LOCUS       NZ_CP094483            10216 bp    DNA     linear   CON 27-MAR-2024
DEFINITION  Streptomyces murinus strain JS029 chromosome.
ACCESSION   NZ_CP094483
VERSION     NZ_CP094483.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces murinus
  ORGANISM  Streptomyces murinus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8303622)
  AUTHORS   Chi,W.-J., Kim,K.-T., Park,S.-Y. and Kim,S.
  TITLE     Draft genome sequence of Streptomyces sp. JS029
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8303622)
  AUTHORS   Chi,W.-J., Kim,K.-T., Park,S.-Y. and Kim,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAR-2022) Agricultural Life Science, Sunchon National
            University, Jungangro 255, Suncheon, Jeonnam 57922, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 16-MAR-2021
            Assembly Method                   :: Unicycler v. 0.3.1
            Assembly Name                     :: JS029
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 164.82x
            Sequencing Technology             :: PacBio; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028753175.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 03:30:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,582
            CDSs (total)                      :: 7,481
            Genes (coding)                    :: 7,273
            CDSs (with protein)               :: 7,273
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 215
            CDSs (without protein)            :: 208
            Pseudo Genes (ambiguous residues) :: 0 of 215
            Pseudo Genes (frameshifted)       :: 110 of 215
            Pseudo Genes (incomplete)         :: 125 of 215
            Pseudo Genes (internal stop)      :: 20 of 215
            Pseudo Genes (multiple problems)  :: 41 of 215
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:08:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 348410
            Orig. end                         :: 358626
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094483.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from National Institute of
            Biological Resources.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5216
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            358..942
                     /locus_tag="ME763_RS01450"
                     /old_locus_tag="ME763_01445"
     CDS             358..942
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978113.1"
                     /locus_tag="ME763_RS01450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01445"
                     /product="hydrolase"
                     /protein_id="WP_085568115.1"
                     /transl_table=11
                     /translation="MSLTTLDPRTALVVIDLQHGIVGSPTQPHSGADVLSRSVELAEAF
                     RARNLPVVLVRVSFAADFSDAMPGRTEQQGGGAAFPEGWDVIVDELTGHAGDIQVTKHN
                     WSALFGTDLDVQLRRRGVTQIVLTGIATSIGVESTARDAYAMGYHVTLATDAMADRDAA
                     THAHSVEKIFPRLGETGTTAEVLELLAKTHG"
     gene            complement(1063..1248)
                     /locus_tag="ME763_RS01455"
                     /old_locus_tag="ME763_01450"
     CDS             complement(1063..1248)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389406.1"
                     /locus_tag="ME763_RS01455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01450"
                     /product="hypothetical protein"
                     /protein_id="WP_085568114.1"
                     /transl_table=11
                     /translation="MIAQPTEKPDIPRTETGWAQAHDRRDRPDLGVRTCVPAVPDRTGT
                     WRPGNDPEDTIVRGED"
     gene            complement(1381..1749)
                     /locus_tag="ME763_RS01460"
                     /old_locus_tag="ME763_01455"
     CDS             complement(1381..1749)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983514.1"
                     /locus_tag="ME763_RS01460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01455"
                     /product="DUF6479 family protein"
                     /protein_id="WP_274505998.1"
                     /transl_table=11
                     /translation="MNTAMYEAATSRQVFGYVLILVAGVVLVGGLIWAFRLGFKVRQRE
                     PAPPLPEEQPKLPPTGPVRETSEMREPRDVPRTGEEGERLTPHQLDNIRSRRADDQRRP
                     RWSPGSSGSFGGGGGGRT"
     gene            complement(1866..2153)
                     /locus_tag="ME763_RS01465"
                     /old_locus_tag="ME763_01460"
     CDS             complement(1866..2153)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676680.1"
                     /locus_tag="ME763_RS01465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01460"
                     /product="hypothetical protein"
                     /protein_id="WP_085568112.1"
                     /transl_table=11
                     /translation="MAHTFEELVQKQRAADAAHTTVEELRETYGPPAERGMTGAQSGTY
                     ETALRAWRDLAREAQTALSEYAKDTGRSRADIEAEVERAAAAPGERPPTG"
     misc_feature    2137..2152
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.38"
                     /tool="antismash"
     gene            2430..4565
                     /locus_tag="ME763_RS01470"
                     /old_locus_tag="ME763_01465"
     CDS             2430..4565
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676671.1"
                     /locus_tag="ME763_RS01470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01465"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_085568912.1"
                     /transl_table=11
                     /translation="MSDGPGPARAAAAGTPPGEPVLSVALAAMMEEVHAHSGAVYLLRP
                     DEPVLEMAVHAGLPRAFAAPWERLGLGASVPVADAVRKRRLVWVGGEEEMAGHYPRIAV
                     VLPYPFALAALPLATAHEVYGAVFVTWPGSHPPELSTEERVRLTAACKRLALRLARAAK
                     ERRPLGRERDLLAAPGPEVAGTLGSVEAARMVARLPYGLASLDLHGRIGYVSPAAATLL
                     GKTPDELLGALPWIAVPWLNDPTYEDRYRAALLSQQPTSFVALRPPGDWLSFRLYPNLT
                     GLSVRIGRTHPMADVAPAAAPVEAGPSRLVTISQVLNLAGALTEAVGVRDVVRLVWDEL
                     APAVGCRALTIAAPQGGRLHLLGHRGYADPRTVERWEGLPLSERTPGMRALSSGVPAFF
                     ESREQLGRLYPEREESPDGFAAWAYLPLIASGRPVGTCVLAYAEPRLFPADERAVLTAL
                     GGLIAQALERAMLYDAEHQLAHGLQQALLPHSLALLPGVEAAARYLPATHGMEIGGDFY
                     DLVAARPLTAAVIGDVQGHNVTAAGLMGQLRTAVRAYTAVGQGPHEVMASTNRLLIDLG
                     VELFASCLYLRLDPAAGLAVMARAGHPPPLLRRPDGQVRVLDLAGGPLLGIDASAAYPT
                     TEVALAPGSVLVLYTDGLVESPGVDIEDALTELSARLAELGDLPLETLADELVRRSVPA
                     GARRDDVALLLLRARGD"
     misc_feature    4607..4621
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(4614..4628)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.78"
                     /tool="antismash"
     misc_feature    complement(4791..4806)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.91"
                     /tool="antismash"
     gene            5001..5216
                     /locus_tag="ME763_RS01475"
                     /old_locus_tag="ME763_01470"
     CDS             5001..5216
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="ME763_RS01475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01470"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_085568111.1"
                     /sec_met_domain="strepbact (E-value: 4.6e-33, bitscore:
                     112.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVQTAEIADAELDAVSGGLQVNALSTVTGAVNGIAPVSDL
                     ANTAIGTVEGVTGLNVAPVTGLVAGL"
     gene            5322..6128
                     /locus_tag="ME763_RS01480"
                     /old_locus_tag="ME763_01475"
     CDS             5322..6128
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="ME763_RS01480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01475"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_085568110.1"
                     /transl_table=11
                     /translation="MQVRQQALAKLQSPQELDLPVRLARPQGRLALGVTVAVMAAASVW
                     AVTGSVASTVSAGAILTHGQGSYVLQSPVAGQVTAVLARQGRQLPANAPVIKVRTPQGD
                     AVVRTVAAGRITTLAATIGQIVQTGTDVAAVEKVAHANDPLYATVYVPAENAAAIPAGA
                     AVDLTVSSVPAQRYGVLRGRVRSVDRAAQSAQSIAAFLGDSQLGRQFTKDGRPVAVTVE
                     LDKSRTAKSGYRWSTADGPPFRPDSMTLASASVRLADQHPVDWLLP"
     gene            6125..8350
                     /locus_tag="ME763_RS01485"
                     /old_locus_tag="ME763_01480"
     CDS             6125..8350
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="ME763_RS01485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ME763_01480"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_085568109.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.7e-38, bitscore:
                     130.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPQETRGRRRAAPARRPSPTSRTGTVRTPTVLQMEAVECGAA
                     ALAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDLAALAEVR
                     APAILFWEFNHYVVYDGTGRRLGRRGIHINDPAKGRRFVPLEEFDGSFTGVVLVLEPGA
                     DFTRGGRRPGVLGALPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQ
                     TSLLGVLFTSMAACVLLTLVLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFAQR
                     SPADLVQRLQSNDQVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTFLGIGVALLNI
                     VAMRLVVRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHAATL
                     EEQQRLGVPSAWLGVVAPTLATFNSALILWIGGLRAVEGHISVGLLVAFQALVTRFTAP
                     LTRLNGVAGRIQDFAADVARLKDVENFQADPLYARGGPGDETRRLRGHVELENVAFGYS
                     PLDKPLLSGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWDGVIRIDGRRLEDIP
                     RGALAASVSFVDQEVFLFEGSVRDNVALWDPSIPDEAVVEALKDAALYEVVARRPGGIH
                     GRVDQDGRNFSGGQRQRLEIARALVRGPSVLVLDEVTSALDAQTELVVMDNLRRRGCAC
                     VVIAHRLSTVRDSDEIVVLQHGTVVERGRHEELVARGGAYAALVRER"
     misc_feature    8434..8448
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    8638..8651
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.54"
                     /tool="antismash"
ORIGIN
        1 ctggccgccg ccgagggggt gcgcccgcag tccatggcca ccacgctggc cgggctggag
       61 cagcacggtc tgatccgccg ggcccccgac ccggacgacg gccgccgtca gctggtcacc
      121 ctgaccgacg ccggccgggc ccgtatcgag ggcaacaagc aggtgcgcga ggagtggctg
      181 gcgcgcgcct tccaggaccg gtacagcgac gaggaacggc agacgatcct ggcggcgctg
      241 gagctgatgc agcggctgtc acggccgtag ccaccgaacg aacacgcgaa accccgcaca
      301 cccctgaaca accctgaacc acccctgaaa caacccctcg aaaggcctga ccgactcatg
      361 tcgctcacca cgctcgaccc ccgtaccgcc ctcgtcgtga tcgacctcca gcacggcatc
      421 gtgggctccc ccacccagcc gcactcgggc gccgacgtgc tgtcccgctc ggtggaactg
      481 gccgaggcgt tccgcgcccg gaacctgccc gtcgtcctgg tccgggtgtc cttcgccgcc
      541 gacttctccg acgccatgcc cggccgcacc gagcagcagg gcggcggcgc ggccttcccc
      601 gagggctggg acgtcatcgt cgacgaactg accggccacg cgggcgacat ccaggtcacc
      661 aagcacaact ggagcgccct gttcggcacc gacctggatg tgcagctgcg ccgccgcggt
      721 gtcacccaga tcgtgctgac cggcatcgcc accagcatcg gcgtcgagtc caccgcgcgt
      781 gacgcctacg ccatgggcta ccacgtcacc ctggccaccg acgcgatggc cgaccgcgac
      841 gccgccacgc acgcgcacag cgtcgagaag atcttcccgc ggctgggcga gaccggcacc
      901 acggcggagg tcctggagct gctggcgaag acgcacggct gaaccccggc tccggcgacg
      961 cacggctgaa acccgtggcc ggacatcgcg gcggcccggt tcccccgtcc gtgcggggag
     1021 ccgggccggt gcggtgtcca gggccgcggg tgtgccgtgc gctcagtcct cgccgcgcac
     1081 gatggtgtcc tcggggtcgt tgcccggccg ccaggtcccg gtgcggtccg gcacggcggg
     1141 cacgcaggta cgcaccccca ggtccggccg gtcccggcgg tcgtgcgcct gcgcccaccc
     1201 cgtctcggtc cgcggtatgt ccggtttctc ggtcggctgc gcgatcacgt cgtgtcatcc
     1261 accctctgcg tacggcggcc ggcgggcccg gcgtgtcggg ccccgcggac ctggtctgga
     1321 ctgtccgctg cgggtatccg cccggcgcgg cccgtaaacg ggagccgcgc ggcgggccgt
     1381 tcaggtacgg ccgccgccac cgccgccgaa ggacccgctg gaccccggtg accagcgcgg
     1441 acgccgctgg tcgtcggcgc gccgggagcg gatgttgtcg agctggtgcg gggtgagccg
     1501 ctcgccctcc tcgccggtcc tcggcacatc gcggggctcg cgcatctcgc tggtctcgcg
     1561 gaccgggccc gtcggcggca gcttgggctg ctcctccggg agcggtgggg cgggctcgcg
     1621 ctgacgcacc ttgaagccca gccggaacgc ccagatcagc ccgccgacca ggacgacccc
     1681 ggcgaccagg atgaggacgt agccgaagac ctgcctgctg gtggccgctt cgtacatggc
     1741 agtgttcatg gtcgccgggt acccggggcg ggccgacgaa taccggctcg cacatgggcc
     1801 tttccccggc cgccctgccg cctggccgcc ctgccgtccg ccaggccctc ggcccggcag
     1861 gactgtcagc ccgtcggcgg tctctccccc ggcgccgcgg cggcgcgttc cacctcggcc
     1921 tcgatgtcgg cgcgcgagcg gcccgtgtcc ttcgcgtact cgctcagcgc ggtctgcgcc
     1981 tcgcgggcga ggtcgcgcca ggcccgcagg gcggtctcgt aggtgcccga ctgggcgccg
     2041 gtcatgccgc gttcggccgg cggaccgtac gtctcgcgca gctcctcgac cgtggtgtgg
     2101 gccgcgtcgg ccgcccgctg cttctgcacc agttcctcga aggtgtgtgc caccccatcg
     2161 aatctaggcg cggtcccgtc ggcgcgcctg tccaacccgc aaccaagcgc tccgacacgc
     2221 ccgacgggct ccggtggccg gcgccgcggc tccgtcgctg ttcacgaggc gagtcgtacg
     2281 cgtcgcgccc tctccggcac cagggcgcgc cgtaccgtcc cccgggcggg tggcatgccg
     2341 ccgggggcgt gctcgccgtg cgccgggcgc cgtcacgggg gagtcttgat ccgggatgcg
     2401 acacgcggcc gtaggaggag gtggtcggcg tgtccgacgg gccagggccg gcacgggcgg
     2461 cggccgccgg gacacccccc ggtgagccgg tgctgtcggt cgccctggcc gcgatgatgg
     2521 aggaggtgca cgcccactcc ggcgccgtgt acctgctcag acccgacgag ccggtcctgg
     2581 agatggcggt gcacgcgggc ctgccccgcg cgttcgcggc gccctgggag cggctcgggc
     2641 tcggcgcgtc ggtgccggtc gcggacgcgg tgcgcaagcg gcgtctggtc tgggtgggcg
     2701 gcgaggagga gatggcgggg cactatccgc ggatcgcggt ggtgctgccg tacccgttcg
     2761 cgctggccgc gctgccgctg gcgaccgcgc acgaggtgta cggcgcggtg ttcgtgacct
     2821 ggcccgggag ccatccgccg gagctgtcca ccgaggagcg ggtccggctg acggcggcct
     2881 gcaagcggct ggcgctgcgg ctcgcccggg ccgcgaagga gcgcaggccg ctgggccgtg
     2941 agcgcgatct gctcgcggcg cccggacccg aggtggcggg caccctgggt tccgtcgagg
     3001 ccgcgcggat ggtggcccgg ctgccgtacg gcctggcgtc gctggatctg cacggccgga
     3061 tcggctacgt cagcccggcc gccgccaccc tgctcggcaa gaccccggac gaactgctcg
     3121 gcgccctgcc gtggatcgcg gtgccctggc tgaacgatcc gacgtacgag gaccgctacc
     3181 gggccgcgct gctgagccag cagccgacct cgttcgtggc gctgcggccg cccggcgact
     3241 ggctgtcctt ccggctgtat ccgaatctga ccgggctgag cgtgcgcatc ggccggaccc
     3301 acccgatggc cgatgtggcg ccggccgccg cgccggtgga ggcgggaccg tcccggctgg
     3361 tgacgatctc ccaggtgctg aacctggcgg gcgcgctcac cgaggcggtg ggggtgcggg
     3421 acgtggtgcg gctggtctgg gacgagctgg cgcccgcggt gggctgccgg gcgctgacga
     3481 tcgccgcgcc gcagggcggc cggctgcatc tgctggggca tcgggggtac gccgatccgc
     3541 gcacggtgga gcggtgggag gggctgccgc tgtccgagcg gaccccgggc atgcgggcgc
     3601 tgagcagcgg ggtgcccgcg ttcttcgagt cccgggagca gctggggcgg ctctacccgg
     3661 agcgggagga gagcccggac ggcttcgcgg cctgggcgta tctgccgctg atcgcctccg
     3721 ggcggccggt cggcacctgt gtgctggcgt acgccgagcc gcggctcttc cccgccgacg
     3781 aacgggccgt actgaccgcc ctgggcgggc tgatcgcaca ggccctggag cgcgcgatgc
     3841 tctacgacgc cgagcatcag ctggcgcatg ggctgcaaca ggcgctgctg ccgcactcgc
     3901 tggcgttgct gccgggggtg gaggcggcgg cccggtatct gccggccacc catggcatgg
     3961 agatcggcgg cgacttctac gacctggtcg cggcccggcc cctgacggcg gcggtgatcg
     4021 gggacgtgca ggggcacaac gtgacggcgg cgggcctgat ggggcagctg cgcaccgcgg
     4081 tgcgggcgta caccgcggtg gggcagggcc cgcacgaggt gatggccagc accaaccggc
     4141 tgctgatcga cctgggcgtg gagctgttcg ccagctgtct gtatctgcgc ctcgacccgg
     4201 cggccgggct cgccgtgatg gcacgcgcgg gacatccgcc gccgctgctg aggcggcccg
     4261 acgggcaggt gcgggtgctg gacctggccg ggggtccgct gctcggcatc gacgcgtcgg
     4321 cggcgtaccc gacgaccgag gtcgccctcg cccccggttc ggtcctcgtc ctctacaccg
     4381 acggcctggt ggaatccccc ggcgtggaca tcgaggacgc cctcacggaa ctgagcgcgc
     4441 gcctcgcgga gttgggcgac ctgccgctgg agacgctcgc ggacgaactg gtgcgccgga
     4501 gcgtgccggc gggggcacgc cgcgacgatg tggcactgct gctcctgcgg gcacgtggcg
     4561 actgagagcc cccacgctcg gagcgacacg ttcagcgacc ggtcgatgac gttcagtttc
     4621 tgacacgtac cggaatcccc gcttcagcga atctgcacat tgaatgctca accaagccac
     4681 cgcggtcagc gcttctgcac atccgggcgc ccccggcccg ccccgggcgg ccgccgtgcc
     4741 ggacgcgccg cccgaggcaa gcccgtggcc gcgacgatgc cgtgccgcat gtgaaaaagt
     4801 cgccgacaag ccgtgcccgc gcctgcacgg ttgcaccccg tcatggatca agttccctgg
     4861 tgagggccct gtttgagtgg aagcgcggac ggcgtgcgtg ctttgatcct tcgcaccgcg
     4921 gccctcctcc tgttgatcgc ctgtcgaccg gaggggaccg ttcccccctt gtgaatatcc
     4981 atatgaaggg aagttccatc atgaactcca ccccccaggt ccagaccgcc gagatcgccg
     5041 acgccgagct ggacgccgtc tccggtggtc tccaggtgaa cgccctcagc accgtgaccg
     5101 gcgccgtcaa cggcatcgcc ccggtctccg acctggccaa cacggccatc ggcacggtcg
     5161 agggtgtcac cggcctgaac gtggccccgg tcaccggcct ggtcgccggt ctctgaccga
     5221 gccctccttg cgaacccgtc ggtcccggag ccgtcccccg gctccggggc tctcgggcgt
     5281 cccgaaccac ccgcgactcc cccacaggtg agggaagttc cgtgcaggtc cgccaacagg
     5341 ccctcgccaa actccagtcg ccccaggagc tggacctccc ggtgcggctc gcccgcccgc
     5401 agggccggct cgcgctcggg gtcaccgtcg ccgtcatggc cgcggcctcc gtctgggcgg
     5461 tgaccggatc ggtcgcctcc acggtgagcg cgggcgccat cctcacccac gggcagggca
     5521 gttacgtcct ccagagtccc gtggcggggc aggtgaccgc cgtcctcgcc cggcagggcc
     5581 gacagctgcc cgcgaacgcc cccgtgatca aggtccgtac cccgcaaggg gatgcggtcg
     5641 tccgcacggt cgccgcgggc cggatcacca cgctcgccgc caccatcggg cagatcgtgc
     5701 agaccggcac cgatgtggcc gccgtcgaga aggtcgccca cgcgaacgac ccgctgtacg
     5761 cgaccgtgta cgtccccgcc gagaacgccg ccgccatccc cgcgggcgcc gccgtggacc
     5821 tcaccgtctc ctccgtaccg gcgcagcgct acggcgtgct gcgcggccgg gtgcgctcgg
     5881 tggaccgggc cgcgcagtcc gcgcagtcga tcgccgcgtt cctcggcgac agccagctcg
     5941 gccggcagtt caccaaggac ggccgtccgg tcgccgtgac cgtggagctg gacaagtccc
     6001 gcaccgccaa gagcggttac cggtggtcga ccgccgacgg gccgccgttc cggccggact
     6061 ccatgaccct cgcctccgcc tccgtccggc tggccgacca gcaccccgtc gattggctgc
     6121 tcccgtgacg accgctccgc aggagacccg cggccgcaga cgcgccgccc ccgcccggcg
     6181 accgtccccc acgtcccgta ccggcacggt ccgtacgccc accgtgctcc agatggaggc
     6241 cgtcgagtgc ggcgccgccg ccctcgcgat ggtcctcggc cactacggcc ggcacgtccc
     6301 gctggaggag ctgcgcatcg cctgcggtgt ctcccgcgac ggctcgcgcg ccagcaacct
     6361 cctgaaggcg gcgcgcagtt acggcctgac cgccaagggc atgcagatgg acctggccgc
     6421 cctcgccgag gtgcgcgccc cggccatcct gttctgggag ttcaaccact acgtcgtcta
     6481 cgacgggacg ggccgccgcc tcggccggcg cggcatccac atcaacgacc ccgccaaggg
     6541 ccgccgtttc gtgcccctgg aggagttcga cggcagcttc accggtgtcg tcctggtact
     6601 ggagcccggc gcggacttca cccgcggcgg ccgcagaccg ggcgtgctcg gcgcgctgcc
     6661 ggcccggctg cgcggcaccg cgggcaccct gcccgccgcg gtgctggcca gcctgctgct
     6721 ggtcgcggtg ggcgcggccg tacccgcgct gagccgcacc tatatcgaca tgttcctgat
     6781 cggcgggcag acctcgctgc tgggcgtgct gttcacctcg atggccgcct gtgtgctgct
     6841 caccctggta ctgacctggc tccagcaggc caatctgctg cacggccgga tcatctcctc
     6901 caccctgagc agcgcccgct tcctgcgcca tctgctgcgg ctgccggtga cgttcttcgc
     6961 ccagcgctcc cccgccgacc tggtgcagcg ccttcagtcc aacgaccagg tggcggagac
     7021 gctggcccgc gacctcgcgg cggccggcgt ggacgcgatc gtggtcgtgc tgtacgcggt
     7081 gctgctctac acctacgacc cccagctgac gttcctcggc atcggcgtgg ccttgctgaa
     7141 catcgtcgcc atgcggctgg tcgtacggct gcgcgcgacc cgcacggcca agctgcgcgc
     7201 ggacaccgcc cggttgacca acaccgctta taccgggctc cagttgatcg agacgatgaa
     7261 ggcgaccggc ggtgaggacg gctacttccg caagtgggcc gggcagcacg ccgccacgct
     7321 ggaggagcag cagcgcctcg gggtgccgag cgcctggctt ggggtggtcg ccccgacgct
     7381 ggccacgttc aacagcgcgc tgatcctgtg gatcggtggg ctgcgcgccg tcgaggggca
     7441 tatctcggtg ggtctgctgg tggccttcca ggcgctggtg acccgcttca ccgcgccgct
     7501 gacccggctg aacggggtgg cggggcgcat ccaggacttc gcggccgacg tggcccggct
     7561 gaaggacgtg gagaacttcc aggccgatcc gctctacgcg cggggcggcc ccggcgacga
     7621 gacacggcgg ctgcgcggcc atgtcgagct ggagaacgtg gcgttcggct acagcccgct
     7681 ggacaagccg ctgctgagcg ggttcgacct gaccgtgggg ccggggcagc aggtggcgct
     7741 ggtgggcggc tcgggcagcg gcaagtccac ggtgtccagg ctcatttcgg gcctctacgc
     7801 gccctgggac ggggtgatcc ggatcgacgg ccggcgcctg gaggacatcc cgcgcggcgc
     7861 gctcgccgcc tccgtctcct tcgtggacca ggaggtgttc ctcttcgagg gctcggtccg
     7921 cgacaacgtc gccctgtggg acccctcgat cccggacgag gcggtggtcg aggcgctgaa
     7981 ggacgcggcc ctgtacgagg tggtggcgcg ccggcccggc ggcatccacg gcagggtcga
     8041 ccaggacggc cgcaacttct ccggcgggca gcgccaacgc ctggagatcg cccgggcgtt
     8101 ggtgcgcggg ccgagcgtcc tggtgctgga cgaggtgacc agcgcgctgg acgcgcagac
     8161 cgagctggtg gtgatggaca acctgcggcg gcgcggctgc gcctgtgtgg tgatcgcgca
     8221 ccggctgagc acggtccgcg acagcgacga gatcgtcgtg ctccagcacg gcacggtggt
     8281 cgaacgcggg cggcacgagg agctggtggc gcgcggcggc gcgtacgcgg cgctggttcg
     8341 ggagcgttga tgacgtctgt tcaggaggag tacgagggcg acctggtgct cggcgccctg
     8401 ggcgcgctcg gcacccgggt ggactgcgcc gggttcaccc gcctcgatct ggcgggcccc
     8461 caggtgctgt ggctggtggc ggccggcgcc ctggacctgt tcgcggtgga cgccgaacag
     8521 cagggccact ggaaccatct gggccgcctg gaggcgggcg cgctgctgct cggcccggtc
     8581 gccggtcccc ggcacaccct ggtggcccgc ccggcgcggg actgcgtggt gcaccgggtg
     8641 aatctgcgtg agctgtacca gcagacgggc acccagacct ggtcgtacga cgagtacggg
     8701 cggccgcagt acgtgccgcc cgcgtccagc ccgctggagt acgccctcgc gctcggtgtc
     8761 ggccgcggtc tgtccgtcct cttccaggct ccgctggccg aggagcggcc cgaagtcccc
     8821 acggacgacg atgtgttctg gatgcaggtg ccgcccggca gcgtccagtg cggctccctg
     8881 tacggcgcgg aggccgccgc cgatctgctg atggacccgg cgctgtggca gtcgctggtc
     8941 gaccagcagt accggctgct gaccgcgctg gaccgctgga tcgagcagct ggagcgcagc
     9001 catgagaccc ggacggccgc cgggatcaag gcgggtgagg cggcgggcgc ccaggcggac
     9061 cgcaccctgc tggcctcgat cggccgccgc tcggggcgtc gtacgacggc cgccgacgcc
     9121 gatgccacgt acgcggcctg cgcgttggtc gccgaggccg ccgggatcag gctcgccgag
     9181 cccgcgcgga gcggcaccga gagcgagcgc ctcgatccgg tggagcgggt ggcgctggcc
     9241 tcccgggtgc gcacccgtgc ggtacggctc gaaggacgct ggtggcggga gaacgtgggc
     9301 ccgctggtgg ggcggcgggc gctgtccggg gcgccggtcg ccctgctgtg gcggcgcggc
     9361 ggctatgcgg ccgtccaccc cggcagcggc cgggagacac ccgtcggcag ggcgaacgcc
     9421 gaggagttcg agccgcgcgc ggtgatgttc taccggccgc tgcccgacaa ggcgctctca
     9481 ccgctcgggc tgctccggtt cacgctgggc ggcgcccgcg gcgatctgct cgggctgctg
     9541 ctcgcgggtc tggtgacggt ggcgatcggc gcgctggtgc ccatcgccac cggcaaggtg
     9601 ctcggcgagt acgtgccgag ggccgaggag ggcctgatcg tccaggtgtg cctggcggtg
     9661 ctggtgagcg gggtggtgtc ggcggcgttc accctgctgg agaacctgtc gatcctgcgc
     9721 cttgaggggc gcgtggaggc ggcgctgcaa ccggccgtct gggaccggct gttgcggctg
     9781 cccacccgct tcttctccga gcgctccacc ggtgaactgg ccagtgcggc catggggatc
     9841 agcgcgatgc gccggatgct ggcgggcgtc ggtccggtgg tcgcccagtc ggtgacggtc
     9901 ggcgcgatga acctcggtct gctgctgtgg tacagcgtgc cgatggcgct cgcggcgatc
     9961 ggcatgctgg tcgtgatcgc ggccgtgttc ctggggctcg ggctgtggca ggtgcgctgg
    10021 cagcggcgtc tggtggtgct cggcaaccag ctgaacaacc aggcgttcca gaccctgcgc
    10081 gggctgccca agctgcgggt cgcggccgcc gagaactacg cgtacgccgc ctgggcacgg
    10141 gagttcgcgc gcagccggga gctccagcag aaggccgggc ggatcaagaa cctcaccgcg
    10201 gtgctcggcg cggtct
//
