LOCUS       NZ_CP118233            21083 bp    DNA     circular CON 13-JUL-2024
DEFINITION  Micromonospora chalcea strain 1K05785M01 chromosome, complete
            genome.
ACCESSION   NZ_CP118233
VERSION     NZ_CP118233.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora chalcea
  ORGANISM  Micromonospora chalcea
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Study on the Growth Characteristics and Drug Resistance Related
            Proteins of Micromonospora chalcea MCCC 1K05785
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-FEB-2023) Tianjin University, Tianjin University,
            Weijinlu Nub92, Tianjin, Tianjin 300072, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2022
            Assembly Method                   :: CLC NGS Cell v. 5.29
            Assembly Name                     :: TJU-micro-1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028768405.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 23:01:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,224
            CDSs (total)                      :: 6,161
            Genes (coding)                    :: 6,110
            CDSs (with protein)               :: 6,110
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 16 of 51
            Pseudo Genes (incomplete)         :: 40 of 51
            Pseudo Genes (internal stop)      :: 2 of 51
            Pseudo Genes (multiple problems)  :: 7 of 51
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:37:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2969210
            Orig. end                         :: 2990293
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP118233.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21083
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="18"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11083
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    31..45
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(235..738)
                     /db_xref="GeneID:91357004"
                     /locus_tag="PVK74_RS12595"
                     /old_locus_tag="PVK74_12595"
     CDS             complement(235..738)
                     /codon_start=1
                     /db_xref="GeneID:91357004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785282.1"
                     /locus_tag="PVK74_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12595"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_043329447.1"
                     /transl_table=11
                     /translation="MPTSPAQAPTVPAHVLPHRTPAQLLAVARDGLAEAARTRPDGLRY
                     AAAHLAALRAAAAVLAARARPAPTRRNRITSVWVLLATVAPELDEWAAYFAAGASKRAA
                     AEAGIPRVVTAREADDLLRAAEEFVTVVETALGLAHQPALDGLPRPLRRGAPDSPTRPG
                     AAAA"
     misc_feature    complement(1101..1118)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(1118..1133)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.7"
                     /tool="antismash"
     misc_feature    1119..1132
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.82"
                     /tool="antismash"
     gene            1252..1740
                     /db_xref="GeneID:91357005"
                     /locus_tag="PVK74_RS12600"
                     /old_locus_tag="PVK74_12600"
     CDS             1252..1740
                     /codon_start=1
                     /db_xref="GeneID:91357005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742850.1"
                     /locus_tag="PVK74_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12600"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_064445214.1"
                     /transl_table=11
                     /translation="MQPHPNVQAVQRALDEAGARDGSGEASLVRLLPDAVHTAAAAAEA
                     LGVAVGAIANSLIFDADGAPLLVLTSGAHRVDTAGLAATLGVTRLRRATPEFVKQHTGQ
                     VIGGVAPVGHPTPLRTVVDTALTGYDEVWAAGGVPRAVFPTTYAELLRITAGAPAEVA"
     gene            1737..2465
                     /db_xref="GeneID:91357006"
                     /locus_tag="PVK74_RS12605"
                     /old_locus_tag="PVK74_12605"
     CDS             1737..2465
                     /codon_start=1
                     /db_xref="GeneID:91357006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287628.1"
                     /locus_tag="PVK74_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12605"
                     /product="monooxygenase"
                     /protein_id="WP_274479105.1"
                     /transl_table=11
                     /translation="MNPELVTLHVWRVPRRAVPGVPARMATHPARLRRLPGVRFAKLLG
                     TGTGTGFGPGDADLTRWAALVVWDSLADAAGFDASPVARSWARIARAAVRVDLRPLTSR
                     GRWSGREPFGAPSGGRVTGPVLALTRARLRARRAATFWRAIPPVATELHAAPGLLARFG
                     VGEAPLGWQGTVSVWRDPADLVAFAYRSPEHRAAITRTPTEGWYAEELFARFAVGDVVG
                     DRTVLGWAAEGGPETARGYA"
     gene            2462..3016
                     /db_xref="GeneID:91357007"
                     /locus_tag="PVK74_RS12610"
                     /old_locus_tag="PVK74_12610"
     CDS             2462..3016
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287629.1"
                     /locus_tag="PVK74_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12610"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_043329442.1"
                     /transl_table=11
                     /translation="MRLVRWTPDDLVRRLDDVVAVYGEAMGYRPDLLEARRGYIATHVR
                     RPGFRAVASLTTEGHLAGFGYGYRGATGQWWHDQVHRALNARDRQRWLAHPFEVVELHV
                     RPPAQGHGLGARQLRALLAVAEGDTTLLSTPEADEEKSRAWRLYRRFGFVDVLRHFHFP
                     GDERPFGVLGRDLPLPPPDAP"
     gene            3136..3939
                     /db_xref="GeneID:91357008"
                     /locus_tag="PVK74_RS12615"
                     /old_locus_tag="PVK74_12615"
     CDS             3136..3939
                     /codon_start=1
                     /db_xref="GeneID:91357008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785286.1"
                     /locus_tag="PVK74_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12615"
                     /product="carotenoid biosynthesis protein"
                     /protein_id="WP_113972534.1"
                     /transl_table=11
                     /translation="MRARLPWALLAALILAQICYPLTGGATRAGLTVATVVLGWLLSVG
                     HALLTRGVRTAAALVAVVTGGGFAVEAIGVATGFPFGTYDYSGELGPKLAGVPLIIPLA
                     WTWMAWPAWLTAVRLVRSRLARIALSAVGLAAWDLFLDPQMVAEGYWTWRDATPALPGL
                     PGIPVSNYLGWLGFAVLLAVALRPLAGPSVDRTDGRDAPMFALYLWTYASSVLAHAVFL
                     RLPASALWGAAGMAVAAVPLAVTLWRARRDRAAAPEPAPRVDAPA"
     gene            3936..5063
                     /db_xref="GeneID:91357009"
                     /locus_tag="PVK74_RS12620"
                     /old_locus_tag="PVK74_12620"
     CDS             3936..5063
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /db_xref="GeneID:91357009"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018736171.1"
                     /locus_tag="PVK74_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12620"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_274479106.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.9e-13,
                     bitscore: 49.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIATLALAVAVAALTGHTIVNAYAWLRRPAAGPAEVTEPVAVLLP
                     LRDEADRVTPCLRALLAQRGVPDLRIVVLDDGSTDGTADVVRAVAGDDPRLTLLTGVAP
                     PPGWLGKPHACWQLATRTAPEPAVLAFVDADVVLTPYAVAAAVTELRAADAALLSPYPR
                     IVVRTVADRLAQPLLQWLWLTFLPLRAMERSRRPSLAAAGGQFLVVDRAGYLRAGGHAA
                     VADKVLEDIELARAVKRAGGRIALADGSRLASCRMYDTWPQLRDGYTKSLWATFGHPAA
                     AAAVLALLFALYVAPPLLALGALLAGAPAVAAVAFLAYLAGVAGRVVSARATGGRAWPD
                     ALAHPVSVVVLGWLTVRSYHLRKRHRLTWRGRPVT"
     gene            5076..6563
                     /db_xref="GeneID:91357010"
                     /gene="crtI"
                     /locus_tag="PVK74_RS12625"
                     /old_locus_tag="PVK74_12625"
     CDS             5076..6563
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357010"
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014459.1"
                     /locus_tag="PVK74_RS12625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12625"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_064445212.1"
                     /sec_met_domain="DAO (E-value: 5.5e-10, bitscore: 37.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARIVVIGAGVGGLAAAARLAVTGHEVTVLERAGTVGGKLGRYAH
                     HTPEGVWHFDTGPSLFTLPQVFHDLFEATGAKLDEYLDLVPLDPIVRHVFPGGGQALDS
                     CADPDEFAARIGAAFGDRSAADWRGLWRRAGRVWAASHRDILRRTVDSPRDLAALAWRL
                     GDLAAIGPGRSLRGLGRRHLSDPRMRMLLDRYATYTGADPRRAPAALVAVPYAELAYGG
                     WYLRGGLGTLADALLSRCLDLGVVVRTDAAVTRIDAAGGRVHGVRVAGSAAPVPADVVV
                     ANVDALTVYRDLLPDPRRLAALTDRSLAGFVLLLGVRGDSGLAHHTVFFPRDYDAEFDA
                     VFGDPGRGVRARPAPDPTVFVTAADDPAVRPDGHEAWFVLVNAPRHGTAASAVDWRRPG
                     LAEAYADRILDVLAERGADVRDRLVFREIRTPADLDAATGAPGGAIYGTAGGLLRPANR
                     GPAAGLWLVGGSSHPGGGLPMVTMSAEIVAEAVGPAW"
     gene            complement(6693..7382)
                     /db_xref="GeneID:91357011"
                     /locus_tag="PVK74_RS12630"
                     /old_locus_tag="PVK74_12630"
     CDS             complement(6693..7382)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287633.1"
                     /locus_tag="PVK74_RS12630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12630"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_064445211.1"
                     /transl_table=11
                     /translation="MVGTQLNWDQYATAWARLHGGFDPRTAAPVVRAWLRFAYHVGYVL
                     GRLRVGPTPVTVFGVLLCFCVPLFAERPGDGPFLGALFVLLAAVADSVDGAVAVATGRT
                     TRLGYVYDSVADRLGEVAWLIAFWLLGAPGALVAAAGGLSWLHEYVRARAVSAGMREIG
                     AVTVGERPTRVSVALVGLLVAGLTGLIDADLTAGTITMATTVWVLLAGFGLGQLLSAVR
                     RALVDAG"
     gene            complement(7427..8344)
                     /db_xref="GeneID:91357012"
                     /gene="metF"
                     /locus_tag="PVK74_RS12635"
                     /old_locus_tag="PVK74_12635"
     CDS             complement(7427..8344)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357012"
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785290.1"
                     /locus_tag="PVK74_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12635"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_064445210.1"
                     /transl_table=11
                     /translation="MALGLPSVLPNPQPAIGELIRDGRPTFSFEFFPPKTQAGEKLLWQ
                     AIRELESLRPSFVSITYGAGGSTRDTTVAVTERIATETTLLPMAHLTAVNHSVAELRHV
                     IGRLASVGVRNVLAVRGDPPGDPGGEWIAHPEGVRYAEDLVRLVRDSGDFSVGVAAFPY
                     KHPRSPDVDSDTAYFVRKCRAGAEFAITQMFFDADDYLRLRDRVAATGCDTPILAGVMP
                     VTQIGTIERSVQLSGAPFPPALAERFERVADDPEAVRRLGVEQASEMCEKLLDEGVPGI
                     HFITLNRSTATREVWQRLRAAARV"
     gene            8564..9991
                     /db_xref="GeneID:91357013"
                     /locus_tag="PVK74_RS12640"
                     /old_locus_tag="PVK74_12640"
     CDS             8564..9991
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287635.1"
                     /locus_tag="PVK74_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12640"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_069089013.1"
                     /transl_table=11
                     /translation="MIPSWPPGPRLLGPLLAELRAARGWSQQRLAAELCAASGVPTLTR
                     HEVSRWERQLRLPGDFWSAWLATVLGVPGELLAGAAASSRRLGVTPVAVDPAGSRARLA
                     LLTLAHRWAADPGGGTLAGPFTGPATPPVPGPATGDGYGPARAADRAGPVRGHPADGAS
                     LATLRRWDDLLGGGDLAGLGARRLRRSVRGYRRAGPAGRRRMLPSLAESAQLAGWLAAD
                     AGDLTGGLVAYRLALRAAVAAGEPPLAGHVLGSASHLLSDAGDAAGALVLARIGYAASR
                     ATASPGLRALLLHRVALAAALGGRRRAAGEALAGADRAGPPEPGREPQWLYWLDAAELA
                     AMTGRTLVALGRAAAAVPLLTPVVTAPGRPRRSAVYGGWLARAHLGLGAEPEACAVAGE
                     ALLDAVRSGSPRAVGQLTEFRRGLARRPPGPATRGYARLLAATRPYLPSRHPWRPSPPV
                     SCEARRDGGTTGAGPNR"
     gene            10001..11083
                     /db_xref="GeneID:91357014"
                     /locus_tag="PVK74_RS12645"
                     /old_locus_tag="PVK74_12645"
     CDS             10001..11083
                     /codon_start=1
                     /db_xref="GeneID:91357014"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215763.1"
                     /locus_tag="PVK74_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12645"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_043329435.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.1e-49, bitscore:
                     164.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHAAPVSPVDRAGLRQRIDKALTEFLAGQRGWLTAVDDGLLPVA
                     EAIEAFVLGGGKRLRPAFGYWGYRGAGGVDSDQVVAALAALEFVQASALIHDDLMDRSD
                     TRRGEPAVHRRFAARHRAAGWGGDADAFGDSAAILLGDLCLVWSDELLHSSGLPPATVA
                     RARPVFDEMRTEVTVGQYLDVLTQATADTSLDRAAKVARYKSAKYTVERPLLLGAALAG
                     APPEVHAAYSAYGLPLGEAFQLRDDVLGVFGDPELTGKPAGDDLREGKRTYLVAAALET
                     LDEAGREALLAGLGVPDLDAAGVDRLRELITSSGALERAERHITALTESALAALTAVDL
                     DTEARQALVDLAIAATRRPA"
     gene            complement(11216..11596)
                     /db_xref="GeneID:91357015"
                     /locus_tag="PVK74_RS12650"
                     /old_locus_tag="PVK74_12650"
     CDS             complement(11216..11596)
                     /codon_start=1
                     /db_xref="GeneID:91357015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016816979.1"
                     /locus_tag="PVK74_RS12650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12650"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_043329433.1"
                     /transl_table=11
                     /translation="MTDSVPAETGADLAGPADPAGWLTLPDVAERLDLSISKVHQMIRD
                     RELLAVRRDGVRRVPADLVANRTVLKHLPGVLNLLADAGYDDEEALRWLYREDPSLPGT
                     PAVALGGDLAREVKRRAQAVAF"
     gene            11739..13724
                     /db_xref="GeneID:91357016"
                     /gene="pknB"
                     /locus_tag="PVK74_RS12655"
                     /old_locus_tag="PVK74_12655"
     CDS             11739..13724
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357016"
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018907613.1"
                     /locus_tag="PVK74_RS12655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12655"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_064445208.1"
                     /sec_met_domain="Pkinase (E-value: 3.2e-50, bitscore:
                     169.4, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 9.2e-06, bitscore: 24.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTQVADTLLGSLIEGRYRIRGRVARGGMATVYTATDERLERTVA
                     VKIIHPTQAPQARARMAGFVERFTDEAKTIARLTHPNVVAVYDQGIHAGLPYLVMEYVR
                     GRTLRDVLAERRRLNPDEALAITEQVLAALAAAHRAGLVHRDVKPENVLVAEVPAGGSR
                     DLVDSVVKVADFGLARAVEASAEDENGNQLMATVAYVAPELVTQGHADPRTDVYSAGIV
                     LFEMLTGRVPYDGDRPVEVAWQHVDRDVPAPSTLVPALPPAVDALVARATRRDPAARPA
                     DAAALLTEVQAAREELGNPHTHTTVLRQLSDDTAVLSQPTQVVAALQPIERPSWARLPE
                     GAATQRPHRRRAAEPEGVGARFAALRTRIMGSPRGRLAVAAAVVVLGLVAAVGGWWFGV
                     GRYTVAPQMVSLTKAEAEAQAQRGGFTLRYADPRYDENVPKDTVLGQAPGSAARIVKGG
                     TITLTLSLGPERLPVPDVVGKDFALAQVELEGLNLVAAKGSSRYDDALPAGVVLATDPK
                     VGTEVKPGAKVTLILSKGRAPVSVPDLVGKSLTEARAILARLGLKPVENVKESDKPKDE
                     ILGQSPADGTGVEKGAQVKLEISKGPPQVAVPRVVDMPCQQAKQTLESQGFPVNIQLNP
                     NGIVRIQNPAENTPVPPGTTITVTCL"
     gene            13721..14590
                     /db_xref="GeneID:91357017"
                     /locus_tag="PVK74_RS12660"
                     /old_locus_tag="PVK74_12660"
     CDS             13721..14590
                     /codon_start=1
                     /db_xref="GeneID:91357017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287639.1"
                     /locus_tag="PVK74_RS12660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12660"
                     /product="deoxyribonuclease IV"
                     /protein_id="WP_187693126.1"
                     /transl_table=11
                     /translation="MSAANGCRPVGSHTPTSGGLARAALPYADAAESEVVQVYVSNSRG
                     WALPAGDPAQDALFRDGCAERGLPVFIHASLLVNLGSPTPATVTRSAETLAHALRRGRA
                     IGAEGVVFHAGSSVDAGHAEAALRQVRESLLPLLDETAATGGPMLLVEPSAGGGRSLAS
                     RVEHLGPYLDAVDRHPMLGVCFDTCHAWAAGHDLAAEGGMTATLDTLVATVGADRLRLV
                     HANDSKDLCGSTRDRHENIGKGTIGEPAFAELMRHPAAAGVPVLVETPTEKHVGHAADI
                     AALKRLRP"
     gene            complement(14634..15653)
                     /db_xref="GeneID:91357018"
                     /locus_tag="PVK74_RS12665"
                     /old_locus_tag="PVK74_12665"
     CDS             complement(14634..15653)
                     /NRPS_PKS="Domain: Beta_elim_lyase (2-278). E-value: 1e-83.
                     Score: 272.9. Matches aSDomain:
                     nrpspksdomains_PVK74_RS12665_Beta_elim_lyase.1"
                     /codon_start=1
                     /db_xref="GeneID:91357018"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287640.1"
                     /locus_tag="PVK74_RS12665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12665"
                     /product="GntG family PLP-dependent aldolase"
                     /protein_id="WP_104114584.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 5.2e-05,
                     bitscore: 21.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.4e-05, bitscore:
                     22.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDLRTDTVTRPTPGMREAMAAAEVGDDVYGEDPTVAALEAEVAA
                     LFGHEAALFAPSGSMANQIALQLHVPPGDELLCDADAHVVTYEVGAAAAYGGISSRTWP
                     AVGADLDPDVVAGMIRPDGYFAVPTRAIAVEQTHNRGGGGVIPLPTLRRMREVADEHGV
                     ALHCDGARIWHAHVADRVPLAGYGELFDTLSVCLSKGLGAPVGSLVVGSAEKIARARVL
                     RKRMGGGMRQVGILAAAGRYALAHHVERLAEDHAKAARLAEAVAPHGVLASVVRTNIVP
                     LDLTKHPLDAHALAAAAREAGLLISVLGPRTARLVTHLDVTDEQIDSAATILDTALRA"
     aSDomain        complement(14820..15647)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PVK74_RS12665_Beta_elim_lyase.1"
                     /evalue="1.00E-83"
                     /label="PVK74_RS12665_Beta_elim_lyase.1"
                     /locus_tag="PVK74_RS12665"
                     /protein_end="278"
                     /protein_start="2"
                     /score="272.9"
                     /tool="antismash"
                     /translation="DLRTDTVTRPTPGMREAMAAAEVGDDVYGEDPTVAALEAEVAALF
                     GHEAALFAPSGSMANQIALQLHVPPGDELLCDADAHVVTYEVGAAAAYGGISSRTWPAV
                     GADLDPDVVAGMIRPDGYFAVPTRAIAVEQTHNRGGGGVIPLPTLRRMREVADEHGVAL
                     HCDGARIWHAHVADRVPLAGYGELFDTLSVCLSKGLGAPVGSLVVGSAEKIARARVLRK
                     RMGGGMRQVGILAAAGRYALAHHVERLAEDHAKAARLAEAVAPHGVLASVVRTN"
     gene            complement(15713..17119)
                     /db_xref="GeneID:91357019"
                     /locus_tag="PVK74_RS12670"
                     /old_locus_tag="PVK74_12670"
     CDS             complement(15713..17119)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475760.1"
                     /locus_tag="PVK74_RS12670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12670"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_064445207.1"
                     /transl_table=11
                     /translation="MRHEWHQLSHPAVGSPGLQTSRPTADSAEDAALGLDRWRELPRAQ
                     TPPWDDPAQVAEVCRVLDTVPSVVAPYEVDQLRQRLALVCEGKAFLLQGGDCAETFADN
                     TESHLLANARTLLQMAIVLTYGASLPVVKVARVAGQYTKPRSLPTDARGLPAYRGDMIN
                     SLEATPEARVADPQRMIRAYANSAAAMNMLRAYLAGGLADLHAVHDWNKDFVRQSPAGE
                     RYDAIAREIDRALALIRACGMTDDEALRTVTLYCSHEALALEYDRALTRISDHKAYGLS
                     GHFLWIGERTRQIDGAHIDFISRIANPIGVKLGPTTTPDEAIELCEKLNPDNIPGRLTL
                     ISRMGNHRVRDALPPIVAKVTAAGAKVVWQCDPMHGNTHESSNGYKTRHFDRIVDEVLG
                     YFEVHRGLDTHPGGLHVELTGEDVTECLGGAQGIEDLDLPDRYETACDPRLNTQQSLEL
                     AFLVAEMLRG"
     gene            complement(17177..17692)
                     /db_xref="GeneID:91357020"
                     /locus_tag="PVK74_RS12675"
                     /old_locus_tag="PVK74_12675"
     CDS             complement(17177..17692)
                     /codon_start=1
                     /db_xref="GeneID:91357020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287642.1"
                     /locus_tag="PVK74_RS12675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12675"
                     /product="hypothetical protein"
                     /protein_id="WP_166457808.1"
                     /transl_table=11
                     /translation="MDRSHRGRFAALALAFALTPALAACGSGPDGAATAPSGRAPAEEA
                     AAKSRERVQAYLDALTARDADAGRSQLCAPMHAAFDAAATGPNGDFADHFTVPEATITD
                     VRSGPNGQEVSASVTVAAGSRKATRSLLFTVTRNGADWCISGEVPGDRTADPSEPPPAA
                     RPSPVSSQ"
     gene            complement(17866..19500)
                     /db_xref="GeneID:91357021"
                     /locus_tag="PVK74_RS12680"
                     /old_locus_tag="PVK74_12680"
     CDS             complement(17866..19500)
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018807938.1"
                     /locus_tag="PVK74_RS12680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12680"
                     /product="glycosyl hydrolase family 18 protein"
                     /protein_id="WP_187693125.1"
                     /transl_table=11
                     /translation="MKRSLRRALWATGAVVALAVAAVPMTTASAAGSVTATFAKVQDWG
                     TGHEGRVTVTNGTSSTVNGWRIEFTLPSGTSISSSWDADITRSGDRYVAVNKSWASTLA
                     PGASFSWGYNGTGGYKAPVSCTINGGTCTGGGTPTTTAPTTAPPTTAPPTTAPPTTAPP
                     TTQPPTTPPPGGKKVVGYFAEWGVYARNYHVKNIHTSGSAAKLTHILYAFGNTTGGRCS
                     IGDSYADYEKAYTAADSVDGVADTWDQPLRGSFNQLRKLKKMYPNLKVLWSFGGWTWSG
                     GFTQAAQNPAAFADSCYSLVKDPRWADVFDGIDVDWEYPNACGLQCDSSGPNAFKNVVS
                     ALRSKFGSSFLVTAAITADGSNGGKIDATDYAGAATNLNWLMPMTYDYFGAFNAQGPTA
                     PHSPLYSYSGIPQQGFWSDAAIQKLKSKGVPSSKLLLGVGFYGRGWTGVTQAAPGGSAT
                     GAAPGTYEAGIEDYKVLKNSCPATGTVGGTAYAKCGSNWWSYDTPATIGGKMSYANSQG
                     LGGAFFWELSGDTSNGELIGAIKGGLG"
     misc_feature    complement(19514..19528)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.09"
                     /tool="antismash"
     misc_feature    complement(19528..19542)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.66"
                     /tool="antismash"
     gene            19644..20132
                     /db_xref="GeneID:91357022"
                     /locus_tag="PVK74_RS12685"
                     /old_locus_tag="PVK74_12685"
     CDS             19644..20132
                     /codon_start=1
                     /db_xref="GeneID:91357022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475757.1"
                     /locus_tag="PVK74_RS12685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12685"
                     /product="glutathione peroxidase"
                     /protein_id="WP_274479107.1"
                     /transl_table=11
                     /translation="MTVFDVQIDALTGGPADLGRYRGRALLVVNVASRCGLTPQYAGLQ
                     ELADTYAGRGLTVLGVPCNQFAGQEPGSAAEIEEFCQVNYGVTFPLTEKVDVNGPDRHP
                     LYAELVSTPDAEGHTGDVRWNFEKFLVAPDGTVAARFAPQVTPEDPELRAAIEKVLPA"
     gene            complement(20205..21008)
                     /db_xref="GeneID:91357023"
                     /locus_tag="PVK74_RS12690"
                     /old_locus_tag="PVK74_12690"
     CDS             complement(20205..21008)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91357023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287645.1"
                     /locus_tag="PVK74_RS12690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_12690"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_043329427.1"
                     /transl_table=11
                     /translation="MRRSRLATLALTLAASVGVTLSLAAPAQAAPSDRYVALGDSYASG
                     VGADSYTSESGNCLRSTNAYPALYNANIKPASYRSVACSGATTADVINSQLSALSSTTT
                     LVSVTVGGNDVGFANIMSTCVLQGETQCVAAVQSAMNVARTSMPGRLANVYNGIKSRSP
                     SARVVVVGYPVFYQLGTTCVGLSATSRAKINEGINLLDDITRTAAVSAGFKFADVRSIF
                     VGHQLCSGGTKWLHALNVLSLSKSYHPTAAGQSGGYYPVFRSAAG"
     misc_feature    21049..21062
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.4"
                     /tool="antismash"
     misc_feature    21049..21065
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.05"
                     /tool="antismash"
ORIGIN
        1 cgccggccgg gtcgggcgcg ctcgccggac ggaccagctc ggccagggcg gcggaaccga
       61 ccaccatgcg gcccgccatc ggaccaaccc cccgtcgtgt ttccgccacg ggcccgcccg
      121 tggatggtgc tgtggatcgt gtgctgtgga tcgtgtcggt gctgcggcac gtggtgccgt
      181 tggtgcggcg cccggccacc cggggtcccg ccggtggtgg ccgggcgcca cgaatcaggc
      241 cgcggctgct ccgggccggg tcggggagtc gggggcgccg cgccgcaggg gccggggcag
      301 gccgtcgagc gccggctggt gggccaggcc gagcgcggtc tccaccactg tcacgaactc
      361 ctcggcggca cgcagcaggt cgtcggcctc ccgggcggtg accacccggg ggatgcctgc
      421 ttcggcggcg gcccgcttgc tcgcgccggc ggcgaagtag gcggcccact cgtccagctc
      481 gggggcgacg gtggcgagca gcacccagac gctggtgatc cggttccgcc gggtgggcgc
      541 gggacgggcc cgggcggcga gcacggcggc ggcggcgcgc agcgccgcga ggtgggcggc
      601 ggcgtaccgg agaccgtcgg gacgggtgcg ggcggcctcg gccagcccgt cgcgggccac
      661 cgcgagcaac tgggcggggg tgcggtgcgg cagcacgtgc gcgggcaccg tgggcgcctg
      721 ggccggactg gtcggcatgg gtctctcctc cgcgtgtggc cggggcgggc ggtcgcgcga
      781 cggggaaacc gtcgcccggt cgcccggagc ggtcggtgcg gaggaagacg caccttcagg
      841 tggctggccg gccgggtgtg gacgcttccc cacacccacc cccggccggc gtgccggcgg
      901 gtccgtcgcc cgccgcccgg gggtcgtggg cggcgggcga cgacctgcct gacgggcccg
      961 gactcgcgac tgtccgaacc cggtgcggcc cgcggtgccg cacctcccgg aagccggtgc
     1021 cgcgaaacac cgcttccgga gcgttcgacg ggtgcccgac cggtcggacc ggagccgggc
     1081 cagccgggga gctgagccgc tatccgctct aaccgaatcg aacactcgtt ctaactaccc
     1141 tgacagtaca cctccctacc gacgaaaacg caacgtgtga cgcgccgggg acacacggga
     1201 gggccacggc ccccggcggg gccggaccgg gggtgaggga agaatggggg catgcagcca
     1261 cacccgaacg tgcaggcggt gcagcgcgcg ctcgacgagg cgggcgcgcg ggacggatcg
     1321 ggcgaggcca gcctcgtccg actgctgccc gacgcggtgc acaccgccgc cgccgcggcc
     1381 gaggcgctcg gcgtcgccgt cggcgccatc gccaactcgc tgatcttcga cgcggacggc
     1441 gcgccgctgc tggtgctcac ctccggcgcg caccgggtgg acaccgccgg gctggccgcc
     1501 acgctgggcg tgacccggct gcgccgggcc accccggagt tcgtcaagca gcacaccggg
     1561 caggtgatcg gcggcgtcgc cccggtcggc caccccacgc cgctgcgcac cgtcgtcgac
     1621 accgccctga ccgggtacga cgaggtgtgg gccgccggcg gcgtaccccg ggcggtgttc
     1681 cccaccacgt acgcggaact gctgcggatc accgccggcg cgccggccga ggtggcgtga
     1741 accccgaact cgtcacgctg cacgtgtggc gtgtgccccg acgggccgta cccggtgtgc
     1801 cggcccggat ggccacccac ccggcgcggc tgcgccgcct gcccggcgtc cgcttcgcca
     1861 agctgctcgg caccgggacc ggcaccggat tcggccccgg cgacgccgac ctgacccggt
     1921 gggccgcgct cgtggtctgg gactccctcg ccgacgcggc cggcttcgac gcctccccgg
     1981 tcgcccgctc ctgggcccgg atcgcccgcg ccgcggtacg ggtcgacctg cgcccgctga
     2041 ccagccgcgg ccggtggtcc ggccgggagc cgttcggcgc gccgtcgggc gggcgggtca
     2101 ccggtccggt gctggcgctg acccgggccc ggctgcgggc ccgccgggcg gccacgttct
     2161 ggcgggcgat cccgccggtc gccaccgagc tgcacgccgc gcccggcctg ctcgcccgct
     2221 tcggcgtcgg cgaggcgccg ctgggctggc agggcacggt gagcgtgtgg cgcgacccgg
     2281 cggacctggt cgcgttcgcg taccgttccc ccgagcaccg cgccgcgatc acccgcaccc
     2341 ccaccgaggg ctggtacgcg gaggaactgt tcgcgcggtt cgcggtgggc gacgtggtcg
     2401 gcgaccgcac ggtgctcggc tgggccgccg agggcggccc ggaaacagcg agagggtacg
     2461 catgaggctg gtgcggtgga caccggacga cctggtccgg cggctggacg acgtggtggc
     2521 cgtctacggc gaggcgatgg gctaccggcc cgacctgctg gaggcccgcc gcggctacat
     2581 cgccacccac gtacgccggc ccggcttccg cgccgtcgcc agcctcacca ccgagggcca
     2641 cctggccggc ttcgggtacg gctaccgggg cgccaccggg cagtggtggc acgaccaggt
     2701 gcaccgggcg ctgaacgcgc gggaccggca gcgctggctg gcgcacccgt tcgaggtggt
     2761 cgagctgcac gtccgcccgc ccgcgcaggg gcacggcctg ggcgcccgcc agttgcgcgc
     2821 gctgctcgcc gtggccgagg gcgacaccac gctgctgtcc acgccggagg ccgacgagga
     2881 gaagtcccgg gcctggcggc tgtaccgccg gttcggtttc gtcgacgtcc tgcggcactt
     2941 ccacttcccc ggcgacgagc ggccgttcgg cgtgctcggc cgggacctgc cgctgccccc
     3001 gccggacgcc ccgtgagcgc gaggagtgag ccgggtttgc gagccccgca gtcgcgaacg
     3061 aaagggcggc accgtgagcg cgaggagtga gccgggtttg cgagccccgc agtcgcgaac
     3121 gaaaggcggc acagcatgag agcccggctg ccctgggcgc tgctggccgc gctgatcctc
     3181 gcccagatct gctacccgct caccggcggc gcgacccggg ccgggctcac ggtggccaca
     3241 gtggtgctcg gctggctgct ctcggtcggc cacgcgctgc tcacccgcgg cgtccgtacc
     3301 gccgccgcgc tggtcgcggt cgtcaccggc ggcgggttcg cggtggaggc gatcggcgtg
     3361 gccaccgggt tcccgttcgg cacctacgac tactccggcg agctgggccc gaagctggcc
     3421 ggggtgccgc tgatcatccc actcgcctgg acctggatgg cctggccggc gtggctcacc
     3481 gcggtgcggc tggtccgctc ccgcctcgcc cggatcgcgc tgtcggcggt cggactggcc
     3541 gcgtgggacc tgttcctcga cccgcagatg gtggccgagg gctactggac ctggcgtgac
     3601 gccaccccgg cgctacccgg gctgcccggc atcccggtca gcaactacct gggctggctg
     3661 ggcttcgcgg tgctgctcgc ggtcgcgctg cgcccgctcg ccggtccgtc ggtggaccgg
     3721 accgacggcc gggacgcgcc gatgttcgcg ctctacctct ggacgtacgc ctccagcgtg
     3781 ctggcgcacg cggtgttcct gcggctgccg gcgtcggcgc tgtggggcgc ggccgggatg
     3841 gcggtggcgg cggtgccgct ggcggtgacg ctgtggcggg cccgccggga ccgggccgcc
     3901 gcgccggagc cggcgccgcg cgtcgacgcc ccggcatgat cgccaccctc gcgctggccg
     3961 tggcggtcgc cgcgctcacc gggcacacga tcgtcaacgc gtacgcctgg ctgcgccgcc
     4021 cggccgccgg cccggccgag gtgaccgagc cggtggcggt gctgctgccg ctgcgcgacg
     4081 aggccgaccg ggtcaccccg tgcctgcgcg cgctgctggc ccagcgcggc gtgccggacc
     4141 tgcggatcgt ggtgctcgac gacggctcga ccgacggcac cgccgacgtg gtccgcgcgg
     4201 tggccggtga cgatccccgg ctcacgctgc tcaccggcgt cgccccgccg ccgggctggc
     4261 tgggcaagcc gcacgcctgc tggcagctcg ccacccggac cgccccggag ccggcggtgc
     4321 tggccttcgt cgacgcggac gtggtgctca ccccgtacgc ggtggcggcg gcggtgaccg
     4381 agttgcgcgc ggcggacgcg gcgctgctgt cgccgtaccc ccggatcgtg gtgcggacgg
     4441 tggccgaccg gctggcgcag ccgctgctgc agtggttgtg gctgacgttc ctgccgctgc
     4501 gcgcgatgga acgctcgcgg cggccgtccc tcgcggcggc gggcgggcag ttcctggtcg
     4561 tggaccgggc cggctacctg cgggccggcg ggcacgcggc ggtggccgac aaggtgctgg
     4621 aggacatcga gctggcccgg gcggtgaaac gggccggcgg gcggatcgcg ctggccgacg
     4681 ggtcccggct ggcgtcctgc cggatgtacg acacctggcc gcagctgcgc gacggctaca
     4741 ccaagtcgct gtgggcgacg ttcgggcacc cggccgccgc ggcggccgtg ctggcgctgc
     4801 tgttcgcgct ctacgtcgcg ccgccgctgc tggcgctcgg ggcgctgctc gccggcgcgc
     4861 cggcggtggc cgccgtggcg ttcctggcct acctggccgg ggtcgccggg cgggtggtca
     4921 gcgcccgcgc caccggcgga cgggcgtggc ccgacgcgct cgcacacccc gtgtcggtcg
     4981 tggtcctcgg ttggctgacc gtccggtcgt accatctgcg gaagcgacac cggctcacct
     5041 ggcggggtcg cccggtcacc taggaggggc acgccatggc gcgcatcgtg gtcatcggcg
     5101 ccggggtggg cgggctcgcc gccgccgccc ggctcgcggt caccgggcac gaggtcaccg
     5161 tcctcgaacg ggccggcacg gtcgggggca agctcggccg gtacgcccac cacaccccgg
     5221 agggggtgtg gcacttcgac accgggccga gcctgttcac gctgccgcag gtcttccacg
     5281 acctgttcga ggcgaccggc gcgaagctcg acgaatacct ggacctggtc ccgctggacc
     5341 cgatcgtgcg gcacgtcttc cccggcggcg gacaggcgct cgactcctgc gccgacccgg
     5401 acgagttcgc cgcccggatc ggcgccgcgt tcggcgaccg gtccgccgcc gactggcgcg
     5461 ggctgtggcg gcgcgccggc cgggtgtggg cggcctcgca ccgggacatc ctgcgccgta
     5521 ccgtcgactc gccccgcgac ctggccgcgc tggcctggcg gctgggcgac ctggccgcca
     5581 tcggccccgg ccgcagcctg cgcgggctgg gccgccgcca cctgtccgac ccacggatgc
     5641 ggatgctgct ggaccggtac gccacgtaca ccggcgccga cccgcgccgc gccccggccg
     5701 cgctcgtcgc cgttccctac gccgagctgg cgtacggcgg ctggtacctg cgcggcgggc
     5761 tgggcacgct cgccgacgcg ctgctgtcgc gctgcctgga cctgggcgtg gtggtacgca
     5821 ccgacgccgc ggtcacccgg atcgacgccg cgggcgggcg ggtgcacggg gtacgcgtgg
     5881 ccgggtcggc cgcgccggtg cccgccgacg tggtggtcgc gaacgtggac gcgctcaccg
     5941 tctaccggga cctgctgccc gacccgcgcc ggctggccgc gctcaccgac cgcagcctgg
     6001 ccggattcgt gctgctgctg ggcgtgcgcg gcgactccgg gctggcccac cacaccgtgt
     6061 tcttcccccg cgactacgac gccgagttcg acgccgtgtt cggcgacccg ggtcgcgggg
     6121 tgcgggcccg cccggcgccc gacccgaccg tgttcgtcac cgccgccgac gatccggcgg
     6181 tccgccccga cggccacgag gcgtggttcg tgctcgtgaa cgcgccccgg cacggcaccg
     6241 ccgcgagcgc cgtggactgg cggcggcccg gcctggccga ggcgtacgcg gaccggatcc
     6301 tcgacgtgct ggccgagcgc ggcgccgacg tgcgggaccg gctggtgttc cgggagatcc
     6361 gtaccccggc cgacctggac gcggccaccg gcgcgccggg cggggcgatc tacggcaccg
     6421 cgggcgggct gctgcgcccg gcaaaccggg gcccggcggc cgggctctgg ctggtcggcg
     6481 gctccagcca cccgggcggc ggcctgccca tggtcacgat gtccgccgag atcgtcgccg
     6541 aggcggtcgg ccccgcctgg tgaggggtgt aaggaagggc cccctattaa cgcctccggt
     6601 agaggaaggg ccccttatta acgcgcgccg cccgccgccc gccgcgcgcc tcgcgtgggc
     6661 gcggcggggc tgcgcgggcg cgggcgcggc ggtcagcccg cgtctaccag ggcgcggcgg
     6721 acggcggaga gcaactgccc caggccgaac ccggcgagca gcacccacac cgtggtggcc
     6781 atggtgatgg tgccggccgt caggtcggcg tcgatcagcc cggtgagccc ggcgacgagc
     6841 agcccgacca gcgccacgct gacccgggtg ggccgctccc ccaccgtcac cgcgccgatc
     6901 tcccgcatcc ccgccgacac cgcgcgcgcc cgcacgtact cgtgcagcca ggacaggccc
     6961 ccggccgccg cgaccagcgc gccgggcgcg ccgagcagcc agaacgcgat cagccaggcc
     7021 acctcgccga gccggtcggc gaccgagtcg tagacgtagc ccagccgggt ggtgcggccg
     7081 gtcgcgaccg ccaccgcgcc gtcgacgctg tcggccaccg ccgccagcag cacgaacagc
     7141 gcgccgagga acggtccgtc gccgggccgc tccgcgaaca ggggtacgca gaagcagagc
     7201 agcaccccga acacggtcac cggggtgggg ccgacgcgca gccggcccag cacgtagccc
     7261 acgtggtagg cgaagcgcag ccaggcacgc accaccggcg cggcggtacg cggatcgaat
     7321 ccgccgtgca gccgcgccca cgcggtcgcg tactggtccc agttcagctg tgtgcccacc
     7381 acggatcaac cgtagaagca cggcgcgggt gtcgtgtggc gggtggtcac acccgtgcgg
     7441 ccgcgcgcag ccgctgccac acctcgcggg tcgcggtgga ccggttgagc gtgatgaagt
     7501 ggatccccgg cacgccctcg tcgagcagct tctcgcacat ctcgctcgcc tgctccacgc
     7561 cgaggcggcg gaccgcctcg gggtcgtcgg ccacccgctc gaaccgctcg gcgagcgccg
     7621 gcgggaacgg cgcgccggac agctgcacgg agcgttcgat ggtgccgatc tgggtcaccg
     7681 gcatcacccc ggccaggatc ggcgtgtcgc agccggtggc ggccacccgg tcacgcagcc
     7741 gcaggtagtc gtcggcgtcg aagaacatct gggtgatcgc gaactccgcg ccggcccggc
     7801 acttgcgcac gaagtacgcg gtgtcgctgt ccacgtccgg cgaacgcggg tgcttgtacg
     7861 ggaaggcggc cacgccgacg ctgaagtcac cgctgtcgcg gaccagccgg accaggtcct
     7921 cggcgtaccg gacgccctcg gggtgggcga tccactcgcc gcccgggtcg cccggcgggt
     7981 caccccgcac ggccagcacg ttgcgcaccc cgaccgaggc cagccggccg atcacgtgcc
     8041 gcagctcggc gaccgagtgg ttcaccgcgg tcaggtgcgc catcggcagc agcgtggtct
     8101 cggtggcgat ccgctcggtc accgccaccg tggtgtcgcg ggtcgagccg cccgcgccgt
     8161 aggtgatcga gacgaacgag gggcgcagcg actccagctc gcggatggcc tgccagagca
     8221 gcttctcccc ggcctgtgtc ttcggcggga agaactcgaa ggagaaggtg gggcggccgt
     8281 cacggatcag ctccccgatg gccggctggg gattggggag gaccgaggga agaccgagcg
     8341 ccacggaccg actgtagccg ggagcgcacg gcttaccgag ggtcttccca gcccgcgaac
     8401 acttcgcggc gcgacgtcgt accccggggg tagaaagacc acagcgcggt ggggcggccg
     8461 acggccgtcc cgggggcccg cgcgggggtc gcacgactgt gacgcgccgg cgccagccgg
     8521 acgtccgcgt cgccatttca cgccgtcgcc cccggaggtc accatgatcc cgtcctggcc
     8581 gcccggtccg cggctgctcg ggccgctcct ggccgagctg cgggccgccc gcggctggag
     8641 ccagcagcgc ctcgccgccg agctctgcgc cgcctccggc gtgcccaccc tgacccggca
     8701 cgaggtgtcc cgctgggagc gccagctccg gctccccggc gacttctggt ccgcgtggct
     8761 ggcgacggtc ctgggcgtgc ccggcgagct gctcgccggg gccgccgcca gcagccgccg
     8821 gctcggcgtg acgccggtgg ccgtcgaccc ggccgggtcc cgggcccggc tggcgctgct
     8881 caccctggcg caccgctggg ccgccgaccc gggcggcggc acgctggccg gtccgttcac
     8941 cggcccggcg acaccgccgg tccccggacc ggccaccggc gacgggtacg gaccggcccg
     9001 cgccgccgac cgcgccggcc ccgtccgggg gcacccggcg gacggggcgt cactggccac
     9061 gctgcgccgc tgggacgacc tcctcggtgg cggcgacctc gccggcctcg gcgcccgccg
     9121 gctgcgccgc tcggtccgcg gctaccggcg cgccgggccc gccggccggc ggcggatgct
     9181 gccgtcgctg gccgagtcgg cgcagctcgc cgggtggctg gccgccgacg ccggcgacct
     9241 caccggcggc ctggtcgcct accggctggc gctgcgggcc gcggtggccg ccggggagcc
     9301 gccgctggcc gggcacgtgc tcgggtcggc cagccacctg ctgtccgacg ccggtgacgc
     9361 ggccggcgcg ctggtcctgg cccggatcgg gtacgcggcc agccgcgcca ccgcctcccc
     9421 ggggctgcgg gcgctgctgc tgcaccgggt cgccctcgcc gccgcgctcg gcgggcggcg
     9481 tcgcgccgcc ggtgaggcgc tggccggcgc cgaccgggcc gggccgccgg agcccggccg
     9541 ggagccgcag tggctctact ggctggacgc cgccgagctg gccgcgatga ccgggcgcac
     9601 gctcgtcgcg ctgggccggg ccgccgcggc cgtgccgctg ctgacgcccg tggtgacagc
     9661 gccgggccgc ccgcgccgct ccgccgtgta cggcggctgg ctggcccggg cgcacctggg
     9721 gctcggcgcg gagcccgagg cgtgcgcggt ggccggcgag gcgctgctcg acgcggtccg
     9781 ctccggttcg ccccgggccg tcggccagct caccgagttc cgccgcgggc tggcccgccg
     9841 tccgcccgga ccggcgaccc gggggtacgc acggctgctc gcggcgaccc gtccgtacct
     9901 gccgtcacgg cacccgtggc ggccgtcgcc gccggtgagc tgcgaggcac gccgggacgg
     9961 cggcacgacg ggagcgggcc cgaaccgcta gcgtcgtggc gtgacccacg ctgctcccgt
    10021 ttcccccgtc gaccgtgccg gcctgcgtca gcggatcgac aaggcgctca ccgagttcct
    10081 ggccggccag cgcggctggc tgaccgccgt cgacgacggc ctgctgcccg tcgccgaggc
    10141 gatcgaggcg ttcgtgctgg gcggcggcaa gcggctgcgc ccggcgttcg gctactgggg
    10201 ctaccggggc gccggcggag tcgactccga ccaggtcgtc gccgccctgg ccgcgttgga
    10261 gttcgtgcag gccagcgcgc tgattcacga cgacctgatg gaccggtcgg acacccggcg
    10321 gggcgagccg gcggtgcacc gcaggttcgc cgcccggcac cgggcggccg gctggggcgg
    10381 cgacgcggac gcgttcggcg actcggccgc gatcctgctg ggtgacctgt gcctggtctg
    10441 gtccgacgag ctgctgcact cctccggcct gccgccggcg acggtggccc gggcccggcc
    10501 ggtcttcgac gagatgcgca ccgaggtgac cgtcgggcag tacctggacg tgctgaccca
    10561 ggcgaccgct gacacctcgc tcgaccgggc ggccaaggtg gcccggtaca agtcggcgaa
    10621 gtacacggtc gaacggccgc tgctgctggg cgccgcgctg gccggcgccc cgcccgaggt
    10681 gcacgccgcc tactccgcgt acgggctgcc gctgggtgag gcgttccagc tccgcgacga
    10741 cgtgctgggc gtgttcggcg acccggagct gaccggcaag ccggccggtg acgacctgcg
    10801 cgagggcaag cggacgtacc tggtggcggc cgccctggag acgctcgacg aggccggccg
    10861 ggaggcgctg ctggccgggc tgggcgtacc ggacctggac gcggccgggg tggaccggct
    10921 gcgcgagctg atcacctcca gcggcgcgct ggagcgtgcc gaacggcaca tcaccgcgct
    10981 cacggagagc gcgctggccg cgctcaccgc cgtcgacctg gacaccgagg cccgccaggc
    11041 gctggtggac ctggccatag ccgccacccg ccgccccgcc tgacaaccac tccccccgcg
    11101 ctgtcccccg cctccgaagc ggtcgatcat gaagttggcg gcacttttgg agatcgactt
    11161 cgccgccaac ttcatgatcg acggggtggg tgggggtggg tgggtggggt gtgggttaga
    11221 aggccacggc ctgggctcgg cgtttgacct cgcgggccag gtcgccgccg agggccactg
    11281 cgggggtgcc gggaagcgac gggtcctccc ggtagagcca gcgcagcgcc tcctcgtcgt
    11341 cgtacccggc gtcggcgagc aggttgagca cgccgggcag gtgcttgagc acggtgcggt
    11401 tggccaccag gtcggccggg acgcggcgga cgccgtcgcg gcgcaccgcg agcagctcgc
    11461 ggtcgcggat catctggtgc accttgctga tcgacaggtc caggcgctcg gccacgtcgg
    11521 gcagcgtcag ccagccggcc gggtcggccg gtccggccag gtcggcgccg gtctcggcgg
    11581 gtacggaatc ggtcacccga ccaccctgcc acgtgcccgc cggatccggt gcacggcacc
    11641 ccccgacctg cgccggagcg cgccgggcca ccggtgtccc aacccggcgg tagcatcctg
    11701 ttctacgttc acccttccga cacatagact gcctgccgat ggacacacag gtcgccgaca
    11761 cgttgctggg ctcgctgatc gaggggcgct accgcattcg cggtcgcgtc gcccgtggcg
    11821 gcatggcgac cgtgtacacc gccaccgacg agcgcctgga gcgcaccgtg gcggtcaaga
    11881 tcattcaccc gacccaggcg ccgcaggccc gggcccggat ggccgggttc gtcgagcggt
    11941 tcaccgacga ggcgaagacg atcgcccggc tcacccaccc gaacgtggtg gcggtctacg
    12001 accagggcat ccacgccggc ctgccgtacc tggtgatgga gtacgtgcgc ggccgcacgc
    12061 tgcgtgacgt gctcgccgag cgccgccggc tgaacccgga cgaggcgctc gcgatcaccg
    12121 agcaggtgct cgccgcgctc gccgccgcgc accgggccgg cctggtgcac cgcgacgtca
    12181 agccggagaa cgtcctggtc gccgaggtgc ccgccggcgg cagccgcgac ctggtcgaca
    12241 gcgtggtcaa ggtggccgac ttcgggctgg cccgggccgt cgaggcgagc gcggaggacg
    12301 agaacggcaa ccagctcatg gcgacggtgg cgtacgtggc gccggagctg gtcacccagg
    12361 gccacgccga cccgcgcacc gacgtctact cggccggcat cgtgctgttc gagatgctca
    12421 ccggccgggt gccctacgac ggcgaccgcc cggtggaggt cgcctggcag catgtcgacc
    12481 gggacgtgcc ggccccgtcc acgctggttc cggcgctgcc gccggccgtc gacgcgctcg
    12541 tcgcccgggc cacccggcgc gacccggccg cccgtccggc cgacgccgcg gcgctgctga
    12601 ccgaggtgca ggcggcccgc gaggaactgg gcaacccgca cacgcacacc actgtcctgc
    12661 gtcagctcag cgacgacacg gcggtgctga gccagccgac gcaggtggtg gccgcgctgc
    12721 agccgatcga gcgcccgtcg tgggcccggc tgcccgaggg cgccgccacg cagcgcccgc
    12781 accgccgacg cgccgccgaa ccggaggggg tgggcgcccg gttcgccgcc ctgcgtaccc
    12841 ggatcatggg ttcgccgcgc ggccggctgg ccgtcgccgc ggcggtcgtg gtgctcggcc
    12901 tggtcgccgc cgtcggcggc tggtggttcg gcgtgggccg ctacacggtc gcgccgcaga
    12961 tggtgagcct caccaaggcc gaggcggagg cgcaggccca gcgcggtggt ttcacgctgc
    13021 gctacgccga cccccggtac gacgagaacg tcccgaagga caccgtgctc gggcaggcgc
    13081 cgggctcggc cgcccggatc gtcaagggcg gcacgatcac gctgaccctg tcgctcggtc
    13141 cggagcgcct gccggtgccg gacgtggtgg gcaaggactt cgcgctcgcc caggtggagc
    13201 tggagggtct caacctggtc gcggccaagg gcagctcccg ctacgacgac gcgctgccgg
    13261 cgggtgtcgt gctggccacc gacccgaagg tgggcactga ggtcaagccc ggggccaagg
    13321 tgacgctgat cctcagcaag ggccgcgccc cggtgagcgt gcccgacctg gtcggcaaga
    13381 gcctcaccga ggcgcgcgcc atcctcgcgc ggctcgggct caagccggtg gagaacgtca
    13441 aggagtccga caagccgaag gacgagatcc tcggccagag cccggccgac ggcaccggtg
    13501 tggaaaaggg cgcccaggtc aagctggaga tcagcaaggg cccgccgcag gtggccgtgc
    13561 cccgggtggt cgacatgccc tgccagcagg ccaagcagac gctggagagc cagggcttcc
    13621 cggtcaacat ccagctcaac ccgaacggca tcgtccggat ccagaacccg gccgagaaca
    13681 cgccggtgcc gccgggcacc acgatcactg tgacgtgcct gtgagcgcgg cgaacgggtg
    13741 ccggccggtg gggtcgcaca cccccacctc cggtggcctg gcgcgggcgg ccctgccgta
    13801 cgcggatgcg gccgagtccg aggtggtgca ggtctacgtc tcgaactcgc gtggctgggc
    13861 gctgccggcc ggtgacccgg cgcaggacgc gctgttccgc gacggctgcg ccgagcgtgg
    13921 cctgcccgtg ttcatccacg cgtcgctgct ggtcaacctc ggctccccca cccccgcgac
    13981 ggtcaccagg tcggcggaga cgctcgccca cgcgctgcgg cggggccggg cgatcggcgc
    14041 cgagggcgtg gtgttccacg ccggcagctc ggtggacgcc gggcacgccg aggcggccct
    14101 gcggcaggtc cgggagtcgc tgctcccgct gctcgacgag accgcggcca ccggcgggcc
    14161 gatgctgctg gtcgagccga gcgccggggg cggccggtca ctggcgtccc gggtcgagca
    14221 cctcggcccc tacctcgacg cggtcgaccg gcacccgatg ctgggcgtct gcttcgacac
    14281 ctgtcacgcc tgggcggccg ggcacgacct ggccgccgag ggcggcatga ccgccacgct
    14341 cgacacgctg gtcgccacgg tgggcgccga ccggctgcgg ctggtgcacg cgaacgactc
    14401 gaaggacctg tgcggctcca cccgggaccg gcacgagaac atcggcaagg gcaccatcgg
    14461 cgaaccggcg ttcgccgagc tgatgcgcca tccggcggcc gccggcgtac cggtgctggt
    14521 ggagaccccg acggagaagc acgtcggcca cgccgccgac atcgccgccc tcaaacgcct
    14581 gcgcccctga cacagccgtt tcctcccgcc ctcgccacgg cgttgccgga gggtcaggcg
    14641 cgcagggcgg tgtcgaggat ggtggcggcg ctgtcgatct gctcgtcggt gacgtccagg
    14701 tgggtcacca accgggcggt acgcgggccg agcaccgaga tcagcaggcc ggcttcccgc
    14761 gcggccgccg ccagcgcgtg cgcgtcgaga gggtgcttgg tcaggtccag cggcacgatg
    14821 ttcgtccgca ccaccgacgc gagcaccccg tgcggggcga ccgcctcggc cagccgggcc
    14881 gccttcgcgt ggtcctcggc gagccgctcg acgtggtgcg ccagcgcgta ccggccggcg
    14941 gcggcaagaa tgccgacctg ccgcatgcca ccgcccatcc gcttgcgcag gacccgcgcg
    15001 cgggcgatct tctccgcgct gcccaccacc agcgagccga ccggcgcgcc gaggcccttg
    15061 gagaggcaca ccgagagcgt gtcgaacagc tccccgtacc cggccagcgg caccctgtcc
    15121 gcgacgtgcg cgtgccagat ccgggcaccg tcgcagtgca gcgccacccc gtgctcgtcg
    15181 gcgacctcgc gcatgcgtcg cagcgtcggc agcgggatca ccccgccgcc gccccggttg
    15241 tgggtctgct ccaccgcgat cgcgcgggtc ggcaccgcga agtagccgtc cggccggatc
    15301 atcccggcga ccacgtcggg gtccaggtcc gcgcccaccg ccggccacgt ccgcgacgag
    15361 atcccgccgt acgcggcggc ggcccccacc tcgtacgtga ccacgtgcgc gtcggcgtcg
    15421 cagagcaact cgtcgccggg cggcacgtgc aactgaagcg cgatctggtt ggccatcgat
    15481 ccgctcgggg cgaacagcgc cgcctcgtgg ccgaacagcg cggccacctc cgcctccagg
    15541 gcggcgactg tggggtcctc gccgtagacg tcgtcgccca cctcggcggc ggccatcgcc
    15601 tcccgcatcc ccggcgtcgg ccgggtcacg gtgtccgtcc gcagatcgat cagttcagcc
    15661 acggagcctc cttcggctgc cgactgcggg gctcgcaagc tcactcctcg cgtcagccac
    15721 ggagcatctc cgccaccagg aacgccaact ccagcgactg ctgggtgttg agccgggggt
    15781 cgcaggcggt ctcgtaccgg tcgggcaggt cgaggtcctc gatgccctgg gcgccgccga
    15841 ggcactcggt gacgtcctcg ccggtcagct cgacgtgcag gccgcccggg tgggtgtcga
    15901 ggccgcggtg cacctcgaag tagccgagca cctcgtcgac gatccggtcg aagtgccggg
    15961 tcttgtagcc gttcgaggac tcgtgcgtgt tgccgtgcat cgggtcgcac tgccagacga
    16021 ccttcgcgcc ggcggcggtg accttcgcca cgatcggcgg cagcgcgtcg cgtacccggt
    16081 ggttgcccat ccggctgatc agcgtgagcc ggccggggat gttgtccggg ttgagcttct
    16141 cgcagagctc gatcgcctcg tccggcgtgg tggtggggcc gagcttgacg ccgatcgggt
    16201 tggcgatgcg ggagatgaag tcgatgtgcg cgccgtcgat ctgccgggtc cgctcgccga
    16261 tccagaggaa gtgcccggac aggccgtacg ccttgtggtc ggagatccgg gtcagcgccc
    16321 ggtcgtactc cagcgccagc gcctcgtgcg agcagtagag cgtgacggtg cgcagcgcct
    16381 cgtcgtcggt catcccgcag gcccggatga gggccagtgc ccggtcgatc tcccgggcga
    16441 tcgcgtcgta gcgctccccg gccggggact gccggacgaa gtccttgttc cagtcgtgca
    16501 ccgcgtgcag gtcggccagg ccgccggcca ggtacgcccg gagcatgttc atcgcggcgg
    16561 ccgagttggc gtacgcccgg atcatgcgct gcgggtcggc gacccgcgcc tccggcgtgg
    16621 cctccagcga gttgatcatg tcgccgcggt aggcgggcag cccccgggcg tcggtcggca
    16681 gggaccgggg cttggtgtac tggccggcca cccgggccac cttgaccacc ggcagtgacg
    16741 cgccgtacgt gagcacgatg gccatctgga gcagcgtgcg ggcgttggcg agcaggtggc
    16801 tctcggtgtt gtcggcgaac gtctcggcgc agtcaccgcc ctggagcagg aacgccttgc
    16861 cctcgcagac cagggccagc cgctgccgca gctggtcgac ctcgtagggc gcgaccaccg
    16921 agggaaccgt gtccagcacc cggcagacct cggcgacctg ggccgggtcg tcccacggcg
    16981 gggtctgcgc gcgcggcagc tcccgccatc ggtcgaggcc gagggctgcg tcctcggcgg
    17041 agtcggcggt cgggcggctg gtctgcaggc cagggctgcc cacggcgggg tgactcagct
    17101 gatgccactc atggcgcatg gaggaaagcg tacggcgacc gtcgcgatca ctcgtcgccg
    17161 aggggcatgg ttccggtcac tgggaggaga ccggcgaggg ccgcgccgcc ggcggcggct
    17221 cggacgggtc ggccgtgcgg tcgccgggaa cctcgccgga gatgcaccag tccgccccgt
    17281 tacgggtcac cgtgaacagc agtgaccggg tggccttgcg cgatccggcg gccaccgtga
    17341 cggaggcgct gacctcctgc ccgttcgggc cggagcggac gtcggtgatc gtcgcttcgg
    17401 gcaccgtgaa gtggtcggcg aagtcaccgt tcgggccggt ggcggcggcg tcgaaggcgg
    17461 cgtgcatggg cgcgcagagc tggctgcggc cggcgtcggc gtcgcgggcg gtgagcgcgt
    17521 cgaggtacgc ctgcacgcgc tcccggctct tggccgccgc ctcctcggcg ggcgcccggc
    17581 cgctgggcgc ggtggcggcg ccgtccgggc cggagccgca ggcggccagc gccggcgtga
    17641 gcgcgaaggc gagggcgagc gcggcgaacc ggccgcggtg gctgcgatcc atcggtcctc
    17701 ccgtcgcgtg gactcgtcga gcggcgagtg tgccacaccc ggcccggccg gccgggtgac
    17761 tccccatcct gacccggatc ggcgcgctct gccagaacgg cacgcgggcg gggaggggcc
    17821 ggtacggccc ctccccgccg ggtgggtggt gcgtcggccc tcggctcagc cgagaccgcc
    17881 cttgatggcg ccgatcagct caccgttgct ggtgtcaccg gagagctccc agaagaacgc
    17941 gccaccgagg ccctggctgt tggcgtagct catcttcccg ccgatggtcg ccggggtgtc
    18001 gtagctccac cagttgctgc cgcacttggc gtacgcggtg ccgccgaccg tgccggtggc
    18061 cgggcagctg ttcttgagca ccttgtagtc ctcgatgccg gcctcgtagg tgccgggggc
    18121 cgcgccggtg gcactgccgc cgggcgcagc ctgggtcacg ccggtccagc cgcgtccgta
    18181 gaagccgacg ccgagcagca gcttgctgga cggtacgccc ttggacttca gcttctggat
    18241 cgccgcgtcg gaccagaagc cctgctgcgg gatgcccgag tacgagtaga gcggcgagtg
    18301 cggcgcggtc ggcccctggg cgttgaaggc gccgaagtag tcgtacgtca tcggcatcag
    18361 ccagttgagg ttcgtcgcgg cgcccgcgta gtcggtcgcg tcgatcttgc cgccgttgct
    18421 gccgtcggcg gtgatcgccg cggtgaccag gaagctggag ccgaacttgc tccgcagcgc
    18481 cgagaccacg ttcttgaagg cgttcgggcc gctgctgtcg cactggaggc cgcaggcgtt
    18541 cgggtactcc cagtcgacgt cgatgccgtc gaagacgtcc gcccagcgcg ggtccttgac
    18601 cagggagtag caggagtcgg cgaacgcggc cgggttctgc gcggcctggg tgaagccgcc
    18661 ggaccaggtc cagccaccga aggaccagag gaccttcagg ttcgggtaca tcttcttcag
    18721 cttgcgcagc tggttgaagc tgccgcgcag cggctggtcc caggtgtcgg ccacgccgtc
    18781 gacgctgtcc gcggcggtgt acgccttctc gtagtcggcg tagctgtccc cgatgctgca
    18841 ccggccgccg gtggtgttgc cgaaggcgta caggatgtgg gtgagcttcg cggccgagcc
    18901 gctggtgtgg atgttcttga cgtggtagtt gcgggcgtag acgccccact cggcgaagta
    18961 gccgacgacc ttcttgccgc cgggcggcgg cgtggtgggc ggctgcgtgg tcggcggggc
    19021 ggtcgtcggc ggcgccgtgg tgggcggcgc ggtggtcggc ggcgccgtgg tcggcgcggt
    19081 ggtcgtcggc gtgccgccgc cggtgcaagt gccgccgttg atcgtgcagc tcaccggcgc
    19141 cttgtagccg ccggtgccgt tgtagcccca gctgaagctg gcgcccgggg cgagcgtcga
    19201 ggcccagctc ttgttgacag ccacgtagcg gtcaccgctg cgggtgatgt cggcgtccca
    19261 ggagctgctg atcgaggtgc cggagggcag cgtgaactcg atgcgccagc cgttgacggt
    19321 ggagctggtg ccgttggtga cggtcacccg cccttcgtgg ccggtccccc agtcctgcac
    19381 cttggcgaag gtggcggtga cgctgccggc ggccgacgcg gtggtcatgg gcaccgcggc
    19441 gaccgcgagc gcgaccacgg cgccggtggc ccacagggcc cggcggagcg atctcttcat
    19501 acggcgtccc tccaatagtt aggaaagttt ccaaattgat tgctgagacg ctactcacgc
    19561 cgtcaccact tcgtcaagat gtagatgcgt cgatttcacg ggtggcgcgg tacggtccgc
    19621 gtgacggccc gtagcctcgt cacatgaccg ttttcgacgt ccagatcgac gccctcaccg
    19681 gcggaccggc cgacctcggc cgctaccgcg gccgcgccct gctcgtggtc aacgtggcct
    19741 cccgctgcgg cctcaccccg cagtacgcgg gccttcagga actcgccgac acgtacgccg
    19801 ggcgcgggct cacggtgctc ggggtgccgt gcaaccagtt cgccggccag gagccgggca
    19861 gcgccgccga gatcgaggag ttctgccagg tcaactacgg cgtgacgttc ccgctgacgg
    19921 agaaggtcga cgtcaacggc ccggaccggc acccgctcta cgccgaactg gtgtccacgc
    19981 cggacgccga ggggcacacc ggcgacgtgc gctggaactt cgagaagttc ctcgtcgccc
    20041 cggacgggac agtggccgcc cggttcgccc cgcaggtcac ccccgaggac cccgagctgc
    20101 gcgcggcgat cgagaaggtc ctgccggcct gacgggcaca ccgccgccgg acacggcgaa
    20161 gcggcacgcc cccgcgggga ggcgtgccgc tgccgcggac cgggtcagcc ggcggcggac
    20221 cggaagaccg ggtagtagcc gccagactgc ccggccgccg tcgggtggta cgacttgctc
    20281 aggctcagca cgttgagcgc gtgcagccac ttggtcccgc cgctgcacag ctggtggccg
    20341 acgaagatgg agcggacgtc ggcgaatttg aagccggctg agacggcggc cgtgcgggtg
    20401 atgtcgtcga gcaggttgat gccctcgttg atcttcgccc gggacgtggc gctgagcccg
    20461 acacaggtcg tgccgagctg gtagaagacc gggtagccga ccaccacgac gcgggccgag
    20521 ggcgagcggc tcttgatgcc gttgtagacg ttggcgaggc ggcccggcat cgaggtgcgg
    20581 gccacgttca tggcggactg cacggccgcc acgcactggg tctccccctg gagcacacag
    20641 gtgctcatga tgttggcgaa gcccacgtcg ttgccgccca cggtgacgct gaccagcgtg
    20701 gtggtcgagg agagcgcgga gagctggctg ttgatgacgt cggccgtggt ggcgccggag
    20761 caggccaccg atcggtacga cgccggcttg atgttggcgt tgtagagcgc cgggtaggcg
    20821 ttcgtgctgc gtaggcagtt accgctctcg gacgtgtagc tgtcggcgcc gacgccggag
    20881 gcgtacgagt cgccgagcgc gacgtagcgg tcggacgggg ccgcctgggc gggggcggcc
    20941 agagacagag tgaccccgac cgaggcggcc agggtcaggg cgagggtggc aagacgggat
    21001 ctccgcacgt cgcactcctg gaggcgtgaa gtggtggtga gagatagata tcaataagat
    21061 cacagcgcat ggaagatcac cga
//
