LOCUS       NZ_CP094483            11305 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces murinus strain JS029 chromosome.
ACCESSION   NZ_CP094483
VERSION     NZ_CP094483.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces murinus
  ORGANISM  Streptomyces murinus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303622)
  AUTHORS   Chi,W.-J., Kim,K.-T., Park,S.-Y. and Kim,S.
  TITLE     Draft genome sequence of Streptomyces sp. JS029
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303622)
  AUTHORS   Chi,W.-J., Kim,K.-T., Park,S.-Y. and Kim,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAR-2022) Agricultural Life Science, Sunchon National
            University, Jungangro 255, Suncheon, Jeonnam 57922, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 16-MAR-2021
            Assembly Method                   :: Unicycler v. 0.3.1
            Assembly Name                     :: JS029
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 164.82x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028753175.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 03:30:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,582
            CDSs (total)                      :: 7,481
            Genes (coding)                    :: 7,273
            CDSs (with protein)               :: 7,273
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 215
            CDSs (without protein)            :: 208
            Pseudo Genes (ambiguous residues) :: 0 of 215
            Pseudo Genes (frameshifted)       :: 110 of 215
            Pseudo Genes (incomplete)         :: 125 of 215
            Pseudo Genes (internal stop)      :: 20 of 215
            Pseudo Genes (multiple problems)  :: 41 of 215
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:08:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1803010
            Orig. end                         :: 1814315
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094483.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from National Institute of
            Biological Resources.
FEATURES             Location/Qualifiers
     region          1..11305
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11305
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11305
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6305](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6305
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(310..462)
                     /locus_tag="ME763_RS07690"
                     /old_locus_tag="ME763_07685"
     CDS             complement(310..462)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ME763_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ME763_07685"
                     /product="hypothetical protein"
                     /protein_id="WP_172427670.1"
                     /transl_table=11
                     /translation="MSRKQKAVVIMVAALAAQAYLGKVAKQQGAALGLPVLAGSAIGYV
                     TSAAL"
     gene            complement(666..920)
                     /locus_tag="ME763_RS07695"
                     /old_locus_tag="ME763_07690"
     CDS             complement(666..920)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ME763_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ME763_07690"
                     /product="hypothetical protein"
                     /protein_id="WP_143657412.1"
                     /transl_table=11
                     /translation="MITWKGDAIGIPPTPTLWRPVAPHGSIFGIELELSIRDRWLADGA
                     QEADQFGQTSPVNMPEIGVALIVGTFVMVALMALGILLR"
     misc_feature    complement(870..872)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(926..944)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.86"
                     /tool="antismash"
     misc_feature    1162..1177
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(1249..1680)
                     /locus_tag="ME763_RS07700"
                     /old_locus_tag="ME763_07695"
     CDS             complement(1249..1680)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143004.1"
                     /locus_tag="ME763_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07695"
                     /product="hypothetical protein"
                     /protein_id="WP_085567095.1"
                     /transl_table=11
                     /translation="MVDTPPGETYAEIAARHGRAETTVRNQWGRHPQWPDPLPEKRGRF
                     LQFGPAAVDRFVAEHVDRQGAELEPRRLYAAREIEQLTGITAATIRADRSKGRWPEPDD
                     SSSRAHRWYGATVTKVLSGRRGYRRDGAGEHPKHPTPAN"
     gene            complement(1877..2209)
                     /locus_tag="ME763_RS07705"
                     /old_locus_tag="ME763_07700"
     CDS             complement(1877..2209)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ME763_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ME763_07700"
                     /product="hypothetical protein"
                     /protein_id="WP_085567094.1"
                     /transl_table=11
                     /translation="MSGEFEREAQGLGNAILMVYVPIARVCGLLPILISLLFEEADPLH
                     GEGVIAAVIRVTNLIEDEPIDEILQAGVWGGRLHWFSAAHLFIRYMEASECIVGQEIRN
                     DLATQR"
     misc_feature    2356..2370
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     misc_feature    complement(2362..2377)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.45"
                     /tool="antismash"
     misc_feature    2377..2395
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.72"
                     /tool="antismash"
     gene            complement(2382..2561)
                     /locus_tag="ME763_RS07710"
                     /old_locus_tag="ME763_07705"
     CDS             complement(2382..2561)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ME763_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ME763_07705"
                     /product="hypothetical protein"
                     /protein_id="WP_274506104.1"
                     /transl_table=11
                     /translation="MTRPRSLPADVPPSERAEPERYLAADIAAAVGVPVSDLPGTRLTA
                     EVSADGRLSSWRRA"
     gene            complement(2629..4020)
                     /locus_tag="ME763_RS07715"
                     /old_locus_tag="ME763_07710"
     CDS             complement(2629..4020)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845055.1"
                     /locus_tag="ME763_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07710"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_337999695.1"
                     /transl_table=11
                     /translation="MAHLADADRDAYLASLAPGADINHCGTPFTEQLLTDLLTALRDPS
                     TGEPHLGSALFIGVQFSGDAWFTGAQFSGDAWFGGAQFEGVSLFGPLVCAGTVVLSRAV
                     FGLPVTLEIAAEEVVAERTRWESTADIRLRYATVDLSQAVLSAPTAVTAAATPFSDPSE
                     NARGEQALTGSADVRVASVQGADAAHLVLTDTDLTDCLFSGAFHLDQLRLEGRTTFAPT
                     PTGWHRHYLWPTRWTRRRTLAEEHHWRAQIANQPSPAPGVPPSSHSWRPGPHHPDPART
                     PDPEDIAALYRQLRKAFEDSKNEPGAADFYYGECEMRRHDRTGTPPGERRLLWGYWLLS
                     GYGLRASRAMGWLVAAMSLTVLLLMGFGLPSHDPEPATTGTLYGSKISLNTSTPDPSLR
                     GGLDERMTWVRAEKATHVAVNSVLFRSSGQNLTTLGTYIEMVSRLLEPTLLALAALAVR
                     GRIKR"
     misc_feature    4038..4049
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    4143..4157
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.09"
                     /tool="antismash"
     gene            complement(4258..4419)
                     /locus_tag="ME763_RS07720"
                     /old_locus_tag="ME763_07715"
     CDS             complement(4258..4419)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ME763_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ME763_07715"
                     /product="hypothetical protein"
                     /protein_id="WP_274506105.1"
                     /transl_table=11
                     /translation="MLILDEMRQALAVLRATRGAPDTAKQNEAAARAAIRAVADSALDV
                     QRSQRTCS"
     gene            4412..4828
                     /locus_tag="ME763_RS07725"
                     /old_locus_tag="ME763_07720"
     CDS             4412..4828
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="ME763_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07720"
                     /product="MFS transporter"
                     /protein_id="WP_274506106.1"
                     /transl_table=11
                     /translation="MSTRLRWKPYRLLAVAVVAGGGLALPPAAMAWGLPLPVVLVAAFL
                     AGVGLDVAIVAWTTAFQQHVPSAEQGRMSAFNGAGERLAIPLGYLITALAVHAWSSQGV
                     LLACAALIVAATVLNLCVPDLHRVNRVRREADPA"
     misc_feature    4918..4927
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            5001..6305
                     /locus_tag="ME763_RS07730"
                     /old_locus_tag="ME763_07725"
     CDS             5001..6305
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327585.1"
                     /locus_tag="ME763_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07725"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_085567091.1"
                     /sec_met_domain="DUF692 (E-value: 8.1e-97, bitscore: 322.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLGTGIGWRPEIAEAVERMPGIDWVEVVAENVCPGHLPEPLER
                     LRARGVTVVPHGVSLGLGGAQRPDAGRLTALAERAQALGSPLVTEHIAFVRAGGALTAS
                     PLLEAGHLLPVPRTRDALDVLCANVRIAQDALPVPLAVENIAALFSWPDEELTEGQFLY
                     ELAERTGVRLLIDVANLHTNHVNRGEDPAEALAGLPLEAIAYVHVAGGVERDGVWHDSH
                     AHPVPDAVLGILADLAARAAPPGVLLERDENFPEPAELERELDAIRKVVEGGRRGDAEV
                     RPVSPVRTDPGDTEGARQRLGVAQTAVLSSLVARTPVPEGFDRVRLGVQARALAAKRAD
                     VVAKVAPELPALLGASYREAFLEYARARPMRGGYRRDALDFAGFLLDGKRTDLPRRELR
                     EWWLDRSGPAPRGRVARAARRVLLGRVRNTPPVRA"
     gene            6441..7226
                     /locus_tag="ME763_RS07735"
                     /old_locus_tag="ME763_07730"
     CDS             6441..7226
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675656.1"
                     /locus_tag="ME763_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07730"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_085567090.1"
                     /transl_table=11
                     /translation="MFWLLLLLLAWAFTGTACVRLCLAAMRAAATDPGPDPGGVVKDHD
                     LTLYEAAFLSGGPQRVADVTLLSMARQRRLHLAHTGWATVVDPLGRDEIERSVIGAIGP
                     EGQSRIAPVRTRAAHTDAVRRLADRLVRSGLAVPDAAGPTIAAAVRQVRAAALAVPVLA
                     VTALLMPIQADTSRLMVGLWFLLPFTLSLSCLAIARFEVHPYSPWASPAGQRVLGALLR
                     RRSGDEPSFLTSVALRGIRAIGEPELRAAFAHRDAPHRE"
     misc_feature    complement(7286..7300)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.29"
                     /tool="antismash"
     gene            7335..8987
                     /locus_tag="ME763_RS07740"
                     /old_locus_tag="ME763_07735"
     CDS             7335..8987
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (130-503). E-value:
                     3.2e-16. Score: 51.6. Matches aSDomain:
                     nrpspksdomains_ME763_RS07740_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657156.1"
                     /locus_tag="ME763_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07735"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_085567089.1"
                     /sec_met_domain="PF00561 (E-value: 6e-20, bitscore: 70.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVAVCSAAVSLLLTTLATAPVDATPAIPAALSLPAPPSLPGVP
                     FPSGAAELRGTIVAALRARATGPHYGTCDPAEVPPVAHSPAGLRCGTVSVPLDYAHPDG
                     KQIALTVSRAPATGKDGERKVPRQGALVYDPGGPGASGMYFALAGTLPVWKRIAAAYDL
                     VGYAPRGVGRSAPLSCEDPKQFGKAPTLAPTRPSESYKRERVAEAKAYARGCARRSGPG
                     LRFFNSLNNARDLDVLRAALGEDRLTFLGASYGTYYGSLYAAMFPSHVRRMVLDAAVNP
                     DPERIWYRGNLDQSAAFEKRWADVRDWIARHDDVYRLGATPQKVQGSYDTAAARLARRP
                     AGGKVGPGQLQNAFLTAGYYDSSWPSRAAALSAYLHGDPKPLVHLAAPDPASAAAAENG
                     TAVYTAVECNDAPWPTRWAVWDRDNTRLARVAPFETWDNAWMNLPCAYWPAPRQRPLDV
                     RTAPGALPPVLILAAERDAAAPYSGALEMNRRLAGSLLVTERGAGTHGIGGGPNKCVNG
                     YLDDYLLTGRLPARNASCAPRAEPVPGRGRTAG"
     aSDomain        7725..8843
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ME763_RS07740_Abhydrolase_1.1"
                     /evalue="3.20E-16"
                     /label="ME763_RS07740_Abhydrolase_1.1"
                     /locus_tag="ME763_RS07740"
                     /protein_end="503"
                     /protein_start="130"
                     /score="51.6"
                     /tool="antismash"
                     /translation="LVYDPGGPGASGMYFALAGTLPVWKRIAAAYDLVGYAPRGVGRSA
                     PLSCEDPKQFGKAPTLAPTRPSESYKRERVAEAKAYARGCARRSGPGLRFFNSLNNARD
                     LDVLRAALGEDRLTFLGASYGTYYGSLYAAMFPSHVRRMVLDAAVNPDPERIWYRGNLD
                     QSAAFEKRWADVRDWIARHDDVYRLGATPQKVQGSYDTAAARLARRPAGGKVGPGQLQN
                     AFLTAGYYDSSWPSRAAALSAYLHGDPKPLVHLAAPDPASAAAAENGTAVYTAVECNDA
                     PWPTRWAVWDRDNTRLARVAPFETWDNAWMNLPCAYWPAPRQRPLDVRTAPGALPPVLI
                     LAAERDAAAPYSGALEMNRRLAGSLLVTERGAG"
     gene            complement(8991..9722)
                     /gene="hemQ"
                     /locus_tag="ME763_RS07745"
                     /old_locus_tag="ME763_07740"
     CDS             complement(8991..9722)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564417.1"
                     /locus_tag="ME763_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07740"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_085567088.1"
                     /transl_table=11
                     /translation="MSDDAPTTESGRIPNKGKLAKDLNDVIRYTLWSVFKLKDVLPADR
                     AGYADEVQELFDQLAAKDVTIRGTYDLSGMRADADVMIWWHAETSDQLQEAYSLFRRTK
                     LGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRDYVSVYPFVRSYDWYLLPDEDRRR
                     MLADHGKMARGYPDVRANTVASFSLGDYEWILAFEANDLSRIVDLMRHLRGSEARMHVR
                     EEVPFYTGRRKDVADLVAGLA"
     gene            complement(9728..11182)
                     /gene="hemG"
                     /locus_tag="ME763_RS07750"
                     /old_locus_tag="ME763_07745"
     CDS             complement(9728..11182)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981981.1"
                     /locus_tag="ME763_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_07745"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_085567087.1"
                     /sec_met_domain="DAO (E-value: 5.3e-07, bitscore: 28.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATGTSSGHAVVIGAGVAGLAAAHRLLERGARVTVLEASERVGG
                     KLLPGEIAGVRVDLGAESMLARRPEAVALAREVGLDARLRTPAIASAAIWTRGALRPMP
                     KGHVMGVPGTAAALAGVLSEDGLARIEQDAVLPRTEVGDDVAVGEYVAARLGREVVDRL
                     VEPLLGGVYAGDAYRISMRSAVPQLFRAARAHASLTEGVREIQARAAANQQTGPVFMGI
                     EGGVGTLPLAVAESVRARGGEIHTGAPVTELRRDPAGGWRITAAGRQLHADAVVVAVPA
                     PAAARLLRPESPAAAAELAAVEYASMALITLAYRRADLSLPEGSGFLVPPVDGRTIKAA
                     TFASQKWGWIAEQDPDTVVLRTSVGRYGETAVLGRDDADLVQVSRHDLREAVGIEAAPV
                     ETRVTRWTDGLPQYPVGHHGRVARIREHIAKLPGLAVCGAQYDGVGIPACVASANAAVD
                     QLSGDLRGVEELTAHPVQSLHGGAGE"
ORIGIN
        1 taccaacgac gcggccacac accacccgaa cctgcccaac catcaggaaa agcaccgttg
       61 cagtactaag gccctcagct tccgctgtgg ccgaagcctt ctccctcaga tccttggcac
      121 actcggctat ccccttgtag agggctgcct gagcctcgtt cctggcgttg ctggtctcct
      181 ggtcgagcgg tattcgttct cctgactggt tctcatggtg gcattcgtta cgcctggcaa
      241 gctggtctct ggcacgcgcg gggccccggc ttcgccgatt cggccggcag agccggggcc
      301 cggcggcggc tacagagcag cgctggtgac gtagccgatc gcgctgccgg ccaggaccgg
      361 caggccgagc gcggcgccct gctgcttggc gaccttgccc aggtacgcct gcgcggccag
      421 ggccgcgacc atgatgacga ccgccttctg cttcctcgac attcttcacc tcctctccac
      481 actgtgctgg agggaaggac gacacgaggg tctgacaacg acccttcgat tgggagaagt
      541 tgtgggcagg ccgggattca acccctcccg ggcgcacggg ttcgcgcggt ccacccggaa
      601 cgcgggcggt gtacggccgc ccggcacgcc tgcccgttca agggatcggc gccagcgtac
      661 gccggtcagc gcagcaggat gccgagagcc atcagcgcga ccatgacgaa ggtgccgacg
      721 atgagggcga cgccgatctc aggcatgttc acaggactcg tctgcccgaa ctgatcagct
      781 tcttgcgcgc catccgcaag ccaacgatca cgaattgaca attcaagttc aattccgaat
      841 atcgagccgt gtggcgccac ggggcgccat aacgtcggcg tcggcggtat cccgatggca
      901 tcgcccttcc acgtgatcac ggaagggagg tgagccgtgc ctgaatgggg agaaccgccg
      961 gactatgcgt acctgtgtct cctggtcgag atagcccagc tgttggtgca aatcgttcag
     1021 ctggtcatgc caggccacgc ctagtccggc ggtagtcgct gtggggctgc gggccagttg
     1081 gttcgcagcc ccttctcacg ttgcacctac cccaccctaa cgaatccata gatgcgctcg
     1141 atgtgacacg agattagcgc ctccaggatt tgttcgcagc aggattcgtt aaatcatccg
     1201 cgataatttc gcagcaatct gcgatcaatt gagtgtacga ccgttcactc aatttgcggg
     1261 ggtggggtgt ttggggtgtt cacccgcgcc gtctcgtcgg tagccacgac gcccggagag
     1321 caccttcgtg acggtggcgc cgtaccagcg gtgtgcgcgg ctagaactgt cgtccggttc
     1381 gggccagcgc cccttggagc ggtcggcgcg gatggtggcg gccgtgatgc cggtcagctg
     1441 ctcgatctcg cgggcggcgt agagccgccg gggctccagc tcggcgccct ggcggtcgac
     1501 atgttcggcg acgaagcggt ccacggcggc cgggccgaac tggaggaacc ggccgcgctt
     1561 ctcgggcagc ggatctggcc attgagggtg acggccccac tggttgcgga cggtggtctc
     1621 ggcgcggccg tggcgggcag cgatctcggc atacgtctcg ccgggcggag tgtctaccat
     1681 gggggtgtcc gtccttcgtg gatggttggt gaccggtagg ggttttccgg cgggcgtccg
     1741 cgcctgtggg cttcggcccg gcccctgccg gtctctttcg ttgtacgggt gaggcccccg
     1801 gctggatgcc gggggcctcg gctgtggtta cccctccggg gagtccatca actggtgagc
     1861 cacggtgtgg agcacctcac cgctgggtcg ccaggtcgtt cctgatctct tggccgacga
     1921 tgcactcgct ggcctccatg tacctgatga acaggtgcgc tgcggagaac cagtggaggc
     1981 gcccgcccca gacaccggcc tggagaatct catcgatcgg ctcgtcctcg atgaggttgg
     2041 tgacccggat cactgcggcg atcacgccct cgccgtgaag ggggtcagct tcctcgaaga
     2101 ggaggctgat caggatcggg aggagcccgc agaccctggc gatcgggacg tagaccatga
     2161 ggatggcgtt ccccagcccc tgggcctccc gctcgaactc gccggacatg ctgtccgtcc
     2221 tctcttgaat tgtggtggct ggtgaaggaa ttcggggttt ccggcccctc gtcccttcca
     2281 tctccatcat ggacctttcg cgcactgatt tgcaacactt ctgagcaagg gattggcacc
     2341 ccaacttcca tagatattag ggctgttgat tgtcagtcag gtcaggcgcg ccgccagctt
     2401 gacaggcggc cgtccgcgct gacctcggcc gtcagccgcg tgccgggcag gtcactgacc
     2461 ggaacgccga ccgccgcagc gatgtcggcg gccagatacc gctccggttc ggcgcgctcg
     2521 gacggcggga cgtccgcggg caacgatctc ggcctggtca ccgaacaaca gcaagacgcg
     2581 aacggtgaca cgctcggcag tcatgtggat caccctctcg tgtggaggtc agcgtttgat
     2641 tcggccacgc acggcgagtg cggccagcgc caggagcgtg ggctccagca ggcgggagac
     2701 catctctatg tacgtgccca gggtggtgag attctggccg gaagatcgaa agagcactga
     2761 attgacggca acgtgtgtgg ccttctcagc gcgcacccat gtcatgcgtt catccaagcc
     2821 gccgcgcaga gaggggtctg gtgtgctggt gttgaggctg atcttgctgc cgtaaagggt
     2881 gccggtagtg gccggctctg ggtcgtggct gggcagccca aaccccatga ggagcagcac
     2941 agtcagagac atagcggcca cgagccagcc catggctcgg gaggcacgca ggccgtagcc
     3001 ggacaacagc cagtagcccc agagcaagcg acgttcgccg ggcggggtgc cggtgcggtc
     3061 gtggcggcgc atctcgcact cgccgtagta gaagtcagcg gcgccgggtt cgttcttact
     3121 gtcttcgaac gctttgcgga gctgccgata gagagcggcg atgtcctcgg gatcaggcgt
     3181 acgtgcgggg tcagggtggt gtgggccagg tcgccatgag tgagaggatg gaggaactcc
     3241 aggggcaggc gagggttggt tagcgatctg ggcgcgccag tggtgttcct cagcgagggt
     3301 acgccgacgg gtccagcgtg ttggccacag gtagtgacgg tgccatcccg tgggcgtggg
     3361 ggcgaaggtg gtgcgtccct ccaggcgcag ctggtcgagg tggaaggctc cggagaaaag
     3421 gcagtcggtc aggtcggtgt cggtcaggac cagatgtgcg gcgtccgctc cctgcactga
     3481 agcaacccgg acgtcggcag atccagtcaa cgcctgctcg ccccgagcat tctcggaggg
     3541 atcgctaaag ggagttgcgg cggccgtgac cgccgtggga gcggacagca ccgcctggct
     3601 gaggtccacg gtcgcgtacc gcaggcgaat gtccgccgtc gactcccacc gcgtccgctc
     3661 ggccaccacc tcctccgctg caatctccaa cgtgaccggc agcccgaaga ccgccctaga
     3721 cagcaccacc gtccccgcgc acaccagcgg cccgaacagc gacacaccct caaactgcgc
     3781 cccgccgaac caggcgtcgc cggagaactg cgccccggtg aaccaggcgt caccggagaa
     3841 ctgcaccccg atgaacaggg cgctgccgag gtgtggctcg ccggtgctgg ggtcgcggag
     3901 ggcggtaagg aggtcggtaa gcagttgttc ggtgaaaggg gtgccacagt ggttgatgtc
     3961 ggcgccgggg gccaggctgg ccaggtaggc gtctcggtca gcatccgcca ggtgtgccaa
     4021 gcacaaggtg tggccaggga cgtgaacgcc gcggcaaccg atcggatcgg tgtccgaagg
     4081 ggtacggtat ccgcaatatg gccacgaagg cgcggcatgg gttggcggcg gggatgttgt
     4141 catgggagcg gctccaggcg tgatgcgtca cgatgcggca aggtccctca ggatggacgg
     4201 cgccacgtga tctgccggtt gcgaaggaac cggtttcaga catcgttggg ccctgattca
     4261 tgaacaggtt cgctgacttc gctgaacgtc gagggcgctg tccgctacgg cccggatggc
     4321 agcgcgcgcg gcggcctcgt tctgcttggc ggtgtccggt gcgccgcggg tggcgcgcag
     4381 cacggcgagg gcctggcgca tctcgtccag gatgagcacg aggctgcgct ggaagccgta
     4441 ccggctgctc gcggtcgcgg tcgtcgcggg cggcgggctc gcgctgccgc cggcggccat
     4501 ggcctggggc ctgccgctgc cggtcgtcct cgtggccgca ttccttgcgg gggtcgggct
     4561 cgatgtcgcg atcgtcgcct ggaccaccgc gttccagcag catgtgccct cggcggagca
     4621 gggccgtatg agcgcgttca acggtgccgg cgaacggctc gccatccccc tcggctatct
     4681 catcaccgcc ctcgcggtgc acgcgtggag cagccagggc gtgctcctgg cctgcgccgc
     4741 gctgatcgtc gcggcgaccg tgctcaacct ctgcgtcccg gatctgcatc gcgtcaaccg
     4801 cgtccgccgg gaggccgacc cggcctgaaa cccggcgagg agcttcgcgt gcggcccggc
     4861 ctgaaacccg cttcgaagcc cggccaaaaa cccggcgcga acctcaaatg ttgctctgaa
     4921 ggcggccggg agggggttcg gggcgcgccg ccggggtcat gtacgacgcg tgcgccgggg
     4981 ggcgaggagg gggacaggtc atggggagac tggggacggg gatcggctgg cggccggaga
     5041 tcgccgaggc cgtggagcgg atgcccggga tcgactgggt ggaggtcgtg gcggagaacg
     5101 tctgccccgg ccatctcccc gagccgctgg agcggttgcg ggcgcgcggg gtgaccgtgg
     5161 tgccgcacgg tgtctccctc gggctcggcg gcgcgcagcg gcccgacgcc ggccggctca
     5221 cggcgctcgc cgaacgcgct caggcgctcg ggtcgccgct ggtcaccgag cacatcgcgt
     5281 tcgtcagggc gggcggcgcg ctcaccgcgt cgccgctgct ggaggcgggc catctgctgc
     5341 ccgtgccgcg cacccgggac gcgctcgacg tgctctgcgc gaacgtgcgc atcgcccagg
     5401 acgcgctgcc ggtgccgctc gccgtggaga acatcgccgc gctgttctcc tggccggacg
     5461 aggagctgac cgaggggcag ttcctgtacg agctggccga gcggaccggc gtacggctgc
     5521 tgatcgacgt ggccaatctg cacaccaacc acgtcaaccg cggcgaggac ccggccgagg
     5581 cgctggccgg gctgccgctg gaggcgatcg cctacgtcca tgtcgcgggc ggcgtcgagc
     5641 gcgacggcgt gtggcacgac agccacgcgc atccggtgcc ggacgcggtg ctcggcatcc
     5701 tggccgacct cgccgcccgg gccgccccgc ccggcgtcct gctggaacgc gacgagaact
     5761 tccccgaacc ggccgagctg gagcgcgagt tggatgcgat ccggaaggtg gtggagggcg
     5821 gccgacgggg ggatgcggaa gtgcggcccg tatcgccggt gcgcacggac ccgggcgaca
     5881 ccgagggcgc ccgtcagcgg ctcggggtcg cgcagaccgc cgtgctgtcc tcgctggtgg
     5941 cccggacgcc cgtgcccgag gggttcgacc gggtacggct gggtgtgcag gcgcgggcgc
     6001 tcgctgcgaa gcgggcggac gtggtggcga aggtggcgcc ggagctgccg gcgctgctgg
     6061 gggcgtcgta ccgggaggcg ttcctggagt acgcacgggc acggccgatg cgtggggggt
     6121 accggcggga cgcgctggac ttcgccgggt tcctgctgga cggaaagcgg acggacctcc
     6181 cgaggcggga gctgcgggag tggtggcttg accgctccgg cccggcgccc cgagggcggg
     6241 tggcgcgggc ggcgcggagg gtgctgctgg ggcgcgtccg aaacacaccg cccgtacgcg
     6301 cctgaagcac cccatccaca tcgcctgaag catgtcgtcc gtacgcgcct gaagcgcgcc
     6361 gtccgtacgc gcctgaagca ccccgtccgc atgtgaaaat tcctggcggc cgaccccacc
     6421 cctgacatac aaaacagctc atgttctggc tcctcctcct gctcctcgcc tgggcgttca
     6481 ccggcacggc ctgcgtccgt ctctgtctcg cggcgatgcg cgccgcggcc acggacccgg
     6541 gcccggaccc cggaggagtg gtcaaagacc atgatctgac cctgtacgag gccgcgttcc
     6601 tgtccggcgg accccagcgc gtcgccgatg tcaccctcct gtcgatggcc cgccagcggc
     6661 gcctgcacct cgcccacacc ggctgggcca ccgtcgtcga cccgctcggc cgggacgaga
     6721 tcgagcggtc cgtcataggg gcgatcggcc ccgagggcca gtcccgcatc gcgcccgtgc
     6781 ggacccgcgc cgcccacacc gacgccgtac gacgcctcgc cgaccgcctc gtgcgcagcg
     6841 gcctcgccgt cccggacgcc gcgggcccca ccatcgccgc ggccgtgcgc caggtccgcg
     6901 ccgccgcgct cgccgtgccg gtcctcgccg tcaccgcgct gctgatgccg atccaggccg
     6961 acacctcacg gctgatggtc ggcctgtggt tcctgctgcc gttcacactg tcgctgagct
     7021 gtctggccat cgcccgcttc gaggtgcacc cgtactcgcc ctgggcctcc cccgccgggc
     7081 agcgcgtgct gggcgcgctg ctgcggcggc gctccggtga cgagccgtcg ttcctcacct
     7141 ccgtcgcgct gcgcggcatc cgcgcgatcg gcgagccgga gctgcgcgcg gccttcgccc
     7201 accgcgacgc gccacaccgg gagtaggggg cgcatcgggg cacccgcgcc gacacccgcc
     7261 gggcggtgct tgccttcccc ggcgggggaa cgaaacatcc ctggtgtccg cctcggtgac
     7321 cgaagggatg ccggatgaaa gccgtcgctg tctgctcggc cgccgtctcg ctgctgctga
     7381 ccaccctggc caccgccccg gtggacgcca cgccggccat ccccgccgcg ctgagcctcc
     7441 ccgccccgcc gagcctcccc ggcgtgccgt tcccctccgg cgccgccgaa ctccgcggca
     7501 ccatcgtcgc cgccctccgc gcccgcgcca ccggcccgca ctacggcacc tgcgaccccg
     7561 ccgaggtgcc accggtcgcc cactcccccg ccggactgcg ctgcggcacc gtctccgtgc
     7621 ccctcgacta cgcccacccc gacggcaaac agatcgcact caccgtcagc cgggcccccg
     7681 ccaccgggaa ggacggcgag cggaaggtcc cccggcaggg cgccctcgtc tacgacccgg
     7741 gcggccccgg cgcctccggc atgtacttcg cgctggccgg caccctgccc gtctggaagc
     7801 ggatcgccgc cgcctacgac ctggtcggct acgccccgcg cggggtgggc cgctccgcgc
     7861 cgctgtcctg cgaggacccg aagcagttcg gcaaggcgcc cacgctcgcg ccgacccggc
     7921 cctcggagtc gtacaaacgc gagcgcgtgg cggaggcgaa ggcgtacgcc cgcggctgcg
     7981 cccggcgttc gggccccggg ctgcgcttct tcaactccct gaacaacgcg cgggacctgg
     8041 acgtcctgcg ggccgcgctg ggcgaggacc ggctgacgtt cctgggcgcg tcgtacggca
     8101 cgtactacgg ctcgctgtac gcggcgatgt tcccctccca tgtccgccgg atggtgctgg
     8161 acgcggcggt gaacccggat ccggagcgga tctggtaccg cggcaacctc gaccagtcgg
     8221 ccgcgttcga gaagcgctgg gcggatgtgc gggactggat cgcccggcac gacgacgtgt
     8281 accggctcgg cgccacgcca cagaaggtgc aggggagtta cgacaccgcc gccgcgcggc
     8341 tggcccggag accggcgggc gggaaggtcg gccctggcca gttgcagaac gcgttcctga
     8401 cggccgggta ctacgactcc tcctggccga gccgggccgc cgccctctcc gcctatctgc
     8461 acggcgaccc gaagccgctg gtccacctgg ccgctccgga ccccgcgtcg gcggccgcgg
     8521 cggagaacgg caccgccgtg tacaccgccg tcgagtgcaa tgacgcgccc tggcccacgc
     8581 gttgggcggt gtgggaccgg gacaacaccc ggctggcccg cgtcgcgccc ttcgagacct
     8641 gggacaacgc gtggatgaac ctgccctgcg cgtactggcc cgcgccccgg cagcggcccc
     8701 tggacgtgcg caccgcgccc ggcgcgctgc ccccggtgct gatcctggcg gccgaacggg
     8761 acgcggccgc gccgtactcg ggggccctgg agatgaaccg gcggctggcc ggctccctgc
     8821 tggtgaccga gcgcggcgcg ggcacgcacg gcatcggcgg cggccccaac aaatgcgtca
     8881 acggctatct ggacgactat ctgctgacgg gccgcctccc ggcgcggaac gcgtcctgcg
     8941 cgccccgcgc cgaacccgtc cccggccggg gacggacggc gggctgagcc ttacgccagc
     9001 cccgccacca ggtccgccac gtccttgcgg cggcccgtgt agaacgggac ctcctcgcgg
     9061 acgtgcatcc gggcctcgga gccgcgcaga tggcgcatga ggtcgacgat gcgggacagg
     9121 tcgttcgcct cgaaggcgag gatccactcg tagtcgccca gcgagaagga ggcgaccgtg
     9181 ttggcgcgca cgtccgggta accgcgggcc atcttgccgt ggtcggcgag catccggcgg
     9241 cggtcctcgt cgggcagcag gtaccagtcg tacgagcgca cgaaggggta gacgctcaca
     9301 tagtcgcggg gcgtctcgtc ggcgaggaac gccgggatgt gcgagcggtt gaactcggcc
     9361 gggcggtgca gcgccatgtt ggaccacacc ggctccagcg cgcggcccag cttggtgcgg
     9421 cggaagaggc tgtacgcctc ctggagctgg tcgctggtct ccgcgtgcca ccagatcatc
     9481 acatcggcgt cggcccgcat accggacagg tcgtacgtgc cgcggatcgt cacgtccttg
     9541 gcggcgagct ggtcgaacag ctcctggacc tcgtcggcgt agcccgcgcg gtcggccggc
     9601 agcacgtcct tcagcttgaa gaccgaccac agggtgtagc ggatgacatc gttcaggtcc
     9661 ttggccagct tgcccttgtt ggggatcctg ccggactcgg tggtgggggc gtcgtcactc
     9721 atggttccta ttctcctgct ccgccgtgaa ggctctgcac cgggtgggcc gtcagctcct
     9781 cgaccccgcg cagatcaccg gacagctggt cgacggccgc gttcgcgctc gcgacacacg
     9841 cggggatgcc cacgccgtcg tactgcgcgc cgcagaccgc gaggcccgga agtttggcga
     9901 tgtgctcgcg gatccgggcc acccgtccgt ggtgcccgac cgggtactgc ggcagtccgt
     9961 cggtccagcg ggtgacccgg gtctcgaccg gcgcggcctc gataccgacg gcctcgcgga
    10021 ggtcgtgccg ggagacctgc accaggtcgg cgtcgtcccg gccgaggacc gccgtctcgc
    10081 cgtaccgccc caccgaggtg cgcagcacga ccgtgtccgg gtcctgctcg gcgatccagc
    10141 cccacttctg ggaggcgaac gtggcggcct tgatggtgcg tccgtcgacc ggcggcacca
    10201 ggaagccgct gccctcgggc agggacagat cggcgcgccg gtaggcgagg gtgatcaggg
    10261 ccatcgaggc gtactcgacg gcggccagtt cggcggcggc ggccggggac tcgggtcgca
    10321 gcagccgggc ggcggccggg gcgggtacgg cgaccaccac ggcgtcggcg tgcagttgcc
    10381 gcccggccgc ggtgatccgc cagccgcccg cggggtcccg gcgcagctcg gtgacgggtg
    10441 ccccggtgtg gatctcgccg ccgcgcgccc ggacggactc ggcgaccgcg agcggcaggg
    10501 tgcccacgcc gccctcgatg cccatgaaca cgggcccggt ctgctggttg gcggccgccc
    10561 tggcctggat ctcgcggacg ccctcggtca gggaggcgtg cgcgcgggcg gcccggaaga
    10621 gctgggggac ggcggagcgc atcgagatgc ggtacgcgtc gcccgcgtac accccgccga
    10681 gcaggggttc gacgaggcgg tccacgacct cgcggccgag gcgcgccgcc acgtactccc
    10741 ccaccgccac gtcgtcgccg acctcggtgc ggggcaggac ggcgtcctgt tcgatgcggg
    10801 ccaggccgtc ctcggacagg acgccggcga gggcggcggc ggtgccgggc acgcccatca
    10861 catggccctt gggcatgggg cgcagcgcgc cgcgggtcca gatggcggcg ctcgcgatcg
    10921 ccggggtcct gagccgggcg tcgaggccga cctcgcgggc gagggccacg gcctcggggc
    10981 ggcgggcgag catcgactcg gcgccgaggt cgacccggac gcccgcgatc tcgccgggca
    11041 gcagtttgcc gccgacccgc tcggacgctt cgaggaccgt cacccgcgcg ccgcgctcca
    11101 gcagccggtg ggcggcggcc agaccggcga caccggctcc gatgacgacg gcgtgccccg
    11161 aactcgtacc cgttgcgctc atggtcccca ctctctcaga ccccactgac agcgctgata
    11221 gggccgtagg tcccgcgccg cgcgggagcc gggaccctct agcgtgtcct catgagcatg
    11281 catcaggggc gggagcggct ggtcg
//
