtgttcgc gttctcgacc gcggccttga tggcgggatc cgacatgaac 24481 tcggcccagc ggtcctcggg gaggtcgctg atgccgtcgc gtccgtccgc cagcatttcc 24541 cacatgtccg aaggcgtgtg cccggcaccg gggaatcgtg tggaaagtcc gacgatggcg 24601 atgtcgtgag cgtccgtcgc gccgcctgag acgtagtacg aggcgtcgac ggtctcctcc 24661 ggcgcctcgg gctcaccttc gatgatccga gtagccagcg aagcgatggt ggggtgttga 24721 taggcaaccg tggcggtcag cgtgacgccg agcagatcct cgatgtctcc gctcagagcg 24781 actgcgtccc gcgaggcgag cccgaactct tccatcgggc gatcgtccgt gatcgaaccc 24841 gccggctgac cggtcgcgtt ggcgatccaa ttgcgaagcc actcacgcag ctgcgcgaca 24901 ctcatctcgc tcacaacgtc tttgctctgc gcaccatctt gttcaaccat caactcacca 24961 agccaccgat catgaaggga ctgctcctca aacgctatcg gggaatgcgg tctgctgata 25021 gccgcctcgc aacgttccct cgatatagct cgccttacac gcgcggcgag cgatcttgcc 25081 gctggacgta cgcggaatcg aacccgcggg gacgagcagg atgtctcggg ccgtaacacc 25141 gtgacgggaa gaaatcgccg cacgcacggt gtccgcgatc ggctg //