LOCUS NZ_JARDXE010000001 31803 bp DNA linear CON 01-APR-2024 DEFINITION Rhodococcus qingshengii strain HQ HQ1_scaffold1, whole genome shotgun sequence. ACCESSION NZ_JARDXE010000001 VERSION NZ_JARDXE010000001.1 KEYWORDS WGS; RefSeq. SOURCE Rhodococcus qingshengii ORGANISM Rhodococcus qingshengii Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae; Rhodococcus; Rhodococcus erythropolis group. REFERENCE 1 (bases 1 to 712350) AUTHORS Hu,J. and Xu,J. TITLE A novel hydrolase synthesized by Rhodococcus erythropolis HQ is responsible for the detoxification of Zearalenone JOURNAL Unpublished REFERENCE 2 (bases 1 to 712350) AUTHORS Hu,J. and Xu,J. TITLE Direct Submission JOURNAL Submitted (23-FEB-2023) Grain and Oil Risk Assessment Laboratory, Jiangsu Academy of Agricultural Sciences, No. 50, Zhongling Street, nanjing 210014, China COMMENT ##Genome-Assembly-Data-START## Assembly Date :: MAY-2022 Assembly Method :: ABySS v. 2.1.5 Genome Representation :: Full Expected Final Version :: Yes Reference-guided Assembly :: GCA_002079265.1 Genome Coverage :: 470.0x Sequencing Technology :: Illumina NovaSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_029076895.1-RS_2024_04_01 Annotation Date :: 04/01/2024 06:35:53 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,927 CDSs (total) :: 6,855 Genes (coding) :: 6,768 CDSs (with protein) :: 6,768 Genes (RNA) :: 72 rRNAs :: 1, 1, 1 (5S, 16S, 23S) complete rRNAs :: 1, 1, 1 (5S, 16S, 23S) tRNAs :: 66 ncRNAs :: 3 Pseudo Genes (total) :: 87 CDSs (without protein) :: 87 Pseudo Genes (ambiguous residues) :: 0 of 87 Pseudo Genes (frameshifted) :: 33 of 87 Pseudo Genes (incomplete) :: 63 of 87 Pseudo Genes (internal stop) :: 12 of 87 Pseudo Genes (multiple problems) :: 18 of 87 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-12 19:34:22 NOTE :: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 31803 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to JARDXE010000001.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..31803 /candidate_cluster_numbers="1" /contig_edge="True" /product="NAPAA" /region_number="1" /rules="(AMP-binding and TIGR02353)" /tool="antismash" cand_cluster 1..31803 /SMILES="NC([*])C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(AMP-binding and TIGR02353)" /kind="single" /product="NAPAA" /protoclusters="1" /tool="antismash" protocluster 1..31803 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[12909:16803](-)" /cutoff="5000" /detection_rule="(AMP-binding and TIGR02353)" /neighbourhood="15000" /product="NAPAA" /protocluster_number="1" /tool="antismash" proto_core complement(12910..16803) /aStool="rule-based-clusters" /tool="antismash" /cutoff="5000" /detection_rule="(AMP-binding and TIGR02353)" /neighbourhood="15000" /product="NAPAA" /protocluster_number="1" misc_feature complement(70..85) /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 23.11" /tool="antismash" gene complement(385..1779) /locus_tag="PXH69_RS00005" /old_locus_tag="PXH69_00005" CDS complement(385..1779) /GO_function="GO:0030170 - pyridoxal phosphate binding [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_1_2 (122-383). E-value: 4.1e-12. Score: 37.8. Matches aSDomain: nrpspksdomains_PXH69_RS00005_Aminotran_1_2.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019: aminotransferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727183.1" /locus_tag="PXH69_RS00005" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00005" /product="PLP-dependent aminotransferase family protein" /protein_id="WP_275231293.1" /sec_met_domain="Aminotran_1_2 (E-value: 4.7e-11, bitscore: 37.7, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MVNSWANLGFDLHIELPQGIGVRAALLQTLRDAIDSGLLKPGTRL PPSRTLALDLGVARNTVADCYAELAAAGWLVTRPGSGTLVATLASTHTREVEPSPTRRR WTYSLLPGSPDASAFPRTAWISSARRALTTAPTDAFATTDPRGRVELRNALTTYLSRTR GVRVDPSCIVISASSGHGISLLARALGGTIAVDAFCLHLHRQLLADEGLLTVPISVDQS GTCTDELASTSAESVLLTPTHQFPLGGPLTPARRATALEWATTTGGVIIEDDYDGEFRY DRKPVGALQGIAPQHVAYLGTVSKTLSPAIRIGWMVLPDRLIEPVLATKGPYERWVSST DQLTLADFIESGRFDSHIRKMRTSYRRRRDQLVATLAQQVPQVRVEGISAGLHAVIRLP SGTEQSVLAAARARDLGLEGLSVFRHPDVSSVGGDGIVVGYSTPMQSQYSRTLDVLCEV LQAALR" aSDomain complement(631..1413) /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00005_Aminotran_1_2.1" /evalue="4.10E-12" /label="PXH69_RS00005_Aminotran_1_2.1" /locus_tag="PXH69_RS00005" /protein_end="383" /protein_start="122" /score="37.8" /tool="antismash" /translation="AWISSARRALTTAPTDAFATTDPRGRVELRNALTTYLSRTRGVRV DPSCIVISASSGHGISLLARALGGTIAVDAFCLHLHRQLLADEGLLTVPISVDQSGTCT DELASTSAESVLLTPTHQFPLGGPLTPARRATALEWATTTGGVIIEDDYDGEFRYDRKP VGALQGIAPQHVAYLGTVSKTLSPAIRIGWMVLPDRLIEPVLATKGPYERWVSSTDQLT LADFIESGRFDSHIRKMRTSYRRRRDQLVATLAQQVPQV" gene 1827..2285 /locus_tag="PXH69_RS00010" /old_locus_tag="PXH69_00010" CDS 1827..2285 /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1298: putative carboxymuconolactone decarboxylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727180.1" /locus_tag="PXH69_RS00010" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00010" /product="carboxymuconolactone decarboxylase family protein" /protein_id="WP_007727180.1" /transl_table=11 /translation="MTTATGQRLDIAKLAPEVYKAMIALDAAARKGLEPTLVELVLTRA SQLNHCAWCLDMHTRDARKVGVTEQKLYLLNAWEEARGMYSDRERAALALTEAVTVLTD GFVPDEVYSEAAGEFSDVELAQLISVILTINAWNRIAVTTRKAPPVRD" misc_feature complement(2413..2428) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: strong, score: 19.26" /tool="antismash" gene 2911..4371 /locus_tag="PXH69_RS00015" /old_locus_tag="PXH69_00015" CDS 2911..4371 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727176.1" /locus_tag="PXH69_RS00015" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00015" /product="hypothetical protein" /protein_id="WP_275231294.1" /transl_table=11 /translation="MTVSGSRRRPLVLRLSLTAAIAVTVAGSSVAFASPAVSAPMPVRT AAAPAFTAGLCEGTEYTPSEQMLDISGIRLDHYNDGNIVPMYGTTDRGTSAAVDAPVCG VRDVDGIAKSEWMYCTDFDLDPCAGVDENGLPVDKHNDEMGATVPSSGNPDLSADDLAV ISWLLQNPAKLDGVVSGNGSEDARSARQTLVWCVSDYDNPLMADFKSLCDRNIGDDERA RIVEIMNVTQTLDLVRKTPATGTLKAGETAVFTLNTNMYRKPITVQSSAGTELTVCGDN AKATLTANQLTVDGRGDAPTAVDLCLTAAAGGDYSVTASVIPDSVENLHWNTAGAQCQI FASFDTVRPASMNASASVGYAAAPTTTPATSTPATSTPATTTPATTTPATTTPATPVVP IVPIVPIVPIVPIVPVVPGAPVPSQPVATPATPAPSAPKPATGPRPVAIDGGAAEQNSG RNVAVAVTGLGLVGMAAAGAVALRRKRS" misc_feature 4403..4416 /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 19.33" /tool="antismash" gene 4501..5199 /locus_tag="PXH69_RS00020" /old_locus_tag="PXH69_00020" CDS 4501..5199 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727173.1" /locus_tag="PXH69_RS00020" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00020" /product="class F sortase" /protein_id="WP_228401760.1" /transl_table=11 /translation="MTMYESDPNPSNPYDDPNHDQPASPGKGRRVAFILALIAVLVAGA SMAFVGLRSSDDDAAIPPSPGVVMSHSANPAAPTDALMTPNTLSLDPVGVQAPIVDATV PEGVLTPPENVKNVGIWLDGASLDSATGTTLIAGHVNLTGQGNGALFDLGTIEPGEVIR TSDATGKSTSWKVTAVTTRPKADGVEESVLAGPEGPRKLAVVTCGGELQFEDGVGNYAD NVYLYADLMV" gene 5277..6074 /locus_tag="PXH69_RS00025" /old_locus_tag="PXH69_00025" CDS 5277..6074 /NRPS_PKS="Domain: PKS_KR (10-125). E-value: 5.6e-07. Score: 21.6. Matches aSDomain: nrpspksdomains_PXH69_RS00025_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005570226.1" /locus_tag="PXH69_RS00025" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00025" /product="SDR family oxidoreductase" /protein_id="WP_275231295.1" /transl_table=11 /translation="MDLHLSGKRAIVAGGSKGIGLAIARGLAAEGVDIAILARTERTVV SVPRDLVSEFGIRAIGVVTDTRDDDAVQASVRQVVEEFGGVDILVNSAATPFSAGKPTD FEATTDDVVRDEVEVKVLGYLRTARAVAPYLIDQGWGRIINISGLGARQATSIAHTIRN VSVSALTKNLADELGPKGINVTVVHPGVTRTERLTARITRESEESGRSQAEVERGIATN SIHRIIDAEEVADVVTFLASPRSIAITGDAVAAGGGVPGPVYY" CDS_motif 5307..5387 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00025_0001" /evalue="1.30E-04" /label="PKSI-KR_m1" /locus_tag="PXH69_RS00025" /protein_end="37" /protein_start="10" /score="14.7" /tool="antismash" /translation="IVAGGSKGIGLAIARGLAAEGVDIAIL" aSDomain 5307..5651 /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00025_PKS_KR.1" /evalue="5.60E-07" /label="PXH69_RS00025_PKS_KR.1" /locus_tag="PXH69_RS00025" /protein_end="125" /protein_start="10" /score="21.6" /specificity="KR activity: inactive" /specificity="KR stereochemistry: C1" /tool="antismash" /translation="IVAGGSKGIGLAIARGLAAEGVDIAILARTERTVVSVPRDLVSEF GIRAIGVVTDTRDDDAVQASVRQVVEEFGGVDILVNSAATPFSAGKPTDFEATTDDVVR DEVEVKVLGYL" gene complement(6089..7210) /locus_tag="PXH69_RS00030" /old_locus_tag="PXH69_00030" CDS complement(6089..7210) /EC_number="2.7.7.65" /GO_component="GO:0005886 - plasma membrane [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1025: diguanylate cyclase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727167.1" /locus_tag="PXH69_RS00030" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00030" /product="GGDEF domain-containing protein" /protein_id="WP_125050252.1" /transl_table=11 /translation="MTSQMKSMRTLTREWLILPDQYDRFTRYLRDNGLTTATRLLLGII VIGLGVCALLNRFSPAGPTSTIALFFNTAVVISCFVVGVSWWVFGPTKRRSFGFVVFCD IAVTISVVGDSSQLARLLTCVIFALVGIYIAYFHNPKLQIAHIAFSLLVIAVAAQPILF GPDRDPALGVSKVLVVITALVVCAFISQIVLTMLSMDASSSDLDPLTGLLNRRGLDRHV EKVLEGFQRQESAALLVIAIDIDRFKTINDVHGHDVGDRIILRVSQRLSAWAHADAVVA RVGGDEFILVQRLSVPAIGPMLNSIGPAMHSNSDEIPSTSSIGIAVRTHKFVAGEDRAA AFTDMQKVADSAMYESKRLGGGRVHTIVTTAGR" gene 7386..8030 /locus_tag="PXH69_RS00035" /old_locus_tag="PXH69_00035" CDS 7386..8030 /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1071: GntR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746670.1" /locus_tag="PXH69_RS00035" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00035" /product="GntR family transcriptional regulator" /protein_id="WP_007727164.1" /transl_table=11 /translation="MLYSASETVFREVKELILSGELAGGELISEGDIAARTNVSRTPVR EAFLRLESEGWMRLYPKKGALIVPVADGEAEHVVSARQLVETQSVRVVSVRPHAREALV AALRANLIEQREIADRGDVAAFSAIDADFHKMIVAAGGNPLLDSFYASLRDRQRRMTAR SISRDPGQLSRILADHTALTDLVDTGDADGYNTAVLTHMRQVHGLGFEGTL" gene 8030..9304 /locus_tag="PXH69_RS00040" /old_locus_tag="PXH69_00040" CDS 8030..9304 /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1202: major facilitator transporter" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003941086.1" /locus_tag="PXH69_RS00040" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00040" /product="MFS transporter" /protein_id="WP_275231296.1" /transl_table=11 /translation="MSTQTIGAGTAAETRLEGERLSGGKWLWLTVAASMFAAAWGGNEF TPLLVMYRLDHGYSPVMVDFFLFAYVVGIVPALLLGGPLSDRLGRRPIMLPSPIIAIAG STLLAFGADSAAALILGRILCGIALGIGMAVGGSWVKELSTQPWDPTASEGAGARRAAM SLTAGFALGAGAAGILAQWAPMPSVLAYVLHIAITVLAAMALWRAPETRPAQAKSDRRR LIDDLKIPSAGHRRFLYVVVPLAPWVFGAASVAYAVIPALMTGHSGDAPVAFSALLCMV ALTCGFAIQSLGRKIDTDRSARGAVVALVFLVVGMAGAALVASTLTVAIAIVAAAILGC GYGMALVSGLLEIQRIAGPDDLAGLTAVFYSITYIGFAVPALLAMLSESIPALSYTVTL LFGSAAAAACLILILFKSRSHLPSA" gene complement(9350..10921) /locus_tag="PXH69_RS00045" /old_locus_tag="PXH69_00045" CDS complement(9350..10921) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003941083.1" /locus_tag="PXH69_RS00045" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00045" /product="flotillin family protein" /protein_id="WP_003941083.1" /transl_table=11 /translation="MLPIIIIAVVVAVIIFIVLPAIYVKNYVKVPPNEVAVFTGRGKPK VVRGGARFKIPGIERVDIMSLEPFNVSINLKNALSNDGVPVNVEAVGLVRIGSADEAVQ TAVQRFLTSDLDELQQQINEILAGSLRGITATMTVEDLNSNRDSLARSVVEEAGGDLAR IGMEVDVIKIAGISDFNGYLESLGQRRIAEVKRDAAIGTAEAERDSQIQSAKARQAGSV AQAEADTAIASANQKRDVELARLRAQTEAENAEADQAGPLAQATAEKAVGIAREQAEAA RVEARTEVERRRAQQSEAALQADVIAPAEAERQASIARAEGERQAAILRAQAQAESARQ AGGAQADARKLVADAVRSEQQADADGLRARLEAEADGRKVAADAVRAEQQAEADGLRAK LEAEAAGKRQIAEALNSYTPQAAQLLTLPDVLAALVDATAAAAKPVGDIDRISIVGGSD GAQGSIGSILGISPQVIAGVIETLESSGVDITGLLNGLNKTASVPAGSVHNSVHSSENG SATVDA" misc_feature 10901..10916 /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: weak, score: 19.85" /tool="antismash" gene complement(10933..11448) /locus_tag="PXH69_RS00050" /old_locus_tag="PXH69_00050" CDS complement(10933..11448) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727150.1" /locus_tag="PXH69_RS00050" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00050" /product="DUF1449 family protein" /protein_id="WP_064443044.1" /transl_table=11 /translation="MFVVFTICFVIGVVALIGAFAVGEVADLGGGHADGLPFLSLTTLA TALFGFGAGGVAATLADAPTLVAAIAALALAAVLVVVTRGLLLPYLIKQQDNSHIGRAS YSGLLGTVTLTIAAEGWGEVSFVDAEGNRVQAKAVSAQPMALTTGTTVYIADVDDQYLH VVTVDDAI" misc_feature complement(11529..11547) /note="TFBS match to DmdR1, Iron(II)-dependent repressor, confidence: weak, score: 23.27" /tool="antismash" gene complement(11597..12898) /locus_tag="PXH69_RS00055" /old_locus_tag="PXH69_00055" CDS complement(11597..12898) /EC_number="3.4.11.-" /GO_function="GO:0004177 - aminopeptidase activity [Evidence IEA]" /GO_function="GO:0008237 - metallopeptidase activity [Evidence IEA]" /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011596802.1" /locus_tag="PXH69_RS00055" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00055" /product="M1 family metallopeptidase" /protein_id="WP_050655931.1" /transl_table=11 /translation="MLEEPIDPYLPLNGNRGYRVSRYELELTYKVFSNRLAGKAVITAV TTESRSKFSFDLAQNLQVSKVSVNGARGTKYAHLNNKLILTPSTKIPAGGALSVTIAYS GNPEPIKSLWGEVGWEELDEGTLVASQPNGAASWFPCDDHPISKASYRISITTDSPFYA LANGKLIRKQTRASQTTWVYEQTEPMATYLATIQIGQYEHRQVSAGPVPVFAVHPPRLR AAFDVDFGRQPQMLEVFGKLFGPYPFADYTAVVTDDELEIPIEAQGLSIFGANHCTGRR GSERLVAHELAHQWFGNSLTLGQWCDIWLHEGFACYAEWIWSENSGGPSSNQLATNAYQ GLGRKSQDLIVANPGPALMFDDRIYKRGALTLHALRGVLGDEKFFELIRQWTTKHRHST VSTEQFTDLASRFTDTPLRPLWDAWLNQRSLPRL" gene complement(12910..16803) /locus_tag="PXH69_RS00060" /old_locus_tag="PXH69_00060" CDS complement(12910..16803) /GO_function="GO:1904091 - non-ribosomal peptide synthetase activity [Evidence IEA]" /NRPS_PKS="Domain: AMP-binding (35-410). E-value: 1.1e-76. Score: 250.0. Matches aSDomain: nrpspksdomains_PXH69_RS00060_AMP-binding.1" /NRPS_PKS="Domain: PP-binding (519-582). E-value: 9.6e-16. Score: 49.9. Matches aSDomain: nrpspksdomains_PXH69_RS00060_PP-binding.1" /NRPS_PKS="Domain: TIGR02353 (605-1291). E-value: 1.1e-227. Score: 749.5. Matches aSDomain: nrpspksdomains_PXH69_RS00060_TIGR02353.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) NAPAA: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NAPAA: TIGR02353" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009477449.1" /locus_tag="PXH69_RS00060" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00060" /product="Pls/PosA family non-ribosomal peptide synthetase" /protein_id="WP_275231443.1" /sec_met_domain="AMP-binding (E-value: 1.8e-78, bitscore: 259.2, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 1.2e-13, bitscore: 46.7, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="TIGR02353 (E-value: 1.1e-226, bitscore: 749.5, seeds: 6, tool: rule-based-clusters)" /transl_table=11 /translation="MPLQSQSETEQSFGIPSVFLRSAHAPAPRTLIDIVRASAEANPEA PAIDDGDTTLSYSELLDEIALGARWLGDAGVGAGDRVGIRMPSGSRSLYVAILSILAAG AAYVPVDADDPEERAELVFGEAQVAAIITGDGIQPGTAPKRLEHPPVREPEPEDDAWII FTSGSTGTPKGVAVTHLNAAAFVDAEARMFLQDEPIGPGDRVLAGLSVAFDASCEEMWL AWRHGACLVPAPRSLVRSGMDLGPWLVSRDVSIVSTVPTLASLWPAEALEAVRLLIFGG EACPPELAERLAVEGREVWNTYGPTEATVVACGALMDGKSPVSIGLPLDGWDLAVVDAQ SNPVAVGEVGELVIGGVGLARYLDPAKDAEKYASMPSLGWDRAYRSGDLVRLETTGLMF QGRADDQVKLGGRRIELGEVDNALQNLPGVSGAAAAVKKTAAGNQLLVGYIASTDPDFD LKAAHALLSEQLPAALVPRLALMDELPTRTSGKVDRNALPWPLPGAGEDAGAALGLDGT AAWVAGLWGSILGAQITGLDDDFFEVGGGSLSAAQLVTALRERFPEVTVAQLYDHPRLG SLAEYLDELAPTETVEPRIVAPTPFKTQLAQIAVTVPLTTLTGLQWVTWLAIANNVLGW FVDVSWAPTVSWWWILLAFIVFITPIGRMTIAVVGARLLLRKLEPGTYPRGGSEHLRLW IALRLTEASGAANLSGAPWMLYYARALGADIGSGVDLHTLPPITGMLELGDGCSVEPEV DLSGHWIDGDVIHIGEIKIGDGASVGSRSTLLPGARIGRDAVVEPGSAVFGRVKANQQW AGSPATKVGKANHPWPAEHPKRAPGWVPVYGVTSVFLAGMPIFALMAGIALIGWWIRDT DTLASAVLQSLIMLPVATILSLLVFAVVTLVAVRLLSIGLTPGYHPVRSRIGWQVWATE RLLDSARTFLFPLYASLLTPGWLRLLGAKIGKNVEASTVLLLPKFTTVADGAFLADDTM VASYGLGGGWMHIEQAKIGKRAFLGNSGMTAPGRRVPKNGLVAVLSATPSKAKSGSSWL GSPPVRLRRAAGDTDAARTFNPPMRLKIARGVVETCRLIPVMVTFGIGLGVLFALEALV GAVGFWFAALLSGVILLVAGAVAGAITIAAKWIVVGRIAKVEHPLWSSFVWRNEVADAF VETVAAPWFARAATGTAVLNIFLRGLGAKIGKGVWCESYWLPEADLVTLGDGATVERGC VVQTHLFHDRIMSMDTVTLGAGATLGPHCVALPAAGIGAGATVGPASLVMRGDTVPPST RWQGNPIAPWVAS" aSDomain complement(12931..14988) /aSDomain="TIGR02353" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00060_TIGR02353.1" /evalue="1.10E-227" /label="PXH69_RS00060_TIGR02353.1" /locus_tag="PXH69_RS00060" /protein_end="1291" /protein_start="605" /score="749.5" /tool="antismash" /translation="AQIAVTVPLTTLTGLQWVTWLAIANNVLGWFVDVSWAPTVSWWWI LLAFIVFITPIGRMTIAVVGARLLLRKLEPGTYPRGGSEHLRLWIALRLTEASGAANLS GAPWMLYYARALGADIGSGVDLHTLPPITGMLELGDGCSVEPEVDLSGHWIDGDVIHIG EIKIGDGASVGSRSTLLPGARIGRDAVVEPGSAVFGRVKANQQWAGSPATKVGKANHPW PAEHPKRAPGWVPVYGVTSVFLAGMPIFALMAGIALIGWWIRDTDTLASAVLQSLIMLP VATILSLLVFAVVTLVAVRLLSIGLTPGYHPVRSRIGWQVWATERLLDSARTFLFPLYA SLLTPGWLRLLGAKIGKNVEASTVLLLPKFTTVADGAFLADDTMVASYGLGGGWMHIEQ AKIGKRAFLGNSGMTAPGRRVPKNGLVAVLSATPSKAKSGSSWLGSPPVRLRRAAGDTD AARTFNPPMRLKIARGVVETCRLIPVMVTFGIGLGVLFALEALVGAVGFWFAALLSGVI LLVAGAVAGAITIAAKWIVVGRIAKVEHPLWSSFVWRNEVADAFVETVAAPWFARAATG TAVLNIFLRGLGAKIGKGVWCESYWLPEADLVTLGDGATVERGCVVQTHLFHDRIMSMD TVTLGAGATLGPHCVALPAAGIGAGATVGPASLVMRGDTVPPSTRWQGNPI" aSModule complement(12931..16698) /complete /domains="nrpspksdomains_PXH69_RS00060_AMP-binding.1" /domains="nrpspksdomains_PXH69_RS00060_PP-binding.1" /domains="nrpspksdomains_PXH69_RS00060_TIGR02353.1" /locus_tags="PXH69_RS00060" /monomer_pairings="X -> X" /starter_module /tool="antismash" /type="nrps" CDS_motif complement(14494..14529) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00060_0006" /evalue="6.30E+01" /label="NRPS-A_a8" /locus_tag="PXH69_RS00060" /protein_end="770" /protein_start="758" /score="-2.9" /tool="antismash" /translation="WIDGDVIHIGEI" aSDomain complement(15058..15246) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00060_PP-binding.1" /evalue="9.60E-16" /label="PXH69_RS00060_PP-binding.1" /locus_tag="PXH69_RS00060" /protein_end="582" /protein_start="519" /score="49.9" /tool="antismash" /translation="WVAGLWGSILGAQITGLDDDFFEVGGGSLSAAQLVTALRERFPEV TVAQLYDHPRLGSLAEYL" CDS_motif complement(15547..15609) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00060_0005" /evalue="3.60E-09" /label="NRPS-A_a8" /locus_tag="PXH69_RS00060" /protein_end="419" /protein_start="398" /score="28.8" /tool="antismash" /translation="FQGRADDQVKLGGRRIELGEV" aSDomain complement(15574..16698) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00060_AMP-binding.1" /evalue="1.10E-76" /label="PXH69_RS00060_AMP-binding.1" /locus_tag="PXH69_RS00060" /protein_end="410" /protein_start="35" /score="250.0" /specificity="substrate consensus: X" /tool="antismash" /translation="RASAEANPEAPAIDDGDTTLSYSELLDEIALGARWLGDAGVGAGD RVGIRMPSGSRSLYVAILSILAAGAAYVPVDADDPEERAELVFGEAQVAAIITGDGIQP GTAPKRLEHPPVREPEPEDDAWIIFTSGSTGTPKGVAVTHLNAAAFVDAEARMFLQDEP IGPGDRVLAGLSVAFDASCEEMWLAWRHGACLVPAPRSLVRSGMDLGPWLVSRDVSIVS TVPTLASLWPAEALEAVRLLIFGGEACPPELAERLAVEGREVWNTYGPTEATVVACGAL MDGKSPVSIGLPLDGWDLAVVDAQSNPVAVGEVGELVIGGVGLARYLDPAKDAEKYASM PSLGWDRAYRSGDLVRLETTGLMFQGRADDQVKLG" CDS_motif complement(15694..15768) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00060_0004" /evalue="4.20E-06" /label="NRPS-A_a6" /locus_tag="PXH69_RS00060" /protein_end="370" /protein_start="345" /score="19.2" /tool="antismash" /translation="VGEVGELVIGGVGLARYLDPAKDAE" CDS_motif complement(16108..16134) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00060_0003" /evalue="9.90E+01" /label="NRPS-A_a2" /locus_tag="PXH69_RS00060" /protein_end="232" /protein_start="223" /score="-3.1" /tool="antismash" /translation="WRHGACLVP" CDS_motif complement(16267..16326) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00060_0002" /evalue="2.00E-09" /label="NRPS-A_a3" /locus_tag="PXH69_RS00060" /protein_end="179" /protein_start="159" /score="29.5" /tool="antismash" /translation="AWIIFTSGSTGTPKGVAVTH" CDS_motif complement(16471..16512) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00060_0001" /evalue="5.50E-04" /label="NRPS-A_a2" /locus_tag="PXH69_RS00060" /protein_end="111" /protein_start="97" /score="13.4" /tool="antismash" /translation="LSILAAGAAYVPVD" gene complement(16926..18779) /locus_tag="PXH69_RS00065" /old_locus_tag="PXH69_00065" CDS complement(16926..18779) /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0071705 - nitrogen compound transport [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003941118.1" /locus_tag="PXH69_RS00065" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00065" /product="BCCT family transporter" /protein_id="WP_054187858.1" /transl_table=11 /translation="MTAVKTAWRELRKPVFIPASIVIFALIAFAVIYAGTAADAFETLN NVISDGVGWWYILSATGFVIFALYCGISRIGNIRLGRDDEQPEFGMLSWFAMLFSAGMG IGLVFYGVAEPLSHYVTPPVAGQIAGSTDAAANQAMELTLFHWGLHAWAIYVVVGLGLA YMTYRKGRPLSIRWLLEPLLGRARIEGKIGHAIDVVAIVGTLFGVATSLGFGVQQISAG LDYLGWVETDNWLVITIIVIVTGMATFSVVSGVTKGLKWLSNINMMLAAALALFVLILG PTLFLMQSWVQNLGGYVQALPELMLRTSPFAEDGWQGAWTIFYWGWWMSWAPFVGMFIA RISRGRTIREFVFGVLLAPTLVGSLWFTIFGNSGILRQRNEGTMLDASGAVDTNTSLFT LLDGLPLGTISSVLAIVVIVFFFVTSADSGSIVIDILATGGSLETSKITRVYWTFLSGA AAAVLLIVGGSGSLTALQTVAIATAVPFSVIMVLACLSMLKAFRYEVASAPRYLRVSTN TSASTDVPQPTEKRLRDLKISSTFAGLTPSQSGIMTDPSDAHMLVAVHEVPAHAVNIDP DTGAVDFSEESKVVDPLGGEVFDTPEFADSAEGHAQAASTD" gene complement(19208..19510) /locus_tag="PXH69_RS00070" /old_locus_tag="PXH69_00070" CDS complement(19208..19510) /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="PXH69_RS00070" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="PXH69_00070" /product="hypothetical protein" /protein_id="WP_275231297.1" /transl_table=11 /translation="MTTEPTTGNWVRLAIWLFATAGFAYGTVQAWRNRNKPQSVWWEGT TAPTEIPADDVRSALASTDDRIPAIKALRELHPGFGLKDAMDLIDAQRGEQGPHH" gene 19652..19978 /locus_tag="PXH69_RS00075" /old_locus_tag="PXH69_00075" CDS 19652..19978 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746678.1" /locus_tag="PXH69_RS00075" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00075" /product="hypothetical protein" /protein_id="WP_039972778.1" /transl_table=11 /translation="MEIMEIRDAVERFRGESGTSTIFGEPHQTSDGSTIITVSRLHRRW RRDPIPVPVGVFSIHEGEPSWSPAVDHTRAALMGEFIGLAAAVIATLAVLRRPPWPDVT IQKG" gene complement(19966..20106) /locus_tag="PXH69_RS00080" /old_locus_tag="PXH69_00080" CDS complement(19966..20106) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003941170.1" /locus_tag="PXH69_RS00080" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00080" /product="hypothetical protein" /protein_id="WP_003941170.1" /transl_table=11 /translation="MGSADVMAWLAEGYLAGDPIRYPLYVGSMFLAMPFQLIGVILGHP F" misc_feature 20157..20173 /note="TFBS match to HexR, Glucose-responsive regulator, confidence: weak, score: 19.13" /tool="antismash" misc_feature 20161..20170 /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: medium, score: 16.08" /tool="antismash" gene 20351..21082 /locus_tag="PXH69_RS00085" /old_locus_tag="PXH69_00085" CDS 20351..21082 /NRPS_PKS="Domain: PKS_KR (11-161). E-value: 5.3e-13. Score: 41.2. Matches aSDomain: nrpspksdomains_PXH69_RS00085_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1001: short-chain dehydrogenase/reductase SDR" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017207344.1" /locus_tag="PXH69_RS00085" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00085" /product="SDR family oxidoreductase" /protein_id="WP_042922757.1" /transl_table=11 /translation="MTTTPSPLSGKTVVLIGGGTGIGLRVAQLAVDAGAQVVLGGRTAS KLEAAAAQLGEAAHWFTVDTSDDDSVKAFFTNIPSVDALFTTAADYQVGSFREQSVEEA ASPFTSKFWGQYRVVHAALDKLTPTASVVLMSGAASVRPPAAAAAYVAANAAIEGLGRG LAVELSPIRVNTVAPGTIDGHLWAQRPAEVREAAFTWSAENNVLGRVGNEDEIAQAVFY LFTNTYTTGSTLYPDGGYALR" CDS_motif 20384..20479 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00085_0001" /evalue="3.00E-03" /label="PKSI-KR_m1" /locus_tag="PXH69_RS00085" /protein_end="43" /protein_start="11" /score="10.3" /tool="antismash" /translation="TVVLIGGGTGIGLRVAQLAVDAGAQVVLGGRT" aSDomain 20384..20833 /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00085_PKS_KR.1" /evalue="5.30E-13" /label="PXH69_RS00085_PKS_KR.1" /locus_tag="PXH69_RS00085" /protein_end="161" /protein_start="11" /score="41.2" /specificity="KR activity: active" /specificity="KR stereochemistry: (unknown)" /tool="antismash" /translation="TVVLIGGGTGIGLRVAQLAVDAGAQVVLGGRTASKLEAAAAQLGE AAHWFTVDTSDDDSVKAFFTNIPSVDALFTTAADYQVGSFREQSVEEAASPFTSKFWGQ YRVVHAALDKLTPTASVVLMSGAASVRPPAAAAAYVAANAAIEGLG" CDS_motif 20747..20830 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_PXH69_RS00085_0002" /evalue="2.40E-03" /label="PKSI-KR_m4" /locus_tag="PXH69_RS00085" /protein_end="160" /protein_start="132" /score="10.4" /tool="antismash" /translation="VLMSGAASVRPPAAAAAYVAANAAIEGL" misc_feature complement(21119..21131) /note="TFBS match to LuxO, Repressor of luminescence, confidence: weak, score: 18.12" /tool="antismash" misc_feature complement(21234..21249) /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 20.99" /tool="antismash" gene 21234..22601 /locus_tag="PXH69_RS00090" /old_locus_tag="PXH69_00090" CDS 21234..22601 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746680.1" /locus_tag="PXH69_RS00090" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00090" /product="cytosine permease" /protein_id="WP_054187860.1" /transl_table=11 /translation="MKNTSATAAGGEVSDGDDYALTRVPDEARYSWFSVAVQRFGQVSA LAQFLLGATLGYGMTFWNAFWALTVGAVILEVVCIFIGIIGVREGLNTSVVARWCGFGH AGSAVIGLVIGVSLIGWFGIQSAVSASGLHGIMPFLPQWAWALAFGLLITAIVLRGFGS MQLIANITVPLFLILVGWAVVAELRNHSLSDLMTSAPAGPELSFLAGTTIVAGGFIAGA VITPDMTRFNRTAGDVVKQTLVGITLGEYVIGLTGVLLAHAVRSSDIATIILSSVGWVG VLIIVLGTFKINDWNLYSSGLGVVNFIDVVFGRRINRAVVTAVVGITGSVLAAAGILNS FTDFLILLGVGFPPIAGIMVAEYFIVKTWRKDLEESRAAGTLPNSAPTWVPATLVIWIV SALIGHYSTFGLPSINAVASAFVLYVVAGRLGLIRGVGRTATEAPQETSGKSALTH" gene 22632..24212 /locus_tag="PXH69_RS00095" /old_locus_tag="PXH69_00095" CDS 22632..24212 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727140.1" /locus_tag="PXH69_RS00095" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00095" /product="hydantoinase/oxoprolinase family protein" /protein_id="WP_054828020.1" /transl_table=11 /translation="MRIGIDVGGTNTDAVLMDGTTVIGHVKHSTSKDITGGIGGALTAL QQQYSFSPSAVQAVMIGTTHFLNALIEQRGLAPTAALRLGLPATAALPPMVGWPRDLVS AVQGRRYLAHGGHEFDGRRISSLDPDEIRRHAAAMARSGTRSVAISSVFSPVNLECEAA AAEIVREELGLDVAISLSHEIGRVGLLQRENATIINAALRELADHIVDGLARSLVEHGI VAPLYLSQNDGTLMDIEYARRYPVATFASGPTNSMRGAAVLSGLASCAVIDIGGTTTDV GVLTNGFPREATTEVTVAGVRTNFRMPDVFSIGIGGGSLVDADGLTVGPESVGYELGSR ALVFGGDTLTATDIAVAAGLADVGDRSAVAHLDRGLVSTALDRISRRVADAVEQMRTTS DPLPVVAVGGGSVLLERELPGLGMVIRPERFDVANAIGAAIAQVSGEVDRVEAVRDGHR QVFADDARQEAIDRAVAAGARPESVQIVEFDEVPIPYLPGNATRIRVKAVGDLALHSGL VSIGQEGSR" misc_feature complement(22644..22658) /note="TFBS match to MexT, Global virulence regulator, confidence: weak, score: 17.3" /tool="antismash" gene 24209..25318 /locus_tag="PXH69_RS00100" /old_locus_tag="PXH69_00100" CDS 24209..25318 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746682.1" /locus_tag="PXH69_RS00100" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00100" /product="DUF917 domain-containing protein" /protein_id="WP_050655919.1" /transl_table=11 /translation="MSWTLRTADLDDLARGAALLGTGGGGDPFVGKMLVTQALGEAGEI TILDPEELDDDAWVIPVAQMGAPTVVVEKMPRGTEPELALITLEKHTGRTADATMPMEC GGINSMIPLLVAARRGLPVVDADGMGRAFPQLEMETFSVYGISASPLAMANEHDEVAIF DTGSDNSRLEGLARGVTSRFGGMAHIAQYSMTGADVKRTAIPRTLSLAMTIGRSIRLSR EQRVDPVQALVDSLADTLYGYGRVLFHGKVIDVDRRTDEGFARGSVRIAGVGDEELEVQ FQNENLIAVQSGVMVAIVPDLICIVEADTAEPITTEGLRYGQRVAVIGIATPPIMRTPE ALAVFGPASFGLDRPFLPVETLEQPVLAE" gene 25325..26383 /locus_tag="PXH69_RS00105" /old_locus_tag="PXH69_00105" CDS 25325..26383 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727136.1" /locus_tag="PXH69_RS00105" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00105" /product="DUF917 domain-containing protein" /protein_id="WP_047269700.1" /transl_table=11 /translation="MSRLHAVREADLDAIAAGAVVLGCGGGGDPRLFVELLRPLMTSTS VEVIAPDQLPEEALVMPVGIVGSALALEEQLPSGREFADTAAALTRWTGKRPTAVMTFE GGGLNALSGIAAALALGIPVVDADLLGRAMPRLDHFSLAAAGLELCPVTLAQPGGLITV VDGVDVLGAEVAVRSLIGRTSGWGALAIASIDARTVQEACIPGTLSRAHELGQHIGALG SWQEIAESSGALVMGTGRVRAVRRSRPDTGDRRGSVILEHDSAVIRVEFESEFLTVALD GEMIATCPDIVTLLDVRTGAFVSCESVHQGHDVAVLVLPGPQWWADEVGRLKVVGPRAF GIDHDAVLMEAR" gene 26380..27915 /locus_tag="PXH69_RS00110" /old_locus_tag="PXH69_00110" CDS 26380..27915 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746684.1" /locus_tag="PXH69_RS00110" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00110" /product="helix-turn-helix domain-containing protein" /protein_id="WP_047269699.1" /transl_table=11 /translation="MSASVSALLNNPAFVGLYRLAGEGDPVVTTVGALTGESAQSAEAV SGAASSGSVLVILDRIDIGEWRFDALLRRTAATGCQVVAVHSAAAEDANLSLLADRLGL VVLGVSDPWQFSVDLRDLLSNSRAVMADAVLRATHAGQRAGGSVENLLSVLLNTFQRSF FLLDTSGRPMTGADLLSDADRAAAGMLSGRGAPTTVELDSGGVLIACPVMSGAAREPWL AVLLPVRQSVEEASLSVVLDVASLAAGHRLAVARMVDEREARRRSALLGELIDTSADAT PGLLRRALDAGWMLDGWHIGIKVLAVGEVDLVARRSEVADALAAEGIDANVVEQADGWA AWTTLPGEPRPEAITRIAECIRAAQARLEPTMETWVGVGRAHDGPAGIGSSLSEAGDAA RLAGSRSQTGRFLHVDRLGLAQLLLAWTRTDTFQPAAAALLAPLRDSNGELLETLSTYL DEESSLAHTATRMGLHRNTVSSRIDRIQRLLSVDLADPETRLALHLACRTIAP" regulatory 27976..28090 /bound_moiety="S-adenosylmethionine" /db_xref="RFAM:RF00634" /inference="COORDINATES: nucleotide motif:Rfam:14.4:RF00634" /inference="COORDINATES: profile:INFERNAL:1.1.5" /note="SAM riboswitch class IV; Derived by automated computational analysis using gene prediction method: cmsearch." /regulatory_class="riboswitch" gene 28144..29469 /locus_tag="PXH69_RS00115" /old_locus_tag="PXH69_00115" CDS 28144..29469 /NRPS_PKS="Domain: Aminotran_5 (36-395). E-value: 2.1e-90. Score: 295.2. Matches aSDomain: nrpspksdomains_PXH69_RS00115_Aminotran_5.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_5" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1139: aminotransferase class V" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746685.1" /locus_tag="PXH69_RS00115" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00115" /product="aminotransferase class V-fold PLP-dependent enzyme" /protein_id="WP_054187865.1" /sec_met_domain="Aminotran_5 (E-value: 5.4e-89, bitscore: 294.0, seeds: 34, tool: rule-based-clusters)" /sec_met_domain="Aminotran_1_2 (E-value: 1.4e-06, bitscore: 23.0, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MTAVLSADTCCTTAIAKVSGSDLQVPLVQGGECSYANFDYAASAP ALAQVTDRIAELLPTYASVHRGAGYASRISTLTYENARESVARFVNCADDQVVVFTRNT TDSLNLLAQCVPGSTVVLDVEHHANLLPWNDARIVTAADTIEETIERLIGELCTKPAAL LAITGASNVTGEILPIARLADIAHRCGARILVDAAQLAPHRRIDLQECGVDYVAFSGHK LYAPFGAGVLVGRRDWLDEAQPYLAGGGAVREVTVESTEWACAPARHEAGSPNVLGAAA IATACETLHALDFDVIAEHEKALTAQLTDGLSAIEGVSLVRLWNDAPDAVGIVTFTVDG FEAGEIAAFLSAEHGIGVRDGRFCAHPVLARLGLSGGAVRASLGLGSSSDDVTRLVDAV NILVSNQRDWKYAKTAGAWNPVPETRPFLGAADDNAGAAECV" aSDomain 28252..29328 /aSDomain="Aminotran_5" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_PXH69_RS00115_Aminotran_5.1" /evalue="2.10E-90" /label="PXH69_RS00115_Aminotran_5.1" /locus_tag="PXH69_RS00115" /protein_end="395" /protein_start="36" /score="295.2" /tool="antismash" /translation="NFDYAASAPALAQVTDRIAELLPTYASVHRGAGYASRISTLTYEN ARESVARFVNCADDQVVVFTRNTTDSLNLLAQCVPGSTVVLDVEHHANLLPWNDARIVT AADTIEETIERLIGELCTKPAALLAITGASNVTGEILPIARLADIAHRCGARILVDAAQ LAPHRRIDLQECGVDYVAFSGHKLYAPFGAGVLVGRRDWLDEAQPYLAGGGAVREVTVE STEWACAPARHEAGSPNVLGAAAIATACETLHALDFDVIAEHEKALTAQLTDGLSAIEG VSLVRLWNDAPDAVGIVTFTVDGFEAGEIAAFLSAEHGIGVRDGRFCAHPVLARLGLSG GAVRASLGLGSSSDDVTRL" misc_feature 29617..29637 /note="TFBS match to NrtR, NAD synthesis repressor, confidence: weak, score: 20.77" /tool="antismash" gene 29680..30294 /locus_tag="PXH69_RS00120" /old_locus_tag="PXH69_00120" CDS 29680..30294 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019746686.1" /locus_tag="PXH69_RS00120" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00120" /product="hypothetical protein" /protein_id="WP_054187866.1" /transl_table=11 /translation="MSSLASHSLHVAVELTGSGHHPAAEGAPGNLPIIGGDYWVDLTEG EKALDLASFPTNVVRIRAADLREAQLERARIRAAVAEEGRDPDSVAVLVDLEILIAPEA RSARKELAQLDSALTSPRVPVSLHYVGTPSGLGSLIADIRAAEVADGVTLLPLALPRAL EHLVDSTIPWLQDRGLVTPSTAVDEVLGRFGLPPRQRTLAS" gene complement(30273..31151) /locus_tag="PXH69_RS00125" /old_locus_tag="PXH69_00125" CDS complement(30273..31151) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007727134.1" /locus_tag="PXH69_RS00125" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="PXH69_00125" /product="DNA-binding transcriptional regulator" /protein_id="WP_054187927.1" /transl_table=11 /translation="MAMTDRDVDVPTRILIEGLLRTDGTVDGHTLYATADALGKTDQQV RLCIKRLVTEGKFTQEGRGRQATLRATPKALREMEPDVEFVRLAYRQDRDTVTPWDGYW HLAGFAIPESSRKGRDALRTRVVYLGGALVQGGLYVSPHAWEPYIRDAAAELDVEQHLS SLTTRDLKVGTLEDPVKIAAQLWPLDQIADGYERLLDVATARLHKLQNSPGTDAVTMTI ELAAEFTRAMEPDPLLPPELLPTNWIGTRARSITAQCWTLLAQVDGADELPSLFHLYAD AIGDDQDASVR" misc_feature complement(31527..31545) /note="TFBS match to FuR_variant_2, Ferric Uptake Regulator, confidence: weak, score: 21.96" /tool="antismash" misc_feature complement(31528..31544) /note="TFBS match to NuR, Nickel-responsive regulator, confidence: weak, score: 21.5" /tool="antismash" ORIGIN 1 aacccggaag ctaagccctt cagcgccgat ggtactgcac tcgacagggt gtgggagagt 61 aggacaccgc cgaacacaca ttagagaagc cccccaacca gtgatggttg gggggctttc 121 tcgtacccaa aacaccccac cccaccacca ccatcacccg aaagtacctt cgccggcacc 181 cccgacttcg agcgaacggc actttcgtcg cctcagatcg acccaacgta ccgttcgcac 241 catcaagggg cgggagcacc cccgccggct cgccaccccg tccgggaccg agtgaacgac 301 acgctcaccc tcttaggcga ggggaacggt acgttcacac catcagggca gggcaggtga 361 gcggctgggc agatccgaca ggcgttatcg cagagctgcc tgtagcacct cgcagagcac 421 gtccagcgtc ctcgagtact gcgactgcat cggcgtgctg tagccgacga cgatgccgtc 481 accgccgact gacgacacgt cgggatgtcg gaagaccgaa agcccttcga gcccgagatc 541 gcgcgcccgg gccgctgcaa gaacagattg ttcggtgccg gagggcagac ggatcacagc 601 gtgaagtccc gcggagatcc cctcgaccct gacctggggt acttgctgcg caagtgtcgc 661 gaccagttga tcgcgtcgtc gtcggtacga ggtgcgcatc tttcgaatat ggctgtcgaa 721 tcttccggat tcgatgaagt ccgccaaggt caattgatcc gttgaactta cccagcgttc 781 gtagggtccc tttgttgcga ggacaggttc gatcagcctg tccggcaaca ccatccatcc 841 gatgcgaatg gccggcgaca gtgtcttgct gacagtgccc aggtacgcaa cgtgctgcgg 901 tgcgattcct tggagtgcac cgacaggttt tctgtcgtaa cggaattcgc cgtcgtagtc 961 gtcctcgatg atgacgccac ccgtagtcgt ggcccattcg agagcggtcg cgcgcctcgc 1021 cggtgtgagg ggaccgccga gagggaactg atgggtcggc gtcagcagaa cactctcagc 1081 agaagtagac gccaattcgt ctgtgcaagt gcctgattgg tcaaccgata tgggaactgt 1141 cagcagccct tcgtcggcga gcaactgccg gtgcaggtga aggcagaaag cgtcgaccgc 1201 aatcgttcct ccgagtgcgc gggcaaggag ggaaatcccg tgacccgagc tggcactgat 1261 cacaatgcag ctcggatcga cgcgaacgcc tctggtgcgg ctcaggtatg tggtgagggc 1321 gtttcggagt tcgactcggc ccctgggatc agtagtcgcg aacgcgtcgg tcggcgcggt 1381 ggtcaaagca cgtctggcgg acgaaatcca tgcagtgcgg ggaaacgccg acgcgtcggg 1441 cgatccgggg agaaggctgt aggtccagcg tcgtcgagtc ggtgatggct cgacctcgcg 1501 ggtgtgtgtg ctggcgagcg tggcgaccag ggtcccggaa ccaggccgtg tgacaagcca 1561 cccagctgcg gcgagctcgg catagcagtc cgcaacggtg tttcgggcaa ctccgaggtc 1621 gagcgcgagg gtgcgggaag gtgggagtct ggtgccgggc ttcaacagtc cactgtcgat 1681 cgcgtcgcga agggtctgaa gcagtgcagc gcgaaccccg attccctgtg gcagctcgat 1741 atgtagatcg aacccaagat tggcccacga attcaccacc ggattgaacc atgtttccgg 1801 gtctttccgg gattaccgtt tgagttatga ctacagcaac aggacaaaga ctggatatcg 1861 caaagctggc gcccgaggtc tacaaggcga tgattgcgtt ggatgccgct gcacgcaagg 1921 ggctggagcc gacgctcgtc gagctggtcc tcacgcgtgc gtcgcagctg aatcattgcg 1981 catggtgcct ggacatgcac actcgcgacg cccgaaaggt cggcgtcacg gagcagaagc 2041 tctacctact gaacgcgtgg gaagaagcgc gagggatgta ctccgatcgt gaacgagccg 2101 cgctcgcctt gaccgaggcc gtgacagtcc tcaccgacgg tttcgttccg gacgaggtgt 2161 acagcgaggc tgccggcgaa ttctcggacg tggaactggc tcagctcatc agcgtcattt 2221 tgacgatcaa tgcgtggaat cgcattgcgg ttaccacgag gaaggcgcct ccggtccgag 2281 actgatccga ggctcgtgct ccgctctccg gcagggcagg gcagggttcc gccgtcggag 2341 atctggataa tcgacgcaaa gaggaccaaa agattggttc aaggtgtgaa caaaaccaac 2401 agattctttg aatgtgaggc aaatcacata atgtgagtgg agattgttct ggggcatcta 2461 caagttgccc gaatcccgac aaagcagtct cggtcggaag tttccggcga aggggtccgc 2521 atagcgggcc ccttcttttg cgcgcgagct gaaaacgccc cttcctgtga gtttccccag 2581 aatgtccaag ttaccgactg gctagcgttg gcgaaatgtc gggaacgtcg cggttggatg 2641 agcagatttt ggggggatcg cgattgttgt gcggttggac aaaggttcag tcaccttcac 2701 ggctaactcg tcatccgaat gtccaagctg cgccctgagt gctcgacgat tgggtgatct 2761 ttcttgaaac atgcactaca ttgccattca gtaactggct gattgccata agtgatcggc 2821 tgatcctctc ggaagtgagc gctgggtggc gtggaattgg gaatccaggc aaccgtcccg 2881 ctaccgaaat gtcttgaaag ggaagctttg atgactgtgt ctggttcacg gcgtaggccg 2941 cttgttctcc ggctctcgct aactgcagct attgccgtaa cggtggccgg tagtagcgtc 3001 gcttttgctt cgccagctgt gtccgcgccg atgccggtgc gaaccgcggc cgctccggcg 3061 ttcaccgccg ggttgtgtga gggcaccgag tacacgccct cggagcagat gctcgacatc 3121 tccggcattc ggctggatca ctacaacgac ggcaacatcg tgccgatgta cggcaccacc 3181 gatcggggta cctcggccgc ggtggatgct ccggtctgcg gtgtccgcga cgtcgacgga 3241 attgcgaagt cggaatggat gtactgcacg gacttcgatc tcgatccgtg tgccggtgtc 3301 gacgagaacg gtttgccggt tgacaagcac aacgacgaga tgggtgcgac ggtgccgtct 3361 tcgggcaatc ccgatctgtc agccgacgat ctcgctgtca tcagttggtt gctgcagaat 3421 cccgccaaac tcgacggtgt cgtttcggga aatggcagcg aggatgcacg ttcggcgcgg 3481 cagacgcttg tgtggtgtgt ctcggactac gacaatccgc tgatggccga tttcaaaagc 3541 ctgtgcgaca ggaacatcgg tgacgacgag cgagctcgca tcgtcgagat catgaacgtc 3601 acgcagacgc tcgacctcgt tcgcaagaca cccgcgacgg ggactctgaa ggccggcgag 3661 actgccgttt tcaccctgaa tacgaatatg taccggaagc cgatcactgt tcagtcctcg 3721 gcgggcaccg aactgaccgt ctgtggtgac aacgccaagg cgacgttgac tgcaaatcaa 3781 ctgacggtcg acggccgcgg cgacgcaccg actgctgttg atctttgcct caccgctgcg 3841 gccggcgggg actactcggt gactgcaagc gtcattccgg attcggtcga gaacctgcac 3901 tggaacacgg caggcgcaca gtgccagatc ttcgcgtcgt tcgacaccgt tcggccggct 3961 tcgatgaatg catctgccag cgtcggatat gcagcagcac ccacgacgac accggcaacg 4021 agcacaccgg caacgagcac accggcaaca accacaccgg caacgaccac accggccacc 4081 acgacgcctg caaccccggt cgttccgatc gtgccgattg ttccgatcgt gcccatcgtg 4141 ccgattgtgc ctgtagttcc gggtgcacct gttccgtcgc agccggttgc aactcccgca 4201 actccggcgc cgtcggctcc gaagccggcc actggccccc gcccggttgc catcgacggt 4261 ggtgctgctg aacagaattc aggccgcaac gtcgccgtcg cagtgacggg cctcgggctt 4321 gtcggaatgg ctgctgccgg agcagttgct ctccgccgca agcgatcctg acaccaggca 4381 cgtgtagtag acgtcggcac cgatcacgct tcgtgtgatc ggtgccgaca ttgatcagac 4441 gcagggggcg tcaattcgca cgaggtgccg ggggcgcctc atccctcagg agacagttcg 4501 atgaccatgt acgagtcgga tcccaatcca tccaatccat acgacgatcc caaccacgat 4561 cagcccgcga gtccaggcaa agggcgtcgt gtcgcgttca ttctggctct catcgcggtg 4621 ttggtcgccg gtgcttccat ggccttcgtc ggcctgcgat cctccgatga cgatgctgcg 4681 atcccgccga gtccgggagt tgtcatgtcg cactccgcga atccggcagc gcctacggat 4741 gcgttgatga ctcccaacac tctttcgctc gacccggtcg gtgttcaggc gccgatcgtg 4801 gacgccaccg tgccggaagg agttctcact ccgccggaga acgtcaagaa cgtcggaatc 4861 tggctcgacg gtgcatctct cgattccgcc accggcacga ccttgattgc cggacacgtc 4921 aatctgaccg gccagggtaa cggcgcgctg ttcgacctgg gcacgatcga gccgggtgaa 4981 gtgatccgta catccgacgc gacgggtaag agcacgtcgt ggaaggtgac tgcggtgacg 5041 acgcgcccga aggccgatgg tgtggaggaa agcgtgctgg ccggcccgga aggccctcgt 5101 aagttggcag tcgtaacctg cggcggcgaa ctgcaattcg aggacggtgt gggcaactac 5161 gccgacaacg tctacctgta cgcggatctg atggtctgag acacaggaat gattccgacg 5221 gtccccgatc cctcttcgta gagatcgggg accgcctgtt ggatagtgtc gcaggtatgg 5281 atcttcacct gtctggaaag cgtgcgatcg ttgccggtgg tagcaagggg atcggtctgg 5341 caatcgccag aggtctggcc gctgaagggg tcgacatcgc gatactcgcg cgcactgagc 5401 gaaccgtcgt aagcgttcca cgagatttgg tttcggagtt cggaattcgt gcgatcggag 5461 tcgtgacgga tacgcgagac gacgacgcgg ttcaggcgtc ggtgcggcaa gtagtagagg 5521 agttcggcgg cgtcgacatt ctggtcaact ccgcagcgac tccgttcagc gccggaaagc 5581 cgacggattt cgaggcgacc acagacgacg tcgtgcgaga cgaagtcgaa gtgaaagtgc 5641 tcggctacct gcgcactgcg cgtgctgtag cgccgtatct gatcgatcag ggttggggtc 5701 ggatcatcaa catcagcggt ttgggtgcca gacaggccac ttcgatcgcc cacacgatcc 5761 gcaacgtcag tgtgtctgca ctgaccaaga atcttgcaga cgagctgggc cccaagggaa 5821 tcaacgtcac cgtcgtccat ccgggcgtga cgaggaccga gaggttgacc gcacggatta 5881 cgcgcgagtc ggaagaatcc ggccgctcgc aggcagaggt ggagcgtggt atcgcgacga 5941 actcgataca tcggatcatc gatgccgaag aagtagccga cgtcgtgacc ttcctggcat 6001 cgccgcgaag catcgcgatc accggtgacg cagtggcagc gggtggagga gtgccagggc 6061 cggtctacta ctgaaattgt gcgtactgct acctgccggc ggtggtgacg atcgtgtgaa 6121 cgcgtccgcc gccgagtctc ttgctttcgt acatcgccga atcggcgact ttctgcatgt 6181 ccgtgaacgc tgctgcgcgg tcttctccgg cgacgaattt gtgggtacgc acggcgattc 6241 cgatgctcga agtcgacggt atctcgtcgg aattcgagtg cattgccggt ccgatcgagt 6301 tgagcatcgg tccgatggct ggcacggaaa gtctttgaac gaggatgaat tcgtcgccgc 6361 cgacccgcgc gacgacagca tcagcgtgtg cccaggcgga taaccgctgc gatacccgga 6421 gaatgatgcg atcgccgacg tcgtggccgt gcacgtcgtt gatcgtcttg aaccggtcga 6481 tgtcgatcgc gatcacgagt agtgccgcag attcttgacg ctggaacccc tcgagtacct 6541 tctcgacgtg gcggtcgagg ccacgacggt tcaagaggcc ggtgagagga tcgaggtcgg 6601 aactggaagc atccatgctg agcatcgtca gcacgatctg cgagatgaat gcgcagacca 6661 ccaacgcggt gatgacgacc agtactttcg aaacaccaag ggctggatcg cgatccggcc 6721 cgaacagaat tggctgcgca gccaccgcga tcacaagaag cgagaaagct atgtgcgcga 6781 tctgcaactt cgggttgtgg aagtaggcga tgtagatgcc gaccagagca aaaatgacac 6841 aggtgagcaa tcgtgcgagc tgggaggaat ctccaacgac ggagatcgtg accgcgatgt 6901 cgcagaagac cacgaaaccg aacgagcgac gctttgtggg gccgaagacc caccatgaga 6961 ctccgactac gaagcacgag atcacgacag cagtattgaa gaacagcgca atcgtgcttg 7021 tcggaccggc agggctgaat ctgttcagta gtgcgcacac tcccagtccg atgacaatga 7081 tgccaagtaa tagccgggtg gcggtcgtga ggccgttgtc gcggagatag cgagtgaagc 7141 ggtcgtattg atcgggaaga atcaaccact cgcgggtcag cgtcctcatc gacttcatct 7201 gcgatgtcat gagtgcatca gtcctcgaag gctggagcgt gcgccattca tcgcgaactg 7261 attcctcttc tgtctggcac cttgcaatgc taactggatc gatgccgcat cggaccgaga 7321 tgttcggatc ggcgacccgg atgtctgcgt tgcgccagcg tggagtataa atacatcttg 7381 tgtctatgtt gtattccgct tccgaaaccg tcttccgcga agtcaaggag ctgatccttt 7441 ccggcgagct cgccggcggg gagctgatca gtgagggtga catcgctgca cggaccaatg 7501 tgagccgaac gccggtgcgt gaggcgtttc tgcgtctcga gtcggaaggt tggatgcgcc 7561 tctatccgaa gaagggggcg ctgatcgtcc cggtcgcgga tggggaagcg gaacacgtag 7621 tcagtgccag acagctcgtc gagactcaga gcgttcgagt ggtgtcggtc cgaccgcacg 7681 cacgggaagc gcttgtcgca gcgttgcgcg cgaatctgat cgagcaacgt gagattgctg 7741 atcgcgggga cgtggccgcg ttcagcgcaa tcgatgcaga cttccacaag atgatcgttg 7801 ccgccggcgg gaaccctttg ctcgactcgt tctacgcgag tctgcgcgac aggcaacgac 7861 ggatgacagc ccggtcgatc tcacgcgacc ccggccaact ctcgcgcatc cttgccgatc 7921 acaccgcgct taccgacctc gtcgacacag gcgatgccga cggatacaac actgccgtcc 7981 tcacacacat gcgccaggtc cacggcctcg gcttcgaagg aactctgtga tgagcaccca 8041 aacgatcggc gctgggaccg cggccgaaac tcgtctcgag ggtgaacgcc tctccggcgg 8101 aaagtggctg tggctgaccg ttgccgccag tatgttcgcc gctgcctggg gcggaaacga 8161 attcacccca ctgctggtga tgtaccgact cgaccacggc tattcgccgg tgatggtcga 8221 tttcttcctc ttcgcctacg tcgtcggaat tgtgccggcc ctgctgctcg gcggcccgct 8281 gtccgatcga ttgggtcgac gcccgatcat gctcccctcg ccgatcatcg cgatcgccgg 8341 ttcgacgctg ctcgctttcg gggcggactc cgccgctgct ctcatcctgg gaagaatcct 8401 ctgtggcatc gccttgggga tcggtatggc cgtcggcggc tcctgggtca aggagttgtc 8461 cacgcaacct tgggatccga cggcgtcgga aggcgcaggt gctcggcgag cagcgatgag 8521 tctgaccgcg ggcttcgcct tgggagcggg tgctgcggga atcttggcgc agtgggcgcc 8581 catgccgagt gtgttggcgt acgtgctgca catcgcgatc accgtcctcg ccgccatggc 8641 gctgtggcgt gcgcccgaaa cacgaccggc acaggcgaaa tccgaccgtc gcaggttgat 8701 cgacgacctc aagatcccct cggcaggtca ccgcagattc ctctacgtcg ttgttccgtt 8761 ggcgccgtgg gtgttcggtg ccgccagtgt cgcgtatgca gttattccgg cgctcatgac 8821 cgggcacagt ggcgatgcgc ccgtggcctt ttcggctctg ctgtgcatgg tcgcgctgac 8881 atgcggattc gcgattcagt cgttggggcg caaaatcgac accgaccgca gtgctcgtgg 8941 cgccgttgtg gctctggtgt ttctggtggt cggtatggcc ggtgctgctc tggttgcgtc 9001 gacgctgacc gtggcgatcg cgatcgtggc tgcagcgatc ctcggttgcg ggtacggcat 9061 ggcactggtg tccgggttgc tggagatcca gcgaatcgcg gggccggacg atctggcagg 9121 attgaccgcg gtgttctact cgatcaccta catcgggttc gcggtgcctg cgttgctggc 9181 gatgctgtcg gaaagcattc cggcactgag ctacacggtg actctgctgt tcggatcagc 9241 cgccgccgct gcctgcttga ttctgattct cttcaagtcg cgttcacacc tgccgagcgc 9301 gtgaagccgg tccgccgacc cctgcgagag tcggcggacc ggggcgaaat cacgcgtcta 9361 cagttgcgga accgttttcc gaactgtgga ccgaattgtg taccgaaccg gccggaaccg 9421 atgcggtctt gttcaggccg ttgagcaaac cggtgatatc gacgcctgag ctttcgagag 9481 tttcgatgac accggcaatc acctggggac tgatgcccag gatcgagccg atcgaaccct 9541 gcgccccgtc gctgccgccg acgatggaga tccgatcgat gtcgccgacc ggcttcgctg 9601 ctgctgcggt ggcgtcgacc agtgctgcca gaacgtcagg cagagtgagc aactgcgcgg 9661 cctgcggggt gtaggaattg agcgcctcgg cgatctgacg cttaccggca gcctcggctt 9721 cgagcttggc gcgcaaacca tccgcttcgg cctgctgttc ggcgcgaacg gcgtcggccg 9781 ctaccttgcg gccgtcagct tcggcttcca gacgtgctcg aaggccgtcg gcatcagcct 9841 gctgctcgga gcgaacagcg tcggcgacga gctttcgtgc atcggcctga gccccgccgg 9901 cctgccttgc tgactcggcc tgtgcctggg cgcggaggat cgcggcctgt cgctcaccct 9961 ctgcgcgtgc gatggaggct tggcgttcgg cctcggccgg tgcaatgaca tctgcctgca 10021 atgccgcttc cgattgctgg gcgcgacgac gctcgacctc ggtgcgagct tcgacgcggg 10081 ccgcctcggc ctgctcacgt gcgatgccga cggccttctc ggccgttgcc tgcgcgagtg 10141 gtccggcctg gtcggcttcg gcgttctcgg cttcggtctg tgctcgaagg cgagcgagtt 10201 cgacgtcgcg cttctgattt gcactcgcga tcgcagtgtc ggcctcggcc tgtgcgacgg 10261 agcctgcctg tcgcgccttt gccgactgga tctgcgaatc acgctctgct tcagcagttc 10321 cgatcgcggc atcacgtttg acctcggcga tgcggcgctg accgagcgat tcgaggtagc 10381 cgttgaagtc ggagattccc gcgatcttga tgacatcgac ttccatgccg atgcgtgcga 10441 ggtcgccgcc tgcctcctcg accacgctgc gtgcgagcga atcgcggttg gagttcagat 10501 cctcgaccgt catggttgcg gtgattccgc gcaggctgcc ggcgaggatt tcgttgatct 10561 gctgctggag ttcgtccagg tcggaggtca ggaatcgttg caccgctgtc tgaaccgctt 10621 cgtcggcgga accgattcgt accaggccga ctgcctcgac gttgaccgga acaccgtcgt 10681 tggagagcgc attcttgaga ttgatgctga cgttgaacgg ctcgagcgac atgatgtcga 10741 cgcgttcgat tcccggaatc ttgaaccggg ctccgccgcg gacgactttc ggcttgcctc 10801 gtccggtgaa gaccgccact tcgttcggcg ggaccttgac gtagttcttc acgtagatcg 10861 cggggagaac gatgaagatg attactgcga ctacaaccgc aatgatgatg attggcagca 10921 tgtatcgagt ccttagatcg cgtcgtcaac cgtgacgacg tgaaggtatt gatcgtctac 10981 atcggcgatg tagacggtgg tgccggtggt gagcgccatc ggctgtgcac tgacggcctt 11041 ggcctgcacg cgattgcctt cggcgtcgac gaacgagact tctccccaac cttcggctgc 11101 aatggtgagg gtgaccgtgc ccaacagccc ggagtacgaa gctcgtccga tgtgcgaatt 11161 atcttgttgc ttaatgagat aggggagaag taggccgcgc gtgacgacaa cgagaacggc 11221 ggcgagtgcg agtgctgcaa tcgccgctac caatgtcgga gcgtccgcga gagtggcagc 11281 tacgccgccg gcgccgaagc cgaaaagtgc tgtggccaag gttgtcaggc tcagaaatgg 11341 cagcccgtct gcgtggccgc cgcccagatc tgcaacctcg ccgacggcaa aggctccgat 11401 cagggcgacg accccgatta cgaaacatat tgtgaataca acgaacatcg atcccccgat 11461 ctacctgtcg aggaagcgtg ccctgagaat tgtgttgtcg gggtcgtccc tcggcccacc 11521 tctatagtaa aggtaagaca aagctaatcg gcgcattcgg aatgtttcgg cgtggtgata 11581 tcgcggtgag agagcgtcag agacgaggca gagagcgctg attcagccat gcatcccaca 11641 gtgggcgcaa tggagtgtcg gtgaaacgtg aagcgagatc ggtgaattgc tcggtactga 11701 ccgtgctgtg ccgatgcttc gtggtccact gacggatcag ttcgaagaac ttctcgtctc 11761 cgagaacgcc gcgcagggcg tgcagagtca atgcgccccg cttgtagatt cgatcgtcga 11821 acatcagggc aggaccggga ttggcgacga tcaagtcctg agatttacgc ccgagccctt 11881 gataggcgtt tgtcgcgagt tggttcgagg acggaccacc ggaattctcg gaccagatcc 11941 actccgcgta acaggcaaag ccttcgtgca gccagatgtc gcaccactgc ccgagagtga 12001 ggctgttgcc gaaccattga tgggcaagct cgtgtgcgac aagacgttcg gaaccgcgcc 12061 tgcctgtgca atggttggct ccgaagatcg agagtccctg cgcttcgatg gggatttcga 12121 gttcgtcgtc ggtgaccaca gcggtgtagt cggcaaaggg atacgggccg aacagctttc 12181 cgaagacctc cagcatctgg ggttggcgcc cgaagtcgac gtcgaacgct gcgcgcagcc 12241 gaggtgggtg aacggcgaag accggtaccg gcccggcgct cacttgtcgg tgctcgtact 12301 gaccgatctg aatggttgcc aggtaggttg ccatcggttc ggtctgctcg tagacccacg 12361 tcgtctgact cgcacgggtc tgcttgcgga tcagcttgcc gttggcgagg gcatagaacg 12421 gggaatcggt ggtgatcgag attcggtacg acgctttgga aatcggatgg tcgtcgcacg 12481 ggaaccagga cgccgcgccg ttgggctgac ttgcgaccaa agttccttcg tcgagttcct 12541 cccagccgac ttcgccccac aggctcttga tcggctcggg gttgccgctg tacgcgatgg 12601 tgaccgacag ggcaccgccc gcggggatct tggtagacgg cgtgaggatc agcttgttgt 12661 tcaagtgcgc gtacttggtg ccgcgggcac cgttgacgga caccttggac acctgcaggt 12721 tctgtgcgag gtcgaagctg aacttggatc ggctctcggt ggtgacagcg gtgatgacag 12781 ctttgccggc gagacggttg ctgaagacct tgtacgtcag ttccagttcg taccgggaca 12841 cgcggtaccc gcggttgccg ttgagcggca ggtacggatc gatcggctcc tcgagcattc 12901 ggttcggctt cacgacgcca cccacggtgc aatcgggttg ccctgccagc gggtggaggg 12961 cggaacggtg tcacctcgca tcaccagaga tgcaggccct accgtcgctc ccgcgccgat 13021 gccggctgcg ggtagcgcga cacagtgcgg tcccagcgtt gctcctgctc ccaaagtgac 13081 ggtgtccatg gacatgatcc gatcatggaa gagatgagtt tgcacgacgc acccccgttc 13141 cactgtcgct ccgtcgccca aagtcacaag atctgcctcg ggtagccagt acgactcaca 13201 ccaaacgccc ttaccgatct tggccccgag tccacgcaag aagatgttca gtacggccgt 13261 accagtcgcc gcgcgagcga accacggcgc cgcgacggtc tcgacgaagg cgtcggctac 13321 ctcgtttcgc caaacgaacg aactccacag cggatgctcg accttggcga tgcgtccgac 13381 gacgatccac ttggcggcga tggtgatcgc gcccgccact gctccggcga cgagcagaat 13441 tacgccgctc agcagagccg cgaaccagaa tccgactgcg ccgaccagtg cttcgagtgc 13501 aaacagaaca ccgagaccga tgccgaacgt gaccatgacg gggatcagtc ggcaggtttc 13561 gaccactccg cgggcgatct tgaggcgcat gggcggattg aacgtgcggg cggcgtcggt 13621 gtctccggca gcccttctca gacgtaccgg tggactaccc agccacgatg atccggactt 13681 ggccttggac ggggtagccg acagaaccgc caccagaccg ttcttgggga cgcgtcgacc 13741 gggggcggtc ataccggagt tgccgaggaa cgcgcgcttg ccgatcttcg cctgttcgat 13801 gtgcatccag ccgccgccga ggccgtagct cgcaaccatg gtgtcgtcag cgaggaatgc 13861 accgtcggcg accgtcgtga acttgggaag gaggagcacg gtggatgctt cgacgttctt 13921 gccgatcttg gcgccgagaa ggcggagcca tcccggcgtc agcaggctcg cgtagagcgg 13981 gaagaggaag gttctggccg agtcgagcag gcgttcggtc gcccacacct gccagccgat 14041 gcggctgcgg acagggtggt aaccgggggt cagcccgatc gagagaagac gaacggccac 14101 aagggtgacg actgcgaaga cgagcaaact caggatggtc gcgacgggaa gcatgatcag 14161 cgattggagc actgcgctcg cgagcgtgtc ggtgtcgcga atccaccaac cgatcaatgc 14221 gatcccggcc atcagcgcga agatcggcat accggccagg aagaccgagg tgacgccgta 14281 taccggcacc cagccgggtg cacgcttcgg atgttcggca ggccaaggat gattcgcttt 14341 cccgaccttg gtggcggggg agccggccca ctgctggttt gccttcactc ggccgaacac 14401 cgcagatccg ggttcgacga cggcgtcgcg accgatacgc gcgccgggca gaagcgtcga 14461 gcgtgaaccg acggaggcgc cgtcaccgat cttgatctcg ccgatgtgaa tgacgtcgcc 14521 gtcgatccag tggccggaga ggtcgacttc gggttcgacg gagcagccgt caccgagttc 14581 gagcatgccg gtgatgggag gaagggtgtg gagatcgacg ccgctgccga tgtcggcgcc 14641 gagggcgcgg gcgtagtaga gcatccacgg tgcgcccgaa aggttggctg cgccactggc 14701 ttcggtgagt cgcagcgcta tccacagacg caggtgttca ctaccgcctc ggggatacgt 14761 gcccggttcc agcttgcgca ggagcaggcg cgctccgacg acagcgatgg tcatgcgccc 14821 gatcggcgtg atgaacacga tgaatgccaa caggatccac caccacgaga ccgtgggcgc 14881 ccagctgacg tcgacgaacc agccgaggac gttgttcgcg atcgccagcc acgtcaccca 14941 ctgcagtccg gtgagcgtcg tgagcggaac ggtgacggcg atctgcgcga gctgagtctt 15001 gaagggtgtc ggagcgacga tgcgcggctc cacagtttcg gtgggtgcca attcgtcgag 15061 atattcggcg agcgatccca accgtgggtg gtcgtagagc tgtgcgacgg tcacttcggg 15121 gaaccgctcg cgcagggcgg ttaccagctg agccgcagag agggatccgc cgcccacttc 15181 gaagaagtcg tcgtcgagtc cggtgatctg cgcgcccagg atcgaacccc acagaccggc 15241 aacccaggca gcggtgccgt cgaggcccaa cgcggccccc gcatcttcac cggcgccggg 15301 caacggccac ggcagcgcat tgcggtcgac cttgcctgac gtacgcgtcg gaagttcgtc 15361 catcaacgcc agacgcggca cgagggccgc tggtagttgc tcgctgagca gcgcatgagc 15421 ggccttgaga tcgaagtcgg gatccgtgct ggcgatgtat ccgacgagga gctggttgcc 15481 ggctgccgtc ttcttcacgg ctgcggcagc gccgctcaca cccggcaggt tctgcaaggc 15541 gttgtcgacc tcaccgagtt cgatgcgcct gccgccgagc ttgacctgat cgtccgcgcg 15601 gccctggaac atcaggccgg tggtctcgag ccggaccagg tcgccgcttc ggtaggcgcg 15661 atcccacccg agcgagggca tcgacgcgta cttctcggcg tccttcgcgg gatcgaggta 15721 acgggcgagg ccgacgccgc cgatcaccag ctcgcccacc tcaccgaccg cgacgggatt 15781 gctctgggcg tcgacgacgg caaggtccca gccgtcgagg gggaggccga tgctgacggg 15841 gctcttgccg tccatcagtg cgccgcaggc gacgacggtt gcctcggtgg ggccgtaagt 15901 gttccagacc tcgcggccct cgacggccag gcgctctgcc agttcgggtg ggcaggcttc 15961 gccgccgaag atcaggagtc gaacggcttc gagggcctcg gccggccaca gagacgcaag 16021 cgtcggcaca gtggagacga tgctgacgtc acgcgagacc agccacgggc cgaggtccat 16081 gccgctgcga accagtgaac gaggcgccgg gacgaggcag gcgccgtgac gccacgcgag 16141 ccacatctcc tcgcaggacg cgtcgaatgc cacggagagt cccgcgagga cgcggtcacc 16201 aggcccgatg ggctcgtcct ggaggaacat gcgcgcctcg gcgtcgacga acgccgcggc 16261 attgaggtga gtgaccgcga cgcccttggg ggtgcccgtg gatcctgagg tgaagatgat 16321 ccaggcgtcg tcctcgggtt cgggttcgcg aaccggtgga tgttcgagcc gcttcggcgc 16381 cgtccccggc tggattccgt cgccggtgat gatcgccgct acctgcgcct cgccgaacac 16441 caactcggcg cgctcttccg gatcgtcggc gtcgacggga acgtaggcgg cgcccgccgc 16501 gaggatcgac aggatcgcca cgtacagcga acgcgaacct gacggcatcc tgattccgac 16561 gcggtcacct gcgccgacgc cggcatcacc gagccagcgc gcaccgagcg cgatctcgtc 16621 gagcaactcc gagtacgaca gtgtggtgtc gccgtcgtcg atggcaggtg cttccgggtt 16681 ggcctcggct gaggcccgca cgatgtcgat gagcgtgcgc ggcgcaggtg catgcgccga 16741 ccgtaggaat acggacggaa tcccgaaaga ttgttccgtc tccgactgcg actggagtgg 16801 caaacccgtt ggtcctgttc tactcacgaa acttagagtc ctgcgaactg tcgagttgaa 16861 agtctcatga caagtttgcg agttggtgaa cagatatgcc taatgcaaca tgccgaacgt 16921 gccggtcagt ccgtactggc agcttgcgcg tggccttctg ccgagtcggc gaactcgggt 16981 gtgtcgaaca cctctccgcc cagcggatcg acgaccttcg attcctcgga gaagtcgacg 17041 gcgccggtat ccgggtcgat gttgaccgca tgggcgggaa cttcgtggac cgcgacgagc 17101 atgtgggcgt cggagggatc cgtcatgatc ccgctttgtg acggagtgag cccggcgaag 17161 gtcgacgaga tcttcagatc gcggagccgc ttttcggtgg gttgcggaac gtcggtcgat 17221 gccgaggtat ttgtagaaac ccgcagatag cgtggtgccg acgcgacctc gtatcggaac 17281 gccttcagca tcgacagaca tgccagcacc atgatgaccg agaacggtac cgccgtggcg 17341 atggcaacgg tttgcagcgc cgtgagcgat ccactgccac ccacgatgag gagaactgcg 17401 gccgcggcac cggagaggaa cgtccagtag acacgcgtga tcttggaggt ctccaagctg 17461 ccaccggtcg caaggatgtc gatgacgatc gagccggaat ccgcggacgt gacgaagaag 17521 aagacgatca cgacgatcgc gagaacactc gaaatcgttc cgagcggaag tccgtcgaga 17581 agcgtgaaca gcgacgtgtt ggtgtccact gcgccggatg cgtcgagcat cgtgccctcg 17641 ttgcgctgac gcagaatgcc ggagttaccg aagatcgtga accacaacga accaaccagc 17701 gtcggggcca gcagcacacc gaagacgaat tcgcggatgg tgcggccgcg tgagatgcgc 17761 gcgatgaaca tgccgacgaa cggtgcccaa ctcatccacc aaccccagta gaagatggtc 17821 catgcaccct gccagccgtc ttcggcgaac ggggacgtgc gcagcatcag ctcgggcaag 17881 gcctggacgt atccgccgag gttctgcacc cacgactgca tcaggaacaa tgtcggtcct 17941 agaatcagga cgaacagggc cagcgcggca gcaagcatca tgttgatgtt ggagagccac 18001 ttgaggccct tcgtgacgcc ggagacgacc gagaaggtgg ccatgcccgt cacgatgacg 18061 atgatggtga tgaccaacca gttgtcggtc tccacccagc cgaggtagtc gaggccggcc 18121 gagatctgct ggacaccgaa gcccagcgac gtcgcgacac cgaacagcgt gccgacgatg 18181 gcgacgacgt cgatggcgtg gccgatcttt ccttcgatgc gagcccgtcc gaggagcggc 18241 tcgagcaacc aacggatcga gagcggacga cccttgcggt aggtcatgta cgccagacca 18301 aggccgacga cgacgtagat cgcccatgca tgaaggcccc agtggaacag cgtcagttcc 18361 attgcttgat tggctgcggc gtccgtggat ccggcgatct gcccggcgac gggtggggtc 18421 acgtagtgcg aaagtggttc ggctactccg tagaacacga gcccgatgcc catgccggcg 18481 ctgaagagca tcgcgaacca cgagagcatc ccgaactcgg gctgctcgtc gtcacgtccc 18541 aatcggatgt tgccgatgcg gctgattccg cagtacagcg caaaaatgac gaaaccggtg 18601 gccgagagga tgtaccacca gccgacgccg tcgctgatca cgttgttgag tgtttcgaaa 18661 gcgtccgcgg ctgttcccgc gtagatcacg gcaaaggcga tcagggcaaa gatcactatc 18721 gacgcgggga tgaacacggg tttccgtagt tcacgccacg cagttttgac cgcagtcatt 18781 ccactcctcg aacgttcagg cattcacagc gcccatacgg gcagccacgt gtcacgcgta 18841 ggtgggcgtt gcgctcacac catcgcaggt caagaccggg ctattgcttt gaaattcaac 18901 gtaacgtcaa gtttcggtca actcaactgg acgaaagatg ctgcactgtc gcgaaagttc 18961 tcactggata ccgtagttcc ggttgtaaat cattgggtaa tagtggcatt gggccatgag 19021 tggaatgctg aacggcgaat tcgattggta cggtgagttg aatcggtcga gtcgacgctc 19081 accgattgac cacatttgtc aaactcggcg aaacagcctg tctgtcaggt ggttaactcc 19141 tggtgtgctt gcccgatcgt ggcggtcagg tgtcgatacc taactgtaat tgtgatggtc 19201 gcaactatca gtgatgcggg ccctgttcgc cccgctgagc gtcgatcaga tccatcgcat 19261 ccttcagacc gaagcccgga tgcagttcgc gtagtgcctt gattgccgga atgcggtcgt 19321 cagtcgacgc gagtgcgcta cggacgtcgt cggcgggtat ttcggtgggg gcagttgtcc 19381 cttcccacca caccgactga ggtttgttcc tgtttcgcca ggcttggacg gtgccgtagg 19441 caaatccggc cgtcgcgaaa agccagattg ccaggcgaac ccaattaccg gttgtcggtt 19501 ccgtggtcac tgtatggatg gtgctcggac cgattacgac tacgagcagg acgaggccaa 19561 tcgtctgcca ccatcgctcg acgcgcctgc tcggattcca ccactcggcc atcgatcgat 19621 actcgcacag tgctgcggtt tcgatgcgac gatggagatc atggagattc gtgatgcggt 19681 ggagcgattt cgaggggaat cagggacctc gacgatcttc ggagaaccgc accagaccag 19741 cgacggatcg acgatcatca cggtttcgcg tctacaccgg cggtggcgcc gcgacccgat 19801 accggtgcca gtgggagtgt tctcgatcca cgagggtgag ccgtcgtggt caccggccgt 19861 cgatcacacc agggcggctt tgatggggga gttcatcggg ttggcagccg cagtgatcgc 19921 aactctggcc gttctacgtc gtccgccctg gcctgatgtg acgattcaga aggggtgacc 19981 cagaattacg ccgatcagtt ggaacggcat cgcgaggaac atcgatccga cgtagagcgg 20041 atagcgaatc ggatcgccgg cgaggtaacc ctcggcgagc caggccatga cgtctgctga 20101 tcccatagtc gttacttccc ttcgctgttg tggttcaccg acattttcgg tcgtgggagt 20161 tgttttgtta caggcgaact cgaaggagga gtacatgtga aggcagtttc gacgcagcaa 20221 acgtcgtcaa gcgagatccc cgggggcggt gtcctctaac agctaagtct cgatacttag 20281 cactgtgccg tagtgaaatc tgtgcgttct gcacatgtcg ggacaattcg gtgagcccta 20341 cagtcgctgc atgacaacga caccttctcc tctctcaggc aagaccgtcg tactgatcgg 20401 cggcggaaca ggcatcgggc tgcgagtggc gcagcttgcc gtcgacgccg gtgcgcaggt 20461 agttctcggc ggccgaaccg catccaagct cgaagcagcg gccgcgcagc tgggtgaggc 20521 ggcgcactgg ttcaccgtcg acacctccga cgacgactcg gtgaaagcgt tcttcaccaa 20581 catccccagc gtcgatgcgc tcttcaccac ggctgccgat taccaggtcg gctcgttccg 20641 tgaacagagc gtcgaggaag cggcgtcgcc gttcacctcc aagttctggg ggcagtaccg 20701 cgtcgtgcac gctgcgctcg acaagctgac acccaccgca tcggtggtcc tcatgtccgg 20761 cgctgccagt gtgcggccac ccgcagctgc cgcggcatac gttgcagcca acgcggcaat 20821 cgaggggctc gggcgggggc tggcggtcga actgtcgccg atccgcgtca acactgtcgc 20881 tcccggaacc atcgacgggc atctgtgggc tcagcgcccg gcggaggttc gggaggccgc 20941 gttcacctgg agtgccgaga acaacgtgct cggccgcgtc gggaacgaag acgagattgc 21001 acaagcggtg ttctatctct tcaccaacac gtacacaacg ggttccacgc tgtaccccga 21061 cggcgggtac gcgttgcgtt agacccgtgc catttggcga ctgtgtgaaa tgacgactgt 21121 gcgaaatgca ttgtcgtaac acgaagaaac gccaattcgc ccataggcgt gacccctgcc 21181 acattcgtac cgtcttctcc gagaacactt cccaactatt cgaggagtcc gtcatgaaaa 21241 acacgtcagc gaccgccgcc ggcggtgaag tgtccgacgg tgacgactac gcgctcaccc 21301 gcgttcccga cgaagcacga tattcgtggt tctcggtggc agtacagcga ttcggtcagg 21361 tatcggcact cgcacagttc ttgctcggtg cgacgctcgg ctacggtatg acgttctgga 21421 atgccttctg ggcattgaca gtcggggcgg tgattctcga ggtcgtctgt attttcatcg 21481 gcatcatcgg ggttcgtgaa gggctcaaca catcggtggt cgcacgctgg tgtggattcg 21541 ggcacgcagg ttccgcggtg atcggtttgg tgatcggggt cagcctgatc ggttggttcg 21601 gcattcaatc tgctgtctct gcatcaggtt tgcacggaat catgccgttt ctgccgcagt 21661 gggcgtgggc tttggccttc ggtctcctga ttaccgcgat agtccttcgc gggttcggat 21721 ccatgcaact gatcgccaac atcaccgttc cgctgttcct gatcctggtc ggttgggccg 21781 tcgtcgccga actgcgtaat cactcgctgt cagatctgat gacatctgct ccagccgggc 21841 cggagctcag cttcctcgcc ggaactacca tcgtcgcagg cggtttcatt gccggagcag 21901 tgatcacacc tgacatgacg cgcttcaacc gcacggcagg cgatgtcgtg aagcagacgc 21961 tcgtcggaat aacgttgggc gaatacgtga tcgggctgac cggtgttctt cttgcccatg 22021 ccgttcgcag ttccgacatc gccacgatca ttctctcgtc ggtcggttgg gtcggcgttc 22081 tgatcatcgt tctcggcacc ttcaagatca acgactggaa cctgtacagc tcggggctcg 22141 gcgtcgtgaa cttcatcgac gtcgtgttcg gtcgacggat caatcgcgcc gtcgtcaccg 22201 ctgtggtcgg catcaccggt tcggtcctcg cggctgccgg aatcctcaac tcgttcaccg 22261 acttcctgat cctgttgggc gtcggattcc cgccgatcgc cgggatcatg gtggcggaat 22321 acttcatcgt caagacatgg cgcaaggatc tggaggagag tcgagctgcg ggtaccctcc 22381 cgaactcggc acccacttgg gtaccggcca cgctggtgat ctggatcgtc tcggcgctga 22441 tcggtcatta cagcaccttc ggcctgccgt cgatcaacgc ggtggcctcg gccttcgttc 22501 tctacgtcgt cgcgggtcga ctcggcctga ttcgcggagt cggacgcacc gccaccgaag 22561 cgccgcaaga gacttcggga aaatctgcgc tcacgcacta gcacggcaca cactgtagaa 22621 gggagttcgc gatgcgaatc ggaatcgacg tcggtggtac gaacaccgat gcggtcctga 22681 tggacgggac caccgtcatc gggcatgtca aacactcgac cagcaaggac atcaccggcg 22741 gaatcggcgg agctctgacg gcgctgcagc agcagtactc gttctctccc agcgctgttc 22801 aagcagtgat gatcggcacg acgcactttc tcaacgctct catcgagcaa cgcggacttg 22861 caccgacagc ggctctgcga ttggggcttc cggcgaccgc ggcgcttccg ccgatggtgg 22921 ggtggccgcg agacctggtc tccgctgtgc aaggaaggcg ctacctcgct cacggtgggc 22981 acgagttcga cggtcgtcgt atttcgtcgc tggaccccga cgagattcgc cgccatgccg 23041 ccgccatggc tcgcagcggt actcgttcgg tcgcaatatc ttcggtgttc tctccggtca 23101 atctcgaatg cgaagcggcc gccgcggaga tcgtgcgtga ggaactcggc ctcgacgtcg 23161 caatttcgct ctcgcacgag atcggtcgag tgggtctact ccagcgggag aacgcgacca 23221 tcatcaatgc tgcgctgcgc gagctcgccg atcacatcgt cgacggtctt gcccgatctt 23281 tggtcgagca cggcattgtc gcgccgctgt acctgagcca gaacgacgga accttgatgg 23341 acatcgagta cgcaaggcgt tatccggtgg cgactttcgc atcgggaccg accaactcca 23401 tgcgaggcgc cgctgtgctg tccggtctgg ccagctgtgc ggtgatcgac atcggaggta 23461 ccactaccga cgtgggcgta ttgaccaacg gtttcccgcg agaagccacc acggaggtga 23521 cggtcgcggg ggtacggacc aatttccgta tgccggacgt cttctcgatc ggtatcggtg 23581 gtggttcgct ggtggatgca gacggactca cagtcggacc cgaatctgtg ggatacgaat 23641 tgggttcacg ggcactcgta ttcggcggtg acacgttgac ggccaccgac atagccgtcg 23701 cggcaggctt ggccgacgtc ggagatcgca gtgcggtggc gcacctcgac cgcggcctgg 23761 tgtcgacggc actcgaccgg atctcgcgcc gagtcgccga cgccgtggaa cagatgcgga 23821 ccacgtcgga tccacttccc gttgtggcgg ttggcggggg atcggtactg ctggagcgtg 23881 aactcccggg cctgggaatg gtgattcgtc ctgagcgctt cgatgttgcc aatgcgatcg 23941 gcgctgcgat cgcgcaggtc agtggtgagg tagatcgagt cgaagcggtg cgggacgggc 24001 accggcaggt ttttgccgac gatgctcgcc aggaggcgat cgatcgggca gtcgcagcag 24061 gcgcacggcc cgagtcggtg cagatcgtgg agttcgacga ggtcccgatt ccgtatctgc 24121 cgggcaacgc aacgcgtatt cgagtgaagg cagtcggtga cttggcactg cacagtggtt 24181 tggtctccat cggtcaggag ggctcacgat gagttggaca ctacgaacgg cggacctcga 24241 cgacctcgcc aggggcgcag ccttgttggg caccggcggc gggggagatc cgttcgtcgg 24301 caagatgttg gtcacgcagg cgctcggtga ggccggtgaa atcacaattc tcgatccgga 24361 ggagcttgac gacgacgcat gggtgattcc cgtcgcgcag atgggtgccc cgaccgtcgt 24421 ggtcgagaag atgccgcgcg gaaccgaacc cgagctggcg ctgatcacgt tggagaagca 24481 cacgggtcga actgcagatg ccacgatgcc gatggagtgc ggcggaatca attcgatgat 24541 tccgttgctg gtggccgcgc ggcgcggcct gccggttgtc gacgccgacg ggatgggacg 24601 agcctttcct cagctcgaga tggaaacctt ctcggtgtac gggatttcgg cgagtccgct 24661 cgccatggcg aacgagcacg acgaggtggc gatcttcgac accggaagtg acaacagcag 24721 attggagggc ctcgcccgcg gggtgacgtc gaggttcggt gggatggcgc acatcgcgca 24781 gtactcgatg acgggtgcag atgtgaagcg gacggcgatc ccacggactc tgtcgttggc 24841 catgaccatc ggccggtcca tcagactttc acgtgagcag cgggtggacc cggtgcaggc 24901 gcttgtcgac agtctcgccg acacgctcta cggatacggg cgagttctct ttcacggcaa 24961 ggttatcgat gtcgacaggc gaaccgatga ggggttcgct cgcggttcgg tgcggatcgc 25021 cggcgtcgga gacgaagagc tggaagttca gttccagaac gaaaatctga tcgccgtcca 25081 atccggagtg atggtggcga tcgtgccaga cctgatctgc atcgtcgagg ccgataccgc 25141 cgaacccatc accaccgagg gcttgcggta cgggcagcgc gttgcggtca tcgggatcgc 25201 gaccccaccc atcatgagaa ccccggaggc actggcggtc ttcggcccgg ctagcttcgg 25261 gctcgatcgc ccgttcctgc cggtggagac actcgagcaa cctgtactgg cagaatagcg 25321 agccgtgagc aggctgcacg cggtccggga ggccgacctc gacgcgatcg cagcgggggc 25381 ggtggtcctg ggctgcggcg ggggcggcga tccacgcttg ttcgtggaat tgctgcgtcc 25441 actgatgacg tctacttcgg tggaggtcat cgcgccggac cagttgccgg aggaggcatt 25501 ggtgatgccg gtgggaatcg tcggatcggc cctggccttg gaggagcaat tgccctccgg 25561 gcgtgagttt gcagatactg cagcagcttt gacgcgctgg accgggaagc gtccgaccgc 25621 ggtgatgact ttcgaaggcg gtggactcaa cgctctctcc ggcattgcgg cggcgttggc 25681 gttgggaatt cccgtggtcg acgcggacct gctgggtcga gcgatgccgc ggctcgatca 25741 cttctctctc gccgcagccg ggttggaatt gtgcccggtc acactcgccc agcccggcgg 25801 cctcattacc gtcgtcgacg gagtggatgt actcggcgcc gaggtagcag tgcggtcgtt 25861 gatcgggaga accagcggtt ggggcgctct agcgatcgcg tcgatcgatg cgcggacggt 25921 gcaggaggcg tgcattccgg gaactctctc ccgagcacac gaactgggtc agcacatcgg 25981 ggccctgggc agttggcagg agatcgcgga gagctccggg gccctggtaa tggggactgg 26041 ccgggtgcgt gcggtccgtc gtagtcgtcc ggacaccggc gatcgtcggg gcagcgtgat 26101 tctcgaacac gattctgcgg tgatacgagt cgaattcgag agtgagttcc tgaccgtcgc 26161 gttggacggc gagatgattg caacgtgccc ggacatcgtg acgttgctcg acgtgcggac 26221 cggcgccttc gtctcgtgtg aatccgtgca ccaggggcac gatgtggccg tgttggttct 26281 tcccggtcca cagtggtggg cggacgaagt gggcagattg aaagttgtcg gcccgcgggc 26341 attcgggatc gaccacgacg cagtgctgat ggaggcgcga tgagcgcgag tgtttcggcg 26401 ttgctgaaca acccggcctt tgtcgggctg tatcgacttg ccggggaggg tgatcccgtc 26461 gtgacgacag tgggagcact caccggggaa tcggcacagt cggccgaggc cgtgtcgggt 26521 gcggcgagtt caggatcagt tctggtgatt ctcgatcgaa tcgacatcgg ggagtggaga 26581 ttcgacgctc tccttcggcg cacagcggcg accggctgcc aggtggtcgc tgtgcacagc 26641 gctgcggcgg aggatgcgaa tctctcgttg cttgccgatc ggctcggact ggtggtgctc 26701 ggagtatccg acccgtggca gttcagcgtg gatcttcgtg atcttctctc gaattcgcgg 26761 gcggtgatgg ccgacgcagt actgcgggcg acacacgcgg gccaacgagc cggaggaagc 26821 gtcgagaatc ttctgtcggt gctactgaac acctttcagc gttcattctt tctcctggac 26881 acgtccggac gtccgatgac cggcgccgac ctgttgtcag acgctgatcg agcagctgcc 26941 ggtatgttgt cgggtcgcgg ggcgcccacc acggtcgaat tggactccgg cggggtcctg 27001 attgcgtgcc cggtgatgtc cggcgcagcc cgagagccct ggctggcggt gctgctcccg 27061 gtgcgtcaaa gcgtcgaaga ggcttctctc tcagtggttc tcgacgtggc ctcgttggct 27121 gccgggcacc gactggccgt tgcgcgcatg gtcgacgagc gtgaagcgcg ccggcgtagc 27181 gcgttgctcg gtgaactgat cgacacgtca gcagacgcca cacccggact gctccggcgc 27241 gcactcgacg cgggttggat gctggacgga tggcacatcg gcatcaaagt cctggcggtc 27301 ggtgaggtcg acctggtggc aagacgcagc gaggttgcag atgctctcgc cgccgaggga 27361 atcgacgcca atgtcgtgga acaggctgac ggctgggcgg cgtggacgac tctgccaggc 27421 gagccgcgac cggaggcgat caccaggatc gccgagtgta tccgtgcagc tcaggccagg 27481 ttggaaccca cgatggagac ctgggtaggt gtgggacgcg cacacgacgg tccggctgga 27541 atcggttcgt ccctgtcgga ggccggggat gcagctcggc tcgccggttc ccgatctcaa 27601 acaggtcgat tcctgcacgt ggaccgcctc gggctggcgc agttgctgct ggcgtggacg 27661 cgaaccgaca ccttccagcc tgcggccgcc gcattgctcg caccgctacg cgattccaat 27721 ggagagttgc tcgagactct gtcgacgtac ctcgacgaag aatcgtctct ggctcacacc 27781 gcaacccgaa tggggttgca ccgcaacacc gtatcgagtc ggatcgatag aattcagcgc 27841 cttctctcgg tggatctcgc agatccggaa acgagactcg cgctccacct tgcttgccgg 27901 accatcgcgc cctgacggag atcttcgcgg cttcgtcttg acaagcacgg gaggttcctg 27961 ccatcctcgt tgccaggtca cgagtaccag tgttcagccc cggcttgctg gtcggcaacc 28021 ctcctccgcg gtggggtgct ccgggtgacg acccggctgc gttcgaaaac gaatgcggca 28081 agcgcggact cttccggggc catctcccga cgaacgagtc cttgaacgtg aggattgtct 28141 tcgatgactg ctgtattgag tgccgacacc tgctgcacca ccgcgattgc caaggtttcg 28201 ggttccgacc tgcaggttcc attggttcag ggtggcgaat gctcctacgc caacttcgac 28261 tacgccgcga gtgcgccggc attggcccag gtcaccgacc gtatcgccga gttgctgccg 28321 acatacgcca gcgtccaccg cggtgccggc tatgcgtccc ggatctccac gctcacctac 28381 gagaacgctc gtgaatccgt tgctcgtttc gtgaactgtg ccgacgatca ggttgtcgtc 28441 ttcacccgga acaccaccga ttcgctgaac ctgcttgcgc agtgcgtccc cggcagcacc 28501 gtcgtcctcg acgtcgagca tcacgcaaac ctgttgccgt ggaacgacgc tcgtatcgtc 28561 accgccgcag acaccatcga agaaacgatc gagcgtctga tcggtgaact gtgcaccaag 28621 cctgccgcgc tgctcgcaat caccggggcc tccaacgtga ccggtgagat cctgccgatt 28681 gcacgtttgg ctgacatcgc tcaccgttgc ggcgcacgta tcctcgtcga cgctgctcag 28741 ttggctcccc accgtcgcat cgacctgcag gaatgcggcg tcgactacgt agcgttctcg 28801 ggccacaagc tgtacgcgcc cttcggcgcc ggcgttctcg tcggccgccg tgactggctc 28861 gacgaagctc agccgtacct cgccggcggc ggcgccgtgc gtgaggtgac cgtcgaatcc 28921 accgagtggg cttgcgcgcc cgcacgccac gaggcgggtt cccccaacgt gctcggtgcg 28981 gcagccatcg cgaccgcctg cgaaaccctg cacgccctgg acttcgacgt gatcgccgag 29041 catgagaagg cgctcaccgc ccagctcact gacggcttgt ccgccatcga gggcgtctca 29101 ctcgtgcgac tgtggaacga cgctcccgac gccgtcggaa tcgtcacctt caccgtcgac 29161 ggattcgaag cgggcgagat cgccgcattc ctctccgccg agcacggcat cggagttcgc 29221 gacggtcgct tctgcgcaca tccggttctc gcgcgcctcg gcctttccgg cggtgcagtt 29281 cgcgccagcc tcggcctcgg tagcagctcg gacgacgtga cgcggttggt cgacgccgtg 29341 aacatcctgg tttcgaatca gcgtgattgg aagtacgcga agacggcagg tgcgtggaac 29401 cctgtgcccg agacccgccc cttcctcgga gccgcagacg acaatgccgg cgcagccgag 29461 tgcgtctgag ctgagctcgg tccccgaaaa ctcgaacgga caactagcat ggcagccatg 29521 gcaccagcgg attttcccgc caccccttcg agagtgagca tcactctcgg tcagtggtgc 29581 cgtcgccatg tcgatctgtg ccgcacctct tcaggaatgt gttcgagctg acgattcgtc 29641 tcgctcatcc catacttttc tgattttcgg aggtctcaca tgtcttcact cgcttcgcat 29701 tctctgcacg tagcggtcga gttgaccgga tccggtcacc atccggccgc tgagggcgca 29761 cccggcaacc tgcccatcat cggcggcgac tactgggtgg acctcaccga gggtgaaaag 29821 gctctcgatt tggcttcatt ccctaccaat gtggttcgga ttcgcgctgc ggatctgcgt 29881 gaggcacagc tcgaacgcgc acggatacgc gctgccgtcg ccgaagaagg acgcgatccc 29941 gacagcgtcg cagtgctggt cgatctcgag attctgatcg cgccggaggc tcgctccgct 30001 cgtaaggagc ttgcgcagtt ggacagcgcg ttgacctcgc cgcgggttcc cgtttcgctt 30061 cattacgtcg gaacgccttc cggtctcggc agtttgatcg ccgatatccg agctgcggag 30121 gtcgccgacg gcgttacgtt gctgcctctc gcattgcctc gcgcgctcga gcatctggtg 30181 gacagcacca ttccgtggct tcaggatcgc ggacttgtca caccgtccac cgcagtcgac 30241 gaggttctcg ggcgtttcgg actgccgccc cgtcagcgca cgcttgcgtc ctgatcgtca 30301 ccgattgcat ctgcgtacag gtggaacagc gacggtaatt cgtcggcacc gtccacctgt 30361 gccagaagcg tccagcactg cgcagtgatc gaccgagccc tcgtgccgat ccagttggtg 30421 ggcagtagtt ccggcggcaa cagcggatcc ggttccatgg ctcgcgtgaa ttccgccgcg 30481 agttcgatgg tcatcgtgac agcatcggta cccggactgt tctgcagttt gtgcaggcgt 30541 gcggtcgcta cgtcgagtag ccgttcgtat ccgtcagcga tctggtccag tggccacaac 30601 tgcgcggcaa tcttcacggg gtcttcgaga gtgcccactt tcagatctcg agtggtgaga 30661 gaagacaggt gctgttcgac gtcgagttcg gcggccgcat cgcgaatata cggttcccag 30721 gcgtgcggcg agacgtacag accgccctgg acgagcgcgc cgccgaggta aacgaccctg 30781 gtgcgcagcg catctcgccc tttccgtgac gactccggaa ttgcgaatcc ggccaggtgc 30841 cagtacccgt cccacggcgt cacagtgtcg cggtcttgtc gataggccag ccgaacgaat 30901 tcgacgtcgg gttccatctc gcgcagggct ttcggcgttg ctcgtagcgt ggcctgtcgc 30961 ccgcgacctt cctgagtgaa cttcccctcg gtgaccaacc gcttgatgca cagccgaacc 31021 tgttgatcag ttttgccgag ggcgtcggcg gtggcataga gggtgtgccc gtcgacagtt 31081 ccgtccgtgc gcagtagtcc ctcgatcaag atcctcgtgg gtacatcgac gtccctgtcg 31141 gtcatcgcca tgtcctttcc tcgcttctcg acatcttcgc ccacaactgt actatcgaat 31201 gcaatacgat cgtttcaaat tcgtacgtta gggcgggaag atggcagcgg aatcgatgag 31261 cgagggcaag agtaagcctc gtttacgcag gtggatggtt acttccctgg cggtggtcgt 31321 tgttctgatc gcgactctgg tgggctggac gctgtaccag aacacctatg acatccgtga 31381 ggaaaaagtg acgatcaccg ggggatcggt gccgctccag ggagtccttg cactgcccga 31441 acacggtgac ggtcccttcg ggctcgtggt tttcgtccac ggagacggcc cggtcgatgc 31501 aacacatgag acgttctatc gaccggtgtg ggaggcgttc gcaaaggcgg ggtacgcgtc 31561 actctcctgg gacaagccgg gggtgaatgg ggcaccgggc aattggctcg accagagcat 31621 ggacgatcgc gcggcagaaa cggaagcggc aatcgagtgg gcgcggggac gttcggatat 31681 cgatccgtct cggatcggtc tgtggggtgc aagccaggca gggtgggtga tgcccaaggt 31741 ggtgaacctc gacccggacg tagcgttcgt cattgccgtg ggtcccgcga tcaactggct 31801 cca //