LOCUS       NZ_CP118233            26373 bp    DNA     circular CON 13-JUL-2024
DEFINITION  Micromonospora chalcea strain 1K05785M01 chromosome, complete
            genome.
ACCESSION   NZ_CP118233
VERSION     NZ_CP118233.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora chalcea
  ORGANISM  Micromonospora chalcea
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Study on the Growth Characteristics and Drug Resistance Related
            Proteins of Micromonospora chalcea MCCC 1K05785
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-FEB-2023) Tianjin University, Tianjin University,
            Weijinlu Nub92, Tianjin, Tianjin 300072, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2022
            Assembly Method                   :: CLC NGS Cell v. 5.29
            Assembly Name                     :: TJU-micro-1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028768405.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 23:01:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,224
            CDSs (total)                      :: 6,161
            Genes (coding)                    :: 6,110
            CDSs (with protein)               :: 6,110
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 16 of 51
            Pseudo Genes (incomplete)         :: 40 of 51
            Pseudo Genes (internal stop)      :: 2 of 51
            Pseudo Genes (multiple problems)  :: 7 of 51
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:37:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6605108
            Orig. end                         :: 6631481
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP118233.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26373
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="26"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26373
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26373
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16373](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16373)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(187..1314)
                     /db_xref="GeneID:91360476"
                     /locus_tag="PVK74_RS29990"
                     /old_locus_tag="PVK74_29990"
     CDS             complement(187..1314)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91360476"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="PVK74_RS29990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_29990"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_274477738.1"
                     /transl_table=11
                     /translation="MSEGDNFVRCVAVLADDAERAGKLEWSDVVRVVTARGLGDALPEI
                     VLALRDLGVEVAAPAGIAPDGGTSAGRDAATLPASMRIHAVLRAEDEVNLGRRIQLGLA
                     AAETAASLGIDPAPPAQALIDDGRQARDALILANIRLVISMVRRYTHRSGDLDFDDLVQ
                     EGVKGLHRAAEKFDPEKGFKFSTYASWWIRQSVERAIADTGTLVRLPVHVWEQVRKVEN
                     YARSFEARNGRPASLAEIAGGVQEDPARVQALLDWSSPVVHLDASVAAVDGEATLGDLV
                     LVATEPGPEEAVVTSDVAVGLRQRLTEVLDPRSLRIVEARFGFGDQDEATLESIGIEHG
                     ISRERVRQLESKIFEVLRKDRDVRALAEMVLGRAA"
     misc_feature    1955..1967
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.67"
                     /tool="antismash"
     gene            2168..3034
                     /db_xref="GeneID:91360477"
                     /locus_tag="PVK74_RS29995"
                     /old_locus_tag="PVK74_29995"
     CDS             2168..3034
                     /EC_number="3.1.21.-"
                     /codon_start=1
                     /db_xref="GeneID:91360477"
                     /inference="COORDINATES: protein motif:HMM:NF021064.4"
                     /locus_tag="PVK74_RS29995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_29995"
                     /product="Eco29kI family restriction endonuclease"
                     /protein_id="WP_274477739.1"
                     /transl_table=11
                     /translation="MTDKWAADFRLSITRALADQLETTLRPLKPTPLTAANLSAVLGRP
                     GVYALFFNERRVYVGKAAKSLQDRLTQHLRKLSGRTGLDSASVRFVCVYVDEDLDAAAP
                     EKLLIKKYREHDSIPWNTNGFGNKDPGRNRDTSVVKAAHFDATYPIDLDYQCRQEPGMQ
                     SVAAVLEAAKGQLPYLLRFDSGAAAKKTYRDTLMVVPAQPLAARDLAHQLVAALPAGWQ
                     LTALPGYLILYQERRRYDSALGWWRRESDGDVQYTPGPRQFAAGAVDVEAADVSGGDAT
                     SLFELDA"
     misc_feature    2702..2704
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3065..4084
                     /db_xref="GeneID:91360478"
                     /locus_tag="PVK74_RS30000"
                     /old_locus_tag="PVK74_30000"
     CDS             3065..4084
                     /codon_start=1
                     /db_xref="GeneID:91360478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455993.1"
                     /locus_tag="PVK74_RS30000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30000"
                     /product="HNH endonuclease"
                     /protein_id="WP_274477740.1"
                     /transl_table=11
                     /translation="MPTFVDYVEISLAAAREQWQAILTRTPVTAGRQVAFLPVETLTCL
                     AASLLVNHRKYGGSTAHRAEAPVPALGRLFQRPNSSVLAKMANLDGSRRNGAKYEIEVA
                     AHLLAVPGRLGAVYRVILAAARDVGIDSENLPDFLGITDDDTDLRLIGQDELEAAEVEE
                     AVQATSTAWLESRADLDEQTTERLLVAAARIGQHRFAREVLRNHGHRCVFCGLSVKVAG
                     DKAPRMLVASHIKPWRTSTPAERLDARNGLTACPTHDVAFDTGLMTVNGGLRIHLKPSL
                     AHAVRMDTATRAAFGRPPLADRLLLPAAAPPPRARYLTWHHLHIYGDTPSTPSDSPLR"
     gene            complement(4212..4628)
                     /db_xref="GeneID:91360479"
                     /locus_tag="PVK74_RS30005"
                     /old_locus_tag="PVK74_30005"
     CDS             complement(4212..4628)
                     /codon_start=1
                     /db_xref="GeneID:91360479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020519351.1"
                     /locus_tag="PVK74_RS30005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30005"
                     /product="very short patch repair endonuclease"
                     /protein_id="WP_274477741.1"
                     /transl_table=11
                     /translation="MRANKARDTGPERRVRSLLHKMGLRYRINARPMAGLRRTADVVFS
                     AARVAVFIDGCYWHGCPEHYRPARANDRFWSEKIAGNRARDAETNGLLTEAGWTVIRIW
                     EHENPTEAADRVATAVREAASNRRARPERSSLSS"
     gene            complement(5024..6328)
                     /db_xref="GeneID:91360480"
                     /locus_tag="PVK74_RS30010"
                     /old_locus_tag="PVK74_30010"
     CDS             complement(5024..6328)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91360480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787618.1"
                     /locus_tag="PVK74_RS30010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30010"
                     /product="DNA cytosine methyltransferase"
                     /protein_id="WP_274477742.1"
                     /transl_table=11
                     /translation="MSEPPGEQIRDRTSVELFAGGGGLAMAVHRAGFRPLLVNELVKYA
                     CDTLEANAAVDRGETERVPLPGERWPLARGDVSGVKFDYLWDRVDLLAGGPPCQPFSLG
                     GVARGDEDKRNMFPEMFRAIRKIQPKAVMCENVRGLLRPSFRPYFEYIERELQLPFQER
                     DHDSTWRDHDEVLKERLAEDPPDPKRRYDVVTTTVNAADYGVPQIRNRIIIVAFRSDLG
                     VDIERFKRSVRPRYSEAALIRSMLDGTYWRRHPQVPEHVRERVMSRLPTTPPEDDGRLP
                     WRTLRDAIQGLDGQPPLPPVPWDWLDRREHNLGGFTDHIGWPDARIYAGHTPNELDRPA
                     KTVKAGVHGVPGGESVMLTDDLWHEPAGEKPYPYRHRYMTVRETARVMTFPDNWLLAGP
                     RGEKMRQLGNAVPVVLGEFFAKAIAAALDEAESQR"
     gene            6479..6901
                     /db_xref="GeneID:91360481"
                     /locus_tag="PVK74_RS30015"
                     /old_locus_tag="PVK74_30015"
     CDS             6479..6901
                     /codon_start=1
                     /db_xref="GeneID:91360481"
                     /inference="COORDINATES: protein motif:HMM:NF025444.4"
                     /locus_tag="PVK74_RS30015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30015"
                     /product="DUF4259 domain-containing protein"
                     /protein_id="WP_274477743.1"
                     /transl_table=11
                     /translation="MATWQFGPFDNDDAVEWCDALEAAPLDQRVELVHDTLAVAVAGRA
                     LTAGEAARAVAAAATALQSLNGVPFSNSAYAPRFLSDKGAMAVDSSIRDLAVQALGEVL
                     ANGSAWRLRWADDIEEEEALAVVESLRSHLVSAVTP"
     gene            complement(6902..7822)
                     /db_xref="GeneID:91360482"
                     /locus_tag="PVK74_RS30020"
                     /old_locus_tag="PVK74_30020"
     CDS             complement(6902..7822)
                     /EC_number="3.1.21.-"
                     /codon_start=1
                     /db_xref="GeneID:91360482"
                     /inference="COORDINATES: protein motif:HMM:NF021064.4"
                     /locus_tag="PVK74_RS30020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30020"
                     /product="Eco29kI family restriction endonuclease"
                     /protein_id="WP_274477744.1"
                     /transl_table=11
                     /translation="MPSPSPRARDRRQSLVERLAAIADELQAIHPPRHTATRNALRGAL
                     AAEAKRLDQAVTRLDPILRPRGLFDPSAPSTTGRIVALTMIAQQRHPLAALRPFYGAGV
                     YALYYNGPFDAYSPISRTEQPIYVGKADPQDAEAKDAVSQGTRLHRRLNDHRKSIQKAT
                     STLRLEDFECRFLIVQTGYQSAAEEQLIQFFQPIWNNDTKICSGMSKHGDNAETRSNKR
                     SPWDTLHPGRQWADALAEDQKPESLIRKEIDVHFRRVPPHRTLESIVGGVIGDLAQLAP
                     TSFTTAAGKDIPVEADFDENMPNDV"
     gene            complement(7840..8520)
                     /db_xref="GeneID:91360483"
                     /locus_tag="PVK74_RS30025"
                     /old_locus_tag="PVK74_30025"
     CDS             complement(7840..8520)
                     /codon_start=1
                     /db_xref="GeneID:91360483"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="PVK74_RS30025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30025"
                     /product="hypothetical protein"
                     /protein_id="WP_274477745.1"
                     /sec_met_domain="PCMT (E-value: 1.2e-13, bitscore: 49.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPALCSSTNSSPTSGSPHRRVRAAFHRVPRHLFAADGISLDVAY
                     ANDVIITSRGPDGRATSSISEPWLQAAMLHAAHLQLGARVLEVGSGGYNAALIADIFGP
                     GGTVATVDIDAAVIDRARTTLDPCRLPAGDEQDGLRGHAPAVTPDLHDYRETPLRERCL
                     GDGPQNDNYVYKALRSRAASRFGRPYLVSTYHQETCCSKAEPCQALWSLVDEAWDTCAR
                     KSPG"
     misc_feature    complement(8047..8049)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8784..9869)
                     /db_xref="GeneID:91360484"
                     /locus_tag="PVK74_RS30030"
                     /old_locus_tag="PVK74_30030"
     CDS             complement(8784..9869)
                     /codon_start=1
                     /db_xref="GeneID:91360484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287254.1"
                     /locus_tag="PVK74_RS30030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30030"
                     /product="hypothetical protein"
                     /protein_id="WP_274477746.1"
                     /transl_table=11
                     /translation="MPLSFTPSIATRFPLVARRRPPAKPLDARVTRLAGLAETAHREHD
                     PEKASMVFNGAALVASDCADAELAELWCHHHARLYLSRAPLNGYTARFALEPVVNLARL
                     RIRVGDGETAHQLLTALYHAVANSEPIVIGELEIHPRQLPVKVEERQEITSWLRNILLS
                     DGTRALTAGGRWADAVKHVERYDGIGTTLHDGRQVAVVAHLIHGSTRTATAILNRTTIE
                     HPWEELVRDLLHAWSAATVGDRSLADHRELIDRASTMATGPGLSLFRTRLVLTALDLSP
                     DLCTAAATAVIDRMVAEVFQEQDANAARELLKGPGVGPEYHGPLRQMISASGLGLGRLP
                     DSARRTLSSALALAGTAIHST"
     gene            complement(10001..12082)
                     /db_xref="GeneID:91360485"
                     /gene="fxlM"
                     /locus_tag="PVK74_RS30035"
                     /old_locus_tag="PVK74_30035"
     CDS             complement(10001..12082)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91360485"
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020609514.1"
                     /locus_tag="PVK74_RS30035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30035"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_274477747.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-22, bitscore:
                     78.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 3e-41, bitscore: 140.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLDPEADTEAPPGVAPVSRWRQVNLSFASWRAAEEYAATRLAPA
                     LAVAEDDGVTAAFWFIRKTETWRLRLLPGGQLNRFYWLLADITADDRIRDVVEPVYRPE
                     AYAFGGDHAMTIAHTLFHADSRHILGHLAAGGDHRRELGVLLATRLMRAAGLEFSEQGD
                     VWHKVAARRHQPQAPTPSPGLIAAMQRLLTAADDAPRSPLSATPQWSRAHEQAGRDLGF
                     LDRHGTLTRDLRGVLTYHILFLFNRLGISAADARHLATAAVHVTFHTSTIPPGYHLAGS
                     TDSRVKAVKNSPADPADFSAAELREQLVTTLKQRGHLRSARVEQAFRTVPRERFLPGVD
                     LETVYTRRQIVTKRDPTGAALSSASSPSLVADMLEQLDPQPGDHILEIGAATGINAALL
                     AELTNPGGMVVTIELDQDLADGARAGLDRAGYDTVEVICGDGALGHPESAPYQRIIVTA
                     GAWDISAAWWDQLAERGRLVVPLRVHESGLTRCFAFDRADPTTLVSTTAPLVCGFVPLR
                     GAAEHTDQHVRLDTDAALKLDANDQPDRAALARALSHPRYERWTGIQVTDDDPIGHLDL
                     WLLVNASKPFGRLRAGDTARTSGLLTPAYRWAGAAIYDGGTIAYLAFQQSSDGHHELGA
                     IANGPDADKLAAELTDLLDQWDSAGRPNQPIVTAHRTGTRPVQTGDISRPDTTLTISF"
     gene            complement(12097..13359)
                     /db_xref="GeneID:91360486"
                     /locus_tag="PVK74_RS30040"
                     /old_locus_tag="PVK74_30040"
     CDS             complement(12097..13359)
                     /codon_start=1
                     /db_xref="GeneID:91360486"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287252.1"
                     /locus_tag="PVK74_RS30040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30040"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_338020353.1"
                     /sec_met_domain="LANC_like (E-value: 3.4e-40, bitscore:
                     136.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTPLATPLLRAAETMASCISDTLMEPPALPDGVDYGPRSTRWY
                     GQSLSKGAAGVAILHGVRAQTGHGEWEPVRAWLRHASAETLNNGTGAGLWFGAPAVTHA
                     LTTAMPHARPAALNALDTAVADLTEHRLTAADARLAASARPRLAEFDLVRGLTGLGAHL
                     LRRSPDGDLLRRVLAYLVRLTEPVDADDAVGLLAPGWWSADPPSNGESRERGGHANVGM
                     AHGITGPLALLSLAMRRDIRVPGQSEAIDRICSWLDTWQQTDAAGPRWPEKITVAELRA
                     GRPAITGPARPSWCYGTPGMARAVQLAGIALSDSDRQQAAEDALARCVADPVQLGRIID
                     PSLCHGWAGLAATLWYAAADARDTRLPASVPYLMRLLVQHATDPTPASSGLISGPAGIA
                     LALHTFATGTDIHWSTSLLIT"
     misc_feature    complement(12523..12525)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13356..16373)
                     /db_xref="GeneID:91360487"
                     /locus_tag="PVK74_RS30045"
                     /old_locus_tag="PVK74_30045"
     CDS             complement(13356..16373)
                     /codon_start=1
                     /db_xref="GeneID:91360487"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020609516.1"
                     /locus_tag="PVK74_RS30045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30045"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274477749.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.5e-180,
                     bitscore: 599.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.5e-14,
                     bitscore: 51.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-22, bitscore:
                     78.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRVVDAASIRIAARVWPNREAPWPHRHDPAGVESWLRATWRQVG
                     VSEAVWVASPALADRVEAALADARLDAGQAWRMALAVARYRARARGRATPFGLFSGVAP
                     LRLDAVAAVTPSERSAIRVRPDAEWLASLIALLEADPTVRNGLSVQANNLAQVSGLRIV
                     VHCRPHASVPADGISSVRRTEAVRLAMSLSAEPVRWAELVDKIAAGYLEFPRASVEALV
                     AGLVEQGVLISSLRPPSTCTDPIKHLLDQLDAAPDVESVRQTVKKLRTLHGHLGVTTGQ
                     AIDLGGLTARMRELAVVAQPLAVDLRLADQVVVPHQVAAEVVASVEVLRRLTPHPTGRP
                     QWRAYHSRFVDRYGMAALVPLAEVVDPVTGLGFPEHFGDADLAAPLSARDERLLALAQQ
                     AALDDVRELILDDATVGALAGPDHAGGSVSPHVDVTAEVRAVSLRALAEGRFVVAVTGM
                     GRSAVATSGRFLDVLPYAERELMRGQFARLPVAVEGAMAAQVSFPPRKLHAQNVLSSPQ
                     VLPWLVSMAEHRPTAEDMIALDDLGVAADAARLVVVSMSRRRVVEPTVAHAGAVHTMPL
                     LARFLVELPRALDARLKPFDWGAASCLPFRPALRYGRVLLSAARWRIDPARLPAADASD
                     GRWSVAWDGLRERLRLPRWVQVGRSDQRLRLDLDQAMDRSLLRAHLDANRDAGITIVEA
                     AGSEDFGWLSGRAHEIVVPVASTAAAAAAPASVAARASWPPCAPADPVLPGESGLLSGS
                     LAVDPSTVELVLRRGLPALFADWPEPPMWWFIRMRRPYSHLRLRLHTDDYGQAAIRVGR
                     WAVALRRQGLAGDLRLDTYRPETGRYGTGPAMSAAEELFGADSRAALAQLAAKDSQIAP
                     QALTAASMLDLAAAMLGSRESGCEWLVARPEHAGRAPIDRGVLRQAVALDPTLMPDEVQ
                     RAWQERAQAAGRYADALSAFSGPLTPATVLTSLTHLHFVRAHGPDEAAEQVTYRLARHI
                     ALATVRRRVPTPGAAR"
     misc_feature    complement(14127..14129)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15186..15188)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15468..15470)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(15660..15923)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PVK74_RS30045_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.00E-16"
                     /identifier="RREFam001.1"
                     /label="PVK74_RS30045"
                     /locus_tag="PVK74_RS30045"
                     /protein_end="238"
                     /protein_start="150"
                     /score="51.4"
                     /tool="antismash"
                     /translation="ANNLAQVSGLRIVVHCRPHASVPADGISSVRRTEAVRLAMSLSAE
                     PVRWAELVDKIAAGYLEFPRASVEALVAGLVEQGVLISSLRPP"
     gene            complement(16483..16617)
                     /db_xref="GeneID:91360488"
                     /locus_tag="PVK74_RS30050"
                     /old_locus_tag="PVK74_30050"
     CDS             complement(16483..16617)
                     /codon_start=1
                     /db_xref="GeneID:91360488"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016815038.1"
                     /locus_tag="PVK74_RS30050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30050"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_073827131.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.9e-11, bitscore:
                     41.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLLAVSGEPFQLDVEIVTEGPVAAALLGDTDDGCDTVRGGDC"
     gene            16992..18212
                     /db_xref="GeneID:91360489"
                     /locus_tag="PVK74_RS30055"
                     /old_locus_tag="PVK74_30055"
     CDS             16992..18212
                     /codon_start=1
                     /db_xref="GeneID:91360489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018810019.1"
                     /locus_tag="PVK74_RS30055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30055"
                     /product="hypothetical protein"
                     /protein_id="WP_274477750.1"
                     /transl_table=11
                     /translation="MISPNTVLSDARHRLPSPVRPGQRMSRSELADAVNTALDRIYPDR
                     DVTAQYVDSRWVGKLERGEHRWPSEARRTALRQVLGAVTDADLDLYSPRRSDGVEAEGP
                     TVEPQPGSWEEAIYLLREQWHLLVQNDKMFGPEYALMGVTRQLATIEGTLSGVPQALRP
                     AVIRLAAQYAESAAWLHQSLNDHAAGHRRTRQALAWADEIADPPMTAWATYRSSQQWLA
                     SGRAAEAVEQAEAALLHDPKLPRPMRAALRVQHAHALAAAGEHQSAMRLLDSAHRWAAD
                     RYPGKPEGEHASYCTSGYIEVHRGACLRLAQRPQAAIEVLDQALPAIPRRHRQDFASAL
                     LLKAMAHAAARQPDQAAAAAHHALPIARRAGSRWVLHQLAQLGAAVSGHQQLPEVHAFL
                     YDLQEMT"
     gene            18212..19096
                     /db_xref="GeneID:91360490"
                     /locus_tag="PVK74_RS30060"
                     /old_locus_tag="PVK74_30060"
     CDS             18212..19096
                     /codon_start=1
                     /db_xref="GeneID:91360490"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012601.4"
                     /locus_tag="PVK74_RS30060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30060"
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
                     RibD"
                     /protein_id="WP_274477751.1"
                     /transl_table=11
                     /translation="MASDVELAAMRQAITLSSIGLGTTSPNPPVGCVILDRYGVTIGEG
                     YHRCKGEAHAEVNALSAAGPAVQGGTAVVTLEPCNHIGVTPACRQELIDAGIARVVISV
                     LDPTSRGDGGAAVLTAHGIDVETNVLPDETLTVLGPWLAATRRRRPYLIWAYALDKQNS
                     QLVNEQLAVDLRSRTDLVLNDKTLEEGVPGGHAPEHFTLPHDLSADLRSWLSACYATGS
                     RTIVAVGADHSGALHENLDCVDEIVIAVKKAAPTGVIAAATADLTTAGFELADISPGRT
                     CVRVRLRRPNASP"
     gene            complement(19487..20731)
                     /db_xref="GeneID:91360491"
                     /locus_tag="PVK74_RS30065"
                     /old_locus_tag="PVK74_30065"
     CDS             complement(19487..20731)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91360491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014688066.1"
                     /locus_tag="PVK74_RS30065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30065"
                     /product="IS701 family transposase"
                     /protein_id="WP_274479311.1"
                     /transl_table=11
                     /translation="MLTVGQRFRRPEPRRRVCDFVRGLLAPLPRKNCWSIAEHAGDAGP
                     DGMQDLLTRVTWDDAEVRADVREFVGEHLGDGEAVLVIDETGDLKKGRHTVGVQRQYSG
                     TAGKIENCQLAVHLVYATEAAHAMLDTALYLPKSWCDDPERRAEAGVPEQVRFATKPQL
                     AARMIAAAVTAGLPCRWAAGDEAYGNDPRLAARLRQLRLGYVLAVACSHQVITGLGVYR
                     VDALAAELPDTAWQRISAGRGAKGHRYYDWAFIALPHAIDDQSGHHWLLIRRSRRTGEL
                     AFYRCWSPEVVALGTLVAIAGRRWKIEESFQAAKTGLGLDQHQHRRWTSWHRWNTLAIL
                     AHAFLAAATAEHRNHYQPVGLIPLTVNELRHLFHILIIEPTRRRCDPLLWSIRRRRHQA
                     KAMTSHYARQALIEP"
     misc_feature    complement(21098..21112)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(21133..21381)
                     /db_xref="GeneID:91360492"
                     /locus_tag="PVK74_RS30070"
                     /old_locus_tag="PVK74_30070"
     CDS             complement(21133..21381)
                     /codon_start=1
                     /db_xref="GeneID:91360492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007321360.1"
                     /locus_tag="PVK74_RS30070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30070"
                     /product="hypothetical protein"
                     /protein_id="WP_274477752.1"
                     /transl_table=11
                     /translation="MALDAVGQAAVNVEFVVVSSEPEAAAAGLAGSPTFLIDGVDLLGN
                     EAVPAGLTCRVFRTESGSLAGLPEVADLARALRKRVV"
     gene            complement(21568..22452)
                     /db_xref="GeneID:91360493"
                     /gene="lgt"
                     /locus_tag="PVK74_RS30075"
                     /old_locus_tag="PVK74_30075"
     CDS             complement(21568..22452)
                     /EC_number="2.5.1.145"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008961 -
                     phosphatidylglycerol-prolipoprotein diacylglyceryl
                     transferase activity [Evidence IEA]"
                     /GO_process="GO:0009249 - protein lipoylation [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91360493"
                     /gene="lgt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074988.1"
                     /locus_tag="PVK74_RS30075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30075"
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="WP_187691560.1"
                     /transl_table=11
                     /translation="MILTYLPSPSRGVWHLGPLPVRAYAFCILAGIIVAVLITRRRWVA
                     RGGRAEDVLDVTVWAVPFGIIGGRLYHVITDPELYFTAGHHPIQALYIWDGGLGIWGAV
                     AFGALGAWIGCRRRGIALTAYADALAPGLVVAQAIGRWGNYFNQELYGRATTLPWALHI
                     DPAHRPADTPTVALYHPTFLYECLWDLGVAGLVIWAERRFKLGGGRAFALYVAAYTVGR
                     AWIEALRVDHANHILGLRLNDWTSLIIFLAAVLYLWRGPRTANDPATRVSTPDEPAPHP
                     SNASEDKDAVQPR"
     gene            22605..23834
                     /db_xref="GeneID:91360494"
                     /locus_tag="PVK74_RS30080"
                     /old_locus_tag="PVK74_30080"
     CDS             22605..23834
                     /EC_number="6.1.1.13"
                     /codon_start=1
                     /db_xref="GeneID:91360494"
                     /inference="COORDINATES: protein motif:HMM:NF013565.4"
                     /locus_tag="PVK74_RS30080"
                     /note="mycothiol biosynthesis; catalyzes the ligation of
                     cysteine to a mycothiol precursor; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="PVK74_30080"
                     /product="cysteine--1-D-myo-inosityl
                     2-amino-2-deoxy-alpha-D-glucopyranoside ligase"
                     /protein_id="WP_274477753.1"
                     /transl_table=11
                     /translation="MGALGAACGAGRRVRAHHGVMTSSHAAGTVFSNHPGQGAAGSGAA
                     LRLSGAVVPVVGTARVYTCGITPYDVTHLGHAATFVWSDLLASVWRLAGVETLGCRNVT
                     DVDDVLTRAAGLRGSDFDQFALQQEYLFDKDMTALRVRRPAHEPRARHHISAVQQLAGA
                     LLAGGRAYLRDGFVYFRGAQVAAACGLSRAEALARSSEYGDDPQDPRRDDPFDVAVWRP
                     SGEGQPAWPSPWGPGRPGWHAECAAMALSVFGPSVDVLAGGEDLVFPHHAYQAAMVEAV
                     TSVAPFARARLHVGAVHQDGTKMAKSTGNLTLVADLLRDHSPAAVRMLLLDRPWRSVWQ
                     YRPGDLDTAAARLEQLYAAAGRPGGTGEAAIGVVVAALLDDLDVPQAVEVAVDAGGDAA
                     RLLLRVLALA"
     misc_feature    22740..22742
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(23805..24326)
                     /db_xref="GeneID:91360495"
                     /locus_tag="PVK74_RS30085"
                     /old_locus_tag="PVK74_30085"
     CDS             complement(23805..24326)
                     /codon_start=1
                     /db_xref="GeneID:91360495"
                     /inference="COORDINATES: protein motif:HMM:NF016107.4"
                     /locus_tag="PVK74_RS30085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30085"
                     /product="methyltransferase"
                     /protein_id="WP_187691561.1"
                     /transl_table=11
                     /translation="MHAAPHSGAGSRPQIIAWSLVAAQLLLIAAVAVAPARPGWPVPWP
                     VRLAGAAVTVAGAVLAAAAAAGLGRGLTASPLPNDAARLRTTGLYRRVRHPVYSGLLLA
                     AAGWIIASGSLPRAIAAVALAALLAAKSRWEETQLTRRFPDYPAYAARTPRFMPRPWPR
                     RSRQGQHPQQ"
     gene            complement(24336..24920)
                     /db_xref="GeneID:91360496"
                     /locus_tag="PVK74_RS30090"
                     /old_locus_tag="PVK74_30090"
     CDS             complement(24336..24920)
                     /codon_start=1
                     /db_xref="GeneID:91360496"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020519255.1"
                     /locus_tag="PVK74_RS30090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30090"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_274477754.1"
                     /transl_table=11
                     /translation="MTTSAPDRLDVTALFQRLTGGGQVSIVDVRTPAEYETTHIDGAVN
                     VPLTVIESHAPQVAARLDGDVVLMCQSGTRAEQARRRLTAAGAGGLRVLDGGVEQYAVT
                     GGDIVRGRARWSLERQVRLVAGGLVLAGLAAGLRAPKARWLAAGIGAGLTFSALSDTCT
                     MGRILSALPYNRGPRDHTPAEIIDRLPAITA"
     gene            complement(24954..25787)
                     /db_xref="GeneID:91360497"
                     /locus_tag="PVK74_RS30095"
                     /old_locus_tag="PVK74_30095"
     CDS             complement(24954..25787)
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91360497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019031702.1"
                     /locus_tag="PVK74_RS30095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30095"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_274477755.1"
                     /transl_table=11
                     /translation="MILFAAAGLGLLIGAVLGALGGGGAILTVPALVYLLGQNPQDATT
                     SSLIIVGLTAVVGAVGHARSRHVRWPTGIAFGVAGIAAAVAGTAANRHVEPHILLLGFA
                     ALMTLAAIGMLARARHEPAAPHDDEPDPSTGSTSRTGTAQLTRAAAPARSRTGTAAKVV
                     IAGLLVGFLTGFLGVGGGFVIVPALVIVLDLPMPVAVGTSLLIIAINSAASLAARTGHA
                     HFDWTIIIPFTLAAMAASLAGKKIADRLPQTVTTRAFAVLILAVAAYTAGHTLLT"
     gene            complement(25784..26125)
                     /db_xref="GeneID:91360498"
                     /locus_tag="PVK74_RS30100"
                     /old_locus_tag="PVK74_30100"
     CDS             complement(25784..26125)
                     /codon_start=1
                     /db_xref="GeneID:91360498"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018796084.1"
                     /locus_tag="PVK74_RS30100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_30100"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_208812871.1"
                     /transl_table=11
                     /translation="MTTPEVTDVDAATAEKLVSEGAVTLVDVREPDEWAAGHAPHALHL
                     PLGSLNPADVPAGRPVIAVCRSGKRSTIATGKLLAAGLDARNLTGGMTAWAQAGLPVRT
                     DDGREGTVA"
ORIGIN
        1 tggcgcatgg atccattcgt cgctcgcggc cgggacgggc gatggcggcg ctctccggtg
       61 cgagccgtcc cagccagaag acccccgccg ggtcgacgtc aagcgtctcc gtgtggtcgc
      121 cgcggccctc tgcggtgact cgctcgtcga gccaccggac gaaacgagtg tgcgcttcgt
      181 ggcctctcat gccgctctcc ccaacaccat ctccgccaac gcacgaacat ctcggtcctt
      241 acggaggact tcgaaaatct tcgactcgag ctggcgcact cgttcccgac taatgccatg
      301 ctcgatcccg atggactcca gcgtcgcctc gtcctgatcc ccgaagccga agcgggcctc
      361 cacaatgcgt agcgaccggg gatccagaac ctcggtcagc cgctgtcgca gcccaaccgc
      421 gacatccgat gtgacgacgg cttcctcggg accaggctcg gtagccacca gcacaagatc
      481 accgagagtc gcttcgccgt cgacggcggc cacggaggcg tcgagatgaa cgaccggtga
      541 agaccaatcc aggagcgcct gaactcgtgc cgggtcttcc tgtacgccac cggcgatttc
      601 ggcgaggctg gcgggacgac cattccgcgc ctcgaaggag cgcgcgtagt tttcgacctt
      661 gcgaacctgc tcccaaacgt ggacagggag acggacgagg gttccggtgt cggcgatcgc
      721 gcgctccacc gactgtcgaa tccaccacga cgcgtacgtg gagaacttga aacccttctc
      781 ggggtcaaac ttctcggccg ctcgatgaag acccttgacg ccttcctgca ccagatcatc
      841 gaagtccagg tcgcccgacc ggtgggtgta cctgcgcacc atgctgatca caaggcgaat
      901 gttcgcaagg atgagggcat ctcgggcctg tcggccgtca tcgatcagag cctgagctgg
      961 cggggcggga tcgattccca ggctggccgc agtctcagcg gcggcgaggc cgagttggat
     1021 gcgcctacca aggttgacct cgtcctccgc tcggagaacg gcgtggatcc gcatcgacgc
     1081 cggcaaggtg gcggcgtcgc gtccagccga cgtcccgccg tccggcgcga tgccagccgg
     1141 cgcggcgacc tcgaccccga ggtcgcggag ggccagaacg atctctggca aagcgtcacc
     1201 gaggccgcgt gccgtgacga cgcgtaccac gtcggaccac tccagcttcc ccgcccgctc
     1261 cgcgtcgtcg gccagtacgg ccacgcagcg gacgaagttg tccccttcgc tcacccgaac
     1321 gtctcctcca tgtcacgttt tcgccccaac aacccgcagc ctgaagccgc tcgggttggt
     1381 gacgccccgg aaggccacgc cttcgcctgc ccacgagaaa acatgcagga gcgcaactcg
     1441 ctccgcaagg acacaagggg ggcaccattc gcgtgtgtcg acctcaattg tttgggctcg
     1501 cggcaaaagc gcattacgcc cgaagcgttg acggccgatg cgcactccga taagttcttg
     1561 ccgtagcccg cgtataggca cggcccgctc ggcggcacgt atgccctgct cccgacgttg
     1621 ctcgttctcc cgtaccaccg ctcacttgag gcttggagct cggatgcgca ggtcggccag
     1681 gcacctatcc gctgtccaag aatcacccgt tcgggtgatg cgagtgccgc tcggtgaatg
     1741 cggattccga tcgcgatagc cgcagggggg cgtgccgtct tgaaacgaga acatgcgcga
     1801 cgcacgccgg caacgcttgg ggcgacgtcg actgccgcgg cgttcctagc tgccgccaac
     1861 gcgcataggg agctagctgt cgtcgggaac tggtggaggc gtgggcgggc cgcgagccgt
     1921 cggctgcaga atggaccgac ctaacggtgc ggcgttgacg atgtcactcg accctgcgga
     1981 acatgaacat ggcgccgacc agagtcgcgc ggtgcccacc ccgatcgccg cgccccgatc
     2041 aggcctcgcc atgtccttgc tcctagctgt cggtcctgac gacacggaaa agttgtgcca
     2101 tgcggttggc gccccaggtc tgacgtgtca gactgcggaa cccagatcgg cgagctcgga
     2161 ggcggcgttg acagacaaat gggcggctga ttttcgcctc agcatcaccc gcgcactcgc
     2221 cgaccaactg gaaaccaccc tgcggcccct caagcccacc cccctgacag cggccaacct
     2281 ctccgcggtc ctaggtcgtc ccggcgtgta cgcgctgttc ttcaacgaac ggcgcgtcta
     2341 cgtcgggaag gccgccaaat cgctgcagga ccggctcacc caacatctcc gcaagctgtc
     2401 cggtcgcact gggctcgact ccgcatccgt tcgattcgtg tgcgtatacg tcgatgagga
     2461 cctcgacgcg gcagcgccgg aaaagctgct catcaagaag tatcgggagc atgacagcat
     2521 cccgtggaac accaacggtt tcggaaataa ggacccgggc cgcaatcgcg acacgagcgt
     2581 ggtcaaggcg gcgcacttcg acgccaccta tcccattgat cttgactacc agtgccgtca
     2641 ggagccgggg atgcagtcgg tggcggccgt cttggaggcc gcgaagggcc agttgcccta
     2701 tttattgcgg ttcgacagcg gcgcggcggc caagaagact taccgtgaca ccttgatggt
     2761 tgtgcccgcc caacccttgg ccgcgagaga cctcgcccat cagttggtcg ccgctctacc
     2821 cgctggatgg cagctgacgg ccttgcctgg ctacctcatc ttgtatcaag agcgtcgacg
     2881 gtatgacagc gcccttggct ggtggcgacg ggagtcggac ggtgacgtgc agtacacccc
     2941 gggtccccgc cagttcgcag caggtgcggt ggacgtggag gcagcggacg tgagtggtgg
     3001 cgacgccact tcgctcttcg agctcgacgc gtaactttga cttagtgaga ggcatcgatc
     3061 gcgaatgccc accttcgtcg attacgtcga gataagtctc gccgccgcgc gagagcagtg
     3121 gcaggccatt cttacgcgca caccggtcac agccggccgg caggtggcct tccttcctgt
     3181 cgagacgttg acgtgccttg ccgcgagcct gctggtcaac caccgcaagt acggcggctc
     3241 gaccgcgcat agggccgagg cgcctgtccc cgcactcggg cgtctgtttc aacgccccaa
     3301 cagcagcgtc ctggcgaaga tggcgaacct tgacggcagt agacgcaacg gcgccaagta
     3361 cgagatcgag gtagcggctc atctcctcgc ggttccgggg cgcctgggcg ccgtctaccg
     3421 ggtcatactc gccgcagcgc gcgacgtcgg tatcgactca gagaacctcc cagactttct
     3481 tggcatcacc gacgacgaca ctgaccttcg gcttatcggt caggacgaac tcgaagcagc
     3541 ggaagtcgag gaggccgtac aggcgacgtc gactgcctgg ctcgagtcgc gcgccgatct
     3601 cgacgaacag accacagaac gcctcctggt cgccgctgcc cgcatcggtc agcaccgatt
     3661 cgccagggag gtgctgcgta accacggtca ccgctgcgtc ttctgcggcc tgtcggtgaa
     3721 ggtggcaggc gataaggctc cccgcatgct ggttgccagt cacatcaagc catggcggac
     3781 gagcaccccg gccgagcgcc tagacgcgcg caacggcctt accgcctgcc ctacgcatga
     3841 cgtcgccttc gacactggac tcatgactgt caacggcggc ctgcgtatcc atctcaagcc
     3901 ctcactcgcg cacgctgtac gcatggacac ggcgacccgc gccgctttcg gtcgaccgcc
     3961 gttggctgac cgtctcctcc tacctgcggc cgcgccgcct ccgcgggcga ggtacctaac
     4021 gtggcaccac ctgcatatct atggagatac accatcgacg ccatccgatt ctccacttcg
     4081 gtaggcgccg tccggtcctc ggggttctcc gcatccgtat cggcttgcgg catgggtcgt
     4141 ccattcgagg cgtcaagccg ccgtggttcg ccgccacgta cagcgatcaa ctactcgcct
     4201 cgtgagaaaa atcaagatga caaagaggat cgttctggac gagcccgccg gttggaagcc
     4261 gcctcccgga ccgcggtcgc gacgcgatcg gcggcctcgg tgggattctc gtgctcccaa
     4321 atcctgatca cggtccagcc ggcttcggtg agtagtccat tggtctcggc gtcgcgggcg
     4381 cggttcccgg cgatcttttc gctccagaag cggtcgttgg cgcgagcggg acggtaatgc
     4441 tcggggcagc cgtgccagta gcagccgtcg atgaacaccg cgacgcgagc tgcggaaaag
     4501 acaacatcag cggttcggcg caggccggcc attggtctgg cgttgatccg gtaccgcaag
     4561 cccatcttgt gcagaagcga gcgtactcgt cgctccgggc ctgtgtcccg agccttgttc
     4621 gcgcgcatga cggtccgtac ggccgggctc ttcgcccaag acgatgaggc ggtgtccggt
     4681 ggggtgagaa ggcctcgggc ccaggccaac cgccatccct cggccaggtt gtcggcccgg
     4741 gtgtcgtgtt cgacctcgcc caggtatcga gcaggcgagc gacccctgtc ggaccatcgc
     4801 agataggccc gaatccggcg agttcggggc agtagtttga ggtccacgga ggcgcgggcc
     4861 cgacgtccat cgccgaggtc aacccatcgc cgatcgggtc ctccggcggc acggtcttgc
     4921 tccagggatg ccgcctttcg gctgcggccg cgccggcccc tccaggctct tgagtctggg
     4981 ggcttatccg cccagtgact ctctgatctg gcggaagtga tggtcaccgt tggctctcgg
     5041 cctcgtcgag cgctgcggcg atggctttgg cgaagaactc gccgaggaca acgggtacag
     5101 cgttgccgag ctggcgcatc ttctcgcccc gaggaccagc gagcagccaa ttgtccggga
     5161 aggtcatgac gcgcgctgtc tcccgtaccg tcatgtaccg atgccggtag ggatacggct
     5221 tctcgccggc cggttcatgc cacaggtcgt cggtcagcat caccgactcg ccgccaggga
     5281 cgccatgcac tcctgccttg accgtcttgg cgggtcggtc gagctcgttc ggtgtatggc
     5341 cggcgtaaat gcgcgcgtct ggccagccga tgtggtcggt gaacccaccg agattgtgct
     5401 ctcgccgatc gagccagtcc caaggcacgg gtggaagggg gggctgtccg tcaagtcctt
     5461 ggatggcatc tcgcagggtt cgccacggca gtctgccgtc atcctcggga ggggtggttg
     5521 gcagtcggga catgacgcgc tcgcgtacgt gctcgggcac ctggggatgc ctccgccagt
     5581 aggtgccgtc gagcatcgat cgaatcagcg ccgcctccga gtatcgcgga cgcaccgacc
     5641 gcttgaagcg ctcgatgtcg actcccaggt ccgatcgaaa cgccacgatg atgatcctgt
     5701 tgcggatctg cggaacgccg taatcggcgg cgtttaccgt ggtggtgacg acgtcgtacc
     5761 gccgcttggg gtccgggggg tcctcggcca ggcgttcctt gagcacctcg tcatggtcgc
     5821 gccaggtcga gtcgtggtca cgctcctgga aggggagctg caactcgcgc tcgatgtact
     5881 cgaagtacgg tcgaaaggac gggcgcagca ggccgcgtac gttctcgcac atgacggcct
     5941 tgggctggat cttgcggatg gcgcgaaaca tctccgggaa catgttccgc ttgtcctcgt
     6001 cgcccctcgc gacgccgccc aggctgaatg gctggcatgg gggtcccccg gcgaggagat
     6061 ccacccgatc ccataggtag tcgaacttga ccccgctgac gtcgcccctg gccaacggcc
     6121 acctctcgcc ggggaggggc acccgctcgg tctcgccgcg gtcaacggcg gcgttggcct
     6181 caagtgtgtc gcacgcgtac ttgaccagtt cgttgaccag gaggggacga aagcccgctc
     6241 ggtgaacagc catcgccaag ccgccgccgc cggcgaagag ttccaccgag gtgcggtccc
     6301 tgatctgctc tccgggcggc tcagacatga ggggagcata ccgcggagtt gtcgatcttg
     6361 gaaaggcgaa tcgcgcgttc gtcgcggccg ccgggtcttg gtgtcggctg agtccgtccg
     6421 agccgcggca tccgcgcgac tcggggtgtg gttgggtatc gccatcgtga ggagggcgat
     6481 ggcaacttgg cagttcggtc cgttcgacaa cgacgacgcg gttgagtggt gcgatgccct
     6541 agaggccgcc cccctcgacc aacgcgtcga actcgtacac gacacccttg cggtcgcggt
     6601 ggccgggcgg gccctcacgg cgggggaagc cgctcgagcg gtggcggcgg ccgccacggc
     6661 gctccaatcg ctcaacggcg tgccgttctc gaactcggcg tacgctccac gcttcctgtc
     6721 cgacaaaggg gccatggcag tcgattcatc aattcgagac ctggccgtgc aagcgctcgg
     6781 cgaagtgctc gcgaacggtt cagcctggcg gctgcgatgg gctgacgaca tcgaggaaga
     6841 agaggctctc gctgtcgtcg aaagccttcg gagtcacctc gtatcggcgg taacgccgta
     6901 gtcacacatc gttgggcatg ttctcgtcaa aatctgcctc aacaggtatg tctttcccgg
     6961 cagcggtggt gaaactagtg ggtgccagct gtgcaaggtc accaatgacg ccccccacga
     7021 ttgactcgag ggtcctgtga ggcggcaccc gtcggaagtg gacatcgatc tcctttcgga
     7081 tcaggctctc cggcttctga tcctcggcga gtgcgtccgc ccactgcctg cctgggtgga
     7141 gcgtgtccca aggtgatcgc ttgttactgc gggtctctgc attatcgcca tgcttgctca
     7201 ttccggagca gatcttcgta tcgttattcc aaatcggctg gaaaaactgt atgagctgct
     7261 cctcggccgc gctctgatac cccgtctgca cgatgaggaa tcggcactcg aagtcctcca
     7321 ggcgcaaggt tgacgtggcc ttctggatgc tcttgcggtg atcgttcaaa cggcgatgca
     7381 gacgcgttcc ttggcttacc gcgtccttcg cctcggcgtc ttgcgggtcc gccttgccga
     7441 cgtatatcgg ctgctccgtg cgggaaatcg gcgaatacgc gtcaaagggg ccgttgtagt
     7501 acagcgcgta caccccggct ccatagaaag gcctgagggc cgccagtgga tgcctctgct
     7561 gggcgatcat ggtcagcgcg acgatacgac ccgtggtgct gggagcgctg ggatcgaaca
     7621 ggcctcgtgg cctcaagatt gggtcgaggc gagtaacggc ctggtccagc cgcttcgcct
     7681 cagcggcgag ggccccacgc agcgcgttgc gggtggctgt gtgacggggt ggatggatcg
     7741 cctgcaactc gtcggcgatg gccgcaagtc gctcgacgag actttggcgg cggtcgcgcg
     7801 cccgaggact cggcgaaggc acgccttgag gctacagggc tacccgggtg acttccttgc
     7861 gcaggtatcc caggcctcgt cgaccagact ccacagtgct tggcacggct ctgccttcga
     7921 gcagcatgtc tcctgatggt aggtgctcac gaggtatgga cgaccgaatc gcgaggcagc
     7981 tctgctgcgc agggctttgt agacataatt gtcattctgt gggccatcgc ccaggcaccg
     8041 ctcccgtaac ggcgtctcgc ggtagtcatg aaggtctggc gtcaccgccg gcgcatgacc
     8101 gcgtagacca tcctgctcgt cacctgccgg tagccggcac gggtccaagg tggtgcgggc
     8161 gcggtcgatg acggcggcgt cgatgtcgac ggtggcgacg gtgccgcctg gtccgaaaat
     8221 gtcggcgatc agcgcggcgt tgtagccacc ggagccgacc tccagaaccc gggcgccgag
     8281 ctgaaggtga gcggcgtgca acatggcggc ttgaagccac ggctcggaga tcgaactcgt
     8341 cgcgcgcccg tccgggccgc ggctggtgat gattacgtcg ttggcgtagg cgacgtcgag
     8401 gctgatgccg tcggcggcga acagatgtcg gggcacccgg tgaaacgccg cccggacccg
     8461 ccggtgaggt gatccactgg tcggcgagga gttggtcgac gagcagagcg ctggcgtcat
     8521 cggcaggcac ggtgtcgagc gcagaaccag ccatggtcga cctccgcgaa cgggcgtcgg
     8581 aggatgcgga ttcgcggcga cgatatcggg cgcatgtgac aaaaagcgcc tggcccggtc
     8641 gcctcgtggg aggtccccgg ccgacccgtc cgtcgccctt tcggaaggcc gcgagcgcct
     8701 ggctgccgcc gcgcctcacc gtcgtgcgga cgtgaaatcg actcatcggg ttttccgcgc
     8761 ggacgtagga ttcaacgggc ggtttaggtg ctgtgaatcg cggttccggc gagggcgagc
     8821 gccgatgaca aggtccggcg ggccgagtcc ggaagtcgtc caaggccgag gccgctcgcg
     8881 ctgatcatct gcctcagcgg gccgtggtat tcaggaccaa cgcctggacc tttgagaagt
     8941 tcacgcgcgg cgttggcgtc ctgctcctgg aaaacctctg cgaccatgcg atcgatcacc
     9001 gccgttgcag cggctgtgca aaggtcgggg gaaaggtcga gggcggtgag gactagccgg
     9061 gtgcgaaata gcgagagccc cggacctgtg gccatagttg atgctcggtc gatcagttct
     9121 ctgtggtcgg ctaggcttcg atcgccgacg gtggctgcgc tccaggcgtg taggagatcg
     9181 cgtaccagtt cctcccacgg gtgctcgatc gtggtgcggt tgaggatggc ggtagctgtg
     9241 cgggtgctgc cgtggatgag gtgggctacg acggcgacct gtcgcccgtc gtgcagagtg
     9301 gtcccgatcc cgtcgtagcg ttcgacatgt ttcaccgcgt cggcccaccg cccgccggcg
     9361 gtgagcgcgc gggttccgtc ggacagcagg atgttgcgga gccagctggt gatctcctgg
     9421 cgttcctcga cctttacggg gagctgccga ggatgtatct ccaactctcc gatgacgatt
     9481 ggttcgctgt tggcgaccgc atggtagagc gcggtgagta gctggtgcgc cgtttctccg
     9541 tcgccgacgc ggatgcgcag gcgggcgaga ttgacgactg gttcaagggc gaagcgggcg
     9601 gtgtatccgt tgagaggggc gcggctgagg tagaggcgcg cgtgatggtg gcaccagagt
     9661 tcggcgagtt ctgcgtctgc acagtcggag gcgacgagag cagcgccgtt gaacaccatc
     9721 gacgccttct ccggatcgtg ttcgcggtgg gcggtctcgg cgagcccggc gaggcgtgtg
     9781 acccgtgcgt cgagcggttt ggctggcggg cgtctgcggg cgacgagggg gaaacgggtg
     9841 gcgatgctag gggtgaagga caggggcatg attgtcctca tctgctgcgg tggccgcccc
     9901 acgggcgaga cagggtatgg atgcctgcgg tgacgcttcg cacgcttgcc gcgctccctt
     9961 cgggcctccg gggcggggcc accgtcccgg cggcgcacgg tcagaacgag atcgtgagag
    10021 tggtgtcggg tcggctgatg tcgccggtct ggaccggtcg ggttccggtg cggtgggcgg
    10081 tgacaatggg ctgattcggg cggcccgcac tgtcccattg gtcgagcagg tcggtcagtt
    10141 ccgcggcgag tttgtcggcg tctgggccgt tggcgatggc gccgagttcg tggtggccgt
    10201 cgctggactg ttgaaaggcg aggtaggcga tggtgccgcc gtcgtagatg gcggctccgg
    10261 cccaccggta ggcgggggtg agcagtccgc tggtgcgggc ggtatcgcct gcgcggaggc
    10321 ggccgaaggg tttgctggcg ttgacgagga gccacaggtc gaggtggccg atggggtcgt
    10381 cgtcggtgac ctggataccg gtccagcgtt cgtagcgagg gtggctaagg gcgcgggcga
    10441 gggccgcgcg gtcgggttgg tcgttggcgt cgagtttgag ggccgcatcg gtgtcgaggc
    10501 ggacgtgctg gtcggtgtgc tcggccgcgc cgcgcagggg cacgaacccg cagaccagcg
    10561 gtgccgtggt gctgaccagg gtggtggggt cggcgcggtc gaaggcgaag catcgggtca
    10621 gaccgctttc gtgcacgcgc aggggcacga ccaggcgacc ccgctcggcg agttggtccc
    10681 accaggccgc ggagatgtcc cacgcgccgg cggtgacaat gatccgctgg tagggcgcgg
    10741 attcggggtg gccgagggct ccgtcgccgc agatcacctc gacggtgtcg tagccggcgc
    10801 ggtcgaggcc ggcgcgggcg ccgtcggcga ggtcctgatc gagttcgatg gtgacgacca
    10861 tgccaccggg gttggtcagt tccgcgagga gggcggcgtt gatgccggtg gccgcaccga
    10921 tctccagaat gtggtccccg ggttgcgggt cgagctgttc gagcatgtcc gcgacgaggc
    10981 tgggacttga cgccgacgac agcgcggcgc ctgtggggtc gcgtttggtg acgatctggc
    11041 ggcgggtgta gaccgtctcc agatcgacgc cgggaaggaa ccgctcgcgg ggcaccgtcc
    11101 ggaacgcctg ctcgacacgg gcggagcgga ggtgaccgcg ctgtttgagg gtggtgacga
    11161 gctgctcgcg cagttcggct gcgctgaagt ccgcaggatc ggctggggag tttttcaccg
    11221 cttttaccct actgtcggtc gagccggcga ggtggtagcc gggcgggatg gtggacgtat
    11281 ggaaggtgac gtgcacggcg gctgtggcca agtgccgcgc gtcggccgcg gaaatgccga
    11341 gccggttgaa cagaaacagg atgtggtagg tcagcacgcc gcgtaggtcg cgggtcagcg
    11401 tgccgtgccg gtcgaggaac ccgaggtctc ggcccgcctg ctcgtgagcc ctcgaccact
    11461 gcggggttgc gctcaatggg ctgcgcggcg cgtcgtcggc ggcggtgagg aggcgctgca
    11521 tggcggcgat cagcccgggg ctgggcgtgg gtgcctgcgg ttggtgccgg cgggcagcga
    11581 ccttgtgcca gacatcgcct tgttcagaga attccaggcc ggcggcgcgc atgaggcggg
    11641 tggccagcag cacgccgagc tctcgtcggt gatcgccgcc ggcggcgagg tgtccgagga
    11701 tgtggcggct gtcggcgtgg aacagggtgt gagcgatcgt catcgcgtgg tcgccgccga
    11761 aggcgtacgc ctcgggccgg tagaccggct cgacgacatc tcggatgcgg tcgtcggcgg
    11821 tgatgtcggc gagcagccag tagaaccggt tgagctgacc tccgggcagc agccgcagtc
    11881 tccacgtctc ggtcttgcgg atgaaccaga acgcggcggt cacaccgtcg tcctcggcga
    11941 cggcgagcgc cggggcgagc cgggtcgcgg cgtactcctc agcggctcgc cagctcgcga
    12001 agctcagatt gacctggcgc caccggctga ccggcgcgac gcctggtggg gcctcagtat
    12061 cggcttcggg atcgaggtcc atgaggtgct ccttgtctag gtgatcagca ggctcgtgga
    12121 ccagtggatg tcggttccgg tcgcgaaggt gtgcagggca agggcgatgc cagccggccc
    12181 cgagatcagg ccggacgacg cgggtgtggg gtcggtggcg tgctggacca gcagacgcat
    12241 caggtagggc accgaggcgg gtaggcgggt gtcgcgggcg tcggcggcgg cgtaccagag
    12301 tgtcgcggcg aggcccgccc agccgtgaca caacgacggg tcgatgatcc ggccgagctg
    12361 gacggggtcg gccacacagc gggccagcgc gtcctccgcc gcctgctgcc ggtcggagtc
    12421 actgagggcg ataccggcga gctgcacggc gcgggccatc cccggggtgc cgtaacacca
    12481 ggacgggcgc gctggtccag tgatggcggg ccgcccggcg cgtaactccg cgacggtgat
    12541 cttctcgggc caccgcgggc ccgccgcgtc tgtctgctgc catgtgtcca gccacgagca
    12601 gatccggtcg attgcctcgg actgtcccgg cacccggatg tcgcgtcgca tggccagcga
    12661 cagcagggcc aggggaccgg tgatgccgtg cgccatgccg acgttggcgt gtccgccgcg
    12721 ctcacggctc tcgccgttgc tgggtgggtc cgcgctccac caacccggcg cgagcaggcc
    12781 tacggcgtcg tcggcgtcga ccggctcggt gagccgcacc aaataggcca gcacccggcg
    12841 cagcaggtca ccgtccgggg atcggcgtag caggtgggcg cccaggccgg tcagcccgcg
    12901 gacgaggtcg aactccgcca accgaggtcg ggcgctggca gcgaggcgag cgtcggcagc
    12961 ggtgagccga tgctcggtaa ggtccgcgac ggcggtatcc agcgcgttga gggcagcagg
    13021 tcgggcgtgc ggcatggccg tggtcagcgc gtgagtgacg gcgggtgcac cgaaccacag
    13081 gcccgctccg gtgccgttgt tcagcgtctc cgcgctcgcg tgacgcagcc aggcacggac
    13141 cggttcccat tcaccgtgcc ccgtctgcgc gcgcaccccg tgcaggatcg ctaccccggc
    13201 ggcccccttg gacagcgatt ggccgtacca gcgggtgctc cgcggcccgt agtcgacccc
    13261 gtcgggtagc gccggcggct ccatcagggt gtcgctgatg caggaggcca tcgtctcagc
    13321 cgctcgtagg agcggcgtgg caagcggcgt aaccgtcatc gggcggctcc tggtgtaggg
    13381 acacggcgac ggaccgtggc cagcgcgatg tggcgggcga gccgataggt gacctgctcg
    13441 gcggcctcgt ccgggccgtg cgcgcgaacg aagtgcagat gcgtcagcga cgtgagtacc
    13501 gtcgcagggg tcagcggtcc gctgaaggcg gacaacgcat cggcgtaccg gccggcggcc
    13561 tgagcgcgtt cctgccacgc acgctgaacc tcgtctggca tgagcgtcgg atcgagggcg
    13621 accgcctggc gcaggacgcc ccgatcgatt ggcgctcgtc cggcgtgctc cggccgggcg
    13681 acaagccact cgcatccgct ttcgcggcta ccaagcattg cggcggccag gtcgagcatg
    13741 ctcgcggcgg tcagcgcctg cggtgcgatt tgagagtcct tcgctgccag ctgggctagg
    13801 gcggcacggg agtccgcgcc gaacagctcc tcggcggccg acatggcagg accggtgccg
    13861 taccggccgg tttcgggacg ataggtgtcc aggcgcagat cacccgcgag tccctgccgc
    13921 cgaagcgcga ccgcccaccg gccgactctg atcgccgcct gcccgtagtc gtcggtgtgc
    13981 agccgaagcc gcaggtgtga gtaaggacgg cgcatccgga tgaaccacca catcggcggt
    14041 tcgggccagt cggcgaacag ggccggcagc cctcgccgca acaccaactc caccgtcgac
    14101 gggtcgactg cgagggatcc ggacagtaac ccgctctctc ccggcagcac cgggtcagcg
    14161 ggcgcgcacg gcggccacga ggctcttgca gcgactgagg cgggcgccgc agccgcagcg
    14221 gcggtggagg cgaccggtac gacgatttcg tgcgcgcggc cggatagcca tccgaagtcc
    14281 tctgacccgg cggcctccac gatggtgatc cccgcgtccc tgttggcgtc caggtgcgcg
    14341 cgcaacagcg accggtccat ggcctgatcg aggtcgagtc gcagccgctg gtcgctgcgg
    14401 ccgacctgca cccacctcgg cagccgcagc cgctcccgca gcccgtccca cgccaccgac
    14461 catcggccgt cgctggcgtc ggcggcggga agccgcgccg gatcgatccg ccaccgcgcc
    14521 gcggacagca gaacccgtcc gtatcgcagg gcgggccgaa acggcagaca cgacgccgca
    14581 ccccagtcga acggcttgag tcgcgcgtcc agggcccgcg gcagctcgac gaggaaccgg
    14641 gcgagcagag gcatcgtgtg cacggcgccg gcgtgcgcca ccgtgggctc gaccacgcgg
    14701 cgccgcgaca tcgacaccac gacaagtcgg gcagcgtcgg cagcaacgcc gaggtcatcg
    14761 agggcaatca tgtcctcggc ggtcgggcgg tgctcggcca tgctgaccag ccatggaagg
    14821 acctgcggag agctgagcac gttctgggca tgaagcttgc gcggcgggaa gctcacctga
    14881 gccgccatgg caccttccac cgcgaccgga aggcgcgcga actgcccgcg catcagctcc
    14941 cgctcggcat atggcagcac gtcgaggaag cggccactcg tcgccacagc cgaccggccc
    15001 atacccgtca ccgcgacaac gaaccggcct tctgccagtg cgcgcaacga caccgcgcgc
    15061 acctccgccg tcacgtcgac atgcggactg acgctgcctc ctgcgtgatc ggggccggcg
    15121 agcgccccca cggtcgcatc gtcgagaatc agctctcgaa catcgtcgag cgccgcttgc
    15181 tgtgctaacg ccagcaggcg ctcgtcccga gcggacagcg gagccgccag gtcagcatcg
    15241 ccgaagtgct ccgggaagcc gagaccggtc actggatcga caacctcggc aagcggcacc
    15301 agcgcagcca tgccgtaccg atcgacgaac cgggagtggt aggcgcgcca ctgggggcgc
    15361 cccgtcggat gcggcgtcaa tcgccgcagc acctccaccg acgcgacgac ctccgcggcg
    15421 acctgatgcg gcacaacgac ttgatccgcg agccgaagat ccaccgctaa cggctgtgca
    15481 actaccgcca gctcccgcat ccgagcggtc agcccaccaa ggtctatcgc ctggcccgtg
    15541 gtgacaccga ggtgaccgtg tagcgtccga agtttcttga ccgtttgcct gacggattcg
    15601 acgtcggggg ctgcgtcgag ctggtccagg aggtgcttga tcgggtcggt gcaggtagac
    15661 ggcggcctca gggacgagat caacacaccc tgctcgacca ggccggcgac cagagcctcg
    15721 accgaggcac gcgggaactc cagatagccg gcagcgatct tgtcgacgag ctcggcccac
    15781 cgcaccggct cggcgctcag agacatcgcc agccgcactg cctcggtacg cctcaccgac
    15841 gagatcccgt cggcgggcac ggaggcgtgg ggccggcaat gcacgacgat ccgaagcccc
    15901 gacacctgcg ccaggttgtt ggcctggacg gacagcccgt tgcgcacggt cggatcggcc
    15961 tccaggagcg cgatcaacga cgccagccac tccgcgtccg gccgcacacg gatcgctgac
    16021 cgctccgacg gcgtcacggc ggctaccgca tcgaggcgta gcggcgcgac ccccgagaac
    16081 aacccgaacg gcgtcgctcg accccgggcg cgggcccggt accgtgccac tgccaacgcc
    16141 atccgccacg cctggccggc gtcgagcctc gcgtcagcga gagccgcctc gacacggtcg
    16201 gcaagtgcgg gacttgccac ccagaccgct tccgagaccc cgacctgacg ccaggtcgct
    16261 cgaagccatg actcgacacc ggcaggatca tgccggtgcg gccagggcgc ttcacgattc
    16321 ggccagacgc gagccgcgat gcgaatactg gcggcatcta ccacacggaa catgaccgcc
    16381 ctccagccgt cgatgagtct ccttgcgcgg acctgcctcg tgtggcgccg gttccagccg
    16441 gcggctgggg gaccaccggc cggaaccggc cggtacgtcg gactagcagt cgccgcccct
    16501 cacggtgtcg cagccgtcgt ccgtgtcccc cagcagcgcg gcggcgaccg ggccctccgt
    16561 gacgatctcc acgtcgagct ggaacggttc accgctgacg gcgagcaggt tctccatgac
    16621 tggtccctcc aacgagactt cgatgggtgg gcaggcagac cttgcggcca ccagcccgtg
    16681 ggctacttcg cgtttcctcc gcagccggga tcgggtagcg ggagctgctg tcgctggccg
    16741 agcagcgaca cgtgccttcc ctgacttcca cgtcggttcc gaagcggccg gctgccgccc
    16801 tagagcctta ccggctacac atgacacgat cactcatggt tagtggtgcg ggaataccga
    16861 cttgcggtcc gacttcgtgt cccctcgcgg cgcgacagcg taagggctgg atgatcgaga
    16921 cagccggtgg catagtcggc agggctcagc aggctgggta aggggaactc gtgcctcgtc
    16981 atccggacac catgatcagt ccgaacaccg tgctcagcga cgcccggcat cggctgccct
    17041 cacctgtgcg acccggccag cgtatgtccc gtagcgagct agccgatgcg gtcaacaccg
    17101 cgctcgatcg gatctatccc gaccgcgacg tcaccgccca gtacgtcgac tcccgctggg
    17161 tcggcaagct ggaacgcggt gagcatcggt ggcccagcga agcgcggcgg acagctctgc
    17221 gtcaggtgct tggtgctgtc accgatgcgg atctcgatct ttacagccct cgacgtagcg
    17281 acggcgtaga agctgaaggg cctacggtcg agcctcagcc aggtagctgg gaagaggcca
    17341 tctacctcct gcgcgagcag tggcatctgc tggtgcagaa cgacaagatg ttcggtcccg
    17401 agtacgcact gatgggtgtc acgaggcaac tggccacgat cgagggcacc ctgtccgggg
    17461 ttccccaagc acttcgaccc gccgtcattc gactcgccgc ccagtacgcc gaatccgcgg
    17521 catggcttca ccaatctctc aacgaccacg ccgccggcca ccgccgaaca cgacaagccc
    17581 tcgcctgggc agacgagatc gccgacccac cgatgaccgc ctgggccacc taccgcagca
    17641 gccaacaatg gctggcatcg gggcgcgccg ccgaagccgt cgagcaggca gaggccgcgc
    17701 tgctgcatga cccgaagctt cctcgcccga tgcgcgcggc gctccgtgtg cagcacgcgc
    17761 acgccctcgc cgcggcaggt gagcaccaat cagccatgcg gctgctcgac tccgcgcacc
    17821 gctgggcagc ggaccgttac ccgggaaagc cggaaggcga gcacgcctcc tactgcacca
    17881 gcggatacat cgaagtacac cgcggggcat gccttcggct ggcacagagg ccccaggccg
    17941 cgatcgaggt actcgaccag gcgcttccgg caattccgcg caggcatcgc caggacttcg
    18001 cgtcagcact gctgctcaag gcgatggcac atgccgcagc acgccaaccg gatcaggcag
    18061 cggcagcggc acatcacgcg ctgccgatcg cacgccgagc gggatcgcga tgggtcttgc
    18121 atcagctcgc acaactcggt gccgcggtca gcggacacca gcagctacca gaggtccatg
    18181 ccttcctcta cgacctccag gagatgacct gatggcatca gacgtcgaac tcgcggcgat
    18241 gcgccaagcg atcactctgt cgtcgatcgg tctgggaacc acaagcccaa acccgcccgt
    18301 cggctgcgtc atcctcgatc gatatggcgt aaccatcggc gagggctatc accggtgcaa
    18361 aggagaagca cacgccgagg tcaacgcgct aagcgcagcg ggccctgcag tgcaaggcgg
    18421 caccgctgtc gtcacgctcg aaccctgcaa ccacatcggc gtcaccccgg cctgccggca
    18481 ggaactcatc gacgccggca tcgcgcgcgt cgtcatcagc gtcctcgacc cgacctcccg
    18541 gggcgatggt ggcgccgcgg tactcaccgc ccacggcatt gacgtcgaga ccaacgtgct
    18601 gcccgacgag acactcaccg tcctcggccc ctggctcgcc gccacccgcc gccgccgtcc
    18661 ctacttgatc tgggcatacg ccctcgacaa gcagaacagc cagcttgtca acgagcaact
    18721 ggccgtagat ctgcgaagtc gtacagacct cgtgctcaat gacaagaccc ttgaagaggg
    18781 agtccctggc ggtcacgcgc ccgaacactt cacgctgccc cacgacctga gcgctgatct
    18841 ccgatcgtgg ctgtcggcct gctacgccac cggctcacga accatcgtgg ccgttggagc
    18901 cgatcattcc ggcgcactcc acgagaacct tgactgcgtc gacgagatcg tgatcgccgt
    18961 caagaaagcc gcaccgacgg gggtcattgc ggcagccacc gcagacctca cgacggcggg
    19021 tttcgagctg gctgatatct cgcccgggag gacgtgcgtg cgtgttcgcc ttcgccggcc
    19081 caacgcgtct ccttaacgag tcgacatcgc acggccgggt ctgtgctgct gccgtagccg
    19141 gggtcggccg attcgctgcc tgccatacct agtacgcgcg taaacctaga acaggtacgc
    19201 cgagttgatt gctcggccag cacccacgcg cccaaccgtc ggcggcggcg tccctaatcg
    19261 cggtccgccg actcgcgtct accgtgaggt aatcacagat tccgctgacg acagcgacat
    19321 tcggcccaga tgcccgttct ccagcgcgct gatctgtcgc ctcggaaagc tcagcgcgcg
    19381 gacgatcgac ttgcccgtga catcatgttc ctcccgcagt cggcgggctt cacgtccgag
    19441 ccattgtcgg cggacatacg actagtactc cagccgggga tcgtgatcac ggctcgatga
    19501 gggcttgccg ggcgtagtgg ctggtcatgg ctttggcttg gtggcgacgt cggcggattg
    19561 accagagcag cgggtcgcag cgccggcggg tgggctcgat gatcaggatg tggaacaggt
    19621 ggcgtagctc gttgacggtc agcgggatca gcccgaccgg ctggtagtgg ttgcggtgct
    19681 cggcggtcgc ggcggcgagg aacgcgtggg cgaggatcgc cagggtgttc cagcggtgcc
    19741 aggaggtcca gcggcggtgt tggtgctggt cgaggccgag gccggtcttc gcggcctgga
    19801 acgattcctc gatcttccag cggcggccgg cgatcgcgac gagagtgccg agcgcgacga
    19861 cctcgggtga ccagcagcgg tagaaggcca gctcaccggt gcgacggctg cggcggatca
    19921 gcagccagtg gtgcccgctc tggtcatcga tggcgtgggg cagggcgatg aaggcccagt
    19981 cgtagtagcg gtggcctttt gcgccccggc cggcggaaat tcgctgccag gcggtgtcgg
    20041 gaagctcggc ggcgagggcg tcgacgcggt agacgccgag gccggtgatc acctgatgtg
    20101 agcaggccac ggccaggaca tagcccagtc gtagttgacg cagccgggcg gccagccgcg
    20161 ggtcgttgcc gtaggcctcg tcgccggccg cccaccggca cggcagccca gcggtgaccg
    20221 cggcggcgat catgcgggcc gccagctgtg gtttcgtcgc gaagcgcacc tgctcaggga
    20281 caccggcctc ggcacgtcgt tcggggtcgt cgcaccacga cttcggcagg tagagggccg
    20341 tgtcgagcat cgcgtgagca gcctcggtgg catagaccag gtgcacggcg agctggcagt
    20401 tctcgatctt cccggcggtg cccgaatact gccgctgcac cccgacggtg tgccgaccct
    20461 tcttcagatc acccgtctca tcgatgacca gcacggcctc accatcaccg agatgctcac
    20521 cgacgaactc gcggacatcg gcacgaacct cggcgtcgtc ccacgtcacc cgggtcagca
    20581 ggtcctgcat cccgtccggg ccggcgtccc cggcgtgttc ggcgatgctc cagcagttct
    20641 tccgcggtag cggcgccaac agcccccgaa cgaagtcaca cacccgccga cgcggctcgg
    20701 gcctgcggaa acgctgcccg accgtcaaca tcaggtcgtc gaacaacacc cgccaccgct
    20761 gggcgtctac cctgtatccg gcagccaccg ctgcatcatg gtcagtccac acaaccgccc
    20821 atgatcgacg gtggctgccc tcgtaccccc accgcaccga accgcagctc agccgaggtc
    20881 aacatccccg gctggagtac taggctcaac gcgtgggcgt gcggacgggc ccagcgcacc
    20941 agcgccttca gtgacgcggc cggcagccgc cgcaccacag cgaaggtggt cgcccgccgt
    21001 gccgcccaca acgcgcaccc ggtgcacacg aacacacccg gcgtcatgcc gagctcggcg
    21061 acctcgtcgg cggcgaaggt gttaccgcag cagccatatc gacgggtcgg atcgagccat
    21121 cggccggcgt catcacacga ccctcttcct caacgccctg gccaggtcgg ctacctcggg
    21181 caacccggcg aggctcccgg actctgtccg gaaaacccgg caggtcaacc ccgccggtac
    21241 cgcttcgttt ccgagcaggt cgaccccgtc gatcaggaac gtcggcgacc cggccaagcc
    21301 ggccgccgca gcctccggtt cgctgctgac caccacgaat tcgacattca ccgcggcctg
    21361 accgacagcg tccaacgcca cccgcaaccg ttgtccggcc gcccgtcaat tcgggcaatc
    21421 cgcgaaatac acaatcgacg ccctcacccg atctattctg ccccttcgga ccgctgaagc
    21481 agtggttcag ccccgcctcc ggcagcaggg aggggagggt cgtaccgcgc ggcgcacaag
    21541 atcgcctcgc cgtcgtcggc gaagggttca gcggggctgc acggcgtcct tgtcttccga
    21601 tgcattcgag gggtgcggcg cgggctcgtc cggcgtgctc actcgggtgg ccgggtcgtt
    21661 cgccgttcgt gggcctcgcc agaggtagag gacggcggcg aggaagatga tcagggaagt
    21721 ccagtcgtta aggcgcaggc cgaggatgtg gttggcgtgg tcgacgcgta gggcttcgat
    21781 ccaggcgcgg ccgacggtgt aggcggcgac gtagagggcg aacgcgcggc cgccgccgag
    21841 cttgaagcgg cgttcggccc agatcaccag gccggccacg ccgaggtccc acaggcattc
    21901 gtagaggaac gtcgggtggt agagggcgac ggtcggggtg tcggcgggtc ggtgagcagg
    21961 gtcgatgtgc agcgcccacg gcagggtggt ggcccggccg tagagttcct ggttgaagta
    22021 gttaccccac cggccgatgg cctgggcgac gaccaggcca ggtgcgaggg cgtcggcgta
    22081 ggcggtcagg gcgatgccgc ggcggcggca gccgatccag gcgccgagcg cgccgaaggc
    22141 caccgcgccc cagatgccga ggccgccgtc ccagatgtac agcgcctgga tggggtggtg
    22201 gccggcggtg aagtacagct ctgggtcggt gatgacgtgg tagagccggc cgccgatgat
    22261 gccgaacggg accgcccaga cggtcacgtc gaggacgtct tcggcgcggc cgccgcgggc
    22321 gacccaccgg cggcgggtga tcaggaccgc cacgatgatg ccggccagga tgcagaacgc
    22381 gtacgcgcgt acgggtaggg ggcccaggtg ccagactccc cgggagggac tgggcagata
    22441 ggtcaagatc atggtgtctc ccgccggcat gccggtgctc gccgcagtcg gcctcggcgc
    22501 cgggtcgagg tcacggtagg cccggccact ggccaggcat gctcgcttgg cacgttaccg
    22561 ccgggcgtgg ccgccgttgt ccacgggttg gtggtgccga agccgtgggg gcgttgggtg
    22621 cggcctgcgg ggcaggtcgg cgcgtgcggg cgcatcatgg ggtcatgacc tcttcgcacg
    22681 cggccggcac ggtcttttcg aaccaccccg ggcagggtgc ggccggttcc ggggccgcgt
    22741 tacggctgtc gggtgcggtc gtgccggtgg tcggtacggc tcgggtgtac acgtgtggga
    22801 tcaccccgta tgacgtgacg catctggggc acgcggcgac gttcgtgtgg tcggatctgc
    22861 tggcgtcggt gtggcggctg gccggggtgg agacgctcgg ttgccgcaac gtcactgatg
    22921 tcgatgatgt gctgacccgg gccgcgggtc tgcgcggcag tgacttcgac cagttcgcgt
    22981 tgcagcagga gtacctgttc gacaaggaca tgaccgcgtt gcgggtgcgg cgtccggcgc
    23041 acgagccgcg ggcgcggcat cacatcagcg cagtgcagca gctcgccggg gccctgctgg
    23101 ccggcgggcg ggcgtatctg cgggacgggt tcgtgtactt ccgtggggcg caggttgccg
    23161 cggcgtgcgg gttgtcgcgt gcggaggcgc tcgcgcggag ctcggagtac ggcgacgatc
    23221 cgcaggatcc gcgtcgtgac gacccgttcg acgtggcggt gtggcggccg tcgggtgagg
    23281 gccagccggc gtggccgagc ccgtgggggc cgggccgccc gggctggcac gcggagtgcg
    23341 cggcgatggc gctgtcggtg ttcgggccga gtgtggacgt gctggccggt ggggaggatc
    23401 tggtgttccc ccaccacgcg tatcaggcgg cgatggtcga ggcggtcacg tcggtggcac
    23461 cgttcgcgcg ggcgcggttg cacgtggggg cggtgcatca ggacggcacc aagatggcca
    23521 agtcgaccgg caacctgacc ctggtcgccg atctgttgcg tgatcattcc ccggcggcgg
    23581 tgcggatgct gctgctggac cggccgtggc ggtcggtgtg gcagtatcgt cccggtgatc
    23641 tcgacacggc ggcggcccgg ctcgagcagc tgtacgcggc ggccggccgc ccgggtggca
    23701 ccggtgaggc cgccatcggt gttgtcgttg cggccctgct cgacgacctc gacgtgcccc
    23761 aggcggtcga ggtggcggtg gacgccggcg gcgacgcggc gcggctactg ctgcgggtgc
    23821 tggccctggc gtgagcgacg cggccagggg cgcggcatga agcgcggggt ccgggccgcg
    23881 tacgccgggt agtcggggaa acggcgggtg agctgggttt cctcccagcg ggacttcgcg
    23941 gcgagcagcg cggccagagc cacggcggcg atggcccgag gcaggctgcc ggaggcgatg
    24001 atccacccgg cggcggccag gagcagtccg ctgtagacgg ggtggcgtac ccggcggtag
    24061 agcccggtgg tgcgcaggcg ggcagcgtcg ttgggtagcg gtgaggcggt caggccgcgg
    24121 ccgagtccgg ccgcggcggc tgcggcgagc accgccccgg caaccgtgac ggctgcgccg
    24181 gccagccgca ccggccatgg tacgggccag cccggtcggg ccggcgcgac agcgaccgcc
    24241 gcgatgagca gcagctgcgc ggcgacgaga ctccacgcga ttatctgcgg ccgggagccg
    24301 gcgccggagt gaggtgcggc atgcatgccg gcgggtcagg ccgtgatggc gggcagccgg
    24361 tcgatgatct cggccggggt gtgatcgcgg gggccgcggt tgtagggcag ggcggacagg
    24421 atgcggccca tggtgcaggt gtcgctcagg gcggagaagg tcagtccggc gccgataccc
    24481 gcggcgagcc agcgggcctt gggggcgcgt aggccggcgg ccagcccggc caggacgagg
    24541 ccgccggcga ccaggcgtac ctgacgttcc agcgaccagc gggccctgcc gcgaacgatg
    24601 tcgccgccgg tgacggcgta ctgctcgaca ccgccatcga ggacccgcag gccgccggcg
    24661 ccggctgcgg tgaggcggcg gcgggcttgc tcggcgcggg tgccggactg gcacatcagc
    24721 acgacatcgc cgtcgaggcg ggcggcgacc tgtggggcgt gactttcgat gacggtcagt
    24781 ggcacgttca cggcgccgtc gatgtgggtg gtctcgtact cggccggggt ccgcacgtcg
    24841 acgatgctca cctgcccgcc gccggtgagc cgctggaaca gggcggtgac gtcgaggcgg
    24901 tccggggccg aggtggtcac agagtttctc cttcgttcgg atgtccgggc ttgtcaggtg
    24961 agcagggtgt gtccggcggt gtaggcggcg acggcgagga tcagcacggc gaacgcccgg
    25021 gtggtgacag tttgtgggag ccggtcggcg atcttcttgc cggcgaggct ggcggccatc
    25081 gcggcgaggg tgaacgggat gatgatcgtc cagtcgaagt gggcgtggcc ggtgcgggcg
    25141 gccagcgacg cggcggagtt gatcgcgatg atcagcaggg aagtgccgac ggcgaccggc
    25201 atcggcaggt cgaggacgat gaccagggcg gggacgatga cgaagccgcc gccgacgccg
    25261 aggaagccgg tgaggaaccc gacgagcaga cccgcgatga cgaccttggc ggcggtgccg
    25321 gtgcgggagc gggcgggagc ggcggctcgg gtgagctggg cggtaccggt acggctcgtg
    25381 ctgccggtcg aggggtcggg ttcgtcgtcg tggggggcgg cgggttcgtg gcgggcgcgg
    25441 gcgagcatgc cgatcgcggc gagggtcatc agggcggcga agccgaggag caggatgtgt
    25501 ggctcgacgt gccggttggc ggcggttccg gccacggcgg cggcgatccc ggcgacaccg
    25561 aacgcgatgc cggtcggcca gcgcacgtgg cgggagcggg cgtgcccgac ggcgccgacg
    25621 acggcggtga gcccgacgat gatcaggctg ctggtggtgg cgtcctgtgg gttttgcccg
    25681 agcaggtaga ccagggcggg gacggtgagg atggcgccgc cgccgccgag cgcgcccagg
    25741 accgctccga tgagcagtcc caggccggcg gcggcgaaca ggatcacgcc actgtcccct
    25801 cgcggccgtc gtcggtgcgc acgggcagtc cggcctgggc ccaggcggtc atgccgccgg
    25861 tgaggttacg ggcgtccagg ccggcggcga gcagttttcc ggtcgcgatg gtggagcgtt
    25921 tcccggagcg gcagaccgcg atgacgggtc ggccggcggg cacgtcggcg gggttgaggg
    25981 agccgagggg caggtgcagg gcgtgcgggg cgtgcccggc ggcccattcg tcgggttcgc
    26041 ggacgtcgac gagggtgaca gcgccctcgc tgacgagttt ctcggcggtg gcagcgtcga
    26101 cgtcggtgac ttctggtgtg gtcatcgggg ctccgtgagg gtggcggcgt gcggacggcg
    26161 acgtggccgg ggtgcgggtc cggtgacgtc gaggcggtag ccggtgcggg cggtgaacgc
    26221 ggcggtgacg ctgaaccggt caccgcgtac gagggtggtg cgccattcca ggggccggcc
    26281 gtggtgctcg gagagtcgtt cgatggcgaa cgcggcgacg gtgtcgtcga tgccgagctg
    26341 ggtccgttcg gcgtgggtgg gtatcacggc gcg
//
