LOCUS       NZ_CP118233            22616 bp    DNA     circular CON 13-JUL-2024
DEFINITION  Micromonospora chalcea strain 1K05785M01 chromosome, complete
            genome.
ACCESSION   NZ_CP118233
VERSION     NZ_CP118233.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora chalcea
  ORGANISM  Micromonospora chalcea
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Study on the Growth Characteristics and Drug Resistance Related
            Proteins of Micromonospora chalcea MCCC 1K05785
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6861996)
  AUTHORS   Yu,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-FEB-2023) Tianjin University, Tianjin University,
            Weijinlu Nub92, Tianjin, Tianjin 300072, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: MAY-2022
            Assembly Method                   :: CLC NGS Cell v. 5.29
            Assembly Name                     :: TJU-micro-1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028768405.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 23:01:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,224
            CDSs (total)                      :: 6,161
            Genes (coding)                    :: 6,110
            CDSs (with protein)               :: 6,110
            Genes (RNA)                       :: 63
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 16 of 51
            Pseudo Genes (incomplete)         :: 40 of 51
            Pseudo Genes (internal stop)      :: 2 of 51
            Pseudo Genes (multiple problems)  :: 7 of 51
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:37:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1330325
            Orig. end                         :: 1352941
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP118233.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22616
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="7"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22616
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22616
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12616](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12616
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    38..49
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    203..217
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.06"
                     /tool="antismash"
     gene            277..1005
                     /db_xref="GeneID:91355725"
                     /locus_tag="PVK74_RS06200"
                     /old_locus_tag="PVK74_06200"
     CDS             277..1005
                     /NRPS_PKS="Domain: PKS_KR (3-161). E-value: 2.3e-15. Score:
                     48.9. Matches aSDomain:
                     nrpspksdomains_PVK74_RS06200_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GeneID:91355725"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018255858.1"
                     /locus_tag="PVK74_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06200"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_069089648.1"
                     /sec_met_domain="adh_short (E-value: 2e-37, bitscore:
                     127.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 4.7e-31, bitscore:
                     107.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVTIVTGGGRGIGAATARRLAAEGHDLVIGYRADHTAAESVAA
                     DVRAAGRRAVTVAADTTDPDQVRRIFDAADRLGPLTGLVNNAGVTSPIGPFTDLRVDDL
                     REVVDVNLIGYVLCAQQAARRLTRGGAIVNVSSVAATLGSPGEYVHYAAVKAATDTLTV
                     GLAKELAPHGIRVNAVAPGIIRTTIHARSGVPDRPDSAAGRIPMGRAGEPEEVAGAIAH
                     LLGPDASYTTGAVLRVGGGL"
     aSDomain        286..759
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PVK74_RS06200_PKS_KR.1"
                     /evalue="2.30E-15"
                     /label="PVK74_RS06200_PKS_KR.1"
                     /locus_tag="PVK74_RS06200"
                     /protein_end="161"
                     /protein_start="3"
                     /score="48.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VTIVTGGGRGIGAATARRLAAEGHDLVIGYRADHTAAESVAADVR
                     AAGRRAVTVAADTTDPDQVRRIFDAADRLGPLTGLVNNAGVTSPIGPFTDLRVDDLREV
                     VDVNLIGYVLCAQQAARRLTRGGAIVNVSSVAATLGSPGEYVHYAAVKAATDTL"
     CDS_motif       292..354
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PVK74_RS06200_0001"
                     /evalue="2.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="PVK74_RS06200"
                     /protein_end="26"
                     /protein_start="5"
                     /score="17.0"
                     /tool="antismash"
                     /translation="IVTGGGRGIGAATARRLAAEG"
     gene            complement(1057..1182)
                     /db_xref="GeneID:91355726"
                     /locus_tag="PVK74_RS06205"
                     /old_locus_tag="PVK74_06205"
     CDS             complement(1057..1182)
                     /codon_start=1
                     /db_xref="GeneID:91355726"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PVK74_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PVK74_06205"
                     /product="hypothetical protein"
                     /protein_id="WP_255361250.1"
                     /transl_table=11
                     /translation="MNEHSGGGQRTRLVVSWLVVSVLLGYGVVQTVITAAKLFTQ"
     gene            complement(1179..2588)
                     /db_xref="GeneID:91355727"
                     /locus_tag="PVK74_RS06210"
                     /old_locus_tag="PVK74_06210"
     CDS             complement(1179..2588)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355727"
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286346.1"
                     /locus_tag="PVK74_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06210"
                     /product="OFA family MFS transporter"
                     /protein_id="WP_274478459.1"
                     /transl_table=11
                     /translation="MLSALDRRHTVAPPGYSRWLIPPAALAIHLCIGQVYATSVYKNSL
                     IAHFDTSQTAIGVIFSIAIVMLGLSAAVAGTWVEANGPRKAMFVSACFWAAGFLVGALG
                     IATGQLWLLYLGYGVLGGIGLGIGYISPVSTLIKWFPDRPGLATGLAIMGFGGGAMVAS
                     PLSRQLLSFYDAGYDPSDSGSTASGSALVWLFVTLGIGYFVIMMFGVFNVRVPAPHWRP
                     AGFDPSTVAKKPLVTTANVSAANALKTRSFWLLWVVLFCNVTAGIGILEQASPMIQDFF
                     RDNGTSAVSVAAAGGFVGVLSLFNMAGRFVWSSTSDVIGRKPIYVVYLGVGMVLYLLLA
                     LVGQTSTALFVLLASVILSFYGGGFATIPAYLRDLFGTFEVGAIHGRLLTAWSAAGVAG
                     PLIVNGFLDAQGEPGTLTAAAYRPALFTMVGVLAVGLVANLLVRPVPERYHEPASGRDG
                     TAQGPTERSGS"
     gene            2767..3618
                     /db_xref="GeneID:91355728"
                     /gene="pdxY"
                     /locus_tag="PVK74_RS06215"
                     /old_locus_tag="PVK74_06215"
     CDS             2767..3618
                     /EC_number="2.7.1.35"
                     /GO_function="GO:0008478 - pyridoxal kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009443 - pyridoxal 5'-phosphate salvage
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355728"
                     /gene="pdxY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019872348.1"
                     /locus_tag="PVK74_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06215"
                     /product="pyridoxal kinase PdxY"
                     /protein_id="WP_043324020.1"
                     /transl_table=11
                     /translation="MKILSIQSSVAYGHVGNSAAVFPLQRLRHEVWPVLTVHFSNHTGY
                     GAWRGPLLAPTDVADVIAGIADRGVLGTADAVLSGYQGDPAVGAVILDAVAQVKAANPA
                     ALYCCDPVMGDVGRGMFVRPGIPEYLRDTVVPRADIVTPNQFELEFLAGRTTDTLDDLL
                     AAVDTVRATGPRHVLVTSVLHGDLPAGHLEVVAVSDEGAWAVTTPLLPIAPNGGGDVTA
                     ALYLAHLATTGSPQTALERTTNSIYAVLEATLDAGTRELQLVAAQDAIAEPPTRFTARR
                     LR"
     misc_feature    2768..2782
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            3717..4181
                     /db_xref="GeneID:91355729"
                     /locus_tag="PVK74_RS06220"
                     /old_locus_tag="PVK74_06220"
     CDS             3717..4181
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355729"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286348.1"
                     /locus_tag="PVK74_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06220"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_113974130.1"
                     /transl_table=11
                     /translation="MSPHQGTDDPAFAQRLRDLTRLRRVRDRIDREYASPLDVEALARG
                     EHMSAGHLSRQFRQTYGESPYSYLMTRRIERAMALLRRGDLSVTDVCFAVGCQSLGTFS
                     TRFTELVGEPPSAYRARHAPDTAEPPPCLTKQVTRPIRNREARTGRPPLA"
     misc_feature    4173..4175
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4187..4600
                     /db_xref="GeneID:91355730"
                     /locus_tag="PVK74_RS06225"
                     /old_locus_tag="PVK74_06225"
     CDS             4187..4600
                     /codon_start=1
                     /db_xref="GeneID:91355730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574739.1"
                     /locus_tag="PVK74_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06225"
                     /product="VOC family protein"
                     /protein_id="WP_043330132.1"
                     /transl_table=11
                     /translation="MTITIHYTFLPHTDADAAIAFYRDTLGFELRNDVGQGDTMRWLTV
                     GPPNQPETGIVLHPPAVDPGISDDERRTILELIAKGSYGALTLATDDLDGLFDRLAASG
                     ADVVQEPTEQPYGVRDCAFRDPTGNLIRINERR"
     gene            4657..7032
                     /db_xref="GeneID:91355731"
                     /locus_tag="PVK74_RS06230"
                     /old_locus_tag="PVK74_06230"
     CDS             4657..7032
                     /codon_start=1
                     /db_xref="GeneID:91355731"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286351.1"
                     /locus_tag="PVK74_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06230"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_274478461.1"
                     /transl_table=11
                     /translation="MSEATTGLHRADSHDVIRVLGARENNLRDVHVELPKRRLTVFTGV
                     SGSGKSSLVFGTIAAESQRLINETYSAFVQGFMPTLSRPEVDVLEGLTTAIIVDQERMG
                     ADPRSTVGTATDVNAMLRILFSRLGDPHIGPPNAYSFNVPSVRAAGAITVDRGPGKTQT
                     RKGTFNRLGGMCPRCEGRGAVTDFDLTVLYDEKLSLNEGAITIPGYSMDGWYGRIFRSS
                     GLFDPDKPIRDYTKRELSDLLHKEPTKIKVDGINVTYTGLIPAISKSMLAKDVDAMQPH
                     IRAFVERAITFTTCPDCDGTRLAPEARSSKINGVSIADVCAMQISDLATWVRDLREPSV
                     APLLKALGDTLDSFVEIGLGYLSLDRPAGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEP
                     TIGLHPHDIARMNNLLLQLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTAGGTICYE
                     GTVAGLRASSTTTGRHLDDRATLKDKPRTPTGALPIRGARTHNLRDVDVDIPLGVLVVV
                     TGVAGSGKSSLIHGSLARRDDVVSVDQTAIRGSRRSNPATYTGLLDPIRKAFAKANGVK
                     PALFSANSEGACPTCNGAGVIYTDLGMMAGVASTCEDCEGKRFQPAVLDYHLGGRDISQ
                     VLAMSVDEAEIFFSDGEARTPAAHTILDRLADVGLGYLTLGQPLTTLSGGERQRLKLAT
                     RMGDKGGVYVLDEPTTGLHLADVAQLLGLLDRLVDAGKSVIVIEHHQAVMAHADWIIDL
                     GPGAGHDGGRIVFEGTPADLVAARSTLTGEHLADYVGA"
     gene            complement(7072..7779)
                     /db_xref="GeneID:91355732"
                     /locus_tag="PVK74_RS06235"
                     /old_locus_tag="PVK74_06235"
     CDS             complement(7072..7779)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355732"
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018784313.1"
                     /locus_tag="PVK74_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06235"
                     /product="response regulator transcription factor"
                     /protein_id="WP_043324014.1"
                     /transl_table=11
                     /translation="MIRVLLADDQPLVRAGLAMLLTNEPDIEVVAEADDGAQAVEVSRR
                     LRPDVVLMDVRMPGTDGLAATRLMADEQLIDDPQQPVRIIMLTTYHVDEAVHAALRAGA
                     SGFVLKDAAPAELVSAIRAVADGEAWLDPAVARRLLDDLAARPDPGLPTPVQMRRLTPR
                     EREVLVLMAYGMSNREIAEHLVLGDATVKTHVSRVLTKLGLRDRTHAVVAAYQCGLVEP
                     GTAPPARMAGLSR"
     gene            complement(7879..9138)
                     /db_xref="GeneID:91355733"
                     /locus_tag="PVK74_RS06240"
                     /old_locus_tag="PVK74_06240"
     CDS             complement(7879..9138)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355733"
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="PVK74_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06240"
                     /product="histidine kinase"
                     /protein_id="WP_069089646.1"
                     /transl_table=11
                     /translation="MTSVTGAVAPSAPARAARWWRHDLLLLPVLGLLDLFTASSVVIQS
                     EPVGPARQWLQVLAAVLSVGALWWRARAPVAVFAFECVHGVAMWFLLHDYRPWVGLIVA
                     LYTVAALRPLVVSAAAYAAACARSLLSAFDSFRVEPSAGARAGEFVVTALMFALIYAAA
                     WAAGSVVRRHRRRVAQLERERRVARAEAVALERRRIAAELHDVVSHSVTVMVLQAAGAA
                     RISASDPERTREALLHIQQAGQQAMAELRRLLAVMRAESGPVGDGEPGPQPRLDDIEVL
                     LTSMRCAGLTVTMSVSGSPRPLDPSIELAAYRTVQESLTNTLKHVGRRACATVHFGWQE
                     RVLLLRVDDDGSGREAGAAAGLSTGNGLASLAERLERVGGRLVAGPRAEGGFRVSATLP
                     VAQHGDLVAASGDGGAPAVG"
     gene            complement(9146..9715)
                     /db_xref="GeneID:91355734"
                     /locus_tag="PVK74_RS06245"
                     /old_locus_tag="PVK74_06245"
     CDS             complement(9146..9715)
                     /codon_start=1
                     /db_xref="GeneID:91355734"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PVK74_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PVK74_06245"
                     /product="hypothetical protein"
                     /protein_id="WP_158560005.1"
                     /transl_table=11
                     /translation="MRTEVQSPPVVVFLQAQRPAGWVTVARGVPLDGRRCLLRTVGAGR
                     ARSGDAVRLVGVAGGDARSLAVAEVSVLHRDEADLVMVSLAGATVPGGHGTDALAVRRV
                     LAMLADDADGRWRVAADAAADVVAPVVLVGAGRAGAPGRTAVPVTTHRVGAATPSPDGD
                     GGGDDDGSPLSWTCRLFGIGCPTENS"
     gene            10001..12616
                     /db_xref="GeneID:91355735"
                     /gene="lanKC"
                     /locus_tag="PVK74_RS06250"
                     /old_locus_tag="PVK74_06250"
     CDS             10001..12616
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355735"
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="PVK74_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06250"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_274478462.1"
                     /sec_met_domain="micKC (E-value: 4.6e-242, bitscore: 804.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.2e-13, bitscore: 49.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-16, bitscore:
                     58.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPGAFLIADPVHVDSPAYVADTASRFPLADQTPPDGWRVAEHG
                     GWIMWHPPQAQLPQQGWKVHVSVNLDDAADVLDLVRDHCVTHRVAFKFQRSRRLALVNN
                     EKYAHRAGSGKLAALYPADDTALRRVLDDLGARLAGYRGPYVLSDLRWHDGPLYLRYGG
                     FAELWCVDGDQPVPAVARPDGTLVPDRREPVFTVPDWAPVPDFVAEHIAAVAAVDAQTD
                     DEPPYRIEEALHHSNAGGVYRATDLRDGRTVVLREARPHAGLDGAGTDALTRLRREETM
                     LRRLAGLDCVPQLLDRLTWWEHQFLVEEHVDGDTLQHHLAMRHPLIHPDPTEQDLTDYT
                     TWALDVIDQVQAALAQIHARGVVFGDLHTANIMIRPDGRIVLVDFEQAYLTDEDFTPSL
                     GDPGFATPRIRRGTAVDTYALACLRLAVFVPLTPLAALSDDKFDDLLTIARRFPVPPGY
                     LDRIRDDLRTALHPPTPGRRRVTRHQWSADPRQLIESLAAGIRATATPHRTDRLFPGDP
                     GQFPHGGATLAHGAAGIIWALVNTGVDYPERDEHLDWLTRAAHRLPAAHLGLYDGLAGI
                     AALLDRTGRHDDADELLDRCRTGLHHRYGPGLHSGLAGIGLALLRPGRPAPDDALHIGD
                     RLARTLTGDTTQPVPEPTRPGLLHGWSGPATFLTRLHETTGDPAWLRAARTALRRDLQH
                     TVRDDNGNLHVRDGARRLFYLDEGSAGIAVAAHTLLRHGERQWLRDIVTTVRRTIDVEF
                     VLLPGLFHGRAGLLATAALLTDDPPRRATPHRPVGLVRDDAPHHVPAHLTRLAWHAYAL
                     DGHLAFPGDTLLRISTDLAAGGAGILSAMHAALHRTAVTLPFLDAPTHVAPTGHLLAAS
                     "
     gene            12946..14211
                     /db_xref="GeneID:91355736"
                     /locus_tag="PVK74_RS06255"
                     /old_locus_tag="PVK74_06255"
     CDS             12946..14211
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355736"
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="PVK74_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06255"
                     /product="MFS transporter"
                     /protein_id="WP_274478463.1"
                     /transl_table=11
                     /translation="MPPTGLRHNRDFLLITVARTASKLGTQVTAVATPLLVLLTTGSAT
                     DAGLVAFAEGIALVLVLLPAGLLADRRDRRILMLCCDAGALLAVTGVTVLALVGHAPVL
                     LIAVLAAATAGLGAALQPAAAAATRAVVPARDLRTATVFNETRNGVVHLAGPPLGGFLF
                     GLAPALPFLVDALSYAVSLVAVALLRGPLGRSATTPGESLPRQAVAGVRFLWRQPSLRF
                     TLLCGAVLNFAFAGVLLAIIVVPVRNGASGLSAGTVMACVGLGAVAGSLVASWLTARVP
                     TRWLILAVVWACAVLTAAMATTDNGLVLGALAGACVLVVPAANISMLTLQTLLTPGDLQ
                     GRANAATSFIALIVAPFGPALSGLLIDRVPAPVVFGSFAAIMLALAVGAAVAPAVRAMP
                     DLRAVEEAPEPGEAERRDPQPV"
     gene            14345..15067
                     /db_xref="GeneID:91355737"
                     /locus_tag="PVK74_RS06260"
                     /old_locus_tag="PVK74_06260"
     CDS             14345..15067
                     /codon_start=1
                     /db_xref="GeneID:91355737"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PVK74_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PVK74_06260"
                     /product="hypothetical protein"
                     /protein_id="WP_147265160.1"
                     /transl_table=11
                     /translation="MELRRSREKLWRGLTVFGVGVLPLLYHTSASTGRWILLGLWLVSA
                     GLFVAYQLRPFRFRIGADGLDLRVAGLNRLVAWAEIDAVVLDQPLPSRGRNQRAAKVLL
                     VPATAATIDRPLTGRSPVDGRPALKLLDLDQVRQPADDVADALARFGAGRFADVRQQAP
                     ELSDDADTPDTEALTLLADLTPRVQKALDSGQVSQRQAVKAEVDAALARLQAGGHQPRL
                     AALLKVMSDTLGEDVKPS"
     gene            15517..16512
                     /db_xref="GeneID:91355738"
                     /locus_tag="PVK74_RS06265"
                     /old_locus_tag="PVK74_06265"
     CDS             15517..16512
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355738"
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018784306.1"
                     /locus_tag="PVK74_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06265"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_274478464.1"
                     /transl_table=11
                     /translation="MHDKPDETVGALIEEFLTARATRKPSPHTLAAYRRDLTAVAELIA
                     ADGDATPLPLDRVAVSSLSPRVMRAAFARFAAPRAAASVHRAWSTWNSFFTFLVAEGVV
                     PGNPMPAVGRPRTPLPRPKPLRGEDTPEELLAAVARAEGRQRDPWPERDLAVLALALCA
                     GLRLSELLALRVSSVAGRDGERRVDVAGKGGRPRTVPIEDAVDRVLTGYLDSRRLRFGA
                     RSVRPDAAFLVDRQGEALRRGGLQYLVESCYRRAGIGDRVPRGARLHALRHTFATRLAE
                     DGASAAEIMRLLGHASLASSQTYIEVTAGQQRAAVAANRTNRALSGLLKR"
     misc_feature    complement(15546..15560)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            complement(16502..17524)
                     /db_xref="GeneID:91355739"
                     /locus_tag="PVK74_RS06270"
                     /old_locus_tag="PVK74_06270"
     CDS             complement(16502..17524)
                     /codon_start=1
                     /db_xref="GeneID:91355739"
                     /inference="COORDINATES: protein motif:HMM:NF025708.4"
                     /locus_tag="PVK74_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06270"
                     /product="beta family protein"
                     /protein_id="WP_274478465.1"
                     /transl_table=11
                     /translation="MAGYYPILKGRKAEFQAIDNLAGELAPHIVPIFEVVPDKGPIEDA
                     RKFIERVKRTLPPGMVVAVDVQHLPEPMTGTRRPLHDIAVDLEAWRISALPVVHLQDTT
                     QQLADVRSAAAMHGGGVVRVTASHAEPDVTEVDGRLSQVLAVIELRTEDCIVVLDAAEV
                     RSDQDLTKAEPLLRKHLAWTRRHHWKDVVVASGGMPPNLSQVPPHRATPLRRRDFELWQ
                     RLQQHGVQFADYCIAHPGTSGKGWGPAPNIRHTGRDTWWTYRTTRDGKGNIGIYDICKA
                     LVSADHWPAAGRHFSWGDEQIALRAAGHAGTGVATDWIAWGTSHHLAYVAAQLGLTTTA
                     "
     misc_feature    17552..17566
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(17709..17724)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.92"
                     /tool="antismash"
     gene            17750..18682
                     /db_xref="GeneID:91355740"
                     /locus_tag="PVK74_RS06275"
                     /old_locus_tag="PVK74_06275"
     CDS             17750..18682
                     /codon_start=1
                     /db_xref="GeneID:91355740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286355.1"
                     /locus_tag="PVK74_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06275"
                     /product="hypothetical protein"
                     /protein_id="WP_274479252.1"
                     /transl_table=11
                     /translation="MGLPDDAQLPPWSDVDVLLVRREPGAKVGKFVHRGVLLEVSTITW
                     AELGGPEDVLGSWVFAPMLRTDGVIADPSGRLGAVRERVAAAFADPVWVRARCAGVRRR
                     IEAGLRAVDAELPTAEQVLTWVFPTSLLAVWPAVAGLVDPTVRRRYVRAERVLSRFGFA
                     DRYPGLLDTLDGGGVGLGPARVRAHLAGLAVVFDEVARLPREGFAFGADLGAAGRPVVF
                     DGAVELIGAGRHREAMFWVLVTYARCHVVLGAVAPERERALRPAFQAVLADLGVASAAD
                     RRRRADGLLAALPGWQVVVDAVVAEAVAG"
     gene            18776..19642
                     /db_xref="GeneID:91355741"
                     /locus_tag="PVK74_RS06280"
                     /old_locus_tag="PVK74_06280"
     CDS             18776..19642
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476775.1"
                     /locus_tag="PVK74_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06280"
                     /product="tetrahydrofolate dehydrogenase/cyclohydrolase
                     catalytic domain-containing protein"
                     /protein_id="WP_064445951.1"
                     /transl_table=11
                     /translation="MSSARLLPGAPVAERVLSEVAASVAELRAAGVTPALATVLVGDDD
                     ASAGYIRIKQRQAAELGFVSPHVHLPASASQADLHAVLADFNADATVHGVLVQYPIPGH
                     LDYDRALAVLDPDKDVDGMHPVNMGRLALGLPGPLPCTPAGIEALLAFHGVPVAGREVV
                     ILGRGATLGRPLAMLLAQKRPTANAAVTVVHTGVADWPRYTRRAEILIAAAGVPGIVRP
                     EHVRPGAVVVGGGVRYEGRRLLPDVDESCAEVAGAITPRVGGVGPTTVAMLFRNAVDAA
                     RRQAGLG"
     gene            complement(19646..20425)
                     /db_xref="GeneID:91355742"
                     /locus_tag="PVK74_RS06285"
                     /old_locus_tag="PVK74_06285"
     CDS             complement(19646..20425)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018813262.1"
                     /locus_tag="PVK74_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06285"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_210882863.1"
                     /transl_table=11
                     /translation="MRLATFNLLHGRSLTDGLVDPDRLTAAVTALDADVLALQEVDRDQ
                     TRSGKLDLTALAARALHADHHRFAAAVVGTPGEQFRPLTHDDDGHGEPLYGIGLISRHP
                     VRSWQVTRLRAAPVRSPIYAPGPGGGLILLRDEPRVVLAAVLDTPHGPLTVAATHLSFV
                     PGWNVWQLRRVIRALRALPAPRILLGDLNLPAGPAAALTRWRPLARRPTYPAGQPRVQL
                     DHILADRHALDRLPPVTAVHTPLATISDHRPLVVDLG"
     gene            20600..21370
                     /db_xref="GeneID:91355743"
                     /locus_tag="PVK74_RS06290"
                     /old_locus_tag="PVK74_06290"
     CDS             20600..21370
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460321.1"
                     /locus_tag="PVK74_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06290"
                     /product="TSUP family transporter"
                     /protein_id="WP_176722890.1"
                     /transl_table=11
                     /translation="MDALSLTTLLTAALVAGWVDAVVGGGGLLLLPALLVAAPGVPVAT
                     ALGTNKLAAIFGTSTAAVTYARRTKLDWGVAGPAAGLAVLTAGLGAALAGAVPGGAYRP
                     VVLVVLVAVAVFVMARPSLGVVSSPRRTPGRVVVAVAVAGLGIALYDGLIGPGTGTFLV
                     LAFTAILGSDFVHASAMAKVVNAGTNLGALVVFGLTGHVWWALGAAMAVCNVVGAAVGA
                     RMALRRGAGFVRVVLLVVVLALVARLGYDQWLAG"
     gene            21355..22158
                     /db_xref="GeneID:91355744"
                     /locus_tag="PVK74_RS06295"
                     /old_locus_tag="PVK74_06295"
     CDS             21355..22158
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91355744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476772.1"
                     /locus_tag="PVK74_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PVK74_06295"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_274478466.1"
                     /transl_table=11
                     /translation="MVGGLIAVAVRAEHDRAVLAGLLGRDPVLHAYQLGDLDDFFWPYT
                     SWFRRGDQVVLLYHGVELPTLLAFAAPDRVPELAGLLAEAAPVLPARMWAHLSPGLEAV
                     VGRWFVVSEAAAHHRMALTDPGRLAAVPAVGEPLGPADAAELSGLYAVAYPGNWFDPRM
                     LDTGQYVGVRERGRLVAVAGVHVFSPRWRVAALGNVTTHPDVRGRGLGAGVVAALCARL
                     LTLVDHVTLNVRADNAAAVRLYERLGFSRVAGFTECALTSAAAAG"
     misc_feature    22401..22415
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
ORIGIN
        1 cggccgcagc tgcgcctcgt acaactgcgt caccggcgta cccgaacgca cctgcgcccc
       61 gaccaccgac ccggccgacg tgcccaccac cagctccgcc tcgtccaacc gcaggccgtg
      121 cccggccagc ccggccagca gacccagctc ccaggccacc ccggtgaccc cgccgccacc
      181 cagcaccaac gcgcgcccca tgtgacagtc ctctccaccc cggatggtcc cgcccacggt
      241 aacgtcgccc ccaccgcaag gcaggggaga agtgcattga cctccgtcac catcgtcacc
      301 gggggaggac gcggcatcgg cgcggccacc gcccggcggc tcgccgccga gggccacgac
      361 ctggtcatcg gctaccgcgc cgaccacacc gccgccgaat ccgtggccgc cgacgtgcgc
      421 gcggccggcc gccgcgcggt caccgtcgcc gccgacacca ccgacccgga ccaggtacgc
      481 cgcatcttcg acgccgccga ccggctcggc ccgctcaccg gcctggtcaa caacgccggc
      541 gtcaccagcc cgatcggccc gttcaccgac ctgcgcgtcg acgacctgcg cgaggtcgtc
      601 gacgtcaacc tcatcgggta cgtgctctgc gcccagcagg cggcccggcg gctcacccgc
      661 ggcggcgcca tcgtcaacgt ctcctccgtc gccgccacgc tcggctcacc cggcgagtac
      721 gtccactacg ccgccgtcaa ggccgccacc gacaccctca ccgtcgggct cgccaaggaa
      781 ctcgcgccgc acggcatccg cgtcaacgcc gtcgctcccg gcatcatccg caccaccatc
      841 cacgcccgct ccggcgtgcc cgaccgcccc gactccgccg ccgggcggat cccgatgggc
      901 cgcgccgggg aacccgagga ggtcgccggc gcgatcgccc acctgctcgg cccggacgcc
      961 tcgtacacca cgggcgcggt cctgcgcgtc ggcggcgggc tctgacacga cggcggcccg
     1021 gggtgtccgc cccgggccgc cgcctcgcct tctgcgctac tgggtgaaca gcttcgccgc
     1081 cgtgatcacc gtctgcacca ccccgtagcc cagcagcacc gacaccacca gccacgacac
     1141 caccaggcgg gtccgctgcc cgccaccgct gtgctcgttc acgatccgct cctctccgtc
     1201 ggcccctgcg ctgtcccgtc ccgtcccgac gccggctcgt ggtagcgctc cggcaccggc
     1261 cgcaccagca ggttcgccac caggccgacg gccagcacgc cgaccatcgt gaacagcgcc
     1321 ggccggtacg ccgccgcggt caacgtgccc ggctcgccct gcgcgtcgag gaacccgttg
     1381 acgatcagcg gcccggccac cccggccgcc gaccacgcgg tcagcagccg gccgtggatc
     1441 gcgcccacct cgaacgtgcc gaacaggtcc cgcaggtacg ccggaatggt cgcgaacccg
     1501 ccgccgtaga acgacaggat cacggacgcc agcagcacga acaacgccgt cgaggtctgc
     1561 cccaccagcg ccagcagcag gtacagcacc atgcccacac ccaggtacac cacgtagatc
     1621 ggcttacggc cgatcacatc cgacgtggac gaccacacga accggcccgc catgttgaac
     1681 agcgacagca ctcccacgaa cccgccggcc gccgccaccg acaccgccga ggtcccgttg
     1741 tcgcggaaga agtcctggat catcgggctg gcctgctcca ggatgccgat acccgccgtc
     1801 acgttgcaga acagcaccac ccacagcagc cagaacgacc gcgtcttcag cgcgttggcc
     1861 gccgacacgt tcgccgtggt caccagcggc ttcttcgcca ccgtcgacgg gtcgaaaccg
     1921 gccggccgcc agtgcggcgc cggcacccgc acgttgaaca ccccgaacat catgatcacg
     1981 aagtagccga tgccgagcgt cacgaacagc cacaccagcg ccgagcccga cgcggtggaa
     2041 ccgctgtccg acgggtcgta cccggcgtcg tagaacgaca gcagctgccg ggacagggga
     2101 gaggccacca tcgccccgcc accgaacccc atgatcgcca gcccggtcgc cagccccggc
     2161 cggtccggga accacttgat caacgtggag acgggggaga tgtacccgat ccccagaccg
     2221 atcccgccca gcaccccgta ccccaggtac agcagccaca gctgcccggt cgcgatgccc
     2281 agcgccccga ccaggaatcc cgccgcccag aaacacgccg acacgaacat ggccttacgc
     2341 ggcccgttcg cctccaccca cgtaccggcg accgcggccg acaaccccag catcacgatc
     2401 gcgatgctga agatcacccc gatcgccgtc tgacttgtgt cgaaatgcgc gatcagggag
     2461 ttcttgtaca cgctcgtcgc gtacacctgc ccgatgcaca gatggatcgc cagcgccgcc
     2521 ggaggaatca gccagcggct gtaccccggc ggcgcgacgg tgtgccgacg atcgagtgcg
     2581 gaaagcatcg ttgcttcctc cgtccagaag gcgagaacag cccgttcatg cccccaccgc
     2641 acgctgcgcc caaacccgcc ccgcgcccgg cggtcgaaac cctgagccga acggtcaccg
     2701 cggtcccggc ccgtcatcac cccaccacgg gccgtcagcc ctcgccgggg atgcgaccat
     2761 gagcaggtga agatcctgtc catccagtcg tcggtcgcct acggccacgt cggcaactcc
     2821 gccgccgtgt tcccgctgca acgcctccga cacgaggtct ggccggtcct gaccgtgcac
     2881 ttctccaacc acaccggcta cggcgcctgg cgcggccccc tgctcgcccc caccgacgtc
     2941 gccgacgtca tcgccggcat cgccgaccgc ggggtgctcg gcaccgccga cgccgtgctc
     3001 tccggctacc agggcgaccc cgccgtcggc gcggtcatcc tcgacgccgt cgcccaggtc
     3061 aaagcggcga acccggccgc cctctactgc tgcgacccgg tcatgggcga cgtcggccgc
     3121 ggcatgttcg tccgccccgg catccccgag tacctccgcg acaccgtcgt cccccgcgcc
     3181 gacatcgtca cccccaacca gttcgagctg gagttcctcg ccggccgcac caccgatacc
     3241 ctcgacgacc tgctcgccgc cgtcgacacc gtccgcgcca ccggcccccg gcacgtcctg
     3301 gtcaccagcg tcctgcacgg cgacctgccc gccgggcacc tggaagtcgt cgccgtgtcc
     3361 gacgagggcg cctgggccgt caccaccccg ctgctgccga tcgcccccaa cggcggcggc
     3421 gacgtcaccg ccgccctcta cctggcgcac ctcgccacca ccggctcacc acagaccgcg
     3481 ctggaacgca ccacaaactc gatctacgcg gtactcgagg cgaccctcga cgccggcacc
     3541 cgggagctgc aactcgtcgc cgcccaggac gccatcgccg agccgcccac ccggttcacc
     3601 gcccgccggc tgcgctgacc gccgcccggg tgcaccagcc gcccaggtgc acccgggcgg
     3661 cgactcgccg ctcgaacagg tggacgacac caccgcccag caggcaggat gcggacgtgt
     3721 caccgcacca gggcaccgac gaccccgcgt tcgcccaacg gctgcgcgac ctgacccggc
     3781 tgcgccgcgt ccgcgaccgc atcgaccgcg agtacgccag ccccctcgac gtcgaagccc
     3841 tcgcccgcgg cgagcacatg tccgccggcc acctcagccg ccagttccgc cagacctacg
     3901 gcgagtcccc gtactcgtac ctcatgaccc gccgcatcga acgcgcgatg gccctgctgc
     3961 gccgtggtga cctcagcgtc accgatgtct gcttcgccgt cggctgtcag tccctgggca
     4021 ccttcagcac ccggttcacc gaactcgtcg gcgaaccgcc cagcgcctac cgcgcccgtc
     4081 acgcccccga caccgccgag ccgcccccgt gcctgaccaa acaggtgacc cgaccgatca
     4141 ggaatcgaga agcccgcacc ggccggccac cgttagcgtg accaccatga cgatcaccat
     4201 tcactacacg ttcctgccgc acaccgacgc cgacgccgcc atcgccttct accgcgacac
     4261 cctcggcttc gaactgcgca acgacgtcgg ccagggcgac accatgcgct ggctcaccgt
     4321 cggcccaccg aaccagcccg agaccggcat cgtcctgcac ccgccggccg tcgaccccgg
     4381 catcagcgac gacgagcgcc gcaccatcct cgaactcatc gccaagggca gctacggcgc
     4441 gctcaccctc gccaccgacg acctcgacgg cctgttcgac cggctggcgg ccagcggcgc
     4501 cgacgtggtc caggaaccca ccgaacagcc ctacggcgta cgcgactgcg cgttccgcga
     4561 ccccaccggc aacctcatcc gcatcaacga gcggcgctga cggcgcccgc ggcggacgct
     4621 ggctcgaccg gaacacccga cccggacgga gagaccatga gcgaggccac caccggcctg
     4681 caccgcgccg acagccacga cgtcatccgc gtcctcggcg cccgcgagaa caacctgcgc
     4741 gacgtccacg tcgaactgcc caaacgccgc ctcaccgtgt tcaccggcgt gtccggctcc
     4801 ggcaagagct cactggtctt cggcaccatc gccgccgagt cccagcgcct gatcaacgag
     4861 acctacagcg ccttcgtcca gggtttcatg cccaccctgt cccggcccga ggtcgacgtc
     4921 ctggagggcc tcaccaccgc catcatcgtc gaccaggaac gcatgggcgc ggacccacgc
     4981 tccaccgtcg gtaccgccac cgacgtcaac gcgatgctgc gcatcctgtt cagccgcctc
     5041 ggcgaccccc acatcggccc gcccaacgcc tactcgttca acgtcccctc cgtacgcgcc
     5101 gccggcgcga tcaccgtcga ccgcggcccc ggcaagaccc agaccaggaa gggcaccttc
     5161 aaccgcctcg gcggcatgtg cccccgctgc gagggccgcg gcgcggtcac cgacttcgac
     5221 ctgaccgtcc tctacgacga gaagttgtcc ctcaacgagg gcgccatcac catccccggc
     5281 tacagcatgg acggctggta cggccgcatc ttccgctcca gcggcctgtt cgacccggac
     5341 aagccgatcc gcgactacac caagcgggaa ctgagcgacc tgctccacaa ggaacccacc
     5401 aagatcaagg tcgacggcat caacgtcacc tacaccggcc tcatccccgc catcagcaag
     5461 tcgatgctcg ccaaggacgt cgacgccatg cagccgcaca tccgcgcctt cgtcgaacgc
     5521 gccatcacgt tcaccacctg ccccgactgc gacggcaccc gcctggcccc cgaagcccgc
     5581 tcctcgaaga tcaacggcgt cagcatcgcc gacgtctgcg ccatgcagat cagcgacctc
     5641 gccacctggg tacgcgacct gcgcgaaccc tccgtcgccc cgctgctcaa ggcgctgggg
     5701 gacaccctcg actcgttcgt cgagatcggc ctgggctacc tcagcctcga ccggcccgcc
     5761 ggcaccctct ccggcggcga ggcccagcgc accaagatga tccgccacct cggctcgtcc
     5821 ctcaccgacg tcacctacgt cttcgacgaa cccaccatcg ggctgcaccc gcacgacatc
     5881 gcccgcatga acaacctcct gctgcaactg cgcgacaagg gcaacaccgt cctcgtcgtc
     5941 gaacacaaac ccgaaaccat cgccatcgcc gaccacgtcg tcgacctcgg ccccggcgcc
     6001 ggcaccgccg gcggcaccat ctgctacgag ggcaccgtcg ccggcctgcg cgccagcagc
     6061 accaccaccg gccgccacct cgacgaccgc gcaaccctca aggacaagcc gcgtacgccc
     6121 accggcgcgc tgccgatccg cggcgcccgc acccacaacc tgcgcgacgt cgacgtggac
     6181 atccccctcg gtgtcctggt cgtggtcacc ggcgtcgccg gttccggcaa gagcagcctc
     6241 atccacggct cactggccag acgcgacgac gtcgtcagcg tcgaccagac cgccatccgc
     6301 ggctcccgcc gcagcaaccc ggccacctac accggtctgc tcgaccccat ccgcaaggcg
     6361 ttcgccaagg ccaacggcgt caaacccgcc ctgttcagcg ccaactccga aggcgcctgc
     6421 ccgacctgca acggcgccgg cgtcatctac accgacctcg gcatgatggc cggcgtcgcc
     6481 agcacctgcg aggactgcga aggcaaacgg ttccagcccg ccgtgctcga ctaccacctc
     6541 ggcggccgcg acatcagcca ggtcctcgcc atgtccgtcg acgaggccga gatcttcttc
     6601 agcgacggtg aggcccgcac cccggccgcc cacaccatcc tcgaccggct cgccgacgtc
     6661 ggcctcggct acctcacgct cggccagccg ctgaccacgc tgtccggcgg ggaacggcag
     6721 cgcctcaagc tcgccacccg gatgggggac aagggcggcg tgtacgtcct ggacgaaccc
     6781 accaccggcc tgcacctggc cgacgtcgcc cagctgctcg gcctgctcga ccggctcgtc
     6841 gacgcgggca agtccgtcat cgtgatcgaa caccaccagg cggtcatggc gcacgccgac
     6901 tggatcatcg acctcggccc cggcgccggt cacgacggcg gccggatcgt cttcgagggc
     6961 accccggcgg atctggtggc cgcccggtcc acgctcaccg gcgaacacct cgccgactac
     7021 gtcggcgcct gaccggcgcg cccgctgaga cccccggccg cgccgcgggt ctcagcggga
     7081 caggccggcc atccgggccg gcggcgccgt gccgggctcc accaggccgc actggtacgc
     7141 ggccaccacc gcgtgcgtcc gatcccgcag ccccagcttc gtcagcaccc ggctgacgtg
     7201 cgtcttgaca gtcgcgtcgc ccagcaccag atgctcggcg atctcccggt tcgacatccc
     7261 gtacgccatc agcaccagca cctcccgttc ccgcggggtg agccggcgca tctgcaccgg
     7321 ggtgggcagt cccgggtcgg gccgggcggc gaggtcgtcg agcagccgcc gggccaccgc
     7381 cggatccagc cacgcctcgc cgtcggccac cgcccggatc gccgacacca gctcggcggg
     7441 cgcggcgtcc ttgagcacga aaccggacgc gcccgcccgc aacgcggcgt gcaccgcctc
     7501 gtccacgtgg tacgtggtca gcatgatgat ccgtaccggc tgctgcgggt cgtcgatgag
     7561 ctgctcgtcg gccatcagcc tggtcgcggc caacccgtcg gtgccgggca tccgcacatc
     7621 catcagcacc acgtccgggc gcagccgccg actgacctcc acggcctgcg ccccgtcgtc
     7681 ggcctcggcg acgacctcga tgtcaggttc gttggtgagc agcatcgcga gtcccgcccg
     7741 tacgagcggc tggtcgtcgg cgagcagcac ccggatcatg aaggctcccg tcgtcggcgg
     7801 ccgggacagt ggccccacca catgatcatc gacgccggcg gcggcggcca ccctgatgtc
     7861 gcacagcgga cacgccgttc acccgacagc cggcgccccg ccgtcacccg aggccgccac
     7921 caggtcgccg tgctgcgcga ccggcagcgt cgcgctcacc cggaacccgc cctcggcacg
     7981 cggcccggcg accagacgac cgccgacacg ctccagccgc tcggcgaggc tggccagccc
     8041 gttaccggtc gacagtcccg ccgccgcgcc cgcctcgcgg cccgagccgt cgtcgtcgac
     8101 gcgcagcaac agcacccgct cctgccaccc gaaatgaaca gtcgcgcagg cccgccggcc
     8161 gacgtgcttg agcgtgttcg tcaggctctc ctgcaccgtc cggtacgccg ccagctcgat
     8221 actcggatcc agcggcctgg gactcccgga caccgacatc gtcaccgtca gccccgcgca
     8281 ccgcatcgac gtcagcagca cctcgatgtc gtccagccgc ggctgcggac ccggctcacc
     8341 gtcgcccacc ggccccgact cggcccgcat gaccgccagc agccgccgca actccgccat
     8401 cgcctgctgc ccggcctgct ggatgtgcag cagcgcctcc cgggtccgct ccggatcgga
     8461 cgcgctgatc cgcgccgcgc cagcggcctg caacaccatc accgtcaccg agtgggacac
     8521 cacgtcgtgc agttccgcgg cgatccggcg acgctccaac gccaccgcct ccgcccgcgc
     8581 cacacgccgc tcccgctcca actgggccac ccgccgccgg tgccgccgca ccaccgaccc
     8641 ggccgcccac gcagccgcgt agatgagcgc gaacatcaac gcggtcacca cgaactcccc
     8701 ggcccgcgcg cccgcactcg gctccacccg gaacgagtcg aacgcgctga gcaggctccg
     8761 cgcgcacgcc gccgcgtacg ccgccgccga caccaccagc ggccgcaacg ccgccaccgt
     8821 gtacaacgcc acgatcaggc ccacccacgg ccggtagtcg tgcagcagga accacatcgc
     8881 cacgccgtgc acgcactcga acgcgaacac cgccaccggc gcgcgggccc gccaccacag
     8941 ggcgccgacc gacaacaccg cggcgagcac ctgcaaccac tgccgggccg ggccgaccgg
     9001 ctcgctctgg atcaccacgg acgacgccgt gaacaggtcg agcaggccca gcaccggcag
     9061 cagcagaaga tcgtgacgcc accatctcgc cgcccgcgcc ggggcggacg gcgccaccgc
     9121 accggtcacc gacgtcatcg gcggatcagg agttttccgt agggcagccg atgccgaaca
     9181 accggcacgt ccaggacagc ggcgagccgt cgtcgtcacc gccgccgtca ccgtccggcg
     9241 acggcgtggc cgcgcccacc cggtgcgtgg tcaccggcac cgccgtccgg cccggcgcac
     9301 ccgcccggcc cgcccccacc agcacgaccg gcgccacgac gtcggccgcc gcgtccgcgg
     9361 ccacccgcca ccgcccgtcc gcgtcgtcgg cgagcatcgc caacacccgc cgcaccgcca
     9421 aggcatcagt gccgtgccca ccgggaaccg tcgcgccggc cagcgacacc atcaccaggt
     9481 ccgcctcgtc acggtgcaac accgacacct cggcgacagc gagcgaccgc gcgtccccgc
     9541 cggccacccc caccagccgc accgcgtcgc cggaacgcgc ccggcccgca cccaccgtcc
     9601 tcagcagaca ccgccgtccg tccaacggca ccccacgcgc gacggtcacc caccccgccg
     9661 gccgctgcgc ctgcaggaac accaccaccg gcggcgactg gacctcggtc ctcatcacag
     9721 acctccacag aaggaaatgc gggcgaacag cccgcgtacg cgagaaattc tggtccacac
     9781 cggcccgccg gacgtccccg taccgggtga catccggtgt ccacttccag acggaccccc
     9841 gacgcccacc accgggccgg gacggacccc gaacctcgcc ccacggccgg acgccagcac
     9901 cggccggcta ccaccacgat ggaaccagtc caggcgacaa cggcaacaca ccgaaccgcc
     9961 ccggacaccc aacccattcg tcacggccgc gaggtttgcc atgcccacgc ccggagcgtt
    10021 cctgatcgcc gacccggtcc acgtcgactc accggcgtac gtcgccgaca cggcgagccg
    10081 gttcccgctg gccgaccaga ccccgcccga cggctggcgc gtcgccgaac acggcggctg
    10141 gatcatgtgg cacccgccgc aggcgcagct gccccagcag ggctggaaag tccacgtgtc
    10201 ggtgaacctc gacgacgccg ccgacgtcct cgacctggta cgcgaccact gcgtgaccca
    10261 ccgggtcgcc ttcaagttcc aacgcagccg ccgcctcgcc ctggtcaaca acgagaagta
    10321 cgcccaccgc gccggcagcg gcaaactcgc cgccctctac ccggccgacg acaccgccct
    10381 gcgccgcgtc ctcgacgacc tcggcgcccg cctcgccgga taccgcggcc cctacgtcct
    10441 cagcgacctg cgctggcacg acggacccct ctacctgcgc tacggcggat tcgccgagct
    10501 ctggtgcgtc gacggcgacc agcccgtccc cgccgtcgca cgccccgacg gaaccctcgt
    10561 ccccgaccgc cgcgaacccg tcttcaccgt gcccgactgg gcccccgtgc ccgacttcgt
    10621 cgccgagcac atcgccgccg tcgccgctgt cgacgcgcag acggacgacg aacccccgta
    10681 ccgcatcgag gaagccctgc accactccaa cgccggcggc gtctaccgcg ccaccgacct
    10741 gcgcgacggc cgcaccgtcg tcctgcgcga agcccgcccg cacgccggac tcgacggcgc
    10801 cggaaccgac gcgctcaccc gcctgcgccg cgaagagacc atgctgcggc gcctcgccgg
    10861 cctcgactgc gtaccccaac tactcgaccg cctcacctgg tgggaacacc agttcctggt
    10921 cgaagagcac gtcgacggcg acaccctcca acaccacctc gccatgcggc acccactcat
    10981 ccaccccgac cccaccgagc aggacctcac cgactacacc acctgggcac tcgacgtcat
    11041 cgaccaggtc caggcagccc tggcccagat acacgccagg ggagtggtct tcggcgacct
    11101 gcacaccgcc aacatcatga tccgccccga cggccggatc gtgctcgtcg acttcgaaca
    11161 ggcgtacctg accgacgagg acttcacccc ctcactgggc gaccccggat tcgccacacc
    11221 ccgcatccgc cgaggcaccg ccgtcgacac ctacgccctc gcctgcctgc gcctcgccgt
    11281 cttcgtacca ctgacaccac tcgctgccct gagcgacgac aagttcgacg acctcctcac
    11341 gatcgcccgg cgcttcccag taccacccgg atacctcgac cgcatccgcg acgacctgcg
    11401 caccgcactg cacccaccca cgcccggccg ccgccgcgtc acccgccacc agtggtccgc
    11461 cgacccgcgc cagctgatcg aatccctggc cgccggcatc cgcgccaccg ccacaccgca
    11521 ccgcaccgac cggctcttcc ccggcgaccc cggccagttc ccccacggcg gcgccaccct
    11581 cgcgcacggc gccgccggca tcatctgggc actcgtcaac accggcgtcg actaccccga
    11641 acgcgacgaa cacctcgact ggctcacccg cgccgcccac cgcctacccg ccgcccacct
    11701 cggcctctac gacggcctcg ccggcatcgc cgccctcctc gaccgcaccg gacgccacga
    11761 cgacgccgac gaactgctcg accgatgtcg caccggcctg caccaccgct acggccccgg
    11821 cctgcacagc ggcctcgccg gcatcggact cgccctgctg cgccccggcc gacccgcccc
    11881 cgacgacgcc ctgcacatcg gcgaccgact cgcccgcacc ctcaccggcg acaccacgca
    11941 acccgtaccc gaacccaccc gccccggcct gctccacggc tggtccggcc ccgctacctt
    12001 cctcacccgc ctgcacgaaa ccaccggcga ccccgcctgg ctccgcgccg cccgcaccgc
    12061 cctgcgccgc gacctgcaac acaccgtccg cgacgacaac ggcaacctcc acgtacgcga
    12121 cggcgcacga cgactgttct acctcgacga aggcagcgcc ggcatcgccg tcgccgccca
    12181 cacactgctc cgccacggcg aacgccagtg gctgcgcgac atcgtcacca ccgtccgccg
    12241 caccatcgac gtcgaattcg tcctgctgcc cggcctcttc cacggccgcg ccggactcct
    12301 cgccaccgcc gccctgctca ccgacgaccc accgcgccgc gccaccccgc accgccccgt
    12361 cggactcgtc cgcgacgacg cgccccacca cgtccccgcg cacctgaccc gcctcgcctg
    12421 gcacgcctac gccctcgacg gccacctcgc gttccccggc gacaccctgc tgcgcatctc
    12481 caccgacctc gccgccggcg gcgccggaat cctgtccgcc atgcacgccg cgctgcaccg
    12541 caccgccgtg acgctgccct tcctcgacgc gcccacccac gtcgcgccca ccggccacct
    12601 cctcgccgcg agctgaaccc ccgcccggcg cccacagacc ccgtcggaac caccgacggc
    12661 caacccacca cacccgagaa ggaggtgaac ccccatgacg aagctcctca acctgcaggc
    12721 catggccacg cagaacggca cccgccacgc ggtcccgccg cagtccagca gcatcagcat
    12781 cgcctgctgc aacggctgag acggcagtgg cgaacgggcc accagcccca gccacacctg
    12841 atccgcctgg cgacccgggc gggcggccac cgcccgcccg ggtccgtcgt caacccggcc
    12901 cggtgaagcc ggcatcccgc ccgccaccac gcacacggag cccccatgcc gcccaccggc
    12961 ctacgacaca accgcgactt cctcctcatc accgtcgccc gcaccgcgtc gaaactcggc
    13021 acccaggtca ccgccgtcgc cacgccgctg ctcgtcctgc tgaccaccgg ctccgccacc
    13081 gacgccggcc tcgtcgcctt cgccgaaggc atcgccctgg tcctcgtact cctgcccgcc
    13141 ggcctgctcg ccgaccgccg cgaccggcgc atcctcatgc tctgctgcga cgccggcgcg
    13201 ctgctcgccg tcaccggcgt caccgtgctc gccctcgtcg gacacgcgcc agtcctgctc
    13261 atcgccgtcc tcgccgccgc caccgccggc ctcggcgccg cgctgcaacc cgccgccgca
    13321 gccgccaccc gcgccgtcgt cccagcccgg gacctgcgta cggccaccgt gttcaacgag
    13381 acccgcaacg gcgtcgtcca cctcgccggc ccgccgctcg gcggcttcct gttcggcctc
    13441 gccccggcac tgccgttcct cgtcgacgcg ctctcctacg ccgtctccct ggtcgccgtg
    13501 gccctgctgc gcggcccact cggccggtcg gcgaccacgc cgggggagtc cctgccccgg
    13561 caggccgtcg ccggggtccg gttcctgtgg cggcaaccgt cgctgcggtt cacgctgctc
    13621 tgcggcgccg tcctgaactt cgcgttcgcg ggcgtcctgc tggcgatcat cgtcgtgccg
    13681 gtccgcaacg gcgcctccgg actgtccgcc ggaaccgtga tggcatgcgt cgggctcggc
    13741 gccgtcgccg gatcactcgt cgcgtcctgg ctgaccgccc gggtacccac ccgctggctg
    13801 atcctcgccg tcgtctgggc ctgcgccgtg ctgaccgccg cgatggccac caccgacaac
    13861 ggactggtcc tgggcgcgct ggccggcgcc tgcgtcctgg tcgtaccggc cgccaacatc
    13921 agcatgctga ccctccagac cctgctcacc cccggcgacc tgcaggggag agcgaacgcc
    13981 gcgaccagct tcatcgcgct gatcgtggcg ccgttcggcc cggccctgtc cggcctgctg
    14041 atcgaccgcg taccggcgcc ggtggtgttc ggcagcttcg cggcgatcat gctggcgctc
    14101 gccgtcggcg cggccgtcgc gcccgccgta cgcgccatgc ccgacctgcg ggccgtcgag
    14161 gaagccccgg agcccggcga ggccgagcgc cgcgacccgc agccggtctg agctgatctt
    14221 cgtaccggca ggcaggggag aggtgctggt ctttccgggg acgttcggat gatcacgaga
    14281 gcgcctcgcc cgtgccacca tgtagggccc tcccaggaca ggccacaagg gacgaggtgc
    14341 cggcatggag ctgcgtagga gccgagagaa gctgtggagg ggcctcacgg tcttcggagt
    14401 cggcgtgctc ccgctgctgt accacacttc cgcgtcgacc ggacgatgga tccttctcgg
    14461 cctctggctg gtgtcggccg gcctgttcgt cgcctaccag ctcaggccgt tccggttccg
    14521 catcggagcc gacggactgg atctgcgggt cgccgggctc aaccggctgg tggcatgggc
    14581 cgagatcgac gctgtcgtgc tcgaccagcc gctaccgtcc cgtggccgga accagagagc
    14641 cgcaaaggtg ctgctggtgc cggccaccgc cgcgacgatc gaccgtccgc tcaccggccg
    14701 gagcccggtc gacgggcggc cggccctgaa gctgctcgac ctcgatcagg tgcggcagcc
    14761 ggcggacgac gtggcggacg ccctggcccg gttcggggca gggcgattcg cggacgtccg
    14821 gcagcaggcc ccggaactgt ccgacgacgc ggatacgccg gacacggagg ccctgacgtt
    14881 gttggccgac ctgacaccgc gagtccagaa ggcgctcgac tcggggcagg tgtcgcagcg
    14941 gcaggcggtc aaggcagagg tggacgcggc actcgcgaga ctgcaggccg gaggtcacca
    15001 gccacggctg gccgcgcttc tgaaggtcat gtcggacacc ctcggcgaag acgtaaagcc
    15061 ctcctgagcc gtgattcgat aatgcacatt atgtcaagta aagctccggc gggcctcccc
    15121 ggacgtcctc gcgaggcggc tgaccttccg ggacttggag gtccggccag ctgccccgtc
    15181 gcaccgcaca cctaggcgcg gcccgccgac gccgcactct caacccatcc accgctccgg
    15241 cgatcatgag gttggcggcg acaaatggga cagcatccgc ggtcaacttc atgatcgccg
    15301 gagcgcagag ggcgccgacc cctttcaccg ccctccctgc tccggccgag tgccgacagg
    15361 tgtgactgcc gctgccagta cgcggatgtg gccgcatcgg agcgcccggg ttgccgccac
    15421 ctcggcgtag tggagttgat catcgagcga gcgggccgca ctccccctcg aaaggacccc
    15481 ctggcaggaa cgcgagaatc atgcataata tcccttatgc atgacaaacc ggacgaaacg
    15541 gtaggtgctc tgattgagga gttcctgacc gcccgggcca cccgcaagcc ctccccccac
    15601 accctggccg cgtaccggag ggatctgacc gcagtggccg agctgatcgc cgccgacggc
    15661 gacgccactc ccctccccct ggaccgggtc gcggtcagct ccctctcccc cagagtgatg
    15721 cgcgcggcgt tcgcgcggtt cgccgctccc cgcgccgccg cgtcggtcca tcgtgcctgg
    15781 tcgacgtgga acagcttctt cacgttcctg gtggccgagg gcgtcgtacc gggcaatccg
    15841 atgccggcgg tggggcggcc ccgtacgccg ctcccccgac ccaagccact gcggggcgag
    15901 gacaccccgg aggaactgct ggcggcggtg gcccgggcgg agggccggca gcgtgacccg
    15961 tggccggagc gcgacctggc ggtgctggcg ctggcgttgt gcgccgggtt gcgcctgtcg
    16021 gaactgctgg cgctgcgggt gtcgtcggtg gcggggcgcg acggcgagcg gcgggtggac
    16081 gtggcgggca agggcgggcg gccgcgtacg gtgccgatcg aggatgccgt ggaccgggtg
    16141 ctcacgggtt atctggacag ccggcggctc cggttcgggg cgcgcagtgt gcggccggac
    16201 gctgcgttcc tggtggaccg ccagggtgag gcgttgcggc ggggtgggct gcagtacctg
    16261 gtggagtcgt gttaccggcg ggcgggcatc ggtgaccggg tgccccgggg cgcgcgcttg
    16321 cacgcgctgc ggcacacgtt cgcgacgcgg ttggcggagg acggggcgag cgcggcggag
    16381 atcatgcggt tgctggggca tgcgtcgttg gcgtcgtcgc agacgtacat cgaggtgacg
    16441 gcgggtcagc agcgggcggc ggttgcggcg aaccgtacca atcgggcgtt gtcggggttg
    16501 ctcaagcggt agtggtcagg ccgagttgag cggccacgta cgccaggtgg tgtgacgttc
    16561 cccaagcgat ccaatccgtg gcgacgccgg tcccggcatg gcctgcggct cgcagagcga
    16621 tctgctcgtc gccccaggag aagtgccgtc cggcggccgg ccaatggtcg gcggacacaa
    16681 gggccttgca gatgtcgtag atgccgatgt tgcccttgcc gtcgcgcgtc gtccggtacg
    16741 tccaccaggt atcgcggccg gtgtgccgga tgttcggcgc tggtccccag cctttgccgc
    16801 tcgtccccgg atgagcgatg cagtagtcgg cgaattggac gccgtgctgc tgaagtcgct
    16861 gccacagttc gaagtcccgg cgacggagtg gggttgcccg atgaggcgga acctgcgaga
    16921 gattcggggg catgccgccc gacgcgacga cgacgtcctt ccagtgatgg cgtcgggtcc
    16981 acgcgaggtg cttgcggagc aggggttctg ccttcgtgag gtcctggtcg gagcgcacct
    17041 cggcggcgtc gaggacgacg atgcagtcct cggtacgcaa ctcgatcacg gccaacacct
    17101 gagaaagccg accgtcgact tcggtgacgt ctggttcggc gtggctggcc gtgactcgca
    17161 cgacgccgcc tccgtgcatg gcggcggcgc tacgcacgtc cgcaagttgt tgggttgtgt
    17221 cctgcaggtg cacgacgggc agcgctgaga ttctccaggc ttccaggtcg acggcgatgt
    17281 cgtggagtgg tcggcgagta ccggtcatcg gttctggaag gtgctgcaca tcgacagcga
    17341 cgaccatgcc gggaggaagt gttcgcttta cacgttcgat gaacttgcgg gcgtcttcga
    17401 tcggtccctt gtcaggcacg acttcgaaga tcgggacgat gtgtggcgcg agttcgccag
    17461 cgaggttgtc gatggcctgg aactcagctt ttcgaccttt gaggatcgga tagtagcccg
    17521 ccatggcatc gccccacacg attcgacgac agtcacttgt atcgatgttg cacgttctgt
    17581 gcccgatcta caaccgtgcg tatccagaat gggtgagtca atgcgctgcc gggctggcag
    17641 gatcgggcgg atgcgggtgg gtgcggcgcg ggcggtggcg gccgggtggg tacgggagcg
    17701 gatgcgcgtt gacccgtcgg tcgagggggc gttcttcagc gggtcgactg tggggttgcc
    17761 ggacgacgcg cagttgccgc cgtggtcgga cgtggatgtg ttgctggtgc gccgggagcc
    17821 cggtgcgaag gtgggcaagt tcgtgcatcg gggggtgctg ctggaggtca gcacgatcac
    17881 gtgggcggag ttgggcggcc cggaggatgt gctggggtcg tgggtgttcg cgccgatgtt
    17941 gcgtaccgat ggggtgatcg cggatccgtc gggccggttg ggcgcggtgc gggagcgggt
    18001 ggcggcggcg ttcgcggatc cggtctgggt gcgggcgcgg tgtgcgggtg tgcggcggcg
    18061 gatcgaggcc gggttgcggg cggtcgacgc cgagctgcca accgcggagc aggtgttgac
    18121 gtgggtgttt ccgacgtcgt tgctggcggt gtggccggcg gtggcggggc tggtggatcc
    18181 gacggtgcgg cggcggtacg tgcgggcgga gcgcgtgttg tcgcggttcg ggttcgcgga
    18241 ccggtatccg gggttgctgg acacgctcga cggcggcggg gtggggttgg gtccggcgcg
    18301 ggtgcgggcg catctggccg ggttggcggt ggtgttcgac gaggtggcgc ggttgccgcg
    18361 ggaggggttc gcgttcgggg cggatctggg tgcggcgggg cgtccggtgg tgttcgacgg
    18421 tgcggttgag ctgatcgggg cggggcggca tcgggaggcg atgttctggg tgctggtgac
    18481 gtacgcgcgg tgtcatgtgg tcttgggcgc ggtggcgccg gagcgggagc gggcgttgcg
    18541 gccggcgttc caggcggtgc tggcggatct gggtgtggcg tcggcggcgg atcggcggcg
    18601 tcgggcggac ggtctgctgg cggcgttgcc ggggtggcag gtggtggtgg atgcggtggt
    18661 ggcggaggct gtggcaggct gagggggaac gcgactggcg gcacggggat gggtgaacca
    18721 tcggggagct cgtcgtgggg gtcgaccgcc tgggcccctg cgggcgaggt gtcgtatgtc
    18781 ttctgcgcgg ttgttgccgg gtgctccggt ggcggagcgg gtgttgtcgg aggtcgccgc
    18841 gtcggtggcc gagttgcggg cggcgggggt gacgccggcg ctggcgacgg tgctggtggg
    18901 tgacgacgac gcgagcgcgg gttatatccg gatcaagcaa cgccaggcgg cggagttggg
    18961 tttcgtgtcg ccgcacgtgc atctgccggc gtcggcgtcg caggcggatc tgcatgcggt
    19021 gctggcggat ttcaacgcgg acgccacggt ccacggggtg ctggtgcagt atccgatccc
    19081 gggtcatctg gactacgacc gggcgttggc ggtgctggat ccggacaagg acgtggacgg
    19141 gatgcatccg gtgaacatgg gccggctggc gttggggttg ccgggtccgt tgccgtgtac
    19201 gccggcgggg atcgaggcgt tgctggcgtt tcacggtgtg ccggtggcgg gccgggaggt
    19261 ggtgatcctg ggccggggtg cgacgttggg tcggccgctt gcgatgttgc tggcgcagaa
    19321 gcggccgacg gcgaacgcgg cggtgactgt ggtgcacacg ggggtggcgg actggccgcg
    19381 gtacacgcgg cgggcggaga tcctgatcgc ggcggcgggg gtgccgggga tcgtgcggcc
    19441 ggagcatgtg cgtccgggtg cggtggtggt cggtggtggg gtgcggtacg aggggcggcg
    19501 gttgctgccg gacgtggacg agtcgtgtgc cgaggtggcg ggtgcgatca cgccgcgtgt
    19561 gggcggggtg ggtccgacga ctgtggcgat gttgttccgt aacgcggtgg acgcggcgcg
    19621 gcggcaggcc gggctgggtt gagcgtcagc cgaggtcgac gacgaggggc cggtggtcgg
    19681 agatggtggc cagcggtgtg tggacggcgg tgacgggtgg gagccggtcg agtgcgtgcc
    19741 ggtcggcgag gatgtggtcg agttggacgc ggggttgccc ggccgggtag gtggggcggc
    19801 gggcgagggg tcgccagcgg gtgagcgcgg cggcgggtcc ggcgggcagg ttgaggtcgc
    19861 cgagcaggat ccggggtgcg ggcagggcgc gcagggcgcg gatgacgcgg cgtagttgcc
    19921 agacgttcca gccggggacg aaggacaggt gggtggcggc gacggtgagg gggccgtggg
    19981 gggtgtcgag gacggcggcg agcacgacgc ggggttcgtc gcggagcagg atgaggccgc
    20041 cgccgggtcc gggtgcgtag atgggtgagc ggacgggggc ggcgcgtagg cgggtgacct
    20101 gccaggagcg gacggggtgg cggctgatca ggccgatgcc gtagaggggt tcgccgtggc
    20161 cgtcgtcgtc gtgggtgagg gggcggaact gttctccggg ggtgccgacg acggcggcgg
    20221 cgaagcggtg gtggtcggcg tgcagggcgc gggcggccag ggcggtgagg tcgagtttgc
    20281 cgctgcgggt ctggtcgcgg tcgacttcct ggagggcgag gacgtcggcg tcgagggcgg
    20341 tgacggcggc ggtgagccgg tcggggtcga cgagtccgtc ggtgagggat cggccgtgca
    20401 gcaggttgaa ggtggccagg cgcacctgga caccctacgt cgtcgtggca gtcttgccgg
    20461 gtgctgagac tgttgtgctg ttcgatgctg gtgttcgtgg cggtggggtc ggtgggggtg
    20521 tggttgcggc gtcgtcgggg ccggtgaggc ttgccacagg tggcgttgtc gctggtggcg
    20581 gggtgggcag aatgcggcgg tggatgccct gtcgttgacg acgttgctga ccgctgccct
    20641 tgtcgcgggg tgggtggacg cggtggtggg tggcggtggt ctgttgttgt tgccggcgtt
    20701 gctggtggcg gcgccgggtg tgccggtggc gacggcgttg ggcacgaaca agctggcggc
    20761 gattttcggt acgtcgacgg cggcggtgac gtatgcgcgg cggacgaagc tggactgggg
    20821 tgtggcgggt ccggcggcgg ggttggcggt gctgacggcg gggttgggtg cggcgcttgc
    20881 gggtgcggtg ccgggtggcg cgtaccggcc ggtggtgctt gtggtgctgg tggcggtggc
    20941 ggtgttcgtg atggcgcggc cgtcgcttgg tgtggtgtcg tcgccgcggc gcacgccggg
    21001 gcgggtggtg gtggcggtgg cggtggccgg gttgggcatc gccctgtacg acgggttgat
    21061 cggtccgggt acgggcacgt ttctggtgtt ggcgttcacg gcgattctgg gttcggattt
    21121 cgtgcacgcg tcggcgatgg cgaaggtggt gaacgcgggt acgaatctgg gtgcgcttgt
    21181 ggtgttcggg ttgacggggc acgtgtggtg ggcgttgggt gcggcgatgg cggtgtgcaa
    21241 cgtggtgggg gcggcggtgg gcgcgcggat ggcgttgcgg cggggtgcgg ggttcgtgcg
    21301 ggtggtgctg ctggtggtgg tgctggcgtt ggtggcccgg ttgggttacg accagtggtt
    21361 ggcgggctga tcgcggtggc ggtgcgggcg gagcacgatc gggcggtgct ggcgggtctg
    21421 ctgggccggg atccggtgtt gcacgcgtac cagttgggtg atctggacga tttcttctgg
    21481 ccgtacacgt cgtggttccg gcgtggcgac caggtggtgt tgctgtatca cggggtggag
    21541 ttgccgacgt tgctggcgtt cgcggcgccg gatcgggtgc cggagttggc ggggttgctg
    21601 gcggaggcgg cgccggtgtt gccggcgcgg atgtgggcgc acctgtcccc cgggctggag
    21661 gcggtggtgg gccgctggtt cgtggtgtct gaggcggcgg cgcatcaccg gatggcgttg
    21721 acggatccgg gtcggttggc ggcggtgccg gcggtgggtg agccgttggg gccggcggac
    21781 gcggcggagc tttccgggtt gtacgcggtg gcgtatccgg ggaactggtt cgatccgcgg
    21841 atgctggaca cgggccagta cgtgggggtg cgggagcggg gccggttggt ggcggtggcg
    21901 ggggtgcacg tgttctcgcc gcggtggcgg gtggcggctt tggggaacgt gacgacgcat
    21961 ccggacgtgc ggggtcgggg tctgggcgcg ggggtggtgg cggcgttgtg cgcgcggctg
    22021 ctgacgttgg tggatcatgt gacgttgaac gtgcgggcgg acaacgcggc ggcggtgcgg
    22081 ctgtacgagc ggttggggtt ctcccgggtg gccgggttca ccgagtgcgc gttgacgtca
    22141 gcggccgcgg ctgggtgagt cgaatcggcc ggcgcggatc tcgcgcaggg cccggcgacg
    22201 ggtgtcgccg cgcagggtgt cgacgtagag gcgtccgcgc aggtggtcgg tctcgtgttg
    22261 cagggcgcgg gcgaggaagc cgctgccggt gatggtgagg ggttcgccgt gctggtcgta
    22321 gccgtgggcg gtggcgtgca gggcgcgggg ggtcgggaag tacaggccgg ggatggacag
    22381 gcagccctcg tcgtcgtcct ggagttcgtc ggacagttcc aacgtggggt tgatcatgtg
    22441 gccgcgccgg ccgtcggcgt cgtagacgaa cacctgggcg ttgacgccga tctggggcgc
    22501 ggcgacgccg gcgcgtccgg gcgcgccgag cagggtgtcc atcaggtcgg tgacgagggc
    22561 gcgcagttcg gcgtcgaagc tggtgacggg ttcgctgggg gtgcgcagca cggggt
//
