LOCUS NZ_JARDXE010000006 46111 bp DNA linear CON 01-APR-2024 DEFINITION Rhodococcus qingshengii strain HQ HQ1_scaffold6, whole genome shotgun sequence. ACCESSION NZ_JARDXE010000006 VERSION NZ_JARDXE010000006.1 KEYWORDS WGS; RefSeq. SOURCE Rhodococcus qingshengii ORGANISM Rhodococcus qingshengii Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae; Rhodococcus; Rhodococcus erythropolis group. REFERENCE 1 (bases 1 to 322110) AUTHORS Hu,J. and Xu,J. TITLE A novel hydrolase synthesized by Rhodococcus erythropolis HQ is responsible for the detoxification of Zearalenone JOURNAL Unpublished REFERENCE 2 (bases 1 to 322110) AUTHORS Hu,J. and Xu,J. TITLE Direct Submission JOURNAL Submitted (23-FEB-2023) Grain and Oil Risk Assessment Laboratory, Jiangsu Academy of Agricultural Sciences, No. 50, Zhongling Street, nanjing 210014, China COMMENT ##Genome-Assembly-Data-START## Assembly Date :: MAY-2022 Assembly Method :: ABySS v. 2.1.5 Genome Representation :: Full Expected Final Version :: Yes Reference-guided Assembly :: GCA_002079265.1 Genome Coverage :: 470.0x Sequencing Technology :: Illumina NovaSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_029076895.1-RS_2024_04_01 Annotation Date :: 04/01/2024 06:35:53 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,927 CDSs (total) :: 6,855 Genes (coding) :: 6,768 CDSs (with protein) :: 6,768 Genes (RNA) :: 72 rRNAs :: 1, 1, 1 (5S, 16S, 23S) complete rRNAs :: 1, 1, 1 (5S, 16S, 23S) tRNAs :: 66 ncRNAs :: 3 Pseudo Genes (total) :: 87 CDSs (without protein) :: 87 Pseudo Genes (ambiguous residues) :: 0 of 87 Pseudo Genes (frameshifted) :: 33 of 87 Pseudo Genes (incomplete) :: 63 of 87 Pseudo Genes (internal stop) :: 12 of 87 Pseudo Genes (multiple problems) :: 18 of 87 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 19:34:22 NOTE :: This is a single region extracted from a larger record! Orig. start :: 115954 Orig. end :: 162065 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to JARDXE010000006.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..46111 /candidate_cluster_numbers="1" /contig_edge="False" /product="T1PKS" /region_number="1" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /tool="antismash" cand_cluster 1..46111 /SMILES="CC(=O)C(=O)O" /candidate_cluster_number="1" /contig_edge="False" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="single" /product="T1PKS" /protoclusters="1" /tool="antismash" protocluster 1..46111 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[20000:26111](-)" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" /tool="antismash" proto_core complement(20001..26111) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" gene complement(106..519) /locus_tag="PXH69_RS11020" /old_locus_tag="PXH69_11015" CDS complement(106..519) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746551.1" /locus_tag="PXH69_RS11020" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11015" /product="hypothetical protein" /protein_id="WP_007731530.1" /transl_table=11 /translation="MTKLIDCEVGSVLPSLELPLDRTLIVATAISSQDFEDVHHDPGKA QDRGTPDIFMSINTTNGLIDRYITDWSGPGSRIVKTSLRLGVPNFPGDTMTFTGKVTAA DGRALTVTVLGQNARGTHVTADVTLEPVERVIA" gene complement(516..944) /locus_tag="PXH69_RS11025" /old_locus_tag="PXH69_11020" CDS complement(516..944) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943933.1" /locus_tag="PXH69_RS11025" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11020" /product="OB-fold domain-containing protein" /protein_id="WP_007731532.1" /transl_table=11 /translation="MSETGSRNTAVPRLTVTDDNDFFFSAAKEGRLEIQRCADCKTLRH PPAPACPECRSFSWDTVESTRRCTLHSFTVIHHPKDPAFEYPLAVGLVDLEEGTRLVAD IAGIDHEELEFGMELEVAFSEHAHGEMLPQLRRRGSVQ" gene complement(941..1519) /locus_tag="PXH69_RS11030" /old_locus_tag="PXH69_11025" CDS complement(941..1519) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731535.1" /locus_tag="PXH69_RS11030" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11025" /product="MaoC family dehydratase N-terminal domain-containing protein" /protein_id="WP_007731535.1" /transl_table=11 /translation="MQSLQTQFPNFIGAEAEPPRVARYAVNEAMIRNWVEAHDDRNPIY VDAEAARSTGRRDVVCPPAMISTWVMAGYRRYRQVQQLRADGASEDFAYSRLLGLLDEA GYTSVVATNVEQEYFAELSPGDHVTAYFTIEAISPFKQTALGHGCFITLFKKYVDQDGK TLVEERFRLLRFKPDAQTDTKPEAQEVIA" gene 1585..2298 /locus_tag="PXH69_RS11035" /old_locus_tag="PXH69_11030" CDS 1585..2298 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1057: TetR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731536.1" /locus_tag="PXH69_RS11035" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11030" /product="TetR/AcrR family transcriptional regulator" /protein_id="WP_175280092.1" /transl_table=11 /translation="METRDLTDELVRAGAIGQDCATFDAGSPAPPKPCPEQDRQPVEIS VASPDRREKILESSAELFARKGVATTTVREIGDAAGVFSGSLYHYFKSKNAIVAELMRG FITDIQLRFDQVEKTANDPEEVLRGLIRETLVVIELHPHPTAIYQNDRAYLRDNDLLQS VDGPSRQVREHWMKAIAEGVDQGIFRKDVAPEIFYRSVRDTLWSTTHWPDRQKYTTDEF ADLMITLFLSGFRVA" gene complement(2285..3757) /locus_tag="PXH69_RS11040" /old_locus_tag="PXH69_11035" CDS complement(2285..3757) /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1005: Drug resistance transporter, EmrB/QacA" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020723627.1" /locus_tag="PXH69_RS11040" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11035" /product="MFS transporter" /protein_id="WP_007731537.1" /transl_table=11 /translation="MTTLDRPPGTPAVTTSDAGLAQPRSRFLFPIVVAAAVFQAVLQTV IVPLLPELPHFTGAGRTAVSWLVTVTLLVGAVVTPIFGRLADMFGKKKMLLVAFSMMTL GSMLCALSSDIAVLIFARALQGAGSAVIPIGISMLRDELPRNKVNGAVAMMSSTLGVGT ALGIPFSAMIAQYSNWHVLFWVTTAIGLSVTLAAVLFIRESEPNPSGRFDGVGAVGLSA AMIALLVPITQGSSWGWTSGAVISMLAASAVLFTLWVIQQRRNVNPLVDVRALVKRAVL IPHLAALLVGFAFFGNTLITTQLLQGMKGPGAGYGLSIIAAALCQIPASIAMVLFSPVA VRITDRFGSRTAMLTGAVFLAGGYGIHAVAGKPLWGVVAALGITAVGTAIVYSTLSLLI LVAVPRQRLAAANGVNSLLRTSGSTICSATVATILAAFVISGSEHSTSWTGFSVAYLVC AGCAVVVFAVSILLPQGRTPKHLDLPDLVRRP" misc_feature complement(3833..3848) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 17.13" /tool="antismash" gene complement(3844..4413) /locus_tag="PXH69_RS11045" /old_locus_tag="PXH69_11040" CDS complement(3844..4413) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1215: TetR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731538.1" /locus_tag="PXH69_RS11045" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11040" /product="TetR family transcriptional regulator" /protein_id="WP_007731538.1" /transl_table=11 /translation="MSGTEQGQQVRRTSEQTRAQIIASAGKAFATRPYREITLKDIAED AGVSAPLIIKYFGSKEQLYDELVDFRAAAVTVFDAPNDSLGERMVSLFTKPLESYKPLS MSLLFMSGVSEESNRKLRENYSTQMIDTLAARLSGPDARLRAELAMSMVVGVAIMRRRM MAGHATGTQDEVVALYAPLVQKLLDG" gene complement(4413..5033) /gene="recR" /locus_tag="PXH69_RS11050" /old_locus_tag="PXH69_11045" CDS complement(4413..5033) /GO_process="GO:0006281 - DNA repair [Evidence IEA]" /GO_process="GO:0006310 - DNA recombination [Evidence IEA]" /codon_start=1 /gene="recR" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731539.1" /locus_tag="PXH69_RS11050" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11045" /product="recombination mediator RecR" /protein_id="WP_003943917.1" /transl_table=11 /translation="MYEGPVQDLIDELGKLPGVGPKSAQRIAFHLLSVEPPEIDRLKNA LQRIRDGVQFCTVCGTVSDQEKCRICADARRDRTVICVVEEPKDVQAVERTREFKGRYH VLGGALNPLSGIGPDQLRIRELLARIANQEDGVDVSEVIIATDPNTEGEATATYLVRMM RDIPGLTVSRLASGLPMGGDLEFADELTLGRALSGRRELSRNA" gene complement(5046..5384) /locus_tag="PXH69_RS11055" /old_locus_tag="PXH69_11050" CDS complement(5046..5384) /GO_component="GO:0005737 - cytoplasm [Evidence IEA]" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0008150 - biological_process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005248645.1" /locus_tag="PXH69_RS11055" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11050" /product="YbaB/EbfC family nucleoid-associated protein" /protein_id="WP_003943929.1" /transl_table=11 /translation="MQPGGAPDMSALLAQAQQMQQQLMAAQQEMAQAEVTGQAGGGLVV ATVKGTGEVVGLQIDPKVVDPEDVETLQDLVIGAIEDASRKAQEVAAEKLGPLAGGLGG GLPGLPGF" gene 5494..6294 /locus_tag="PXH69_RS11060" /old_locus_tag="PXH69_11055" CDS 5494..6294 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943843.1" /locus_tag="PXH69_RS11060" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11055" /product="Rv3717 family N-acetylmuramoyl-L-alanine amidase" /protein_id="WP_003943843.1" /transl_table=11 /translation="MASRVFRSTALIAVVGAGLLSAACTIPTETAEATTSVEVSPLSTV AADVPAALTGKVVFLDPGHSGANDDSINTQVPTGRGGTKNCQTTGTNTDAGFPEHTFNW EVASLVKSELEGQGATVVLSRPDDISVGSCVDARAEAANSSGADVVVSIHADGAAAGAE GFHVCYSAPPLNAVQAGPSVTFAETMRDSLVTAGLTPSTYIGDDGLAPRADLTGLNLSQ RPSILVELGNMRNADEAARMTSPDGQQEYASAVTSGVTAFLTTP" gene 6379..6675 /locus_tag="PXH69_RS11065" /old_locus_tag="PXH69_11060" CDS 6379..6675 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746546.1" /locus_tag="PXH69_RS11065" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11060" /product="hypothetical protein" /protein_id="WP_083059296.1" /transl_table=11 /translation="MGPILQVDFAALQQLSADLSRIADQISGIDSAGPIFEAAAALNSS AVAAVSTGNAGVIADAYRHLATQLGLMASGTADAARLFDAAEAEVVSELRGAY" gene 6675..8186 /locus_tag="PXH69_RS11070" /old_locus_tag="PXH69_11065" CDS 6675..8186 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731543.1" /locus_tag="PXH69_RS11070" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11065" /product="alpha/beta hydrolase" /protein_id="WP_275231746.1" /transl_table=11 /translation="MQPTVSQLRAWSPEQLRTIASELIDIDRQIEALGNDAGRSIDGVR EFWLGQASSAAAVQWSGISLASSRLSIAARVVADLYAGASNTIGAARKSVLDLVEEATL RHGLTVSDSGAVSAPETKQPWNLADAMQDSEDATAAQVFQQKISTALTALDDEDNRAAT ALGEAFREIGSLLGNQPDRLDRTVVDIIDGRSTLPGTPAELHRLWESLTPNEKDALARW DPSIGSRDGLPALDRDYYNRRYLSALEQLPDRTVAAGYTAVRGELRPDTFLLSVTDGHA VVAVGNPDAAGNVATLVPGTGSGLSGVGGDLQRTKAMYDAAVRAAPTEATSVILWSGYD APPGIPDAASDRYATSAAPRLDSFQDGLRTSHDGPPSHNVVIGHSYGSTVIGAATTRGA SLDVDELVLVASPGVDAERVNELSLDGVDSDEVARHVHSTTAFWDPVQLIPTILGVHGF DPSDPEFGAQVFAGSPGEPGFGVHSDYWESGNPALTELGRIITGP" gene complement(8241..8675) /locus_tag="PXH69_RS11075" /old_locus_tag="PXH69_11070" CDS complement(8241..8675) /NRPS_PKS="Domain: Polyketide_cyc2 (6-143). E-value: 2.4e-19. Score: 62.1. Matches aSDomain: nrpspksdomains_PXH69_RS11075_Polyketide_cyc2.1" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943959.1" /locus_tag="PXH69_RS11075" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11070" /product="SRPBCC family protein" /protein_id="WP_003943959.1" /transl_table=11 /translation="MGQVNAMSSTVVTAAPDKVLAALSDYETVRPRILSEQYLDYKVVE GGQGDGTVAQWTLKATEKRSRNVKATVTVDGNVITEKDANSSLVTTWTVAPNGTGTTVT TLTQWQGATGIGGFFERTFAPKGLQRIQAQVLDNLKRELV" aSDomain complement(8247..8657) /aSDomain="Polyketide_cyc" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11075_Polyketide_cyc2.1" /domain_subtypes="Polyketide_cyc2" /evalue="2.40E-19" /label="PXH69_RS11075_Polyketide_cyc2.1" /locus_tag="PXH69_RS11075" /protein_end="143" /protein_start="6" /score="62.1" /tool="antismash" /translation="MSSTVVTAAPDKVLAALSDYETVRPRILSEQYLDYKVVEGGQGDG TVAQWTLKATEKRSRNVKATVTVDGNVITEKDANSSLVTTWTVAPNGTGTTVTTLTQWQ GATGIGGFFERTFAPKGLQRIQAQVLDNLKREL" misc_feature complement(8812..8827) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 17.13" /tool="antismash" gene 9014..10417 /locus_tag="PXH69_RS11080" /old_locus_tag="PXH69_11075" CDS 9014..10417 /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /GO_function="GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746543.1" /locus_tag="PXH69_RS11080" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11075" /product="FAD-binding oxidoreductase" /protein_id="WP_042447764.1" /transl_table=11 /translation="MGFEQHREGVERLLASYRAIPADASVRLAKKTSNLFRARAKTSAP GLDVSGLAGVIAVDAQARTADVAGMCTYEDLVDATLPYGLAPLVVPQLKTITLGGAVTG LGIESTSFRNGLPHESVLEIDVLTGSGEIITATPDGEHAELFFGFPNSYGTLGYSTRLK IALEPVKKYVALRHVRFDSLKKLEETMDRIVTEREYDGIAVDYLDGVVFTDSESYLTLG AQTDEEGPVSDYTDQDIFYRSIQHSSLTQPKTDRLTIRDYLWRWDTDWFWCSRAFGAQN PKIRRFWPKQYLRSSFYWKLIALDHKYDIGDRLEKRKGKPPRERVVQDVEVPIERTADF VSWFLEEIPIEPLWLCPLRLREPSPAAASASRPWPLYPLEPKRTYVNIGFWSSVPIVPG EREGAANRLIEEKVSDFDGHKSLYSDSYYSKEDFEELYYGGDRYIGLKERYDPKSRLLD LFSKAVQRK" gene 10414..11715 /locus_tag="PXH69_RS11085" /old_locus_tag="PXH69_11080" CDS 10414..11715 /EC_number="2.1.1.-" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1089: methyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746542.1" /locus_tag="PXH69_RS11085" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11080" /product="class I SAM-dependent methyltransferase" /protein_id="WP_003943932.1" /transl_table=11 /translation="MTTFKDSKSQDKLSIAEILETLSDGMLPLRFTAYDGSTAGPEDAD YGLHLKSTRGTTYLATAPGDLGMARAYVSGDLEAEGVHPGDPYEILRIMGDELHLKRPS ALTLASITRSLGWDLLRPIAPPPQEHLPRWRRVAEGLRHSKTRDAEVIHHHYDVSNTFY EYVLGPSMTYTCAAYDNAEQTLEEAQENKYRLVFEKLGLQKGDRLLDIGCGWGSMVRYA ARRGVKVIGVTLSREQADWAQKAIEDEGLADLAQVRFSDYRDVAETGFDAVSSIGLTEH IGVGNYPAYFEFLKGKLREGGRLLNHCITRPDNRSSAKAGGFIDRYVFPDGELTGSGRI ISEIQNVGLEVRHEENLREHYALTLAGWCQNLVDNWDACVAEVGEGTARVWGLYMAGSR LGFERNVVQLHQVLAVKLGPKGEAHVPLRPWWKA" gene complement(11752..12783) /locus_tag="PXH69_RS11090" /old_locus_tag="PXH69_11085" CDS complement(11752..12783) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943834.1" /locus_tag="PXH69_RS11090" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11085" /product="hypothetical protein" /protein_id="WP_275231747.1" /transl_table=11 /translation="MTTSHGGSEFLRILDAQSGLVRQQQLSSFGYNRGRNFLDRGEWQR VLQGVYAVTAGPLTREMILNAAWLYGGPQAILSHDTAAEEWGMRRIDADKPVHVTVPYG KSARCQSATIRRVPARTSGALVRVGGVVHPGVVVHRSRAHRYIGVPSVIPRTSRADTAI DLATAESTARSAYVSLITTVTNARIPLNDVRRRIDERTPHRFKGALSDAVRLLADGVQS TLEYHYAVDVEQAHGLPSARRQSPVRVDGRTLYEDCDYSEVNVPLIVRLDGRWAHSMAE VAFRDRRRDNAAELAGRPRLVYGFEEVVKTPCQVAHEVETVLRRGGWVRTQSGACGTCA PFW" gene complement(12924..15065) /locus_tag="PXH69_RS11095" /old_locus_tag="PXH69_11090" CDS complement(12924..15065) /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]" /GO_process="GO:0006631 - fatty acid metabolic process [Evidence IEA]" /NRPS_PKS="Domain: ECH (13-207). E-value: 2.3e-46. Score: 150.0. Matches aSDomain: nrpspksdomains_PXH69_RS11095_ECH.1" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1023: enoyl-CoA hydratase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943799.1" /locus_tag="PXH69_RS11095" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11090" /product="3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein" /protein_id="WP_030535720.1" /transl_table=11 /translation="MTDQNIINWDQDADGIVVLTINDPNQGANTMNDAYIASMKATVDR LVAEKDSITGAVITSGKKTFFAGGDLKNMIKVGPEQAEEIYNHSVEIKADLRRLETLGK PVVAAINGAALGGGLEIALATHHRIAADVKGVKIGLPEVTLGLLPGGGGVVRTVRMLGL QNALMGVLLQGQQRGPVQAKEVGLIDEVVGSVEELVPAAKAWIKANPEGGVQPWDVKGY KIPGGTPSTPAFAANLPAFPANLRKQLKGAPMPAPRAIMAAAVEGSQVDIDNALLIEAR YFTSLVTGRVAKNMIQAFFFDLQSINGGGSRPAGIEKSTIKKVGVLGAGMMGAGIAYVS AKAGFDVVLKDVTIEAANKGKAYSEGIEAKALSRGKTTQEKSDALLAKITPTADPADFA GVDFVIEAVFESQELKHKVFQEIEDIVDPKALLGSNTSTLPITGLATGVKRQEDFIGIH FFSPVDKMPLVEIIRGEKTSDETLARVFDYVQAIRKTPIVVNDSRGFFTSRVIGTFINE AIGMLAEGVEPATIEQAGMQAGYPAAPLQLSDELNLTLMQKIRKESADAAKAEGKELPA DPAGEVINTLVEKFDRKGKLGGAGFYDYAEGKRTGLWSGLRENFNSGTSDAPIQDLIDR MLFIEAIETQKCFDENVLITTADANIGSIMGIGFPAWTGGVHQFIVGYEGGTAGFVARA KELAAQYGPRFTPPASLGA" aSDomain complement(14445..15026) /aSDomain="ECH" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11095_ECH.1" /evalue="2.30E-46" /label="PXH69_RS11095_ECH.1" /locus_tag="PXH69_RS11095" /protein_end="207" /protein_start="13" /score="150.0" /tool="antismash" /translation="DGIVVLTINDPNQGANTMNDAYIASMKATVDRLVAEKDSITGAVI TSGKKTFFAGGDLKNMIKVGPEQAEEIYNHSVEIKADLRRLETLGKPVVAAINGAALGG GLEIALATHHRIAADVKGVKIGLPEVTLGLLPGGGGVVRTVRMLGLQNALMGVLLQGQQ RGPVQAKEVGLIDEVVGSVEELVPAAKAWIK" gene complement(15111..16325) /locus_tag="PXH69_RS11100" /old_locus_tag="PXH69_11095" CDS complement(15111..16325) /EC_number="2.3.1.9" /GO_function="GO:0016747 - acyltransferase activity, transferring groups other than amino-acyl groups [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (smcogs) SMCOG1124: acetyl-CoA acetyltransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016695648.1" /locus_tag="PXH69_RS11100" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11095" /product="acetyl-CoA C-acetyltransferase" /protein_id="WP_007731553.1" /sec_met_domain="ketoacyl-synt (E-value: 5.4e-07, bitscore: 23.6, seeds: 77, tool: rule-based-clusters)" /transl_table=11 /translation="MTTEAFIYEAIRTPRGRGKKTGSLHSVKPISLVTGLIQELRVRFP DLDEDRISDLILGVVTPVGDQGMDIARVAVNDAGLPDTVGGVQLNRFCASGLEAVNMAA QKVRSGWDELVIAGGVESMSRVPMGSDGGPWALDPATNYDNYFVPQGVGADLIATIEGF SRDDVDAYAVRSQDLAAKAWTGGYFAKSVVPVKDINGITILDNDEHMRPGTTAENLAGL APAFGVIGEIGGFDAVSLQKYHWVEKINHVHHGGNSSGIVDGAALVLVGSEQAGKDMGL TPRARVVATATSGADSTIMLTGPTPASKKVLAAAGLTVDDIDLFEINEAFASVVLKFQK DLNIPDEKLNVNGGAIAMGHPLGATGAMITGTMVDELERRGGKRALITLCIGGGMGVAT IIERV" misc_feature 16302..16313 /note="TFBS match to AfsR, Pleiotropic regulatory for antibiotic production, confidence: medium, score: 18.76" /tool="antismash" gene complement(16548..18359) /locus_tag="PXH69_RS11105" /old_locus_tag="PXH69_11100" CDS complement(16548..18359) /GO_function="GO:0005507 - copper ion binding [Evidence IEA]" /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731555.1" /locus_tag="PXH69_RS11105" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11100" /product="multicopper oxidase domain-containing protein" /protein_id="WP_275231748.1" /transl_table=11 /translation="MGIGVSRRSVLKGSVVGTAAVALGAKAGAAPAGSVDIESPLIFHS PEFEPFCDELHSLSTLSGNEITLTAQVGQHAFHRDFPSSPALSYRSGEIGGGYLGPTVE AHSGEPIMLTFENDLTGHPLAADMDMTLHGMQADFRANPPTSLHLHGGVTSPESDGHPE LLVMPGQAAMHHFLHGQEAAHLWYHDHAMGITRLNVYAGLIGNYLIRDEFDTGELGNPL GLPAEEFEIPLILQEKIFTPTGAQNGRSTILIPEGSWEGGAVGDVGLVNGKVWPELSVA RGLYRLRIVNASSASVWNLHFSNMMTFWVIGNDAGMLDAPVAVNAFRCAPGERYDLLVD FTGLSEGSTVELRNDEAPPLPAAVIGEVTMPLFCRFRGDARRGFTGGVPSQLRGGRRQR DVLAPLEQPTVIRTVTVSQQLELRNPPAQMTLNNLTFSTTDVERPRQGTVEQWNIVNTT PDPHPIHLHLVNFRILGRTPMRTLEYLIRHPQPVIGNKWTPSPDGFEAGPMIAPAPWEA GMKDTVRVDGGTVTRIIVRFPTADELGFDPDAMFDRLPSGVMTGSGMTGGGRHDMADSG RLQGYVWHCHLLDHEDHDMMLPYRIVP" gene complement(18448..20004) /locus_tag="PXH69_RS11110" /old_locus_tag="PXH69_11105" CDS complement(18448..20004) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943824.1" /locus_tag="PXH69_RS11110" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11105" /product="hypothetical protein" /protein_id="WP_275231749.1" /transl_table=11 /translation="MSNAFAIEWQETGKPVVVGDIPPSVDVSLSHDGSKSLSSAGDWPQ GCDIEPIRSRTAVQWKALLGSARIPLLDELIAGGESLDRAGTRLWAAAEAIRKAAGQMS VSLAMGAREDDAVTFRGGAEGSVVVLTFPALLTDNEERILAFVTHEEDAEEPAQDPAPQ FDSGPLSAKSLAQFDPMAYGSDVHVVARSGYPAVSIRFPVGFRDACNVGGSVGFASFAL WLGALRERGTGPISKQIVEDMATGRWGMVTNNSEVFIDANLYTDDIVEGTIWITELTGP DRATTNLHVEWSRVDGETRTHIGWSAMQTTWVEILSHGVVAARPMPQYFHDFIEPMTIP TGTKNIAVPTEPKNVDRGSVIRSAPMVPRNPYLLESEVFSTTLQDGNVVGNIYFGNYYI WQSRVRDKFLVRSQREAMAARGALGELRCVHTRVEHLREVMPFDDVLVTMSLSALYERG IDLEFEYFKVNEDGSREKLAIARHRTVWTMPGAPGELEISPPSKLPQSLIDSVLEAIDG K" gene complement(20001..26111) /locus_tag="PXH69_RS11115" /old_locus_tag="PXH69_11110" CDS complement(20001..26111) /NRPS_PKS="Domain: PKS_KS(Enediyne-KS) (9-468). E-value: 3.6e-90. Score: 294.8. Matches aSDomain: nrpspksdomains_PXH69_RS11115_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (592-889). E-value: 5.5e-63. Score: 205.0. Matches aSDomain: nrpspksdomains_PXH69_RS11115_PKS_AT.1" /NRPS_PKS="Domain: PP-binding (1042-1108). E-value: 1e-08. Score: 27.3. Matches aSDomain: nrpspksdomains_PXH69_RS11115_PP-binding.1" /NRPS_PKS="Domain: PP-binding (1132-1199). E-value: 2.6e-07. Score: 22.9. Matches aSDomain: nrpspksdomains_PXH69_RS11115_PP-binding.2" /NRPS_PKS="Domain: PKS_KR (1436-1617). E-value: 1.8e-36. Score: 117.7. Matches aSDomain: nrpspksdomains_PXH69_RS11115_PKS_KR.1" /NRPS_PKS="Domain: PKS_DH (1690-1791). E-value: 3.8e-10. Score: 32.3. Matches aSDomain: nrpspksdomains_PXH69_RS11115_PKS_DH.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T1PKS: ene_KS" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731558.1" /locus_tag="PXH69_RS11115" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11110" /product="type I polyketide synthase" /protein_id="WP_076948710.1" /sec_met_domain="ketoacyl-synt (E-value: 2.1e-54, bitscore: 178.9, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="ene_KS (E-value: 6.6e-171, bitscore: 563.0, seeds: 19, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 2.7e-62, bitscore: 205.0, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 2.1e-07, bitscore: 25.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTEDSTNPAIAIVGMSMWSPGAHDLQGFWENVLARRMQFRKFPES RMSLDDYWSASPDDVDKTYADRGAFMDGFEFDWVGRRIPERTFKSTDLTHWLALETALG ALTDAGYSRGSVPTGRSAAIVGNSLTGEESRMWSMRLRWPYVKRALAVAAEARQLDSSV ADALAETMEEVYKGPLVEPSEDTLAGMLSNTIAGRICNYLDFNGGGYVVDGACASGMLA VATAAEKLASGAADFVLAGGVDVSLDPLELVGFARLGALTRGDMNVYDASRSGFIPGEG CGFVALKRLEDARADGDYVYATIRGWGISTDGKGGITKPRAETQAEMIRRAYSRAGFAA SEVAFVEGHGTGTPVGDPVELAGVQQAAQTDGPVEARSIGMTSLKSLIGHTKAASGILA LIKATMAVNQRILPPLAGCTDPNPAFGTEAPALFPLVNGEIRDPSEKMRAGAQAMGFGG INCHVAIESADAPSSKLTPSQDVRTMMASYQDTEVFVLSADSAVDLATRARDVADLAVP LSVAELLDFSAKLSRVISPTAPFRAAVVAGRPAQLAERMRQLAVICENSAPASGQVKVV SNEISISNAVHHDIGFLFPGQGSQQLEMARVLIERFEWARELATQADGWLEGVGAEAIT PRILRNPVKSADAAELAKWKRDLAQTQFTQPAVALASLLWFEYLRRLGVTPSAVAGHSL GELTALYAAGAYDQKTLITLAAAKGAAMAVSGGGNGAMASLTCDRSTAEAIIAETKGYA TVANLNTPTQTVVSGTKDAVDDVVAIAKTRGVSAQALAVSNAFHSEMMNEAERELKSTV PVDEQVDSLTCPVYSCVEGKRVQTPLALRELVTKQVVSPVDWVKTVSGISQDVDLLVEV GPGRVLTGLTKAINGTDGVRCFPVASKSGRDEDFNVALAAMYVHGAQVRWNELFDGRFV REFVPADQKVFIENLAEAKLTVTSAPEPLALGTSGGDPAAALADYLSRRGTFLVDVIRA DVGSGATSPSSPSAPTSRAVTNGHESVAAKAPSPVSAPVVEEPADAGAGSVESELIRIL ADTTGFPAESITTDLRLLDDMNLDSISAAEAISKVAHQFEVVDLDPAELANATIGEAAS LILAASPNPGSAVPAASSVQSDVSRILLEVIAEDTGFPVESLDVDLHLLDDLNMDSIKA ADAIATVATRLGVQGDLDPAELVNVSLGELIEVLDRSAKEKSGQQQPVARALPVKAKGL SADSFTWVRDYTLEKVRSETALHGVRDLTDTTFVVIGDDAGLVGRLESELRGRGAQVDI RTFSDGAPANAQHVVAVMPRVTDDSVTEIGLRRGIEHMHKMVPAQQSGGARTTLAVIQF TDVELGNPAPVPSAAAFAASVHHERPELDVRVIGFDGSTADAVVATTVVSELDSVAPYV FATYDTEMGRTALQPRVLASSDYTVRESGLGSSDVVVVTGGAKGIMAQCALALGRKTGA ELVLIGSSQRQAGDEIASTLADFTSAGLSAHYYRCNVTDAAAVAGVVAQIEVEVGPITG FVHGAGANVPRRFERVDSAAAFKEVAPKVLGAANFVEALADRDLKLFVGFSSIIGFTGM PGNSWYAYGNELLDEMVMRYAAGHPKTRTFSLAYSVWGETGMGARMGSVNHLAKMGVMP ISTAAGVDHFLRLVDSGPEASRIVVTSRLGGLDTWAPAAPALPAVSRYIDQVVTFEPQV ELVTRTTLSTSADPFVLDHVWKGSALLPTVFGLEAMSQAAAYVTGRVTLGRVRIDDIKL DRPIVVDTVEGTRVEIKASVVEQDRDAAGTRVHVTIGTERTGYGRPHFSADFIFGLDET LPEFEKELPRPVLDIDPLDDLYSWLLFQEGDFRRLEEISSLDSEHILFSAISRADRKQH LLGDPYFLDSLLQSGQIMVPREICLPVNIARIDMYDGRFEARSFTAYAYDKVQTETHMQ ADVAVVKDGRVVMQLEGYRSQILSHDESRPTAEEIADPTARDAQIILDKLAQHSRALGV KSPRVVVAHTPGIHELTKSERHEQEKPIAEAAVNIHLDEDVVIK" aSDomain complement(20739..21041) /aSDomain="PKS_DH" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11115_PKS_DH.1" /evalue="3.80E-10" /label="PXH69_RS11115_PKS_DH.1" /locus_tag="PXH69_RS11115" /protein_end="1791" /protein_start="1690" /score="32.3" /tool="antismash" /translation="VTFEPQVELVTRTTLSTSADPFVLDHVWKGSALLPTVFGLEAMSQ AAAYVTGRVTLGRVRIDDIKLDRPIVVDTVEGTRVEIKASVVEQDRDAAGTRVHVT" aSModule complement(20739..21803) /domains="nrpspksdomains_PXH69_RS11115_PKS_KR.1" /domains="nrpspksdomains_PXH69_RS11115_PKS_DH.1" /incomplete /locus_tags="PXH69_RS11115" /tool="antismash" /type="pks" aSDomain complement(21261..21803) /ASF="KR domain putatively catalyzing L-configuration product formation" /ASF="catalytic triad S,Y,N inconclusive" /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11115_PKS_KR.1" /evalue="1.80E-36" /label="PXH69_RS11115_PKS_KR.1" /locus_tag="PXH69_RS11115" /protein_end="1617" /protein_start="1436" /score="117.7" /specificity="KR activity: active" /specificity="KR stereochemistry: (unknown)" /tool="antismash" /translation="VVVVTGGAKGIMAQCALALGRKTGAELVLIGSSQRQAGDEIASTL ADFTSAGLSAHYYRCNVTDAAAVAGVVAQIEVEVGPITGFVHGAGANVPRRFERVDSAA AFKEVAPKVLGAANFVEALADRDLKLFVGFSSIIGFTGMPGNSWYAYGNELLDEMVMRY AAGHPKTRTFSLAYSVWG" CDS_motif complement(21327..21422) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11115_0004" /evalue="1.40E-06" /label="PKSI-KR_m4" /locus_tag="PXH69_RS11115" /protein_end="1595" /protein_start="1563" /score="20.8" /tool="antismash" /translation="LKLFVGFSSIIGFTGMPGNSWYAYGNELLDEM" aSDomain complement(22515..22715) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11115_PP-binding.2" /evalue="2.60E-07" /label="PXH69_RS11115_PP-binding.2" /locus_tag="PXH69_RS11115" /protein_end="1199" /protein_start="1132" /score="22.9" /tool="antismash" /translation="ILLEVIAEDTGFPVESLDVDLHLLDDLNMDSIKAADAIATVATRL GVQGDLDPAELVNVSLGELIEV" aSDomain complement(22788..22985) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11115_PP-binding.1" /evalue="1.00E-08" /label="PXH69_RS11115_PP-binding.1" /locus_tag="PXH69_RS11115" /protein_end="1108" /protein_start="1042" /score="27.3" /tool="antismash" /translation="ELIRILADTTGFPAESITTDLRLLDDMNLDSISAAEAISKVAHQF EVVDLDPAELANATIGEAASL" aSModule complement(22788..26084) /complete /domains="nrpspksdomains_PXH69_RS11115_PKS_KS.1" /domains="nrpspksdomains_PXH69_RS11115_PKS_AT.1" /domains="nrpspksdomains_PXH69_RS11115_PP-binding.1" /locus_tags="PXH69_RS11115" /monomer_pairings="mal -> mal" /tool="antismash" /type="pks" aSDomain complement(23445..24335) /ASF="(Methyl)Malonyl-CoA specificity inconclusive" /ASF="found active site serine: True, scaffold matched GHGE: True" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11115_PKS_AT.1" /evalue="5.50E-63" /label="PXH69_RS11115_PKS_AT.1" /locus_tag="PXH69_RS11115" /protein_end="889" /protein_start="592" /score="205.0" /specificity="substrate consensus: mal" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: mal" /tool="antismash" /translation="LFPGQGSQQLEMARVLIERFEWARELATQADGWLEGVGAEAITPR ILRNPVKSADAAELAKWKRDLAQTQFTQPAVALASLLWFEYLRRLGVTPSAVAGHSLGE LTALYAAGAYDQKTLITLAAAKGAAMAVSGGGNGAMASLTCDRSTAEAIIAETKGYATV ANLNTPTQTVVSGTKDAVDDVVAIAKTRGVSAQALAVSNAFHSEMMNEAERELKSTVPV DEQVDSLTCPVYSCVEGKRVQTPLALRELVTKQVVSPVDWVKTVSGISQDVDLLVEVGP GRVLTGLTKAINGTDG" CDS_motif complement(23946..24065) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11115_0003" /evalue="3.70E-09" /label="PKSI-AT-M_m3" /locus_tag="PXH69_RS11115" /protein_end="722" /protein_start="682" /score="28.5" /tool="antismash" /translation="GVTPSAVAGHSLGELTALYAAGAYDQKTLITLAAAKGAAM" CDS_motif complement(24288..24338) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11115_0002" /evalue="4.20E-05" /label="PKSI-AT-mM_m1" /locus_tag="PXH69_RS11115" /protein_end="608" /protein_start="591" /score="16.1" /tool="antismash" /translation="FLFPGQGSQQLEMARVL" aSDomain complement(24708..26084) /ASF="found active site cysteine: True, scaffold matched GSSS: False" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11115_PKS_KS.1" /domain_subtypes="Enediyne-KS" /evalue="3.60E-90" /label="PXH69_RS11115_PKS_KS.1" /locus_tag="PXH69_RS11115" /protein_end="468" /protein_start="9" /score="294.8" /tool="antismash" /translation="IAIVGMSMWSPGAHDLQGFWENVLARRMQFRKFPESRMSLDDYWS ASPDDVDKTYADRGAFMDGFEFDWVGRRIPERTFKSTDLTHWLALETALGALTDAGYSR GSVPTGRSAAIVGNSLTGEESRMWSMRLRWPYVKRALAVAAEARQLDSSVADALAETME EVYKGPLVEPSEDTLAGMLSNTIAGRICNYLDFNGGGYVVDGACASGMLAVATAAEKLA SGAADFVLAGGVDVSLDPLELVGFARLGALTRGDMNVYDASRSGFIPGEGCGFVALKRL EDARADGDYVYATIRGWGISTDGKGGITKPRAETQAEMIRRAYSRAGFAASEVAFVEGH GTGTPVGDPVELAGVQQAAQTDGPVEARSIGMTSLKSLIGHTKAASGILALIKATMAVN QRILPPLAGCTDPNPAFGTEAPALFPLVNGEIRDPSEKMRAGAQAMGFGGINCHVAIES A" CDS_motif complement(25032..25079) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11115_0001" /evalue="2.40E-03" /label="PKSI-KS_m5" /locus_tag="PXH69_RS11115" /protein_end="360" /protein_start="344" /score="10.5" /tool="antismash" /translation="FVEGHGTGTPVGDPVE" misc_feature complement(26714..26727) /note="TFBS match to PerR, Peroxide regulator, confidence: weak, score: 19.38" /tool="antismash" gene complement(26789..29002) /locus_tag="PXH69_RS11120" /old_locus_tag="PXH69_11115" CDS complement(26789..29002) /EC_number="2.7.7.7" /GO_component="GO:0009360 - DNA polymerase III complex [Evidence IEA]" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_process="GO:0006260 - DNA replication [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731559.1" /locus_tag="PXH69_RS11120" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11115" /product="DNA polymerase III subunit gamma and tau" /protein_id="WP_204855044.1" /transl_table=11 /translation="MALYRKYRPASFAEVVGQEHVTAPLSTALDTGRINHAYLFSGPRG CGKTSSARILARSLNCEQGPTSTPCDVCDSCVSLGPGGTGNLDVTELDAASHGGVDDTR ELRDKAFHAPAASRYRVFIIDEAHMVTAAGFNALLKIVEEPPEHLIFIFATTEPEKVLP TIRSRTHHYPFRLLAPSTMRGLLEKICAQEGVPVEPAVYPLVIKAGGGSPRDSLSVLDQ LLAGAGEEGVTYPRALSLLGVTDVALIDEAVDALSASDGAALFGTVDRVMDAGHDPRRF ALDLLERLRDLILMQAVSDASERGLVDAPEAELVTMREQIQRVGPATLTRFAETVHAGL SEMRGATAPRLLLEVMCARMLLPSASDTESAVLQRLERLEQGIPAAGVAAAPRAAATPA PTVPPLEPEIASKFQRPSQRKAEPEVRPEPAAPAPAAAPPVVEAPVVEPPVAAVPVVET PTVEIVEPPVAEAPVVEAPVAEAPIVEAPVVEPPVTAPVEAEELIGLAEPEPDYEPEPE FDEPAVAEAAPVSAGPTVETLRESWNTLRNKVGERNKVLPAMLSAATVHDVRGHVVVIA HGSPVLGARVTQPHNAAVICEVLAEMFGGTWQVEYQEGAPTAPTVSSATKATEAPSRPA AAPRFSRPSQERAAQQPKAPQPQRGDSDDIPPPEAPDYPEDPGPAPAPEVDYEATPPPA TPEDEDEMFAEAAEPADPTARRDPEDVAKELLKDVLGARRLES" gene 29165..30478 /locus_tag="PXH69_RS11125" /old_locus_tag="PXH69_11120" CDS 29165..30478 /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0072488 - ammonium transmembrane transport [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943791.1" /locus_tag="PXH69_RS11125" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11120" /product="ammonium transporter" /protein_id="WP_003943791.1" /transl_table=11 /translation="MPATIDAGATAWLLVSTALVLLMTPGLALFYGGMVRSTGVLNMIM MSFVSIALVTVAWLFVGYSLVFGDDHGGIIGGLEHIGMAGIDPSTVHGNVPEVLFATFQ LTFAILTAALISGAIADRAKFSAWMIFVPIWSLLVYVPVAHWVWNPQGWLAQMGALDYA GGLVVEIVSGASGLALALVLGQRMGFKAESMRPHNLPFVLLGVGLLWFGWFGFNAGSAL AADGMASQIFLNTLVAGCTGLLGWLFVEQNRDGHPTTFGAASGVVAGLVAITPSCGTVN MFGALVIGLIAGIVCSYAVGWKHKLGYDDSLDVVGVHLVGGIVGSLLIGLLATAVMTGG PEGLFFGGGFAQLGKQFVGVVVVALYAFGVTYGLGKLIDKTFGFRISREDEARGIDVAL HAESAYEHGVLGHGPIGGQNPSPFLQRQREERENRERD" gene complement(30485..30856) /locus_tag="PXH69_RS11130" /old_locus_tag="PXH69_11125" CDS complement(30485..30856) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943892.1" /locus_tag="PXH69_RS11130" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11125" /product="carboxymuconolactone decarboxylase family protein" /protein_id="WP_007731560.1" /transl_table=11 /translation="MTDVRASEAFPVTQAMKDSGGWNPLWDGLSELDPEWTELYMKTAM QPWNSGVLSPQVIQLLCIAVDAASTHMYAPGVRRHIRAALDMGVTSKEILEVLKLTTVV GIHSCNVGVPILMEEIANR" gene complement(30865..32454) /locus_tag="PXH69_RS11135" /old_locus_tag="PXH69_11130" CDS complement(30865..32454) /NRPS_PKS="Domain: AMP-binding (8-432). E-value: 6.4e-115. Score: 375.9. Matches aSDomain: nrpspksdomains_PXH69_RS11135_AMP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009476851.1" /locus_tag="PXH69_RS11135" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11130" /product="long-chain fatty acid--CoA ligase" /protein_id="WP_007731561.1" /sec_met_domain="AMP-binding (E-value: 5e-117, bitscore: 385.1, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MLDLAALLEDSARRYPERDALVLGEARLTYAQFDAYANRIAHLLV SRGVEPGDKVALSCPNVLEFPIVYYGILKAGGVVVPLNILLKGREIAYHLADSEAKLYF CFEGSPELPIAEYAIAGFEQSETCSALIVISAEPGAPSSILGVETLGEALASVSGTETP AAAVVREPTDTAVILYTSGTTGKPKGAELTHCNMVLNALSANRLFESVPSMHERYLLTL PLFHSFGQTVTMNAGICVGATLVLMPRFDATAALEIMEREKISVFAGVPTMYWGLLGVL DEVVKSGVDIETVAQNMRCAISGGAALPVEILTQFRERFGVQILEGYGLSETSPLALFS APESDPRPGSIGVPIWGVEARLVDDSWHTIAGPDEVGELAIRGHNVMKGYFNRPEATAE VMCDGWFRTGDLARVDTDGNYYIVDRAKDMIVRGGFNVYPREIEEVLLTHPAVSLVAVV GVPDTSLGEEVVAFVIREPSEEISESDLVEWTREQMAAYKYPRRIEFVPSLPMTATGKI LKRELNQAFSMV" aSDomain complement(31159..32430) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11135_AMP-binding.1" /evalue="6.40E-115" /label="PXH69_RS11135_AMP-binding.1" /locus_tag="PXH69_RS11135" /protein_end="432" /protein_start="8" /score="375.9" /specificity="substrate consensus: X" /tool="antismash" /translation="EDSARRYPERDALVLGEARLTYAQFDAYANRIAHLLVSRGVEPGD KVALSCPNVLEFPIVYYGILKAGGVVVPLNILLKGREIAYHLADSEAKLYFCFEGSPEL PIAEYAIAGFEQSETCSALIVISAEPGAPSSILGVETLGEALASVSGTETPAAAVVREP TDTAVILYTSGTTGKPKGAELTHCNMVLNALSANRLFESVPSMHERYLLTLPLFHSFGQ TVTMNAGICVGATLVLMPRFDATAALEIMEREKISVFAGVPTMYWGLLGVLDEVVKSGV DIETVAQNMRCAISGGAALPVEILTQFRERFGVQILEGYGLSETSPLALFSAPESDPRP GSIGVPIWGVEARLVDDSWHTIAGPDEVGELAIRGHNVMKGYFNRPEATAEVMCDGWFR TGDLARVDTDGNYYIVDRAKDMIVR" CDS_motif complement(31255..31332) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11135_0004" /evalue="1.10E-09" /label="NRPS-A_a6" /locus_tag="PXH69_RS11135" /protein_end="400" /protein_start="374" /score="30.5" /tool="antismash" /translation="EVGELAIRGHNVMKGYFNRPEATAEV" CDS_motif complement(31525..31557) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11135_0003" /evalue="7.40E+00" /label="NRPS-A_a2" /locus_tag="PXH69_RS11135" /protein_end="310" /protein_start="299" /score="1.0" /tool="antismash" /translation="CAISGGAALPV" CDS_motif complement(31873..31932) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11135_0002" /evalue="1.50E-07" /label="NRPS-A_a3" /locus_tag="PXH69_RS11135" /protein_end="194" /protein_start="174" /score="23.7" /tool="antismash" /translation="AVILYTSGTTGKPKGAELTH" CDS_motif complement(32206..32244) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11135_0001" /evalue="1.70E-03" /label="NRPS-A_a2" /locus_tag="PXH69_RS11135" /protein_end="83" /protein_start="70" /score="12.0" /tool="antismash" /translation="GILKAGGVVVPLN" gene complement(32447..33070) /locus_tag="PXH69_RS11140" /old_locus_tag="PXH69_11135" CDS complement(32447..33070) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746533.1" /locus_tag="PXH69_RS11140" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11135" /product="alpha/beta fold hydrolase" /protein_id="WP_042926504.1" /transl_table=11 /translation="MNESTTVVMVPGLRDHVEDHWQTHLARRLDNVLTVPPLETDKLSR DARVAALNEVLTSVCGPVVLVGHSAGVMTVAHWARAHHREVAGALLVTPADLELPLPES YPSLDDLDRHGWLPIPRQRLPFPSTVAASRNDPLAGYRRVVGLAEGWGSRLLDLGEVGH LNPASGYGYWPRAESLVRELLESVSRAASSHATDSDAQEEHSHA" gene complement(33070..34431) /locus_tag="PXH69_RS11145" /old_locus_tag="PXH69_11140" CDS complement(33070..34431) /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1106: major facilitator transporter" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731563.1" /locus_tag="PXH69_RS11145" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11140" /product="MFS transporter" /protein_id="WP_275231750.1" /transl_table=11 /translation="MGLQAPATPRVDTALGIGGRRKLYPWIVFALAFGLLLSDYMSRQV LSAVFPILKADWDLSDSHLASLSSVVALMVGLLTFPLSLLADRWGRVKSLILMAVLWSV ATLLCAIAQTYEQMLGARFLVGVGEAAYGSVGIAVVLSVFAPRVHAALAGAFMAGGSFG SVIGVAIGGFIAVQFSWRWSFAAMAIFGLILVALFRALVTEKKLTAYAVEAAPDAAGEA VRHDGFRAPVSSLFTNPAVLFAYIGGGLQMFTAAVLLAWLPSFFNRYYDLAPDKAGVTA SVFVLLVGSGMVVCGFITDRFSRDDSARKWTTAIVYCAISLVTLSIGLRLGTGIAQLVL LGIGAFFSAGSSGPTAAMVANLTHHSIRASAMGTLTVANNLLGLALGPFVVGILADHLG LLGALQLSPFVYVVAALALVAGKRAYPAGMRRLATLQNRPEIPGATEVTDVRSS" gene complement(34529..35581) /locus_tag="PXH69_RS11150" /old_locus_tag="PXH69_11145" CDS complement(34529..35581) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005567239.1" /locus_tag="PXH69_RS11150" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11145" /product="3-keto-5-aminohexanoate cleavage protein" /protein_id="WP_003943988.1" /transl_table=11 /translation="MHFHDDSLFPETQDKLVITVAPYGPEWEPDDFAEDLPLSMDEHVQ QAVDCFNAGATVLHIHVRELDGKGSKRLSKFNELLGRLREAVPEMILQVGGSISFAPEG EGADAKWLSDDVRHMLAELEPAPDQVTIAINTSQMNIMELMTDDDIAGTSMQRPELADT YREMTVPAGPEWVAEHLRRLQAAGIQPHFQLSSIPQLETVERLIRRGIYTGPVNLTWVA IGGGFDGPNPYNMMNFVQRVPDGACLTLETLMRSVLPVNTMAIAMGLHARCGNEDTIWG RKGEKMTSVQQIEQLVRIAGELGREVATAKEARDIYRIGETYADTDETLAKLGYAPNRR IGQLGFTQHA" gene complement(35634..36533) /locus_tag="PXH69_RS11155" /old_locus_tag="PXH69_11150" CDS complement(35634..36533) /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /NRPS_PKS="Domain: TauD (19-291). E-value: 1.3e-61. Score: 200.7. Matches aSDomain: nrpspksdomains_PXH69_RS11155_TauD.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) TauD" /gene_functions="biosynthetic-additional (smcogs) SMCOG1121: dioxygenase, TauD/TfdA" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746531.1" /locus_tag="PXH69_RS11155" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11150" /product="TauD/TfdA family dioxygenase" /protein_id="WP_204855045.1" /sec_met_domain="TauD (E-value: 6.2e-61, bitscore: 200.7, seeds: 119, tool: rule-based-clusters)" /transl_table=11 /translation="MTNTATLTENLPSSRNTIRVEKLTCSIGAELSGVDLGEVARDDAL FAEIKALLLEHKVLFFRDQTFSKAEHVELAQRFGELEDHPALGSDPDHPGLVRIYKDLD SPPEHFENAYHCDATWRVNPPMGCVLRCVETPPVGGDTIWVNMALAYENLPARVKEQIK DLRARHSIESTFGARMSIEQRHQLKERFPDAEHPVVRTHPETGEKILFVNSFATHLVNY HTPENVRYGIDYAPGAGNLLTYLASQAQIPEYQVRWRWTENSVAIWDNRSTQHYAVQDY WPAVRKMERAGIIGDAPF" aSDomain complement(35661..36476) /aSDomain="TauD" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11155_TauD.1" /evalue="1.30E-61" /label="PXH69_RS11155_TauD.1" /locus_tag="PXH69_RS11155" /protein_end="291" /protein_start="19" /score="200.7" /tool="antismash" /translation="VEKLTCSIGAELSGVDLGEVARDDALFAEIKALLLEHKVLFFRDQ TFSKAEHVELAQRFGELEDHPALGSDPDHPGLVRIYKDLDSPPEHFENAYHCDATWRVN PPMGCVLRCVETPPVGGDTIWVNMALAYENLPARVKEQIKDLRARHSIESTFGARMSIE QRHQLKERFPDAEHPVVRTHPETGEKILFVNSFATHLVNYHTPENVRYGIDYAPGAGNL LTYLASQAQIPEYQVRWRWTENSVAIWDNRSTQHYAVQDYWPAVRKMERA" misc_feature 36547..36561 /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 18.7" /tool="antismash" gene complement(36564..37538) /locus_tag="PXH69_RS11160" /old_locus_tag="PXH69_11155" CDS complement(36564..37538) /NRPS_PKS="Domain: PKS_ER (13-321). E-value: 3.2e-57. Score: 185.9. Matches aSDomain: nrpspksdomains_PXH69_RS11160_PKS_ER.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_N" /gene_functions="biosynthetic-additional (rule-based-clusters) ADH_zinc_N" /gene_functions="biosynthetic-additional (smcogs) SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005257691.1" /locus_tag="PXH69_RS11160" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11155" /product="quinone oxidoreductase" /protein_id="WP_003943928.1" /sec_met_domain="ADH_N (E-value: 1.9e-10, bitscore: 34.9, seeds: 66, tool: rule-based-clusters)" /sec_met_domain="ADH_zinc_N (E-value: 1.2e-26, bitscore: 87.5, seeds: 86, tool: rule-based-clusters)" /transl_table=11 /translation="MANAIRFHEIGTPSVMRWEEIEVGRPGAGEVRVRHEAVGLNFADT YFRSGLYPAQLPAGMGVEGAGVVEEIGEGVVDFAVGDRVTYTGSPLGAYATERIMASSD LIALPDGIAFDTAAAMTMRGLTAAYLLRRIYPLKAGDTVLLHAAAGGVGLIFTQWAKLL GIKVIGTVSSDEKASVARAHGCDEVVIYTREDVVARVKEITGGVGVPVVYDSIGQSTFD ISLDCLARRGLLVCFGTASGPTPPIQAMQLAVKGSLFLTRPALADYIADPEERAELAGE LFSHVESGRIKIEINQRYPLEDAVRAHHDMESGRSIGSSVFSV" aSDomain complement(36576..37499) /ASF="ER configuration inconclusive" /aSDomain="PKS_ER" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11160_PKS_ER.1" /evalue="3.20E-57" /label="PXH69_RS11160_PKS_ER.1" /locus_tag="PXH69_RS11160" /protein_end="321" /protein_start="13" /score="185.9" /tool="antismash" /translation="SVMRWEEIEVGRPGAGEVRVRHEAVGLNFADTYFRSGLYPAQLPA GMGVEGAGVVEEIGEGVVDFAVGDRVTYTGSPLGAYATERIMASSDLIALPDGIAFDTA AAMTMRGLTAAYLLRRIYPLKAGDTVLLHAAAGGVGLIFTQWAKLLGIKVIGTVSSDEK ASVARAHGCDEVVIYTREDVVARVKEITGGVGVPVVYDSIGQSTFDISLDCLARRGLLV CFGTASGPTPPIQAMQLAVKGSLFLTRPALADYIADPEERAELAGELFSHVESGRIKIE INQRYPLEDAVRAHHDMESGRSIGSSV" CDS_motif complement(37074..37121) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS11160_0001" /evalue="4.30E-06" /label="PKSI-ER_m5" /locus_tag="PXH69_RS11160" /protein_end="155" /protein_start="139" /score="19.3" /tool="antismash" /translation="GDTVLLHAAAGGVGLI" misc_feature 37703..37717 /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: weak, score: 20.46" /tool="antismash" gene 37739..38743 /locus_tag="PXH69_RS11165" /old_locus_tag="PXH69_11160" CDS 37739..38743 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731570.1" /locus_tag="PXH69_RS11165" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11160" /product="AraC family transcriptional regulator" /protein_id="WP_007731570.1" /transl_table=11 /translation="MKPLARYASLNRYVDLCRTVDVDAVALMRSVGLSPASLANPDQWV PAASIASLLERSAAESGHEDFGLLLAGLRRLSNLGPLSLVIREEPDVRSALDVLMRYEH TYNESLRIRLNEVNGLATLRISLEVGEPVDTRQSVELAVGATLQILRSFLGSRWQPVSV GFTHNAPKDTSTHRRILGETVEFDHEFTGIVFFAADLDAANQLSDELLRPYARQFLDSL PASETSDTLSRTKELIEVLLPTGRCSVEQVARSLGFDRRTLHRHLAESGDTFTAVLNSV RSSLAERFVSNPRYSLTEVAVHLGFSTQGSFSRWFRTQFSMSPSAWRTQRSIS" gene complement(38736..39782) /locus_tag="PXH69_RS11170" /old_locus_tag="PXH69_11165" CDS complement(38736..39782) /GO_component="GO:0016020 - membrane [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007731571.1" /locus_tag="PXH69_RS11170" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11165" /product="putative sulfate exporter family transporter" /protein_id="WP_275231751.1" /transl_table=11 /translation="MNRDVKSVAEKPAVAPSSEVRRWSSVAALVPGVALCALGATVALI AGQFTSAVSPLLIAIVAGAVLANTVSLPAKFQPGLAFSAKRLLRVGIALLGLQLMFSDI VGLGWGVIAVVVAIVFLGIAGTMYAGKLLGLSWSQRILIACGFSICGAAAVAAADGVVN AREEELLTAVALVVIFGTLMIPTIPLLANAFGMNEVGAGMWAGGSIHEVAQVVAAGSAL GATALGVATVVKLARVLMLAPVMAFLSIRQRRMVDSTATKRPPLVPFFVVAFIGCTGLR STGILPDELLGLVKTVQTALLAAAMFALGLGVRLSVIRGVGARPFVLAAISTVWVATIA YVGVVLVS" gene 39884..40792 /locus_tag="PXH69_RS11175" /old_locus_tag="PXH69_11170" CDS 39884..40792 /GO_function="GO:0001216 - DNA-binding transcription activator activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1014: LysR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746527.1" /locus_tag="PXH69_RS11175" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11170" /product="LysR family transcriptional regulator" /protein_id="WP_275231752.1" /transl_table=11 /translation="MTRRWPDLTTLELLIGIDDHGSLSAASRSANIAQPNASRAVKALE RQLGMPLIHRRSTGAALTPQGTVIVHWARRVLANSRQLLDVAEGMRTERSAELTVCASM TVAEHLIPAWLGIFRSLHPGVTVHLQVYNSTRVLEAVEVGMCDLGFVESPTVPKSLSSV TVARDSLVVVVHPDHPWARRRKPLTVAELAATPLLVREPGSGTRTTLDLALHEYERGAP LLELGSSAAIRTSVLGGVGPAVLSTLAVEDQVKQGELRVVAVEGLELDRSLRAVWRPPR QLEGPSGDLMKVVRASGSRKS" misc_feature complement(39926..39940) /note="TFBS match to MexT, Global virulence regulator, confidence: medium, score: 18.58" /tool="antismash" gene complement(40800..41381) /locus_tag="PXH69_RS11180" /old_locus_tag="PXH69_11175" CDS complement(40800..41381) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943868.1" /locus_tag="PXH69_RS11180" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11175" /product="HhH-GPD-type base excision DNA repair protein" /protein_id="WP_003943868.1" /transl_table=11 /translation="MALQLNLVGDPEADALLAEDPLALLIGMLLDQQVPMETAFLGPKK LADRLSGIDVRRIADMDTDEFIAVCAEPPAVHRFPKSMGERIQLMCQFIVENYDGDTAA IWTSGNPDGKEVLKRLKALPGYGDQKARIFLALLGKQIGVEPKGWRQAAGDYGLEGSRR SIADVVDEQSLLEVREFKKAAKAAAKADKK" gene complement(41400..42755) /locus_tag="PXH69_RS11185" /old_locus_tag="PXH69_11180" CDS complement(41400..42755) /GO_function="GO:0016758 - hexosyltransferase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003943820.1" /locus_tag="PXH69_RS11185" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11180" /product="glycosyltransferase 87 family protein" /protein_id="WP_064073546.1" /transl_table=11 /translation="MTGAINASDGPSFEAHTAKSESVIEADIPRRTLRVGVLGFSVLGV LAVASVLMVLFAVPMNTRYWGIFENFLDLDVYRHGGSVVVQGLPLYDGPVLDGMMFTYT PFAALLFTVWAVLSFKQAIVVWTGLNIAALFAVILLCWKYLGYRLDVKAYAVSALATTI FLFMEPIRTTLWLGQINIFLLLLIVWDLGRDEKSRLRGIGAGIAAGVKLTPAFFWAYLF ITRQWRALVTAVVTFAATVAIGFVVIYNDAYKYWTGTLVDSERVGPTDAPSNQSVSGLI AQLTHTPTPSRVLVLVFSALAVCLGLGAAWIAHRHGQKLLGLTMTGLTATTVSPFSWGH HWVWFVPLVVLAAHYAMVSKKRWAWVAPFVFLLPVLNWSHTWWDPSVIPGTDRFIGMGL FMFVPPEYLRIPTVGVYLWVFTLAAVSTVVLFGWKKWKIPAPDASAPVTTAA" gene complement(42854..44146) /locus_tag="PXH69_RS11190" /old_locus_tag="PXH69_11185" CDS complement(42854..44146) /GO_function="GO:0030170 - pyridoxal phosphate binding [Evidence IEA]" /GO_process="GO:0009058 - biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_1_2 (65-412). E-value: 8.1e-10. Score: 30.3. Matches aSDomain: nrpspksdomains_PXH69_RS11190_Aminotran_1_2.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019: aminotransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746524.1" /locus_tag="PXH69_RS11190" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_11185" /product="aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme" /protein_id="WP_003943985.1" /sec_met_domain="Aminotran_1_2 (E-value: 3.7e-09, bitscore: 30.4, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MPIQTQIGLMSHEELTSEHESQSAKYTQLQAQKLALDLTRGKPSP EQLDLSAELLTLPGDGDFRDGSGTDCRNYGGLTGLPELRAIFGELLGIPVANLLAGNNA SLEIMHDNVVFSLLHGTPDSARPWAQEEKIKFLCPAPGYDRHFAITESLGIEMIAVPMN HDGPDVVKIAELVASDPQIKGMWAVPVYANPTGAVYSEEIVRTLASMPTAAPDFRLYWD NAYAVHPLVGETAPSYDILSMAAEAGHPNRPLVFASTSKITFAGAGVSFFGSSAENLAW YQKFLGKKSIGPDKVNQLRHLRFFGNADGVRAHMEKHRAFLAPKFELVLRILEDRLGAS KVASWTEPKGGYFISLDVVDGTAKRVIELAKNAGIALTAAGSAFPYSTDPDDRNIRLAP SFPSKAELEVAMDGVATCVLLAATESRLSEI" aSDomain complement(42911..43951) /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS11190_Aminotran_1_2.1" /evalue="8.10E-10" /label="PXH69_RS11190_Aminotran_1_2.1" /locus_tag="PXH69_RS11190" /protein_end="412" /protein_start="65" /score="30.3" /tool="antismash" /translation="GSGTDCRNYGGLTGLPELRAIFGELLGIPVANLLAGNNASLEIMH DNVVFSLLHGTPDSARPWAQEEKIKFLCPAPGYDRHFAITESLGIEMIAVPMNHDGPDV VKIAELVASDPQIKGMWAVPVYANPTGAVYSEEIVRTLASMPTAAPDFRLYWDNAYAVH PLVGETAPSYDILSMAAEAGHPNRPLVFASTSKITFAGAGVSFFGSSAENLAWYQKFLG KKSIGPDKVNQLRHLRFFGNADGVRAHMEKHRAFLAPKFELVLRILEDRLGASKVASWT EPKGGYFISLDVVDGTAKRVIELAKNAGIALTAAGSAFPYSTDPDDRNIRLAPSFPSKA ELEVAMD" misc_feature complement(44185..44200) /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 22.89" /tool="antismash" misc_feature complement(44186..44195) /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: weak, score: 15.59" /tool="antismash" ncRNA complement(44188..44287) /db_xref="RFAM:RF00169" /gene="ffs" /inference="COORDINATES: nucleotide motif:Rfam:14.4:RF00169" /inference="COORDINATES: profile:INFERNAL:1.1.5" /locus_tag="PXH69_RS11195" /ncRNA_class="SRP_RNA" /note="Derived by automated computational analysis using gene prediction method: cmsearch." /old_locus_tag="PXH69_11190" /product="signal recognition particle sRNA small type" gene complement(44188..44287) /gene="ffs" /locus_tag="PXH69_RS11195" /old_locus_tag="PXH69_11190" tRNA 44424..44511 /anticodon=(pos:160412..160414,aa:Ser,seq:gga) /inference="COORDINATES: profile:tRNAscan-SE:2.0.12" /locus_tag="PXH69_RS11200" /note="Derived by automated computational analysis using gene prediction method: tRNAscan-SE." /old_locus_tag="PXH69_11195" /product="tRNA-Ser" gene 44424..44511 /locus_tag="PXH69_RS11200" /old_locus_tag="PXH69_11195" misc_feature 45667..45683 /note="TFBS match to ZuR_variant_2, Zinc-responsive repressor, confidence: weak, score: 19.41" /tool="antismash" ORIGIN 1 cgatcacgga tccgcacgcc aactgccatt cactgcggcc ggagttcttg gagaactcgg 61 tggcgccgat cccggcgatg gcggcttgcc tcgaaaatcc tcgtgtcatg cgattaccct 121 ttccaccggt tcgagagtca cgtcggccgt cacgtgtgtt ccgcgcgcgt tctgcccgag 181 aactgtcacg gtgagcgccc gaccgtctgc ggcggtgacc ttgccggtga atgtcattgt 241 gtctccgggg aagttcggaa caccaagccg tagtgatgtt ttgacgattc gcgatcccgg 301 gccggaccag tcggtgatgt agcggtcgat gagcccgttg gtggtgttga tgctcatgaa 361 gatgtcggga gttccgcgat cctgggcctt gcccggatcg tgatgcacgt cctcgaaatc 421 ctgagaagag atcgcagtgg cgacgatcag cgttcgatcc aacggcaatt cgaggctggg 481 gaggaccgaa cccacctcgc agtcaatcag tttcgtcatt gcaccgatcc ccgtcgcctc 541 agttgcggca gcatctcgcc gtgagcgtgc tcggagaacg ccacttcgag ttccatgccg 601 aattcgagtt cctcgtgatc gatccccgcg atgtcggcaa ccagtcgcgt gccttcttcg 661 agatcgacga gtccgacggc gagcgggtac tcgaaggcag gatccttcgg gtgatggatg 721 actgtgaagc tgtgcaacgt gcatcgacgc gtggattcga ctgtgtccca actgaacgag 781 cggcattccg ggcaggcggg cgctggcggg tggcgcagtg tcttgcaatc cgcacaccgt 841 tggatttcga ggcgaccctc tttggccgcg gagaagaaga aatcgttgtc atcggtgacg 901 gtgagtctcg gcaccgcggt gttgcgggag ccagtctcgc tcatgcgatt acctcctggg 961 cttcgggctt ggtatctgtc tgggcatctg gtttgaatct gagcagtcga aagcgctctt 1021 cgaccagcgt ctttccgtcc tggtccacgt acttcttgaa cagggtgatg aagcacccgt 1081 gaccgagagc cgtctgtttg aacggtgaga tcgcttcgat ggtgaaatat gcggtgacgt 1141 ggtctccggg actcaactcc gcgaaatact cctgctcgac gttggtcgcg actacggacg 1201 tgtatccggc ctcgtccaac agcccgagta gtcgtgaata ggcgaaatcc tcggaggctc 1261 cgtcggcgcg aagttgttgg acctgccgat agcggcggta gcccgccatc acccaggtcg 1321 aaatcatggc gggcggacag acgacgtctc gacggccggt actgcgggcg gcctctgcgt 1381 cgacgtagat cgggttgcgg tcgtcgtgcg cctcgaccca gttgcggatc atcgcctcgt 1441 tgacggcgta gcgggcgacg cggggtggtt cggcctctgc gccgatgaaa ttcggaaact 1501 gcgtctgcag gctctgcact gaaatcctcc gtgaacgaaa gttgagcaag cgcttgattt 1561 tgaagctagc ataggaatcc ggaagtggaa acacgcgatc tcaccgacga attggttcga 1621 gccggagcta tcgggcagga ttgcgctacg ttcgacgccg gcagcccggc acccccgaaa 1681 ccctgccctg agcaggaccg acaaccagtg gagatttcag tggcatcacc agatcgtcgg 1741 gagaagatcc tggagagctc agccgagctg tttgccagga agggtgtcgc caccacgacc 1801 gttcgcgaga tcggcgacgc cgccggtgtg ttctcgggca gcctctacca ctacttcaag 1861 tcgaagaatg cgatagttgc cgagctcatg cgcggcttca tcaccgacat tcagctccgc 1921 ttcgatcagg tggagaagac ggcaaacgac cccgaggaag tcctgcgcgg cttgatccgc 1981 gagacgctgg tcgtcatcga actacacccg cacccgacgg cgatctacca gaacgatcgg 2041 gcttatcttc gcgacaacga tctcctgcaa tccgtcgacg ggccttcccg ccaagtccgc 2101 gagcattgga tgaaagcgat tgccgaaggc gtcgatcagg gaatcttccg caaagacgtg 2161 gcaccggaaa ttttctatcg atcggtacga gacaccttgt ggtcgacaac gcattggccg 2221 gatcgccaga agtacaccac cgacgagttc gcggatctga tgatcacgct cttcctctcg 2281 ggattcaggg tcgcctgacc agatccggca aatccagatg tttcggggtt cgtccctgcg 2341 gcaacaggat cgacaccgcg aacacgacca ccgcgcagcc cgcgcacacc aggtaggcga 2401 cggagaatcc ggtccacgac gtggaatgtt ccgaaccgct gatcacgaat gcagcgagaa 2461 tggttgccac cgtcgcactg cagatcgtgc ttccggacgt ccgcagaagt gagttcaccc 2521 cattggcagc cgccagtcgc tgacgaggta cggcaaccag aatcagcagc gagagcgtgc 2581 tgtacacgat ggcagtcccg accgctgtga tacccagtgc tgcaaccact ccccacagcg 2641 gcttaccggc aacggcgtga atcccgtacc cgccggcgag gaacacggca ccggtcaaca 2701 tcgcggtccg tgaaccgaag cggtcggtga tacgcacggc aaccggtgag aacagcacca 2761 tcgcgatact cgccggaatc tggcagagcg ctgccgcgat gatcgacagg ccgtacccgg 2821 cacccggccc cttcatcccc tgcagcagtt gtgtcgtgat cagcgtgttc ccgaaaaacg 2881 cgaacccgac cagcagagcc gccagatgcg ggatcaacac tgcacgtttc acgagagcac 2941 ggacgtcgac cagcggattg acgttgcgcc gctgttgaat tacccagagc gtgaacagca 3001 ccgccgacgc ggccagcatg gagatcaccg ctccactggt ccacccccaa ctcgacccct 3061 gagtgatcgg cacaagcaga gcaatcatcg cggcgctcag accaaccgcc ccgacgccgt 3121 cgaatcttcc cgacggattc ggctcggact ctcgaatgaa cagcaccgca gcaagagtca 3181 cggacagccc gatggcggtg gttacccaga acaggacgtg ccaattcgag tactgcgcga 3241 tcatcgcgga aaacggtatg cccaaagcgg ttccgacacc gagcgtcgaa ctcatcatgg 3301 ccactgcgcc gttgaccttg ttccgtggca attcgtctcg cagcatggag attccgatgg 3361 ggatgactgc cgacccggcc ccctgcaacg ctctcgcgaa gatgagtaca gcgatgtccg 3421 acgacagcgc acacaacatc gagccgagag tcatcatcga gaaagcaacc agaagcatct 3481 tcttcttgcc gaacatgtcg gcgagtcgac cgaagatggg agtgacgaca gcgccgacca 3541 gcagcgtgac ggtcaccagc caggacacgg ccgtgcgtcc agcgccggtg aagtgcggca 3601 actccggcag cagtggaacg atgaccgtct gcagaacagc ctggaacact gcggcggcga 3661 caacgatggg gaacaggaag cgggagcgcg gctgcgcgag tcccgcgtcg gaggtggtga 3721 ctgcaggcgt gcccggcgga cggtcgagcg tcgtcacccc acaccgcctg ttctcactag 3781 gtaaatatcc gttcacctac attaggtgaa cgaatattta cctagcaaga attgtgacgc 3841 cgctcacccg tcgagcagct tttgcaccag cggtgcgtac agcgcaacca cctcgtcctg 3901 ggtgccggtg gcatggccgg ccatcatccg tcggcgcatg atcgccactc cgaccaccat 3961 cgacatcgcc agttccgcgc gcaatctcgc gtcggggccg gacaggcgag cggcgagggt 4021 gtcgatcatc tgcgtcgaat agttctcgcg cagcttgcgg ttgctctctt cactgacgcc 4081 gctcatgaac aacaagctca tggacagcgg cttgtacgac tccaacggct tggtgaacag 4141 cgagaccatg cgctcgccga gcgagtcgtt cggggcatcg aagaccgtga ccgccgctgc 4201 ccggaagtcg accaactcgt cgtacaactg ctctttggaa ccgaagtact tgatgatcag 4261 cggtgcgctg acgcctgcgt cttcggcgat gtccttgagc gtgatttcgc ggtagggccg 4321 agtcgcgaat gctttcccgg ccgacgcgat gatctgcgca cgcgtctgct cggacgtacg 4381 acgcacctgc tgaccttgct ccgtgccgct catcaggcgt tccgcgacaa ttcacgacgg 4441 ccggacaatg cccgacccag cgtcaactcg tctgcgaatt cgagatcgcc acccatcgga 4501 agacccgaag ccaaccgaga caccgtcagc cccggaatgt ctcgcatcat gcgaacgaga 4561 taggtagctg tcgcctcacc ctccgtgttg gggtcggtgg cgatgatgac ctcggacacg 4621 tcgacgccgt cctcctgatt tgcgatgcga gccaacaact cccggatacg caactggtca 4681 ggcccgatcc ccgagagcgg attgagcgca ccgccgagca cgtgataacg acccttgaac 4741 tcacgggtgc gctcgacggc ctggacgtcc ttcggttcct ccacgacgca gatcaccgtg 4801 cgatcgcgac gtgcgtcggc gcagatgcgg cacttctcct gatcggagac agttccgcac 4861 accgtgcaga actgaacgcc gtcacggatg cgctgcaatg catttttcaa acggtcgatc 4921 tcgggaggct ccacggagag caggtgaaaa gcgatgcgtt gagcgctctt cggcccgact 4981 ccgggaagct tcccgagttc gtcgatcaga tcctgaaccg gaccttcgta cacgcgttct 5041 cgtttctaga agccggggag accgggaagg cctccgccga gtccgccggc caacgggccg 5101 agcttctcag cagcgacttc ctgtgcctta cgcgaagcgt cctcgatcgc gccgatcacc 5161 agatcctgca gcgtctcgac atcttcgggg tcgacgacct tgggatcgat ctgcagaccg 5221 acaacctcgc cggtgccctt gaccgtggcg acaaccagtc cgccaccggc ctgaccggtc 5281 acttcggcct gagccatttc ctgctgcgcc gccatcaatt gctgctgcat ctgctgagcc 5341 tgagccaaca gagcagacat gtcgggtgct ccacctggtt gcacgagcgg tcctttctac 5401 agagttatcc ccaccagcgt agtcggtgcg cgctaccgtg agcgggtgcg ccggaaccag 5461 tcagacaccg taaaaccgtc aagagggtca aacatggcat cacgtgtgtt ccgctccact 5521 gccctgatcg ccgtggtcgg ggccgggctt ctgagcgctg cgtgcacgat tccgaccgag 5581 actgccgagg ccacgacttc ggtcgaggtg tctccgctga gcactgtcgc cgctgacgtc 5641 cccgctgcgc tcaccggcaa ggtcgtcttc ctcgatcccg ggcacagcgg ggcgaacgac 5701 gacagcatca acacccaggt ccccacgggc cgcggcggca ccaagaactg ccagaccacc 5761 ggcaccaaca ccgatgccgg gttccccgag cacaccttca actgggaagt cgcgagcctg 5821 gtcaagagcg aactcgaagg ccaaggcgcc acagtggtcc tgagtcgacc ggacgacatc 5881 agcgtcggat cttgcgtcga cgcacgcgcc gaagctgcca attcctccgg cgccgacgta 5941 gtggtgagca ttcacgcgga cggcgcagca gccggagccg agggcttcca cgtctgctac 6001 tccgcgcccc cgctgaacgc ggtgcaggcc ggcccgtccg tcacctttgc cgaaaccatg 6061 cgcgactcac tcgtcacagc cggactcacc ccgtcgacct acatcggtga cgacgggctg 6121 gcaccacgcg ccgatctgac gggactcaat ctgtcgcagc ggccgtcgat tctggtcgaa 6181 ctcggcaaca tgcgaaatgc cgacgaggca gcgcgcatga cgagcccgga cggtcagcag 6241 gaatatgcgt ccgccgtcac cagcggagtc accgccttcc tcacaacccc ctgacctgtc 6301 ttctgtggag aaattccact tgtccacagg tatgtcggca ccgccgaggt agcccgctca 6361 cctggatacg gttctgccat ggggccgata cttcaggtag atttcgctgc tctgcagcaa 6421 ctttcagctg atctgtctcg aattgcggat cagatctcgg ggatcgattc cgccggcccg 6481 attttcgaag ccgcggcggc cctgaactcg tccgctgtcg cggctgtgtc gactgggaat 6541 gccggcgtca tcgccgacgc gtaccggcac cttgctacgc agttgggact catggcgtcc 6601 ggaaccgctg atgcagcgcg tctgttcgac gctgccgagg ctgaagttgt gtccgaactg 6661 cgcggagcct actgatgcag cccaccgtct ctcagcttcg cgcgtggtca ccggagcaat 6721 tgcgcacgat cgcttccgaa ctgatcgaca tcgaccggca gatcgaagct ctcggcaatg 6781 acgccggacg cagcatcgac ggcgttcgcg aattctggct gggacaagcg tcgagtgcgg 6841 ccgcagtgca gtggtcgggt atctcacttg cctcgtctcg actctcgatt gctgctcgcg 6901 tagtcgcgga tctgtatgcc ggagcgtcca atacgatcgg tgcggcgcga aaatcagttc 6961 tggatctggt cgaggaggcg actctccggc acggcttgac ggtgtcagac agtggagcgg 7021 tatcggcacc tgagacgaag cagccgtgga atctggccga cgccatgcaa gattccgaag 7081 acgccacggc tgcacaggtt tttcagcaga agatctccac tgcattgacg gcactcgacg 7141 acgaagacaa tcgggccgcg actgctctgg gtgaggcatt ccgggagatc ggatcactcc 7201 ttggcaatca gcctgatcgt ctcgaccgca ctgtcgtcga catcatcgac gggaggtcga 7261 cactccccgg gacaccagcg gagctacacc gcctctggga atcgctcacg cccaacgaga 7321 aagacgcgtt ggcgaggtgg gatccgtcca tcggtagccg ggacggcctt cccgctctcg 7381 accgggacta ctacaaccgg cggtatctct ctgcgctcga gcagttgccg gatcgaacgg 7441 tcgctgccgg atacacggcc gtgcgcggcg aacttcgacc ggacacgttc cttctctcgg 7501 tcacggatgg gcatgccgtc gtggcagtcg gtaatcccga tgccgccggc aacgtcgcaa 7561 cactggttcc cggaaccggc tccgggctgt cgggcgtcgg cggagacctg caacgaacca 7621 aggccatgta cgacgcggcg gtcagggcgg cgccaacgga agccacatca gtgatcctgt 7681 ggtccggata cgacgctccc ccaggcattc ccgacgcagc ctcggatcgg tacgccacct 7741 ccgcagcgcc gaggctcgac agcttccagg acgggttacg aacctcgcat gacggtccgc 7801 cttcgcacaa cgtggtgatc ggtcattcct acggcagcac cgtcatcggt gctgcgacta 7861 cccgtggcgc ttctctcgac gtcgacgaac tggttcttgt cgcaagcccc ggcgtcgatg 7921 ccgagcgcgt gaacgaactg agcctggacg gcgtcgactc ggacgaggtg gcgcgccatg 7981 ttcattcgac gacggccttc tgggatccgg tccaattgat ccccacgatc ctcggagtcc 8041 acgggttcga cccgtcggat ccggaattcg gcgcgcaggt attcgccgga tcccccgggg 8101 agcctgggtt cggagttcac agcgattact gggaaagcgg aaaccccgca ctcaccgaat 8161 tggggcggat cattaccggc ccatgaaaga aggcgccgta ccggtgaagg tacgacgcca 8221 tctcggtgat gcaggatcgg ttagacgagt tcgcgcttga ggttgtccag gacctgggcc 8281 tggatgcgct gcagaccctt cggagcgaac gtgcgctcga agaagccgcc gataccggtg 8341 gcaccctgcc actgggtgag cgtcgtcacc gtcgttccgg tgccgttggg ggcaacggtc 8401 caggtggtga cgaggctgga gttcgcgtcc ttctcggtga tgacgttgcc gtcgaccgtc 8461 actgtcgcct tgacgttgcg cgagcgcttt tccgtcgcct tgagcgtcca ctgcgcgacg 8521 gttccgtcac cctggccacc ttcgacgacc ttgtagtcga ggtactgctc ggacaggatt 8581 cgcgggcgaa ccgtctcgta gtccgagagc gccgcgagca ccttgtcggg tgctgctgtg 8641 acgactgtcg aactcattgc attgacctga cccatatgcc ctacgtctcc ttgctcgacc 8701 aacgcggctc gataccgcga atgactaccc gaatccgcac ctcgaactgc gcagatattc 8761 ctttccatac tgcctgctgc gcccgggtat ctcgaccatc tacccattcc gtgtgagctg 8821 gttcaccact cggagcattt accgagttcg attgcaacaa ctcgatcaaa ttcgggcatt 8881 aatacccctc cggatagctt gcacacgcaa ctaccgatag cgtcagggtg tgactctctc 8941 gttcaatggg gtagttcaga agttagatcg aatccggaca aagcaaggcc cgggttccga 9001 tgctgcgcgt gaaatggggt tcgagcagca cagagaaggc gtcgaacgcc tactcgcgtc 9061 ataccgcgcc attcccgccg atgcttctgt acgcctggca aagaagacat ccaatctgtt 9121 ccgcgctcgc gccaagacgt cggcccccgg cctcgacgtc agcggtctgg caggtgtcat 9181 cgccgtcgat gcgcaggcgc gcacagccga cgtcgccggc atgtgcacgt acgaggacct 9241 cgtcgacgcg acgctgccct acgggctggc gcccctggtc gtgcctcaac tcaagaccat 9301 caccctgggc ggtgcggtga ccggcctggg catcgagtcc acctcgttcc gcaacggcct 9361 gccgcacgag tcggtactcg aaatcgacgt actgaccgga agcggcgaga tcatcaccgc 9421 aacaccggac ggcgaacacg ccgaactgtt cttcggtttc cccaattcct acggcaccct 9481 tggctattcg acgcgattga agatcgcact cgaacccgtc aagaagtacg tcgccttgcg 9541 ccacgtgcgc ttcgattcgt tgaagaaact cgaagaaacg atggatcgca tcgtcaccga 9601 gcgcgagtac gacgggatcg ccgtcgacta tctcgacggg gtggtcttca ccgattccga 9661 gagctacctc acactcggcg cgcaaaccga cgaggaaggc ccggtcagcg attacaccga 9721 ccaggacatc ttctaccggt cgatccagca ttcgtcactc acccagccca agacggatcg 9781 cttgaccatt cgcgactacc tgtggcgctg ggacaccgac tggttctggt gctcacgagc 9841 tttcggtgca cagaacccga agatccggcg cttctggccc aagcagtacc tgcgcagcag 9901 cttctactgg aagctgatcg ccctcgacca caagtacgac atcggagatc gcctcgaaaa 9961 gcgcaagggc aagcccccgc gcgaacgcgt cgtccaggac gtcgaggtac ccatcgaacg 10021 aaccgcggac ttcgtctcgt ggttcctcga ggaaatcccg atcgaaccac tgtggttgtg 10081 cccgttgcgt cttcgcgagc caagccctgc cgccgcttct gcatcacggc cgtggcccct 10141 ctaccccctc gaacccaagc gcacctacgt caacatcggc ttctggtctt cggtgccgat 10201 cgttcccggt gagcgcgagg gggcagcaaa tcgactgatc gaagaaaagg tcagcgattt 10261 cgacggacac aaatcgctct actccgactc ctactactcg aaggaagact tcgaggagct 10321 gtactacggc ggcgaccggt acatcggact caaggaacgc tacgacccga aatcccgttt 10381 attggatcta ttctctaagg cggtgcaacg taaatgacca cgttcaaaga ctccaaaagc 10441 caggacaagc tctctattgc cgagattctc gagacgcttt ccgacggcat gctgccgctt 10501 cgattcaccg cgtacgacgg cagcaccgcc ggccccgaag atgccgacta cggactgcac 10561 ctcaagtcga ctcgcggaac cacttatctc gcaacagctc ccggtgacct cggcatggcc 10621 cgcgcgtacg tctccggcga tctcgaagcc gagggcgtcc accccggtga tccgtacgag 10681 atcctgcgca tcatgggtga cgaactccac ctcaagcgcc cgtccgcact gacgctcgcc 10741 agcatcacgc gctccctggg ctgggatctg ttgcggccca tcgccccgcc gccccaggaa 10801 catctccctc gctggcgtcg cgtcgcagaa ggactgcgtc actccaagac tcgtgacgcc 10861 gaagtcatcc atcaccacta cgacgtctcc aacaccttct acgagtacgt cctcggcccg 10921 tccatgacgt acacctgtgc cgcttacgac aatgcggaac agacgctcga agaagcccag 10981 gagaacaagt accgcctggt gttcgagaag ctcggactcc agaagggtga tcgacttctc 11041 gacatcggct gcggctgggg ctcgatggtc cgctacgcgg ccaggcgcgg cgtcaaggtg 11101 atcggcgtga ctctctctcg cgagcaagcg gattgggcac agaaggccat cgaggacgag 11161 ggcctcgccg atctcgccca ggtccgtttc tccgactacc gcgacgtggc cgagaccgga 11221 ttcgacgcag tgtcctccat cggcctgacc gagcacatcg gcgtcggaaa ctacccggcg 11281 tacttcgagt tcctcaaggg caagctgcgt gagggtgggc gtctgctcaa ccactgcatc 11341 acccgtccgg acaaccgaag cagcgccaag gcaggcggat tcatcgaccg gtacgtcttc 11401 cccgacgggg agctcaccgg ttcgggtcgc atcatctccg agatccagaa cgtcggcctc 11461 gaggtgcgtc acgaagagaa ccttcgcgag cattacgcac tgacgctcgc cggatggtgc 11521 cagaatctcg tcgacaactg ggacgcctgc gtcgccgagg tcggcgaagg aaccgcccgc 11581 gtctggggcc tgtacatggc cggctcacga ctcgggttcg agcgcaatgt cgttcagctg 11641 caccaggttc tggccgtgaa gctcggcccc aagggtgagg cgcatgtgcc gcttcgcccg 11701 tggtggaagg cctaggggca aagcccctgc gcgccttttt ggtagtcggc actaccaaaa 11761 aggcgcacag gtgccgcagg cacccgactg cgtcctcacc caacctcccc gccgcaagac 11821 cgtctccacc tcgtgcgcaa cctggcacgg agtcttcacc acctcctcga atccgtagac 11881 caaccgcgga cgacctgcca gctctgccgc attgtcacgg cggcgatcac gaaatgccac 11941 ttctgccatg gaatgcgccc accgaccgtc gagacgcacg atcagcggca cattgacttc 12001 gctgtaatcg cagtcctcgt acagcgtgcg gccgtcgacg cggaccggag actggcgtct 12061 ggccgacggc aacccgtgcg cctgctccac gtcgaccgca tagtggtatt cgagcgttga 12121 ctgcaccccg tctgccagga gtcgtaccgc atcggaaagc gcgcccttga atcgatgtgg 12181 tgttcgttcg tcaatccgac gacgcacatc gttcaacgga attcgcgcat ttgtcaccgt 12241 ggtgatgagt gaaacgtagg cgcttcgcgc tgtggattcg gcggtcgcaa gatcaatcgc 12301 ggtatccgcc cgcgacgttc gaggtatgac tgacggcacg ccgatgtatc ggtgggctcg 12361 ggatcggtgg acgactaccc cggggtgaac cacgccaccc actctgacga gtgcacccga 12421 cgttcgcgct ggaactcggc ggattgtcgc ggactgacag cgagcggact tgccgtaggg 12481 cacggtgaca tggactggct tgtctgcgtc gatgcgacgc attccccatt cctcagctgc 12541 agtgtcgtgg ctcagaatcg cttgcgggcc accataaagc caagcggcgt tcaagatcat 12601 ttctctggtg agcgggccag cggtcactgc atacacgcct tgtagaacgc gctgccattc 12661 gccgcggtcc agaaagttcc gccctcggtt gtatccgaat gacgagagtt gctgttgccg 12721 taccagaccg gattgcgcat cgagaatccg gagaaactcg cttccaccat gagacgtagt 12781 catggcacca agcgtcaggc cgaactccga caggactgac gtgaaattcg ctgtcggagt 12841 tcgtctgtgg ataactcaca agctggggat aaacccctgt gcgccttttt ggtagccgta 12901 actaccaaaa aggcgcacgg gggctatgcc cctagcgaag ccggcggggt gaaccgcggg 12961 ccgtactgcg cagcgagttc ctttgcacga gcgacgaagc cggccgtgcc gccctcgtaa 13021 ccgacgatga actggtgaac gccaccggtc caggccggga atccgatgcc catgatggag 13081 ccgatgttgg cgtccgccgt ggtgatcagg acgttctcgt cgaagcactt ctgcgtctcg 13141 atcgcctcga tgaacagcat gcggtcgatg aggtcctgga tcggggcgtc ggaggttccg 13201 gagttgaagt tctcgcggag tccggaccac aggccggtgc gcttgccctc ggcgtaatcg 13261 tagaagccgg ctccaccgag cttgccctta cgatcgaact tctcgacgag ggtgttgatg 13321 acctcgccgg ccggatctgc cggcagttcc ttgccttcgg ccttggcggc gtcggcagat 13381 tccttgcgga tcttctgcat gagggtgagg ttgagctcat ccgaaagctg aagcggcgca 13441 gccgggtaac cggcctgcat accggcctgc tcgatggtgg cgggctcgac gccctcggcg 13501 agcatgccga tggcctcgtt gatgaaggtt ccgatgacac gcgaggtgaa gaagccacgc 13561 gagtcgttga ccacgatcgg cgtcttgcgg atcgcctgga cgtagtcgaa cacgcgagcc 13621 agagtctcgt cggaggtctt ctcaccgcgg atgatctcca ccagcggcat cttgtcgacg 13681 ggcgagaaga agtggatgcc gatgaagtct tcctgacgct tcacgccggt ggcgagaccc 13741 gtgatgggca gcgtcgaggt gttcgagccc agcagtgcct tgggatcgac gatgtcctcg 13801 atctcctgga acaccttgtg cttgagttcc tggctctcga agactgcttc gatgacgaag 13861 tcgacgccgg cgaaatctgc cgggtcagcc gtcggggtga tcttggcgag gagtgcgtcg 13921 gacttctcct gcgtggtctt gccgcgcgag agcgccttgg cctcaatgcc ttcggagtac 13981 gccttgccct tgtttgcagc ctcgatggtg acgtccttga gcacgacgtc gaagcctgcc 14041 ttggcggaga cgtacgcgat gcccgcgccc atcatgcctg cgccgaggac gccgaccttc 14101 ttgatggtgg acttctcgat gcctgccgga cgtgaaccgc cgccgttgat cgactgcagg 14161 tcgaagaaga aggcctggat catgttcttc gcgacgcggc cggtcaccag cgaggtgaag 14221 tagcgagcct cgatgagcag cgcgttgtcg atgtcgacct gcgagccttc gacggctgcg 14281 gccatgatgg cgcgcggagc cggcatcgga gcgcccttga gctgcttacg caggttcgcg 14341 gggaacgccg gaaggttggc agcgaatgcc ggagtggacg gagttccgcc agggatcttg 14401 tagcccttga catcccacgg ctgaacgccg ccttcggggt tggccttgat ccatgccttc 14461 gcagccggaa ccagttcttc taccgagccg acgacctcgt cgatgaggcc gacttccttg 14521 gcctgaacgg gtccacgctg ctgcccctgg agcaggacgc ccatgagcgc gttctgcagg 14581 ccgagcatcc gcacggtgcg cacgacgccg ccgccgccgg gcagcaggcc gagggtgacc 14641 tcgggcaggc cgatcttgac gcccttgacg tctgccgcga tgcggtggtg ggtcgcgaga 14701 gcgatctcga gaccgccgcc gagtgccgca ccgttgatgg cggcgacgac cggcttgccg 14761 agagtttcga gacgacgcag gtctgccttg atctcgacgc tgtggttgta gatctcctcg 14821 gcctgctcgg ggccgacctt gatcatgttc ttgaggtcgc caccggcgaa gaaggtcttc 14881 ttgccggaag tgatgacggc accggtgatg gagtccttct cggcgaccag acggtcgacg 14941 gtggccttca tcgacgcgat gtacgcgtcg ttcatggtgt ttgcgccctg gttgggatcg 15001 ttgatggtga gcacgacgat gccgtcggcg tcctgatccc agttgatgat gttctgatca 15061 gtcactttgc ttgactcctg gtaagcctcg ttggaaggac ggacgccgcg tcagacgcgc 15121 tcgatgatgg tggcaacgcc cataccgccg ccgatgcaca gggtgatgag ggcgcgcttg 15181 ccgccacgac gctcgagctc gtcgaccatc gttccggtga tcatcgcgcc ggttgcaccg 15241 agcgggtgac ccatggcgat agcgccgccg ttgacgttga gcttctcgtc cgggatgttc 15301 aggtccttct ggaacttcag gacgacggaa gcgaatgcct cgttgatctc gaagaggtcg 15361 atgtcgtcga ctgtcaggcc ggcagctgcc agaaccttct tcgacgccgg cgtcgggccg 15421 gtgagcatga tggtggagtc ggcgccgctg gtggcggtgg cgacgacgcg agcgcgcggc 15481 gtcagaccca tgtccttgcc ggcctgctcg ctaccgacga gcacgagggc agcgccgtcg 15541 acgattcccg agctgttgcc gccgtggtga acgtggttga tcttctcgac ccagtggtac 15601 ttctgcagcg acacggcgtc gaatccgccg atttcaccga tcacaccgaa cgcgggagcc 15661 aagccggcga ggttctctgc cgtggtgccc ggacgcatgt gctcgtcgtt gtcgaggatg 15721 gtgatgccgt tgatgtcctt gaccggcact accgacttgg cgaagtatcc gccggtccac 15781 gccttggcgg cgaggtcctg cgagcgcacg gcgtatgcgt cgacgtcgtc acgcgagaag 15841 ccctcgatgg tggcgatgag gtctgcgccg acgccctgcg gcacgaagta gttgtcgtag 15901 ttggtggcgg ggtcgagtgc ccacggtcca ccgtcggatc ccatcggaac gcgggacatc 15961 gactcgacgc caccggcgat caccagttcg tcccagccgg accgaacctt ctgagcagcc 16021 atgttcacgg cctcgaggcc ggaagcgcaa aaacggttga gctgaacgcc gccgacggtg 16081 tcgggcagtc ccgcatcgtt gactgcaacg cgggcgatgt ccattccctg atcgccaacg 16141 ggggtgacga cgcccaggat gaggtcggag atccggtcct cgtcgaggtc gggaaagcgc 16201 acgcgcagtt cctggatcag acccgtgacc agcgagatcg gcttgaccga gtgcaacgac 16261 ccggtcttct tgccgcggcc tcgcggggta cggatggctt cataaatgaa tgcctctgtg 16321 gtcactgtga ggtgttcctt ccgtgtaatt cgtcgaaccg gtctgcagat cgtccgcgcc 16381 accttcggtg gtggcgcatg gccgaggtac agacctcagc cctttcactg tagaacgtgt 16441 tccaaattca tgggaaggac cgaagcgatc ctgctaggtg accgaggtga tcaggtgcgc 16501 gaacgcctgc ccgcttcggt tcatttcggg tgcgcccccg gaagcactca cggcacgatg 16561 cgatacggca acatcatgtc gtgatcttcg tgatcgagta gatggcaatg ccacacgtat 16621 ccctggagtc gaccagaatc agccatatcg tggcgcccgc cgcccgtcat cccactaccc 16681 gtcatcacac cgctcggaag acgatcgaac atcgcgtcgg gatcgaaacc cagctcatcc 16741 gcggtgggga atcgcacgat gatccgggtg acggtgccgc cgtccaccct gacggtgtcc 16801 ttcatccccg cttcccacgg cgccggcgcg atcatcggcc ccgcctcgaa cccgtcgggc 16861 gacggagtcc acttgttgcc gatcaccggc tgcggatggc ggatcaagta ctccagcgtc 16921 cgcatcggtg ttctgccgag aatccggaaa ttcaccaagt gcaggtgtat cggatgcggg 16981 tccggcgtgg tgttgacgat gttccactgc tcgacggtgc cttgccgcgg cctctcgacg 17041 tccgtggtgc tgaacgtcag gttgttcaac gtcatctgag ccggtggatt ccgcagttcc 17101 agttgctggc tcaccgtcac cgtgcgaatt acagtcggct gctccaacgg ggcgagaacg 17161 tcacgttgcc ggcgcccacc gcgcagttgc gacggaacac caccggtgaa tccgcgcctg 17221 gcgtcaccgc ggaaccggca gaacagcggc atagtcactt caccgatgac agcggcgggt 17281 agcgggggcg cctcgtcgtt gcgaagctcc accgtcgaac cctccgacag tccggtgaaa 17341 tcgacgagga ggtcgtaccg ctcccccggt gcgcagcgga aggcattgac cgcgacgggt 17401 gcgtcgagca ttccggcgtc gttgccgatg acccagaacg tcatcatgtt cgagaagtga 17461 agattccaca cacttgccga cgacgcattg acgatgcgga ggcggtaaag gccccgagcc 17521 acggacagtt ccggccacac cttgccgttg accaagccga cgtcgcccac cgcgccgcct 17581 tcccacgatc cttccgggat caagatggtg gatcggccgt tctgggcgcc tgtcggcgtg 17641 aagatcttct cctgcaggat caacgggatc tcgaattcct cggccggcaa ccccaacgga 17701 tttcccagtt cgccggtgtc gaattcatcc ctgatcagat agttgccgat cagaccggca 17761 tagacgttga gccgggtgat gcccatcgca tgatcgtgat accagaggtg ggcggcttcc 17821 tgaccgtgca aaaagtgatg catcgcagcc tgtcccggca tcaccagcag ctccggatgg 17881 ccgtcgctct caggtgaagt gactcctccg tgcaagtgca acgacgtcgg cgggttagcg 17941 cgaaagtctg cctgcattcc atgcagcgtc atatccatgt ccgctgccaa cggatgtccg 18001 gtcagatcgt tctcgaacgt caacatgatc ggctcgccgg aatgcgcctc gacggtaggg 18061 cccagataac cgccaccgat ctctccgctg cggtacgaca gtgctgggga cgagggaaaa 18121 tcccgatgaa aggcatgttg ccccacttgc gctgtcagtg tgatctcgtt tccggaaagc 18181 gttgacaacg aatgtagttc gtcacagaac ggctcgaact ccggcgaatg aaaaatcaac 18241 ggagactcga tatccacact ccccgccgga gcagcacctg cctttgcacc caaagcaaca 18301 gccgccgtgc cgactaccga ccctttcaga accgatcttc tggaaacccc gatacccata 18361 cattcccctc cccatcgaaa cgggttgcgt tctcccgcaa ggaaaacgca acccgtctct 18421 ccacttcgat ctcggaaaat cccccgccta ctttccgtcg atcgcctcca gcaccgaatc 18481 gatcagcgac tgtggaagtt tcgacggcgg agagatttcc agttctcccg gagcgcccgg 18541 catcgtccag acagttctgt gccgagcgat cgcgagcttc tcccgtgatc cgtcctcatt 18601 gaccttgaag tactcgaact cgaggtcgat ccccctctcg tagagggcag aaagggacat 18661 cgtgaccagg acgtcgtcga acggcatgac ctcgcgcaga tgctcaaccc tggtgtgcac 18721 acaacgaagt tccccgagag cgcctctggc cgccatggcc tcacgctgag aacggaccag 18781 gaacttgtcc cgaaccctcg actgccagat gtaatagttg ccgaagtaga tgttgcccac 18841 gacgtttccg tcctgcaacg tcgtcgagaa cacctcggat tcgagcaggt acggattgcg 18901 cggcaccatc ggagccgagc ggatcacgga accacgatcg acgttcttcg gttcggtggg 18961 aacagcgatg ttcttcgtcc ccgtcggaat cgtcatcggc tcgatgaaat cgtggaagta 19021 ctgcggcatc ggccgtgccg ccaccacacc gtgggagagg atttccaccc acgtcgtctg 19081 catcgcactc cacccgatgt gagtgcgcgt ctcgccgtcg acccgggacc attcgacatg 19141 cagattggtg gttgcccgat ccggaccggt gagttcggtg atccagatcg tcccctcgac 19201 aatgtcgtcg gtgtacaggt tcgcatcgat gaacacctcg gagttgttgg tcaccatgcc 19261 ccaacgaccc gtcgccatgt cctccacgat ctgcttcgag atcggtccgg ttcccctctc 19321 tcgcaaagcg cccaaccaca gcgcgaagct cgcgaacccc actgatccac cgacgttgca 19381 cgcgtcccgg aacccgacgg ggaaccggat cgacaccgcc ggatagccgc tccgggccac 19441 cacatgcacg tcggagccgt aggccatcgg atcgaactgc gcgagagact tcgccgacaa 19501 cggtccggag tcgaactgcg gtgccgggtc ctgcgccggt tcctccgcat cctcctcatg 19561 agtcacaaac gcgagaatcc gctcctcgtt gtccgtcaac agagctggaa aagtcagaac 19621 caccacgctt ccctctgcgc cgccgcggaa ggtcactgcg tcgtcctccc tggcgcccat 19681 cgccagagaa accgacatct gccccgcggc ctttcggatc gcctcggccg ccgcccacag 19741 cctggttccc gcacgatcga gtgattcgcc gcctgcgatc aactcgtcca gcagcggaat 19801 ccgcgccgaa cccagaagcg ccttccactg cacggcggtt cgggagcgaa tcggttcgat 19861 gtcacacccc tgaggccagt cgccggccga actgagtgac ttgctgccgt cgtgcgagag 19921 cgagacatcc acagagggcg gaatatcacc gacgacgacg ggctttccgg tttcctgcca 19981 ttcgatggca aaggcattac tcatttgatc accacatcct catcgagatg aatgttcacg 20041 gccgcctcgg cgatcggttt ctcctgctcg tggcgttccg acttggtcaa ctcgtgaatc 20101 cccggggtat gcgcgaccac aacccgcggg ctcttcactc ccaacgcccg gctgtgttgc 20161 gcgagcttgt cgagaatgat ctgtgcgtcg cgcgcagtcg gatccgcgat ttcctcagcc 20221 gtaggacggc tttcgtcgtg ggagagaatc tgggagcgat atccctcgag ctgcatcacc 20281 actcgtccgt ccttcaccac cgccacgtcg gcttgcatgt gggtctctgt ctgcaccttg 20341 tcgtaggcgt acgcggtgaa cgaacgagcc tcgaatcgtc cgtcgtacat gtcgattcgc 20401 gcaatgttga ccggaaggca gatctcccgc ggaaccatga tctgacccga ttggagcagg 20461 gaatcgagga agtagggatc accgaggagg tgctgcttac ggtcggctcg cgaaatagcg 20521 ctgaagagaa tgtgctcgga atcgaggctc gagatctctt cgagtcggcg gaaatcgccc 20581 tcctggaaca gcaaccacga gtagagatcg tccaacggat cgatgtcgag caccggtcgc 20641 ggcaactcct tctcgaactc cggcagtgtt tcgtccagcc cgaagatgaa gtcggccgag 20701 aaatggggcc gtccgtaccc ggtccgttcg gtgccgatcg tgacatgcac ccgcgttcct 20761 gcagcatcac gatcctgctc cacgacgctt gccttgatct cgactctggt gccctcgacc 20821 gtgtcgacga cgatcggtcg atccagcttg atgtcgtcga tgcggacgcg gcccagagtc 20881 acgcgtccgg tgacataggc cgccgcctgc gacatcgcct cgagcccgaa caccgtcgga 20941 agcagcgccg atcccttcca gacatgatcg aggacaaagg gatccgccga ggtggacaac 21001 gtcgtccggg tcaccagttc tacctgcggc tcgaatgtca ccacttggtc gatgtagcgc 21061 gacaccgccg gcagagccgg tgctgccggc gcccaggtgt cgagaccgcc gagtcgactg 21121 gtcacgacga tacgactcgc ctcgggtccg ctgtcgacca ggcgaaggaa atgatccact 21181 cccgcagccg tggaaatcgg catgacaccc atcttcgcga ggtggttgac actgcccatg 21241 cgggcgccca ttccggtctc tccccacacg ctgtacgcga gcgagaacgt ccgagtcttc 21301 gggtgcccgg cggcataccg catcaccatt tcgtcgagaa gctcgtttcc gtatgcatac 21361 cagctgtttc cgggcatacc tgtgaatccg atgatggagg agaagcccac gaacagcttc 21421 aagtcgcgat cagcgagcgc ttcgacgaag ttggctgcgc ccaggacctt aggtgcaacc 21481 tccttgaaag ccgcagcgct gtcgactctc tcgaaccgcc gcggaacatt cgcccccgcg 21541 ccgtggacaa acccggtgat cggcccaacc tcgacctcga tctgggcgac gacgccggcc 21601 accgccgcag catccgtgac gttgcagcga tagtagtgag cgctcaaacc ggcagacgtg 21661 aagtccgcaa gagtggaagc gatttcgtca cccgcttgtc gctgagagct tccgatcagc 21721 actagttcgg cgcctgtctt tcggccgaga gccagagcgc attgcgccat gatgcctttc 21781 gcgccaccgg tcacgaccac tacatccgaa ctccccaacc cgctctcgcg gacggtgtag 21841 tcgctcgagg cgagaacccg cggttgcagt gccgtgcgtc ccatctcggt gtcgtaagtc 21901 gcgaacacat agggtgcaac cgaatccaac tcggagacga cggtggttgc caccaccgcg 21961 tccgcagtcg agccgtcgaa tcctatgacg cggacatcca gttcggggcg ctcgtgatgc 22021 accgaagcgg caaaagccgc cgcactcggt accggcgccg gattgcccaa ctcgacatcg 22081 gtgaactgaa tcactgccaa tgtggttcgt gcgcctccac tttgctgcgc cggaaccatc 22141 ttgtgcatgt gttcgatccc acggcgcaag ccgatttcgg tgacggaatc atcggtcaca 22201 cgcggcatta cggcaaccac gtgctgtgca ttcgcaggag cgccgtcgga gaatgtgcga 22261 atgtcgacct gagcaccacg ccctcgcagt tcggattcca accttccgac caaaccggcg 22321 tcgtcaccga tgacgacaaa cgtcgtgtcc gtgaggtctc ggactccgtg caacgctgtc 22381 tcgctccgaa ccttttccag ggtgtaatcg cgaacccagg tgaagctgtc ggctgataga 22441 ccctttgcct tcaccggcag cgcccgcgca accggctgct gctgccccga cttctctttc 22501 gcggatcgat cgagcacttc gatgagttca cccaggctga cgttgacgag ttcggccgga 22561 tccagatcac cctgaacacc caatcgcgtt gccacagttg ctatcgcatc ggcagccttg 22621 atcgagtcca tgttcaggtc gtcgagcagg tggagatcca catcgagaga ctccaccgga 22681 aatccggtgt cctccgcgat tacctcgagc agtattcgcg acacgtccga ctgcaccgaa 22741 ctcgctgctg gaacggcaga accgggattc ggtgatgccg caaggatcag cgatgctgct 22801 tctccgatcg tggcattggc caactcggca gggtcgaggt cgacaacctc gaactgatgc 22861 gcaaccttcg aaatagcctc tgccgcactg atcgagtcga gattcatatc atcgagcaga 22921 cgcagatccg tcgtgatcga ctcggcgggg aatcccgtcg tatcggcgag gatcctgatc 22981 agctcacttt ccacggaccc agcgcccgcg tcagccggct cttcgactac cggagccgaa 23041 accggcgaag gagctttcgc tgccacggat tcgtggccgt tggtgactgc ccgcgaagtc 23101 ggagcagatg gagaagacgg agaagtcgct ccactgccta catcagcacg aatcacgtcg 23161 acgaggaagg tcccgcgtcg gctcaggtaa tcggccagcg ccgcagccgg atccccgccg 23221 gacgtaccaa gtgcgagcgg ttcgggagca gaggtaaccg tcagcttcgc ctcggccagg 23281 ttctcgatga acaccttctg atcggcagga acgaattcgc gcacgaaccg gccgtcgaaa 23341 agttcgttcc atcggacctg agcgccgtgg acgtacatcg cggccagtgc gacattgaag 23401 tcctcgtcgc gtccggactt ggacgcaacg gggaagcagc gcacgccgtc ggtcccattg 23461 atcgccttgg tgagcccggt cagcacacgg ccgggtccga cctcgacgag caggtccacg 23521 tcctgcgaga ttccacttac cgtcttgacc cagtcgaccg gtgagacaac ctgtttggtg 23581 accaattcgc gaagtgccag tggcgtctgt acgcgtttcc cttcgacgca ggaatacacg 23641 gggcaagtca gcgaatcgac ttgctcgtca acgggcacag tggacttcag ctcccgctcg 23701 gcctcgttca tcatctcgga gtggaaagca ttcgacacgg caagcgcctg agccgacact 23761 ccgcgcgtct tcgcgatggc aaccacatcg tcgaccgcgt ctttggtgcc cgaaaccacg 23821 gtctgtgtag gcgtattcag attcgcgacg gtcgcgtaac cctttgtttc cgcgatgatc 23881 gcctcagccg tcgatcggtc gcaggtcagg ctcgccatcg cgccgtttcc accaccactg 23941 acagccatgg ccgcaccctt cgccgcagcc aaggtgatca gcgtcttctg gtcgtaagct 24001 cctgccgcgt agagcgcggt caactcgccg agactgtggc cggcgacagc actgggtgtg 24061 acacccaatc ggcggaggta ctcgaaccag agcagcgaag ccaaagcgac ggcaggctgg 24121 gtgaactgcg tctgggcgag atcccgcttc cacttcgcca attccgcagc gtcagcgctc 24181 ttgaccgggt tccgcagaat tcgaggcgtg atcgcctccg ctccaactcc ctccaaccag 24241 ccgtccgcct gggtcgccag ttcgcgtgcc cactcgaagc gctcgatcag cacgcgcgcc 24301 atctcgagtt gttgggatcc ctgtcccggg aacaggaatc cgatgtcatg gtggacggcg 24361 ttcgagatcg agatctcgtt gctcacgacc ttcacctggc cggatgcagg agcggagttc 24421 tcgcagatca cggcaagctg acgcatgcgt tcggccaact gcgcgggacg tccggccacc 24481 actgcagcac ggaagggcgc ggtcggcgag atcacgcgag agagcttcgc cgaaaagtcc 24541 agcagctcgg caacactcaa cggaaccgcc agatctgcaa catcccgcgc tcgggtcgcc 24601 aagtccaccg cggaatctgc agaaagtacg aaaacctcgg tgtcctgata cgacgccatc 24661 atcgtgcgga cgtcttgcga gggtgtcagc ttgctggatg gtgcatcagc cgattcgatc 24721 gcgacgtggc agttgatacc gccgaaaccc atggcttgcg caccggcacg catcttctcg 24781 gacggatctc tgatctcacc gttgacgagt ggaaagagtg ccggtgcttc ggttccgaac 24841 gccgggttcg ggtcggtgca accggcgagc ggcggaagga ttcgttgatt gacggccatg 24901 gtcgccttga tcagcgcaag gatgcccgac gccgccttcg tgtgcccgat caacgacttc 24961 agtgacgtca tgccgatgct acgagcctcg acgggcccgt ccgtctgagc ggcctgctgg 25021 acgccggcca gttcgacggg gtctccgacg ggagtaccag ttccgtgtcc ttcgacgaag 25081 gcaacctcgc tggccgcgaa tcccgctcgc gagtatgcgc gacggatcat ctcggcctga 25141 gtttcggcgc ggggcttggt gattccaccc ttgccatcgg tggagatgcc ccagccgcga 25201 atcgtcgcgt acacgtagtc gccgtccgcc ctggcgtcct cgagtcgttt caaggccacg 25261 aatccgcaac cttcacccgg gatgaatccg cttcggcttg cgtcgtacac gttcatgtcg 25321 ccacgggtca gtgcacccaa acgggcgaat cccaccagtt ccaaaggatc caagctgacg 25381 tcgactcccc ctgccaagac gaagtcggcc gcgccggacg ccagcttttc ggctgcagtc 25441 gccaccgcga gcattccgga cgcgcacgca ccgtccacga cgtacccgcc gccgttgaag 25501 tcgagataat tgcagatccg gccggcaatc gtattcgaca acatgccggc gagagtgtct 25561 tcactcggct ccaccaatgg gcccttgtag acctcttcca tcgtctcggc gagagcatca 25621 gcgacggaac tgtccaactg gcgcgcttcg gctgccacag cgagtgcgcg cttgacataa 25681 ggccaacgca aacgcatcga ccacatccgg gattcttcac cggtgaggga gttgccgacg 25741 attgcggcgc tgcgtccagt gggtaccgat cctcggctgt agcccgcgtc cgtcaaagcc 25801 ccgagtgctg tttccagagc caaccagtgt gtgagatctg tcgacttgaa ggtccgctcc 25861 ggtatccggc gaccgaccca gtcgaattcg aaaccatcca tgaacgcgcc gcgatcggcg 25921 tatgtcttgt cgacgtcgtc agggctcgcg ctccagtagt cgtcgaggga catccgtgac 25981 tccggaaact ttcggaattg catccgacgc gcgaggacgt tctcccaaaa tccttgcaga 26041 tcatgcgcac cgggggacca catgctcatc ccgactatcg caatcgcagg attagttgaa 26101 tcttcagtca tcttacactt cctattttcg tgcgcatcca cgggagactc aatcgaccga 26161 agaataacca cgccctcatc ggtgtgtaaa acgcagattc acctcaaggc ataaacaaat 26221 aacaaaggtc gttcggtgca atgaacgtgt ttcagcaatt tgacagcaat cgagagttag 26281 ctgtaactcg gagttactta tttgcttcgc aaccggtcat gctcctgctt ggacatccgt 26341 accggatccc ggtttcacgg ccgccattta ctcgagatcg gcaaatattc agttgaattt 26401 gcaccgaaat gccgcaatgc cgaatatgtg gccaattcgc cgaatgtccc aaattggtcg 26461 atccccgcaa aacaaacatc cgacaactat caatctgaac attcgtgaca caccgaaatt 26521 taacagcagc actcgaatgc ccatcagaca acgagaactt ccagatattc ttcggcgacc 26581 atcgtccgaa tcgacgtttc gttacaccgg aactgagcga acgaatgtgc cagcaaacca 26641 gccacataca attcagcttt gcgaggccga gccggtgcgc tttcgagacg cgcgcgcaca 26701 aagggaacgg cacttataac aattcgatca cacagtggtg cagctggatt ccgacagctg 26761 tttcacgcac acggaccgac tcggcaactc agctttcgag gcggcgagct ccgaggacgt 26821 ccttgaggag ttcctttgca acatcctcgg gatcacgtct ggcagtcgga tcagcgggct 26881 cagccgcctc cgcaaacatc tcgtcctcgt cctccggcgt tgcaggcgga ggagttgcct 26941 cgtagtcgac ctcaggagca ggcgccggtc cagggtcttc cggatagtcg ggggcctcgg 27001 gcggcggaat gtcgtccgaa tctccgcgct ggggttgtgg ggccttgggc tgctgcgctg 27061 cgcgctcctg actgggccgc gagaagcggg gcgcagcggc agggcggctc ggagcttctg 27121 tcgccttggt tgcgctcgat actgtcggcg ctgtaggcgc accttcttga tactcgactt 27181 gccaagtgcc accgaacatt tcggcaagga cctcgcaaat gaccgccgcg ttgtgcggtt 27241 gcgtcacacg agcacccagg accggtgagc cgtgagcgat gacaacgaca tgtccacgca 27301 cgtcgtgaac cgtcgcagcg gacagcatgg ccggaagaac cttgtttcgt tcaccgacct 27361 tgttgcgcaa ggtgttccac gattcacgga gagtctcgac tgtggggcct gccgagaccg 27421 gcgcagcttc ggcaaccgcc ggctcgtcga actcgggctc gggctcgtag tcgggttccg 27481 gctcggcaag cccgatcagc tcttccgcct cgacaggagc agtaaccggt ggttcaacca 27541 caggagcttc aactattgga gcttcggcaa ccggagcttc aaccaccgga gcttcggcaa 27601 ccggcggttc cacgatctcg acagtgggag tctcgacgac gggaactgcc gctaccggag 27661 gttcgacgac aggagcctcc acaaccggcg gcgccgcagc tggagcaggc gcggctggtt 27721 ccggccgcac ctcaggctcg gccttgcgtt gagagggccg ttggaacttg gaagcaatct 27781 ccggttcgag cggcggcacg gtcggtgccg gcgttgctgc cgcgcgaggg gcagccgcga 27841 ctccggcagc cggaatacct tgttccaggc gctccagccg ctgcaataca gctgactcgg 27901 tgtcggatgc cgacggcagc agcattcgcg cgcacatcac ttcgagcagc agccgcggcg 27961 ccgtcgcccc acgcatttcg ctgagtccgg catggacagt ctcggcgaag cgggtgagcg 28021 tggccgggcc gactcgttga atctgctcac gcatcgtgac cagctccgct tccggagcgt 28081 cgaccaatcc tcgttcgctg gcgtcggaaa cagcctgcat caagatgaga tcacgcaggc 28141 gctcgagaag atcgagcgcg aatcggcgtg gatcgtgacc ggcgtccatc acgcgatcga 28201 cagtgccgaa caacgcggcc ccgtcactgg cagacagggc gtctactgct tcgtcgatga 28261 gcgcgacgtc ggtgactccg agaagagaga gcgcgcgcgg atacgtgaca ccttcttctc 28321 ctgcgcccgc gagcagctga tcgaggacac tcaacgagtc acgaggggaa ccgccgccgg 28381 ccttgatgac cagtggatac accgcaggct cgaccggtac gccctcctgg gcgcagatct 28441 tttccaggag tccgcgcatg gtcgacggcg ccaacaggcg gaacgggtaa tggtgtgtac 28501 gcgaacggat ggtcgggaga accttttccg gttccgtcgt cgcaaagatg aagatgaggt 28561 gttccggcgg ctcttcgacg atcttgagca acgcattgaa acccgccgcc gtcaccatat 28621 gtgcctcgtc gatgatgaag acgcggtagc gagaagcagc gggtgcgtgg aacgccttgt 28681 ctcggagttc tcgggtgtcg tcgacgccac cgtgacttgc ggcgtcgagt tccgtcacat 28741 ccaggttgcc tgtgccgccc gggcccagcg aaacgcacga gtcgcacacg tcgcacggcg 28801 tcgacgtcgg tccctgctca cagttcagcg aacgcgccag gattcgcgcc gacgacgtct 28861 ttccgcagcc gcgcgggccg gaaaacaggt aggcatggtt gatgcgtccg gtgtcgaggg 28921 ccgtgctgag cggtgcggtg acatgctcct gccccaccac ctcggcgaag gacgcgggtc 28981 gatacttccg gtacagggcc acgcgcaaag actaccggcg acccacgaca ggtggtccgg 29041 tgcgggtgca acgccgactt ctcccgaaac atgttcgcaa cacaatcgca gtgcggagga 29101 aaccgcacgc actcatcgtg ggttccgtgc acgcgggctg gtccgcgtgc gtgaggagaa 29161 aactgtgccc gccaccatcg atgccggagc gactgcctgg ttgctcgtca gtactgcact 29221 cgtacttctg atgacgccag gactcgcact gttctacggc ggcatggtcc gctcgacggg 29281 cgtactcaac atgatcatga tgagtttcgt ctccatcgca ctcgtcacgg tcgcgtggtt 29341 gttcgtgggc tacagcctcg tgttcggcga cgatcacggt ggcatcatcg gcggactcga 29401 acacatcggc atggcgggca tcgacccgtc gaccgtgcac gggaatgtcc cggaagtgtt 29461 gttcgcaacc ttccaattga cgttcgcaat ccttactgca gcactcatca gtggtgcgat 29521 cgccgaccgc gcgaagttct ccgcctggat gatcttcgtc cccatctggt ccttgctcgt 29581 ctatgtcccc gttgctcact gggtgtggaa tccgcaggga tggctcgccc agatgggcgc 29641 actcgactac gccggtggcc tcgtggtcga aatcgtgtcc ggagcgtcgg gtctggcatt 29701 ggcactggtc ctcggccagc ggatgggttt caaggccgag tcgatgcgtc cgcacaatct 29761 gccgttcgtc ctgctcggcg tcggcctgct ctggttcggt tggttcggat tcaacgccgg 29821 ctcggccctt gcggccgacg gtatggcctc gcagatcttc ctcaacacac tcgtcgccgg 29881 ttgcaccgga ctactcggct ggctgttcgt cgagcagaat cgtgacggac accccacgac 29941 gttcggcgca gcttcgggcg tcgtcgccgg tctggtcgcg atcaccccgt cgtgcggaac 30001 ggtgaacatg ttcggtgcgc tcgtcatcgg tctgatcgcc ggcatcgtct gctcgtacgc 30061 cgtgggatgg aagcacaagc tcggctacga cgactccctc gacgtcgtcg gcgtgcacct 30121 cgtcggtgga atcgtcggct cgttgctgat cggactcctc gcgacggccg tgatgacggg 30181 cggtccggaa ggtttgttct tcggcggtgg attcgcgcag ttgggcaagc agttcgtcgg 30241 cgtcgtcgtg gtcgcgctct atgccttcgg tgtgacctac ggtctcggaa agctcatcga 30301 caagaccttc ggcttccgca tttcgcgtga agacgaggcc cgcggaatcg acgttgccct 30361 gcacgcggag tcggcctacg agcacggagt cctcggccac ggtccgatcg gcggacagaa 30421 cccgagcccg ttcctccagc gtcagcggga ggaacgggag aaccgcgagc gggactgacc 30481 gccctcagcg gttcgcgatt tcctccatca ggatcggaac gccgacattg caggaatgaa 30541 tcccgacgac ggtggtcagt ttcagcacct cgagaatctc cttcgaggtc actcccatgt 30601 cgagcgcggc gcgaatatgg cgtcgtacgc cgggtgcgta catgtgtgtg ctcgccgcat 30661 cgacggctat gcacagcaac tggatcacct gaggtgacag caccccgctg ttccagggct 30721 gcatcgctgt cttcatgtac agctcggtcc actcgggatc cagctccgaa agtccgtccc 30781 acaacggatt ccagccaccc gaatccttca tggcctgggt cacgggaaaa gcttcacttg 30841 ctcgaacgtc agtcatcgat ctcctcagac catcgaaaat gcttgattca gttcacgttt 30901 gagaatcttt ccggttgccg tcatcggcag cgacggcacg aactcgatgc gacgcggata 30961 tttgtaggcg gccatctgtt cccgcgtcca ttccacgaga tccgattcgg agatctcttc 31021 actcggctct cggatcacga acgcgacaac ttcttcgccg aggctcgtgt ccggcacccc 31081 gacgacggcg acgagtgaga cggctgggtg agtgagcaga acctcttcga tttcgcgtgg 31141 gtagacgttg aatccgcccc gcacgatcat gtccttcgcg cgatcgacga tgtagtaatt 31201 tccgtcggta tcgacccgtg ccaaatcccc ggtgcgaaac catccgtcgc acatgacttc 31261 cgccgtcgcc tctggtcggt tgaaatagcc cttcatgacg ttgtgcccgc gaatggccaa 31321 ctctcccact tcatcggggc cggcgatcgt gtgccaagag tcgtcgacaa gccgcgcttc 31381 gacgccccag atcggcacgc cgatcgaacc gggccggggg tcactctccg gggcactgaa 31441 caaggccagc ggagaggtct cggacaaccc gtacccttcg aggatctgaa caccgaagcg 31501 ttcccggaac tgtgtcaata tttccacggg aagcgctgcg ccacccgaga tcgcgcaccg 31561 catgttctgt gcaacggtct cgatatccac cccggatttc actacctcgt ccagcacgcc 31621 gagcagtccc caatacatgg tcgggacgcc cgcgaagacc gagatctttt cgcgttccat 31681 gatctcgagt gccgcggtcg catcgaagcg cggcatcaac accaaagtgg caccgacgca 31741 gattcccgca ttcatggtca ctgtctggcc gaacgagtgg aacaacggca aagtcaggag 31801 ataacgctca tgcatggacg gaacgctctc gaacaaccgg ttggccgaca gtgcattcaa 31861 gaccatgttg cagtgagtga gttcggcgcc cttgggcttt ccggtcgtgc cgctggtgta 31921 gagaatgacc gcggtgtccg tcggttcacg aacaaccgcg gctgcaggcg tttccgtgcc 31981 ggacacggat gccagtgctt cgcctagagt ctcgactccg aggatcgacg acggtgcacc 32041 cggttcggcg ctgatcacga tcagggccga acaggtctcg ctctgctcga acccggcgat 32101 ggcgtactcg gcgatcggta attcgggact tccctcgaaa cagaagtaca gcttcgcttc 32161 cgaatcagcc aggtgatagg caatttcgcg ccccttgagc aggatgttca gaggaacgac 32221 gacgccaccg gccttgagaa tgccgtagta gacgatcggg aactcgagaa cgttcgggca 32281 ggacaacgcc accttgtcac ctggctcgac accccgcgag acgagcagat gggcgatgcg 32341 attcgcgtac gcgtcgaact gcgcatacgt cagcctcgct tccccgagaa ccagcgcatc 32401 ccgttccggg taccgccggg ccgagtcttc cagcagagca gcaagatcaa gcatgactgt 32461 gttcctcctg cgcatcggaa tccgtggcat gagacgaggc agcacgcgac accgactcga 32521 gcagttcccg caccaacgat tccgcccgcg gccaataccc gtatccggac gccggattga 32581 gatgtccgac ctcacccaga tccagcaacc gactccccca tccttcagcc aaacccacaa 32641 ctcggcgata cccggcgagc ggatcgttcc gactcgccgc gaccgtgctc ggaaacggca 32701 gacgctgacg cggtatcggt agccacccgt gtcggtcgag atcgtcgaga gacggataag 32761 actcgggcag cggaagttcg agatccgccg gcgtgaccag aagtgcgccc gcaacctctc 32821 gatgatgcgc cctcgcccag tgagcaactg tcatgactcc ggcgctgtgc ccgaccagga 32881 ccaccggccc gcagacactt gtcagcacct cgttcaatgc cgcaacccgc gcatcgcgac 32941 tgagcttgtc ggtctcgagg ggaggaaccg tcagaacgtt gtcgagcctg cgcgcgaggt 33001 gagtctgcca atgatcttcg acatgatccc gcagaccggg aaccattact accgtagttg 33061 attcattcat catgagctcc gaacgtctgt tacttcagtg gcgccgggga tctcgggccg 33121 attctgcaac gtcgccagcc gcctcatccc ggcgggatag gcacgcttgc cggctaccaa 33181 cgcgagggcc gcgacgacat agacgaaggg cgaaagctgt agagcgccga gaagacccag 33241 gtgatcggcg aggatgccga caacgaaggg accgagcgcc agcccgagaa ggttgttggc 33301 gacggtgagc gttcccatgg ccgacgctcg aatcgagtga tgggtaaggt tcgcgaccat 33361 cgctgccgtc ggccccgacg aaccggcgga gaagaatgca ccgataccga gcaacacgag 33421 ttgtgctatc cccgtgccca accggagccc gatgctcagc gtcaccaacg agatggcgca 33481 gtagacgatg gcggtggtcc attttcgcgc cgaatcgtcg cggctgaatc tatctgtgat 33541 gaaaccgcag accaccatcc cgcttccgac caggaggacg aacacggaag ccgtgacgcc 33601 ggccttgtcc ggggccaaat cgtagtaacg attgaagaag ctcggcaacc acgccagaag 33661 tacagcggcg gtgaacatct ggagaccacc accgatgtag gcgaataata cggctggatt 33721 ggtgaacagc gaggacaccg gcgcacgaaa accgtcgtgt ctcaccgctt ccccggcggc 33781 atccggcgcg gcctcgacgg cgtaagcggt gagcttcttc tcggtgacga gggcacggaa 33841 gagcgcgacc agaatcagac cgaagatcgc catggcggca aaagaccacc gccaactgaa 33901 ctggactgcg atgaacccac cgattgccac accgatgacc gaaccgaacg atccaccggc 33961 catgaaggca cctgcaagag ctgcgtgcac gcggggcgca aacacactga ggaccacggc 34021 gatacccacg ctgccgtacg ccgcttcacc gacaccgacc aggaaccggg cgcccaacat 34081 ctgttcgtag gtctgagcga ttgcgcacag caacgtcgcg acactccaca acaccgccat 34141 caagatcaag ctcttgacgc ggccccagcg gtccgcgagc agcgacaacg ggaacgtcaa 34201 cagcccgacc atcaatgcca ccacgctgct cagggaggcg aggtgcgaat cggagagatc 34261 ccagtccgct ttcaggatcg ggaagactgc actgagcacc tgcctcgaca tgtagtccga 34321 gagcagaaga ccgaaagcca gggcgaaaac gatccacggg tataactttc gtcgtccgcc 34381 gattccgagc gcggtgtcca cacgtggcgt ggcgggagct tgcagtccca tgactctcct 34441 aggaagtact cgaggtagac ggggggattc gggggtacga accgtcgcgg ttcgtacccc 34501 cggaactgtt gtacgagagg gtgcgaactc aggcgtgctg cgtgaatccc agctggccga 34561 tccggcggtt gggcgcgtaa cccagcttcg ccaacgtctc gtcggtgtcg gcatacgtct 34621 caccgatccg gtagatgtcc cgagcttcct tcgcggtagc cacctcgcgg cccaattcgc 34681 ctgcaatgcg caccaactgc tcgatctgct gcaccgacgt catcttctcg cccttgcggc 34741 cccagatggt gtcctcgttg ccgcagcgag cgtgcaagcc catcgcgatg gccatcgtgt 34801 tcaccggcag gacgctacgc atcagcgttt ccagcgtcag gcacgcaccg tcgggaacac 34861 gctggacgaa gttcatcatg ttgtatgggt tgggtccgtc gaagccgccg ccgattgcga 34921 cccacgtgag gttgaccgga cccgtgtaga tgccgcgtcg gatcaaccgc tccaccgttt 34981 cgagctgcgg aatactggac aactggaaat gcggctggat tccggcggcc tgcaaccggc 35041 gcaggtgctc tgccacccac tccggaccgg cgggcacagt catttcccga tacgtatcgg 35101 ccaattccgg acgctgcatc gacgtacccg cgatgtcgtc gtcggtcatc agttccatga 35161 tgttcatctg gctggtattg atcgcgatcg tcacctgatc gggagccggc tccaattccg 35221 ccagcatgtg acgcacgtcg tcggacaacc acttcgcatc ggcaccttcc ccctccgggg 35281 caaacgaaat cgacccgccg acctgcagaa tcatctcggg aacggcctca cgcaagcgac 35341 cgagaagctc gttgaacttc gacagacgct tcgagccctt gccgtcgagt tcacgcacgt 35401 ggatgtggag aactgtggca ccggcgttga agcagtcgac ggcttgctgg acgtgctcgt 35461 ccatcgacag agggaggtct tctgcaaaat cgtccggctc ccactccggt ccgtagggag 35521 caacggtgat gacaagcttg tcctgggttt cggggaacag tgaatcgtcg tggaaatgca 35581 tagcgtgact ccgatcgagt gaatgaattt atcttcgggg ctgggaagag agatcagaac 35641 ggtgcgtcgc cgatgattcc ggcgcgctcc atctttcgaa ccgcgggcca gtagtcctgc 35701 accgcgtaat gctgtgtcga acggttgtcc cagatcgcga cgctgttttc ggtccaacgc 35761 caccgaacct ggtactcggg aatctgagcc tggctcgcca ggtaagtgag cagattcccg 35821 gcgccggggg cgtaatcgat tccatagcgg acgttctcgg gcgtgtgata gttcacgagg 35881 tgtgtggcga acgaattgac gaagagaatc ttctcgccgg tctccggatg tgttcgtacc 35941 acgggatgtt cggcgtcggg aaagcgttcc ttcagctggt gccgctgttc gatcgacatc 36001 cgagcgccga aggtcgactc gatactgtgc ctggcacgca gatccttgat ctgctccttg 36061 acccgcgccg gcagattttc gtaggcgagt gccatgttca cccaaatcgt gtcgccgccg 36121 acaggaggtg tttccacaca acgcaataca catcccatgg gcgggttaac gcgccaggtg 36181 gcgtcgcagt gatatgcatt ctcgaaatgc tccggcgggc tgtccagatc cttgtagatg 36241 cggaccaggc ccgggtggtc ggggtcgctg cccagagccg gatgatcctc gagttcaccg 36301 aatcgctggg caagttctac gtgctcggct ttggagaagg tctggtcgcg aaagaacaga 36361 accttgtgtt cgagcaacaa tgccttgatt tcggcgaaga gtgcatcatc tcgcgcgacc 36421 tcgccgagat ccaccccgga caactctgcc ccgatcgaac aggtcaattt ctcgacgcgg 36481 atcgtattcc tcgacgaggg aaggttttct gtgagcgttg cggtgttggt catgacaatt 36541 cctctgggaa gtgctgtttc ggttcagacg gagaagacgg aggaaccgat actgcgaccg 36601 gactccatgt cgtggtgcgc acgcaccgca tcttcgaggg ggtatcgctg gttgatctcg 36661 atcttgattc gcccggactc gacgtgtgag aacagttcgc ccgccagttc ggcacgttct 36721 tcgggatccg cgatgtaatc ggcgagagcc ggacgtgtga ggaagagtga tcccttgact 36781 gccaactgca ttgcctgaat cggcggagtc ggtccggacg ccgttccgaa gcacaccagc 36841 agcccccgcc tggcaaggca atcgagagag atgtcgaacg tggattgccc gatactgtcg 36901 tagacaaccg gcacgccgac gcccccggtg atctccttga cacgcgcgac gacgtcctcg 36961 cgggtgtaga tgacgacttc atcgcaaccg tgagctcggg caacgctcgc cttctcgtcg 37021 ctcgacaccg ttccgatcac tttgattccc aacagttttg cccactgggt gaagatcagt 37081 ccaaccccgc ccgccgcagc atgtagcaac acggtgtctc ccgctttcaa cgggtagatg 37141 cgacgcagaa ggtaggcggc agtcagtcct cgcatggtca tggcggccgc ggtgtcgaag 37201 gcgatgccgt cgggtagcgc gatcaggtcg gacgacgcca tgatccgctc ggtggcgtac 37261 gcacccagcg gactgccggt gtaggtcaca cggtccccca ctgcaaaatc gactactccc 37321 tcgccgatct cttcgaccac accggcgccc tcgacgccca tcccggcagg caattgcgca 37381 ggatagaggc cacttcgaaa gtaggtgtcg gcgaagttca accccaccgc ttcatgacga 37441 acccgaacct ctccggcgcc cggtcgtcct acctcgatct cttcccaacg catgacggac 37501 ggtgtgccga tctcgtggaa ccgaatggcg tttgccatca atgctctcca attctgtggg 37561 cgggctcgac tcgattacgg tcgagctgta ttcgtacgca acaacttcca gaagtcggtg 37621 ctcggcttcg tggtcgtgcc gaactgatgt gaacaaaact atgtgagatc cggctcacat 37681 gcttaacttg acgagacaca caacacaaca tttcgggaca tcgagtaaag ggggccctat 37741 gaagccactc gcccgctacg cgtcactgaa ccgatacgtc gacctgtgcc gaacagtgga 37801 tgtggacgct gttgccctca tgagaagtgt cggcctgagc ccggcaagcc tggcgaaccc 37861 cgaccaatgg gtaccggccg cctccatcgc atcgctcctg gagcgatcgg cagcggagtc 37921 cggacacgaa gacttcgggc ttctactcgc cggcctgcgt cgactgtcca atctcggccc 37981 cctcagcttg gtcatcaggg aagaaccaga cgtcaggagc gcactcgacg tgttgatgcg 38041 atacgagcac acgtacaacg agtcattacg cattcgattg aacgaggtca acggactcgc 38101 caccctgcga atctcgctcg aggtcggcga accggtcgac accagacaga gcgtcgaact 38161 cgcagtcggc gcgacactgc agatcctgcg gagtttcctg ggttctcgat ggcaaccggt 38221 cagcgtggga ttcacgcaca atgccccgaa agacacgagc acgcatcggc gaatcctcgg 38281 cgagacggtg gaattcgatc acgagttcac cggtatcgtt ttcttcgccg ccgacctgga 38341 tgcggctaac caactttccg acgagttact ccggccgtac gctcgccagt tcctcgactc 38401 gcttcccgcc tcggaaacct ccgataccct cagccgcacc aaggaattga tcgaagttct 38461 gcttccgacc ggccgctgct ctgtcgagca agtggcacgc agtctcggat tcgaccggcg 38521 gacactgcac cgtcatctcg ccgaatccgg agatacgttc acggccgttc tcaattcggt 38581 tcgaagctcc ctcgcggaac gatttgtctc caaccctcgc tattcgttga ccgaagtggc 38641 tgtgcacctc gggttttcga cgcagggtag tttctcgcgc tggtttcgca ctcagttctc 38701 gatgagcccg agcgcgtggc ggactcagcg ctcgatcagc tgaccagcac gactccgacg 38761 taggcgatcg ttgccaccca cacagtggaa atcgcggcca gcacgaatgg ccgggcgcca 38821 actccacgaa tgacgctcaa ccgcaccccc agcccgagtg cgaacatcgc ggcggccaac 38881 agcgccgtct gcaccgtctt caccagcccc agaagctcat ccggcaagat gcccgtggag 38941 cgcaagcccg tacagccgat gaacgccacg acgaaaaacg gaaccaacgg aggacgcttg 39001 gtggcggtgc tgtcgaccat cctgcgttgc cggatgctca gaaatgccat gaccggcgcc 39061 aacatcaaca cgcgcgcaag tttcaccacg gtcgcgacac ccaacgcggt ggcgccgaga 39121 gcgctgccgg cagccaccac ttgcgccact tcgtggatcg acccaccggc ccacatgcct 39181 gcaccgacct cgttcatacc gaaagcgttg gccaacagtg ggattgtcgg aatcatcaga 39241 gttccgaaga tcaccaccaa cgcaacagcg gtgagcaact cttcctctcg cgcattcacc 39301 acaccgtccg cagcagccac ggcggcagcg ccacagatcg agaagccgca ggcaatcaga 39361 attctctgcg accaactcaa tccgagaagt tttccggcat acatggtccc ggcgataccg 39421 aggaacacaa tcgccaccac aacggcgatc actccccagc ccaaaccgac gatgtcggag 39481 aacatcaatt gcagcccgag cagagcgata cccacccgaa gtagccgttt cgccgagaat 39541 gccaggccag gttggaattt cgccggcaaa gagacggtat tcgccaacac cgcacccgcc 39601 acgatcgcaa tcagcaacgg actcacggcg gaggtgaact gaccggctat cagcgcgacc 39661 gtggccccca aggcgcacaa cgcaactccg ggcaccaatg cagccacact ggaccaccgt 39721 cgtacttctg acgaaggggc gactgcgggt ttctcggcca cggacttcac atcacggttc 39781 actcatccag cgtccttgag ccaccatcgc tccggtaggg cgatttctac catcacggca 39841 tatcaaatcg atatgaacgt gaagttcggt atagcctgtt tgcatgacca gacggtggcc 39901 cgacctcacc actctcgagc tactcatcgg catcgatgat cacggaagtc tcagtgcggc 39961 aagccgttca gcaaacattg cgcagccgaa tgccagccgc gccgtcaaag ccctcgagcg 40021 gcagctcggg atgccactca tacaccgaag gtcgacgggg gcggctttga ctccgcaggg 40081 gaccgtcatc gtccactggg cgcgccgcgt cctcgccaac tcgaggcagc ttctcgacgt 40141 cgccgaaggg atgcggaccg aacgatccgc ggaattgacc gtgtgtgcca gcatgaccgt 40201 cgccgaacat ctgattccgg cctggctcgg tatctttcgg tcactacatc ctggtgtcac 40261 cgtccacctt caggtctaca actcgacccg cgtcctcgag gctgtcgagg tgggaatgtg 40321 cgacctcgga ttcgtcgagt caccgaccgt tccgaagagc ctgtccagcg tcaccgtcgc 40381 gcgtgactcg ctggtcgtgg tcgttcatcc ggatcatcca tgggcgcgtc gacgaaagcc 40441 gctgaccgtc gccgaactgg cagcgacgcc gctgctggtg cgcgagcccg gatcgggaac 40501 cagaacgact ctcgacctgg cgttacacga atacgagcgc ggtgcaccgt tgttggaact 40561 gggtagttcg gccgcgattc gaaccagcgt gctcggtggc gtcggcccgg cggtactgag 40621 cacgctggcc gtcgaggacc aggtgaagca gggagaactt cgggtcgtag ccgtcgaagg 40681 cttggaactc gaccgatccc tgcgtgcagt gtggcgcccg ccgcgtcagc tcgagggccc 40741 ctcaggcgac ctgatgaaag tagtgcgtgc cagcgggtcc cggaagtcct gaaagcggct 40801 tacttcttgt cggccttcgc tgctgccttt gcggccttct tgaactcgcg gacctcgagc 40861 aaagactgtt cgtcgaccac gtctgcaatc gagcgcctcg aaccttcgag cccgtagtcg 40921 ccggccgctt ggcgccaacc tttcggctcg acgccgatct gttttccgag caacgccagg 40981 aagatccggg ctttctgatc cccgtaaccg ggtagggctt tgagccgctt cagcacttcc 41041 ttgccgtcgg gatttcccga agtccagatc gccgcggtgt cgccgtcgta gttctcgacg 41101 atgaactggc acatgagctg gatacgctcg cccatcgact tggggaatcg gtgcacagcc 41161 ggaggctcgg cacagacggc gatgaactcg tcggtgtcca tgtcggcgat acgcctgacg 41221 tcgataccgc tgagccgatc cgccagcttc ttcggaccga ggaaggccgt ttccatcgga 41281 acctgttgat cgagaagcat tccgatcaac aacgccaacg ggtcctcggc gaggagagca 41341 tcagcttcgg ggtcaccgac aaggttcagt tgaagtgcca tgagtccgat actgccacgt 41401 caggcggcag ttgtgaccgg cgccgacgca tccggggccg gaatcttcca cttcttccag 41461 ccgaacagaa ccaccgtcga gaccgcggca agcgtgaaga cccagaggta gacgccgacg 41521 gtcggaatcc gcagatactc gggcggcacg aacatgaaca ggcccattcc gatgaagcga 41581 tccgtacccg gaatgaccga cgggtcccac caggtgtgag accagttcaa gaccgggagc 41641 aggaaaacga acggcgccac ccacgcccag cgcttcttcg acaccatcgc gtagtgcgcg 41701 gcgaggacga ccagcgggac gaaccacacc cagtgatggc cccacgagaa cggcgagaca 41761 gtggtcgcag tcaaccccgt catggtgagg ccgagcaatt tctggccgtg ccggtgagca 41821 atccacgcgg caccgagtcc gaggcatacc gccagcgcac tgaagactag aaccaggacc 41881 cgcgacggcg tcggagtgtg agtgagctga gcgatcagac cggacacgga ctggttgctc 41941 ggagcatccg tcggtccgac gcgttcgctg tcgacaagag tgccggtcca gtacttgtac 42001 gcatcgttgt agatcacgac gaagccgatc gcaacggtcg cagcgaacgt cacgacggcc 42061 gtcaccaacg cacgccattg acgagtgatg aagaggtacg cccagaagaa ggccggagtg 42121 agcttcacgc cggcggcgat gcctgccccg attcctcgga gccgactctt ctcgtcccga 42181 ccgaggtccc acacgatcaa gagcagcagg aagatgttga tctgcccgag ccagagcgtc 42241 gtacgtatcg gttccatgaa cagaaagatc gtcgtcgcca acgcactcac ggcgtacgcc 42301 ttcacgtcga gccgataacc gaggtacttc cagcacaaca agatcactgc gaacaacgca 42361 gcgatgttca aacccgtcca cacgacaatc gcctgtttga acgagagcac cgcccacacc 42421 gtgaacagca aagccgcaaa cggggtgtac gtgaacatca ttccgtccag gactggcccg 42481 tcgtacaacg gaaggccctg aaccacaacg ctgccgccgt ggcggtagac gtcgagatcg 42541 aggaaatttt cgaagatccc ccagtaccgc gtattcatcg gcacggcgaa aagaaccatc 42601 agcacggacg cgactgccag aacaccgagt acagagaatc cgagaacacc gacacggagg 42661 gtgcgtcgcg gtatgtcagc ttcgatgacc gactctgatt tcgcggtgtg cgcctcgaaa 42721 gaaggcccat ccgaagcgtt gatcgcgccc gtcactacaa cctccgggat ttacacccta 42781 tgtcgggaat tgatgctccg aacggtacaa gacaagaccg aaaagtaccg accgggcacg 42841 ccgcttcgag aactcagatc tcggagagac gcgattcggt agctgcgagc agaacacacg 42901 tagccacgcc gtccatggca acttcgagtt cagccttgga cgggaagctc ggggccaacc 42961 ggatgttccg gtcatccgga tccgtgctgt acgggaaagc cgacccggca gcggtgagcg 43021 cgatacccgc gttcttcgcc agttcgatga cccgcttggc cgtgccgtcg accacgtcga 43081 ggctgatgaa gtatccgccc ttcggctcgg tccaagacgc gaccttcgat gcaccgagac 43141 gatcctcgag gatccgcagt acgagctcga acttgggcgc gaggaacgcg cgatgcttct 43201 ccatgtgcgc acgaacgccg tcggcattgc cgaagaaacg caggtggcga agctgattga 43261 ccttgtccgg tccgatgctc ttcttgccca ggaacttctg gtaccaggca aggttttccg 43321 ccgagctacc gaagaagctc acaccagcgc cggcgaaagt gatcttggac gtcgacgcga 43381 acacgagcgg acggttgggg tgtccggcct ccgctgccat cgagagaatg tcgtaggaag 43441 gcgcagtctc gccgacaagc ggatgtacgg cgtacgcgtt gtcccagtac aggcggaagt 43501 cgggcgcggc cgtcggcatc gacgcgagcg tacggacaat ttcttcggag tacacggcac 43561 cggtggggtt cgcgtaaacc ggaaccgccc acatgccctt gatctgcgga tctgacgcaa 43621 caagttcggc gatcttgacg acatccgggc cgtcgtggtt catcggcacc gcgatcatct 43681 cgatgccgag ggactcggtg atcgcgaagt ggcggtcgta gcccggtgcc gggcagagaa 43741 acttgatctt ctcttcctgt gcccacggcc gggccgaatc cggtgtgcca tgaagcagtg 43801 agaacacgac gttgtcgtgc atgatctcga ggctcgcgtt gtttccggcg agaaggttcg 43861 caacggggat acccagcagc tcgccgaaga tggcgcgcag ttccggcaga ccggtgagtc 43921 cgccgtagtt acggcagtcg gtgccgcttc cgtcacggaa atcaccgtcg ccgggcagcg 43981 tcagcagctc tgcggaaagg tcgagttgtt ccggggaagg cttaccgcgg gtcagatcga 44041 gtgcgagctt ctgcgcctgg agctgcgtgt acttcgcgct ctggctctca tgctcggagg 44101 tgagttcttc atggctcatc aacccgatct gggtttggat aggcatccgg agcggccttt 44161 caccgacgag gcggggtcgg gtatgtgaaa aaatagagga ccccgcgcac ccggcagagc 44221 ccgttgaccc ttgctgcctt ccggccctgg gggagttcac aggatgcgcg ccgcgcggga 44281 tccaatgaac agtgtagacg gctttctccg gccgctgcac accacctacc ggggccgaga 44341 tgcaaacctc gagttccacc ggttcttcgc aggtcaggta cccgtttaac gcttcgcgcc 44401 cgcaattggg tatgctgctc cacggaggat tcgcctagtg gcctatggcg ctcgcctgga 44461 acgcgggttg ggttaacgcc ctcaggggtt caaatcccct atcctccgcc aaaggaaccc 44521 ctgtgaactg ctgagaagcg gttcacaggg gttcttttct gtcctcatgc aacgagtaat 44581 gcaacagggt ctcggttcag ctcgatgttc tgcgagctca gacggtctgc cgactcgtgg 44641 tggtttcgat cccgcagcgc gccgaatcgg aatgctgctg cgtgatttcg agtggcccgc 44701 cgatggcccg aacccgattc gggaagctat ggccacatct gctcctgcag cccgcgttgg 44761 tcatgaaatg acacccgcgc cgcaagtctt atttatccag atcccattct ggataagata 44821 ggcatggaaa gcaaggcggc aatatagcgt ggatacaggg agagaccaga tggcgtacag 44881 gacgttgaaa tcgatctttc accaacgaga tcgtgctggt gccgatgctg aggagcgagc 44941 gcgacgcgat tctcccgccg ccgtccactg ggacctactg atcggcgaac actcgacgtt 45001 cgcactgatg acacccgaag tcgcagcgct gatcgaacgg atcatgagct tcgagccgaa 45061 gatccgggct gagtggaacg ggctgccggc cctcgcgcgc acccactacc tgcatcgcat 45121 ggtgatcgac gagatccagg caacgaacga gatcgaacag gtccgctcaa cccggaagga 45181 gatcagcgag gcaatcgaga tggtgtgggc ggagcaaccc ctcgcgaaca agcggttcgc 45241 cgagatggtg cggctctatc tcaatatcgg caacgaccag gccgagagtc cgcagacgct 45301 cgacgacatc cgagacgtct acgacgcggt aactcggggc gagattcgcg acgaggacgc 45361 ccccgatggg aagcggttcc ggcaagggcc agtatcgatc acgtcaggaa tcaaggtcgt 45421 gcacaccggt gtggtacccg agtcagcgat cgacgacgcg ctgaccctca tgctgagcca 45481 ggggggcgac gactcgattc cacgactgat cagggcagtg gtcgcgcact tcatcttcga 45541 gtacacgcac ccgttctacg acggcaacgg ccgaaccgga cgctaccttc tcgcgctgga 45601 ccttcgacag gtgttggctc cgtatgcgag cctggcattg tcggcgaccg tcgccgacaa 45661 caaggatcgt tactacaaag cattctctga cgcggagaat ccattgaacc gcggagatct 45721 gacgccctac ctgatcgata tgctggagat catcgccgag gcgcaacatc gactgctgct 45781 cgacctctcc gagaggcggc ataagatcga cacactcgag gcgcgtatcc gcgttctggt 45841 ggaggatgag gaatttccgc tgaacttggg actcgatcgc gagtcgacgc cgccggttga 45901 tagcaaccac atcggcgcag tcctgttcac cctgggtcag gcccactgct tcgaggcgaa 45961 ccgcgccatc aagttgaaca ccctggtcga ggtggtgggt cgatccagcc agttcgcccg 46021 cccgcgactt cagcgcctgg acgatgccgg gatcattgag acggttacga agagaccgct 46081 gcgcttccgg ctcacggcac ggggggtatc g //