LOCUS       NZ_CP071875            26442 bp    DNA     circular CON 27-MAR-2024
DEFINITION  Paenibacillus polymyxa strain SF05 chromosome, complete genome.
ACCESSION   NZ_CP071875
VERSION     NZ_CP071875.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5459135)
  AUTHORS   Chen,B., Zhao,F. and Han,H.
  TITLE     The complete genome sequence of Paenibacillus polymyxa SF05, an
            antagonistic strain isolated from maize sheath
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5459135)
  AUTHORS   Chen,B., Zhao,F. and Han,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Institute of Maize and Featured Dryland
            Crops, Zhejiang Academy of Agricultural Sciences, Tangxi Village,
            Chengdong Sub-district, Dongyang, Jinhua, Zhejiang 322100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. v3.6.2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Nanopore; Illumina PE150
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028751565.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 02:05:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,074
            CDSs (total)                      :: 4,919
            Genes (coding)                    :: 4,764
            CDSs (with protein)               :: 4,764
            Genes (RNA)                       :: 155
            rRNAs                             :: 15, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 108
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 76 of 155
            Pseudo Genes (incomplete)         :: 112 of 155
            Pseudo Genes (internal stop)      :: 26 of 155
            Pseudo Genes (multiple problems)  :: 50 of 155
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:54:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5141679
            Orig. end                         :: 5168121
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071875.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26442
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="17"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26442
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26442
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16442](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16442)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(118..1131)
                     /locus_tag="J4I02_RS23915"
                     /old_locus_tag="J4I02_23620"
     CDS             complement(118..1131)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312501.1"
                     /locus_tag="J4I02_RS23915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23620"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_274483118.1"
                     /transl_table=11
                     /translation="MKKPTIEDVAQKAGVSKSTVSQFLNKRYKYMSDQTRDRIAEVIQE
                     LNYQPNGLARSLKQNRTFMVGVIVANIDYTLSIQSIRAIEEELQLFGIQVIICNADENP
                     DKESQYIEMLKARQVDGLIIFPTGKHADIYNQLIREKYPLVFLDRLVDGVNTRSLLLDN
                     EMAIKLAIQELVAHKHERIALITLPLGLNRITPRVERLSGYKKALEEHGLPFREEYMRS
                     VPREEIQQTLKELFQMPEPPTALLAGNDIVLAEVLKYVNARRIRIPVELSIIGIDDAEF
                     AHIYNPPITTITQPIADMGKQAAKTLLSSIEEGGESVPIIYRFVPDINRGESVKTL"
     misc_feature    1184..1198
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.86"
                     /tool="antismash"
     misc_feature    complement(1187..1203)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.7"
                     /tool="antismash"
     gene            complement(1387..2796)
                     /locus_tag="J4I02_RS23920"
                     /old_locus_tag="J4I02_23625"
     CDS             complement(1387..2796)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312502.1"
                     /locus_tag="J4I02_RS23920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23625"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_274483119.1"
                     /transl_table=11
                     /translation="MTTRALKKGSVLSEAKELNLFRLTWPIFLELFLFMLMGSVDTFMI
                     SSVSDNAVSGVGASNQIISIAILVLEVIGNGAAIVVAQYIGSKKLVEAAQVTGTAITLN
                     LMVGLLLSVIFLVFGTHMLQWLNVQGDILTYAESYMSIVGGAIFLQALINALAATIRTH
                     GFTKETMYVSVFMNVIHVVGNYVLIFGHWGMPALGVEGAAISTVGSRFICLLIFFWLMY
                     RVTEVRVEWKYYVQLSKKFISKILRIGVPSALESIMYQSCQLIFTLYVTYLGAEAMATR
                     QYANNISSYIYLFSMAVGMGTAIVVGRLVGARQKDTAYKRVLTSVKWALLVTVIIDAVV
                     IFFRVPLLGLFTENPEIIRLGAQVILLSILLETGRTTNIVIINSLRAAGDAKFPVFMGL
                     ISMVCMSLPLGYLLVFKLDMGLAGVWLAIAADEWTRAVIMYARWKSRLWEKHALVEHDT
                     PDQSATPVPAH"
     gene            3154..4161
                     /locus_tag="J4I02_RS23925"
                     /old_locus_tag="J4I02_23630"
     CDS             3154..4161
                     /EC_number="1.3.1.95"
                     /GO_function="GO:0016655 - oxidoreductase activity, acting
                     on NAD(P)H, quinone or similar compound as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (22-201). E-value: 3e-25. Score:
                     80.9. Matches aSDomain:
                     nrpspksdomains_J4I02_RS23925_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312503.1"
                     /locus_tag="J4I02_RS23925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23630"
                     /product="acryloyl-CoA reductase"
                     /protein_id="WP_274483120.1"
                     /sec_met_domain="ADH_N (E-value: 3.7e-05, bitscore: 21.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-13, bitscore:
                     49.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSFQALVVDQTKDGEVQAEVRSLEASSLPAGEVLIRVAYSSIN
                     YKDGLAARKDGNIVKSYPFVPGIDCSGTVVSSEDSRFSEGQAVLVTGYGLGVSQFGGFS
                     QYARVPADWVVPLPDGLTPREAMIFGTAGFTAALSLYRLEQNGVTPEQGKVLVTGATGG
                     VGGAAIALLNKRGYHVVASSGKADAHDYLKALGAAEIISREEVYDGAESIRPLGKQLWQ
                     AAVDPVGGKPLASLLSQIAYNGSVAVSGLTAGTKLPTTVLPFILRGVSLLGIDSVFCPY
                     DTRLAIWKRLGNEWKPEQLEQLVEREVGLADLPSALEDILAARSQGRTLVRLVD"
     aSDomain        3220..3756
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_J4I02_RS23925_PKS_ER.1"
                     /evalue="3.00E-25"
                     /label="J4I02_RS23925_PKS_ER.1"
                     /locus_tag="J4I02_RS23925"
                     /protein_end="201"
                     /protein_start="22"
                     /score="80.9"
                     /tool="antismash"
                     /translation="RSLEASSLPAGEVLIRVAYSSINYKDGLAARKDGNIVKSYPFVPG
                     IDCSGTVVSSEDSRFSEGQAVLVTGYGLGVSQFGGFSQYARVPADWVVPLPDGLTPREA
                     MIFGTAGFTAALSLYRLEQNGVTPEQGKVLVTGATGGVGGAAIALLNKRGYHVVASSGK
                     ADAHDYLKALGAAEII"
     CDS_motif       3613..3666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_J4I02_RS23925_0001"
                     /evalue="7.90E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="J4I02_RS23925"
                     /protein_end="171"
                     /protein_start="153"
                     /score="15.3"
                     /tool="antismash"
                     /translation="KVLVTGATGGVGGAAIAL"
     misc_feature    4239..4256
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            4397..4957
                     /locus_tag="J4I02_RS23930"
                     /old_locus_tag="J4I02_23635"
     CDS             4397..4957
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373621.1"
                     /locus_tag="J4I02_RS23930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23635"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_274483121.1"
                     /transl_table=11
                     /translation="MESNRELFDLYQRDVYRTCYYMVHNASDAEDLTQEVFITLFRSNR
                     EQIEQLKAWIMKITVNHCLNYLKRQKSLHLKVSANPYLFSGAEGKPVDRLVEERESAEE
                     WAVYMNRLPAKIRAVLTLRYMHDFTLAEISKLLEIPLGTVKSRTHKGLKLLEQILRDAG
                     VQIPEMEGENYEQRRKGIEAQVK"
     misc_feature    complement(4419..4432)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            4917..6602
                     /locus_tag="J4I02_RS23935"
                     /old_locus_tag="J4I02_23640"
     CDS             4917..6602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688920.1"
                     /locus_tag="J4I02_RS23935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23640"
                     /product="DUF4179 domain-containing protein"
                     /protein_id="WP_274483122.1"
                     /transl_table=11
                     /translation="MNNVEKALKRKLNDDSEMAYPDFDEMWNRMEQTGHTAPTLTDTFD
                     SFTPHRHRNWRKIAIAASLSALLVAVPVYAAIHYNWDNLLHGRSGIQTALNQDLGQTLE
                     QSVTRDGVKLTLHTAIVDENRTVILYSLEVGKRADNEFWNVKGVSLKSAAGESSAGEYN
                     FQQWDPTNQRYNGYFESDWTPQQETENVQLTIDHIELTSVQELDLPLDITSPQMQTFKL
                     DRNGLQDMKVQVFEQGKDKLMLSSAITFDSSIPKKWDNPQIIAYKGDEPVMSQPGGAFG
                     KPGDNGEYTAQQYFSKVDIPEGQTAFKLQYAQTEKSINEPIKFDLQLSKKKMESGTIKS
                     VLNIPLEKGNPNVLLEQMIVTPTQIRVTLRSKEKFAMLPYQKYFLSVNGTTLEGSRWSS
                     PDQEHDLNTIRFERPSNLVITKDSPITFTGKYKVTTHSDDKTPQRLTDISEQKQTLTTQ
                     VGGYPVKWTYYKQGSDLFVETESEDAHFGGINQTHMGLGKERIIGKPITANFAGDGNNK
                     AVDVYKNFKGKEASIYMFYYTTDDPEAETTVPLQPMTSNSEASK"
     gene            complement(6712..7536)
                     /locus_tag="J4I02_RS23940"
                     /old_locus_tag="J4I02_23645"
     CDS             complement(6712..7536)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426161.1"
                     /locus_tag="J4I02_RS23940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23645"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_023990874.1"
                     /transl_table=11
                     /translation="MKTSRRTNWPVLLLVALGTIFILFPLYMTVTIALKNPEQMAHSAF
                     AFPTELHWENFSRAVEMTNFFSAFQNSVMVTTSTVILTLLTNSMVAYAIARNMQRRFFK
                     GLYFYFVSAMFIPFPIIMLPIVKLASGLHMTNLLGLIMLHTVYGLAFNVFVYVGYIRSI
                     PVALEEAATVDGATTWGTFWRIIFPLMAPISATVGILTCLSTYNDFLLPLIIISDAEQY
                     TLPLVQYVFQGQFNTDFNLAFASYLMALLPMIIVYLIAQKWIINGVTQGSVK"
     gene            complement(7536..8402)
                     /locus_tag="J4I02_RS23945"
                     /old_locus_tag="J4I02_23650"
     CDS             complement(7536..8402)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373624.1"
                     /locus_tag="J4I02_RS23945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23650"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_274483123.1"
                     /transl_table=11
                     /translation="MNKRLTTFYWMTVPAVLLFFVFLTLPALQGFYYSLTNWNGFGHRY
                     HFVGFKNYINLFQDDNVGNAYWFTFKFAIVVTIATNILSLLIALGLNAKIRFRNFFRGI
                     YFLPNILSVLIVGYIFNYLFSNVFTIWGQNLGITSLSTNILGSEQLAWVGIVIVAVWQG
                     IAFNTILYLAGLQTIPTSLYEASNLDGAGKWREFWSITFPLIAPFFTINMVLAMKNSLM
                     VFDQIVALTNGGPGRATQSISHLIYTGGFRGGEFAYQSANSVIYFIVIAIISILQLRFL
                     QRREMDN"
     gene            complement(8419..9651)
                     /locus_tag="J4I02_RS23950"
                     /old_locus_tag="J4I02_23655"
     CDS             complement(8419..9651)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822710.1"
                     /locus_tag="J4I02_RS23950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23655"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_274483124.1"
                     /transl_table=11
                     /translation="MWCWVKKLSTLAVILLLAIIVSACNKGDASGKVKIEFFQNKPEAK
                     GSFDKLISQFNQEHPGIEVTQVNPPEAETVLLTRVVKNDVPDIVGLGATDTYSILAQSG
                     IFTDLANTELPRTIDPIYLKMLKDVTGVDPVYGIPYAANANGVMYNKTLFKEMGLQVPK
                     TWDELIATAQKIKAAGKVPFYFTYKDDWQTNLPFNALGPNLVGIDFFLQRRENQVTFQD
                     KYREVAEKQLELLKYGHSDNFGKNYADGNRAFANGQGLMYIQGSWAISEIRKANPKVEL
                     GFFPLPTGNDEKAVKLVSGIDTLLAVSESTPHKKEAEEFIAFLLKPENSKQYITEQTLF
                     SAVKGVTQDDPSVAELLPYFKSGRVVDFADHYIPKAVQLNSIVQAFLQNRDIDAYLAKL
                     DREWDKVANRR"
     misc_feature    9936..9949
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.83"
                     /tool="antismash"
     gene            complement(10001..11383)
                     /locus_tag="J4I02_RS23955"
                     /old_locus_tag="J4I02_23660"
     CDS             complement(10001..11383)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="J4I02_RS23955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23660"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_274483125.1"
                     /sec_met_domain="LANC_like (E-value: 6.2e-56, bitscore:
                     187.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTSYICDKWIPINLDMKDKVTVILQEIANRYKDPDQVRMYMKK
                     TPPIEADGMKMDRWSDESLGSGFTGICLLMGQLDRLYPEDGWDIVGHQYLERIRMIVEQ
                     KGVYDLSLYSGLSGILLAIYSLSRKGTRYQGMLDSLASWFEEAVLHNLVLCRKEWGRGQ
                     LQMSQYDAISGFTGIGRIAMLFSDRPTMHTIWNQTIELFQIMCSDRTWNGHPVPGWYIT
                     TENQFQKNEKKQYPQGNFNLGLSHGIAGPLAFLSLSALNGADSLPLVGDINRLSQFIHH
                     WLVQDTEGVIWPGRVSLEEWVDNRLQPESTQYYRDSWCYGVPGIARSIWLAGQALQNKD
                     WIETGLHAYLDIEKRLYRKGGLSSATLCHGIGGLLHLIQRMYSDTGHEQLGMMRDRLLE
                     EVLDMFDTNSAFGFYDHSLLDGRLTEVDEAGFLNGSAGVALVLASLIGNESPDWDAALL
                     IR"
     gene            complement(11380..12981)
                     /locus_tag="J4I02_RS23960"
                     /old_locus_tag="J4I02_23665"
     CDS             complement(11380..12981)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="J4I02_RS23960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23665"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_274483126.1"
                     /transl_table=11
                     /translation="MSQSYVEGVLESVLSKSLNIMIGEKSGYLGLADYENSQINDQLKR
                     ASQEASYRPYQLYTQMAGILSSLVTMLSSAVLLFLWKWWVVVILFVISLVSVYSIFKLN
                     KEQFEIYMNRTPLYRQSWYMTYLLTNDRAVKEVKIFNLGPYLLKRYENLLQRFFVEDRR
                     ILGKRVRITFLYSLLELSVLLWIVWMAIQETFVKKILIGNLYGYIQAIMLTQSQMQALI
                     QGIVQFSQNNLYMEQLFVFLQLPTSDPIRRQKEQALLDHPKSSTGFCIEQISIEGVSFT
                     YPGQSKASIQDMHLTMTKGQTIAIVGKNGSGKSTLMKILMQLYSDYSGVIKINDRPVQD
                     YDLQQVQDKIGVVFQDFMHYEMSARHNIGFGSLGLMEQDEELIHAAQCAAIDQIIAKLP
                     QGLDTQLGKWFEDGYQLSGGQWQRIAIARAFLRKADVYILDEPSSFLDPVAEQDLLVLF
                     LELMKDSIGIFITHRISSARLAHKIVVMDNGLIVEQGTHKELMLLNGLYAEMYNIQASS
                     FDEEASLIESGGRVLG"
     gene            complement(13263..16442)
                     /locus_tag="J4I02_RS23965"
                     /old_locus_tag="J4I02_23670"
     CDS             complement(13263..16442)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="J4I02_RS23965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23670"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274483127.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.6e-180,
                     bitscore: 598.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.9e-13,
                     bitscore: 48.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.6e-35, bitscore:
                     119.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEHLYKTLDFFMLRTPVLTMEEFGKCFLTNVGETEGIRQVAINR
                     LTELSRNPFIREALAASSPTLLESLVHISDQDNPRKQEQVIKSFMRYITRMATRPTPFG
                     LLSGVTYGQFGEQSQLILQEPDMYRKRARPDMEWLMKAVEMVTSSKEVVRQLRVQRNTL
                     IYRQGNRAKIPYTTRCGSIVGGEDQSVSVRATQVFDCVMEASSTLIPYQELVNHLHKTF
                     ERADIETIDRYVWQLFEQEFLISELIPPTTTTEPLDHIRSVLKLVTGIDELKENFNNIA
                     DNINKYNRLPIGQGEDSLEHLRRKMGKMFSAKSSLQIDLSLEDRGVVLPQCIRKDVECV
                     AELLTKLSSRENRPLDEFCMEFLEKYGPYREVPLLELLDEDTGMGAPAGYKHPLSNRTR
                     LQNMSPSQSRSHQEKLLFQWFVSCIHEGKHEVVLTDAMIDEMLKGQKSGKWLAAPSMEL
                     FFQLVAPDQQAVDRGEYTLLLAPNQGSDGAGKTFGRFLDLFDEPFTDMFSSIQSEEQRL
                     QPEKLLAEISYLPSSGRSANVVLTKQTRPYEIAIGTNHTLPKEQQIHVSDLAVGVRNDH
                     FYLKSISRNREVIARAGHMLNAELTPNIHRFLLEVSEDGYRHWSSMEWGFATHAPFTPR
                     LRYKHVILNPATWRMTWDAATSPSKDMIDSENLVYKFQKEWNLPRYVYMIELDNRILLD
                     MNHPLHVEQVCRDLQSKGKVTLIEHIGEVGETPVSRHSGRLAAEFVFPFIRKQAVATNH
                     FEEEVAATLDRKHEDTSRLSSEATCTYLPGGPWFYAKLYGMNSRQDEFIGGYWDEFVRK
                     HQEDGNILQGYFIRYADPDKHIRVRFKLQEFQEGNLFLPVFHQWTEMLLNEGMISRVVI
                     DTYEPEVERYGGKKLMMWAERMFSCDSEVTAKLVRLIRFNQTSLQKDVIAILSVINLLY
                     QFGYYEESAFQFLNRQFDLKDYLKDFRRERKFFLQWMGSDQEMTASTASSRESIENIFY
                     ARKEAVEQYNYILHEQEREGGATNTREDIIYSVIHMHLNRLIGIDRDRERKIMIMARHA
                     MNSLVQYRGNR"
     aSDomain        complement(15693..15974)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_J4I02_RS23965_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-15"
                     /identifier="RREFam001.1"
                     /label="J4I02_RS23965"
                     /locus_tag="J4I02_RS23965"
                     /protein_end="250"
                     /protein_start="156"
                     /score="48.5"
                     /tool="antismash"
                     /translation="RVQRNTLIYRQGNRAKIPYTTRCGSIVGGEDQSVSVRATQVFDCV
                     MEASSTLIPYQELVNHLHKTFERADIETIDRYVWQLFEQEFLISELIPP"
     gene            complement(16474..17241)
                     /locus_tag="J4I02_RS23970"
                     /old_locus_tag="J4I02_23675"
     CDS             complement(16474..17241)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312509.1"
                     /locus_tag="J4I02_RS23970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23675"
                     /product="ABC transporter permease"
                     /protein_id="WP_274483128.1"
                     /transl_table=11
                     /translation="MLGIWRSEMERIWNRRSTLLLYTIFLLMVIANIVSLKINGTMKFR
                     FGEGIATVNNLNLPWLMMSEISLFLILALLPILYVDQLSGDIHSGAYRLYVLRPYRRFQ
                     FWLGKLFALSVTTIVFTGTALLIGILAGWTIFPRSLTFFKYGSAEASTSLDAMSYTLVF
                     YLVLTLVCLAKLMLSSAVCLFISRPLFSFISILFISMFIYPLYKPLVMLIDPFQQIMLA
                     LRVDGSTRFWMCLIVIILICSTISFVRWQKKTI"
     gene            complement(17255..18049)
                     /locus_tag="J4I02_RS23975"
                     /old_locus_tag="J4I02_23680"
     CDS             complement(17255..18049)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312510.1"
                     /locus_tag="J4I02_RS23975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23680"
                     /product="ABC transporter permease"
                     /protein_id="WP_274483129.1"
                     /transl_table=11
                     /translation="MKTLIYSEFERLYSRKWFWLLILCTPVLAYSTASYFLYLKTSVEV
                     LSKVFVIVGLQENLFLICNIAVAALVATLYTEQFRGGQLRLIFMRRFTRGQIFWSKLLV
                     LQVSVLLLLLILGLSLWGVGVWRFPYSEGETRQYGELIMYVFQYYAKAFVSLMAIGCLY
                     SYIAMCSKSVTHAIGICTTYNLFSLLFDGLYLKLASLFSHIPYIHDLIVFLFIPYMQYR
                     GLKTSLSGNLSANGAIATVVILYLILFTWGAYRRFTKDDYLY"
     gene            complement(18046..18774)
                     /locus_tag="J4I02_RS23980"
                     /old_locus_tag="J4I02_23685"
     CDS             complement(18046..18774)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312511.1"
                     /locus_tag="J4I02_RS23980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23685"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_274483130.1"
                     /transl_table=11
                     /translation="MSDVLLKVEKVSKKMGKRTLLSDISFELEKGKIYGFIGPNGAGKT
                     TMMRIMTGLMHSTSGSVRIASYDVQADREKALSKVGAIIESPVFFDYMTGKQVLRNLSR
                     LHPNIKSSDREKHIEELLERVGLDLRGDDRVKTYSLGMKQRLGIAQSMLGNPELLLLDE
                     PSNGLDPMGMRELRDIILRLRNSENYAFFISSHLLDELQQMCDELIVIKEGTLVWKGPA
                     DQLIEEGQRLEDAFMELMGL"
     misc_feature    complement(18924..18936)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.78"
                     /tool="antismash"
     gene            complement(18952..19125)
                     /locus_tag="J4I02_RS23985"
                     /old_locus_tag="J4I02_23690"
     CDS             complement(18952..19125)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="J4I02_RS23985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23690"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_274483131.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.5e-07, bitscore:
                     28.8, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENLFDLDVQVNKSQGSVEPKIRSIWNCSSGCGGGNTSQTCVET
                     CSPCFSNIGTLC"
     CDS_motif       complement(19060..19125)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAENLFDLDVQVNKSQGSVEPK"
                     /locus_tag="J4I02_RS23985_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18952..19059)
                     /prepeptide="core"
                     /locus_tag="J4I02_RS23985_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="8.40"
                     /molecular_weight="3406.8"
                     /monoisotopic_mass="3404.5"
                     /core_sequence="IRSIWNCSSGCGGGNTSQTCVETCSPCFSNIGTLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAENLFDLDVQVNKSQGSVEPK"
                     /leader_location="[19059:19125](-)"
                     /alternative_weights="3424.8"
                     /alternative_weights="3442.8"
                     /alternative_weights="3460.9"
                     /alternative_weights="3478.9"
     misc_feature    complement(19239..19254)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.26"
                     /tool="antismash"
     misc_feature    complement(19372..19384)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     gene            19627..19944
                     /locus_tag="J4I02_RS23990"
                     /old_locus_tag="J4I02_23695"
     CDS             19627..19944
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024908.4"
                     /locus_tag="J4I02_RS23990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23695"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_274483132.1"
                     /transl_table=11
                     /translation="MKAIELRLARVPVREVMEQLGIRNKTQLETWMRWYRKGEVHRLEQ
                     PVGKQYSYRKGPEHSSELEKVKAENRFLKQQLDLLKKYKELEKRWNQKSPWPGSNPFET
                     K"
     gene            19911..20336
                     /locus_tag="J4I02_RS23995"
                     /old_locus_tag="J4I02_23700"
     CDS             19911..20336
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024673.4"
                     /locus_tag="J4I02_RS23995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23700"
                     /product="IS3 family transposase"
                     /protein_id="WP_274483133.1"
                     /transl_table=11
                     /translation="MAWIESIRDEVTVSEACTWLGIARATYYRWKAAVGTEYADKAVER
                     IRELCIRHKFRYGYRKITALLRAEQRMNHKRVQRMMQREGLQCRVRMKKRKATGQPAGC
                     LSSRKSAEAAIPCRGAPAKARYGHHLFTVWRKDVVLL"
     gene            complement(20333..20524)
                     /locus_tag="J4I02_RS24000"
                     /old_locus_tag="J4I02_23705"
     CDS             complement(20333..20524)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="J4I02_RS24000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23705"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_274483134.1"
                     /transl_table=11
                     /translation="MPNVVMEVQQITKVIGKRQVIHDSSFQLDKGKIYGFIGPNGVGKT
                     TLMRMMTGLMHPTSGHEC"
     gene            complement(20733..20846)
                     /locus_tag="J4I02_RS24005"
                     /old_locus_tag="J4I02_23710"
     CDS             complement(20733..20846)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="J4I02_RS24005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23710"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_337999820.1"
                     /transl_table=11
                     /translation="MNIERSLGKMENNIFDLDVQINKSKGSVEPQVTSLAW"
     misc_feature    complement(21555..21570)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            complement(21757..23832)
                     /gene="abc-f"
                     /locus_tag="J4I02_RS24010"
                     /old_locus_tag="J4I02_23715"
     CDS             complement(21757..23832)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="abc-f"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822707.1"
                     /locus_tag="J4I02_RS24010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23715"
                     /product="ABC-F type ribosomal protection protein"
                     /protein_id="WP_274483136.1"
                     /transl_table=11
                     /translation="MYIVNGQQLKKYHAANLILDGASFDIHTGEKVGLIGRNGSGKTTL
                     LRLIARLSRPDEGQLVIAKDTKIGYLPQIPAEFESFTVYETLAYAYRELKDCRNQMNTL
                     EREMSDPVVAADTGLLEKLLQSYASLQERFERNGGYEMDANMDQVADGLRIPKGMYTRS
                     FGSLSGGEKTKIALASQLIGRPDLLLLDEPTNHLDLKGLEWLEQFLQGYTGACVVVSHD
                     RYFLDRVAVKMIELEDGEAFTYYTNYSGYVKEKEERLLLQFEDYKEQQKRIKKMKEAIR
                     RLEEWGRNGDNEKFFKKAASIRKALERMELVKRPVLDPQGAEFHLKLEDRSGRRVLQFE
                     EIVKAYGESQILNGATGSLEFGEKVALLGDNGSGKTTLLKLLLGQESADAGTVQWGARV
                     EYGYLAQQEREWNSRATVLAYFKEEAGVEEGEARGLLAKYLFYGADVFKPVSMLSGGEW
                     SRLRLALLVMKKPNLLVLDEPTNHLDIDSREALEEALDTYTGTVLAISHDRYFVNKLAG
                     RVWELEAGKLTFYLGSFDEYRAKKRELENARLLSEGDAGGRSASASAASGGGSGTAAHS
                     SAASKGLETAARTGATSGANKGRARTESAGRLGASAAGSGAREAKAAKPSRTPAASSER
                     LERTIAAKEAELAAADAELELLGTSGDTIHMAELWDARERLQAELDMLLGEWVELE"
     gene            complement(23936..24079)
                     /locus_tag="J4I02_RS24015"
                     /old_locus_tag="J4I02_23720"
     CDS             complement(23936..24079)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007432937.1"
                     /locus_tag="J4I02_RS24015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23720"
                     /product="RAxF-45 family protein"
                     /protein_id="WP_165145821.1"
                     /transl_table=11
                     /translation="MNHEMLNNRISQLPIAMAGIVHAFPYNGRSLSNFNHMVVNIARRR
                     LP"
     gene            complement(24160..25338)
                     /locus_tag="J4I02_RS24020"
                     /old_locus_tag="J4I02_23725"
     CDS             complement(24160..25338)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688926.1"
                     /locus_tag="J4I02_RS24020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_23725"
                     /product="MFS transporter"
                     /protein_id="WP_274483137.1"
                     /transl_table=11
                     /translation="MNFKVVILTIATFTVGLVELIIGGVLPQIAQDLNVSVSTAGQLIM
                     IYALVYAIAGPTLLALTAKIERKRLYLWSMFIFILGSLLAFWSPNYAVLFVSRIITAAS
                     GSLIVTLSLTIAVKVVSKAYQARVLGVISMGVSSSIVLGIPAGVLIGNAFGWRVLFLII
                     ALLTVVAMIVINLFMERIPTEHVVPMRDQLKSLKNVKVISAHLVTTLTLAGHYTLYAYF
                     TPFLENMMGLNASWISVAYFVFGLAAVSGGFIGGSLADRFGTAKSILVVVGVFIAVMFL
                     LPFSIHSIYVFAPLLIIWGILSWALSPPMQSYLIENAPESGSIQQSFNFSALQVGIALG
                     SALGGVVIENSESVATNAWVGGAFVIVAFVCGVFSITRAGTSQTVRGHHSVS"
     regulatory      complement(25407..25506)
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(26261..26281)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.63"
                     /tool="antismash"
ORIGIN
        1 agaaatcggc cttaacttcc agtagcccgt attcgcattt gtgtgacctg agtagcatat
       61 gcaagctcag gtcgtacaaa ggaatacggg ctatttttaa tatagaacat gactcgtcta
      121 caacgtttta acggattctc cccgattgat atccggcaca aatcggtaaa taatcggaac
      181 cgattcgccg ccttcctcaa tgctggacag caacgtcttt gccgcttgct tccccatatc
      241 cgcaatcggt tgtgtaatgg tcgtaatcgg cggattgtaa atatgggcaa actccgcatc
      301 gtcaatcccg ataatagaca actccaccgg aatgcgtata cggcgggcat ttacatattt
      361 cagcacctct gctagcacaa tatcattccc ggccaacagc gcagtcggtg gctctggcat
      421 ttggaacaat tccttcagcg tctgctggat ttcttctctc ggcacactgc gcatatattc
      481 ttctcgaaat ggcaagccat gctcttccag cgcctttttg tatccgctga gccgctccac
      541 tcgtggagta atccgattca agccaagggg caaggtaatc agcgcaattc gttcatgctt
      601 atgggccaca agttcctgaa tcgccagctt aatcgccatt tcattgtcca gcagcaggct
      661 gcgcgtattt acaccgtcta ccagtcggtc caaaaacacc aacggatact tttcacgaat
      721 gagctggttg taaatgtctg catgcttgcc tgtcgggaag ataattaagc cgtccacttg
      781 acgggccttg agcatctcaa tatactggct ttccttgtcg gggttttcat cggcgttgca
      841 aatgatcacc tgaatgccaa aaagctgcaa ttcctcctca atcgcacgga tagactggat
      901 cgaaagggta tagtcaatgt tggctacaat gacccccacc ataaacgtcc gattttgctt
      961 caagctgcgg gccagcccgt taggctgata attcagctct tgaataacct cggcaatccg
     1021 gtctctggtc tggtcactca tatatttata tcgtttgttc agaaattgcg agacagtgct
     1081 tttagacact cctgccttct gggcaacatc ttcaatcgtt ggcttcttca tcggtacact
     1141 ccttgtcttt catgtactgc gttagtgcaa caaaagtata tctttttttt agtaaattta
     1201 ccatacttct atttatgaat gccattatga tagaagtcga acttcaaagt tgcctagtac
     1261 caccgtgtag aagtatggtt ctccagtagc aaaaagaggc agttcaagat gttctcttga
     1321 actgcctccg cgtacacaac tctatcgaaa agctaggttc cagctggccc taaatgctgc
     1381 tcgacatcaa tgtgccggaa cgggcgttgc agactgatct ggtgtatcgt gctcgaccag
     1441 cgcatgcttt tcccataacc ggcttttcca gcgggcatac atgatgacag cacgagtcca
     1501 ttcatcagca gcaatcgcca gccacacacc ggcgagcccc atgtccagct tgaacaccag
     1561 cagataacca agcggcaagc tcatgcaaac catggagatt agtcccataa agaccgggaa
     1621 cttcgcatct ccagcagcac gcaacgagtt aataatgacg atattcgtgg tccggccagt
     1681 ttctagcaga atgctaagta aaatgacctg cgctcccaaa cgaataattt cagggttttc
     1741 cgtgaacaaa ccaagcaagg gaacacggaa aaagatgacc accgcatcaa taatcacggt
     1801 cacgagtagc gcccatttta cactggtcag tacacgttta taggcagtat ccttctgtct
     1861 ggctcccacg agccttccta ccacgatagc cgtccccata ccgactgcca tactgaacaa
     1921 gtaaatatag cttgaaatat tatttgcata ttgacgtgtc gccatcgctt ctgcgcccag
     1981 ataagtcacg tacagtgtga agatgagctg acacgactga tacataatgg actccagcgc
     2041 ggatggtaca ccaatgcgca atattttaga gatgaacttt ttggacaatt ggacgtaata
     2101 tttccactcg acacgaacct cagtgacccg gtacatcagc cagaagaaga tcaggagaca
     2161 aataaagcgg ctaccgactg tagaaatagc agcaccctct actccaagcg caggcattcc
     2221 ccaatgccca aaaatcaaaa catagttgcc gaccacgtgg atcacgttca taaaaaccga
     2281 tacatacatt gtctctttgg taaaaccatg tgtacgaata gtcgccgcca gcgcgttaat
     2341 caatgcctga aggaaaatgg cccccccgac gatactcata taggattccg cgtacgtcag
     2401 aatatctccc tggacattca gccattgcaa catatgagta ccaaacacaa gaaaaattac
     2461 gctaagcaaa agacctacca tcaaattcaa cgtaatggcc gtacctgtaa cctgggccgc
     2521 ttcgactagt ttcttagaac cgatatattg agctacgacg atagcagcgc cgttgccgat
     2581 aacctccagt acaaggatag caattgaaat aatttgattg gacgcgccca cacccgacac
     2641 cgcattatca gatacagaac tgatcatgaa cgtgtcgacg ctccccatta gcataaacag
     2701 aaacaattca aggaaaatag gccatgttaa acggaacaaa ttcagttcct ttgcttcgga
     2761 caataccgaa ccttttttta gtgctctggt tgtcattcat tcacctttct tcatagattt
     2821 atttaacgat caaaaggtat gttagcacag taattctgaa aatacatccc gtttacgtaa
     2881 aatgatttgc aaaatacgta agaattcatt tatcactctc tttataattg attatcgaac
     2941 tttattgaaa caggatattg caagaatatt accagtagtc tggtcttttc gacgcaatga
     3001 tgagctaaag agtataatag aatacgagcc tgtgagcatt gccgctgaca ggttgtgcag
     3061 attgttgtat gcttctaagc ataatttgtg aattaaagat ggaatatata gggcattcat
     3121 agggttaaaa ggtaataaag gaggctttta cagatgactc aatcatttca ggctcttgtc
     3181 gtcgatcaga cgaaggacgg tgaagttcaa gcggaggtac gttctctgga agctagcagt
     3241 ttacctgctg gagaagtatt gattcgtgtc gcttattcca gtatcaatta taaagatggg
     3301 cttgctgccc gcaaggatgg caatattgtc aaatcctatc cattcgtacc aggcatagat
     3361 tgctcgggga ccgtcgtctc ttcggaggat agccgcttta gcgaaggaca agcggtgctc
     3421 gttaccggat acgggctggg tgtgtctcaa ttcggaggat tcagccaata tgcacgtgtg
     3481 cctgcggact gggtggttcc acttccagac ggactcacgc cgagagaggc gatgattttc
     3541 ggaacagccg gattcaccgc agccctatcg ttatatcggc tggaacaaaa cggcgttact
     3601 ccggagcagg gcaaggtact cgtcaccgga gcgacgggcg gcgtaggcgg ggcagctatt
     3661 gccctgctga acaagagagg ctaccatgtc gtagccagca gtggcaaggc cgatgctcac
     3721 gattacctca aggcgctcgg agcagccgag attatttccc gcgaggaagt ttacgacggt
     3781 gcggagagca tccgcccgct gggcaagcag ctttggcaag cggctgttga tcctgtaggc
     3841 ggaaagccgc tcgcttcgct gctcagccag atcgcctaca acggctccgt tgccgtgagc
     3901 ggcctgacgg caggcaccaa gctgcctacg acggtgctgc cgtttatttt gcgcggcgta
     3961 agtctgctgg gcatagactc tgtcttctgc ccatacgaca ctcgcctagc aatctggaag
     4021 cggctcggta acgaatggaa gccggaacag ctggagcagc ttgttgagcg cgaagtcgga
     4081 ttagctgacc tgccaagcgc gctcgaagac atccttgcag cccgctcgca aggaagaacg
     4141 ctagtacggc tggttgacta agcggagtag gtcgctagct atccattgac gtattttcac
     4201 gtgaagaagt gtcatcccat agggtctagc ttaggaacat gtaagaagct tgtaaatctg
     4261 aacttttgag atttacaggc ttcttttttt cgtgtggtac atttgaagcg gacgctttac
     4321 ttttcgcaac caaatgaacc ttttaaggaa ctcagttgtt atatagataa actgcacgag
     4381 aaaggagagc acatcattgg agagcaatcg agagttgttt gatttgtatc aacgagatgt
     4441 ataccgaacc tgctactaca tggtacataa tgcatcggat gcagaggatt taacgcagga
     4501 agtgtttatc accctgtttc gcagcaatcg tgaacagatc gaacaactaa aagcctggat
     4561 tatgaaaatt acagtcaatc attgtctgaa ttaccttaaa cgccagaaaa gcctgcattt
     4621 gaaggtatcg gctaatccct atctatttag cggggcggaa ggtaagcctg tagacaggct
     4681 ggtggaagaa cgcgaatcgg cagaggaatg ggccgtttat atgaatcgtc ttccagccaa
     4741 aatccgcgct gtgctgaccc tccgctatat gcatgatttc acgctggcgg aaatatcaaa
     4801 actgctggaa atcccgctgg gaaccgtcaa atcgaggact cacaaaggac taaagttatt
     4861 ggagcaaata ctgcgggatg caggggtaca aattcccgag atggaaggag agaactatga
     4921 acaacgtaga aaaggcattg aagcgcaagt taaatgatga ttcggaaatg gcctatcctg
     4981 acttcgatga gatgtggaac cgaatggaac agacagggca tactgcccct acgctaaccg
     5041 acactttcga ttcattcact ccgcaccgac atagaaattg gcgcaaaata gctatcgccg
     5101 cctctctgag tgcacttctc gttgccgttc ccgtctatgc cgccatccat tataattggg
     5161 acaatctgct gcacggaaga agcggcattc agacggcact aaatcaagac cttggacaga
     5221 ccttggagca atccgtaacc agagacggag tgaagctgac gctgcatacc gctattgtcg
     5281 atgagaaccg gaccgtgatt ctgtacagct tggaggtcgg aaaacgagca gacaacgagt
     5341 tttggaatgt caaaggcgta tcgctaaaaa gtgctgcggg ggaaagcagt gcaggggaat
     5401 ataacttcca gcaatgggac ccgacaaatc agcggtacaa cgggtacttt gaaagtgatt
     5461 ggacaccgca gcaagaaaca gagaacgtgc agttgaccat agatcatata gagctcacca
     5521 gcgttcagga actggatttg ccgctcgata tcacatcgcc tcagatgcag acgttcaagc
     5581 tggatcgtaa cggcttacaa gatatgaagg tacaggtatt cgaacaaggg aaagataaac
     5641 tgatgctatc ctcagcgatt accttcgatt cgtccatacc aaagaaatgg gacaatccac
     5701 aaattattgc ctacaaaggc gacgagcctg tgatgtcgca gcctggaggg gcttttggca
     5761 aacccggtga taacggggag tatacagcac agcaatattt ttccaaagtg gatataccgg
     5821 aaggacagac tgctttcaaa ctgcaatatg cgcaaaccga gaaaagtata aatgaaccca
     5881 taaaatttga cctgcagcta agcaagaaga agatggaaag cgggacgatt aaaagtgtgc
     5941 tgaatatccc actggagaaa ggcaatccaa atgttttgct agaacaaatg attgtcacac
     6001 ctacgcaaat ccgtgtcacg ctcagaagca aggagaaatt cgccatgtta ccttatcaaa
     6061 agtactttct ttctgtgaac ggcacaacgt tagagggtag tcgttggtca tcacctgatc
     6121 aggaacacga tctgaacaca atccgttttg aaaggccgtc caatcttgtg attaccaagg
     6181 acagtcctat tacttttaca ggcaaataca aggttacgac ccattcagat gacaaaacgc
     6241 ctcagcgttt aactgatatt tctgagcaaa agcagacact aacgacgcaa gtcggtggct
     6301 atcctgtgaa gtggacctac tataaacagg gatcagactt attcgtagaa accgaaagcg
     6361 aggacgctca ctttggaggg attaaccaga cacatatggg cctgggtaaa gaacggatta
     6421 tcggcaagcc gatcacagcc aatttcgcag gagatggcaa taacaaggca gtggatgtct
     6481 acaagaactt caaagggaag gaagcttcta tctatatgtt ctactataca acggacgacc
     6541 cggaagcaga gacaaccgta cccttacagc ctatgacaag caacagcgaa gcatccaaat
     6601 agcaatgcta taaaaagagg gtcctctata cctgtgtgaa ccgtggtata gggaacccct
     6661 ttttattttc ctaggaaggc acagtctgcc tgaagctgtt gtatccccac cttacttcac
     6721 agaaccttgc gtaacgccat tgataatcca tttttgtgca atcaaataga caataatcat
     6781 cggcagcaag gccattagat acgaggcaaa ggccaaatta aagtcggtat tgaactgccc
     6841 ctggaacaca tactgaacga gcggcagtgt atactgctcc gcatcgctga taataatgag
     6901 cggcagcagg aagtcgttat aggtggacag acaagtgaga attcccaccg tagcactaat
     6961 cggcgccatc agcgggaata taatacgcca aaaagtaccc catgtcgtcg caccatctac
     7021 cgtggctgcc tcttccaatg ccaccggaat ggagcgaata taaccaacat atacgaagac
     7081 attaaacgcc aaaccataca ccgtatgcag cataatgaga cccaacaaat tagtcatatg
     7141 aaggcccgag gccagtttta caatcggcag catgatgatc gggaacggta taaacatggc
     7201 gctcacaaaa taaaaatata atcccttaaa aaatcgtcgt tgcatattac gggcaatcgc
     7261 ataagcgacc atcgaattgg ttagcaaagt gagtatgacc gtcgatgtcg tgaccatcac
     7321 actgttttga aaagcgctga agaagttggt catttccact gcacgactaa aattctccca
     7381 atgcagctcg gttggaaagg caaaggcgga atgcgccatc tgctcgggat ttttaagtgc
     7441 gatcgtcacc gtcatataga ggggaaacag gataaatatt gtccccaacg ctaccagaag
     7501 cagcacaggc cagttggtac gtctgcttgt tttcatcagt tatccatctc ccttctctgg
     7561 aggaatcgca gctgtaagat ggaaatgatc gcgatcacaa taaagtaaat aacagagtta
     7621 gccgactgat aagcaaattc tccacctcta aatcccccgg tgtatatcag gtgggaaatc
     7681 gactgagtgg cccgtcccgg cccaccattc gtcaaagcca cgatctgatc gaacaccatc
     7741 agggaatttt tcatcgccaa taccatatta atcgtaaaaa acggtgcaat taacggaaag
     7801 gtaatgctcc agaattcgcg ccatttaccc gcaccgtcca ggttggacgc ctcatacaga
     7861 cttgtcggaa tggtttgcaa cccagccaga tagagaatcg tattaaaggc aatcccctgc
     7921 catacagcta cgatgacaat ccccacccaa gccagttgtt cactgcccaa aatgttcgtt
     7981 gacaatgagg taatacctaa attttgtccc caaatcgtaa acacgttcga gaacaagtaa
     8041 ttgaatatgt aacccacgat caacacgctc aaaatattag gcagaaaata aataccccgg
     8101 aaaaagttac gaaaccgtat tttagcattc agccctagcg caatcagcaa actaaggata
     8161 ttagtcgcaa tggtaaccac aatcgcaaat ttgaaagtaa accagtatgc gttccccaca
     8221 ttgtcgtcct gaaacaaatt aatatagttc ttaaacccga caaagtgata ccgatgacca
     8281 aagccattcc agttcgtaag cgaataataa aagccctgca aggcaggcaa ggtcaaaaat
     8341 acaaaaaaca atagcaccgc cggcaccgtc atccagtaaa aagtcgttag tcgcttattc
     8401 atgtctcctc ctcctctcct atcggcggtt agctacctta tcccattcac ggtcgagctt
     8461 ggccagataa gcgtcgatgt ctctgttttg caggaaggcc tgcacaatcg aattcaattg
     8521 aaccgctttg ggaatatagt gatcggcaaa atcaacgact cggcccgatt taaaatacgg
     8581 caacagctcc gccacacttg gatcatcctg cgtaactccc ttcaccgccg aaaacagcgt
     8641 ttgctctgta atgtactgct tgctgttctc cggcttcaat aagaaggcaa tgaactcctc
     8701 ggcttccttt ttatgcggag tgctctccga tacggctaat agcgtatcta taccggacac
     8761 cagcttgacc gccttttcgt cattccctgt cggtaatggg aaaaacccaa gctccacttt
     8821 cgggttggct ttgcgaattt cagatatggc ccacgagccc tgaatataca tcaatccctg
     8881 cccgttagcg aaggcacggt taccgtcggc atagtttttg ccaaaattat cactatgtcc
     8941 gtatttcagc agctccagct gcttttccgc aacctcgcgg tacttgtcct gaaaagtgac
     9001 ctgattttca cgccgttgca ggaaaaaatc aatacccacg agattcggac ccagtgcatt
     9061 aaaagggagg ttcgtttgcc aatcatcttt atatgtaaaa tagaacggga cttttccagc
     9121 agccttgatc ttttgcgccg ttgcaatcag ctcatcccac gttttgggca cctgtaatcc
     9181 catttcctta aaaagtgttt tgttatacat cacaccattc gcattcgcag cataaggaat
     9241 tccatacacg ggatcgaccc cggttacatc cttaagcatt ttgaggtaaa tcggatcaat
     9301 cgtacgtggc aattctgtat tcgccagatc cgtaaaaata ccgctctgcg ccaaaatgga
     9361 gtaggtatcg gtggccccaa gccccacaat gtcaggtaca tcgtttttga ccacccgggt
     9421 caataacacc gtctcagcct ctggcgggtt gacctgcgtc acttcaatac cgggatgttc
     9481 ctgattgaat tgagagatta gcttatcgaa tgaacccttg gcctccggct tgttttgaaa
     9541 aaactcaatt ttcaccttac ccgaagcatc acccttgttg catgcgctta caatgatcgc
     9601 tagtagcaga atcaccgcta gtgtagacag ctttttgacc caacaccaca tgctcatacc
     9661 tccttttccc ctatgtcaat ctatgcggga ctagacaatt aatacccgtc ccttatggaa
     9721 aagaaacgat acaccgtgtt tggcggttat atagtaaaag ggtactcatc ttcgctgttg
     9781 tttttctgtt ttgttcaggt attgggttat tgaatgggag tacaacaata ctgccttggg
     9841 attccatgta agtggaaccc agcttgaagg atgctaatga aaataccttg agtctcagga
     9901 ggaactagta tgttaaaaaa gatccaaccg gccttcaaac ggtcgattgg atcttttctt
     9961 acttttatta tgttcaggtt agggaataac atgacatatc ttagcgaatt agaagagcag
    10021 cgtcccaatc cggactttca tttcctatca atgaagccaa caccaaggca actccagcac
    10081 tcccattcag aaagccagcc tcatctactt ctgttagcct cccatccaat aggctatgat
    10141 cataaaagcc aaacgccgaa ttagtatcga acatatccag tacttcttct agtagcctgt
    10201 ctcgcatcat acctaactgc tcatggcccg tatctgaata catacgctgg atcagatgca
    10261 acaatccccc aataccatga cacaatgtcg cagaagatag tcctccttta cgatagagcc
    10321 ttttttctat atccaagtat gcatgtagtc ccgtttcgat ccaatcttta ttttgaagag
    10381 cttgtcccgc cagccagatc gaacgtgcaa tgcctggtac gccataacac caggaatcac
    10441 gataatactg cgtgctttca ggctgcagac ggttatccac ccattcctca agggaaacac
    10501 gcccaggcca aatcacgccc tcagtatcct gaacaagcca atgatgtata aattgtgaca
    10561 gtctgttaat atcgcccact aaagggaggg agtcggctcc attaagagca gacaggctca
    10621 gaaaagctaa tggacccgcg ataccatgcg aaagccctaa attaaaattc ccctgcggat
    10681 attgtttctt ttcattcttt tgaaattgat tctccgtggt aatataccat ccaggtacag
    10741 gatgtccatt ccaagtacgg tcgctgcaca ttatctgaaa caattcaatc gtctggttcc
    10801 atatggtatg catagtcggt ctatcggaaa ataacatggc gatgcgtccg atccctgtaa
    10861 agcctgatat ggcgtcatac tggctcattt gtaattgtcc tcttccccat tccttccgac
    10921 ataggaccaa gttatgtaga acagcctctt cgaaccagga ggcaagggaa tcaagcattc
    10981 cttgataacg tgtgcccttc ctggataaag agtaaatagc cagtaaaata cctgataatc
    11041 cactatacaa ggatagatca taaacaccct tttgttccac gatcatacga attcgctcta
    11101 aatattggtg tcctacaata tcccaaccat cctcagggta tagtcgatcc aactgaccca
    11161 ttaacaaaca gatgcccgtg aacccacttc ccaaactttc atctgaccaa cggtccatct
    11221 tcatcccatc agcctctatc gggggcgttt ttttcatata catacgcact tgatcggggt
    11281 ctttgtaacg attggcaatc tcttgtaaga ttacagttac tttatccttc atatccaaat
    11341 taatgggtat ccatttatca caaatatatg aagtcgtcgt catcctagca ccctccctcc
    11401 gctttcaatt aaggaagctt cttcatcgaa tgagctggcc tgaatgttgt acatttctgc
    11461 gtatagccca ttgagtaaca tcagctcctt atgtgttccc tgctccacaa ttaaaccatt
    11521 gtccattacc acaattttat gtgccagacg tgctgatgaa atccgatgag taataaaaat
    11581 accaatgcta tccttcatca actccaaaaa taataccaac aaatcctgtt ctgccacagg
    11641 atccaagaag gaacttggct catccaaaat atacacatct gctttacgca ggaaagcccg
    11701 tgcgattgct attcgctgcc attggcctcc tgagagttgg tagccatcct caaaccattt
    11761 accaagctgt gtgtccaaac cttgtggaag tttggctata atctggtcta tagctgcgca
    11821 ctgggctgca tggatgagct cctcatcctg ctccataagc cctaatgatc caaacccaat
    11881 gttatgacgt gctgacattt cataatgcat gaaatcttga aacacgactc caattttgtc
    11941 ttgaacctgc tgcagatcat aatcctgaac gggacggtcg ttaattttaa tgacgccact
    12001 ataatcagaa taaagctgca tcaggatctt cataagcgtc gattttcctg atccattttt
    12061 ccctacaatg gctatcgttt gtcctttagt cattgttaaa tgcatgtcct gaatagaagc
    12121 cttcgattga cccgggtacg taaaggaaac cccttcaatt gaaatttgtt caatgcaaaa
    12181 tccggtgctg ctctttgggt gatccagaag tgcctgttcc ttttgacgcc gaatggggtc
    12241 cgatgtgggc aactgtagaa atacaaataa ctgctccata tacaaattat tttgtgaaaa
    12301 ttgaacaata ccttggatta gtgcctgcat ttgactttgg gttagcataa tcgcttgaat
    12361 ataaccatat aagttcccta ttaatatttt tttcacaaag gtttcctgga ttgccatcca
    12421 tactatccat aacagaacag aaagttcaag caaactgtac aggaaagtaa ttctaactct
    12481 tttgcccaat atacgcctgt cttctacaaa aaatctttgc agtaaattct catatctttt
    12541 tagtaaataa ggacccaaat taaaaatctt cacttctttg accgcacgat catttgtaag
    12601 caaataggtc atataccatg actgtcgata taacggggta cgattcatat agatttcaaa
    12661 ctgttctttg tttaacttaa aaatcgagta aaccgacacc agtgaaatca caaatagaat
    12721 aaccacaacc caccatttcc ataagaaaag taaaactgcc gaagacagca tggtaactag
    12781 actagataaa ataccagcca tttgtgtata taattggtaa ggtcgatagg aagcttcttg
    12841 ggaagcccgc tttagctggt cgttgatttg agaattttca taatccgcca gtcccaagta
    12901 gcctgatttt tctccaatca tgatatttaa tgacttggac agcacagatt caaggacgcc
    12961 ctctacataa ctctgactca tcgtaactag actttttaaa acgtgaataa atataaagag
    13021 accaaattgt agcataatta tagagatatc atgaggacta gaagaaacaa tactattaag
    13081 taaattttgc atgataacca aagtaagtac gggcatcaca ccttgaatga tatgcaaaaa
    13141 aatgctagaa agcatataga ccttattcat gttaaatact aaggcaaaaa gcttaagccc
    13201 ttgacgtaca gacttccata tggaagaagt cctccgatct gtactttttt gtacgctact
    13261 cattagcgat tcccccgata ttgaaccagg ctgttcatag catgtctggc catgatcatt
    13321 attttgcgct cccgatccct gtcaattcca attaatcggt tcaaatgcat atggatcaca
    13381 ctgtatataa tatcctctct tgtattggta gcccccccct cccgttcctg ctcatggagt
    13441 atataattat attgctctac tgcttctttt cttgcataaa aaatattttc tatggattcg
    13501 cgactggatg cagtcgaagc tgtcatttcc tgatccgatc ccatccattg taaaaagaac
    13561 ttccgttccc tgcgaaagtc tttcaaatag tctttgaggt caaattgacg atttaagaat
    13621 tgaaacgcac tttcctcata gtaaccaaac tggtagagaa gattgatcac acttaaaata
    13681 gctataacgt ccttctgtaa agaagtctgg ttgaatctaa tgagacgtac caatttggct
    13741 gtcacttcac tgtcacagga aaacattcgt tctgcccaca tcatgagctt ctttccaccg
    13801 taacgctcta cttctggctc ataggtatcg attacaactc tggatatcat gccttcattt
    13861 aaaagcatct ctgtccattg atgaaacacg ggaagaaaca agtttccctc ctgaaactcc
    13921 tgtagcttaa accggacacg aatatgttta tctggatcag cgtatcggat aaagtacccc
    13981 tgaaggatgt taccgtcctc ttgatgcttc cgcacaaatt catcccaata accaccaata
    14041 aactcatctt ggcgactgtt cataccatat aacttggcat agaaccaagg accaccagga
    14101 agataagtgc aggttgcctc tgaggaaaga cgacttgtat cctcatgctt tctatctagt
    14161 gtggcagcaa cttcctcctc aaaatggttc gttgctacag cctgtttacg tataaatgga
    14221 aatacaaatt cagccgccaa gcgtccactg tgacgagaga ctggcgtttc accgacttca
    14281 cctatgtgtt cgattaaagt aacttttcct ttggattgaa gatctctaca aacctgttca
    14341 acatgcaaag gatgattcat atccaacagg attcgattat ctaattcaat catatataca
    14401 taacgtggta gattccattc tttttggaat ttatacacta aattttccga atcaatcata
    14461 tccttggatg ggctagttgc cgcatcccat gtcattctcc atgtagccgg attgagaatg
    14521 acatgcttat atcttagacg tggggtaaaa ggagcatggg tggcgaatcc ccactccata
    14581 gatgaccaat ggcgataacc atcctcactg acctccaaaa gaaaacgatg tatgttagga
    14641 gtcaattcag cattgagcat atgtccagcc ctagcaatga cctcacgatt gcgacttatc
    14701 gacttcaaat aaaaatgatc attacgtacc ccaacagcaa ggtccgaaac atgtatctgt
    14761 tgttcctttg gcagggtatg attggttcct attgcgattt cataggggcg agtctgcttc
    14821 gttaatacta catttgccga tcttcccgaa ctgggtaaat acgatatttc ggctaacagc
    14881 ttttcaggct gtaaccgttg ctcttccgat tgaatgctgg agaacatatc agtaaaaggc
    14941 tcgtcaaaca aatccagaaa tctcccgaac gtctttcccg ccccgtctga cccctgatta
    15001 ggtgccagaa gtaaagtata ctcgccacga tctacagcct gctgatcagg ggcgaccaac
    15061 tgaaaaaaca attccataga aggtgctgcc aaccatttgc ctgatttctg cccttttaac
    15121 atttcgtcta tcatggcatc tgtaagtacc acttcatgtt ttccttcatg gatgcaagat
    15181 acgaaccatt gaaataaaag cttctcctga tgtgatctcg actgggacgg tgacatgttt
    15241 tgaagccgtg ttcggttact caatggatgt ttgtagcctg ccggagcacc catccctgta
    15301 tcctcatcaa gaagctccag caaaggaacc tcccgatatg gaccatactt ttccaaaaat
    15361 tccatacaaa attcatccaa aggtctattc tctcgcgacg aaagcttagt tagtaattcg
    15421 gcaacacatt caacatcctt acggatacat tggggaagaa caactcctcg atcctccagg
    15481 gaaaggtcga tttgcaagct tgattttgca ctgaacattt tgcccatctt tcgtcttaaa
    15541 tgctccaacg aatcttcccc ttggcctata gggagacgat tatatttatt aatattatcc
    15601 gcgatgttat taaaattctc ttttaactca tcaatacccg ttactaattt caagacggat
    15661 cgtatatgat ccagaggttc ggtagtagtg gtaggaggaa taagctcaga tatcaaaaac
    15721 tcttgctcaa atagctgcca tacataacgg tcaattgtct cgatatcagc tctttcaaat
    15781 gtcttatgta gatggttgac cagttcctga taaggtatga gggtcgaact tgcttccatc
    15841 acacaatcaa atacctgagt cgcacgaacg gacacactct gatcttctcc accgactata
    15901 ctgccgcatc ttgtcgtgta gggaatttta gcccggttac cctgacgata aattaatgta
    15961 ttacgctgaa cccgcagctg gcggacaacc tccttactgc ttgtgaccat ttcaacggct
    16021 ttcattagcc attccatgtc cggtcttgca cgctttcgat acatatctgg ctcttgtaaa
    16081 atgagctgag actgctctcc aaattgtccg taagtgactc cagataacaa tccgaacggc
    16141 gtaggtcgtg tagccattct agtgatataa cgcataaagg atttgataac ttgttcctgt
    16201 ttgcgcggat tgtcctgatc gctgatatgt actaaagatt caagcagagt agggctggag
    16261 gcagctaacg cttcacgaat aaatggatta cgagataatt cagtaagacg atttattgca
    16321 acttgtctga ttccttcagt ctctccgaca ttggttagaa agcattttcc gaactcttcc
    16381 atagttagca caggagtacg aagcataaaa aaatccaggg ttttataaag atgctcttcc
    16441 attcccatta aacctccgtt ctaagccaaa cgtttaaatt gttttctttt gccaacgaac
    16501 aaagctaata gtcgaacaaa tcaatataat cacgattaga cacatccaga atctggtgga
    16561 accatccact cttaaagcaa gcataatttg ctggaaagga tctattaaca tcacaagtgg
    16621 cttgtaaagt gggtagataa acatagatat aaataaaata gaaataaacg agaataaagg
    16681 tctggatatg aacaaacaca ctgcactact tagcatgagc tttgccaggc aaaccaacgt
    16741 taataccaaa taaaacacaa gtgtatatga catagcatct aatgaggtgg aagcctctgc
    16801 tgagccgtat ttaaaaaagg ttaagctacg gggaaaaata gtccaaccag ccagtatgcc
    16861 tatgagcaag gctgtacccg taaaaacgat cgtcgtgacc gataatgcga acagttttcc
    16921 aagccaaaat tgaaagcgac ggtatggacg cagtacatat aaacgatacg ccccggagtg
    16981 aatatccccg cttaactgat ccacatacaa aataggcaac aatgccagga tcagaaatag
    17041 ggaaatttca ctcatcataa gccacggcaa gttcagatta ttaacagtgg caatcccttc
    17101 gccaaagcgg aatttcattg ttccattaat tttaagactg acaatattcg caataaccat
    17161 caatagaaaa attgtatata ataaaagagt agatcttcga ttccatattc gttccatttc
    17221 acttcgccaa attcctagca taagaaaaat cctcctaata caaataatca tccttggtaa
    17281 aacgacgata tgctccccat gtaaaaagga ttagatataa aataacaacg gtggcaatcg
    17341 ccccatttgc agacaggttt ccggataagg atgtcttcaa tcctctatac tgcatataag
    17401 gaataaataa aaagactata agatcatgta tgtagggaat atgagaaaat agagatgcta
    17461 atttaaggta taagccatcg aacagcaagg agaacagatt ataggtcgta caaataccaa
    17521 ttgcatgggt tacactcttg ctacacatgg caatatagga atacagacag ccaatagcca
    17581 taagtgagac aaaagccttt gcataatatt gaaatacata cattataagc tctccatatt
    17641 gccttgtttc gccttcagaa tagggaaatc gccatactcc gacaccccaa agagacaggc
    17701 ccaatataag taagagtaat agaacagaga cctgtaaaac caatagcttg ctccagaaaa
    17761 tctgtccccg agtaaaacgc cgcatgaaga ttagacgcaa ctgtccaccc cgaaattgct
    17821 ccgtatatag agtcgctact aatgcagcta cagcaatatt gcatattaaa aacaaatttt
    17881 cttgcaggcc tacaatgaca aagactttgg acaacacttc taccgaagtc ttgagataca
    17941 aaaaatagct ggctgtggaa taagcgagta caggggtaca taaaatcaga agccagaacc
    18001 attttctgct atacaatctc tcgaactcac tgtaaatgag tgtcttcata atcccattag
    18061 ctccatgaaa gcatcctcca gccgttgacc ttcctcaatc aattgatctg cgggtccctt
    18121 ccaaactagc gttccttctt taatcacaat taattcgtca cacatttgct gcaactcatc
    18181 cagcagatgg ctggagataa aaaatgcata attttctgaa tttcgcaaac gaaggataat
    18241 atctctcaac tccctcattc ccataggatc gagaccattg gaaggctcat cgagcagcag
    18301 tagctccggg ttacccagca tagattgggc aatgcccaag cgttgcttca tgcccaaaga
    18361 ataagttttc accctgtcgt ctccacgcaa atccaggcct actctttcta acaactcctc
    18421 tatatgcttt tcccgatcgg aagatttaat attcggatgc aaccgagaca aattacgcag
    18481 cacctgttta cccgtcatat aatcaaaaaa gaccggggac tcaatgatag cgcctacttt
    18541 ggagagcgcc ttttcccgat ccgcctgtac gtcatatgaa gctatcctta cagagccact
    18601 ggttgaatgc attaatcccg tcatgatccg catcattgtt gttttcccgg ctccattcgg
    18661 tccaatgaaa ccatatattt tccccttttc aagctcgaag gaaatgtcac ttaataaagt
    18721 ccgtttcccc atttttttgg atactttttc aactttcaat aagacatccg acattacact
    18781 ttccctccat tactaaatcc aaatataagg atgcctctga tattcacaag caggaaacca
    18841 aaggttttct caaagaagaa gaagaaggga cttcaaggtc cctcctcctt tgctaaatta
    18901 aatagttatc caatataaag gttttgcaag ttgcaaaaca actaaaattt attaacaaag
    18961 tgttcctata ttactgaagc aaggtgaaca tgtctcaaca caagtttggg atgtattacc
    19021 gccaccacag ccgctagagc aattccaaat acttctaatt ttaggctcta cagaaccttg
    19081 agatttgttt acttgaacgt ccagatcaaa taagttttca gccattgcat tccccccttt
    19141 cattcagata taccatcagc cttcagcgag gttcatgttt atcccgccaa agccttcctt
    19201 ctcgcaatag aagagaagga ttttatatga acaacacccc gaccagatcg tcacctactc
    19261 gaaatattgc catatatcac gtagacaacc gtatgtatga tctttgttga taacaaacac
    19321 ttcatctaac aataatttat atcttcctta caaataaaag aatatcacat gttgcaaaat
    19381 gtaaatctat tactttatat gtaaacatac ataacaaaaa atcattaata ccaatttatt
    19441 ttaatatatg gttattctat ttccactctc tcattctctt taccatacaa aaaaggggac
    19501 tgatcccata acgtgagaca catcaaaaca ccttcaagag aatcaagcca tgtcgtaaga
    19561 tatggagata accttggagg tgttcttacg ttggcaacga gagtgagtta tcccttagaa
    19621 ataaagatga aagcgattga attgagattg gcaagagttc cggtaagaga ggttatggag
    19681 caactgggaa tacggaataa gacacagcta gaaacatgga tgaggtggta tcgaaaaggc
    19741 gaagtgcatc gtctggagca gcctgtaggt aaacaataca gctacagaaa aggtccggaa
    19801 cactcttcgg agcttgaaaa agtaaaggcg gagaatcgat tcctgaagca gcaattggac
    19861 ctgctaaaaa agtacaagga actggaaaag aggtggaacc agaagtcgcc gtggcctgga
    19921 tcgaatccat tcgagacgaa gtgacggtgt ctgaggcttg tacatggctc ggaatcgcaa
    19981 gagcgaccta ctaccgttgg aaagcagctg tggggacaga gtatgctgac aaagcagtgg
    20041 agagaatccg ggagctttgc atccgtcata aatttcggta tggttaccgg aaaatcaccg
    20101 cactccttcg ggcagagcaa agaatgaatc acaaacgagt tcagcggatg atgcagcgtg
    20161 aggggctaca atgccgcgtg aggatgaaga aacgaaaggc cactgggcag cctgcaggct
    20221 gcttatccag cagaaaatct gctgaagcgg caattccttg cagaggcgcc cctgcaaaag
    20281 ctcgttacgg acatcaccta tttaccgttt ggcggaaaga tgttgtactt ctctagcatt
    20341 catgcccgct tgtaggatgc atcaaccctg tcatcatgcg catcaacgtc gttttcccta
    20401 ctccattcgg accaataaaa ccatatatct ttcctttgtc aagctgaaag gaagaatcgt
    20461 gaattacttg acgcttccca atcactttag tgatttgctg aacctccata acaacattag
    20521 gcattctttt tctccttcca aatctatcat aattgagggg aaggatggga ctaaaaagac
    20581 cccttccttc catttttcac tctaattcga ttaggattcg agttcaaatt ctatggttac
    20641 actgttcaac acaatgctcc aatattagaa aaacatttta cacctgctgt ttcagcacaa
    20701 gtgttggctg ttccgccgca catttcggtg cattaccacg ccaaacttgt tacttgaggt
    20761 tctactgaac ctttagactt gttaatttgt acatccaaat caaaaatatt gttttccatt
    20821 tttcccaaac tcctctcgat attcatcttt aataataaat acaataattt tgtgtaatct
    20881 aggaagctaa tttatatgaa agatatctca acagatcgtc acctattgaa gcatccccat
    20941 atgacatttt ctttatatgg ttagacactt tattcaggca ttatgccgaa aaaaatcctg
    21001 caaatgacta atcaaaactc cttgtatcga gtaaaaagaa atatatatat actaatacat
    21061 aattatatat agttaaatta tgtattattt aaaacctatt tggtaactaa ttttttatga
    21121 attcaagatt ggaagatata cttcaatatt caagatgcat aaaaggcctt gatccaactt
    21181 tgatgcgtgt cctaaaagta cacgaaaacg actttgggag taagatatag cgaagtccgc
    21241 tttacaacct ggcaacaagc aagtctagta agggattata aatacctatt gtagatggat
    21301 cctttcttga tggacgaaat catttcatac cgagtactcg ctcggtcgcg gtcttgaagc
    21361 tcaaatgagc cttaaatttc attcacttga acgtccagat caaataagtt ttagaaccac
    21421 accctgacca gatcgttatt caagtaattt ccatatatga caatacgtaa aatcttatgt
    21481 atgatcttag ttgacattat aaaaatttat ctaacagtga ttatttcctt cttacaaata
    21541 aaacaatatc acatgtttca aaatgtaaat ctattacttt atatgtaaac atacataaca
    21601 aaaaaaaatt aacaccaatt tattttaatg tatggttatt ccgttcccac actctcatta
    21661 gtctttacca tataaaaata gcccctcagc agcgctacct cagggctatc cctttataaa
    21721 atatacgttg cctatcttca gcaaccagtc tgtcacctac tccagctcaa cccactcgcc
    21781 gagcaacatg tccagctcgg cttgcagtcg ctcacgcgcg tcccacagct ccgccatgtg
    21841 gatcgtgtcg ccgcttgtgc cgagcagctc cagctcggca tccgccgctg ccaattctgc
    21901 ttctttggcg gcgatggtcc gctccaaccg ctcgctggat gcagcgggcg tgcgtgatgg
    21961 cttcgcggcc ttcgcttcgc gtgccccaga cccggcagcg gacgccccca agcgacctgc
    22021 cgactcggtg cgagcacgac ccttattggc tcccgaggtc gctcccgtac gcgcagcagt
    22081 ctctaggccc ttgctcgctg cactggaatg cgcagccgtg cccgagccgc caccagatgc
    22141 ggcacttgca gatgccgagc gtcccccggc atccccctca cttagcaagc gggcgttttc
    22201 cagctcccgc ttcttcgctc ggtactcatc aaagctgcct agataaaagg tcagctttcc
    22261 agcctccagc tcccacacgc gtccagccag cttattcaca aaatagcggt catgtgaaat
    22321 cgccagcacc gttcccgtgt aggtgtccaa cgcttcttcc agcgcctcgc gtgagtcaat
    22381 atccaggtgg ttcgtcggct catccagcac caacaaattt ggctttttca tgaccagcaa
    22441 cgccagccgc aagcgggacc attcgccacc ggacagcatg ctcacgggct taaacacatc
    22501 ggcaccgtaa aataaatact tcgctagcaa cccgcgtgcc tcgccttctt ccacccccgc
    22561 ttcttccttg aagtaagcaa gcacagtcgc ccggctattc cattctctct cttgctgcgc
    22621 caaatatccg tactctacgc gcgcacccca ctggaccgta cctgcatctg cactttcctg
    22681 accaagcagc agcttgagca acgtcgtttt gcctgacccg ttatcaccca gcaaggccac
    22741 cttttcaccg aattccaggc tgcccgttgc cccgtttaat atctggctct ctccataggc
    22801 tttaacaatt tcttcaaact gcagcacccg gcgaccggaa cgatcctcca gctttaagtg
    22861 aaattccgcc ccctgcgggt ccaatacagg ccgcttcacc agctccatac gctccagtgc
    22921 tttacgaatg gatgctgctt ttttaaaaaa cttttcgttg tcgccattgc gcccccactc
    22981 ttccaaacgc cgaatggcct ctttcatctt tttgattcgc ttttgctgtt ccttatagtc
    23041 ttcgaattgt agtagcaatc gttcttcctt ttccttaaca tagccgctgt agttcgtata
    23101 atacgtaaac gcctcgccat cctcaagctc aatcatttta acggcgaccc gatccagaaa
    23161 ataacgatca tgagatacaa ccacacacgc accagtatag ccttgcaaaa attgttccag
    23221 ccattccagc cctttcaaat ccagatggtt ggtcggctca tccagcagca gcaaatcggg
    23281 ccgtccgatg agttgtgatg ccagcgctat ttttgttttt tctccacccg acagcgagcc
    23341 aaagctgcgc gtgtacatgc ctttgggaat acgtagacca tccgctacct gatccatatt
    23401 tgcatccatt tcatagccgc cgttgcgctc aaaccgttcc tgtagggaag catacgattg
    23461 cagcagcttc tccagaagac ccgtatccgc tgccacaact ggatctgaca tttcccgttc
    23521 cagtgtgttc atctgattgc ggcaatcctt cagctcacga taggcgtaag ccagcgtttc
    23581 gtacacggtg aagctttcaa actccgccgg aatttgcggt aaatagccga ttttcgtatc
    23641 cttggcgatg acgagctgcc cttcatccgg gcgggacaag cgtgcgatta ggcgtaatag
    23701 ggtggtttta ccgcttccgt tgcggccgat gagtcccacc ttttctcccg tatggatatc
    23761 aaacgatgca ccatccaaaa tcagattggc agcgtggtat tttttcaatt gttgaccgtt
    23821 aactatatac atgttcaggc tctcctttat ttaggaagac ccttacccgg gtaacacaaa
    23881 aagagccgca ggagcaaccc cgcgactctt cggaagatac agcaatccgt tcgagttaag
    23941 gtaggcgtct tctcgcgatg tttacaacca tatgattaaa attggacaga cttctcccgt
    24001 tgtatggaaa agcatgaaca atgccagcca tagcaatcgg cagctggcta atacggttgt
    24061 tcagcatctc gtgattcacc tacctcacct ccttcttcat aattgtgtgt agtataacat
    24121 gtttgctcgt attataaaag agagcgatag tccagcaaac tatgaaacag agtggtgtcc
    24181 tctgacagtc tgggatgtcc cggctctggt aatcgaaaat acaccgcaga caaaagcaac
    24241 aattacaaat gccccaccca cccaagcgtt cgtggcaaca gattcactat tctcaatcac
    24301 tactcctccc aaggcagaac cgagagcgat cccgacctga agtgcggaga aattaaagct
    24361 ttgctgaata ctacccgatt cgggtgcatt ttcaataaga taactttgca tcgggggcga
    24421 caaggcccaa ctcagtatgc cccagatgat caatagtggc gcaaatacat aaatcgagtg
    24481 gattgagaat ggtagcagga acatcacggc gataaacacg cctacgacga ctagaatact
    24541 tttcgctgtg ccgaaccgat ctgccaaaga gccgccaata aatccgccgc tcactgccgc
    24601 caacccaaag acaaaatagg ccacactaat ccacgaagcg tttaagccca tcatattttc
    24661 taaaaacgga gtgaaatacg catataacgt gtaatggccc gccagtgtca gcgtggtcac
    24721 cagatgagca ctgatgactt taacattttt taaggatttc aattgatcac gcataggcac
    24781 aacatgttcc gtcggaatcc gctccataaa caagttgata acgatcatag caacgaccgt
    24841 caacaaggca atgattagga aaagcacccg ccagccaaac gcatttccaa tcagcacccc
    24901 ggctggaata ccaagtacga tggaggagct aacccccatg gagataacac cgagaacgcg
    24961 ggcctgatag gccttggaca ccactttgac tgcaatggtc agtgacaatg tcacgatcag
    25021 cgacccgctt gcagcggtaa tgatacggga tacaaacaag actgcataat tcggactcca
    25081 gaaggccagc agacttccca gaataaagat aaacatcgac cacaggtaca gtcgttttcg
    25141 ttcgattttg gcggtcaacg ccaacaaagt tggcccagca atagcgtaca cgagcgcata
    25201 gatcatgata agctgtcctg ccgtgcttac ggagacattc aaatcctgtg caatttgggg
    25261 cagcacgcca ccgataatca gctccaccaa ccccaccgta aaggtggcaa tcgttaaaat
    25321 aactactttg aagttcatta cattagctcc tttgctgtca tgtaaatccc tcgtattacg
    25381 caaaaaaatc ctgaccacaa gaaatgtaca agacgtacac tttttgtaat caggatttat
    25441 cggttcctgg tagagaccct caaaccatat tattgaggtt atacaaatgg ggcattcatt
    25501 tattacgcat tcacgaaggt tatagctatt actataaagg agcctgtggc taagttcaac
    25561 cccctacagc cgcaaaaatt cactcatggc acgatccgac agataaggta aatactcatg
    25621 accgtattcg tgatacagga gtatttcctt atctgatacg attttattgt acaccgcgaa
    25681 ctgcgtggag ggtggacaaa tgatatccga caaccccgtc acaaacaaca cacgaccacg
    25741 aatacgatct gccaaatgtt gaatgtcaat gtagcctagt cggtgaaaca gttcctcctc
    25801 gcgcagatgg ttcggatcaa accaacgaaa ataataaacc agttcttcat atgcagatgt
    25861 agtagcatcc agtgcccagg cccttttata gtccgacagg aacggatata ccggaactgc
    25921 catacgaaca cgtggctcca atgcagcgca ggcaaccgtt aaggcccctc cctgggagca
    25981 gccaaatgcg ccgatccgtt caggatcaac ctgctccata gacatcagaa tgcgcaccgc
    26041 ctgtaccgta tccaaaaata cattgcggta atacaaccga ttcggatccg ggtcgtcaat
    26101 ccctcggatg atatgcccgc gcaccgtcgt tccctgaacc tgcaaattgt cctcggacag
    26161 ccctccttgc ccccggcaat ccatagccag cacagtgaat ccgtgtgccg cgtagcttac
    26221 cttgtcgaac cagtcgccac tgtcgcagga atacccatga aacatagcca aggctggacc
    26281 ttgttccgta agatgcttgg gacgagccag cttcccatga acctttgctc cgcctactcc
    26341 ggtaaaatat agatggtaac actctaccag cggagagaca aaattagcag gctctagtgt
    26401 atattccagt ggctgctgct ccagctccag taacgcccgt tc
//
