LOCUS       NZ_JAJQMN010000005     10402 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Promicromonospora iranensis strain UTMC 3169 Scaffold5, whole genome
            shotgun sequence.
ACCESSION   NZ_JAJQMN010000005
VERSION     NZ_JAJQMN010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Promicromonospora iranensis
  ORGANISM  Promicromonospora iranensis
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
            Promicromonosporaceae; Promicromonospora.
REFERENCE   1  (bases 1 to 479296)
  AUTHORS   Kafshnouchi,M., Poorinmohammad,N., Reyhani,B. and Hamedi,J.
  TITLE     Genome sequencing of Promicromonospora iranensis UTCM 3169 isolated
            from Hampoeil cave
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 479296)
  AUTHORS   Kafshnouchi,M., Poorinmohammad,N., Reyhani,B. and Hamedi,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-DEC-2021) Dept. of Microbial Biotechnology, School of
            Biology, College of Science, University of Tehran, Enghelab Ave.,
            Tehran 141556455, Iran
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 27-SEP-2018
            Assembly Method                   :: SOAPdenovo v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 8x
            Sequencing Technology :: Illumina platform with MPS (massively
            parallel sequencing)
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028994775.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 08:26:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,215
            Genes (coding)                    :: 5,183
            CDSs (with protein)               :: 5,183
            Genes (RNA)                       :: 60
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3, 1 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 32
            CDSs (without protein)            :: 32
            Pseudo Genes (ambiguous residues) :: 0 of 32
            Pseudo Genes (frameshifted)       :: 1 of 32
            Pseudo Genes (incomplete)         :: 30 of 32
            Pseudo Genes (internal stop)      :: 1 of 32
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:56:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 345351
            Orig. end                         :: 355753
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAJQMN010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10402
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10402
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10402
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5402](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5402
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(564..1244)
                     /locus_tag="LUU90_RS11480"
     CDS             complement(564..1244)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020015282.1"
                     /locus_tag="LUU90_RS11480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YigZ family protein"
                     /protein_id="WP_275003557.1"
                     /transl_table=11
                     /translation="MDLPSTIARPVDHEVVIKKSRFLAHLSPAADVAEADAVVARRRKE
                     LWDARHHCVAMVLGTHADGASQTARSSDDGEPSGTAGVPMLEVLRHRDVTDLVAVVTRY
                     FGGVKLGAGGLVRAYSGAVAAALDVASAAGAMLRRELLYEVEVPVPHGDAGRIDNVLRD
                     WASSHGSVMEPPAYDAVAHLRLLVPKQQLDALFADLAAASAGALSPVVGDARVVDVPVP
                     ATRR"
     gene            1399..2004
                     /locus_tag="LUU90_RS11485"
     CDS             1399..2004
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013838680.1"
                     /locus_tag="LUU90_RS11485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_275003558.1"
                     /transl_table=11
                     /translation="MTSTDATSPEARSGELARYPRPPVSLEEAEWVWRELSTEAMRPGA
                     KPEAVRLAVITGLVRATGARYGDLLRVRVEDIDLGPARARATEGSVLVRHGKHRTPRRH
                     LLPADLVVLLRHWMVVREELAAELEGSVPRALLLTVHHTHDNGTTVASGLPITRQGLVL
                     SWRRFVHRTNARYGALRPPLPTRFEQVRRAWVEASMED"
     gene            complement(2090..2722)
                     /locus_tag="LUU90_RS11490"
     CDS             complement(2090..2722)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020015284.1"
                     /locus_tag="LUU90_RS11490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_275003559.1"
                     /transl_table=11
                     /translation="MTEPFIRPYRADDRADVADICVRTAAAGGDARGIYSSDLLMPDVY
                     ALPYVEHSPDLAWVVEHEGRAAGYIIGVADTQAFVEWWAREWTPGFAARHPAPGPATGR
                     NPAYTEAQLLHDGTDPERMVRGLRHGELTTHPAHLHIDLLPVLQRRGLGSRLIDTLRGA
                     LAERGVPGVHLGYAAENTAARLFYDRYGFTELPSSTPQSPLLGIPTT"
     misc_feature    complement(2752..2767)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    2898..2910
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.8"
                     /tool="antismash"
     gene            2943..3461
                     /gene="ectA"
                     /locus_tag="LUU90_RS11495"
     CDS             2943..3461
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020015285.1"
                     /locus_tag="LUU90_RS11495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_275003560.1"
                     /transl_table=11
                     /translation="MQNLEEELKHIHPTETTVALREPTVADGAAMWRLARDSKTLDLNS
                     SYAYLLWARDFARTSVIVSVDGEPGGFVTGYIRPDEPTTLMVWQVAVDHAYRGQRLASR
                     MLAHLAERHPECTHVETTITSDNTASIALFMSFASAQGAPVDVRTVFPAEAFPDGHDAE
                     LVFRIGPLS"
     gene            3596..4879
                     /gene="ectB"
                     /locus_tag="LUU90_RS11500"
     CDS             3596..4879
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (25-359). E-value: 1.5e-75.
                     Score: 246.2. Matches aSDomain:
                     nrpspksdomains_LUU90_RS11500_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020015286.1"
                     /locus_tag="LUU90_RS11500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_275003561.1"
                     /sec_met_domain="Aminotran_3 (E-value: 9.1e-78, bitscore:
                     256.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSNSIFDELESQVRSYCRNWPTTFTTAAGSTLQAEDGRSYLDFF
                     AGAGALNYGHNHPVLLEALIDYLRSGGIVHSLDMHTAPKREFLTTFRDRILAPRGLDYK
                     VMFPGPTGTNSVESALKLARKVTGRQHILSFTNAFHGMTLGALSVTGNSMKRNGAGLPL
                     TNSSKIPYDDYFSGATEDFLWLERVLSDSGSGVDKPAAIIVESVQGEGGLSAARPEWLR
                     ALSELCRAHEILLILDDVQAGCGRTGDFFSFEEAGITPDIVCLSKSISGFGLSMALTLI
                     RPDLDQWEPGEHNGTFRGQNTSFVTGTAALNEFWSDDTFSQTVKERGDELHDGLARIAG
                     GYEGAVVKGRGFLAGIKFPDPSAASRIAAASYERGLLVETSGPEDEVLKTMPALTITSD
                     ELRSGVDIIAAAADEVLGAPVANLASAK"
     aSDomain        3671..4672
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LUU90_RS11500_Aminotran_3.1"
                     /evalue="1.50E-75"
                     /label="LUU90_RS11500_Aminotran_3.1"
                     /locus_tag="LUU90_RS11500"
                     /protein_end="359"
                     /protein_start="25"
                     /score="246.2"
                     /tool="antismash"
                     /translation="TTAAGSTLQAEDGRSYLDFFAGAGALNYGHNHPVLLEALIDYLRS
                     GGIVHSLDMHTAPKREFLTTFRDRILAPRGLDYKVMFPGPTGTNSVESALKLARKVTGR
                     QHILSFTNAFHGMTLGALSVTGNSMKRNGAGLPLTNSSKIPYDDYFSGATEDFLWLERV
                     LSDSGSGVDKPAAIIVESVQGEGGLSAARPEWLRALSELCRAHEILLILDDVQAGCGRT
                     GDFFSFEEAGITPDIVCLSKSISGFGLSMALTLIRPDLDQWEPGEHNGTFRGQNTSFVT
                     GTAALNEFWSDDTFSQTVKERGDELHDGLARIAGGYEGAVVKGRGFLAGIKFP"
     misc_feature    complement(4938..4947)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            5001..5402
                     /locus_tag="LUU90_RS11505"
     CDS             5001..5402
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020015287.1"
                     /locus_tag="LUU90_RS11505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_275003562.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.3e-51, bitscore:
                     168.6, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVTRLADLDGTDRDVRSENWRSRRLVLAKEGVGFSFHETTMYAG
                     TETEMWYANHFEAVYCVGGTGLLENRETGEIHEISDGTMYLLDGNEKHTMRPTTDLRLI
                     CTFNPPVTGREVHDENGVYPLIKEEEAAV"
     gene            5399..6322
                     /gene="thpD"
                     /locus_tag="LUU90_RS11510"
     CDS             5399..6322
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010524906.1"
                     /locus_tag="LUU90_RS11510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_275003563.1"
                     /sec_met_domain="PhyH (E-value: 1.2e-37, bitscore: 125.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDAISTTQETVTQPDDLYPTRVEGPASEIPRQDKVVWGSAADG
                     PMEQELLDGFDRDGYLVLEDLVTPSEVEEFRAELQRLSTDPVVRADERTIIEGTSQQVR
                     TIFEVHRSSDVFARIANDPRVVGRARQILGSDVYIHQSRVNLKPGFGGGDFAWHSDFET
                     WHAEDGLPRMRTVSISISLTDNYSFNGPLMIMPGTHKTYVSCTGRTPNDNYKSSLVMQN
                     AGTPDEDILTRMADEHGIDVLAGKAGSAIMFDCNCMHGSNGNISPYPRSNIFLVYNSVE
                     NTAVEPFAADAPRPTFLGTRDFTPVG"
     gene            complement(6433..6945)
                     /locus_tag="LUU90_RS11515"
     CDS             complement(6433..6945)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013117135.1"
                     /locus_tag="LUU90_RS11515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="WP_275003564.1"
                     /transl_table=11
                     /translation="MSPKLPRYTVPSLTPEEGAKVAEILQERLHALNDLHLTLKHVHWN
                     VVGPHFIGVHEMLDPQVDAVRAMVDQIAERIATLGSVPVGTPGALVAARSWEDYKLGRA
                     PAIEHLAALDDVYDSVITFHRKAADDTAGVDDVTNDLLIGHLHELEQFHWFVRAHLESA
                     SGAIPET"
     gene            complement(7012..7620)
                     /locus_tag="LUU90_RS11520"
     CDS             complement(7012..7620)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LUU90_RS11520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275003565.1"
                     /transl_table=11
                     /translation="MTPSPLTTLARRITLHLADPARRPLPTITVETGPTLRGWTFRAAL
                     LALVPLLLFTAAARTPEIPHGVTLTIAALATGLLVVHPTPTTAGGTIAVAAVLFWGFTT
                     EPFDPWALVLALLAYLIARTTWWAAHVPPRGHAEIAALLSDWRRDLTVLAATALLGALA
                     MLASGTTIQGAILLAALAVVGLVLVALATDGSSRDDGRS"
     gene            complement(7617..9020)
                     /locus_tag="LUU90_RS11525"
     CDS             complement(7617..9020)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020015291.1"
                     /locus_tag="LUU90_RS11525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF58 domain-containing protein"
                     /protein_id="WP_275003566.1"
                     /transl_table=11
                     /translation="MTVGGIIVARGRTSQGAPAGSHHGWRPTSAYTAAIATGILLLTTS
                     LLAGRADIALIGIPSLLAATWAHTTRPTTPLRATLHEPPGTTTPGELTATLHLTTAPGT
                     TPDPRAHHPADIAHLRITATGHRDTHLALAARTTPRDAGRQIPLRLSTVRTGPQETFTV
                     DLRGSRHRTWEEEPTQVRGATRLVLPGAAPLGRLPLPRRLRGLTGPHSSRRLGDGAELR
                     DIHAFTPGDRLRRIDWRTTARRSPELDTLYVRRTYATAEATAVLVVDSRDEVGPDIRTW
                     RGYGTIRVDEPTSLDLARHAAASVATALVDAGDRVGLEDLARRRRPLPPAAGRRHLRRL
                     IHGLALAHPKDAASLHRVRPPQLPADAIVYLFTTLLDDEPLHLVRTWRTTGHPVVVIDT
                     LPDIHHVLERHLAIAWRIARLERENRIATLDGEHVPVISWAGSRRDQATVRFEALARAD
                     QRHVPGRVP"
     gene            complement(9017..10033)
                     /locus_tag="LUU90_RS11530"
     CDS             complement(9017..10033)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020077532.1"
                     /locus_tag="LUU90_RS11530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MoxR family ATPase"
                     /protein_id="WP_275003567.1"
                     /transl_table=11
                     /translation="MPDRTTPQTSPATTPVTSPLPVADVAALGERVLAEVGTAVVGMRD
                     ALETALATILAGGHVLFEDVPGLGKTLAARSLAAALGLDFARLQCTPDLLPADITGSSV
                     FDPATRTFEFRPGPVFTGLFLADEINRTAPKTQSALLEAMAERQVSIEGTSRPLPNPFH
                     VLATSNPVEYEGTYPLPEAQLDRFMVRLAVGYPDRTQETEVLTRRLARKQEATTVNQVV
                     DPATVRAMQAGTEQVTVDPDVVRYCVDLTAATRGHQALEVGASPRGSQNLVLLARAIAV
                     LDGRDYVLPEDVKRVAVPVLAHRITLTPTAWASATRPETIVADLLHTVPTPATVPTR"
ORIGIN
        1 tggcggggtc cagcgtgtcc atcgcttcct gcacgacgtc ggtgtcgagc agcccctggg
       61 actgccagga cgtgatctgc gaggcgccgg cgaggacgac atcgggcacc tcgcccgacg
      121 cggcgcccgt gaccagcgcc tggtcctggt cggccgccgc gagcgggacg acgtcgaccg
      181 cgatgccggt ctcctcggtg aaccgttcgg cgaccgcttc ctgcgcggcc acacgctccg
      241 gtgtggactg tggcgtccag aaggtgatgg attcggcctg cccctcctgc tcggcactcg
      301 ggccgcaggc ggcgaggagg gtggcgacgg cggtcagtgc gacgacgacg gcggacgagc
      361 ggatgcgacg gtgcattggt ccctcttcgg tgctggtgcc ggtgcgggtg tcccagagac
      421 ttcacccgca cgccgggtca gtcaaggctg acgcgcggga ggacccgtgc tcgccgccga
      481 ccgggtccgc tgcggggctc caaacgagtg accccgacac actgcacgcg acacacgaca
      541 cggggcgcag tgtgtcgggg tcgtcagcga cgggtggccg gcaccggcac gtcgaccacc
      601 cgggcgtcgc cgacgacggg ggagagggca ccggcagagg cggcggcgag gtcggcgaac
      661 agggcgtcca gctgctgttt gggcaccagc agccgcaggt gcgcgacggc gtcgtaggcg
      721 ggcggttcca tcacggagcc gtgggacgac gcccagtcgc gcagcacgtt gtcgatccgc
      781 ccggcatccc cgtggggaac gggcacctcg acctcgtaca gcagctcacg gcggagcatc
      841 gccccggcgg cggacgcgac gtcgagcgcg gcggccaccg ctcccgagta ggcccggacg
      901 agcccgccgg ccccgagctt caccccgccg aagtagcggg tgacgacggc gaccaggtcc
      961 gtgacgtcgc ggtggcgcag cacctccagc atggggacgc cggccgtgcc gctcggctcg
     1021 ccgtcgtcgg aggagcgggc tgtctggctc gcgccgtcgg cgtgcgtccc gagcaccatg
     1081 gccacgcagt ggtggcgggc gtcccacagc tccttgcgcc ggcgcgcgac gacggcgtcg
     1141 gcctccgcga cgtcggcggc aggggagagg tgggccagga accgggattt cttgatgacc
     1201 acctcgtggt cgacgggccg tgcgatggtg ctggggaggt ccaccggacg agcgtacgtg
     1261 gcggtgccag gggtggagcc ggcccggctc ctgccgagac ccgcaccgtg ccgagcagcg
     1321 ccgagcggat ctcaccggat cgccgacacg cgagaaacta cccttgatta atagtgtgcc
     1381 aagcgtagat tgacagccat gaccagtacc gacgccacgt cgccagaagc acggagcggg
     1441 gagctcgccc gctacccgcg gccgcccgtg agcctcgaag aggccgaatg ggtctggcgc
     1501 gagctctcca ccgaggcgat gcgaccgggc gcgaagccgg aggcggtgcg gctcgcggtg
     1561 atcaccggcc tggtgcgtgc gacgggcgca cggtacggcg acctgctgcg ggtgcgtgtc
     1621 gaggacatcg acctcggtcc cgcacgggcg cgggcgacgg agggcagcgt gctggtgcgg
     1681 cacggcaagc accgcacgcc gcggcgccac ctgttgccgg ccgatctggt ggtgctcctg
     1741 aggcactgga tggtcgtgcg cgaggagctg gcggccgagc tggagggctc ggtaccgagg
     1801 gcgctgctgc tcacggtgca ccacacgcac gacaacggca ccacggtcgc gtccggcctg
     1861 ccgatcacgc ggcagggact ggtgctgtcg tggcggcggt tcgtgcatcg gaccaacgcg
     1921 cgctacggcg cgctgcgccc accgctgccg acccggttcg agcaggtgcg gcgggcgtgg
     1981 gtggaggcgt cgatggagga ctgacccagc ctcacccacc cgcctcgttg agtgctggat
     2041 atttgcgctt ccgggagcat cgagagcgca gatatccagc actcaacggt caggttgtgg
     2101 ggatgcccag gagcggggac tgcggggtcg acgacggcag ctctgtgaac ccgtaccggt
     2161 cgtagaacag ccgggcggcg gtgttctcgg ccgcgtagcc caggtgcacg cccggcacgc
     2221 cacgctcggc gagggcgcca cggagcgtgt cgatgagacg cgagccgagg cctcgccgct
     2281 ggagcacggg cagcaggtcg atgtgcaggt gggccgggtg ggtcgtgagc tcgccgtgcc
     2341 gcagcccccg gaccatgcgc tccgggtcgg tgccgtcgtg cagcagctgg gcctcggtgt
     2401 aggcggggtt gcgcccggtc gccgggccgg gcgctgggtg ccgggcggcg aagcccggcg
     2461 tccactcccg tgcccaccac tcgacgaaag cctgggtgtc ggcgacgccg atgatgtacc
     2521 cggccgcacg gccctcgtgc tcgaccaccc acgcgaggtc gggggagtgc tccacgtagg
     2581 gcagcgcgta gacgtcgggc atgagcaggt cggacgaata gatgcctcgt gcgtcaccgc
     2641 cggccgcggc ggtgcggacg cagatgtccg cgacgtcggc acggtcgtcg gcgcggtagg
     2701 ggcggatgaa tggctcggtc acaccggcac actagcttgc cgtcccagac tgtgaccgtg
     2761 ctgtgacatg acgtcggcgc gctcgttgcc ggaccccgta cgagccgcat gttggcgctg
     2821 gtcagtggca gatccgaccc tccgccgtta ctgcgtattt gccccgcgag gatgccagta
     2881 acgggatcgt cacaggatcg caatgtgcaa tcgtcgcgca agttcgttac ggtcgttttg
     2941 tcatgcagaa cctcgaagag gaactcaagc acatccatcc gaccgagacc acggtggcgt
     3001 tgagggagcc caccgtcgca gacggagcag cgatgtggcg cctcgcgcgc gactccaaga
     3061 cgctggacct gaactcgtcc tacgcgtatc tcctctgggc gcgagacttc gcccggacct
     3121 cggtgatcgt gagcgtcgac ggcgaacccg gtgggttcgt cacgggctac atccggcccg
     3181 acgagccgac caccctgatg gtctggcagg tagccgtgga ccacgcctac cgtggacagc
     3241 ggctggcctc ccggatgctc gcgcacctcg ccgagcggca ccccgagtgc acccacgtgg
     3301 agacgaccat cacctcggac aacacggcgt cgatcgccct gttcatgtcc ttcgcgtcgg
     3361 cacagggtgc gcccgtcgac gtgcggaccg tcttccccgc ggaagcgttc ccggacggcc
     3421 acgacgcgga gctggtgttc cgcatcggcc cgctctcctg acctcgtcca ggtcgatccc
     3481 cgaagaatca aaccccagaa gaccgcagaa gaaccgatct accacagccg agtccggtca
     3541 acgggaccgg accgtggaag gagccatgcg cccgaacacc gctatgccta caggcatgcc
     3601 ctcgaacagc atcttcgacg agctcgagtc ccaggtccgc agctactgcc ggaactggcc
     3661 cacgacgttc acgaccgccg ccggcagcac gctgcaggcc gaggacggcc gaagctacct
     3721 cgacttcttc gccggggctg gtgcgctcaa ctacgggcac aaccacccgg tactgctcga
     3781 ggcgctgatc gactacctgc gaagcggcgg gatcgtgcac tcgctcgaca tgcacaccgc
     3841 acccaaacgc gagttcctca cgacgttccg ggaccggatc ctggcgccgc gcggcctgga
     3901 ctacaaggtc atgttccctg gcccgaccgg gacgaactcc gtcgagagcg cgctcaagct
     3961 ggcccgcaag gtcaccggtc gccagcacat cctctcgttc accaacgcgt tccacggcat
     4021 gacgctgggc gccctgtcgg tgacggggaa ctccatgaag cgcaacggcg ccggcctgcc
     4081 gctcacgaac agctcgaaga tcccgtacga cgactacttc tccggcgcca cggaggactt
     4141 cctgtggctc gaacgcgtgc tcagcgacag cgggtccggc gtcgacaagc ccgccgcgat
     4201 catcgtggag tccgtccagg gcgagggcgg tctcagcgcc gcgcggcccg agtggctgcg
     4261 cgccctgtcc gagctctgcc gcgcgcacga gatcctgctg atcctcgacg acgtgcaggc
     4321 cggctgcggc cgcaccggtg acttcttcag cttcgaggag gccgggatca ccccggacat
     4381 cgtctgcctc tcgaagtcga tctccggctt cgggctgtcg atggcgctca cgctgatccg
     4441 gcccgacctg gaccagtggg agccgggcga gcacaacggc acgttccgcg gtcagaacac
     4501 gtcgttcgtc acgggtaccg cggcgctgaa cgagttctgg tccgacgaca cgttctcgca
     4561 gacggtcaag gagcgcggcg acgagctgca cgacggcctg gcgcggatcg ccggcgggta
     4621 cgagggcgcc gtcgtcaagg ggcgcggctt cctcgcgggc atcaagttcc cggacccctc
     4681 cgccgcgtcc aggatcgccg ccgcgtcgta cgagcgcggc ctgctggtcg agacgtccgg
     4741 ccccgaggac gaggtgctca agaccatgcc ggccctgacg atcacgtccg acgagctgcg
     4801 gtccggcgtg gacatcatcg cggccgcggc cgacgaggtg ctcggcgcac ccgtcgcgaa
     4861 cctcgcgtcc gcgaagtaga gccgccgcga cggccccgcg gtgcagatcc ctgccacccg
     4921 gggccgtcgc gacgccgggc cgccttcgcg cgggcccgga accccagggc gggaacagcc
     4981 cccgaggaaa ggaacaccag gtgatagtca ctcgactggc cgatctcgac ggtaccgacc
     5041 gcgatgtcag gtcggagaac tggcgcagcc gcaggctcgt gctcgccaag gagggcgtcg
     5101 gtttctcgtt ccacgagacc accatgtacg ccggcaccga gacggagatg tggtacgcca
     5161 accacttcga ggccgtgtac tgcgtcggcg gtaccgggct gctcgagaac cgcgagaccg
     5221 gcgagatcca cgagatctcg gacggcacga tgtacctgct cgacggcaac gagaagcaca
     5281 cgatgcgtcc cacgacggac ctgcggctga tctgcacctt caacccgccg gtcacggggc
     5341 gggaggtgca tgacgagaac ggcgtgtacc cgttgatcaa ggaagaggag gccgctgtat
     5401 gacgacggac gcgatcagca cgacccagga gaccgtcacc cagccggacg acctgtaccc
     5461 cacgcgggtg gagggaccgg catccgagat cccgcgccag gacaaggtgg tctggggcag
     5521 cgcggccgac ggcccgatgg agcaggagct cctggacggc ttcgaccggg acgggtacct
     5581 cgtgctcgag gacctggtga cgccgtcgga ggtcgaggag ttccgggcgg agctccagcg
     5641 gctgtccacc gacccggtgg tccgcgcgga cgagcgcacg atcatcgagg gcacgtcgca
     5701 gcaggtgcgc acgatcttcg aggtgcacag gtcgagcgac gtcttcgcgc gcatcgcgaa
     5761 cgacccgcgg gtggtgggca gggcgcgtca gatcctcggc tcggacgtgt acatccacca
     5821 gagccgcgtg aacctgaagc ccggtttcgg cgggggcgac ttcgcctggc actcggactt
     5881 cgagacctgg cacgccgagg acggcctgcc gcggatgcgg acggtcagca tctcgatctc
     5941 gctgaccgac aactactcgt tcaacggtcc gctgatgatc atgccgggga cgcacaagac
     6001 gtacgtgtcc tgcaccggcc ggacgccgaa cgacaactac aagtcgtccc tggtgatgca
     6061 gaacgccggc acccctgacg aggacatcct cacgcggatg gccgacgagc acggcatcga
     6121 cgtgctcgcg ggcaaggccg gcagcgcgat catgttcgac tgcaactgca tgcacggctc
     6181 gaacggcaac atctcgccgt acccgaggtc gaacatcttc ctcgtctaca acagcgtgga
     6241 gaacacggcg gtcgagccgt tcgcggcgga tgcgccccgc ccgaccttcc tcgggacccg
     6301 ggacttcact ccggtcggct gactccggac gcacagggct cgcccgcacg gaagccccag
     6361 gtcaccggtt gacctggggc ttccgtcatg agccgtgctg ggtgtgccgt gtcgtcgtgg
     6421 cgccggccgg gatcacgtct cggggatcgc cccggacgcc gactccaggt gcgcacggac
     6481 gaaccagtgg aactgctcga gctcgtgcag gtggccgatg agcaggtcgt tcgtcacgtc
     6541 gtcgacgccg gcggtgtcgt cggcggcctt gcggtggaac gtgatcaccg agtcgtagac
     6601 gtcgtcgagc gccgccaggt gctcgatcgc gggggcccgg cccagcttgt agtcctccca
     6661 gctgcgggcg gcgacgagag caccgggcgt acccaccggc acgctgccga gggtggcgat
     6721 gcgctcggcg atctggtcga ccatcgcgcg cacggcgtcg acctgcgggt cgagcatctc
     6781 gtggacgccg atgaagtgcg gtcccaccac gttccagtgc acgtgcttga gggtgaggtg
     6841 caggtcgttc agcgcgtgca gccgctcctg gaggatctcc gcgaccttgg ccccctcctc
     6901 gggtgtcagg gacgggacgg tgtagcgggg cagcttcggg gacatgtcgg tcctctcttc
     6961 cggcgatgct tcgggccgct cgtgcggccg ctcctcggac gacctgggtc gtcagctccg
     7021 tccatcgtca cgcgaggagc cgtcggtcgc cagtgcgacg agcacgaggc cgaccacggc
     7081 gagcgccgcg agcaggatgg cgccctggat ggtggttccg gaggcgagca tcgcgagggc
     7141 gccgaggagg gcggtggcgg cgaggacggt gaggtcgcgt cgccagtcgg agaggagtgc
     7201 tgcgatctcg gcgtgtcctc ggggtggtac gtgggcggcc caccaggtgg tgcgggcgat
     7261 gaggtaggcg aggagggcga ggaccagggc ccaggggtcg aagggttcgg tggtgaagcc
     7321 ccagaaaagc actgcggcga cggcgatggt gccgcctgct gtggtggggg tggggtggac
     7381 gaccaggagg ccggtggcga gggcggcgat ggtgagggtg acgccgtggg ggatctcggg
     7441 tgtgcgtgcc gcggcggtga agagcaggag cgggacgagg gcgaggaggg cggcgcggaa
     7501 ggtccagccg cggagggtgg gtccggtctc gacggtgatc gtgggcaggg gtctgcgtgc
     7561 ggggtcggcg aggtggagcg tgatgcggcg ggcgagggtg gtgagggggc tgggggtcat
     7621 gggacgcgtc cgggtacgtg gcgttggtct gcgcgggcga gggcttcgaa gcggacggtg
     7681 gcctggtcgc gtcgggagcc ggcccagctg atgacgggga cgtgttcgcc gtcgagggtg
     7741 gcgatgcggt tctcgcgttc gaggcgggcg atgcgccagg cgatggcgag gtgtcgttcg
     7801 aggacgtggt ggatgtcggg gagggtgtcg atgacgacga cggggtggcc ggtggtgcgc
     7861 caggtgcgga cgaggtgcag tggttcgtcg tcgagcaggg tggtgaagag gtagacgatg
     7921 gcgtcggccg ggagctgtgg tgggcgtacg cggtgcaggg aggcggcgtc tttcgggtgg
     7981 gccagtgcga ggccgtggat gaggcggcgg aggtggcgtc gtccggctgc gggtggcagg
     8041 gggcggcgtc ggcgggcgag gtcttcgagg ccgacgcggt cgcctgcgtc gacgagggcg
     8101 gtggcgacgg aggctgcggc gtggcgggcg aggtcgagcg atgtgggctc gtcgacgcgg
     8161 atggtgccgt agccgcgcca ggtgcggatg tcgggtccta cctcgtcgcg ggagtcgacg
     8221 acgagcacgg cggtggcttc ggcggtggcg taggtgcggc ggacgtagag ggtgtcgagc
     8281 tcgggggagc ggcgggcggt ggtgcgccag tcgatccggc ggaggcggtc gccgggggtg
     8341 aaggcgtgga tgtcgcggag ctctgcgccg tcgccgagtc ggcgggagga gtgtggtccg
     8401 gtgaggccgc ggagtcgtcg gggcaggggg agtctgccga gcggggcggc gccggggagg
     8461 acgaggcggg tcgcgccgcg gacctgggtg ggctcttcct cccaggtgcg gtgccgggat
     8521 ccgcgcaggt cgacggtgaa cgtctcctgg gggccggtgc ggacggtcga gaggcggagc
     8581 gggatctggc gtccggcgtc cctgggtgtg gtccgtgcgg cgagtgcgag gtgggtgtcg
     8641 cggtgtccgg tggcggtgat gcggaggtgg gcgatgtcgg cggggtggtg ggcgcggggg
     8701 tccggggtgg tgccgggtgc ggtggtgagg tggagcgtgg cggtgagctc gccgggggtg
     8761 gtggtgccgg gtggttcgtg gagggtggcg cgcaggggtg tggtggggcg ggtggtgtgc
     8821 gcccaggtgg cggcgaggag gctgggtatg ccgatgaggg cgatgtcggc gcggccggcg
     8881 aggaggctgg tggtgagcag gaggatgccg gtggcgatgg cggcggtgta cgcggaggtg
     8941 ggtcgccagc cgtggtggct gcctgctggt gcgccctggg atgttcgtcc gcgggcgacg
     9001 atgatgccgc cgacggtcat cgggtgggga ccgtggcggg ggtggggacg gtgtgcagga
     9061 ggtcggcgac gatggtctcg ggccgggtgg ccgacgccca ggcggtgggg gtgagggtga
     9121 tgcggtgggc gaggacgggg acggcgacgc gcttgacgtc ctcggggagg acgtagtcgc
     9181 gtccgtcgag gacggcgatg gcgcgggcga ggaggacgag gttctgtgag ccgcgggggg
     9241 aggcgccgac ctcgagggcc tggtggccgc gggtggcggc ggtgaggtcg acgcagtagc
     9301 ggacgacgtc ggggtcgacg gtgacctgtt ccgtcccggc ctgcatggcg cggacggtgg
     9361 cggggtcgac gacctggttg acggtggtgg cttcctgctt gcgggccagg cgccgggtga
     9421 ggacctcggt ctcctgggtg cggtcggggt agccgacggc gaggcggacc atgaagcggt
     9481 cgagctgggc ctcgggcagg gggtaggtgc cctcgtactc gacggggttg gaggtggcca
     9541 gcacgtggaa ggggttgggc agggggcggc tggtcccttc gatggagacc tgtcgttcgg
     9601 ccatggcctc gaggagcgcc gactgggtct tcggggcggt gcggttgatc tcgtcggcga
     9661 ggaagaggcc ggtgaagaca ggtccggggc ggaactcgaa ggtacgggtg gcggggtcga
     9721 agacggacga tccggtgatg tccgcgggca gcaggtccgg ggtgcactgg aggcgggcga
     9781 agtcgaggcc gagggcggcg gccagcgagc gcgcggcgag ggtcttgccg aggccgggta
     9841 cgtcctcgaa gaggacgtgt cctccggcga ggatggtggc gagggctgtc tcgagcgcgt
     9901 cgcgcatgcc gacgacggcg gtcccgacct cggcgaggac tcgttcgccg agcgctgcga
     9961 cgtcggcgac gggcaggggg ctggtgaccg gggtcgtcgc cgggctggtc tgcggggtgg
    10021 tgcggtcagg cacggttctc ctcggtggtg ggtgcggcac cgaggcgttc tatcgcgtcg
    10081 agccaggtct ggacggtgcg cgccgtgggg ggttgcctgg acttgagctg gcgcaggacg
    10141 cgagcgccga ggagccgttc ggcgtcgggc tcggcggcgg ggtcggaggg gtcgacgccg
    10201 tgtgcgcgga gccggtcggc ggcgagggcg cggatgcggc ggacgatgcg gtcggtgacg
    10261 tagccgtcgc ggccgaagac ggaccagccg aggtcggaca cgtcgtggcg tccgccggcg
    10321 cgggcctcga cggggggtcg gggccattcg gggtcgtcgg tggtggcgtc ggtggctgac
    10381 cacaggatgc ccagcgcgca gg
//
