LOCUS       NZ_JARBUT010000004     25466 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Nocardiopsis sp. N85 Scaffold4, whole genome shotgun sequence.
ACCESSION   NZ_JARBUT010000004
VERSION     NZ_JARBUT010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nocardiopsis sp. N85
  ORGANISM  Nocardiopsis sp. N85
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 353137)
  AUTHORS   Liu,S.
  TITLE     Nocardiopsis sp. N85
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 353137)
  AUTHORS   Liu,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2023) Microbial Chemistry, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences, Tiantanxili No.
            1, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 1.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 182.0x
            Sequencing Technology :: combinatorial probe-anchor synthesis
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028882275.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 06:01:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,729
            CDSs (total)                      :: 5,663
            Genes (coding)                    :: 5,611
            CDSs (with protein)               :: 5,611
            Genes (RNA)                       :: 66
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 9 of 53
            Pseudo Genes (incomplete)         :: 46 of 53
            Pseudo Genes (internal stop)      :: 0 of 53
            Pseudo Genes (multiple problems)  :: 3 of 53
            CRISPR Arrays                     :: 13
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:47:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 236751
            Orig. end                         :: 262217
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JARBUT010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25466
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25466
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25466
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15466](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15466)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    3..16
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.77"
                     /tool="antismash"
     misc_feature    complement(6..20)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.85"
                     /tool="antismash"
     misc_feature    7..20
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    complement(8..21)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.52"
                     /tool="antismash"
     misc_feature    complement(247..256)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.52"
                     /tool="antismash"
     misc_feature    414..427
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.66"
                     /tool="antismash"
     misc_feature    complement(705..719)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            956..4096
                     /locus_tag="PWG71_RS08450"
                     /old_locus_tag="PWG71_08445"
     CDS             956..4096
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019607544.1"
                     /locus_tag="PWG71_RS08450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08445"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_274808997.1"
                     /transl_table=11
                     /translation="MRLRLLGSIRLGEGDHEITLGTGKERTLLVCLALAAPAPLPLETL
                     AERLWDDHPPTGYRATLHTYITRLRRTIIRAGGDRRTLLHTPEGYLLRLPAQDTDWGLF
                     TRLCSRARALSSTSERRTVRACLEKALELWAGDPIPEVTGQWAERTRLALRQAHQDALA
                     AWAHLAAQDHDHADIVGVLGAFLPLYPSDEVLHTHHIRALHTLGRTADALAVYHRLKDH
                     LAEHLGVDPSREARRLFAALLASTTEPTEPPLARSEPHVGMPASPVRDNLPQDPAHFHG
                     RTPEALLLTTRLTDPNTGTAATWVISGMPGIGKTVLALHAAHRVKNAFPHTRLYLDLRG
                     HHDRLEPLSIDDALIDLLRLARFPADRIPRTRAERIAVWREHTRTLRALIVLDDASDTD
                     QVLPLLPAGDRCATLITTRRRLPDLDGAEHLPLRPPSTAECATIFSIALGRDIAQDEAD
                     TVQEIIDRCERLPLVVRLAATTARLNPTWSLTDVLHSIPTPDVPATAGFRLGAVDLSSL
                     FATTLAALHPDHRYAFLQLGLHPTRTVSEPIAAALIDHHGATGALAALVDAHLVDEPRP
                     GRFAMHALVSAYSHHTALDQLSSTDIDAARHRMYQAYLDTARRADHTVYPHRPGRDDHE
                     NALPVQPWDETRALDWLRDETPALTVILSGARTHGHQGIADALTHTLSGHIDARGPWHH
                     APALHNRLTRPGAEGADPRSRARAHFDRARALLRLRRTEEALGENTVAHRLWSGLEDHL
                     GRAWAVAQEGMILYVADSYEASRSRFDEALELFEACVHRPGIVFSLRGRGLCHFNSSAF
                     HEAVSDFTDATTVLELAPDLQLLTETHINLAGAYHHLGYHHQAWALCERALGIARRRGD
                     EHKVALTLGNMSEIALHRGDPEQAIRCLEQALVIFQGFGDRWALATALSNLGVAENTAG
                     RPERARTYFRRSLALGDALSPSAEVTSLIGIAELETGDPHASQRSLRRALEIAQRHGLR
                     KERAQALYALGELLNRQGGAGDGLALLQQAADLFGELRAPETQILEALIEALKRPVE"
     misc_feature    968..970
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4379..4392)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.5"
                     /tool="antismash"
     misc_feature    4779..4792
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.67"
                     /tool="antismash"
     misc_feature    complement(4779..4793)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.42"
                     /tool="antismash"
     misc_feature    4816..4829
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.42"
                     /tool="antismash"
     misc_feature    complement(4817..4830)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.61"
                     /tool="antismash"
     gene            4857..6773
                     /locus_tag="PWG71_RS08455"
                     /old_locus_tag="PWG71_08450"
     CDS             4857..6773
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019607545.1"
                     /locus_tag="PWG71_RS08455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08450"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_274808998.1"
                     /transl_table=11
                     /translation="MVEGAHARGRPAVVVLTGPAGVGKTALATHLLHTHEHWGRDGAFF
                     VDLRGLSTPPTDPHEALGSLLHTVGIDRANLPADTATRAAWWRSATASTTITVLADNAL
                     TAAQVRPLLPAGPQTTLVVTSRSPLAGLRLHGARTIEVPPLNDTEGARLLTALAPAPSP
                     GSDTAVLRRISALCSGLPVALTTLALGHGTHHRARTWNQVEHHLTTARLAHLDATGRHL
                     DMDTTVSAAFDLSYTALPAETARLYRRLGWHPGPDITTDTAAPLTGRSAPECAQGLDTL
                     ARHHLLVRNGERYTFHDLIRLHAAHRADQDETPTEQNAALARLTASFAAQAGAADALIR
                     PYAGTVPTGAEVGFTDTAHALGWLETEHANLTAIAIIATDLNRTHDALHLLHGLWCLFL
                     HHSRTTPWMNAVTPAIAAAHHRGDDHTRAVLLNNRALLHSHLGDTPAAMADLDTAQTLW
                     TLLDDQVRLAQTLQRKGSVAFRAHLYDQAIDHLTHAVTVDETTGVTHNRAISHFMLGRA
                     HHALNAHRRAVDHLTLALDLLEDDRYNRARIRTVLGGALTDLGEYDRAEQTLQEALAGM
                     GEHGSASGQGKAWEALGDLARHQGEQARAQDAYRKAHELLPPTDPAHQRVSDHLHPPRP
                     QRE"
     gene            complement(7362..8528)
                     /locus_tag="PWG71_RS08460"
                     /old_locus_tag="PWG71_08455"
     CDS             complement(7362..8528)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019607547.1"
                     /locus_tag="PWG71_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08455"
                     /product="hypothetical protein"
                     /protein_id="WP_274808999.1"
                     /transl_table=11
                     /translation="MLAVVCTMADAQRLVDPVATLASDPRVQVVASIAPGQVFDTGLQE
                     WLHQAGVVIIPWPQATTTRFDLAVVASASRALESVHAPVALFAHGVGFNKLTPPVGTGG
                     SGQGALPRAVYGLSRESLLRDGRLLAARIALAHTEEAKRLAASCPEAVRAARVVGDGAA
                     DRLLSWLGRRDRCRAELGLAEGDRWVVAASTWGPSSLIGARRAVLERLVAEAAAAGWRA
                     GLLVHPNVWAAHGTWQVRQWLRPLMLRGLEVVPVQADWTGVLAAADAVVGDHGSSTVYA
                     TLTGRPLAVATAGHGDVVRGSPMECLLSALPEVTEDGSVLARLRRLRSLQEQAAVAAVA
                     ARVTSHPGEFASRTRAVLYDLLGLAEPDAPAVTRPVGSLGWALRRWSA"
     gene            complement(8919..10004)
                     /locus_tag="PWG71_RS08465"
                     /old_locus_tag="PWG71_08460"
     CDS             complement(8919..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019610915.1"
                     /locus_tag="PWG71_RS08465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08460"
                     /product="hypothetical protein"
                     /protein_id="WP_274809000.1"
                     /transl_table=11
                     /translation="MRFAHWFPLVPRPRPPADSLNARVERLTAAGRTARSGSDGEALAA
                     AAQVYNGAALLASDIGLPDLARTWCWEHAHAYLAHLPLNAAMAQRALEPVINLARLRIR
                     AGDGAEAFAILTALREGVRMAKATVIDSHELSLDRIVTSDEDRVELHRWLWTVCLGDGM
                     RALATEGRWQEAAEQARQHGGIGSRLFDGRQVAVIAALTGGDPRAALAMAEDSEVRERW
                     ERAVQALLVLWCRRESAEITTTDTETALGRIRDVDSGRVVFTTRLGIVATELLGGPQED
                     SSELASRLVSTIVHTQDGYAARDLLNAWKQELAQENVDTLGRVLEASGIDAMTLPEPFL
                     HVLGTALKEANRRLQHGLIPI"
     misc_feature    complement(9066..9068)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12031)
                     /gene="fxlM"
                     /locus_tag="PWG71_RS08470"
                     /old_locus_tag="PWG71_08465"
     CDS             complement(10001..12031)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019610916.1"
                     /locus_tag="PWG71_RS08470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08465"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_274809001.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.8e-29, bitscore:
                     96.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2e-50, bitscore: 165.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDERPQVLIQWTDWAAAEHWAVHELGPALEGAREEGIVPTWWF
                     VRKRPHWRLRYTGGRAARQFFDTELQRLRRERAVNRWVHGVYESETGVFGGASGMALAH
                     AVFCEDSHHLLAYLTRRDTAADAELGRRELALLLGSAFLRGARLDWFEQSDVWAKVAAL
                     RALPEPLYAEEELLSSARILLTLNPQHLPASGLLHHTGNWAQVFTAAGAALADLTAQGR
                     LSRGLRAVCAHHLIFAFNRWGLSYRDQHILSTTAREAAMTDTSHNAAPETADALREGLI
                     RQLRENGVLTAPAVEEAFRSVPRHTFVPNATLEEAYTNAPVHIKHDGNGASISCGSQPG
                     VVATMLEQAALEPGMRVLELGAGTGYNAALLGHLAGPTGSVTTIDVDQDLVEGARARLK
                     ENGAANVTVVLGDGALGHPDGAPFDRVIATVGCHDVPRAWVDQLAPGGRLIAPVRIAGD
                     VSRSIVFEARGDHWASVDSQLCTFMPLRGGGVGDDPRRILALDTDGTVLLQTNQDQSIT
                     PEQVERVLAEPSTTTWTGVDFGKGQPLDPMWLWLATRLDNRLSRMPVQPQAVASGLVSP
                     GLPWGDMAGVPEGERGLAYLTLRPVEGRQGRHEVGIIGHAPAGQELAEQMAEHIRAWEP
                     HRAKELSLALHYNPVSDQSTPVRRVLARAQSTLMVSWGDPV"
     gene            complement(12021..13268)
                     /locus_tag="PWG71_RS08475"
                     /old_locus_tag="PWG71_08470"
     CDS             complement(12021..13268)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573277.1"
                     /locus_tag="PWG71_RS08475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08470"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_274809002.1"
                     /sec_met_domain="LANC_like (E-value: 4.2e-43, bitscore:
                     141.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTITEATRIAGLVADRLATPEQGRALAGSRWWPQSLAHGAAGV
                     ALLHIERARTGHGPWERVQRWLECAVAEGVDSSPNAHLYYGAPAVAFVLHRAAAVHPGY
                     GGELARLDRAVGLIVASRLERAHARMDAGGLALLAEFDTVRGLTGLGALLLARDPQGPL
                     LRGLLAYLVRLTEPVTVQGRALPGWWSPVGPDGKKNAAFPGGHANTGMAHGIAGPLAIL
                     AAALRRKIAVKGHTEAITRILDWLDTWQRTSPSGAWWPYWVTHDQIDGARTLVGPQRPS
                     WCYGAAGVAHAQMLAADALGDHRRYATARSTLARVFTDTPLSSTALDFSLCHGLAGLAV
                     LARTTALGDAPGLWAVLRGGDSAAVADRLLTEAGIGLLEGAAGIATALHTLHTPSPDMG
                     WTAFFLLDHQEHHRDG"
     gene            complement(13265..15466)
                     /locus_tag="PWG71_RS08480"
                     /old_locus_tag="PWG71_08475"
     CDS             complement(13265..15466)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="PWG71_RS08480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08475"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_274809003.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.8e-171,
                     bitscore: 563.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.4e-19,
                     bitscore: 64.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASDKKQHVRWRVVGRPLVRASLFSGLPTDGVPDLGGTDPRPFLE
                     WLRRVREHPGLTEAVRHASPDLAAGVGALLDQDPAAVRVRRARKVTAAVLRYALRADSR
                     ATPFGLFAGVTAAAFSEHSRVVWGGAHRKVASPGGAWTAEVVGALEVLPGVCEHLLVVV
                     NNTAVQERGHLVVLQYTRPDPGAPGSDTEQVEIRIGSAVRLILETARQPVPWSTLRAKL
                     AAEYPDEPAVSADAMLARMVQVQALLTSLAPPSTETDLLGCLVSTLTGSNSWAPPEVRP
                     LVSHLQEAHTAVAEHNRGGGSSTLEEADEAVARVSRVQPLGVDVRVDADLALPVAVARA
                     AEQAAYMLTVLSPHPEGLPAWRTYRERFADRYGDALVPVHEVVHPRAGLGFPSAYAATA
                     GTEGSAETLTGRDRWLLEQAQIAALERRREITADTLLDQLAARRLAPLPGHTELNLRVE
                     SPSRAALDSGRFHIAVLGSSRSAATMAGRFAALAGVRDDLREAVSHTASAGAVPVQLSF
                     PPLRARSAPLVRSERLLDRAVSVGEYPGPGPRQLDVDDLAVGCDDGGLFLFSGALDRRV
                     EPVVPHALNLRYAPPLARFLAELPRAERAVVVGFDWGAASTLPFLPRIRSGRVILAHAR
                     WRIRAAELPSRTASWQQWRRGWAAWAELRGLPGVVDLGKGDQRLRLDLAEPAHLFLLRA
                     QVAKEGGTVLTEAPDPRSSGWCEGRSAEVLVQLCRQEVA"
     aSDomain        complement(14705..14989)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PWG71_RS08480_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-20"
                     /identifier="RREFam001.1"
                     /label="PWG71_RS08480"
                     /locus_tag="PWG71_RS08480"
                     /protein_end="254"
                     /protein_start="159"
                     /score="64.9"
                     /tool="antismash"
                     /translation="LVVVNNTAVQERGHLVVLQYTRPDPGAPGSDTEQVEIRIGSAVRL
                     ILETARQPVPWSTLRAKLAAEYPDEPAVSADAMLARMVQVQALLTSLAPP"
     gene            complement(15527..15682)
                     /locus_tag="PWG71_RS08485"
                     /old_locus_tag="PWG71_08480"
     CDS             complement(15527..15682)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="PWG71_RS08485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08480"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_274809004.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.6e-12, bitscore:
                     40.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLTETLNAEPSEPLTLDLRLIESASSTQPFPTSDDGCGSSCPSA
                     CTSTAN"
     gene            complement(15749..15907)
                     /locus_tag="PWG71_RS08490"
                     /old_locus_tag="PWG71_08485"
     CDS             complement(15749..15907)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019610919.1"
                     /locus_tag="PWG71_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08485"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_274809005.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7e-15, bitscore:
                     49.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNTECNPGPESPFTLDIRLLESSDSLAQLINLTDDGCGASCPTT
                     CVTSTSA"
     gene            complement(16019..16876)
                     /locus_tag="PWG71_RS08495"
                     /old_locus_tag="PWG71_08490"
     CDS             complement(16019..16876)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019610920.1"
                     /locus_tag="PWG71_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08490"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_274809006.1"
                     /transl_table=11
                     /translation="MTLEPDRAGQPRSELAEALRSLRRASGLTGARLAVRSGMSQAKVS
                     KIENGRVLPSALDVERILNALDVQLGEEEAARLLELARVANTDYQGFRTALQRGLGETQ
                     RDLAAIEASASAIRFFLPCMITGLLQTPDYARQTLSHMLVNRGASWETALARRLERQTV
                     LYDEGKRFVFVLTEAALRWPLCRPEAMAVQMDRIASLSELPSVDIRVVPADPPVPSGPL
                     NGFTVYDDRLVTVEVFTGKLALRDPKDISYSMEIFAFFHEHALEGENTRSFLRGLAQEY
                     RNRA"
     gene            complement(16877..17401)
                     /locus_tag="PWG71_RS08500"
                     /old_locus_tag="PWG71_08495"
     CDS             complement(16877..17401)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573282.1"
                     /locus_tag="PWG71_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08495"
                     /product="DUF6879 family protein"
                     /protein_id="WP_274809007.1"
                     /transl_table=11
                     /translation="MRLEGNAWREFFDSFQHEAFRLETLPSYTVPEEEEELRRFLAGET
                     RPAEELHTDGYLLRVRGHVESGRRIRRVHTLTSPVGDHLRFQFAWGYAFSVQAGEEVNI
                     LDFATTPDPGLPRQDFWLFDDTRVVLMHYAADGTQTGRELLEGADPAPYVTYKNLALEH
                     AVPFTEYYKAD"
     gene            complement(17385..17579)
                     /locus_tag="PWG71_RS08505"
                     /old_locus_tag="PWG71_08500"
     CDS             complement(17385..17579)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573283.1"
                     /locus_tag="PWG71_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08500"
                     /product="hypothetical protein"
                     /protein_id="WP_274809008.1"
                     /transl_table=11
                     /translation="MKFEKLSGDCNRDDCPGIYSTDKGTVVVQGALLTDTTGLTPSPGE
                     AAVEIPVHLIEEAARALGR"
     gene            complement(17748..18314)
                     /locus_tag="PWG71_RS08510"
                     /old_locus_tag="PWG71_08505"
     CDS             complement(17748..18314)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF045158.1"
                     /locus_tag="PWG71_RS08510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08505"
                     /product="DUF6879 family protein"
                     /protein_id="WP_274809009.1"
                     /transl_table=11
                     /translation="MPVSTPHELAEDEADTRSCRDLQVRGARCHRLLRRGHVVPTTPAR
                     TAWHQGRTDLAGELLLQERGRHAAEHAEFVSRGLSLTTLWIPDHLLTGYGHYTLATLNH
                     AHQAGQRILVGDPDQVRHMEVEEPLPEVTVYEAAVVYLHDHTLLGRRNGAVRIADPILA
                     AHLCEQLGELCRDAATFEALLGEVA"
     misc_feature    complement(17766..17768)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17928..17930)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18613..19476)
                     /locus_tag="PWG71_RS28670"
     CDS             complement(18613..19476)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="PWG71_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_342455949.1"
                     /transl_table=11
                     /translation="MSPRRSRSLRSSFPKVVHADSNFSGIGRTLQRISTFSYGFHQLAA
                     DARKGIEAEHLALDDGHPGGKRRPQKTPAAVPPAPGTAPTEHARGENVADPTESGIPTS
                     TSRTRPREDGPRFPGERANAFPWAGEVPPTSKVGLPAGEAAAVTTRSRRAQAVARRSFP
                     GVPGSVAHVRNWVEQTCAQWRVPIPEVLTLVASELASNAIAHTHSGRPGGQFATRLLLY
                     PDRMRLEVRDAGPLSGRTPLRRTPALTAEHGRGLVLVDALATDWGRLPAGTGTFVELPR
                     VPGRSA"
     misc_feature    complement(19378..19392)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.5"
                     /tool="antismash"
     misc_feature    complement(19387..19389)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19400..20209
                     /locus_tag="PWG71_RS08520"
                     /old_locus_tag="PWG71_08515"
     CDS             19400..20209
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="PWG71_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08515"
                     /product="Scr1 family TA system antitoxin-like
                     transcriptional regulator"
                     /protein_id="WP_274809011.1"
                     /transl_table=11
                     /translation="MPEKLLSAWTTFGKELRRLRDRRGLTLDQVAEATGYGASTISKYE
                     NAYRAPKRDFLNEAEALFGTNGDLLRRWTEAKRAEEDPDWHRKIVTAEEQASGIQIWNP
                     ALVPGMFQTPDYARQIFRDGRPLDTPEEIDRLVDLRVSRLDALRGMNDPRLVAILAEAV
                     VRARVGSPAVMKEQLGHLLDLDASGVVRILILPADTPYYGGAAGPFRLLSFKERETLVE
                     VEHASGGELLGGDTVTRLLAVYGELQTWALPPVASHDVISRAMGGLE"
     misc_feature    complement(19516..19530)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.84"
                     /tool="antismash"
     misc_feature    19583..19585
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20206..20394
                     /locus_tag="PWG71_RS08525"
                     /old_locus_tag="PWG71_08520"
     CDS             20206..20394
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.4"
                     /locus_tag="PWG71_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08520"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_342455950.1"
                     /transl_table=11
                     /translation="MIDLTSGWHKSSYSGAQGECVEVNEAAAPEAVLVRDTQNRDQGCL
                     SFPGGEWSAFLGATFSR"
     misc_feature    complement(20445..20461)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.82"
                     /tool="antismash"
     misc_feature    complement(20855..20872)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(20941..20957)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    20944..20960
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            21251..22081
                     /locus_tag="PWG71_RS08530"
                     /old_locus_tag="PWG71_08525"
     CDS             21251..22081
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_08525"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_274809012.1"
                     /transl_table=11
                     /translation="MNLSLLSEIESGFVAMAPAHLSLHGAHVHPLLEERTYSLYELRGV
                     LVAQATPNQLRDAVWRHTIRRARLSQDWMVGALGLAMPMLRSAVRQASRGLDKDSAESL
                     EAEVVTAAIRQIRVVTVEHSGLGYFLLCRVRRAAMGERKRAVATVARQVWGRAQEVDFE
                     AVPDAARSCESVLEAAVRAGTLSAGEAELIARTRLEGVSLVALSTETGAAYKTLAKRRQ
                     RAEARLATALRSVRTHALGGGQGGATSPVSPTPVCPSGRLFRREASNSGWPLAS"
     misc_feature    21292..21302
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            22265..22636
                     /locus_tag="PWG71_RS08535"
                     /old_locus_tag="PWG71_08530"
     CDS             22265..22636
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017613973.1"
                     /locus_tag="PWG71_RS08535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PWG71_08530"
                     /product="hypothetical protein"
                     /protein_id="WP_274809013.1"
                     /transl_table=11
                     /translation="MRSPAQKVWWGLALVGAVGLLVTGDASWAWAESREGAEQEASALL
                     QIVDRVQLILIVLGTALGTLFLTIAGVRWMVAGGEPGSIDSAKRALTGTAIGYGIAVLA
                     GTLMQILDWVLAAQAGSGQ"
     gene            22633..24501
                     /locus_tag="PWG71_RS08540"
                     /old_locus_tag="PWG71_08535"
     CDS             22633..24501
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PWG71_RS08540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PWG71_08535"
                     /product="hypothetical protein"
                     /protein_id="WP_274809014.1"
                     /transl_table=11
                     /translation="MTPPLPGGRSPADLEISDDPLPPPSDDPPPEGPEPEAGPEADPEI
                     TDDPLPPPEDPQGGEPPVVEPEPVELEVDDNVFDCDLIDAGCHVSNWFADFAVSGLNPA
                     LGWLASKAFYTPVPTEGMQGLHAGILGVSNTLFVLLVVAGGLIAMGHQSVQSRYSAADI
                     LPRIVWGFVAANVSLWISTEMITVSNQVSAAIGAQSIDPREAAENFRDRLDALVAEALI
                     FTVLLVVVVVILFVVWMITEAVRICMAIVLVIGAPLLLIFHALPHTNRVAEMWWRSMAG
                     LCAIPVGQSIVFMSLAKLFFEGQLTFADINHTSSATGDEVGDADWLMQLLLLLVLIYTQ
                     IRIGSWVMRLVWQPNPGTSPIASLLKNIAWMLAFRSVSGLRMPRALPSLGLHWPRRSPA
                     PPGRPLPRHTPAPPSGLQPLQPQAWWYRARHDPAGALGAGRPALPGPGGPAGPWPAGPG
                     APPGGGGPGTPGHPGRPRALPGPRALPPPGSQRGLPGVPPRRALEEGRMPGSPQTGQQV
                     LFPRPPAPAVRPQPASPTGAPRRRWRQLVLPTPPPVRVPGRRAPERLGWVGPRPRAAEG
                     LRHLPSMPALSWDKRPQVKGQIPLFSSPRRVWKQYGLFPRPDRDGA"
     misc_feature    complement(25323..25337)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 cgcataatta attgcaaaaa tttccagagg tgattggatc tatcgcaatt cgattatttg
       61 agtggcgggt gccctagggt gtgtggcgcg gttctcatta tgcctgcgag gggtaacaac
      121 tcgttgatcc gacacgggac gtcgtggcgg ctaaaggtct ttatcgcccc cgcgaggggt
      181 agcaacaagg tgccccgcac cgagccccgc aagctacgct tgtcctcatc gcccctgcga
      241 gggatcgcaa aaatcaaata gaagaatggg atcaccatcg agaacctcat gatcaccgcg
      301 aaggttaacc caatcagggt ttggtcatat gatcccaggt ttgatgaatc caactctcgg
      361 tgttacgggc atgtcatgat cgagtagcgg catgaagcac gcttagcgct gagtaggatt
      421 attatcttgg ctctcccggc cgctttcggt cattcgttta gcgagttcaa gttgatttcg
      481 gcctctgttt ttcttgttgc aggatgcgga cgcttctctg atgagatgag tccgcatgcc
      541 ctcgtcgtgt tgctccagtg cagggtgtgt actttgcgcg cttgtgaccc atcttgatgt
      601 ggcggtcggg gtggtgtgat catcccagta agcagcgttt tccatggttc cgtgccaagt
      661 cttgtcaagg gtgctgcatg gaagataatg gcctcgttct catgttctcc gaaggagaaa
      721 atggcctagg ttcaagggtg catggtgtga agttcctgga gtgatcctgt tggtgttcgc
      781 gggaaaggtg tttcgtgcgg ggtttggcaa atccaagtga atgtgacgtg tgttgtgaat
      841 ttgcacgtgc atcatcatgt gatggtgcgc gttatgaaat atatttttcg gatatgcgtt
      901 tattgtcatc cttcttgcgc acaaccctct tggagcctgc cgatgaggga ctaccatgcg
      961 actgcgctta ctgggatcca tccgcttggg cgaaggcgac cacgagatca cgctcggcac
     1021 cggcaaggaa cgaacgctcc tggtatgcct ggccttggcc gccccagccc cgctgccact
     1081 ggagaccctc gccgaacgcc tctgggacga ccatcccccg accgggtacc gcgccaccct
     1141 gcacacctac atcacccggt tgcgccgcac gatcatccgc gccggaggcg atcgccgcac
     1201 cctgctccac acacctgagg ggtacctgct tcggctcccg gctcaggaca ccgactgggg
     1261 gctcttcacc cgactgtgct cacgcgcccg agccctgtcc tccacctccg aacgccgcac
     1321 agtccgcgca tgcctggaaa aggcgttgga gctgtgggcg ggcgacccca tcccggaagt
     1381 caccggacag tgggccgaac gcacccgcct ggcactgcgc caagctcacc aggacgccct
     1441 ggccgcctgg gctcacctcg ccgcccagga ccacgaccac gccgacatcg tgggagtcct
     1501 gggagcgttc ctccccctct acccctccga tgaggtgctg cacacccacc acatacgcgc
     1561 cctgcacact ctgggacgca cggccgacgc tctagccgtc taccaccggc tcaaagacca
     1621 tctcgccgaa cacctgggcg tggacccctc gagggaagcc cggcgcctgt tcgctgcctt
     1681 gctcgcctcc accacagaac ccaccgaacc cccactcgcc cgcagcgagc cacacgtcgg
     1741 tatgccggcg tcaccggtgc gcgacaacct gcctcaggac ccggcccact tccacggccg
     1801 cacacctgaa gcactcctgc tcaccacacg cctcaccgat ccgaacaccg gcaccgcggc
     1861 gacgtgggtg atcagcggca tgccaggcat cggcaagacc gtgctcgcac tgcacgccgc
     1921 ccaccgtgtc aagaacgcct tcccccacac tcgcctgtac ctggatctgc gcggacacca
     1981 cgaccggctg gaaccgctga gtatcgacga cgcgctcatc gacctcctgc gcctggcccg
     2041 ctttcccgcc gaccgcatcc cccgcacccg cgccgaacgc attgctgtct ggcgcgagca
     2101 cacccgcacc ctgcgcgccc tcatcgtcct ggacgatgcc tctgacaccg accaggtcct
     2161 cccgctcctg cccgccggcg accgatgcgc aacgctcatc accacacgca ggcgactgcc
     2221 cgacctggac ggcgccgaac acctccccct ccggcccccc tccaccgccg agtgcgccac
     2281 gatcttctcc atcgctctgg gccgagacat cgcacaagac gaagccgaca ccgtgcagga
     2341 gatcatcgac cggtgcgaac ggctaccgct cgtggtgaga ctggcggcca ccacggcacg
     2401 cctgaacccc acttggtccc tgaccgacgt cctgcacagc atccccaccc ccgacgtacc
     2461 cgccactgcg ggattccgcc tcggcgcagt ggacttgagt tccctgttcg ccaccaccct
     2521 ggccgccctg caccccgacc accgatacgc cttcctccaa ctggggttgc accccacccg
     2581 cactgtgagc gaacccatcg cggccgccct catcgaccac cacggcgcca ccggcgcact
     2641 cgccgccctc gtcgatgccc acctcgtgga cgaaccccgc cccgggcggt tcgccatgca
     2701 cgccttggtc agcgcctact cccaccacac cgccctcgac cagctgtcct caaccgacat
     2761 cgacgccgcc cggcaccgca tgtaccaggc ctacctggac accgcccgcc gcgccgacca
     2821 caccgtgtac ccgcaccgcc ccggacgcga cgaccacgag aacgccctac cggtgcaacc
     2881 atgggacgag acccgagcac tggactggct gcgcgatgaa acaccggccc tgacagtcat
     2941 tctgagtggt gcccgcaccc acgggcacca gggcatcgcc gacgccctga cccacacgct
     3001 gtccgggcac atcgacgccc gcggaccctg gcaccacgca ccagcgctgc acaaccgcct
     3061 cacccgaccg ggtgccgaag gagcggaccc tcgctcccgg gcccgcgcgc atttcgaccg
     3121 cgcccgtgcg ctgctacgtc tgcgccggac cgaagaggca ttgggggaga acacggtcgc
     3181 ccaccgtttg tggtccgggc tcgaggatca cctgggccgc gcctgggctg tggcgcaaga
     3241 aggcatgatc ctgtacgtgg ccgactccta tgaagccagc cgcagccgtt tcgatgaggc
     3301 tttggaactc ttcgaggcct gcgtccaccg gcccggaatc gtcttctcgc tgcggggccg
     3361 cggactgtgc cacttcaact ccagcgcttt ccacgaggcg gtctccgact tcaccgacgc
     3421 caccacggtc ctggagttgg ccccggatct ccaactcctc accgagaccc atatcaacct
     3481 ggccggtgcc taccaccacc tggggtatca ccaccaggcc tgggcactgt gcgagagggc
     3541 gctgggaatc gcccgacggc gtggtgacga gcacaaagtc gcgctcacac tgggcaacat
     3601 gagtgagatc gctttgcatc ggggagatcc tgagcaagcg atccgctgct tggaacaggc
     3661 gctcgtgatc ttccaggggt tcggagaccg atgggccttg gccacagcgc tgtccaacct
     3721 gggagtcgcg gagaacaccg ccggtcggcc cgaacgggcg cgcacctatt tccgacgcag
     3781 cctcgctctg ggggatgcac tcagcccttc cgccgaggtc acgtccctga tcggtatcgc
     3841 tgaactggag accggcgacc cgcacgcctc ccaacgctcg ctcagacgcg cccttgagat
     3901 cgcacagcgc catggcctgc gtaaagagcg agcccaggcg ctctatgcct tgggcgaact
     3961 cctgaacagg cagggcggtg ccggggacgg tctcgctctt ctccagcagg cggcggatct
     4021 cttcggcgag cttcgcgcac ccgagacaca gatcctggaa gcactcatcg aggcgctgaa
     4081 acgacctgtc gaataagtga tgttttttcg gtcggcctgt ctgtctgtac gatgtcctgt
     4141 ggaccctgaa gtcaaggtct aaatgtcctt tttgtccgca gtggcgggac gccccgtagc
     4201 accgaggcgt cccgcctttc atcacaccga gggcagccct ctccctggtt tgcgctgagt
     4261 ggaggactgt cctcttcgga ggtgccatga agtacctgat tgtactccac gcaaaggcat
     4321 tttcggtcct cccgcaacgc acttggtttg ttgcatggat cgttttgcct gtcctggtgg
     4381 agcgtttgtt ctaacccttt cgtgactcca gagggctcag cccgtcgctg cacgcggcgg
     4441 gcattttttg tgttcaggca ggtcttggtc tcattgtcgg tactttgcac gtgcacaagc
     4501 ctgtgcatat cgagccaact gttcgtatgg cgggaatcac tacttgtgct gacgccagag
     4561 tccgctcaga ctggcccttg catgtccgaa accttcacat catccggacc agtaaggacc
     4621 ctgtgtgcag cgaacccacg acaccacctc ttgacgtccc atcattcgat tccaagtccc
     4681 ctcgggtaga aaactcgata caaggggata taaatggagt atcaatccaa ataggctcca
     4741 tgagtggagg aatctgcctt gcctctgcaa aattgacaaa gtttcaaaaa agtcaaatac
     4801 cactacctcc agtcgatttc atcgaaaaaa cgcaaaccgc ccgtaagtgc cgcgaggtgg
     4861 tcgaaggcgc tcacgcgcgc gggcgccccg ccgtggtcgt gctcaccggg cccgcagggg
     4921 tcggcaaaac cgccctggcc acacacctgc tccacaccca cgaacactgg gggcgcgacg
     4981 gcgccttctt cgtggacctg cgcggcttgt ccacaccccc caccgacccc cacgaagccc
     5041 tcggctccct gctgcacacc gtcggcatcg accgcgcgaa cctgcccgcc gacaccgcca
     5101 cccgggccgc ctggtggaga tcggccaccg cctccaccac catcacggtc ctggccgaca
     5161 acgccctcac cgccgcccag gtccgccccc tgctcccggc tggcccccaa accaccctgg
     5221 tggtcaccag ccgctcaccc ctagccggac tgcgcctgca cggcgcccgc accatcgaag
     5281 tgcccccctt gaacgacacc gaaggggccc ggctcctgac agcgctcgca cccgccccat
     5341 cccctggaag cgacaccgcc gtattgcgca ggatcagtgc cctgtgctcc gggctgcccg
     5401 tggccttgac caccctggcc ctgggacacg gcacccacca ccgggcccgc acctggaacc
     5461 aggtcgaaca ccacctcacc accgcacgcc tggcccacct ggacgccacc ggccgacacc
     5521 tggacatgga caccaccgtg agtgcagcct tcgacctgtc ctacaccgcc ctgcccgccg
     5581 agaccgcccg cctgtaccgc cgcctgggat ggcaccccgg acccgacatc accaccgata
     5641 cggccgcgcc ccttaccggc cgatccgcac ccgaatgcgc ccagggactg gacaccctgg
     5701 cccgccacca cctgctcgtg cgcaacgggg aacggtacac cttccacgac ctcatccgcc
     5761 tgcacgccgc ccaccgcgcc gaccaggacg agacaccgac cgaacagaac gcggcactcg
     5821 cacgcctgac cgcctccttc gccgcccaag ccggggcggc cgatgctctc atccgcccct
     5881 acgccggcac cgtgcccacc ggtgctgagg tgggcttcac cgacaccgcg cacgccctgg
     5941 ggtggctgga gaccgagcac gccaacctca ccgcgatcgc gatcatcgcc accgacctga
     6001 accgcaccca cgacgccctg cacctgctgc acggactgtg gtgcctgttc ctccaccaca
     6061 gccgcaccac cccctggatg aacgccgtca cccccgcgat cgctgccgcc caccaccgcg
     6121 gcgacgacca cacccgggcg gtgctattga acaaccgtgc cctcctccac agtcacctcg
     6181 gtgacacccc tgcggccatg gccgacctcg acaccgcaca gaccctgtgg accctcctcg
     6241 acgaccaggt gcgcctggcc cagaccctcc agcgcaaagg cagtgtggcc tttcgcgccc
     6301 acctgtacga ccaagccatc gaccacctca cccacgcggt cacggtcgac gagaccaccg
     6361 gtgtcaccca caaccgcgcc atcagccact tcatgctcgg ccgcgcccac cacgccctga
     6421 acgcccaccg ccgtgccgta gaccacctca ccctcgccct ggacctgctg gaggacgacc
     6481 ggtacaaccg ggcccgtatc cgcaccgtcc tgggcggtgc actcacagac ctaggggagt
     6541 acgaccgagc cgagcagacc ctgcaggagg cattggcggg gatgggcgag cacgggtcgg
     6601 cctccggcca gggcaaagcc tgggaggccc tgggcgattt ggcccgccat cagggggagc
     6661 aggcccgggc ccaagacgcc taccgcaaag cccacgaact cctgcccccc actgacccgg
     6721 cccaccagcg cgtgagcgac cacctgcacc ctccccgccc ccagagagag tgactcaccc
     6781 gccccgggcg tgcaccgtga accacgacac ggcgccctca cccctcccca tcccgtgcac
     6841 ggggaggggg agcgccacca cacgtgtggg tgaatcttcg cccccgctcc cagccctcat
     6901 gcaccagcgg gcgtagaccg ccaccagggt tgctcccgcc tcctgccacg ccccggcggt
     6961 ccggccccca ccctccccgg ggacatgcac cgtcttcccg gtgcgtgacc atccccgcac
     7021 cccaccgtcg ggggagaaca cacccgccag cgcacacccc ggataggcct ccaacacctg
     7081 cgtggcccag gtgtccgccg ccgaaccctc cccggagacg gcggacatca ggatgtcggc
     7141 gcaccccgcc cacccggccc ctccgggaaa agcgggatcg accacgagaa cctcatcgac
     7201 cacccacgcc cggccacccg cacccgccaa ccggtcggcc cggtccgacc ccggacacgg
     7261 agcggccccg gccaccgcat tcacatcggg aaccaccctc tgcgtttccc cacgaatctg
     7321 accgcgatgc cccggcccct gccccgggcc cttgtgagct ctcacgccga ccacctccgc
     7381 agagcccacc ccagcgaccc caccgggcgc gtcacggcgg gggcatccgg ctcggccaaa
     7441 cccagcaggt cgtacagcac cgccctcgtc cttgacgcga actcaccggg gtgggaggtc
     7501 acacgggccg cgaccgcggc caccgccgcc tgctcctgga gcgaccgcaa ccgacgcaac
     7561 cgcgccaaca ccgacccgtc ctcggttacc tccggcaacg ccgagagcag acattccatg
     7621 ggcgaacctc gcaccacatc accgtgcccc gcggtcgcta ccgccaacgg acgccccgtc
     7681 aacgtcgcgt acaccgtgct cgacccgtga tcacctacca ccgcatccgc cgccgccagc
     7741 acccctgtcc agtccgcctg gaccggcacc acctccaatc cgcgcagcat cagcggacgc
     7801 aaccactgcc gcacctgcca cgtcccgtgc gccgcccaca cgttcgggtg caccaacaac
     7861 cccgctcgcc agcccgcagc agcggcctcg gccaccaacc gctccagaac cgcacgccgc
     7921 gcaccgatca gcgaggacgg tccccacgtc gaggccgcta ccacccaccg atcaccctcg
     7981 gccagcccta gctcggcacg gcaccggtca cgacggccca accaggacaa caatcggtcg
     8041 gcggcgccat cgcccaccac ccgggccgct ctcaccgctt caggacagga cgcggccagc
     8101 cgcttcgcct cctcggtgtg cgccaaggcg atccgggccg ccaacaaccg cccgtctcgg
     8161 agcagcgact cccggctcaa gccgtacacc gcccgcggaa gcgcaccctg gccggatcca
     8221 ccggtgccca ccggcggggt gagcttgttg aacccgaccc cgtgcgcgaa cagcgccacc
     8281 ggggcgtgca cgctctccag ggcacggctc gcgctggcca ccacggcaag atcgaaccgt
     8341 gtggtggtgg cctgcggcca ggggatgatc accaccccgg cctggtgcag ccactcctgc
     8401 agaccggtgt cgaacacctg ccccggagcg atggaagcca cgacctgtac ccgtgggtcc
     8461 gaggccaggg tcgctaccgg gtccaccagc cgctgcgcgt cggccatggt gcacaccact
     8521 gccagcacct tccggtccac tttccaggtg gtccaccgct ccgcctctat cccgatcggc
     8581 gcacgaaccc agctccgcat ctcacatctc ccttgttcac cgccccgcct ggtctgcagg
     8641 gctctctcca aagatgcgaa gaaggtcgaa cacagggctg gatgcaggcc tggacggcca
     8701 ctgaacaagc actggattcg cagccggatt aatacgctgg gttatcaaga ggtgggcggt
     8761 acctgtgggc tggttctcac tgggccgtgt ggtgagctgt ggcctgtgca gagtaggtga
     8821 tcacgggggc cgttcgagca tgggcggcag atactcgtcc accgggcggt ttccggagtg
     8881 ggtgatctcc gcccattccc cggaagcggc cctctctgtc aaattgggat gagaccgtgc
     8941 tggagccttc gattcgcttc tttcagcgcc gttccgagca catgaaggaa cggctcgggc
     9001 aacgtcattg cgtcgatccc cgacgcctcg agcacccgtc ccagcgtgtc cacgttctct
     9061 tgggctaact cctgcttcca ggcgttgagt aggtctcggg ccgcgtaccc gtcctgtgtg
     9121 tggacgatgg tgctgaccag acgcgaagcg agctcggagg agtcctcttg gggacctccg
     9181 aggagctccg ttgcgacgat cccgagccgt gtcgtgaaca cgacccggcc gctgtcgacg
     9241 tcacggatac ggcccaaggc cgtctcggtg tcggtggtcg tgatctcggc ggattctctg
     9301 cgacaccaca gaaccaagag cgcctggacg gccctctccc accgttcccg aacctcactg
     9361 tcctcggcca tggccagcgc agctctcgga tcgcccccgg tgagcgcggc gatgacggcg
     9421 acctggcggc cgtcgaaaag gcggctgccg atcccgccgt gctgccgggc ttgctcggcg
     9481 gcttcctgcc atctgccttc agtagccagg gcgcgcatcc cgtctcccaa gcacaccgtc
     9541 cacagccagc ggtgcagctc cacccggtcc tcgtcggagg tgacgattcg gtccagggag
     9601 agctcatggc tgtcgatcac ggtggccttt gccatgcgca ccccttcgcg cagggcggtg
     9661 agtatcgcga aggcctctgc gccgtcgccc gcgcggatcc ggagtcgggc caggttgatc
     9721 accggctcca gagcacgttg ggccatggcg gcgttcaacg gcaggtgcgc caggtacgcg
     9781 tgtgcgtgct cccaacacca cgtgcgggcc aggtcgggca gtccgatgtc cgaggcgagc
     9841 agggccgcgc cgttgtagac ctgcgcggcg gcggccagag cctccccgtc cgagccggac
     9901 cgtgcggttc gtcccgctgc ggtgaggcgt tccacgcgag cgttcaggct gtccgccggc
     9961 gggcgcggac gggggacgag cgggaaccag tgcgcgaacc tcatacggga tctccccagg
    10021 agaccatcag ggtggactgg gctcgcgcca gcacccgccg caccggggtg gactggtcgg
    10081 atacggggtt gtagtgcagg gcgagggaga gctcctttgc gcggtggggt tcccaggccc
    10141 ggatgtgctc ggccatctgc tcggccagct cttgcccggc gggggcgtgc ccgatgatgc
    10201 cgacttcatg gcggccctgt cggccttcca ccggacgcaa cgtcaggtat gccagtccgc
    10261 gttcgccctc ggggacgccg gccatgtccc cccagggcag cccgggagag accaggccgc
    10321 tggccacggc ctgcggctgc accggcattc gggagaggcg gttgtccagg cgggtggcca
    10381 gccacagcca catcgggtcc aggggctggc ccttgccgaa gtccaccccc gtccaggtgg
    10441 tggtggaggg ctcggcgagc acgcgctcca cctgttcggg tgtgatgctc tggtcctggt
    10501 tggtctggag caggaccgtc ccgtcggtgt ccagggcgag gatgcgacgg gggtcgtcgc
    10561 cgacgcctcc tccgcgcagg ggcatgaacg tgcacagctg gctgtccacg gatgcccagt
    10621 ggtcgccgcg ggcttcgaag acgatggagc gggagacgtc tccggcgatg cgcaccgggg
    10681 cgatgagcct gccgccgggg gcgagttggt ccacccaggc gcggggcacg tcgtggcagc
    10741 ccaccgtggc gatcacccgg tcgaaggggg ctccgtcggg gtggccgagc gcgccgtcac
    10801 ccagaaccac ggtcacgttg gcggcgccgt tctccttcag ccgggcacgc gcgccttcga
    10861 ccaggtcctg gtcgacgtcg atggttgtga ccgacccggt cggcccggcc aagtggccga
    10921 ggagggcggc gttgtacccg gtgcccgcac ccagttccag cacacgcatg ccgggttcca
    10981 gggcggcctg ttccagcatc gtcgcgacga ctccgggctg tgatccgcag ctgatggagg
    11041 cgccgttgcc gtcgtgcttg atgtgtacgg gggcgttggt gtaggcctct tccagggtgg
    11101 cgttggggac gaaggtgtgg cgcggtaccg agcggaacgc ttcctccacc gccggggcgg
    11161 tgaggacacc gttctcccgc agctgccgga tgagtccttc gcgcaaggcg tcagcggttt
    11221 ccggtgcggc gttgtgggag gtgtcggtca tggcggcctc tctggcggtg gtggacagga
    11281 tgtgctggtc ccggtaggac aggccccacc ggttgaaggc gaagatcaag tggtgggcgc
    11341 acaccgcgcg cagaccccgg ctcagccggc cctgggcggt gagatcggcc agggcggctc
    11401 cggccgcggt gaagacctgc gcccagttgc cggtgtggtg cagcaacccc gacgccggaa
    11461 gatgctgcgg gttgagggtc aggaggatgc gcgctgagga gagcagctcc tcttccgcgt
    11521 acaagggctc gggaagggca cgtagggcgg cgaccttggc ccagacgtcg gactgctcga
    11581 accagtccaa ccgggcaccg cgcaggaagg cactgcccag caggagggcg agctcgcgac
    11641 ggcccagctc ggcatcggct gctgtatctc ggcgcgtcag gtaggcgagg agatggtggc
    11701 tgtcctcaca gaacacggcg tgggccagcg ccatccccga cgctccgccg aaaaccccag
    11761 tctcggactc gtagacgccg tgcacccagc ggttgacggc tcgctcgcgt cggagccgct
    11821 gcagttcggt gtcgaagaac tgtcgggctg ctcggcctcc ggtgtagcgc agccgccagt
    11881 gtggcctctt acggacgaac caccacgttg gcacgatccc ttcttcgcgg gctccttcga
    11941 gtgccgggcc tagctcgtga acggcccagt gctcggcggc ggcccagtcg gtccactgga
    12001 tgaggacctg tggccgctcg tcatccgtca cggtggtgct cctggtggtc gaggaggaag
    12061 aaggcggtcc aacccatgtc gggagaaggg gtgtgcaacg tgtgcagagc ggtggcgata
    12121 ccggctgccc cctccagcag gccgattccg gcttcggtga gcagacggtc cgccaccgcg
    12181 gcggagtcac cgccccggag cacggcccac agtccggggg catcgcccag ggcggtggtg
    12241 cgggcgagca ccgccagccc agcgagaccg tggcacagag agaagtccag cgccgtcgag
    12301 gagagagggg tgtcggtgaa gacgcgggcg agcgtgctcc gcgccgtggc gtagcgccgg
    12361 tggtcgccca gggcgtcagc cgcgagcatc tgcgcatggg ccacacccgc agcgccgtag
    12421 caccacgagg gacgttgcgg gccgaccaaa gtgcgggccc cgtcgatctg atcgtgggtg
    12481 acccagtacg gccaccacgc cccggatgga gacgtccgtt gccaggtgtc gagccagtcc
    12541 aggatgcgcg tgatcgcttc ggtgtgcccc ttgaccgcga ttttgcgccg cagggccgcc
    12601 gcgaggatgg ccaggggacc ggcgatgccg tgggccatac cggtattggc gtgtcctccg
    12661 gggaaagcag cattcttctt cccatcgggt ccgaccggac tccaccaacc gggaagagca
    12721 cggccttgca cggtgaccgg ctcggtcaac cgcaccaggt aggccagcag gccccggagg
    12781 agcgggccct gcgggtcacg ggccaggagc agggcaccca gtccggtcag gcctcgaacg
    12841 gtgtcgaact ccgcgagcag cgcaagccct ccggcgtcca tccgcgcatg cgcccgctca
    12901 agccgggaag ccacgatcag tcccacggcc cggtccagcc gggcaagctc acccccatac
    12961 ccggggtgga ccgctgcggc ccggtgcaga acgaacgcca ctgcgggcgc gccgtagtac
    13021 aggtgcgcgt tgggagagga gtccaccccc tcggcgaccg cgcactccag ccaccgctgg
    13081 acacgttccc acgggccgtg cccggtgcgc gcccgttcga tgtgcaacaa cgccactccg
    13141 gccgcgccgt gcgccagcga ctggggccac caccggcttc cggccagcgc acgcccctgc
    13201 tccggtgtgg ccaggcggtc ggccaccagt cccgctatcc tcgtcgcttc ggtgatcgtg
    13261 gtattcacgc gacctcctgt cggcagagct gaacgagcac ctcggccgac cgcccctcgc
    13321 accatccgga cgagcgcggg tccggcgcct cggtgagaac cgtgccacct tccttggcca
    13381 cctgggcacg cagcaggaac aggtgcgctg gttcggcaag gtccaggcgc agacgctggt
    13441 cgcccttgcc caggtccacc accccgggca gaccacggag ctcagcccag gccgcccacc
    13501 ctcgccgcca ctgttgccac gacgcggtcc gtgagggaag ttcggcggct ctgatacgcc
    13561 accgggcatg ggccaggatt acccggcccg agcggatacg gggcaggaac ggcagtgtgg
    13621 aggccgcgcc ccagtcgaat ccgacgacca ccgcgcgttc ggcgcggggg agttcggcca
    13681 ggaaacgggc cagaggcggg gcgtatcgca ggttcagcgc gtgcggcacg acaggctcga
    13741 ccctgcggtc caacgcgcct gagaacagga agagaccgcc gtcatcgcat ccgaccgcga
    13801 gatcgtccac atccagctgc ctcggtcctg gaccggggta ttcgcccacg ctgacggcgc
    13861 gatcgagaag acgctccgaa cgcaccagag gggcgctgcg ggctcgcagc ggtgggaacg
    13921 acaactgcac cggcaccgcc ccggcggagg cggtgtgcga tacggcttcg cgcaggtcgt
    13981 cccggacacc ggccagggcg gcgaaccggc ccgccatggt ggcagcgctg cgggaggagc
    14041 ccagcaccgc gatgtggaac cggccgctgt ccagcgcggc ccgtgagggc gactccacgc
    14101 gcaggttcag ttccgtgtgc ccaggaagcg gcgcgaggcg ccgggccgcc agctggtcca
    14161 ggagcgtgtc tgcggtgatc tcccgccgcc gttcgagggc ggcgatctgg gcctgctcca
    14221 gcagccaacg gtcgcggccg gtgagggtct cggcgctgcc ttcggtgcca gcggtggcgg
    14281 cgtatgcgga aggaaagccc aaccccgccc gggggtgcac gacctcgtgg acgggtacga
    14341 gcgcgtcgcc gtaccggtcg gcgaatcgtt cccggtaggt gcgccacgcg ggcagccctt
    14401 ccgggtgagg ggacaggacg gtcagcatgt acgcggcctg ctctgccgca cgtgccaccg
    14461 ccacgggcaa ggccaggtcg gcgtccaccc gcacgtccac tcccagcggc tggacccggg
    14521 acacccgcgc gaccgcctcg tcggcctcct ccagagtgct ggagccgcca ccgcggttgt
    14581 gctccgccac cgccgtgtga gcctcctgga gatgcgacac cagcggccgg acttcaggcg
    14641 gagcccagct gttgctcccg gtgagagtag agacgaggca tccgaggagg tcggtttcgg
    14701 tggacggcgg ggcgagagag gtgagcaacg cctgcacctg gaccattcgg gcgagcatgg
    14761 cgtcagcgct cacggcaggt tcatcggggt actcagcagc cagtttggcc cggagcgtcg
    14821 accacggtac gggctggcgt gctgtttcca ggatcaggcg tacagcgctg ccgatacgga
    14881 tctcgacctg ctctgtatcc gacccgggcg cacccgggtc ggggcgcgtg tactggagaa
    14941 ccacgaggtg tccgcgctct tggactgcgg tgttgttgac gacgaccagc aggtgctcac
    15001 acaccccggg aaggacctcc agcgcaccga cgacctcggc cgtccatgcc ccgcccggag
    15061 aggccacctt ccggtgggcg ccaccccaca ccacccgtga gtgctcggag aaggctgcgg
    15121 cggtcacgcc ggcgaacagc ccgaagggag tggcgcggct gtcggcccgc agcgcgtagc
    15181 gcaggacggc agcggtcacc ttccgtgctc ggcgtacccg caccgcggcc ggatcctggt
    15241 cgagcagagc ccccacaccg gctgccaggt cgggcgaggc gtgccggacc gcctcggtca
    15301 gacccgggtg ctcccgcaca cggcgcagcc actccaggaa cggacgcggg tcagtgccgc
    15361 ccaggtccgg aacgccgtcc gtcggcaggc cgctgaacag gctcgcccgc accagcggtc
    15421 ggccgaccac acgccaacgt acgtgctgct tcttgtcgga agccatctcc cctcctccca
    15481 gaagtgctgg tcggcaccgg atccgggccg gtgccgaccg tgcgggtcaa ttcgcggtac
    15541 tggtgcacgc gctcgggcag ctggatccgc agccgtcgtc actggtgggg aacggctgtg
    15601 tggagctggc cgattcgatg aggcgaaggt ccagggtcag cggctcggat ggttcggcgt
    15661 tgagggtctc ggtcaagcgc atgaactctc ccgtgagtgc tggcggtgat gaacggatca
    15721 gagactcggc agagccggca ggcgctgttc aggccgacgt gctggtgacg caggtggtgg
    15781 ggcagctggc accgcagccg tcgtcggtga ggttgatcag ctgggccagg gagtcgctgc
    15841 tctcgagcag cctgatgtcg agggtgaagg gggattccgg gccggggttg cactccgtgt
    15901 tctgcacagg gctttccttt ctcatggggg cctgtgagca cagctcagat taaggacccg
    15961 caagagacag gtgaaggagt ttcccgccaa ggaataaatt cgccttcagc ggtgccggtt
    16021 atgcccggtt tcggtattcc tgggcaaggc cgcgaaggaa tgacctggtg ttttcgcctt
    16081 cgagtgcgtg ctcgtggaag aaggcgaata tctccatgct gtaggagatg tccttcgggt
    16141 cgcgcagggc gagcttgccc gtgaacactt cgacggtcac cagccggtcg tcgtagacgg
    16201 tgaacccgtt gaggggaccg ctgggcacag gaggatcggc gggcacgacg cggatgtcca
    16261 cgctgggcag ctcactcagg gaggcgatcc ggtccatctg caccgccatc gcctccgggc
    16321 ggcacagcgg ccagcgcagg gcggcctcgg tcaggacgaa cacgaagcgt ttgccctcgt
    16381 cgtagagcac cgtctggcgc tccaggcgcc gtgcgagcgc cgtctcccag ctcgcaccgc
    16441 ggttcaccag catgtgcgac agggtctggc gcgcgtagtc cggggtctgt agaagcccgg
    16501 tgatcatgca cggcaggaag aagcggatgg cggacgccga ggcctcgatc gcggccaggt
    16561 cccgctgggt ctccccgagc ccgcgctgga gcgcggtgcg aaaaccctgg tagtcggtgt
    16621 tggccacacg ggccagctcc agcaggcgcg cggcctcttc ctcgccgagc tggacgtcga
    16681 gcgcattgag gatgcgctcg acgtccagcg cggagggcag cacgcggccg ttctcgatct
    16741 tgctgacctt ggcctggctc atcccgctgc ggacggcgag ccgcgcgccg gtcagccccg
    16801 aggcgcggcg gaggctgcga agggcctccg ccagctcgct gcgcggctgt ccggcacggt
    16861 cgggctcaag cgtcaatcag tcggccttgt agtactcggt gaaggggacg gcgtgctcca
    16921 gggccaggtt cttgtaggtg acataggggg cggggtcggc cccctccaag agctcccggc
    16981 cggtctgggt tccgtcggca gcgtagtgca tgagcaccac gcgggtgtcg tcgaagagcc
    17041 agaagtcctg gcggggcagg ccggggtcgg gggtggtggc gaagtcgagg atgttgacct
    17101 cttcgccggc ctgcacgctg aaggcgtagc cccacgcgaa ctggaagcgc aggtggtctc
    17161 cgacggggct tgtcagggtg tgcacgcgcc ggatccggcg cccggactcg acgtggccgc
    17221 gtacccggag caggtagccg tcggtgtgca gctcctcggc tgggcgggtc tccccggcca
    17281 ggaaccggcg cagttcctct tcctcctcgg gcaccgtgta gctgggcagg gtctccaggc
    17341 ggaacgcctc gtgctggaag gagtcgaaga actcccgcca ggcgttacct tccaagcgca
    17401 cgggcggcct cctcgatcag gtgcacgggg atctcgaccg cggcctcccc cggggagggg
    17461 gtgaggccgg tggtgtcggt caggagcgcg ccttgtacga cgacggtccc cttgtcggtg
    17521 gagtagattc ccgggcagtc atcccggttg cagtcgccgg agagcttctc gaacttcatg
    17581 gtgtggccct ttctgaaagg gtcgaaacgg aatttacagt agagaagtgg gcgggctcgg
    17641 tcaatctctg gccggatatt cctgcctggg aataaaaccg ggccgtgtgg gtgccctgtg
    17701 ctgtttgtgt ggagcggtca ttacatggaa gtcagaggca gaactgctta tgccacctcc
    17761 ccgagtaagg cttcgaaggt tgcggcatcc cggcacagtt cccccaactg ttcgcacagg
    17821 tgggcggcga ggatggggtc ggcgatccta accgctccgt tccggcgccc gaggagggtg
    17881 tggtcgtgca ggtacaccac ggccgcctcg tagacggtca cctccggtaa cggctcttcg
    17941 acttccatgt gccgcacctg gtctgggtct cccacaagga tgcgctgacc ggcctggtgc
    18001 gcatggttca gagtcgccag ggtgtagtgc ccgtagccgg tgaggaggtg gtcgggtatc
    18061 cacagggtcg tcagagacag gccgcgggac acgaactccg cgtgttcggc ggcgtgcctt
    18121 ccgcgctcct ggaggagcag ttccccggcc aggtcggttc ggccctggtg ccaggcggtc
    18181 ctggcagggg tggtgggcac cacgtggccg cggcgcagga gccggtggca ccgggctccc
    18241 cgtacctgga ggtcccggca gctccgggtg tcggcctcgt cctctgccag ctcgtggggt
    18301 gttgatacgg gcaacgggtc tccttgttcc tgctcgctga agggcatgga cgttgtggcc
    18361 gcggttgcgg ggcggcccgc tggcctgtcg ccgcacacgg tcatgagggc tggtcgagga
    18421 aggcgcggac ctctccgagg tcgtggagga tcgcggtgtc tccgtcaagc ggagtgagtg
    18481 cgtacaccgc tcccagcaac cgtttctggc gggtgaggac atagccctgc tgagcggcgc
    18541 gccaccggac atcgttgaaa tcagccagag cacggatgac cacagggcga gagcgggtcc
    18601 gtcgcgggaa cttcatgcac tcctccccgg tactcggggg agttcaacga aggtgccggt
    18661 tcctgcgggc agccgtcccc agtcggtggc gagggcgtcc acgagcacca gtccccggcc
    18721 gtgctcggcg gtgagggcgg gggtgcggcg cagcggggtt cggccggaga gaggaccggc
    18781 atcgcgtacc tccagccgca tgcggtccgg gtagaggaga aggcgggtgg cgaactgccc
    18841 gcccggccgg ccgctgtggg tgtgggcgat ggcgttggag gccagctccg aggccaccag
    18901 cgtgagcacc tccgggatgg ggacccgcca ctgtgcgcag gtctgctcaa cccagttgcg
    18961 cacatgcgcc accgagcccg ggactccggg gaaggacctg cgcgcaaccg cctgtgccct
    19021 ccgggagcgg gtagtgaccg cagcggcctc accagccggc aggccgactt tcgacgtggg
    19081 cggcacttca ccagcccacg ggaaggcgtt cgcacgctcc ccgggaaacc ggggtccgtc
    19141 ttctcgtgga cgagtgcgcg aggtgctggt tggaatacct gattcggtag gatctgccac
    19201 gttctcacct ctggcgtgtt cggtgggagc cgttcccggg gctggtggca cagccgccgg
    19261 ggttttctgt ggtcgacgct ttccgccggg gtgcccatcg tccaaggcga gatgctccgc
    19321 ctcaatgcct ttacgtgcat cggccgctag ttggtggaac ccgtacgaga atgtagagat
    19381 tctctgtaaa gttctaccta tgcctgagaa gttgctgtca gcatggacca ccttcgggaa
    19441 ggagctccgc aggctgcgtg accggcgtgg gctcactctg gaccaggtgg ccgaggcgac
    19501 cggatacggt gcgtcaacta tcagtaaata cgagaacgcc tatcgagcac caaaaaggga
    19561 ctttctcaac gaggcggagg cattattcgg tacgaacggt gaccttctcc gtcgctggac
    19621 agaggcgaag cgggccgagg aggatcctga ctggcaccga aagatcgtca cggccgaaga
    19681 gcaggcgtcc gggatccaga tatggaaccc tgctcttgtc ccgggtatgt tccaaacgcc
    19741 cgactacgcg cgccagatct tccgcgacgg tcggcccctg gacacgccag aggaaatcga
    19801 ccggctcgtg gacctgaggg tcagccgcct cgacgcgctg agggggatga acgacccgcg
    19861 tctggtcgcg atcctcgccg aggcggtcgt ccgagcccgt gtcggttcac ccgcagtgat
    19921 gaaggaacag ctgggacatc tcctcgatct ggacgcctcc ggggtcgtga gaatcttgat
    19981 cctgccagcg gacaccccgt actacggcgg agctgccggc ccgttccggc tgttgtcctt
    20041 caaggagcgc gagacgcttg tcgaagtcga gcacgcctcc ggcggcgaac tgctcggcgg
    20101 agacaccgtg acgcggcttc tggccgtgta cggggagctg caaacgtggg cgctaccccc
    20161 tgtagcctca catgatgtga tttcgagagc catgggaggc ttggagtgat cgacctgacc
    20221 agcgggtggc acaagtccag ctacagcgga gcccagggcg agtgcgtcga ggtcaacgag
    20281 gctgcggctc ccgaagctgt cctcgtcagg gatacgcaga accgggacca gggctgcttg
    20341 tccttccccg gcggagagtg gagcgcgttc ctcggtgcga cgttctcccg gtaaccccaa
    20401 cagcagtgga ccgctctcgc cgagttaggg tctgttccgg gttttgccca ctgttcgggc
    20461 actcgctctc cgggtgagtg cccgaaccgg tagacccgta ccgtggcacg tggtgacctc
    20521 accgatggcg agtgggacct gatcaaaccg cacctgctcc tgggcgccgg cggacccatc
    20581 cccgacctgc gcagctactt caacgccatc atgtggcggt tccgtgccga cgcgcctggc
    20641 acgacgttcc cgaacgctgc ggctcttggt ccaccatcta cgaccggtcc cgcctatggg
    20701 cctccagtgg ccccttccgg gacctcactc ctcgcctacc caccggacgc cccagcgtcg
    20761 cgagaacggg aatcccggcc cttccggccg cagcagagcc acatccttcg gttgcttcca
    20821 gtcgtagtcc gaacaccgct cgcggaaaga gcaatatcgg cttcaaggaa aacgcggagc
    20881 gctctcaggt ggcgttttcg aagcttttca agcgcagact ttgggcgtct cggaagagcc
    20941 ttgctgaaat tttccaacga actctgaagt gagcactcgc ggtgactcat gagtctgctc
    21001 acgggtgggt gagcgtgccc gcgatcccag tgtcttgcca gttagaagcc ctgagtgttc
    21061 gctcatccgc atggcaggct ccgttggcaa atcggctctc cgccggagat actttacctt
    21121 ttcttggtgt gtgtgagtcg cttctgagtc atgtttgagc agggcctgag tcggttctga
    21181 tcaacccctg agtccgcggt gtctttcagt ggttcctgtc ggaccccgat ggcgcaacca
    21241 gggaggacac atgaaccttt cgctgctttc tgagatcgaa tccggtttcg ttgccatggc
    21301 acccgcgcac ctgagcctgc acggggcaca cgtgcacccg ctccttgagg agcgcaccta
    21361 ctcgctttat gagctgcgcg gcgtcctggt ggcccaggcg actccgaacc agctcaggga
    21421 cgcggtgtgg cggcacacca tccggagggc tcgcctgtcc caggactgga tggtgggggc
    21481 gctcggcctt gccatgccga tgttgcgatc ggcggtgcgt caagccagcc gaggtctgga
    21541 caaggacagc gcggagagtt tggaggccga ggtggttacc gccgcgatcc gccagatccg
    21601 cgtggtcacc gtggagcact ccgggctggg ctatttcctg ctgtgccggg tgcgccgggc
    21661 cgccatgggg gagcgtaagc gcgccgtggc caccgtcgcc cgccaggtgt ggggccgggc
    21721 tcaggaggtc gacttcgaag ccgtgcccga tgcggcccgc tcgtgcgagt cggtcctgga
    21781 ggcggctgtg cgtgccggga ccctgtcggc gggtgaggcg gagttgatcg ctcgtactcg
    21841 cttggagggg gtctcgctgg tggcgctgtc caccgagacc ggggcggcct acaaaacgct
    21901 ggccaagcgt cggcagaggg ccgaggcccg gttggccacc gcactgcgat cggtccgcac
    21961 tcacgctttg ggaggtgggc aggggggagc gacttcacct gtttcgccta cgcctgtgtg
    22021 cccctcgggg cggctttttc ggcgcgaggc gtcgaattcg ggctggccgt tggcttccta
    22081 accaagtgag agggctggta ggcccaccgg cccggaaggc ggtgggttca ccggtcgcca
    22141 ggcggcggcc ggaggagggc gcggccgggc cctggacgtg aggatcccgg cggagtcgat
    22201 gtcgcattcg cgtcttcgtc ccgcttcctg aaaaggcgtc accgcgaaga agggagggga
    22261 acgtatgcgt tcaccggcgc agaaggtctg gtgggggctg gccctggtcg gagccgtcgg
    22321 gttgctggtc acgggggatg cctcgtgggc gtgggcggag tcccgggagg gtgccgagca
    22381 ggaggcgtcg gcgctgcttc agatcgtgga ccgggtgcag ttgatcctca tcgtgctcgg
    22441 taccgccctg ggcacgctgt tcctgacgat cgccggggtg cggtggatgg tcgcgggcgg
    22501 ggaaccgggg tcgatcgact ccgccaaacg ggcgctgacc gggaccgcca tcggctacgg
    22561 catcgcggtc ctggccggca cgctcatgca gatcctggac tgggtgctcg ccgcacaggc
    22621 cgggagcggc cagtgacccc gcccttgccc ggtgggcggt cgcccgcgga tctggagatc
    22681 agcgatgacc cgctgccgcc tccgtccgac gacccgccgc cggaaggacc cgagcccgag
    22741 gccgggccgg aggcggatcc ggagatcacc gatgatccgc tgcccccacc ggaggaccct
    22801 caggggggcg agcctccggt ggtggagccg gagccggtgg agctggaggt cgatgacaac
    22861 gtcttcgact gcgacctgat cgacgccggg tgccacgtga gcaactggtt cgccgacttc
    22921 gccgtctcgg ggttgaaccc cgcgctgggg tggctggcgt ccaaggcgtt ctacaccccg
    22981 gtccccaccg agggcatgca agggctgcac gccgggatcc tgggcgtgtc caacaccctg
    23041 tttgtgctgt tggtggtggc gggcggtctg atcgcgatgg gccaccagag cgtgcagagc
    23101 cgctactcgg ccgccgacat cctgccccgg atcgtatggg ggttcgtcgc ggcgaacgtc
    23161 tcgctgtgga tctccaccga gatgatcacc gtctccaacc aggtctcggc cgcgatcggc
    23221 gcccagtcca tcgacccccg ggaggccgcc gagaatttcc gcgaccggct ggacgccctg
    23281 gtcgccgagg ccctgatctt caccgtgttg ctcgtggtgg tcgtggtgat cctgttcgtg
    23341 gtgtggatga tcaccgaggc ggtgcgcatc tgcatggcca tcgtcctggt catcggcgca
    23401 ccgctgctgc tgatcttcca cgccctgccg cacaccaacc gggtcgcgga gatgtggtgg
    23461 cggtccatgg cgggcctgtg cgccatcccc gtcgggcagt cgatcgtgtt catgtccctg
    23521 gccaagctgt tcttcgaggg gcagctgacc ttcgccgaca tcaaccacac ctcctccgcg
    23581 acaggggacg aggtgggcga tgccgactgg ctgatgcagt tgctcctgct gctggtgctg
    23641 atctacaccc agatcaggat cgggtcgtgg gtgatgcgcc tggtgtggca gcccaacccc
    23701 ggcacctcac ccatcgcctc gctgttgaag aacatcgcct ggatgctcgc cttccgcagc
    23761 gtcagcgggc tgcgcatgcc gcgcgccctg cccagcttgg ggctgcactg gccgaggcgt
    23821 tcaccggccc cgccgggcag gcctctgccg cgccacaccc cggccccgcc cagcggactg
    23881 caaccgctac aaccgcaggc ctggtggtac cgggcccgcc acgacccggc cggagcgctc
    23941 ggtgcaggcc gcccggcgct gcccggccca ggaggccctg cgggcccgtg gccagccggt
    24001 ccaggagcac ctcccggtgg gggcggcccc ggcacaccgg gacaccccgg tcggccacgg
    24061 gctcttcccg gcccgcgcgc gttgccccca cccgggtcgc agcgcggcct gcccggagtt
    24121 ccaccacgtc gtgccttgga ggagggacgt atgcccggat caccccagac gggacagcag
    24181 gtgctgttcc cgcgcccgcc cgcaccggcg gtgcggccgc aaccggcctc gcccaccggg
    24241 gctccgcggc ggcggtggcg gcagttggtg ctgcccacgc ccccgccggt gcgggtgccc
    24301 ggcaggcgtg cccccgagcg cctggggtgg gtcgggcctc gtccccgggc ggcggagggc
    24361 ttgcggcacc tgccgtcgat gcccgccctg tcctgggaca aacgccccca ggtgaaggga
    24421 cagatcccgc tgttctccag cccgcggcgg gtgtggaagc agtacgggct cttcccgcgc
    24481 ccggaccggg acggggcgtg accccgtcat gaagaacacg actgagaagg aggaggtgct
    24541 catggcatcg gatgaggcgt cgtcgtggcg ggggaggatc ccggccgaca tcgatcggcc
    24601 cgaaccgatc ctgttcggcc tgaccgcacg acagtgcctg atcattgccc ccgcgctggc
    24661 gggggcatgg gggatctacc tgctcttccg tgaccacgtt ccctggtggg cgatcatggc
    24721 ggccctcgtt ccgttcctgg gcgtgatcac cgccctcgcc ctgagcgagc gcgacggccg
    24781 gggcctggag caggtcgcgg ccagcgccct ggcgtggttg cgcgccccca agcacttggt
    24841 ctccgcccct actgggcagg ttccggtgct gccccggtgg gcgccccgga cccggcgcgc
    24901 ctcccggttg gagccgctgc ggctgcccgc ctcggccatc tccccggagg gggtgatcga
    24961 cctgggcgga cggtgcgcgg tgatgatcgc ctgcaccacc atccccttcc aactgacctc
    25021 cgggcgcgag caggaccaag cacttgcggc gttcgcgggc gttctggacg ccctcaccga
    25081 gtcggtgcag ttcctcgtcc aacgccgcag cgccgacctg acgggcttca ccgcgatggt
    25141 gcgcaacggc gccgcccacc taccgcatcc ggccctggcc gaagccgcgt tggcgcacgc
    25201 cgacttcctg gacgagctgg ccgcgacgca tgagctgtcc caccagcagg tggtggccgt
    25261 ggtcagcgcc actggttccg cccgccgggc cgggaccgct ctgcggcgca ccgcacagga
    25321 cgtggccgac cggctcgcca ccctcggcat ccgcacccag gtcttggagg ggcccgaggc
    25381 cgaacaggtt ctgcgccaag cgatggccgc cccggacagg agcctccccg ctctcgcccc
    25441 ggacaccgac accaccgacg gataca
//
