LOCUS       NZ_JARBUT010000006     23910 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Nocardiopsis sp. N85 Scaffold6, whole genome shotgun sequence.
ACCESSION   NZ_JARBUT010000006
VERSION     NZ_JARBUT010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardiopsis sp. N85
  ORGANISM  Nocardiopsis sp. N85
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 313853)
  AUTHORS   Liu,S.
  TITLE     Nocardiopsis sp. N85
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 313853)
  AUTHORS   Liu,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2023) Microbial Chemistry, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences, Tiantanxili No.
            1, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 182.0x
            Sequencing Technology :: combinatorial probe-anchor synthesis
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028882275.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 06:01:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,729
            CDSs (total)                      :: 5,663
            Genes (coding)                    :: 5,611
            CDSs (with protein)               :: 5,611
            Genes (RNA)                       :: 66
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 9 of 53
            Pseudo Genes (incomplete)         :: 46 of 53
            Pseudo Genes (internal stop)      :: 0 of 53
            Pseudo Genes (multiple problems)  :: 3 of 53
            CRISPR Arrays                     :: 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:47:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9109
            Orig. end                         :: 33019
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JARBUT010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23910
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23910
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23910
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13910](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13910)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    235..253
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.17"
                     /tool="antismash"
     misc_feature    1715..1733
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.57"
                     /tool="antismash"
     misc_feature    complement(1720..1738)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     misc_feature    2064..2080
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     misc_feature    2085..2099
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.46"
                     /tool="antismash"
     misc_feature    complement(2106..2123)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.42"
                     /tool="antismash"
     misc_feature    complement(2472..2489)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    complement(2619..2632)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.31"
                     /tool="antismash"
     misc_feature    2641..2657
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.86"
                     /tool="antismash"
     gene            2671..3612
                     /locus_tag="PWG71_RS10370"
                     /old_locus_tag="PWG71_10370"
     CDS             2671..3612
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033634.1"
                     /locus_tag="PWG71_RS10370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10370"
                     /product="SLATT domain-containing protein"
                     /protein_id="WP_274809402.1"
                     /transl_table=11
                     /translation="MTDSADDQTTSESPKSANEVQTSGENEKLLLLNHEVREAEFALNF
                     AQRRRKWSNLSLFFGPLLGLALYIMLWVPWISSEIKGVIMLPAAPTAIAFCVYSYRLKR
                     DPGGPLNYQGEKDHGGKDETDRDEPRSRSSRRLSEGEIELVISQIKDARKLLLANAGVS
                     ISVRRITYKEDAYSEIDQFRTESRKFRNVHNLLQGIVIIGSLGATGMAGLVVQIPEIRW
                     AILFVTFLVGVASGFMGYFKYKERSFYLQQTADAVESEWEAVEIGVGRYKHIKEEEDQL
                     AEFVAEVHRLKSEQKKRQQNLEQPPETRSGND"
     gene            complement(3887..5362)
                     /locus_tag="PWG71_RS10375"
                     /old_locus_tag="PWG71_10375"
     CDS             complement(3887..5362)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019611261.1"
                     /locus_tag="PWG71_RS10375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10375"
                     /product="site-specific integrase"
                     /protein_id="WP_274809403.1"
                     /transl_table=11
                     /translation="MTAYEGSVFKRCGCREENSGRALGVKCPRLRREDGAWNPRHGNWW
                     FQLELPRTGEGKRRQARRGGLGTQEEARRQLDHVKALLALAEGEPDLEIHVADLIQAAL
                     KGRRPLPEVEEVRKRIGAGVDARREPPLAGEWLREWLDGKPDLAEGTRASYDGHIRKYL
                     VPHLGKVRVDRLQARQVEAMFAKVEEANVHILECRESEDPQVRRSVRGRRVISLSTKHR
                     IRATLRSALSDAVRSPDLPVSVNIASHVRLPSCPRKRPLVWTADRVRQWEKGGTVPGEV
                     MVWTPEQTRTFLQHARRYTWLFPMFHLIAVKGLRRGEAVGLPWANTRLVDGQIDIRVQV
                     VQLAWETITSTPKSAAGQRTITLDADTIKILRGWKRFQNEQRLQTGKHWNQTGLVFTRQ
                     DGSGWHPGQVSDWFCRIAKAAGLPPITLHGLRHGAASLALAAGTDVKVVSVELGHATTH
                     FTQDTYQSVYPDVAKAAAEATAALLRGEPVSVG"
     gene            complement(5371..5691)
                     /locus_tag="PWG71_RS10380"
                     /old_locus_tag="PWG71_10380"
     CDS             complement(5371..5691)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014910099.1"
                     /locus_tag="PWG71_RS10380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10380"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_274809404.1"
                     /transl_table=11
                     /translation="MFVQFRGGEEVGAVNRDAPVRLAEITSLPVALSPVQAGRLLGLGR
                     TTVYRLLREEAFPVPVQRVGRSWVIPTAGVLAYLGLNLPATSAATTDGCGCGARVNATE
                     ER"
     misc_feature    6978..6992
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 23.72"
                     /tool="antismash"
     misc_feature    complement(7328..7343)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.6"
                     /tool="antismash"
     gene            complement(7346..7846)
                     /locus_tag="PWG71_RS10385"
                     /old_locus_tag="PWG71_10385"
     CDS             complement(7346..7846)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS10385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_10385"
                     /product="hypothetical protein"
                     /protein_id="WP_274809406.1"
                     /transl_table=11
                     /translation="MEHPTTGRHRRPCDSMAGRVWALTAALLATALAALFDPRPPRLPR
                     RVPRALPAAPPSVTASRKGDLLADHLGFPEQHVWESGVSAASARWEQAYRDRSAPFEAE
                     DRVDVDPDLVAGALVRPYLNLGSVPRPRPAEPKDYPATPPVPDEEEFAELADRIRAYLA
                     LRG"
     gene            complement(8040..8633)
                     /locus_tag="PWG71_RS10390"
                     /old_locus_tag="PWG71_10390"
     CDS             complement(8040..8633)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570054.1"
                     /locus_tag="PWG71_RS10390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10390"
                     /product="ATP-binding protein"
                     /protein_id="WP_274809407.1"
                     /transl_table=11
                     /translation="MVPMSAVGPHDPGTTELPPLPQATLPLWDVVPARARHYFHHAPDR
                     GAYTTRRYEFGSSLELLPLVRAFLNTCAAHRDADYRYLFTLLGSELVNNALTHSRSGHP
                     HGRYALTCRRRGNGLHLTCADQGDASGRTTPAGETHHLVPDPQRLAPEAEHGRGLAMLD
                     ALATGWGDNGIADLRQVWFFLAYDLTDNRWTQAS"
     misc_feature    8794..8803
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     gene            8905..9762
                     /locus_tag="PWG71_RS10395"
                     /old_locus_tag="PWG71_10395"
     CDS             8905..9762
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="PWG71_RS10395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10395"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_274809408.1"
                     /transl_table=11
                     /translation="MPDEPSLRQRWLGTHLEALRREAGFSLQEASRAAQRSTASLSRIE
                     NGVVALPARDVRPLLDAYGVEDRDARETLIAVAGEVEAERRGWWVEHSDTLSPSYLDLL
                     RLEATASEVRTYETSVIPGLLQHEDYARRAVALTSSTALSEDALERFIAVRRQRQRILH
                     RAEEPTALHAVIHEAALHQTLDAPEALAQQLELLRELMSHPLITVQVLPLSAPHPALAG
                     AFTLVETHRLTWVHVELQTSDVYLEAPQSVVPYMACFKVLSERALSPTESVKAINARLD
                     ALTP"
     misc_feature    complement(9781..9796)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.34"
                     /tool="antismash"
     misc_feature    9784..9799
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.99"
                     /tool="antismash"
     gene            9794..9988
                     /locus_tag="PWG71_RS10400"
                     /old_locus_tag="PWG71_10400"
     CDS             9794..9988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626261.1"
                     /locus_tag="PWG71_RS10400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10400"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_274809409.1"
                     /transl_table=11
                     /translation="MNSTLRSSWYKSSYSTAQSNCVEVAESVAGNAVRDSQHPELGHLD
                     FPAEEWFGLLAPLKQRVNR"
     gene            complement(10001..11140)
                     /locus_tag="PWG71_RS10405"
                     /old_locus_tag="PWG71_10405"
     CDS             complement(10001..11140)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608872.1"
                     /locus_tag="PWG71_RS10405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10405"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_274809410.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-38, bitscore:
                     126.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPDSILTATDTSPLSLNGGTLGTALLYLATGSPPETVHTLLRT
                     ALADGPIDPASRNTLFHGLPAVAFLLSLTPPEGYRSARTTVREHLIALTRHRLAAATRR
                     IEDGRLTSFAEYDLITGLTGIGVALRSIDPDGDLLDDLLRYLVRLTRPIRHEHHERPGW
                     WVHHGPQAHPDPDFPEGHANLGLAHGISGVLGFLALTHRDGRTVDGHTEALERLCAALD
                     EHEHHDGERTWWPGWVSTGHPAPLTRPGPPSWCYGTPGIARARQLAALALGDTPRRLHA
                     EQAMDTCLSDPRLVNHFTDGGLCHGPAGLLQVLRRMSEDQPAVRPEQRLERHLPAVREH
                     AAAPFPHRESGLLEGKEGTTMALAGRASALAWDRCLLLV"
     gene            complement(11127..13910)
                     /locus_tag="PWG71_RS10410"
                     /old_locus_tag="PWG71_10410"
     CDS             complement(11127..13910)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608871.1"
                     /locus_tag="PWG71_RS10410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10410"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274809412.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-13,
                     bitscore: 44.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.1e-83, bitscore:
                     273.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-19, bitscore:
                     64.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYAPLATITPSLRAATRLRTRLPAYPDPATGSPAELRAWITGLGD
                     DRELMRALRIASPSLDAAVQRMAAPDQLEEARVRRTAFTVVRYLLRAHCRATPFGLFAG
                     VAPLTLGAETSVTWHGPHQEVPRLGTGKARGQFSQASGEVERSVVLAQTVRVHGERLCL
                     DHRPHPNAPDQAAAVSLRLTSAVSLLAKTAHTPVPLAHLHKTLATAFPDAPEEKTTALV
                     EHLLDQRLLLDSAAAPPSPQSALSHGGSDAETVDVRIRATVTVHRNVAQEAARATAVAA
                     RLSPHPEGPPAWADYHRRCLETYGQNARVDLLTLTGPAGLGYPSSYRHTRLPAPPPASG
                     KLDAAFVEAAATAALHGQTELDLDDPTWAHLMARTPKAVPAHAEIRAHLAAASPADVDQ
                     GRYRLWVTGISKGAGTLTGRFAHLDGMDTTVAASGLPTLTQAALPVQVLAPPMADTAAH
                     LCRTPVLAPTVLPIDVHPPTDLDTEVLHPEDLAVRIDPDHLRLVHAPTGRVLEPFHPTA
                     LNVLGYTHPLARFVTELPRARTALYLTCDPWPEPLRRLPFLPRLRAGRTVLAPARWRLT
                     PATWSTARTRTHLPLPRYAALVEGERHLPLDLEDAAHRSLVDTHLYRHGHVILTETPSP
                     EDFAWCDGHAHELVLPIGTTTPPTRLPATVTVRTAVEREATGNAWVSAHLYADPSLFPQ
                     ILAELPALEHRTGDELRFWFVRYRDHHGPHLRLRLHSTGHTALHQAVTSWGHDLVGAGL
                     LHDLALHTYRPEYDRYGHGPVMKVAENAFVHDSRAAIAQHHTTYGDPSQGRALAALSLL
                     RIADAMGADTKWTVAALPRPRNPVDRATLAIARHLLTHPEGLPAPVTATWGERDHVLAA
                     YRKRLDHPLRVVSSLWHMHHNRAHGPDRDDEHDLLALTRSLGLARRHLEHPDDDRT"
     aSDomain        complement(13197..13469)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PWG71_RS10410_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.50E-14"
                     /identifier="RREFam001.1"
                     /label="PWG71_RS10410"
                     /locus_tag="PWG71_RS10410"
                     /protein_end="238"
                     /protein_start="147"
                     /score="44.7"
                     /tool="antismash"
                     /translation="VVLAQTVRVHGERLCLDHRPHPNAPDQAAAVSLRLTSAVSLLAKT
                     AHTPVPLAHLHKTLATAFPDAPEEKTTALVEHLLDQRLLLDSAAAP"
     gene            complement(13998..14207)
                     /locus_tag="PWG71_RS10415"
                     /old_locus_tag="PWG71_10415"
     CDS             complement(13998..14207)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014908230.1"
                     /locus_tag="PWG71_RS10415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10415"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_274809413.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.4e-14, bitscore:
                     45.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLLADRTDTGLVPLGRDRALRTTTTDPFDLDLRVEVPVVDQSL
                     WSMTNDGCGQTCQSACAPSCTDNG"
     CDS_motif       complement(14064..14207)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSTLLADRTDTGLVPLGRDRALRTTTTDPFDLDLRVEVPVVDQSLWSM"
                     /locus_tag="PWG71_RS10415_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13998..14063)
                     /prepeptide="core"
                     /locus_tag="PWG71_RS10415_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-3.20"
                     /molecular_weight="1943.0"
                     /monoisotopic_mass="1941.7"
                     /core_sequence="TNDGCGQTCQSACAPSCTDNG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTLLADRTDTGLVPLGRDRALRTTTTDPFDLDLRVEVPVV
                     DQSLWSM"
                     /leader_location="[14063:14207](-)"
                     /alternative_weights="1961.0"
     gene            complement(14217..15503)
                     /gene="fxlM"
                     /locus_tag="PWG71_RS10420"
                     /old_locus_tag="PWG71_10420"
     CDS             complement(14217..15503)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014910209.1"
                     /locus_tag="PWG71_RS10420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10420"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_274809414.1"
                     /sec_met_domain="PCMT (E-value: 6.9e-36, bitscore: 117.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATSTTDTIRAREAMVDAIVADHTRLGQRSLSWAVEQALRTVPR
                     HTFLPGLPSAEAYDHEQAVVTKEENGLALSSVSAPSIIATMLHRADLHPGQRVLEIGSG
                     GYNAALIRELVGPTGQVTSIDIDPDVIARAERCLADAAVESVHLAVADGEHGFAVRAPF
                     DRIIVTVGAWDLSPAWDAQLAPDGRLVVPMRVRGLTRCLTLERTAAYGHWRAVAVDPCG
                     FVRMQGAGEHWEPMPLLHEPDGAQVGLRLEDGPRPDIDALRTALTTDPAESWSGVTVGA
                     EEATDGLDLFLASVADGWALLTAQRGAIQAGLIRPIVLTGTPALVDTDGASFAYRILRR
                     IPGQEKWEFGAVGQGPHATRVAQQLTDLISRWDGDHRGGPGPHIELFPASTPAADLPPG
                     RVVTKRHTHTVLNWDRRPYEWPDQTHKER"
     gene            complement(15743..16270)
                     /locus_tag="PWG71_RS10425"
                     /old_locus_tag="PWG71_10425"
     CDS             complement(15743..16270)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017563115.1"
                     /locus_tag="PWG71_RS10425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10425"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_274809415.1"
                     /transl_table=11
                     /translation="MADDGREEEPLYVRDPAAWRRTLAEGNRFQARKRVAAKVVLHDEQ
                     GRLLLVDPTYKPFWDLPGGMAEANESPHEAALREVREELGLDLVLGDLLCVEWAPPRDP
                     WDDLLMFVFDGGTLTPERAANLHPVDPEVGDIGWFTPEQASQCLREDVWARTHQALIAL
                     ENKTTVYLTPDR"
     gene            complement(16290..17198)
                     /locus_tag="PWG71_RS10430"
                     /old_locus_tag="PWG71_10430"
     CDS             complement(16290..17198)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037660.4"
                     /locus_tag="PWG71_RS10430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10430"
                     /product="hypothetical protein"
                     /protein_id="WP_274809659.1"
                     /transl_table=11
                     /translation="MEGTTAEAVTAFRLADRRAGGGHLYALVMRYLSSRVGPALVSESG
                     TPTTFVAAAGLTEMAGWMAHDAGRDDVAANHFQRALNLARAGEAGSLTAQIWASRAHLA
                     LHRDDTENALLAAEQAWRQLDGTEDTALRGRALAMLTRAHAARGDATTARTFLRQGEHL
                     LSVPISPPASEWTSPFDLASLASETARSMCDLDDHTAAVEHAHHALNLRSPERVRARVL
                     ASLTLARALIGQHKVDEAAGLVAEAGTAIAEVGSAVASARFQEVRAALASYRNVPAVAT
                     VLSQTGKAPYGSPAPTLNRSG"
     gene            complement(<17346..17756)
                     /locus_tag="PWG71_RS28685"
                     /pseudo=""
     CDS             complement(<17346..17756)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="PWG71_RS28685"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSATVRSHPESWAAICPSCRNRSAQLRRVRWSLVTVVIPALLLPK
                     EPPVCGNCGRPRGEGQGGCTCIPSLMWRDPEVVAAVRDRDARSVIRFLRHHVEDLSQEA
                     LARMCGVAQSTIARAEAGHGLTDRRKAIEALRG"
     gene            17755..18240
                     /locus_tag="PWG71_RS10440"
                     /old_locus_tag="PWG71_10440"
     CDS             17755..18240
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS10440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_10440"
                     /product="hypothetical protein"
                     /protein_id="WP_274809416.1"
                     /transl_table=11
                     /translation="MCANAAWAYAVLDDEKRSLDSLARAHDAFARADSDTTPWVRFFHE
                     ADLDAMSGVVNAALPTPSPRAYTATTEHLYRAVEARSPEMGRSQAFELTTLATAHLRNG
                     DPDQGVRIGHQAVDLARRVRSVRVIDRLAPLQQAALAYRTRGETADLAADIATLRTS"
     gene            18237..19166
                     /locus_tag="PWG71_RS10445"
                     /old_locus_tag="PWG71_10445"
     CDS             18237..19166
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017600951.1"
                     /locus_tag="PWG71_RS10445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10445"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_274809418.1"
                     /sec_met_domain="APH (E-value: 2.9e-11, bitscore: 37.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTPAPSTGPRFALTRDRVHEVLAALCEEAGIGSRAADDAELIK
                     FTNNAVYRLPGAGLVVRIAGSATVAERVPVVIEAARWLARHDAPAVRLVEEIPQPVRAA
                     GATATFWHLVPSTGPEPTGGDLGHILQHIHTLPAPGFALPSWEPFVRIRSRIADAEGLA
                     EADRVFLTERTDHLELQVQDLEFELPAGVLHGDPFMGNLIPGPQGPVICDFDSLSHGPR
                     EWDLTPAAVGKVRMDYPVDHHTPLAAEYGFDVLTWPGFPVLRRLRELRLVTSVLPVLNT
                     SPGLRTQWQHRMNTLRHGDATTRWSTYR"
     misc_feature    complement(19531..19547)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.93"
                     /tool="antismash"
     misc_feature    complement(19547..19561)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.25"
                     /tool="antismash"
     gene            19762..20595
                     /locus_tag="PWG71_RS10450"
                     /old_locus_tag="PWG71_10450"
     CDS             19762..20595
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025022.4"
                     /locus_tag="PWG71_RS10450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_10450"
                     /product="PIN domain-containing protein"
                     /protein_id="WP_274809420.1"
                     /transl_table=11
                     /translation="MTWHFLKNNNDHSLATEKLAGLLQNLRNLIGESNGDPAISSNRYL
                     MWTEEAELRLREIYQDREASQKIHSERYWQIRAISASTHRPHSLIRLEIEDKIDLISAL
                     IDQMEHYRNILTAKENESLILLDTNVLVHGKPFEMVDWQKLAGSKYACLVFPLAVIDEL
                     DKLKDTKQHKARVPLASLDRLISHTNPFQRARARDGVHIQITDEPLGHTRLSRVDDEII
                     RQASYFQSVSGKNLKVITRDRGMKFRAEFSGISAEILPKELERSKTQEGENDGKQ"
     misc_feature    complement(19771..19785)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.26"
                     /tool="antismash"
     misc_feature    19772..19785
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.87"
                     /tool="antismash"
     misc_feature    complement(19773..19786)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    19774..19787
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.53"
                     /tool="antismash"
     misc_feature    complement(19778..19787)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.04"
                     /tool="antismash"
     misc_feature    19828..19830
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20257..20259
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20467..20469
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20582..21229
                     /locus_tag="PWG71_RS10455"
                     /old_locus_tag="PWG71_10455"
     CDS             20582..21229
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS10455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_10455"
                     /product="hypothetical protein"
                     /protein_id="WP_274809422.1"
                     /transl_table=11
                     /translation="MENSRSLSTSVPQDESERIELLIDRPDGWEYLLFGYYLKKFMQEV
                     EPKWRDYHLGYSMSVGPQVDDFSLGNELTDKISKVIKISGNLEKIISRRAQEISFGRPG
                     EPGDPESIKHMGERLMTTYEQLIDWGNEIRSLRVSEDSENLLEIAALFVEQPIKEVRNF
                     TENYINNIEDAMERIANGSTEPISLDMKLTFELPEDLQRNFDDELERLTRGQ"
     misc_feature    20786..20788
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20936..20938
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21312..21959
                     /locus_tag="PWG71_RS10460"
                     /old_locus_tag="PWG71_10460"
     CDS             21312..21959
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS10460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_10460"
                     /product="hypothetical protein"
                     /protein_id="WP_274809424.1"
                     /transl_table=11
                     /translation="MTIAQRVLDFLGKSGRGWDDDELARQLDVSPRQSINQACRKLADE
                     GRLHRYKGPKGKIVNAIGGTQPTDSSMPPGASIEQQHAERIILDAASALLGTRLDPRRI
                     LTPTGVRVEVDGADQNLTVLVEAWAHQGPVKAAQRHKVLSDALKLVWISSTLYPRPRMV
                     LCLSDREAARPFLGERSWAATALRDLGVEVLVIDLPDHISARLRQAQHRQRR"
     gene            complement(22093..23079)
                     /locus_tag="PWG71_RS10465"
                     /old_locus_tag="PWG71_10465"
     CDS             complement(22093..23079)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS10465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_10465"
                     /product="hypothetical protein"
                     /protein_id="WP_274809425.1"
                     /transl_table=11
                     /translation="MSSTPLFSTYRQGENRVTSSMLAVFERIGLSLVEEILAKASGEAT
                     LETVTFTNQPKAGKGSVPDARTSADFTYLFEVKTVRGTVRAKQLRCHLEDLKEGPGRYL
                     FVLTPDAVRPAALDVVVDRRVVWFNFAALYDAITAVVDDAFLAPSERDRFLLRELQALF
                     DNDGLVTSAEVVVVAASQAYPEYLASSAYICQPGRAFREGLTHMGFYAQQAIQPHLARI
                     LTCEDHVPFTYEEVLRREGNGGRDARIGGLIRASLEAGVREEGQEYMVFLLSGPEAPET
                     VVLESPVVNDTVAASGRPWAWTMGQRYVSLAALRRPGVRTTSDLETS"
     misc_feature    complement(23258..23272)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     tRNA            23294..23374
                     /anticodon=(pos:32441..32443,aa:Arg,seq:tct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="PWG71_RS10470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="PWG71_10470"
                     /product="tRNA-Arg"
     gene            23294..23374
                     /locus_tag="PWG71_RS10470"
                     /old_locus_tag="PWG71_10470"
ORIGIN
        1 acacatcgac ggcgaattcc gaggtcagcg tgccctcggg gtcgtcgctg ctcccgtgag
       61 cgaacgtgtg gatacgcacg tacttaccct gccgagatgc ctggtctgcg atggcgaacg
      121 ccgcgcgagc aggatgccca ttggtgggtt cgcgcgaggt ccaagccctg atggtccgca
      181 tgtcctccgg cagtggccaa ctgcgtggct cagcgctggc cggaacgaac gcctcttccg
      241 aacgcatctc gaagctccag ccgatgtctc cgtcactgcg gacctcgttc gagacgcgga
      301 tcccgaatcc catcatgtaa gccgcatcga ggaactcgac cagttcctcg ggattgtcgc
      361 tgaagtagag ctgacggacg acactgatgg gccccatgtc ggtgtagcca tgggggtcag
      421 gcttgccaat gtcgtggaga aaacgacgga cggcagtctg caccggcgcg ggaagccgtt
      481 ccagcacgcc attcacatca tcttctcgcc cttcgaagag gcggagattg agggcatcca
      541 ccagttcctc agtgagcaga gtctggtcgg cggacaaggt ggtgacggcg cggagactgt
      601 gatcgccgtc gacggtgagc gcgaagatac gtgccttggt cggggtgtgg tgggcaatga
      661 atcgttcgat gtacacgaat gtcctctgtg taggccgcac aggcgcacac aagcacgccc
      721 atggagggag gaaaagacta aagaggcgtg tcgaccgagg tacgtgcccg ccgcgttgcc
      781 gttggcccgt gtcagtccgg gtacagcccg gaccgcttgg agcagaaccc cagcattgca
      841 cacccatccg cgttctgaaa gcctacggct gttgagaccg acggcgggcc gatcgaactt
      901 cccgagaccg acccgtacaa cgatgaagtg gaccaggaaa accgggaggc ctacgcccag
      961 aagatccgcg agcggttcgt cgccctggtt cgtgtcgaag ccgaaaacaa ccaggaccgg
     1021 cttctgtgac gcgggagtag cgttctcgcg aggacctcgt gaggtgccat cggacgccgc
     1081 caactgggca tgcgtgctcc gttcgtgctc cgcggttttg gaccggagcg acaccgggcg
     1141 gcacaacatg gcaccgggcg gcacggcgga tcggatgggg tgacacgaaa cggcacgtag
     1201 cgacacgtga cggtacgcga ccagggcact tctcatccga tggccgcagg ttcgaatcct
     1261 gccgggtgcg ccacaaaacc ccaggtcaca ggggtttcac gaggacctcg caagaggtcc
     1321 tcgccgcgtt ccgggccctg aagtgctcca tgtgtgctcc ccagtacaag cccccgtaca
     1381 cccggcgctc cacctccgga gcactttgcc ctcccgtgac cctgcgggtg cgtacccggg
     1441 acgccccgcg tccgcccacc agcgccccac agccgccccg acccccgcgg gggtcggggc
     1501 gcgccctgcc gccaaacagg ccacatacgg ccgattcagc cgaaacctgt accccacagt
     1561 agctcccgag ccacaatcgg ccacatgacc aaggcaaggt ggagctggac agctgcggtc
     1621 ccatcgtgat tctggcctcg ctgggcgcag ggctgtggtt cggaggaggt tccacgacat
     1681 accaatccag tggaagcttg tttcaccgca gcgttgtggt caggctcgcc caacctcagc
     1741 gtgtgcggga gtcaatcagc ccgaagctag gaaacctact ggagcaaatg tggagccagg
     1801 cgagcgacat cccgtagtgc gaaggctggt ccgcgcacgt gcccttcagc ccagatatca
     1861 ccgaaggcac actccaggcc gtcaagaccg aagtgaaagt tcccggcttc accagccctg
     1921 ccgaagcgcg gaggctgggt tgcggtgcgc tgccacatga aatcggccag caagcagacg
     1981 agcggaacat tagagccaca cggtggacct tcacttgcga ccctggatgc ttcccatctt
     2041 cgcatcgtcc tgagtcgtgc accctacccc tcgagggctt tctctagtat cacaaaatta
     2101 ggcaattaac aatacactga ccagcagtgg ccagccacag actcgcagac attctcaatg
     2161 gatcgacatg cgctacccta aaagagtgtc tatgggcgaa tccatccccg atttcattca
     2221 acactggggc ccgagcgtcc ttctagtgat ttctttaacc cttctgcttt cagcaacccg
     2281 gagaaaacca cgctattcgg agccaataga aactcgcaca aaccaagcag caccaagaag
     2341 agcgacctca aaagaaggcg ctctagagga catcagaagg actagcccct acaatctaac
     2401 cgaccacgga ggcccaaaca tacgactcgg cgacgtttcg agattcacgc catcagacta
     2461 cagggcatca gtagccgcaa tatcggaaag attcaaagag ggtcgcgtta tttcgattga
     2521 tctttctgga cttgaagaaa gcgaggccgt cagacttatt gacttctgta gcggaatgct
     2581 ttccttctcc tccggctggt tttttcgaat gaccaagaat gtaatcattc tagtcccacg
     2641 tagttagacg atcacaagaa gggtttcaag ttgacggata gcgcagatga tcagaccacc
     2701 tcagagtcgc caaaatcagc gaacgaagtc cagacatctg gagagaacga aaaacttctc
     2761 ctcctgaatc acgaagtacg cgaagcagaa tttgctctaa atttcgcaca gagaaggagg
     2821 aagtggtcca acctatctct gttcttcggc cctcttctgg ggcttgcctt gtatatcatg
     2881 ctctgggtcc cctggataag cagcgagata aagggggtga tcatgctccc agctgcaccg
     2941 acggccatcg ctttctgcgt ctactcctac cgcctgaaac gagaccccgg aggacctctc
     3001 aactaccaag gagaaaaaga tcacggcggc aaggatgaaa ccgacaggga tgaaccccga
     3061 agccgaagct cgcgccgact aagcgaaggg gaaatcgagc tagtcatctc acagatcaag
     3121 gatgcgcgaa aactactgct cgccaatgca ggcgtttcca tttccgtcag aaggatcacc
     3181 tacaaggaag atgcctactc agaaattgat cagttccgca ccgaaagtag aaaatttagg
     3241 aatgtccaca acctcttgca ggggatcgtt atcatcggct cccttggtgc aactggcatg
     3301 gcggggctcg ttgttcagat ccccgaaatt cgctgggcga tactcttcgt tacatttttg
     3361 gtgggcgttg cgagcggctt catgggttac ttcaaataca aagagaggag tttttatctt
     3421 cagcagactg ccgatgcagt cgaaagcgaa tgggaggccg ttgaaattgg cgtaggcagg
     3481 tacaagcaca tcaaagagga agaggatcag cttgccgagt tcgtagccga ggtacatcgc
     3541 ctgaagtccg agcagaaaaa gaggcagcag aacttggagc aaccccccga gacccgctcc
     3601 gggaacgact aatttcgaag tgaaaaatag aaacccgaaa aaccataagt ctcaccccct
     3661 ctttcctggg aataactact cgaaagattc agggaagaaa tggcgagtct ctcacaaaag
     3721 aggccatcgc cgccactaaa gaaaataatc ccaactccca ggggaccttt gattcgatgg
     3781 ccggccacct ccgcccacgg cgaagcccca ggccaggcgg gatgaacccg ccacgcagcc
     3841 cggggcccgg ggcgctgaat cgctcctggt gtgctccccc gtcccgctac ccgaccgaca
     3901 ccggctcccc gcgcaacagc gcagcggtcg cctcggccgc cgccttggcc acgtcggggt
     3961 acaccgactg gtaggtgtcc tgggtgaagt gcgtggtcgc gtggcccagc tcgacggaga
     4021 ccaccttcac atccgtgccc gcggccaggg cgagcgaggc cgccccgtgg cggagcccgt
     4081 gcaaggtgat gggcgggagc ccggcggctt tggcgatgcg gcagaaccag tcactgacct
     4141 gacctggatg ccagcccgaa ccgtcttggc gggtgaacac caacccggtc tggttccagt
     4201 gcttcccggt ctggaggcgt tgttcgttct ggaacctctt ccacccgcgc aggatcttga
     4261 tggtgtcggc gtccagggtg atggtgcgct gtcctgcggc gctcttgggg gtggaggtga
     4321 tggtctccca ggcgagctgg acgacctgga cgcggatgtc gatctggccg tccaccagcc
     4381 gggtgttcgc ccacggcaac cccaccgcct caccccggcg cagccccttg acggcgatga
     4441 ggtggaacat ggggaacagc cacgtgtacc gcctcgcgtg ctggaggaag gtccgggtct
     4501 gctcgggggt ccagaccatc acctcgccgg gtacggtccc gcccttctcc cactggcgca
     4561 cccggtccgc ggtccacacc agggggcgtt tcctcgggca ggacggaagc cgtacgtgcg
     4621 aggcgatgtt caccgacacc ggtaggtccg gggagcggac cgcgtccgac aacgcactgc
     4681 gcagcgtggc ccggatccga tgcttggtcg acagcgagat cacccgccgc ccccgcaccg
     4741 acctccgcac ctgcgggtcc tcggattcac ggcactccag gatgtgcacg ttcgcctcct
     4801 ccaccttggc gaacatcgcc tccacttgac gggcctgcaa ccgatccaca cggaccttcc
     4861 ccagatgcgg gaccaggtac ttgcggatgt gcccgtcgta ggaggcacgg gttccttccg
     4921 cgaggtcggg cttgccgtcc aaccattcgc gcagccactc ccccgccagc ggaggctcac
     4981 gacgggcatc cacaccagcg ccgatgcgtt tgcggacctc ctccacctcc ggcagaggcc
     5041 ggcgaccctt aagcgcggcc tgaatcaggt ccgcgacatg gatttcaagg tccggctcgc
     5101 cctcggccag ggccaacagc gctttcacgt ggtcgagctg gcgccgggcc tcctcctgag
     5161 tacccaggcc accccttcgg gcttggcgac gcttgccctc accggttcgg ggcagttcga
     5221 gctggaacca ccagttcccg tgcctggggt tccacgcccc gtcctcccgc cgcaatcgcg
     5281 ggcacttcac ccccaacgcc cggccgctgt tctcctcccg acacccgcac cgcttgaaca
     5341 ccgacccctc gtacgcggtc atcgatgccc tcacctttct tccgtggcat tcacgcgcgc
     5401 accgcacccg cacccgtcag tggtggcggc cgaggtcgcc ggaaggttca ggccgagata
     5461 ggccagcacc ccggcagtgg ggatcaccca actgcgcccc accctctgca cagggaccgg
     5521 gaaggcctcc tcgcggagga gccggtagac ggtggtgcgc cccagcccga gcaaccgccc
     5581 cgcctgaacc ggactcaggg ccaccggcag cgaggtgatc tcggccagcc tcaccggagc
     5641 atcccgattc accgcaccca cctcctcccc acctctgaac tgcacgaaca cgccgcgcga
     5701 ccccgcgtcg tgcggggcac tgtgcatcca cgctcgacct cgccgagcaa tgcaagcgga
     5761 ttggccagaa cacccaccgg acccgcgctc cacccggcgg gcacactcga aaacgggcac
     5821 catgtccgat tccgcggagg cggcccacag tggccgcgtc cgcccccgaa cccgcagcac
     5881 cgcccccacc cggcctgtcg ccggtttccg ggccgtgtgg gggcgctgaa cgccgcacaa
     5941 ccgccccgcg ccgcccgcga acgccgacgg ccgcgcactc ccagcagagg gcgcgggcca
     6001 cgggcgcacc cggagaagtc gtaccgggaa cccctgggtg tgggttctgc ttctcttttt
     6061 ctcttcatgt cctatgagga aggtgctccg gcccctcgat gcgacaccga acgaggagca
     6121 gtccagcgac acgctcccgt ccgccaggag cagcgccccg gcgcgcggac caggtggagg
     6181 cccgcgcacc gtctcggcgt atgcatcagc ctcctcgttc tggtacgtcg accaccgccc
     6241 cgaaccggtc gctttgaagc aggagtgttc ttccaagaga ccgaggacag ggacgcagag
     6301 cgatgaaggc aacaggagcg agaggcgacc cgcacggcgg agcgcggtcg agggcacaga
     6361 ccgatccgcc gtcctgtcgg ggggtgcccg ccgccctacg tgaagtcgac cacccactgg
     6421 gtaggagtct ggacccgcga gacacactca aatacgctgt gagctgcaag aatgcgcgat
     6481 atccgggcgg ttgtgcccct gggggcaccg gcgtggccac acgcgcaggc aagggcgtag
     6541 tcacaggcgt agtcacacgc acggccaccg gcgtagtcac aggaaccccc ttcaagcggg
     6601 aatgtcacca cgcccgagaa cccgacgcac ccctcttgtc gctcggtccg accagaccgg
     6661 cggtctccct acgctcggga tcttccgccc ccggaccgcg tcagcgagga gtcctcgcac
     6721 agcccgcccc gatccgccag gagcagtacc ccggcgcgcg gaccaggtga cggccagcgc
     6781 accgcctcgt gtgtgcatca accacctcga cctggcacgc caccaccccg gaacggtcgt
     6841 tttccagcgt tttcgagaat gtgttttcga gagaccaagt ccagggaatg cagagcgctg
     6901 gagaaaacag cacaagggga ggcgacccgc atggaagtgc gccgccgagg ggcgcggtcc
     6961 gagatccgcc gccctcgggg ccgccccgcc ctacgtgaag aggaactgcc cacttgggta
     7021 tgtgtctgga ttgcgaaagg cccacccgga gcggcttcga cctgcactga taacgcgcac
     7081 agggtgggcc gttctaatag gcccacccat cgacccggtc acaggccccc cgaagggccc
     7141 agtcacaggc ccaccccgca aaagccacaa aaccgacacc ccgagaagcc caaccaccgc
     7201 cccgacttcc cggaaagcaa ccaggaatgc tttcctcgca gccattgatc gacgaatacg
     7261 ggagggcact cgagggagca aagaaaagca ctgaggagcg tcccctccca caggagaaga
     7321 cgcccacagt tcgttcacgg cgttctcatc cccgcagcgc caggtaggcg cggatgcggt
     7381 cggccagctc cgcgaactcc tcctcgtcgg ggaccggggg cgtggccggg tagtccttcg
     7441 gctcggccgg gcgggggcgc ggaacggagc cgaggttgag gtaggggcgc accagagcac
     7501 ccgcgaccag gtcggggtcg acgtccaccc ggtcctcagc ctcgaacggg gcggagcggt
     7561 cacggtaggc ctgctcccaa cgggccgagg cggcggacac tccgctctcc caaacgtgct
     7621 gttcggggaa accgaggtgg tcggcgagca ggtcgccctt cctggaggcg gtgacggacg
     7681 ggggtgctgc gggcagtgcg cgcgggaccc ggcggggcaa ccggggcggg cgggggtcga
     7741 agagtgcggc cagggcggtg gccagcagcg cggcggtcag cgcccacaca cgcccggcca
     7801 tgctgtcgca gggccgcctg tggcgaccgg tagtagggtg ttccacggtc tcctcctggt
     7861 cggttcaggt ggtgatcgcg ccccggcccg gtgttcgcgc accggtcggg gcacctgtgt
     7921 ttttcagttg cagaggtggc ctctcgtgcg ggtgtcattg accccgcagt gctgcgcttc
     7981 ccgcaccttc gagcacctca cgaaggcgtc gcccctgttc ttggaggcct tggttcttct
     8041 caggaagcct gggtccaccg gttgtcggtg aggtcgtagg cgaggaagaa ccacacctgc
     8101 cgcaggtccg cgatgccgtt gtcaccccag ccggtggcca gggcgtcgag catggccagc
     8161 ccacgaccgt gctcggcctc gggggccagc ctttgcgggt cgggaaccag gtggtgggtc
     8221 tcccccgccg gggtggtccg gcccgaggcg tcgccctggt cggcgcaggt caggtggagc
     8281 ccgttgcctc ggcgtcggca ggtgagggcg tagcggccgt gggggtgccc ggagcgggaa
     8341 tgggtcaggg cgttgttgac cagctccgag ccgagcaggg tgaacaggta ccggtagtcg
     8401 gcgtcgcggt gggccgcgca ggtgttgagg aatgcgcgta ccagcggcag gagttcgagg
     8461 ctggacccga actcgtagcg gcgggtggtg taggcgcccc ggtcgggggc gtggtggaag
     8521 tagtgccggg cccgggcggg gaccacgtcc cacagcggca gggtggcctg cggcagcggc
     8581 gggagttcag tggtgcccgg gtcatggggg cctacggcgc tcatgggaac catggcgcga
     8641 ttcctttctc agagaagaac gttcaggtcg gcccatcggg gccggccaac gcaagcggtg
     8701 ggcaacccgg catccgctcc cccaacagtg ggagcgaccc ggcgggctga gtcaccgcac
     8761 caccagcatg cacgactcga ttacgttcag caatgttttc tgagagaaaa atttacgcac
     8821 aggaactatg gcattctggg gccaagccag ctgcggcccg accagagagg gccgtctccg
     8881 cgatcatgac caccaggagc tttcgtgccc gacgaaccgt ccctgcgcca gcgctggttg
     8941 ggaacccacc tggaagccct gcgccgcgaa gcgggcttct ctctccagga ggcctcgcgc
     9001 gcggcccagc ggtcgacggc ttctctcagc cgcatcgaga acggtgtcgt cgctctcccc
     9061 gcgcgcgacg tgcgtcccct gctcgacgcc tacggggtgg aggaccgtga cgcccgggag
     9121 accctgatcg ccgtcgcggg cgaagtggag gccgagcgca ggggctggtg ggtcgagcac
     9181 agcgacaccc tgtccccctc ctacctcgac ctgctccgtc tggaggcgac ggcgtcggag
     9241 gtgcgcacct acgagaccag cgtgatcccg ggcctgcttc agcacgagga ctacgccagg
     9301 cgggccgtgg ccctcaccag cagcacggcg ctgagcgagg acgccttgga gcggttcatc
     9361 gccgtgcgca ggcagaggca gcggatcctc caccgggccg aggaaccgac cgccctgcac
     9421 gcggtcatcc acgaagccgc gctccaccag accctggacg cccccgaggc gctggcgcag
     9481 cagctggagc tgctgcggga gttgatgtcc caccctctga tcaccgtgca ggtcctgccc
     9541 ctgtccgctc cccacccggc cttggccggc gcgttcaccc tggtggagac gcaccgtctg
     9601 acctgggtac acgtggagtt gcagaccagt gacgtctact tggaggctcc gcagagcgtc
     9661 gtcccctaca tggcctgctt caaggtgctc tccgagcggg cgctttcgcc caccgagtcc
     9721 gtcaaggcga tcaacgcgag gctcgacgcc ctgacaccct gacgtccacc ggctctaccg
     9781 cagaatgatg atcatgaaca gcacactccg ttcttcctgg tacaagagca gctacagcac
     9841 ggcgcagtcg aactgcgtcg aggtggccga gagcgtggcg gggaacgctg tacgggactc
     9901 ccagcacccc gaactcggac atctggactt ccccgccgag gagtggttcg ggctgctcgc
     9961 cccgctcaag cagcgagtga accggtagcc cctaccgcgt tcagacgagg agcaggcagc
    10021 ggtcccaggc cagggccgat gctctgcccg ccagcgccat ggtggtcccc tcttttcctt
    10081 ccagcagccc cgattcccgg tgcgggaacg gggccgcggc gtgttcgcgt acggccggta
    10141 gatgccgttc caaccgttgc tccggtcgaa ctgcgggctg gtcttcggac atgcggcgaa
    10201 ggacttggag cagtccggcg gggccgtggc acaggccgcc gtcggtgaag tggttcacga
    10261 ggcggggatc ggacaggcag gtgtccatgg cctgttcggc gtggaggcgg cgaggggtgt
    10321 ccccgagggc cagggcggcg agctgccggg ctcgggcgat gcccggggtg ccgtagcacc
    10381 aagagggcgg gcctggcctg gtgagcggcg cggggtggcc ggtggagacc catccaggcc
    10441 accaggtgcg ctctccgtcg tggtgctcgt gctcgtccag cgcggcgcac agccgctcca
    10501 gcgcttcggt gtgtccgtcg acggtgcgtc cgtctcggtg ggtgagggcg aggaagccca
    10561 gtactccgct gatgccgtgg gccaggccca ggttggcgtg cccctcggga aagtccgggt
    10621 ccgggtgtgc ctggggtccg tggtggaccc accatccggg tcgttcgtgg tgctcgtggc
    10681 gaatcgggcg ggtgagccgc accaggtagc gcagaaggtc atcaagaagg tcgccgtcag
    10741 ggtcgatgct gcggagggcg acgccgatgc cggtgagtcc ggtgatgagg tcgtactcgg
    10801 cgaaggaggt gagacgtccg tcctcgatgc gccgggtcgc ggccgccagg cggtggcggg
    10861 tgagggcgat caggtgctcg cggacggtgg tgcgggcgct gcggtaaccc tcgggagggg
    10921 tcagggaaag aaggaaggcg accgcgggca gcccgtggaa cagggtgttg cggctggctg
    10981 ggtcgatggg gccgtcggcc agcgccgtgc gtaggagggt gtgcacggtt tcgggtgggg
    11041 agccggtggc caggtacagc agggccgttc ccagcgttcc gccgttcagg gacagcggcg
    11101 acgtgtccgt ggcggtgagg atgctgtcag gtgcggtcat cgtcggggtg ctccaggtga
    11161 cggcgggcca ggccgaggga tcgggtgagg gcgagcaggt cgtgttcgtc atcgcggtcg
    11221 gggccgtggg cacggttgtg gtgcatgtgc cacagggacg acacgacccg cagcgggtga
    11281 tccaaccgct ttcggtaggc ggccaggacg tggtcgcgtt caccccaagt ggcagtgacc
    11341 ggggcgggaa ggccttcggg gtgggtgagc aggtgtcggg cgatggccag ggtcgcgcgg
    11401 tccacggggt ttcgggggcg gggcagggca gcgacggtcc atttggtgtc ggcgcccatg
    11461 gcgtcggcga tgcgcagcag ggacagggcc gccaaggctc gaccctggga agggtcgccg
    11521 tacgtggtgt ggtgttgcgc gatggctgcg cgactgtcgt ggacgaaggc gttctcggcg
    11581 accttcataa cggggccgtg accgtagcgg tcgtattcgg ggcggtaggt gtgcagggcc
    11641 aggtcgtgga gcagtccggc accgaccagg tcgtggcccc aggaggtaac ggcctggtgg
    11701 agggcggtgt ggccggtgga gtgcaggcgg agtcgtaggt gcgggccgtg gtggtcgcgg
    11761 tagcgcacga accagaagcg gagttcgtcc ccggtgcggt gttccagagc ggggagttcg
    11821 gccaggatct gggggaacag ggacgggtcg gcgtacaggt gcgcggagac ccatgcgttt
    11881 ccggtggcct cgcgttctac tgcggtgcgg acggtaacgg tggccgggag tcgtgtgggt
    11941 ggtgtggtgg tgccgatggg gaggacgagt tcgtgtgcgt gcccgtcaca ccaggcgaag
    12001 tcttcggggg acggtgtctc ggtgaggatc acgtggccgt gtcggtagag gtgagtgtcc
    12061 acgagggagc ggtgggcggc gtcttccagg tccaggggca ggtggcgttc gccttcgacc
    12121 agtgccgcgt aacggggtag cggcaggtgg gtacgagtgc gggcggtcga ccaggtggcg
    12181 ggggtcaggc gccagcgggc cggcgccagg acggtgcggc cggcgcggag ccggggaagg
    12241 aacggcagcc gacgcagcgg ttcgggccaa ggatcgcagg tcaaatagag cgcagtgcgg
    12301 gcgcgcggta gttcggtgac gaaccgggcc aacgggtggg tgtaacccag gacgttcaac
    12361 gcggtggggt ggaacggctc cagcacccgc ccggtggggg cgtggaccag ccgcaggtga
    12421 tccggatcga tgcgaacggc gagatcctcg gggtggagga cctcggtgtc gaggtcggtg
    12481 ggcgggtgga cgtcgatggg cagcaccgta ggggcgagaa caggtgtcct gcacaggtgg
    12541 gcggcggtgt cggccatggg cggggcgagt acctggaccg ggagagcggc ctgggtgagg
    12601 gtcggcaggc cggaagcggc aacagtggtg tccatgccgt cgaggtgggc gaagcgtccg
    12661 gtgagagtgc ccgccccttt ggagataccg gtgacccaca gccggtagcg gccttggtcc
    12721 acgtcggccg gtgaggcggc ggccaggtga gcacggatct cggcgtgggc ggggacggct
    12781 ttcggtgtgc gcgccatcag gtgtgcccag gtcgggtcgt ccaggtccag ttcagtttga
    12841 ccgtggagtg cggcggtggc cgcggcttcc acaaaggccg cgtcgagttt cccggacgcc
    12901 ggaggtggtg cgggaaggcg cgtgtgccgg taggaggagg ggtagcccag gcccgccggg
    12961 ccggtcaggg tgagcaggtc gacccgggcg ttctggccgt aggtctccag acagcgccgg
    13021 tggtagtcgg cccaggcggg cgggccttcg ggatgtggag acagtcgggc ggcaacggcg
    13081 gtggcgcggg ccgcttcctg tgccacgttc cggtgaacgg tgacggtggc gcggatacgg
    13141 acatcgaccg tctccgcgtc cgagccaccg tgggacaagg cgctctgagg tgaaggcggt
    13201 gctgccgccg agtcgaggag caggcgctgg tcgaggaggt gctccaccag agcggtcgtc
    13261 ttctcctcgg gagcatcggg gaaggctgtg gcgagtgtct tgtgcaggtg tgcgagcggg
    13321 accggcgtgt gcgctgtttt cgccagcagg gagacggccg aggtcagccg cagtgagacg
    13381 gcagcggcct ggtcaggggc gttcgggtgg gggcgatggt ccaggcacag gcgttcccca
    13441 tggacgcgga ctgtctgcgc cagcaccacg gatcgctcca cttctccact ggcttgcgag
    13501 aactggcccc gtgccttccc tgtcccgagc cggggtacct cctggtgagg tccatgccag
    13561 gtcacggagg tctcagctcc caaggtgaga ggggcgactc cggcgaacag cccgaacggt
    13621 gtcgcccggc agtgggcacg cagcaggtac cgcaccaccg tgaaggcggt gcgccgtacc
    13681 cgcgcctcct ctagctgatc gggggcggcc atgcgctgca cggctgcgtc cagggaggga
    13741 ctggcgatgc gcagcgccct catcagttcg cggtcgtcgc cgaggccggt gatccaagcg
    13801 cgcagctcgg ccggtgaccc ggtggcaggg tcggggtagg caggaagacg ggtccgcagt
    13861 cgagtcgctg cacgtaggga gggggtgatc gtggcgagag gggcgtacat ggtgctccgt
    13921 tccacgtcat cgggggcgaa cgaggggcgc gccccacccc gttgaggtga aagggcgcgc
    13981 cccggtgcga aagtggatca gccgttgtcg gtgcaactgg gcgcgcaggc ggactggcag
    14041 gtctggccgc agccgtcgtt ggtcatcgac cacagggact ggtccacgac cgggacctcc
    14101 acccgcaggt ccaggtcgaa cgggtcggtc gtcgtggtgc gcagggcgcg gtcgcgtccg
    14161 aggggcacca gtccggtgtc ggtgcggtcg gcgaggaggg tgctcatgga agggctctac
    14221 ctttctttgt gggtttggtc tggccattcg tagggtcggc ggtcccagtt caggaccgtg
    14281 tgggtgtgac gtttggtcac gacccgccct gggggcaggt cggcggcggg agtggaggcg
    14341 ggaaacagct cgatgtgcgg gccggggccg ccccggtggt cgccgtccca gcggctgatc
    14401 aggtcggtca gttgctgggc gacccgggtg gcgtgggggc cttggccgac ggcgccgaac
    14461 tcccacttct cctggccggg gatccgacgc aggatgcggt aagcgaagct cgccccgtcg
    14521 gtgtcgacca aagccggggt gccggtcagg acgatggggc ggatcaaccc ggcctggatc
    14581 gccccgcgct gggcggtcag cagcgcccaa ccatcggcca ccgaggctag gaacaggtcc
    14641 aggccgtcgg tggcctcctc ggctccgacc gtcaccccgg accaggactc ggcgggatcg
    14701 gtggtgaggg cggtgcgcag tgcgtcgatg tcgggccgcg gcccatcctc caggcgcagg
    14761 cccacctggg cgccgtcggg ttcgtggagc aggggcatgg gttcccagtg ctcgcccgcg
    14821 ccctgcatgc gaacgaaccc gcacgggtcc acggccacgg ctcgccagtg gccgtaggcg
    14881 gcggtgcgtt ccagggtgag gcagcgggtg agtccgcgta ctcgcatcgg gacgaccagg
    14941 cgcccgtcgg gggcgagctg ggcgtcccag gctggggaca ggtcccaggc cccgacggtg
    15001 acgatgatgc ggtcgaacgg ggcacggacc gcgaagccgt gttctccgtc tgcgaccgcc
    15061 aggtgcacgc tttcgacagc agcgtcggcc aggcaccgtt cggcgcgggc gatgacgtcc
    15121 gggtcgatgt cgatggaggt gacctgaccg gtgggaccga cgagttcgcg gatcagggcg
    15181 gcgttgtagc cgccggagcc gatctccagg acgcgctggc ccgggtgcag gtcggcccgg
    15241 tgcagcatgg tcgcgatgat cgagggtgcc gagaccgagc tgagggccag cccgttctcc
    15301 tccttggtga ccaccgcctg ctcgtggtcg taggcctcgg ctgagggaag ccccggcagg
    15361 aacgtgtgcc ggggcacggt ccgcagggcc tgctccacgg cccaggacag ggatcgctgc
    15421 ccgagccggg tgtggtcggc gacgatggcg tcgaccatcg cctcgcgcgc ccggatcgta
    15481 tcggtcgtgg aggtggcgga cacaggggtc tcccaacgat cggcggatgc cgacgaccga
    15541 ccacaagggc cgtgccgttc ggcgggacag ggacggttgc agtgtcccgc gccggagggt
    15601 gacgacctat gcgcacgcgc atattctcca tgttcgattt atgcgcggtg ttcgattcag
    15661 ggggtctcgc ttggggcgac gacctgacca acgcagttgg ggtgcggacc gccgatcggg
    15721 ctgaacctgg tggtggaggt gctcatctgt cgggggtgag atagacggtg gtcttgttct
    15781 ccaacgcgat cagagcttga tgggtgcggg cccagacgtc ttcgcgaagg cactgtgacg
    15841 cctgctcggg ggtgaaccat ccgatgtcgc cgacctcggg atccaccggg tgcaggttcg
    15901 ctgcgcgctc gggggtcagt gttccaccgt cgaagacgaa catgagcagg tcatcccagg
    15961 ggtcgcgggg cggggcccac tccacgcaca gcagatcccc caggacgagg tccaggccga
    16021 gttcctcgcg cacttcgcgc agggcggcct cgtgcgggga ttcgttggcc tcggccatgc
    16081 caccgggaag gtcccagaag ggtttgtagg tgggatcgac cagtagcagg cggccctgtt
    16141 cgtcgtgcag gacgactttg gcggcgacgc gcttgcgggc ctggaaccgg ttgccctcgg
    16201 caagcgtgcg gcgccaggcc gctgggtcgc gaacgtagag gggttcttct tctctaccgt
    16261 cgtcggccat cgtgtacccc ttcgcctgtt cacccgctcc ggttcaaggt cggtgccggc
    16321 gacccgtatg gagctttccc cgtctgggac agcacggtag cgaccgcagg aacgttgcga
    16381 taagaggcca acgccgcacg cacctcctgg aagcgggcgc tggccacggc cgaccccacc
    16441 tcagcgatcg cggtccccgc ttccgcgacg aggccggccg cctcatccac tttgtgctgg
    16501 ccgatcaaag ctcgggccag ggtcagggag gcgagcacgc gggcccgaac ccgttcgggg
    16561 gaacgcaggt tcaaagcgtg atgggcgtgt tcgacggcgg cggtgtggtc gtccaggtcg
    16621 cacatgctcc gggccgtttc actggccaac gatgccaggt cgaaggggct ggtccattcc
    16681 gaagcgggtg gggagatcgg tacggacagc aggtgctctc cttgacggag aaaggttcgg
    16741 gcggtggtcg cgtctccgcg ggcggcgtgg gcacgggtga gcatggccaa tgccctgccg
    16801 cgtagcgcgg tgtcctcggt gccatcgagt tgtcgccagg cttgttcggc ggcgagcagc
    16861 gcgttctcag tgtcatcgcg atgcagtgcc aggtgggcgc gactggccca gatctgtgcg
    16921 gtgagggaac ccgcttctcc ggctcgggcc aggttcaacg cccgttggaa gtggttggcg
    16981 gcgacgtcat cgcggcctgc gtcgtgggcc atccacccgg ccatctccgt cagccccgcc
    17041 gcagcgacga aggtggtggg ggtaccgctt tccgagacca aggcaggacc gacccgggag
    17101 gagagatagc gcatgaccag cgcgtagagg tggccgccgc ccgcgcgccg gtccgccagc
    17161 cggaaagcgg tgacggcttc ggcggtggtt ccctccacaa cgttccgcca cagagaaccg
    17221 agagcagcgg aaccgtcaac accagcccct gcaccgatgt ccgtctccag cgttggcgac
    17281 tcggtagagc tgatggctcg gggctgagga aggtgaggtc cttccgtttt caacggtgcc
    17341 ccgagtcctc gaagggcctc gatggctttg cgtcggtcgg tcagcccgtg gcccgcttca
    17401 gctcgggcga tcgtgctctg ggccaccccg cacatccggg ccagcgcttc ctgtgatagg
    17461 tcctcaacgt ggtgtcgcag gaagcggatc acactccgag catcacggtc tcgaacagcg
    17521 gcaacgacct cagggtcacg ccacatcaag gacgggatac aggtgcagcc tccttgtcct
    17581 tcgccgcgtg gacgaccgca gttaccgcac acagggggct cctttggaag gagaagcgca
    17641 gggatgacca cagtaaccaa actccagcga actctccgga gctgagcact ccggttcctg
    17701 caactgggac agatcgccgc ccaggactcc ggatgcgagc gcaccgtggc gctcatgtgc
    17761 gccaacgcgg catgggccta cgccgttctc gatgacgaga agcgttccct ggactccctc
    17821 gctcgggccc acgacgcctt cgcccgcgcc gattcggaca ccacaccgtg ggtgcggttc
    17881 ttccacgaag ccgacctgga cgccatgtcc ggggtcgtca acgccgcact ccccacaccc
    17941 tcgcctcgtg cgtacacggc cacgaccgag cacctgtacc gggccgtgga ggcccgcagc
    18001 ccggaaatgg ggcgcagcca ggccttcgag ctgaccaccc tggccaccgc gcacctgcgc
    18061 aacggcgacc ccgaccaagg agtccgcatc ggccaccagg ccgtcgacct cgcccgccgc
    18121 gtccgctccg tgcgcgtcat cgaccgcctc gccccgctcc agcaagcagc cctggcctac
    18181 cggacccgag gagaaaccgc cgatctggcc gccgacattg ctacccttcg cacatcatga
    18241 gcaccactcc cgccccctcc accggccccc gcttcgccct cacccgcgac cgcgtccacg
    18301 aggtcctcgc agcgttgtgc gaggaggccg ggatcggctc ccgtgcggcc gatgacgccg
    18361 agctgatcaa gttcaccaac aacgccgtct accgcctccc gggggcgggg ttggtggtgc
    18421 gcatcgccgg atcggcgacc gtcgccgagc gagtccccgt ggtcatcgag gcggcccggt
    18481 ggctcgcccg gcacgacgcc ccggcggtgc ggttggtcga ggagattccc caaccggtcc
    18541 gggccgccgg tgccacggcg accttctggc acctggtgcc ctccaccggg cctgagccga
    18601 ccggcggcga cctcgggcac atcctccagc acatccacac cctgcccgcc ccggggttcg
    18661 cgctgccgtc gtgggagccg ttcgtccgca tccgcagccg catcgccgat gccgaagggc
    18721 tggccgaagc cgaccgggtc ttcctcaccg agcgcaccga ccacctcgaa ctccaagtcc
    18781 aggacctgga gttcgagctc ccggccgggg tgctgcacgg cgatccgttc atgggcaacc
    18841 tcatccccgg cccccaaggg ccggtgatct gcgacttcga cagcctcagc cacggtcccc
    18901 gcgaatggga cctgaccccc gctgcggtcg gtaaggtccg catggactac cccgtggacc
    18961 accacacccc actcgcggcc gagtacggct tcgacgtcct cacctggccc gggttccccg
    19021 tcctgcgccg actccgcgaa ctcagactcg tcaccagcgt cctcccggtc ctcaacacca
    19081 gccccggcct acgcacccag tggcaacacc gcatgaacac cctccgacac ggggacgcca
    19141 ccacccgctg gtccacctac cgataggcag cgccggatgc gtcgggtgac aggaggcgat
    19201 cccggcgcac cacagcctcg accagactcg gcaagaacgc tgtccaaggc gtcatcacca
    19261 gcgttggtcc gaacgacaac agaatggtct ggtagagccc aaaccacgct tcaaggaccg
    19321 agatagacga cgtgctgcct tcgttcggca aggtcccaga gtcaaaggca caggtccaga
    19381 ggaaccacag ccccgaggac cgtcgttcac tgagatgggc cactctgagc ccccattcct
    19441 ccgcttgcac tgcgtgggac agcaggtcaa cagctatcca acctcggaga cgggggttcc
    19501 agcagagcac ggcatccagg aacctaagca tgcccatatt ttaggcttcg caagtcgaga
    19561 acccatggct acactgtcat gaaaacatga ggcaagaaac cacccaaacc aatacacccc
    19621 agaaagcgac atacggacaa aaaggcacac aaaagacatc aaggctgaaa gcagaaaact
    19681 cgagcagctc aagagaaaat cagagagaac agacaaccca atccaacaca aagatctcca
    19741 ccaaaaagaa acaaagaaaa aatgacttgg cattttctca aaaataacaa cgaccactca
    19801 ctggccacag aaaaactcgc cggcctgtta cagaacctca gaaacctaat cggggaatcg
    19861 aacggagatc cagcgatttc ctctaacaga tatctgatgt ggacagaaga agccgaactg
    19921 agactgaggg aaatttacca agatagggaa gcttcacaaa aaattcactc tgagagatac
    19981 tggcaaatcc gagccatctc cgcctccaca caccgaccac actcgctcat ccgcctagag
    20041 atcgaagata aaattgatct catttctgca ttgatcgatc aaatggaaca ttataggaat
    20101 attctcaccg ccaaagaaaa tgaaagtctt atcctattgg acaccaacgt cctagtacac
    20161 ggaaagccat tcgagatggt ggactggcaa aaactagcag gatccaaata tgcatgtctc
    20221 gtatttccct tggcggttat agacgagcta gataaattaa aggacaccaa acaacacaag
    20281 gcacgagtcc ctctagcatc tttggatcgc ctaatttctc acacaaatcc ctttcaaaga
    20341 gcgagagcaa gagatggcgt acacattcaa atcacagatg aaccccttgg gcacacccgc
    20401 ctctcccgag tagacgacga aataatccgt caggcgtctt acttccaatc cgtttccgga
    20461 aaaaatttaa aagtaatcac gcgagacagg gggatgaaat ttcgagccga attctcagga
    20521 atctctgcag aaatactccc caaagagcta gaacgatcca aaacccaaga aggggaaaac
    20581 gatggaaaac agtagaagcc tctccacgag tgtcccccaa gacgaaagtg agcgaataga
    20641 actgctcatc gatcgacccg acggctggga gtacctccta ttcgggtact accttaaaaa
    20701 attcatgcaa gaggtcgaac ccaagtggag ggactaccac ttgggctaca gtatgtccgt
    20761 aggaccccaa gttgatgact tttctttagg aaacgagcta accgataaga tatccaaagt
    20821 tataaagatt tccgggaacc tggagaaaat tatatcgagg cgtgcccaag aaatttcttt
    20881 cggtcgccct ggcgaacctg gagaccccga atccatcaag cacatgggcg agcgcttaat
    20941 gaccacatat gagcagctaa tagactgggg caacgagata cgatctcttc gggtttcaga
    21001 agattcagaa aatcttctgg aaatagctgc actgttcgtt gaacagccaa tcaaagaagt
    21061 tagaaacttc acggaaaatt atattaataa tatagaagac gcaatggaaa gaatcgccaa
    21121 cggaagcact gagcccatat cacttgacat gaagcttacc tttgaactcc cggaggatct
    21181 ccagcgcaac tttgacgacg aactagaaag attgacacgt ggtcaataac agattctctc
    21241 gtcacctgat ttgatttgtc ctgggaacgc ctgcttctcc gcccgcacgc acctgcatcc
    21301 aggagtccac cgtgacgatc gcccaacgcg tcctcgattt cctgggcaag agcggacggg
    21361 gatgggatga cgacgaactc gcccgccagc tcgacgtgtc tccccgccaa agcatcaacc
    21421 aggcatgccg caaactagcg gacgaggggc gtctgcaccg ctataagggc cctaaaggca
    21481 agatcgtcaa tgccatcggc gggacacagc ccaccgattc ctccatgcca cccggcgctt
    21541 caatcgaaca acagcacgct gaacgcatca tcctggacgc ggccagcgcg ctgctcggaa
    21601 cccggctgga ccctcgcagg atcctcacgc ccaccggggt tcgggtggaa gtcgatggag
    21661 ccgaccagaa cctcacagtg ctcgtggagg cgtgggcgca ccaggggccc gtcaaggccg
    21721 cacagcgcca caaggtcctg tccgacgcgc tgaagctcgt gtggatctcc tccacgctct
    21781 accccaggcc gcgcatggtg ctctgtctgt ccgaccggga ggcggcacgg ccttttctcg
    21841 gcgaacgctc atgggctgca accgccctgc gggacctggg agtcgaggtc cttgtcatcg
    21901 atctacccga ccacattagt gctcgcctgc gccaagccca gcaccgccag cgccggtaga
    21961 agcttcgtcc ttgcggcagg cctgggccgg ttctcctatt ggcccttacc cgaacgctca
    22021 tgcgggggcg agaggcgacc agcagcctgt tcagcggcaa caccagaccg gcccctggcc
    22081 ggtatggaat ggtcaggagg tctcaaggtc gctggtggta cgcaccccgg gcctgcgcag
    22141 agcggccagg gacacatacc gctggcccat cgtccacgcc cacgggcgcc ccgaggcggc
    22201 caccgtgtca ttgaccaccg gcgactccaa caccacagtc tcaggggcct ccggccccga
    22261 gagcaggaac accatgtact cctgcccctc ctcacggacc ccagcctcca aggaggcacg
    22321 gatcaggcct ccgatacggg cgtccctgcc gccgttgccc tctcgtcgca gcacttcctc
    22381 atacgtgaag ggcacgtggt cctcgcaggt gaggatgcgg gccaggtgcg gttggatggc
    22441 ctgctgagcg tagaagccca tgtgggtcag cccttcccgg aaggcccggc caggctggca
    22501 gatgtaggcc gaggacgcca ggtactccgg gtaggcctgg ctggcggcca cgaccaccac
    22561 ctcggcagaa gtcaccaggc cgtcgttgtc gaacagcgcc tgcaactccc gcagcaggaa
    22621 ccggtcgcgc tcggagggtg cgaggaaggc gtcgtccacc acggctgtga tggcgtcgta
    22681 cagggctgcg aagttgaacc acaccacacg cctgtcaacc acaacgtcga gcgcagcggg
    22741 ccttacggcg tcgggtgtga gcacgaacag ataccggccc ggcccttctt tcaggtcctc
    22801 caggtggcaa cggagctgtt tcgcgcggac cgtgccgcgg acggtcttga cctcgaacag
    22861 gtaggtgaag tccgcagagg tccgcgcgtc gggaaccgat cccttaccag ccttgggctg
    22921 gttggtgaag gtgacggtct ccagcgtggc ctcgcccgag gccttggcca ggatctcctc
    22981 gaccagggat aggccgatcc gttcgaagac cgcgagcatc gacgaggtga cccggttctc
    23041 gccctggcgg taggtggaga acagcggtgt ggacgacacg ggaacaacct ccaacgcaca
    23101 tggatcgacc tacctgcccg accagaagac caaggtcgct tctgatattc aaggacctcg
    23161 cgaggtgcca tcggacgccg cccaccgccc gttcgtgctc cgttggtgct ccgcagttcc
    23221 gtactggcac gacatcgggc ggcatctctt gacacgaaac gacagcggtg atcggatgga
    23281 tagggacgaa acggcactcc gtggcacgta gaggcacgaa gacaccggac ttctaatccg
    23341 atggccgcag gttcgaatcc tgccgggtgc gccacaaaat cccagttcaa aggggttaca
    23401 cgaggacctc gccgcgttcc gggccctcaa gtgctccata cgtgctcccc agtacaagcc
    23461 ccagtacaag gcggcaccca cctccggagc actttgccac cccatgaccc agcagggccg
    23521 cgcccgggga cggtcccgtg tccgccccac agccgccccg acgccaccgt gtgggcccgg
    23581 ctggacccag gcacgccctg tcgccccaca ggaccggttg tggccgtttc agtcgaaacc
    23641 ccttacccca cagcggttcc cacgccacaa tcgggtgaca caaccaacca acccaaacag
    23701 agcccacccg aacgctcccc ctccctccgg gtagaaggcc aacaccgtgg accccctcca
    23761 ccccaccgac ccctcacaca tcggcagata cccgctgacc ggacgcctgg gcaccggagg
    23821 catgggccag gtctacctcg cccgcacccc atcccgccgc cagatcgtca tcaaggtcat
    23881 ccgccccgag ttcgcctccg aagcaggctt
//
