LOCUS       NZ_CP118233            25070 bp    DNA     circular CON 13-JUL-2024
DEFINITION  Micromonospora chalcea strain 1K05785M01 chromosome, complete
            genome.
ACCESSION   NZ_CP118233
VERSION     NZ_CP118233.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora chalcea
  ORGANISM  Micromonospora chalcea
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Study on the Growth Characteristics and Drug Resistance Related
            Proteins of Micromonospora chalcea MCCC 1K05785
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-FEB-2023) Tianjin University, Tianjin University,
            Weijinlu Nub92, Tianjin, Tianjin 300072, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2022
            Assembly Method                   :: CLC NGS Cell v. 5.29
            Assembly Name                     :: TJU-micro-1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028768405.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 23:01:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,224
            CDSs (total)                      :: 6,161
            Genes (coding)                    :: 6,110
            CDSs (with protein)               :: 6,110
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 16 of 51
            Pseudo Genes (incomplete)         :: 40 of 51
            Pseudo Genes (internal stop)      :: 2 of 51
            Pseudo Genes (multiple problems)  :: 7 of 51
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:37:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2505175
            Orig. end                         :: 2530245
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP118233.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25070
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="14"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25070
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25070
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15070](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15070)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(811..1527)
                     /db_xref="GeneID:91356591"
                     /locus_tag="PVK74_RS10530"
                     /old_locus_tag="PVK74_10530"
     CDS             complement(811..1527)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356591"
                     /inference="COORDINATES: protein motif:HMM:NF013980.4"
                     /locus_tag="PVK74_RS10530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10530"
                     /product="SprT family zinc-dependent metalloprotease"
                     /protein_id="WP_274478959.1"
                     /transl_table=11
                     /translation="MQVTTSRPPALLRIGDLDIAVTVSERRRSVRLTVERDASITAVIP
                     PLVSCNELVRIVKAKRSWLYGKLAEKRDMSESPPAKKYVSGEAFLYLGRFYRLRLVEAP
                     AVRLFRGRLELPDGGGAEDLVGWYRRVGQPWLTRRVQPWTSRMGSPITGLRVRPLGYRW
                     GSCSKDGTVNIHWAVMQLPPTLIDYVLVHELAHLHRRDHGAEFWRIVGRAMPGHEEYRE
                     RLRTAGNNLWLPNEPR"
     gene            complement(1533..4760)
                     /db_xref="GeneID:91356592"
                     /locus_tag="PVK74_RS10535"
                     /old_locus_tag="PVK74_10535"
     CDS             complement(1533..4760)
                     /EC_number="3.1.21.3"
                     /GO_component="GO:0019812 - type I site-specific
                     deoxyribonuclease complex [Evidence IEA]"
                     /GO_function="GO:0009035 - type I site-specific
                     deoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356592"
                     /inference="COORDINATES: protein motif:HMM:TIGR00348.1"
                     /locus_tag="PVK74_RS10535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10535"
                     /product="HsdR family type I site-specific
                     deoxyribonuclease"
                     /protein_id="WP_274478960.1"
                     /transl_table=11
                     /translation="MAGGLEYSLVEKPLIEQLQQMGWRHLEGAAHDEVIPTVPAASGRV
                     SFDEVILEDKLRAALRRINKNPLGEEWLTEDRISLAINGLTRTAPASLLDINRAATELL
                     LRGVAVEGVEGWEGGKTRTIHFIDWHHLANNEFTVVNQFRVDIPGGRGPIVPDLVLFVN
                     GIPLVVVECKKTTETSLNVAIGQIRRYAEQVNSEYRVGNQKLFHTVQLTVATSGEDARL
                     GTFTAEADRYIPWRDPYPLTQEELASLRGKSAAQLSRQEILAAGVLDPANLLNIVHNYV
                     TVMTTNQGKIVKVAPRYQQFRAVEKAIKRLHTGKTRRQDGAGDRRGGIIWHTQGSGKSI
                     TMTFLVRRLRFTPDLADFKVVVVTDRTQLQDQLSATMSLSGEMVYTARTASRARTLLGR
                     RGPAVVFVMIQKNQAGDGVTAATSLGEVMNADESIVVLIDEAHRSHTASLGANLREALP
                     NAARIGFTGTPIMTRKGIRKTSIDLFGPFIDTYRLREAEEDEVIVPILYEGVKVKAAVR
                     DSQDLDDIFEDEFVDLGPEEREELQRRWVTKGRVSAARQLIDAKAKHMLLHYVDNVLPE
                     GFKAQLVAYDREATVSYREALLEARDELVAAIEKLPPDVLAMRAEEIRNSSRARLVRAA
                     RHLDLLKRIDFLPVISKGEAENEHRLAEWSDETKQRDRIASFLRPFGENDTAFIIVRTM
                     LLTGFDAPIAQAMYLDRQLEEHDLLQAVARVNRTAARKTHGRVVDYRGVARNLLEALRV
                     FADEGFSVDEGKDVRGALMDARLHVAKLEPQAQRLRLMFRYPEDVERCVQALAEPELRD
                     RFDAELARFARTVNTVLPDPAAKPYLPDLKRFMVIKLMATRRYRIDSGDFDPRAYGAKI
                     RALIDEHIASLGIEQQLPPINMTAPGFAAKVEAMAGGPRAKASEMENAIRYHITVHRGE
                     DPARYQKLSERLEIILSELKDDWDQQLLALNKLMEEIVHATPEDDSGLNEVEARLHRTM
                     TAELATSPDDLDDPRFTDATRDLYQLATRTIHRQDFWRKTVDQEELRREIFEILYERSL
                     GDYVQLDQLASTLLDVLKSNRRLIPKA"
     misc_feature    complement(1578..1580)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2331..2333)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4840..6057)
                     /db_xref="GeneID:91356593"
                     /locus_tag="PVK74_RS10540"
                     /old_locus_tag="PVK74_10540"
     CDS             complement(4840..6057)
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356593"
                     /inference="COORDINATES: protein motif:HMM:NF013579.4"
                     /locus_tag="PVK74_RS10540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10540"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_274478961.1"
                     /transl_table=11
                     /translation="MPSVPGGWRRFTLSDITLEEAERVGGRRGVTVLSSTKHLGLVPSD
                     EYFKNRSVYSSNLSGYRVVRRGWFAYATNHLAEGSIGLQQDFELACVSPIYTVFSCTDE
                     VYPPYLFRVLKSPDLIAKYGVHEQASVDRRGAVRYRDFSRIEVALPPQQDQRRIVEILD
                     TIEDQIANQRLVVEKTSHITAALIEAELRRITGLAASTASLGSVATVATGVTLGTETGG
                     TVEVPYLRVANVQDGYIDTTEVKSVRVSKSDAQRYMLRAGDVLLTEGGDFDKLGRGAVW
                     DARIDPCICQNHIFRVRCDRSRLLPAYLAAYTSSNQGKQYFLSIAKQTTNLATINSRQL
                     KAMPVPIPPLEAQHELLSLLAAQKTSTSTEGARLHQLILLRHGLTEDLLTGRIRVAEAG
                     ARLEDV"
     gene            complement(6050..8491)
                     /db_xref="GeneID:91356594"
                     /locus_tag="PVK74_RS10545"
                     /old_locus_tag="PVK74_10545"
     CDS             complement(6050..8491)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008170 - N-methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006306 - DNA methylation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356594"
                     /inference="COORDINATES: protein motif:HMM:NF014442.4"
                     /locus_tag="PVK74_RS10545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10545"
                     /product="N-6 DNA methylase"
                     /protein_id="WP_274478962.1"
                     /transl_table=11
                     /translation="MARLTLPQLERHLFGAADILRGKMDASEFKEYIFGMLFLKRASDQ
                     FDVVREQLVRKWKAQGKSPDEAERMADAPNFYRGESFYVPLDARWQYIKDNSRRKNVGE
                     LLNTALSSLGEVNSAALEGVLEHIDFMKKVGQSTIPDRRLQRLIDHFHRVRLRNEDFEF
                     PDLLGAAYEYLIAEFADSAGKKGGEFYTPRGVVRMMVRLVKPEPGMRIYDPCAGSGGML
                     IHAKEYVEEHGKDHRDLTLAGQEYNGGTWAISKMNMILHGVLNASLENDDTLANPLHHE
                     GDELMRFDRVLTNPPFSQNYVATDMRHPERFKYGFAPETGKKADLMFAQHVLAVLTPDG
                     VGATVLPHGVLFRGGREKKIREGIINDDRLEAVIGLPPNLFYGTGIPACILVLRGTAKR
                     RKDRQGKVLFINADREFTSGRAQNYLEPQHAEKIVSAFEEHRDIPGFARVVDVKELRNN
                     DFNLNIRRYVDNTPPPEPQDVRAHVHGGVPKTEVASKSHLFTAFGIDPASLLADRDAHY
                     FDFLPEGWESTAKRLPALARPAETRLRDVFTDWWTQHSKRLVELPDSRMVMEIRAELLD
                     SFVGELKPLGLLDRFELAGVVAAWWGETQYDMKTLALNGFEGVVEGWLTTIESAFELDE
                     EELEYWDKQKIEAEKRKARDHRVVPALIPDYLAELDEAEARYADLNAQLRAATARSDEE
                     DDEAQDPENQLTEAELRRLKADTAAARKDVTALANDFLPRLRTTAAALSPDERRALVLE
                     VLRQQLASRLDSRVAGARRLLEAAFRTWADKYAVTLRELEAQREAAAARLETYLKELGY
                     A"
     misc_feature    complement(6731..6733)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8874..8890)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.62"
                     /tool="antismash"
     gene            complement(8940..10004)
                     /db_xref="GeneID:91356595"
                     /locus_tag="PVK74_RS10550"
                     /old_locus_tag="PVK74_10550"
     CDS             complement(8940..10004)
                     /codon_start=1
                     /db_xref="GeneID:91356595"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PVK74_RS10550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PVK74_10550"
                     /product="hypothetical protein"
                     /protein_id="WP_274478963.1"
                     /transl_table=11
                     /translation="MNPAVARRFPLIARTRPVCTPLAQRVSDLQKRADLARQSGDVAAA
                     TAAFNLAALLASDCGMPDLARTWCHRLATAALDHGSDPQHALEPIVNLARLRIRAGDGL
                     AAWTLLETLFQAIDTRTDALIDGLTIPAARLTEASGTHTKTRTWLWTVLLGTGAHALAT
                     SGRWDEASHRLTQYNGVGVRMLDGRQITVIAHAIAGRHRQARAILDATKPGEPWENAVT
                     ACLHLLMPCSGDDQASTALTAYHALGPVKPGLIVFHTRLGLTLLDALDKDHPAAEQITV
                     ELTQYAADDGYAARDLLTHPTCLAAAPYQRVSQLKTLVSACGFDAGTLPAAHLRTLLRA
                     LDIAESVIARPRKR"
     gene            complement(10001..10822)
                     /db_xref="GeneID:91356596"
                     /locus_tag="PVK74_RS10555"
                     /old_locus_tag="PVK74_10555"
     CDS             complement(10001..10822)
                     /codon_start=1
                     /db_xref="GeneID:91356596"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018829355.1"
                     /locus_tag="PVK74_RS10555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10555"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_274478964.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-22, bitscore:
                     78.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPEWRQTTIAFPDPHTAEQAARTHLAPILAEAEARHLITTWFY
                     VRKDNWRLRYLPATTSDADRYLTSELERLKHARHIRAAVPGIYEPETHAFGGTEAMDTA
                     HRLWHHDSRHLLTRSTDHTPGRQRELSIMLSATMMRAASLDWYEQGDVWARVAEHRDPP
                     QPALVDSLLNAARRLLTVDPASLTRGQGAPLAGYHTLFEAHTSAGDTLRHLNQTGQLHR
                     GLRATLAHHVIFTWNRRGIPGLHQAALATAAKTIIFGPDPTHSTHTTGGKS"
     misc_feature    10778..10792
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            complement(10839..12062)
                     /db_xref="GeneID:91356597"
                     /locus_tag="PVK74_RS10560"
                     /old_locus_tag="PVK74_10560"
     CDS             complement(10839..12062)
                     /codon_start=1
                     /db_xref="GeneID:91356597"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="PVK74_RS10560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10560"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_274478965.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-37, bitscore:
                     128.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPTTTGNHLDLLGAVCARLASPSIVGPSPDGRTRPQSLAGGAA
                     GIALLHIERAVSGHGDEATAHHWIRAAANEPVSIGRNSDPFHGAPALAFMLHTAHPLGG
                     YHRARASLNDATITLTRQRLAAAHARIDRREPLTMYEFDLVHGLTGLGLYHLHAHPDHP
                     VSHDLASYLTRITEPVGDNAAQPPWWLPSGLGGTPDPDFPHGHGNIGMAHGISAVIALL
                     AYAILHGHDTPAARNALAALCDWTDHHRHDDPAGSWWPGYVTPDTTPRRHRPSWCYGTP
                     GIARAQQLGGLALHDEARQQQAENAMLAVLRDTTQRDRLPEIGLCHGKAGLVQSACRIA
                     ATSTDPQRSAQLTAELPGLAAELASQLAADTQRSAELMDGTAGAALALHTAATGTSATS
                     WDAFLALT"
     gene            complement(12059..15070)
                     /db_xref="GeneID:91356598"
                     /locus_tag="PVK74_RS10565"
                     /old_locus_tag="PVK74_10565"
     CDS             complement(12059..15070)
                     /codon_start=1
                     /db_xref="GeneID:91356598"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="PVK74_RS10565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10565"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274478966.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.3e-174,
                     bitscore: 578.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.4e-13,
                     bitscore: 49.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7e-21, bitscore:
                     73.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRSVNDALMLRAAVLRPGQLGVWPDLTSSDTAASWRLWLAEALT
                     IPEFAAALAHASPDLAERATAAINGGLSHANARRVVLAVMRYLLRAATRATPYGLFAGV
                     VVATASRTGRIRWGTAHRPVARLQAPWLAAVLDGLESDVRLRPHVMVRANNLLVERSEK
                     LVLEYRAATSDPYGAPTHLRIKANDMIRAALALAAEPIRWADLIGKLTAECGAPQEGAQ
                     RLIGQMVTQRLLLTSLRPPSTETDPLTHLVVQMETAAAEGGDVGELIDPLRRVRDLKAR
                     HDRAPDEATAAARRRELGVAAAVINPGQAVGVDLRLDCDLVVPTTVTAEACRAAAALTR
                     LARPTSLRWRDWHTRFLDRYGLHALVPVLDAIDVQVGLGYPDGFTGEPADASAVTDRDR
                     GLLALAQRAALRREHEVVLDDALLERLGGPAPTEIPPTAELTVRVHADSLQAIAGGDFL
                     LSVVRASPQAFSTAGRFLDMFGATERHRMASCATDSPTVSAGALLAQLSAVTRYTISLD
                     VNRAPQVLPHLIPVGEYHAPSEAAIGLDDIAVTADAHRLYLVSISRQQALQPVAVNAVE
                     PVRHAHPFARFLAEAPVALATPCTPVEWGPAAKGLPFLPALRYGRTLLSPARWHLNAAE
                     LPDRKAPWQQWDQALTAWREASGCPTAVSLGVGDQTLGLDLDGPAHRALLRDHLTRNPT
                     ALLRLIPEGDGWIGGHPHEIVIPLTATTARPPPPRLSSPLVDVRSHGSLPGSDHHYLKI
                     YARPEEQTTILTAHLPRLVGQLPPAGRWWFLRHADPEPHLRLRTSGLPIDAITGWTREL
                     TDADLTRRVQWDTDFGEPGRFGSPAAYQATTAVFAADSAAALAQLAVTARSSAPGWQAL
                     TAASMVDLVTAVIGDPHDALRWLIARTRAHRPAPPRAVYDQAIRLAKPYDPTAVASLPG
                     GENLMDRWAERRRIVAAWRDSLPTVSTVPPVELLPDLLHLHHVRVAGLDLDSERACLHL
                     ARAAALSWTTRSTS"
     aSDomain        complement(14348..14620)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PVK74_RS10565_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.40E-16"
                     /identifier="RREFam001.1"
                     /label="PVK74_RS10565"
                     /locus_tag="PVK74_RS10565"
                     /protein_end="241"
                     /protein_start="150"
                     /score="49.8"
                     /tool="antismash"
                     /translation="VRANNLLVERSEKLVLEYRAATSDPYGAPTHLRIKANDMIRAALA
                     LAAEPIRWADLIGKLTAECGAPQEGAQRLIGQMVTQRLLLTSLRPP"
     gene            complement(15242..15406)
                     /db_xref="GeneID:91356599"
                     /locus_tag="PVK74_RS10570"
                     /old_locus_tag="PVK74_10570"
     CDS             complement(15242..15406)
                     /codon_start=1
                     /db_xref="GeneID:91356599"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018724312.1"
                     /locus_tag="PVK74_RS10570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10570"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_274478967.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7.4e-16, bitscore:
                     56.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLATVQPDVEGCILDDFDLDIEFIEAGGTVEHIIKMTEDNCGS
                     TCASACTSC"
     CDS_motif       complement(15302..15406)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAQLATVQPDVEGCILDDFDLDIEFIEAGGTVEHI"
                     /locus_tag="PVK74_RS10570_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15242..15301)
                     /prepeptide="core"
                     /locus_tag="PVK74_RS10570_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-10.50"
                     /molecular_weight="1817.0"
                     /monoisotopic_mass="1815.7"
                     /core_sequence="IKMTEDNCGSTCASACTSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAQLATVQPDVEGCILDDFDLDIEFIEAGGTVEHI"
                     /leader_location="[15301:15406](-)"
                     /alternative_weights="1835.1"
                     /alternative_weights="1853.1"
     gene            complement(15485..16693)
                     /db_xref="GeneID:91356600"
                     /gene="fxlM"
                     /locus_tag="PVK74_RS10575"
                     /old_locus_tag="PVK74_10575"
     CDS             complement(15485..16693)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356600"
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="PVK74_RS10575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10575"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_274478968.1"
                     /sec_met_domain="PCMT (E-value: 3.1e-42, bitscore: 143.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLQVDDATTLRQAMVGTLRDEGLITTDSVAAAMNAVPRHEFAPG
                     EPLEKVYQTNSTLVPKIDAQGRQTSVVSASHIQAIQLELAEVRPGMNVLEIGSGGYNAA
                     LIAEVVGPTGSVTTVDIDADVVDRARAGLRRAGYEQVNVVLADAEHGVAQHAQYDRIMV
                     TVGAWDIPPAWLDQLTPDGRIVVPLRFAGITRLVAFDRAPGRSVLTASNYRLGSFVPMQ
                     GDGAASEQLIPVTPDVGLRLDQNSALTFDVPALRKALHTKPVESWSGTPFDMPDELELY
                     LLTSGPELPMLHAAQAAVDQGVVNRTVRNGTPTLVRGGSFAYRIKRENPQPVSGYETGV
                     IAHGPEAEQVGAELLAMIRTWADCYYRRGAAHITYHPNTADTSDLTGWHSTKRHGVLAI
                     AWS"
     misc_feature    16683..16693
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    16691..16706
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.9"
                     /tool="antismash"
     misc_feature    16693..16707
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     gene            complement(16808..18037)
                     /db_xref="GeneID:91356601"
                     /gene="fxlM"
                     /locus_tag="PVK74_RS10580"
                     /old_locus_tag="PVK74_10580"
     CDS             complement(16808..18037)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356601"
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018802441.1"
                     /locus_tag="PVK74_RS10580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10580"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_274479264.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-37, bitscore: 128.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEPRINADRAAQLRAALVDTLRDEGMVTRALVEAAVRVVPRERF
                     MPAGTPLEVAYAYDNSVVTKRDQHGMAISSVSAAYIQARMLELAELRPGMTVLEVGSGG
                     LNAAYIAEIVGPEGRVVSIDIDPEVIDRAATALDATGYSSRVRVLVADAEHGVPNEGPF
                     DAIIVTVGAWDIAPAWLGQLAPDGVLVLPLIMNGVTRTIGFRRDGDQLISTSAEVAGFV
                     PMQGAGSHANQVLELADTTGGKVKLSFDSGAPPDLIQLDGVLNAGAAEWWSGVTVSHGI
                     SFADLHLWLACYLDGFCRLAADEGSALAARKRWLPFAVVRGAGLACLVLRDAMQGAGAE
                     FGARAYGRDGQVAATALIEQIQAWDRAGRHTPPTFAYWPAGGDRSQIRADATVMNKTHG
                     VVTISWPTSS"
     misc_feature    18155..18165
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            complement(18291..19070)
                     /db_xref="GeneID:91356602"
                     /locus_tag="PVK74_RS10585"
                     /old_locus_tag="PVK74_10585"
     CDS             complement(18291..19070)
                     /codon_start=1
                     /db_xref="GeneID:91356602"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PVK74_RS10585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PVK74_10585"
                     /product="hypothetical protein"
                     /protein_id="WP_274478969.1"
                     /transl_table=11
                     /translation="MAVADTVGRAILARAARIIPSASTPTPPHLAAVHAHRVLARITVG
                     ATPSDVTLTWRATPAPEPGRFEAERAQRVATARNLVLSDPLRARQLLHDSLTGVDPATA
                     PADAVHAEAAILLAELQLRLGHPADAMSWATYARASTAHLHGPTHRRALHALHVLAAAH
                     SRGGHHQRAYHLYRELTGHLTKSDGPHAQQTLAVQAATALILHALGHCQAARTLLADTI
                     TTHRREHPGHPATAHMTRHLSRIWRECAINGHQHQDA"
     gene            complement(19489..20142)
                     /db_xref="GeneID:91356603"
                     /locus_tag="PVK74_RS10590"
                     /old_locus_tag="PVK74_10590"
     CDS             complement(19489..20142)
                     /codon_start=1
                     /db_xref="GeneID:91356603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285713.1"
                     /locus_tag="PVK74_RS10590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10590"
                     /product="N-acetyltransferase"
                     /protein_id="WP_274478970.1"
                     /transl_table=11
                     /translation="MESLVHIRAARWADKDLVALLIADALHPTPLAAWLVPKPGQRCQV
                     LTEVVAIWVEHALFFGDIHLTDDLTATAVGFHRYRPIPPPANYRTRLTDAAGPHADRFD
                     LLDTLLAKKQPTEPHYHLAFLAVRTDVQRGGCGVALLAHHRSRLDRIDLPSWTAVLAGG
                     EHLLARYGYTPRPAITLPDGPTLQPMRRNARHGSSVMPINPARPVDNRWHGFHA"
     gene            complement(20170..20844)
                     /db_xref="GeneID:91356604"
                     /locus_tag="PVK74_RS10595"
                     /old_locus_tag="PVK74_10595"
     CDS             complement(20170..20844)
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018792215.1"
                     /locus_tag="PVK74_RS10595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10595"
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_274478971.1"
                     /transl_table=11
                     /translation="MSFARLSLRDELFLLGHDDDAGHPHIHRQALALGLAGAVLIDLFL
                     AGRIVLDPNDDRLSGDRWLRLHTDQPLGDLIADSAIGFIRCGRAAPPVKAFLRGFADDL
                     YERTRAGLVAAGILRQVTRRRLGGLARTDTYLATDTKWAVVARARLRYVAQGREQPDNH
                     TAALAGLVATLGLTGHLYLNDDSTTVTAYLKAVAGQHHRSVRDITAALDAAVGDLATAP
                     YR"
     gene            complement(21010..21879)
                     /db_xref="GeneID:91356605"
                     /locus_tag="PVK74_RS10600"
                     /old_locus_tag="PVK74_10600"
     CDS             complement(21010..21879)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /db_xref="GeneID:91356605"
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018726147.1"
                     /locus_tag="PVK74_RS10600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10600"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_274478972.1"
                     /transl_table=11
                     /translation="MGTEAMSWAPAEVDLTRPNAARMYDYFLGGSHNFAADRHAADAVL
                     AVAPHVADAARANRAFLRRAVRYALQQGIHQFLDLGSGIPTVGNVHDITRHDDINARVL
                     YVDVEPVAVAHARALLGNDPRADVIQADICFPDFILQNPTTQRLIDLTRPVAVLFVSVL
                     HFIPGDVNAIVEPFRAAMPPGSALVISHATSGTATSQTDEVQRLYQRTPTPLQLRAPAE
                     VEALFGDFAMVPAHAPAAKSASNAALVPVARWRPDPEDQIERGHGSASPFLTGFLAGVG
                     MKGAAARE"
     gene            complement(21869..22894)
                     /db_xref="GeneID:91356606"
                     /locus_tag="PVK74_RS10605"
                     /old_locus_tag="PVK74_10605"
     CDS             complement(21869..22894)
                     /GO_function="GO:0016811 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in linear amides
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020217616.1"
                     /locus_tag="PVK74_RS10605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10605"
                     /product="acetamidase/formamidase family protein"
                     /protein_id="WP_274478973.1"
                     /transl_table=11
                     /translation="MTSTVTYQPTEDELRYTFGAHPAVAEIKPGSLLVTSTEDCFGGAV
                     RTVDDLPSKVCQAFNPVTGPFHVLGAEPGDTLGLHFAAITPARDWGMSATFPHFGALTA
                     THTTPMLHPPLEERVWRYTIDTAAGTVTFHARRSGHAIVMPLEPMLGTVGLAPAGGEAR
                     STVVPDAHGGNLDTPEIRPGTTVYIGVNAPGALFAIGDGHARQGQGEVCGVAVETAMNV
                     TVAVDLIKGVATPWPRIETDHRIISVGAARPLEDAYRISQHDLVTWTAQLTGLELLDAY
                     QVVSQAGRAAPGNVCDPLYTMHAALNKAILAGVNPYDGVHQRLRRIAEAPSEQPGKDHG
                     N"
     gene            complement(22891..24324)
                     /db_xref="GeneID:91356607"
                     /locus_tag="PVK74_RS10610"
                     /old_locus_tag="PVK74_10610"
     CDS             complement(22891..24324)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91356607"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018791140.1"
                     /locus_tag="PVK74_RS10610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_10610"
                     /product="APC family permease"
                     /protein_id="WP_274478974.1"
                     /transl_table=11
                     /translation="MHTRQIAPPPEIGLAQASPDSSRFGYRPELRRSLGFADLLFYGLV
                     FMVPIAPMGIFGSVYSGAGGMVALAYVIGMAALVFTAASYAQMVKAFPLAGSVYNYAGR
                     GIGAPVGFLAGWAILLDYVLVPSLLYLIAAVAMHSTVPAVPVWVWLVGFVLINTLVNYR
                     GIRMTALITRVMLVGEVIVLVIFLAAAGRALAQGKGQGFSWTPLYNPDTFTWALVFGAV
                     SIAVLSFLGFDGISMLAEENKGGAGQIGRAMGAALGVAGLLFIAQTWMAALLLPNPDGL
                     LVNGDPEGTAFYDAARLAGGPWLATLCAVATAVAWGVANSLVAQVATSRLLYAMARDRQ
                     LPKFLAKVSVRHSVPTHAITLTALVSLTIGLYMNWRDDGIALLSSLINFGAMTAFLVLH
                     LAVIWHYLVRRRSRNLIAHLILPGIGFAILAYVVVNANVAAQRLGFVWLTLGLLALAGL
                     YAAGRRPELSGLASGREAA"
ORIGIN
        1 gcgccaagca gggacatgag cggttgtgga gagaagacgc ctacgacaaa ctgttcggac
       61 tcaagatcaa cgcctaccgc gtctggcgct ctgtattgct gctgcgcgca gtgaaggagg
      121 agttggacgg ggcacagaat gacgtggtcg gtcgagctgc ccaggttgca attcacggtg
      181 atttggcgat tgtcaacatc gtcggtcggc atctggatct gcgcgggatc agcgatgctg
      241 agacgaactg ggacccggtc gtggcacaag cgcgacagtt gacgagggca acactctcgc
      301 tgctggttag gcaggttgat cacctgatgc cgaccagcta tctgcagacg gtgttcaagt
      361 ccgaggagaa aactcgcctg ctcctcggct atgccccgcc gcaggcccgc atcgtggagg
      421 aggtcgcgga tcttccggac aagtatcgag cgaccaagcc agagcgcaag agtaacgctg
      481 tcggagtcat cgtcgacgcc ggtgccatcg ctgacggcac cgcattggag ttccgggcac
      541 gaaccgggcc ggagcgcaga gcgcttgacc tctggttggc tgaggaccct cgtcgtggtc
      601 gtgcaacgtg ggttactcac cgccgtaacc cattgctctg ggaagccgat ggcaagcagt
      661 attcgccgac ggcgcttgtg cagctcatgg tcaagctggc gacagggacc agactcaaga
      721 cggttcaggg aacaagccgt tggttcgtgc cgggtgcggg gtcgcttgtg gatatcgcaa
      781 acgttgctcg tgcggacata tccgaatgag tcatcgaggc tcgttgggaa gccacagatt
      841 gttccccgct gtccgtaggc gttcgcggta ctcctcgtgg ccaggcatag cgcgcccgac
      901 gatgcgccaa aactctgccc cgtgatcgcg acggtggaga tgcgcgagct cgtggacgag
      961 cacgtagtcg atcagggtgg gcggaagctg catcaccgcc cagtggatat tgacggtgcc
     1021 gtccttggaa caggatcccc aacggtagcc aagagggcgg acgcgaagcc ccgttatcgg
     1081 tgaccccatg cgcgacgtcc aaggctgcac gcgtctggtc agccacggct gcccgacgcg
     1141 ccgataccag ccgaccaaat cctcagctcc gccaccatcc ggaagctcca gccggccacg
     1201 gaacagcctg acggccggcg cctcgaccaa cctgaggcga tagaaacggc cgaggtagag
     1261 aaatgcttcc ccggagacat acttcttagc gggcggcgat tcactcatgt cccgcttctc
     1321 ggccagtttg ccatagagcc aggacctctt ggccttgaca atcctcacca gttcgttgca
     1381 tgaaacgagg ggcgggatga cggcggtgat cgaggcatca cgttcgacgg tgagccggac
     1441 actcctacgg cgctcgctca cggtcacagc gatgtccagg tcgccgatgc gtaggagggc
     1501 tgggggccgg cttgtggtca cctgcatggg tgtcacgcct ttggtatgag gcgccggtta
     1561 ctcttgagca catctagtaa agtactggcg agctgatcaa gttggacgta gtcacccaag
     1621 gatcgctcgt aaaggatctc gaagatctcg cggcgcagtt cttcctggtc gacagtcttt
     1681 cgccagaagt cctgacgatg gatcgtgcga gtggccagct ggtagaggtc ccgggtcgca
     1741 tcggtgaacc ggggatcgtc gagatcatcc ggtgacgtcg ccagctcggc agtcatcgtt
     1801 cgatgcagcc gtgcctcgac ctcgttgagg ccggagtcgt cctcgggcgt ggcgtgcacg
     1861 atctcctcca tcagcttgtt gagcgctagt agttgctggt cccagtcgtc cttcagctcg
     1921 ctcagaatga tctccaagcg ctcgctgagc ttctggtagc gggccgggtc ctcgccacga
     1981 tgaacggtga tgtggtaccg gatggcgttc tccatctccg atgccttcgc tcggggaccg
     2041 ccggccatgg cttcgacctt cgcggcgaac ccaggcgcgg tcatgttgat gggcggcagc
     2101 tgctgctcga taccgagcga ggcgatgtgc tcatcgatca gcgcacgaat cttcgcaccg
     2161 taagctcgcg gatcgaaatc accggaatct atacggtatc gacgtgttgc catcagcttg
     2221 atgaccatga agcgcttcag gtcgggcaga tacggcttgg cagccggatc gggcaggacc
     2281 gtgttgacgg tccgggcgaa ccgggcgagc tctgcgtcga accgatctcg taactccggt
     2341 tcggcgaggg cctgcacgca ccgctcgaca tcctcggggt accggaacat cagacgcaac
     2401 cgctgtgcct gcggttccag cttcgccacg tgtagccggg cgtccatcag cgcaccgcgg
     2461 acatctttgc cttcgtcgac ggagaacccc tcgtcggcga acacgcgcag cgcttcgagc
     2521 aggtttctgg cgacaccacg gtaatccacg acgcggccat gggtttttcg ggcggcggtg
     2581 cggttgaccc tcgctacggc ttgcagtaga tcatgctctt cgagctgcct gtcgaggtac
     2641 atggcttgcg cgatcggcgc gtcgaacccg gtgagtagca tcgtgcggac gatgatgaag
     2701 gcggtgtcgt tctccccgaa cgggcggaga aagctggcga tacggtcccg ttgcttcgtc
     2761 tcgtcgctcc attcggcaag tcggtgctcg ttctccgcct cgcccttgga gatcactggg
     2821 aggaagtcga tccgcttcaa caggtcgagg tgcctggcgg ctcggaccag acgcgcgcga
     2881 ctggagttgc gtatctcctc agcgcgcatg gcgagcacgt cgggcggtag cttctcgatg
     2941 gccgcgacca gctcatcccg ggcctcaagt agcgcctcgc ggtagctgac tgtggcctcc
     3001 cggtcgtaag ccaccaactg cgccttgaac ccttccggca gcacattgtc aacatagtgc
     3061 agcaacatgt gtttggcttt ggcgtcgatc agttggcgtg ccgccgagac ccttcccttg
     3121 gtgacccaac gccgctgaag ctcttcgcgt tcttcagggc cgaggtcgac gaactcgtct
     3181 tcgaaaatgt catcgaggtc ctggctgtcc cggaccgcag ctttgacttt cacgccctca
     3241 tagaggatcg ggacgattac ctcgtcctct tcggcctccc tgagccggta ggtgtcaatg
     3301 aacggaccga acaggtcgat gcttgtcttg cggatgccct tcctggtcat gatgggcgtg
     3361 ccagtaaagc cgatacgggc ggcgttaggc agggcctcgc ggagattggc gccgagcgag
     3421 gcggtgtggg aacggtgtgc ctcgtcgata agtacgacga tggactcatc tgcgttcatt
     3481 acctcgccca gcgatgtggc cgcggtgaca ccgtcgccgg cttggttctt ctggatcatc
     3541 acgaaaacca ctgctgggcc gcgcctgccc agcagcgtcc tggcgcgaga ggccgtcctt
     3601 gccgtgtaca ccatctcgcc gctgagactc atggttgcgc ttagctgatc ctgaagttgg
     3661 gtgcggtccg tcaccacgac aaccttgaag tccgcgaggt ctggggtgaa ccgcaggcgg
     3721 cgtaccagga aggtcatggt gatgctcttg ccggagcctt gcgtgtgcca gatgatcccg
     3781 ccgcgacggt cgcccgcgcc gtcctggcgg cgggtcttgc ccgtatggag ccgcttgatc
     3841 gccttctcga ccgcgcggaa ctgttgataa cgcggcgcga ccttgacgat cttgccctgg
     3901 ttggtcgtca tcacggtcac gtagttgtgg acgatgttga gaaggttcgc tgggtccagc
     3961 acgccggcgg ccaggatttc ttggcggctc agctgtgcgg cgcttttgcc ccgcagggat
     4021 gcgagttcct cctgggttag cgggtacggg tcccgccacg gaatgtagcg atcagcttcg
     4081 gcggtgaacg tgcccagtcg agcgtcttcc ccgctcgtcg ccacagtcag ctgcacggtg
     4141 tggaacagct tctgattgcc gacgcggtac tcactgttca cctgttcggc gtacctgcgg
     4201 atctggccaa tggccacatt taggctggtt tcggtcgtct tcttgcactc cacgacgaca
     4261 aggggtatgc cgttcacgaa caacacgagg tcgggcacga tcggcccccg cccgccggga
     4321 atgtccacac ggaactggtt gactaccgtg aactcgttgt tggccaggtg gtgccagtcg
     4381 atgaagtgga tcgtccgggt cttgccgccc tcccaccctt cgacaccctc gaccgcgacg
     4441 cccctgagca gcagttctgt ggcggctcga ttgatgtcga gcaggcttgc gggggctgtc
     4501 cgggtgagac cgttgatggc caggctgatt cggtcctctg tgagccactc ttcgcccagc
     4561 ggattcttgt tgatccgccg cagcgcggcg cgcagcttgt cctccagaat cacctcgtcg
     4621 aaactgaccc gtccggaggc agcgggtacg gtcgggatga cctcgtcgtg cgcagcgcct
     4681 tcgagatgcc gccagcccat ctgctggagt tgctcgataa gtggcttctc caccagggaa
     4741 tactccagcc cacctgccac gaaaccgctc cgtcccagcc gtcggcgtac cttgacgagc
     4801 atatctactc tggccgacaa gctgtgaagc gcggagaggc tagacgtcct ccagccgggc
     4861 accggcttcg gcgacccgta tccgcccggt cagcaggtcc tcagtaaggc cgtgccgcag
     4921 aaggatcagc tgatgcaggc gggccccttc ggtactggtg cttgtcttct gggccgccag
     4981 cagcgacagc aactcgtgct gcgcctcaag cggagggatc ggaaccggca tcgccttcag
     5041 ctggcgactg ttgatcgtgg ctaggttcgt tgtctgcttg gcgatgctga ggaagtactg
     5101 cttgccctgg ttcgaggacg tgtacgccgc aaggtaggcg ggtagcaatc tggacctgtc
     5161 gcagcgcaca cgaaagatat ggttctggca gatgcatgga tcgatccggg catcccacac
     5221 ggcaccgcga ccgagcttgt cgaagtcgcc gccttcggtg aggagcacgt cgccagctcg
     5281 cagcatatac cgttgcgcat cgctcttgct gacccgtacc gacttcacct cggtcgtgtc
     5341 gatgtagccg tcctggacgt tcgctaccct caagtatggc acttcaactg ttccgccggt
     5401 ttccgttccc aatgtgacgc cagtggcaac ggtcgcgacg cttccgagac tagcggtgga
     5461 cgcggcgagg cccgtgattc gccgaagctc tgcttcgatc aaagcggcgg tgatgtgaga
     5521 agtcttttcg acaacaagcc gctggttggc gatctgatcc tctatggtgt cgagaatctc
     5581 cacgatccgg cgttgatcct gctgtggcgg aagagccacc tcaatgcggc tgaagtcgcg
     5641 gtaccgaacg gcgccgcgcc tgtccaccga cgcttgctcg tgtactccgt acttcgcgat
     5701 caggtccggg gacttcagaa ctcggaacag atatggcgga tacacctcat cagtgcacga
     5761 gaagaccgtg tagatggggc tgacacaggc gagctcgaag tcctgttgca ggccgattga
     5821 cccttcagcc aggtggttcg tcgcatacgc gaaccagcca cggcggacca ccctgtatcc
     5881 ggacagattg ctgctgtaga cggatcggtt tttgaaatac tcatctgatg gaaccaggcc
     5941 gaggtgcttc gtggatgaca gcaccgtaac gccgcgccgg ccgccgacgc gctcggcctc
     6001 ctccagcgtg atgtcactca gtgtgaaccg cctccaacca ccgggcacgc taggcatagc
     6061 cgagctcctt gaggtaggtc tccagtcgag ccgctgccgc ttcacgctgg gcctccagct
     6121 cacgcaacgt gaccgcgtac ttgtcggccc atgtacggaa cgcggcttcg aggagccggc
     6181 gggcgccggc cacgcgtgag tcgaggcgcg aggcgagctg ctggcgaagc acctccagta
     6241 cgagggcgcg acgttcatcg gggctcaggg cagcggcggt cgtccgcagc cgcgggagaa
     6301 agtcgttcgc cagcgccgta acgtctttcc gcgccgcagc cgtgtcggcc ttcagccttc
     6361 ttagctcggc ctcagtcagc tggttctccg ggtcctgagc ctcgtcgtct tcctcgtccg
     6421 accgggcagt cgccgctctg agctgagcgt tcaggtcggc gtaccgggct tcggcctcgt
     6481 caagctcggc caaatagtcc gggatcaggg ccggaacgac acggtggtcg cgggccttgc
     6541 gcttctcggc ctcgatcttc tgtttgtccc agtattccaa ctcctcctcg tcgagctcga
     6601 acgccgactc gatcgttgtg agccaccctt cgaccacgcc ctcgaaaccg ttgagcgcta
     6661 gcgtcttcat gtcgtactga gtttcccccc accacgccgc gaccacccca gctagttcaa
     6721 agcggtcgag taagcccagc ggcttcagct cgccgacaaa cgagtcgagg agctccgcgc
     6781 ggatctccat gaccatccgg gagtcaggca attcgaccag ccgcttactg tgttgcgtcc
     6841 accagtcagt gaagacgtcc cgcaaccgtg tctccgcggg gcgggcgagt gccgggagac
     6901 gtttggcggt cgactcccaa ccctccggca ggaagtcgaa atagtgcgca tctctatcgg
     6961 cgagtaggct tgccggatcg atgccaaacg cggtgaacag gtgagactta ctggcaacct
     7021 cggtcttggg cacaccaccg tgcacatgag cgcgcacgtc ctgcggctcc ggcgggggcg
     7081 tattgtcgac atacctgcgg atgttgaggt tgaagtcgtt attccttagt tccttgacat
     7141 cgacgacacg agcaaagccg ggtatatcgc ggtgctcctc gaacgctgat acgatcttct
     7201 ccgcgtgctg cggctcaagg taattctgcg cgcgaccgct ggtgaattcg cggtcggcgt
     7261 tgatgaagag taccttaccc tgtcgatcct tgcgccgttt tgccgtcccg cgcagtacga
     7321 ggatgcaggc gggaatgcca gtcccataga acagatttgg gggcaggccg atgaccgcct
     7381 ccaggcggtc atcgttgata atgccctcac ggatcttttt ctcccggcca ccgcgaaaca
     7441 acacaccatg cgggagcacg gtcgctccga cgccgtcggg ggtaagcacg gcgagcacgt
     7501 gctgggcaaa catgaggtcg gccttcttgc ccgtttccgg tgcaaagccg tacttgaatc
     7561 gctccgggtg ccgcatgtca gttgcgacat agttctggga gaacggcgga ttggtcaaaa
     7621 ctcgatcgaa gcgcatcagc tcgtcgccct cgtggtgtag agggttggct agcgtgtcgt
     7681 cgttttccag gctggcgttg agcacaccgt gcaagatcat gttcatcttg gagatggccc
     7741 aggtcccacc gttgtactct tggccggcga gagttaggtc gcggtgatcc ttgccatgct
     7801 cctcgacata ctccttggcg tgaatgagca tcccgccgga gcctgcacaa ggatcgtaga
     7861 tgcgcatgcc aggctccggt ttgacgagcc tgaccatcat gcgcaccaca ccccgcggcg
     7921 tgtagaactc accgcccttc tttccagcgg agtcggcgaa ctcagcaatc agatactcgt
     7981 acgccgcacc cagcaggtca gggaactcga agtcttcgtt acgcaggcgc acccgatgga
     8041 aatggtcaat caacctctgc agccgccgat cggggatggt cgactggccc acctttttca
     8101 tgaagtcgat gtgctcgagg acgccctcca gtgctgccga gttgacctcc cccagcgagc
     8161 taagcgccgt gttgagcaat tccccgacat tctttcgccg agagttgtcc ttgatatact
     8221 gccagcgagc gtccaagggg acataaaaac tctcgcccct atagaagtta ggggcgtcgg
     8281 ccatccgctc agcctcgtcc ggacttttac cctgcgcctt ccactttctc accaactgct
     8341 cacggaccac gtcgaactgg tcggaggcac gtttcaggaa cagcatcccg aagatgtatt
     8401 ccttgaactc ggaggcatcc atcttgccgc gcaagatatc cgcagccccg aaaaggtgcc
     8461 gttccagctg cggcaacgtc agcctagcca cgtggtgacc tctcgctcgc aggggcccgt
     8521 cggccatggg gtcgacccga ttgccgaatg gaccgtgccc ggcggggcgc ggcccaggtg
     8581 gcgatcatcg cgtctgccaa attatccctg ctcgcggcga tccatggaac ggcacccccg
     8641 accgtaaccc aaatgcccgg attgctacct acggggcaat tcccagtgcg ccggcgatgg
     8701 cggttgaaga tgaaggacgt gccacgtacc tgcacagagg caaccctgtc gacgtcgagt
     8761 ttacgcttga gggagggcga agaacgcctc ggccagggct ttgtcgtaac atgagccaat
     8821 ccgctccatc gagcggcgga cgccgtggcg gcgaccggca tcagcgaagg cgccgccgct
     8881 gtattgggcg gtaccgcgcg ggcgtcccga tcggtggagc cgggttgccc gtcggctggt
     8941 cagcgcttgc gagggcgcgc tatgaccgat tcggcgatgt cgagcgcgcg gagcagggtt
     9001 ctcaggtgcg ccgccggcag ggtgcctgcg tcaaagccgc atgctgatac gagcgtcttg
     9061 agctggctga ctcgttggta gggggcggcg gcgaggcagg tggggtgagt cagtagatcc
     9121 cgtgcggcgt atccgtcgtc agcagcgtac tgggtcagtt cgacggtgat ctgctcggcg
     9181 gctgggtgat ctttgtcgag ggcgtcgagg agggtgaggc cgagtcgggt gtggaagacg
     9241 atgagtccgg gcttgacggg cccgagtgcg tggtaggccg tcagcgccgt gctcgcctga
     9301 tcgtccccag agcatggcat gagcaggtgc aggcatgcgg tgacggcgtt ttcccatggt
     9361 tcgccgggtt tggtggcatc gaggatcgcg cgtgcctggc ggtggcggcc tgctatggcg
     9421 tgggcgatga cggtgatctg cctgccgtcg agcatgcgta cgccgacgcc gttgtactgg
     9481 gtgaggcggt ggctggcttc gtcccatcgc ccggaggtgg cgagggcgtg ggcgccggtg
     9541 ccgagcagga cggtccatag ccaggttcgt gtcttggtgt gggtgccgga tgcctcggtg
     9601 aggcgggcgg cggggatggt gaggccgtcg atcagggcgt cagtacgggt gtcgatggcc
     9661 tggaagaggg tttccagcag ggtccacgca gcaaggccgt cgcccgcgcg gatgcggaga
     9721 cgggcgaggt tcacgatggg ttcgagcgcg tgctggggat cgctgccgtg gtcgagtgcg
     9781 gcggtggcga gccgatggca ccaggtgcgg gccaggtcgg gcatgccgca gtcggaggcg
     9841 aggagcgcgg cgaggttgaa cgctgcggtc gcggcggcca cgtcaccgct ttgccgggcg
     9901 aggtcggcgc gtttctggag gtccgagacg cgctgggcca ggggtgtgca gacgggtcgg
     9961 gttcgggcga tcagcgggaa tctgcgggcg acggccgggt tcatgattta ccgcctgttg
    10021 tgtgagtgct gtgcgtgggg tcggggccga agatgatggt tttggcagcg gtagcgaggg
    10081 ccgcttggtg gaggccgggg atgccgcgcc ggttccaggt gaagatcacg tggtgtgcga
    10141 gggtggctcg caggccgcgg tgcaactgtc cggtctggtt gaggtgccgg agggtgtcac
    10201 cggcggaggt gtgagcctcg aacaaggtgt ggtagccggc cagcggcgct ccttggccac
    10261 gggtgaggct ggccgggtcc actgtgagga gccttcttgc ggcgttgagc agggagtcga
    10321 cgagcgctgg ttggggtggg tctcggtgtt cggcgacgcg tgcccatacg tcgccttgtt
    10381 cgtaccagtc aaggctcgcc gctcgcatca tggtggccga gagcatgatc gacagttcgc
    10441 gttggcggcc gggtgtgtgg tcggtgctgc gggtgagtag gtggcggctg tcgtggtgcc
    10501 agagccggtg ggcggtgtcc atggcttcgg tgccgccgaa ggcgtgggtt tcgggctcgt
    10561 agatgccggg gacggcggcg cggatgtgac gggcgtgctt gagccgctcc agctcgctgg
    10621 tcaggtagcg gtcggcgtcg gatgttgtgg cggggaggta gcgcagccgc cagttgtctt
    10681 tgcgtacgta gaaccaggtg gtgatgaggt ggcgggcttc ggcttcggcc aggatcggcg
    10741 cgagatgcgt cctggctgcc tgctctgccg tgtgtggatc aggaaaggcg atcgtggttt
    10801 gccgccattc gggtgccgtc atcagcgcgt tccctcgttt aggtgagggc gaggaaggcg
    10861 tcccagctgg tggccgaggt gccggtggcg gcggtgtgga gggcgagcgc ggctccggcg
    10921 gtgccgtcca tcaactctgc gctgcgttgg gtgtcggcgg cgagctggct ggcaagctcg
    10981 gcggcaaggc caggtagctc ggcggtgagc tgggctgagc gctgcgggtc ggtgctggtg
    11041 gcggctatgc ggcaggcgga ctggacgagg ccggctttgc cgtgacacag gccgatctcg
    11101 ggaagtcggt cgcgctgggt ggtgtcgcgt agtacggcga gcatcgcgtt ctccgcctgc
    11161 tgctgacggg cttcgtcgtg cagggcgagc ccgccgagct gctgggcacg agcgatgccg
    11221 ggggtgccat agcaccagga gggacggtgc cgccgtgggg tggtgtctgg ggtgacgtag
    11281 ccgggccacc agcttccggc cgggtcgtcg tggcggtggt ggtcggtcca gtcgcagagg
    11341 gcggcgaggg cgttgcgggc tgctggggtg tcgtggccgt ggaggatggc gtaggcgagc
    11401 agggcgatga cggcgctgat gccgtgggcc atgccgatgt tgccgtgacc gtgcgggaag
    11461 tcggggtcgg gtgtgccgcc gagcccggag ggcagccacc acggcggctg agcggcgttg
    11521 tcgccgacgg gttcggtgat gcgggtgagg tagctggcta ggtcgtggct gacggggtgg
    11581 tcggggtggg cgtgcaggtg gtagaggccg agcccggtca ggccgtggac gaggtcgaac
    11641 tcgtacatag tcaatggttc gcggcggtcg atgcgggcgt gggcggcggc cagcctttga
    11701 cgtgtgaggg tgatcgtggc gtcgttgagg ctggcgcggg ctcggtggta gccgccgagg
    11761 gggtgggcag tgtgcagcat gaacgccaac gcgggggcgc cgtggaaggg gtcggagttg
    11821 cggccgatgc tgaccggttc gttggctgcg gcgcgtatcc agtggtgggc ggtggcttcg
    11881 tcgccatgtc cggagacggc ccgctcgatg tgcagcaggg cgatgcccgc cgcgcctccg
    11941 gccagcgatt gcggccgggt ccgcccgtcg ggggacgggc cgacgatgga ggggctagcg
    12001 agtctggcgc ataccgcccc gagcaggtcc aagtggttgc cggtggtggt cggggtggtc
    12061 acgaggtgct ccttgtcgtc cagctcagcg cggcggcgcg ggcgaggtgc aggcaggctc
    12121 gttcgctgtc gaggtcgagt ccggcaacgc ggacgtggtg caggtgcagt aggtcgggca
    12181 gcagctcgac cggcgggacg gtgctgaccg tgggcaggct gtcgcgccag gcggccacga
    12241 tgcggcggcg ttcggcccag cggtccatca ggttctcgcc gccgggcagg gacgccacgg
    12301 cggtggggtc gtacggcttg gccaggcgga tggcctggtc gtagaccgct cgtgggggtg
    12361 ctggccggtg cgcgcgggtc cgggctatca gccatcgcag ggcatcgtgc gggtcgccga
    12421 tgaccgccgt gacgaggtcg accatgctcg cggcggtcaa cgcctgccag cccggggcgg
    12481 acgatcgcgc tgtgacggcc agctgggcga gcgcggctgc ggagtccgcc gcgaacaccg
    12541 ctgttgtcgc ctggtacgcg gccgggctgc cgaagcggcc aggctcgccg aagtcggtgt
    12601 cccactggac tcgccgggtc aggtcggcgt cggtcagctc tcgtgtccag ccggtgatgg
    12661 cgtcgatggg caagccgctg gtacgcagcc gcaggtgtgg ctccgggtcg gcgtggcgca
    12721 ggaaccacca cctgcccgcc ggtgggagtt gcccgacaag ccgaggcagg tgggcggtaa
    12781 ggatggtggt ctgttcctcc ggccgggcgt agatcttcag gtagtggtgg tcgctgccag
    12841 gcaggctgcc gtgggaacgg acatcgacca gggggctgct gaggcggggc ggtggtggtc
    12901 tcgcggtggt ggcagtcaac gggatgacga tctcgtgcgg atgcccgccg atccagccgt
    12961 cgccttcggg gatgagacgc aacagggcgg tcgggttgcg ggtcaggtgg tcgcgtagca
    13021 gcgcccggtg agcgggtcca tccaggtcga ggccgagggt ctgatcgccg accccgagcg
    13081 agactgcggt agggcagccg ctggcctccc gccaggcggt aagcgcttgg tcccactgct
    13141 gccagggggc tttccggtcg ggcagttcgg cggcgttcag gtgccaccgc gcggggctca
    13201 ggagggtccg gccgtaccgc agcgcgggca ggaacggcaa gcccttggcc gctggccccc
    13261 actccaccgg tgtgcacggg gtagcgaggg ctacgggcgc ttcggccagg aagcgggcga
    13321 atgggtgggc gtgccgtacc ggttcgaccg cgttcacggc gaccggctgc agcgcctgct
    13381 ggcgggagat cgacaccagg tataggcggt gcgcgtcggc ggttaccgcg atgtcgtcca
    13441 agccgatcgc ggcctccgac ggggcgtggt actcgccgac ggggatcaga tgtggcagca
    13501 cctggggggc gcggttgacg tccaggctga tggtgtagcg ggtgaccgca gaaagctggg
    13561 ccagcaacgc tccggcgctg actgtcgggc tgtcggtggc gcaggaggcc atccggtgcc
    13621 gctcggttgc gccgaacatg tccaggaacc ggccagcggt ggagaaggct tgcggagacg
    13681 cccgtacgac cgacagcagg aagtcgccgc cggcgatggc ctggagggag tcggcgtgga
    13741 cgcgcacggt gagctcggcg gtcggcggga tctcggtcgg tgccgggccg cccagcctct
    13801 ccagcagggc gtcgtcgagg acgacctcgt gttcccggcg cagggcggca cgttgcgcca
    13861 aggcgagcaa cccccgatcc ctatcggtca cggccgacgc gtcagctggt tcgccggtga
    13921 agccgtccgg gtagccgaga cccacctgaa catcgatcgc atccaggacg gggacgaggg
    13981 cgtgcaggcc ataccggtcc aagaaacgcg tatgccagtc ccgccaccga agcgatgtcg
    14041 gccgggcgag gcgggtcagc gcggcagcgg cccggcacgc ctcggccgtc accgtcgtcg
    14101 gcaccacaag gtcgcagtcc agccgcagat ccaccccgac cgcctgcccg ggattgatca
    14161 cggcggcggc cacgccgagt tcccggcggc gggcggcagc tgtggcctcg tccggtgcgc
    14221 ggtcgtgtcg ggccttgaga tcgcgaacgc gacgcagcgg atcaattagc tcgcccacgt
    14281 cgccgccttc ggctgcggca gtctccatct gtaccaccag atgcgtgagg gggtcggtct
    14341 cggtcgacgg cgggcgcagg ctggtcaaca gcaaccgctg cgtcaccatc tggccgatca
    14401 gccgctgcgc gccttcctgc ggcgccccac attcggccgt cagcttgccg atgaggtcgg
    14461 cccaccggat cggctcagcc gccaacgcga gagccgcgcg gatcatgtcg ttggccttga
    14521 tgcgcagatg cgtgggcgcg ccgtaggggt cactcgtggc ggcgcggtac tccagcacca
    14581 gcttctcact gcgctcgacc agcagattgt tggcgcgcac catcacatgc ggacgcagcc
    14641 gcacgtcgga ctccaggcca tccaggacgg cggccagcca gggtgcctgg aggcgagcga
    14701 cagggcgatg cgcggtgccc cagcggatgc gtccggtgcg gctcgcggtg gcgacgacga
    14761 cgcccgcgaa caacccgtac ggtgtggcac gggtggcagc gcgcagcagg tagcgcatga
    14821 ccgcgagcac cacccggcgg gcgttggcat gcgacaggcc gccgttgatg gcggcggtcg
    14881 cccgctcggc gaggtccggc gacgcgtggg ccaaggctgc cgcgaactcc ggaatcgtca
    14941 acgcctcggc aagccacagc cgccaactgg ccgccgtgtc gctgctggtc aggtcaggcc
    15001 atacgccgag ctgaccgggg cgaagtacgg ccgcccggag catcaaggca tcgttcacgc
    15061 tgcgatacac accagcctcc ccacggacgt gatcatctgt ctacgggtca ggagtgccca
    15121 accttcgaga gcaggtctcc ccgggccggg cactcctgac ccgatgtcga tggctcgtct
    15181 tgcggcctgc ccacctggtt cgggctggcc atcagagcga gccaccagcg gatgcggctg
    15241 gtcagcagct ggtgcaggcc gacgcgcagg tgctaccgca gttgtcctcg gtcatcttga
    15301 tgatgtgctc gacggtgcca ccggcctcga tgaactcgat gtcgagatcg aagtcgtcga
    15361 ggatgcagcc ctcgacgtcg ggctggaccg tggcgagctg ggccatgaca acctccctgg
    15421 ttggagtgat aggggtcccc gacgctcccc cggcatgggc cgctgaggtg agcgccgaag
    15481 tcttctagga ccaggcgatg gcgaggacgc cgtgtcgctt ggtgctgtgc cacccggtca
    15541 ggtcgctggt gtcggcggtg ttcgggtggt aggtgatgtg ggcagcgccg cgccggtagt
    15601 agcagtccgc ccaggtgcgg atcatggcga gcagctctgc accgacctgc tcggcttccg
    15661 gcccgtgggc gatgacaccg gtctcgtagc cgctgacggg ctgcggattc tcccgcttga
    15721 tgcgataggc gaagctgccg ccgcggacca gcgtcggggt gccgttgcgt accgtgcggt
    15781 tgactacgcc ctgatcgacc gcggcctgcg cggcgtgcag catcggcagt tccggcccgc
    15841 tggtcagcag gtacagctcc agctcgtccg gcatgtcgaa cggcgtgccc gaccagctct
    15901 ccacgggctt ggtgtggagc gccttgcgca gcgccggcac gtcgaacgtg agagcgctgt
    15961 tctgatcgag gcgcagcccg acgtcggggg tgaccgggat cagctgctcg ctggcggcgc
    16021 cgtcgccctg catcggcacg aacgagccga gccggtagtt gctggccgtc agcaccgacc
    16081 tgccgggggc gcggtcgaag gcgaccaggc gggtgatccc ggcgaaacgc agcggaacga
    16141 cgatccggcc gtccggggtg agctgatcga gccaggcggg cgggatgtcc cacgccccga
    16201 ccgtgaccat gatccggtca tactgcgcgt gctgtgccac gccgtgctcg gcgtcggcga
    16261 gcacgacgtt gacctgctcg tacccggccc ggcgtagacc tgcgcgggca cggtccacga
    16321 cgtcggcatc gatgtccacg gtcgtcaccg aaccggtcgg cccaacgacc tccgcgatca
    16381 gggcggcgtt gtatccgccc gagccgatct ccagcacgtt catgcccggc cgtacctcgg
    16441 ccagttctag ctggatggcc tgaatgtgcg aggccgagac cacgctggtc tgacgcccct
    16501 gagcgtcgat cttgggcacc agggtgctgt tggtctgata caccttctcc agcggttcgc
    16561 cgggtgcgaa ctcgtgccgg ggcaccgcgt tcattgccgc ggcgacgctg tcggtggtga
    16621 tcagaccttc gtcgcgcagg gtgcccacca tggcctggcg caaggtggtg gcgtcgtcga
    16681 cctgcaatgt catgggaatc cttttcgggt agcgggggct ggcggacttg gcgtcccgct
    16741 tcgccctatg gttttgggcg gctgggttgt tgcaacatgg cccagcgagg ctggcccgag
    16801 gccagagtca actgctcgtg ggccaggaga tcgtcaccac gccgtgggtc ttgttcatga
    16861 ccgtggcgtc ggcgcgaatc tgggagcggt cgccgccggc gggccagtag gcgaacgtcg
    16921 gaggcgtgtg ccgcccggct cggtcccacg cctggatctg ttcgatcaac gcggtggcgg
    16981 ccacctgccc gtcgcgtccg taggcgcggg caccgaactc cgccccggcg ccctgcatcg
    17041 cgtcccgcaa cacgaggcag gcgagcccgg ctccgcgtac gaccgcgaac ggcaaccagc
    17101 gcttccgggc agccagggcg ctgccctcgt cggcggcgag gcggcagaac ccatccaggt
    17161 aacacgcgag ccacaggtgc aggtcggcga aggagatccc gtggctgacc gtgacgccag
    17221 accaccactc ggccgcgccg gcgttcagca cgccatcgag ctgaatcaga tccgggggtg
    17281 cgccggagtc gaacgaaagc ttgaccttgc cgccggtggt atcggctagc tcgagcacct
    17341 ggttggcgtg gctgccggcg ccctgcatcg gcacgaaccc ggccacttcg gccgacgtgc
    17401 tgatcagctg gtcgccgtcg cgccggaacc cgatggtgcg ggtgaccccg ttcatgatca
    17461 gcggcagaac gagcacgcca tccggagcca gttggccaag ccaggccggg gcgatgtccc
    17521 acgccccgac cgtcacgatg atcgcgtcga acggcccctc gttcggcaca ccgtgctcgg
    17581 cgtcggcgac caggacacgg actcggctgc tgtagccggt ggcgtccagc gcggtcgcgg
    17641 cccggtcgat gacctccggg tcaatgtcga tgctcaccac gcggccctcc ggcccgacga
    17701 tctcggcgat gtaggccgca ttcagcccgc ccgagccgac ctccagcacc gtcatgccag
    17761 gtcgcagctc ggccagttcc agcatccgcg cctggatgta cgccgcggac accgacgaga
    17821 tcgccatgcc gtgctgatcg cgcttggtca ccactgagtt gtcgtaggca taggcgacct
    17881 caagcggtgt accggccggc atgaaccgct cccgcggcac cacgcggacc gccgcctcca
    17941 cgagagccct cgtgaccatc ccctcatcgc gcagtgtgtc caccagcgcg gcgcgcagct
    18001 gggcggcgcg gtcggcattg atgcgtggct cagccatctg ggtcactcat acttccttct
    18061 catcgggtcg gacaggcact ccctgcattc ggggcacgcc tggtgcggcg aatgcaggaa
    18121 gacagggcgc cggcgggagc cctgcgctag ttcctgcgat gtcaccgacg cctaacgaca
    18181 ggagtggttc gtcgtacaaa tcgccgccga gccgctgtag taccgcgagt tgttctgagg
    18241 ggagggggcg tgcggtcacg gcggacctcc tatcagggcg aggcgggcgg tcaggcgtcc
    18301 tggtgctggt ggccgttgat ggcgcactcg cgccagatgc gggacaggtg ccgggtcatg
    18361 tgggcggtgg cggggtggcc ggggtgctcg cgccggtggg tggtgatggt gtcggcgagg
    18421 agggtgcggg cggcttggca gtggccgagg gcgtgcagga tgagggcggt ggctgcttgg
    18481 acggcgaggg tttgctgggc gtgcgggccg tcggatttgg tgaggtggcc ggtgagttcc
    18541 cggtagaggt ggtaggcgcg ctgatggtgt ccgccgcgcg agtgggcagc ggcgaggacg
    18601 tggagggcgt gcaaggcccg ccggtgggtg ggcccgtgga ggtgggccgt gctggcccgg
    18661 gcgtaggtgg cccagctcat ggcgtcggcg gggtggccga ggcggagttg cagttcggcc
    18721 aacaggatgg cggcttccgc gtgcaccgcg tcggcgggcg cggtggcggg gtcgacgccg
    18781 gtgaggctgt cgtgcaggag ttgccgggcg cgcagcggat cgctgaggac caggttgcgg
    18841 gcggtggcga cacgctgtgc gcgttcggcc tcgaaccggc cgggttcggg agcaggggtg
    18901 gcgcgccagg tgagggtgac gtcgctgggg gtggcaccga cggtgatgcg ggcgaggacg
    18961 cggtgagcgt ggacggctgc gaggtgtggc ggggtcggcg tgctggccga cgggatgatc
    19021 cgagcggcgc gtgccaggat cgcgcgaccg acggtgtcgg cgacggccac gctatccagg
    19081 ggccggggtc tgcaaccctg ctggcactgg tagccctgcc cagagtcgtg cgactcggcg
    19141 tgggccatcg gctgctggca gaacctgcag tgcagcagtc tcggcggcag gtacatctcg
    19201 taggtgtcgg cggccggccg gtatggctgg ggcgggactg gggcggtggc tctggtgacc
    19261 cacttctgga ccaggcgcgg gtcgaggttc atctgacggg cgacggcggt gacggcgccg
    19321 tatgccctga ctcggcgggc atccgtgacg cgctgcacga cggcgtcgat caggtctgga
    19381 ggatatctgc ttggaaaggc catgattcgc ggaatcagct tcaggttggg ggtggtcagc
    19441 tgcctgtgga tgtcaccggt ggggctgttt gtgacgggag cgctggcgct aggcatggaa
    19501 gccgtgccag cggttgtcga ccgggcgggc cgggttgatc ggcatgacgc tgctgccgtg
    19561 gcgagcgttg cggcgcatcg gctgcaaggt cgggccgtcc ggcagggtga tcgccggtcg
    19621 gggtgtgtag ccgtatcggg cgagcaggtg ctccccgccc gcaaggaccg cagtccagga
    19681 cggcaggtcg atacggtcga ggcggcttcg gtggtgggcc agcagcgcga cgccacagcc
    19741 gccccgttgg acgtcggtgc ggacggcgag gaacgccagg tggtagtgcg gttcggtggg
    19801 ctgtttcttg gcaaggagcg tgtccagcag gtcgaagcgg tcggcgtgtg gtcccgcggc
    19861 gtcggtgagc cgggtccggt agttggccgg cggtgggatg ggtcggtagc ggtggaagcc
    19921 gacggcggtg gcggtcaggt cgtcggtgag gtggatgtcg ccgaagaaca gggcgtgctc
    19981 cacccagatc gccacgacct cggtcagcac ctggcacctc tgccctggtt tgggcaccag
    20041 ccacgcggcg agcggtgtgg ggtgcagggc gtcggcgatc agcagggcaa ccagatcctt
    20101 gtctgcccaa cgggcagcgc gaatgtgcac caggctctcc atcggattag atgtccttgt
    20161 ggtctcgctt caccggtacg gtgcggtggc gaggtcaccg acggcggcgt cgagggcggc
    20221 ggtgatgtcc cgcaccgacc ggtggtgctg gccggcgacg gccttcaggt atgccgtcac
    20281 ggtcgtactg tcgtcgttga ggtagaggtg gccggtgagg ccgagggtgg cgacgagtcc
    20341 ggcgagtgcg gcggtgtggt tgtcgggctg ctcacggcct tgagcgacgt accgcaggcg
    20401 tgcgcgggcg acgaccgccc acttggtgtc ggtggcgagg taggtgtcgg tgcgggcaag
    20461 gccgccgagg cgccggcgag tgacctgccg gaggatcccg gcggcgacga gtccggcgcg
    20521 agtgcgctcg tataggtcgt cggcgaagcc gcgcaggaac gccttcaccg gtggtgctgc
    20581 acgcccacag cggataaagc cgatggcact gtccgcgatt aggtctccga gcggttgatc
    20641 ggtgtgcagc cgcagccacc gatctccgga caaacggtcg tcgttcgggt cgaggacgat
    20701 ccgcccggcg agaaacaggt cgatcaggac cgcgccggcc agccccaacg ccaaggcttg
    20761 gcggtggata tgcgggtggc cggcgtcgtc gtcatgaccg agcaggaaca actcatcgcg
    20821 tagcgacagc cgagcaaaac tcatcggcct accccttccg gggtctggac gcagcctgcc
    20881 gcaggctggc gcgcaacctg ggcggacgcc cacttgccgc cttcggtggg tcccccggat
    20941 ccgatgaaca tcagtaccca gctggcagtg ggcagggatg gtcccctgcg ggtagcgagc
    21001 cgaggaggtt cactcacgag ctgctgctcc tttcatcccg accccggcta ggaagccggt
    21061 gaggaagggg ctggctgacc cgtgtcccct ctcgatctgg tcctcgggat cagggcgcca
    21121 ccgagcaaca gggacgagcg ctgcgttgct cgccgacttc gctgctggcg cgtgggcagg
    21181 gaccatggcg aagtcgccga atagcgcctc gacctctgcg ggggcgcgca gttgaagtgg
    21241 ggtaggcgtg cgctgataca gcctctgcac ctcatcggtc tggcttgtgg ccgtgccgga
    21301 ggtcgcgtgg gagatgacga gggcgctgcc agggggcatc gcggcgcgga acggttccac
    21361 gatggcgttg acgtcgccgg ggatgaagtg caggaccgag acgaagagaa cggcgacggg
    21421 acgggtgagg tcgatcagcc gctgcgtggt ggggttctgg aggatgaaat ccggaaagca
    21481 gatgtcggcc tggatgacat cggcccgcgg atcattgccc agcagtgctc tagcgtgcgc
    21541 cacggctacc ggctcgacat cgacgtaaag aacccgcgca ttgatgtcgt cgtggcgggt
    21601 gatgtcgtgg acgttgccca cggtcggtat ccccgaaccg aggtcgagga actggtgtat
    21661 gccctgctgg agtgcgtagc ggacggcgcg gcgcaggaac gcgcggttgg cgcgggccgc
    21721 gtcggcgaca tggggtgcga cggcgagtac ggcatcggcg gcgtgacggt ccgcggcgaa
    21781 gttgtggctg ccaccgagga agtagtcgta catccgtgcg gcattcggac gagtcaggtc
    21841 gacctcggcg ggtgcccagc tcatcgcctc agttcccatg gtctttcccc ggttgctcgc
    21901 ttggggcctc ggcgatgcgg cgcagccgct ggtgcactcc gtcgtagggg ttcacgcctg
    21961 ccaagatcgc cttgttgagg gcggcgtgca tggtgtagag cgggtcgcaa acgtttccgg
    22021 gtgcggctcg gccggcctgc gagacgacct ggtaggcgtc gagcagctcc aagccggtca
    22081 gttgtgcggt ccaggtgacc agatcgtgct ggctgatccg gtacgcgtct tctaggggcc
    22141 gggcggcacc gaccgagatg atccggtggt cggtctcgat gcgcggccat ggtgtggcca
    22201 cgcccttgat caggtcgaca gcaacggtga cgttcatggc tgtctccacc gcgacgccgc
    22261 acacctcgcc ctggccttgg cgggcgtggc cgtcgccgat ggcgaacagc gcgccggggg
    22321 cgttgacgcc gatgtacacg gtggtgccgg ggcggatctc tggagtgtcg aggttcccgc
    22381 cgtgcgcatc aggtacgacc gtggagcggg cttccccgcc ggccggggcc agtcccacgg
    22441 tgccgagcat cggctccagg ggcatgacga tcgcatggcc ggagcggcgg gcgtggaagg
    22501 tcaccgtgcc tgccgcggtg tcgatggtgt agcgccacac ccgctcctcg agcggtgggt
    22561 gcagcatcgg cgtggtgtgg gtcgcggtca gtgccccgaa gtgcgggaag gttgctgaca
    22621 tgccccagtc gcgggccggg gtgatggcag cgaagtgtag cccgagggtg tcgccaggtt
    22681 ctgcgccgag cacgtggaag gggccggtga cgggattaaa tgcttggcac accttcgacg
    22741 gcaggtcgtc tacggtgcgc acggccccgc cgaagcagtc ctcagtactg gtgacaagca
    22801 ggctgcccgg cttgatctcg gcgaccgccg ggtgggcgcc gaaggtgtaa cgcagctcgt
    22861 cttcggttgg ctggtaggtg accgtgctgg tcatgccgcc tcccgtccgc tggcaagtcc
    22921 ggacagctcg gggcggcggc cggcggcgta cagacctgcc agggccagga ggccgagggt
    22981 gagccagacg aagccgaggc gttgggcggc cacgttggcg ttgaccacga cgtaggcgag
    23041 gatggcgaat ccgatgcccg gaaggatcag gtgtgcgatc aggttgcggc tgcgtcggcg
    23101 gaccaggtag tgccagatga cggcgaggtg cagcacgagg aacgcggtca tcgcgccgaa
    23161 gttgatcagg ctggacagca gtgcgatgcc atcgtcgcgc cagttcatgt agaggccgat
    23221 cgtcagcgac accagcgcag tgagggtgat ggcgtgggtg ggcacgctgt ggcgcaccga
    23281 caccttggcc aggaacttcg gcagctgccg gtcgcgggcc atggcgtaca gcagccgcga
    23341 ggtggcgacc tgcgcgacaa gggagttcgc cacgccccag gcgacggccg tggcgaccgc
    23401 gcacagggtg gccagccagg gaccaccggc gagccgggcg gcgtcgtaga acgcggtgcc
    23461 ttccggatcg ccattgacga ggaggccatc cgggttgggc agcagcagcg cggccatcca
    23521 ggtctgggcg atgaacagca atccggccac acccaacgcc gcgcccatgg cccggccgat
    23581 ctgccccgcg ccgcccttgt tctcctcggc cagcatcgag atgccgtcga agccgaggaa
    23641 gctgagcacg gcgatcgaca ccgcgccgaa caccagcgcc caggtgaacg tgtcggggtt
    23701 gtagagcggc gtccaggaga agccctgtcc cttgccttgc gcgagggcgc ggcccgcggc
    23761 ggcaaggaag atcaccagga cgatgacctc gccgacgagc atcactcggg tgatcagggc
    23821 ggtcatccgg attccccggt agttgaccag ggtgtttatc agcacgaagc cgaccagcca
    23881 gacccacact ggaaccgccg gcacggtgga gtgcatcgcc accgcggcga tcaggtacag
    23941 caggctcggc accagcacgt agtccagcag gatcgcccag ccagcgagga acccgaccgg
    24001 tgcgccgatc cctcgcccgg cgtagttgta cacactcccg gcaaggggaa acgccttgac
    24061 catctgggcg tatgaggcgg cagtgaacac cagcgctgcc atgccgatga cgtacgccag
    24121 cgcgaccatc ccgccggcgc cggagtagac ggatccgaag atgcccatag gcgcgatcgg
    24181 caccatgaac accagcccgt agaagagcag gtcggcgaag ccgagtgagc ggcgcagctc
    24241 cggtcggtat ccgaaccgcg aggagtcggg cgacgcctgc gccaagccga tctccggcgg
    24301 aggcgctatc tgcctagtgt gcatgctgtt tcattccttc ctgtcggtca gcgacgccag
    24361 ctcacttccg ccagtgctcg agctggccaa gcggcggcag cggcttcgaa ggcagacgca
    24421 tcgtcgggag ctgctgaatc ggttgctaga ggggccagat catggacagg tcctgggcac
    24481 agccgccgag ggcgaaagac aagcggcgga cgatgggccg agttcctcgg gcgcgccgtc
    24541 cgccaccaaa cccggtgccg gcgtcgccgg ctccagaacg aactgttcga ggtcctcggc
    24601 atccacggcc gttcagctgg caaccgcaga gcccccggta ggcccgctga ccgagcaccc
    24661 cgaacgggct gcagcgacgc accgcaacca cgccagcgcg gcagaccctc gagggtgaag
    24721 acccccgaga caggcgagcc gggctgcgcc agccactcac taccgcggtc ggaagcggca
    24781 tagcgagcgc gtcacgcacg ctgtcgcttc gcacgtcgac gaccacgagg acacctccac
    24841 catcaccgct gctcgcaaac gcgagggctg ccacagcagt ggaggtagcg cgaagtcgca
    24901 gcgcccatcc atcgccgtgg ttgtctgtgc gaccagcctg cgggttcggc ctgtcccatg
    24961 acgatgcgtg gacgttctag tgttgtccta gtttcagctc gtctgcgccc gccgtcgtct
    25021 actacgctgc cgactgcgac aatgacgctc agtgcatagc ctgggggata
//
