LOCUS       NZ_CP071875            27353 bp    DNA     circular CON 27-MAR-2024
DEFINITION  Paenibacillus polymyxa strain SF05 chromosome, complete genome.
ACCESSION   NZ_CP071875
VERSION     NZ_CP071875.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5459135)
  AUTHORS   Chen,B., Zhao,F. and Han,H.
  TITLE     The complete genome sequence of Paenibacillus polymyxa SF05, an
            antagonistic strain isolated from maize sheath
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5459135)
  AUTHORS   Chen,B., Zhao,F. and Han,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Institute of Maize and Featured Dryland
            Crops, Zhejiang Academy of Agricultural Sciences, Tangxi Village,
            Chengdong Sub-district, Dongyang, Jinhua, Zhejiang 322100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. v3.6.2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Nanopore; Illumina PE150
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028751565.1-RS_2024_03_27
            Annotation Date                   :: 03/27/2024 02:05:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,074
            CDSs (total)                      :: 4,919
            Genes (coding)                    :: 4,764
            CDSs (with protein)               :: 4,764
            Genes (RNA)                       :: 155
            rRNAs                             :: 15, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 108
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 155
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 76 of 155
            Pseudo Genes (incomplete)         :: 112 of 155
            Pseudo Genes (internal stop)      :: 26 of 155
            Pseudo Genes (multiple problems)  :: 50 of 155
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:54:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1081950
            Orig. end                         :: 1109303
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071875.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27353
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..27353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..24366
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14366](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(126..144)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 25.26"
                     /tool="antismash"
     misc_feature    complement(364..377)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.15"
                     /tool="antismash"
     gene            445..1209
                     /gene="aroD"
                     /locus_tag="J4I02_RS05105"
                     /old_locus_tag="J4I02_05040"
     CDS             445..1209
                     /EC_number="4.2.1.10"
                     /GO_function="GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426256.1"
                     /locus_tag="J4I02_RS05105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05040"
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="WP_274484180.1"
                     /transl_table=11
                     /translation="MAKIVKVKDVLIGEGAPKICVPMVGETLEQLKEEATYLRTLDLDI
                     VEWRVDFFEHVEDLEKVKVALHEIRSILANVPLIFTFRSAREGGEKEISAASYVELNRT
                     IAETGQVELIDVELFNEEADVKTLVEAAHKHNVYVIISNHDFHKTPSKEEIVSRLCKAQ
                     ELGGDLPKIAVMPSNTADVLTLLDATRTMAEEHADRPIITMSMAGKGVVSRLTGELFGS
                     ALTFGAAKKASAPGQIPVTELREILTVLHSHS"
     gene            complement(1323..1895)
                     /locus_tag="J4I02_RS05110"
                     /old_locus_tag="J4I02_05045"
     CDS             complement(1323..1895)
                     /EC_number="2.7.1.71"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004765 - shikimate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819867.1"
                     /locus_tag="J4I02_RS05110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05045"
                     /product="shikimate kinase"
                     /protein_id="WP_274484181.1"
                     /transl_table=11
                     /translation="MQNNSEIPLKEQNIVLIGFMGVGKTTIGSHLARKLYRDFVDIDQE
                     IEQEYNMPTTEIFKTYGEKRFREIEKEHILKLCSNTRLKIISVGGGAFLQEEVKQACLA
                     SSIVFFLDLNWDSWQDRLKMLIDTRPNLQNKTLGEIEDLFRSRQDIYAVNHSKIDTDQL
                     DAEEVADYIIQTLNLGWELYEPTRGLN"
     misc_feature    complement(2099..2108)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(2259..2272)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.98"
                     /tool="antismash"
     misc_feature    complement(2302..2317)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            2448..3140
                     /locus_tag="J4I02_RS05115"
                     /old_locus_tag="J4I02_05050"
     CDS             2448..3140
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819868.1"
                     /locus_tag="J4I02_RS05115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05050"
                     /product="pectate lyase"
                     /protein_id="WP_274484182.1"
                     /transl_table=11
                     /translation="MKTNTANILKKGISIALSGMLVALFVGNYSAHAAPEVVHKTILVK
                     AGEVYDGKGKTVVADPDTLGDGSQKEAQKPIFKLENNATLKNVIIAAPAADGVHVYGNG
                     TISNVTWEDVGEDALTLKEPGTVNITGGGAFHAYDKVFQINAEGTINIKNFRADDIGKL
                     VRQLGGSTFRVNMTLDNSDISNVKDSILRSDGPNSKAKITNTRYHNVKQLFKGFKSGNT
                     SESGNTQY"
     gene            3296..4333
                     /locus_tag="J4I02_RS05120"
                     /old_locus_tag="J4I02_05055"
     CDS             3296..4333
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013308931.1"
                     /locus_tag="J4I02_RS05120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05055"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_274484183.1"
                     /sec_met_domain="APH (E-value: 5e-12, bitscore: 44.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVLLHFIQKSWVAMNPFHQYVNVDGTLNDTLVQNREILYTGTNG
                     RHVERFYVSSSESYIFKPLTNDDQEGRERWVYEHVLPMLSPIYPRLLAWSDVEAFGGGE
                     WMVFEDLGPLHHLHADETLLRAIGLVAWWHALPTDRFVGMPLRGPKPLIQEMVSELYTR
                     KPDVLKLCSSLGLSKQQMQRMYVQLEHVSFSQQLVLSHGDLHPGNYALSGERLMVLDWE
                     HAHLNTPLWDVYHLIDMSHPLFPRRMTSELRIRMLDTYVEQLEMLGIRVDRTAFMLEYG
                     MFAVVFSLWMLLLITSDLQRIGTNLHRNGDKWSKEQLESQLDETLACLNQCAALMDWGQ
                     AQPCR"
     misc_feature    3312..3325
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            4388..5386
                     /locus_tag="J4I02_RS05125"
                     /old_locus_tag="J4I02_05060"
     CDS             4388..5386
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279969.1"
                     /locus_tag="J4I02_RS05125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05060"
                     /product="glycosyltransferase"
                     /protein_id="WP_274484184.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.3e-11,
                     bitscore: 41.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGLVMRKIQFAEAQGPRIFAERLKQIGAELGVDIVFVSPERH
                     VSSHDWLPGYEHEKGDLVNYDIVLDQLHEQQIEHVIYTVSGFTYLNLFFKNSVLFPHSF
                     PDPALTGYEMMKPFYQIVDKAIVQTAFLKQEMASKFGVTDVTVIPIGFNERLVEEHFDP
                     SQVVENRVMWIGRDEENRRPDLVLEYARHNPDKDVYMVFGGERYKESMKKYEIPGNVKL
                     QFALTQDEVFALMNTAKVYWSCSKFDTFAMPLTEALAMGKIVVKPEHPCYGHISSTHSF
                     SGNEKNWFELVNMAAASPRRVSTENQAYAMEQFSSQVMKQGYREFFDHWLS"
     gene            complement(5597..6805)
                     /locus_tag="J4I02_RS05130"
                     /old_locus_tag="J4I02_05065"
     CDS             complement(5597..6805)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369570.1"
                     /locus_tag="J4I02_RS05130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05065"
                     /product="MFS transporter"
                     /protein_id="WP_274484185.1"
                     /transl_table=11
                     /translation="MSTQENMTANRFPPSLLWLTLGAFAIGMTEFVIMGLLPNVAHDLH
                     VTIPQAGQLITSYALGVAIGAPVLTVLTHKVPQKKLLCLLMIIFILGNLFSVIAPNYEF
                     LIAARMATALSHGTFLGAGSLIAARLVRPDKRAGAISMVLTGLTVANIIGVPFGTFIGQ
                     QLGWRASFGAIVVIGLISLFGIIRYIPVIHQDKPSSLKQEVKSLFNPKVLLMLLTGAVG
                     CGSLFTVFTYITPLLTDISGFAEHSITWILVLFGLGVTIGNIVGGKLADWKLLPSLIAN
                     YAVLAIILAILTFTLQNKVLAVITVFIWGIAAFGIMPGIQVRIMNLAYEAPLLASTSSH
                     SALNLGNAGGAFIGGVVINQMGLAAIPWVASLITVGGLLLMLVSYIVDRKAAHPEAIAE
                     IQS"
     cand_cluster    6775..27353
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    6775..27353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[16774:17353](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16775..17353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            7021..7944
                     /gene="cysK"
                     /locus_tag="J4I02_RS05135"
                     /old_locus_tag="J4I02_05070"
     CDS             7021..7944
                     /EC_number="2.5.1.47"
                     /GO_function="GO:0004124 - cysteine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene="cysK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819871.1"
                     /locus_tag="J4I02_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05070"
                     /product="cysteine synthase A"
                     /protein_id="WP_274484186.1"
                     /sec_met_domain="PALP (E-value: 1.4e-70, bitscore: 236.2,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPKVVHSITDLIGDTPCVRLQRLTGPQDAEVYVKLEYFNPSGSV
                     KDRAAGNLIAEAEKAGHLKPGGTIIEPTSGNTGIGLAMNAAARGYRAILVMPSNMTKER
                     INILKAYGAEVVLTPAEERMPGAIRKAIELGAEIEGSFIPHQFENEANPDIHRTTTALE
                     ILEQTEGKLDVFVASSGTGGTITGTGEVLRQHLPDLRIVVVEPKGSPVLSGGKPGPHKL
                     VGTSPGFVPTVLNTEVYDEIVQVSDEDAITMTRAIAAQEGILVGPSSGATIWTAIQEAR
                     RLGAGKRVLCIAPDTGERYLSMGIFG"
     gene            8273..8527
                     /locus_tag="J4I02_RS05140"
                     /old_locus_tag="J4I02_05075"
     CDS             8273..8527
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J4I02_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J4I02_05075"
                     /product="hypothetical protein"
                     /protein_id="WP_274484188.1"
                     /transl_table=11
                     /translation="MSIIAYIRENLKSLTVHIPFFDLICLFSLAIIYMMLKTHKPYIGG
                     GSEGYYCATVEAVTEEMKNYIVNQFTEEKNESFRIENEF"
     gene            8827..8988
                     /locus_tag="J4I02_RS05145"
                     /old_locus_tag="J4I02_05080"
     CDS             8827..8988
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="J4I02_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05080"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_274484189.1"
                     /transl_table=11
                     /translation="MKVDQIFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCIC
                     TGSCSNCK"
     CDS_motif       8827..8895
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKVDQIFDLDLRKSYEASELSPQ"
                     /locus_tag="J4I02_RS05145_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8896..8988
                     /prepeptide="core"
                     /locus_tag="J4I02_RS05145_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.70"
                     /molecular_weight="2943.6"
                     /monoisotopic_mass="2941.6"
                     /core_sequence="ASIIKTTIKVSKAVCKTLTCICTGSCSNCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKVDQIFDLDLRKSYEASELSPQ"
                     /leader_location="[8826:8895](+)"
                     /alternative_weights="2961.6"
                     /alternative_weights="2979.6"
                     /alternative_weights="2997.7"
                     /alternative_weights="3015.7"
     gene            9055..9996
                     /locus_tag="J4I02_RS05150"
                     /old_locus_tag="J4I02_05085"
     CDS             9055..9996
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686236.1"
                     /locus_tag="J4I02_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05085"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_274484191.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 7.8e-22, bitscore:
                     76.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKPNIYNWHVARLTDHFSCGATVGQLLTILFIDTGVDKSHSEIQ
                     GNLVEAECKSFVPYEPCLSDYVGHGTQMVSSVTGKYILKGICPFARVVVYKITDKKGIS
                     KLEWLYRALEEGIAKGYPIINISYRTEYEVDLFEFNRFQALVDCANAQGIWVVCSAGND
                     GRDITQEYRVPANLKGVYPIGSTNKNGDISGFSNTLSGQFFAPSGDEYEINYNNDWVMV
                     AKSSFDTEDYLYKVLGFDKAYTVGIGTSIASALFSGVVASLSGELIAQGMNAGRTEMEC
                     LLRQGARLIDVQRNYYEVSLAGSIRALRQMRG"
     gene            10001..13084
                     /locus_tag="J4I02_RS05155"
                     /old_locus_tag="J4I02_05090"
     CDS             10001..13084
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686237.1"
                     /locus_tag="J4I02_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05090"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274484192.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.2e-114,
                     bitscore: 379.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8e-12,
                     bitscore: 43.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-25, bitscore:
                     89.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENFEISENYMYRKTLLGMEYYTRIFDHEQLDDDEYLDKLVRFV
                     QQQGLMDSIYVSSPSTYAALQSLEQGRALKSKKKRNLILSLSKFISRAICRPTPFGLFA
                     GVGISRFGNTGGAGEHVVWATPDYSLIYRLIGLFHGDADVRNELRLSVNNTSYIDHHRL
                     VISYQTLFAADQEERSTENISILKTPVIDFIMKILDKEQQTFLQLMQAIKDAFGVDDTI
                     STDFLQQLIEQGFLVSEMIPNPRDSAPLEHLIRTLKLLAAPKAAYYADILERVGHAIQD
                     ITIAEDKREGIEAVRKLVQLILPDYQGDLVKIDVRLNEANEIHLSDSDRQALAQVASIL
                     SMLSTYRKEDTLSDYRQQFTEKYGVYEEVPLLQLFSKTLGLGKPEEYKSHYQNGDKYRH
                     KDEGRFRQLKALIAEWQTEALANHSDIVLDEAKIQQLSELSLENVYVSFDLYYSCMENE
                     QGEVTFYLNNRAGSLEACQSFGRFAYMFDKDSRDEIFRFVRNPKDQKAGESAAEISFYP
                     FSPKITNIMTAGPTPDQSMDMATFPKNRNLDISQLLVGVEDSGYFYLKHRETGELVFPK
                     LSSMYNTELAPYLIRFLNDINLQYQTGWSHLEEYLYDSSFTPRVTYKNIIICPKKWTLY
                     ADKRFQSEEQFLAFLEDWIIKYNIPRYVYLVELDNKLLLDLDRHHHRKLLHKEYTRNPE
                     GKAAVIMETEKELFASVNRYMEECVFFCKSPMFQYLPIDRLSAQATDKSLNKVLSSSVN
                     AVYYPGSDWISLQVYYNQELLTDLLGSAFKTFMDNSAEYFIDQVFFVQYADKEPHIRLR
                     CKMSGSVQHQRFTALNYVFDFLNTVTSSGLVSSYSVVPYRPEILRYGGAAFIEQAERLF
                     AIDSYLVSGYYAGKRSINGTDQMLFCCTGLFEVVNCAYPLAEDQLKAMAAIIDPKKFRQ
                     EYREHKEALFQRIQQTRSISLPASDKDDRLRQYAAYFTAIREADDRTNYYDDIMFSIMH
                     MFCNRVFGLDREKEELALHLCYYSLEDYLQVSKYHVAY"
     aSDomain        10448..10726
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_J4I02_RS05155_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.60E-14"
                     /identifier="RREFam001.1"
                     /label="J4I02_RS05155"
                     /locus_tag="J4I02_RS05155"
                     /protein_end="242"
                     /protein_start="149"
                     /score="43.9"
                     /tool="antismash"
                     /translation="LSVNNTSYIDHHRLVISYQTLFAADQEERSTENISILKTPVIDFI
                     MKILDKEQQTFLQLMQAIKDAFGVDDTISTDFLQQLIEQGFLVSEMIP"
     gene            13095..14366
                     /locus_tag="J4I02_RS05160"
                     /old_locus_tag="J4I02_05095"
     CDS             13095..14366
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426262.1"
                     /locus_tag="J4I02_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05095"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_274484193.1"
                     /sec_met_domain="LANC_like (E-value: 2e-49, bitscore:
                     166.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVKQVPGNLSEIVRQSAEIYKDIDTVTLLIKKHAMHDYPEMELI
                     SLASGYPGISLLLDKLDEVYPGEGWAALAFKYNQEIVRLIGNIPFHSLSLYTGLAGIIY
                     LFNECSRGSTRYTNVLSQTLDMFLSSYEEFYEETRGKLEDSLIEDSDLDLISGWTGIAA
                     ALMEVKERHDRYAGKLDAVLLKILQLITDAVGKLRYFEQLPEQTIYYNLGMAHGITGAI
                     NLLAVAHLRRYPLTGLREVLEVAKAFLLGSIREWNGTLVIPNMFTPDESAGTSLNPGYH
                     RDAWCYGTPGASVAMFRLGLALEDKALQQQALQLFNTVYSRPDSLRKVISPTICHGYAG
                     LVLIQHYFSRAAAMPFKDEFLHRLLSYRNIGEGVPFIDLEGSVDDPLSLDKVGLLDGCA
                     GVLLTLLTCDNENLSTWKQMLVFS"
     gene            14382..14939
                     /locus_tag="J4I02_RS05165"
                     /old_locus_tag="J4I02_05100"
     CDS             14382..14939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819877.1"
                     /locus_tag="J4I02_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05100"
                     /product="DUF5823 family protein"
                     /protein_id="WP_274484194.1"
                     /transl_table=11
                     /translation="MFILLKEIITVMVGLITDFLSFQLDAYFYIWFLVLFISSLAATLV
                     QRSEGTITYSKAECVGINVLVVVLYLVIGTILARYFASFEDQQIVAEDKIMLYKISFML
                     TSAVIIVDIILDRLKRGRKFSYSLEFLAGSAVCFLLFQLSNQTDWIGTKLSLSYIVMVA
                     IAAGVYTMAMKFLLEYENHKEK"
     misc_feature    complement(14389..14402)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            14954..16747
                     /locus_tag="J4I02_RS05170"
                     /old_locus_tag="J4I02_05105"
     CDS             14954..16747
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426264.1"
                     /locus_tag="J4I02_RS05170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05105"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_274484195.1"
                     /transl_table=11
                     /translation="MELNMESTAYKKIGEEQQTAHSLLELTKIARWPKFALAWSIIFTL
                     ISAAFSLVLPIITGKLVDKISAMELTIQTAAVLISLFLAGGILNAVSSLLLRYVGSKFF
                     QELRLKIWEKIIHLPVNYFDNNENGKIISRMTNDLAIVSNFLAITLPSILADVLMVTGC
                     IIMLFVLDWRLMSVLVALIPITALLIYPIGRRMNKVAVEAQDAAADFSGELAKILYNIR
                     FIKATTSEQLEMKYTREILGRIFRLNIKEGILSAVIEPIVTIVIMLALVGMFWYGSAGI
                     AAGHITTGALVSMIFYLFTMVSPLTQLSSFFSQYQKAKGASKEIHTIYNQQDEKQEELG
                     NVPDMKSHDQNSDILHFANVSFSYNQGQPVLSNVELAFRGCTTTAIVGPSGSGKTTIFS
                     LIEKFYSEYNGKIYYNNVYLDKIRTEEWRRKISYVMQDSDLLVGSVRDNLVYGLNRDAD
                     DHEIYAALDTVGLKEVIHQLPDGLDTFVGERGVKLSGGQKQRIQIARCLLSDHEILLFD
                     EATANLDSESEQLVHDVIKLLSKNKMTIVIAHRLSTIYKADQIIFLDKGEVTGVGTHHE
                     LMSWHDKYRDYVQFQLPAQLS"
     gene            16775..17353
                     /locus_tag="J4I02_RS05175"
                     /old_locus_tag="J4I02_05110"
     CDS             16775..17353
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686238.1"
                     /locus_tag="J4I02_RS05175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05110"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_274484196.1"
                     /sec_met_domain="AgrB (E-value: 1.4e-31, bitscore: 107.5,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTWIVDKYFQDEELEAEKRAYVLYYLENILAGTEKILLVLVSAC
                     LLSVLAETAAILLSYTVVRRKSFGWHARKSHHCTWVSLLTFVFVPWLLKEVEWNRIFLA
                     TLCLLSIILIARYAPADTECNPLVDPKFRRACRLQAIFLSIVFVFVAIALDFYPWLIFG
                     LFLEAVVITPVFYSIMRRSYANYEQYQEY"
     gene            17582..18820
                     /locus_tag="J4I02_RS05180"
                     /old_locus_tag="J4I02_05115"
     CDS             17582..18820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819882.1"
                     /locus_tag="J4I02_RS05180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05115"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_274484197.1"
                     /transl_table=11
                     /translation="MNYKLLLFLVMYYFIGITALDNFGLIVYLFLFVLLALYGWLTDKC
                     ESLWVIGFYAILTIFITTLLGYFITVISYAVPYEYKNKWTAPFLTACSPPLIYLALRKL
                     VSYLFPTPAVRLLKLYRIKLIVGASLILALGIIGLGLIIYSECESNNPYPSRLKIVLML
                     IGLTSIFLMTINWLYRFLRERELEKNKTEQYLQLEAYIMEIEKMYEDIRGFRHDYTNIL
                     LMLDEGIRTGDLAMIRRIYESSIQPTASQLNGYSYSLDNLINLDVSELKSIITSKMLVA
                     KKRGVDVKLEIESGISEMYMDIIDLCRVISCFLDNAIDAALETCNPSITIVLIHEDDIQ
                     TVTIRNSYNQSALDGIKVNDLYKRNFSTKADNRGLGLYNIAKVLRSNKYVTLDTKKEPD
                     FFTQTLIIKRATS"
     gene            18817..19596
                     /locus_tag="J4I02_RS05185"
                     /old_locus_tag="J4I02_05120"
     CDS             18817..19596
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819883.1"
                     /locus_tag="J4I02_RS05185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05120"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_274484198.1"
                     /transl_table=11
                     /translation="MNIFILEDQFIQQRIMEKMVRKSCEELGICCSNLIITSKPDLLLF
                     ESKACANNLYFLDIEISGCQMKGLEVAQEIRKYDMYGHIVFVTTHDHLSPLTFQYKVAA
                     LDFIIKDATQDEMEKKVREVLAVAHQRKPVLDVNDWFILDNKFTKFQISFSSIYYFETT
                     GVPHKIRLVSENRTLEFYGDLKDIEAKDPRLFRCHRAFIVNLMKVESIDKSKKEIIFQT
                     NQNSGEARRIIPVSRQLLKHLLDKMGDRSLLNRPVYE"
     gene            19643..20401
                     /locus_tag="J4I02_RS05190"
                     /old_locus_tag="J4I02_05125"
     CDS             19643..20401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426268.1"
                     /locus_tag="J4I02_RS05190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05125"
                     /product="TraX family protein"
                     /protein_id="WP_274484199.1"
                     /transl_table=11
                     /translation="MEQRLSVQAEVKGIDATSLKLIAILAMLIDHIGGLFFADFLGFQV
                     VGRITLPIMAFFVAEGYIHTRSFKKYTMRLAVTGLASVVPYGLVFKDWYSSGNIMLTLL
                     MGLLAIWFYDNTTNPVLKYLAISALCVVSFLGDWSVIGVLLVLAFYVARKQQKIYNGWI
                     IAIIALMFIFGVIIIWAVPDSLSILGINASTMNEYLYPFAIGGACIFALPLLSRYNGER
                     GKGSRTFFYLFYPLHLLALYLLKLAIDYYI"
     gene            20488..21465
                     /locus_tag="J4I02_RS05195"
                     /old_locus_tag="J4I02_05130"
     CDS             20488..21465
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426269.1"
                     /locus_tag="J4I02_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05130"
                     /product="aldo/keto reductase"
                     /protein_id="WP_274484200.1"
                     /transl_table=11
                     /translation="MKIMPLQKRGISDSRLVLGCMPFGGEWSHAPFTQEHVLEAERAVE
                     AARSIGITMFDHADIYRMGKAEEIFGRILKGQPGLREQIVIQSKCGIFLPDGTLPGRFD
                     FSYAHIMESVDGILKRLGTEYLDILLLHRPDPLVEPEEVAKAFSELTASGKVRHFGVSN
                     MNVSQIRFLERSLTEPLITNQLEMSLAHLHFVDQTVHVNQQAGTNVHFGEGLLEYCQTE
                     DIQLQAWGPLAQGRFSGGSLEGEPEHVVKTAELVQKLASEKETTREAIVLGWLMKHPAR
                     IQPVIGSANPERIKASQDAERQSELMTREEWYELYVSARGQALP"
     gene            complement(21623..22423)
                     /locus_tag="J4I02_RS05200"
                     /old_locus_tag="J4I02_05135"
     CDS             complement(21623..22423)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819886.1"
                     /locus_tag="J4I02_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05135"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_274484202.1"
                     /transl_table=11
                     /translation="MSLFEKIFNYQIVSRLDESGAFATTSQERIWLKSMLADSAATEAF
                     TPSTLDKLRQLLADDEPLEADGSLREKAGVPAASIYHPLLRELRPILRSRSGICITYKL
                     RNGRMHERMSGFPYKLEFSMVKKEWSLLWYNRRHRALMSTKLSNIVNITENVLLREEAE
                     KFSQRILGILESRKEQGIIEIIPVYNGEMSRILYAFSCFEKEVEYVQEADTYRITLTFQ
                     ADECEYVLSKIRFLGKRVKVIQGSRLISRMKETTAKALARYEEE"
     gene            complement(22398..23723)
                     /locus_tag="J4I02_RS05205"
                     /old_locus_tag="J4I02_05140"
     CDS             complement(22398..23723)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428946.1"
                     /locus_tag="J4I02_RS05205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05140"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_274484204.1"
                     /transl_table=11
                     /translation="MARESFDKEIQFLRMLTLTSGAYNRQQFADRLGISVHTFDKTIRR
                     LKEIVQSVQQQLPAEQGHDFNEMLRFNYYESADPLLLFLFRAKSLKESESVRLSLLLTA
                     LQSQPMTTMELLDACCNGLPSDSSLPDEKTIRSDLKYLVEVGVVRKEPGGRPYRYAVRN
                     DLVTELTDEELLDLYDFVDIMANTQLPSVQGYLLRDHLKKAMRRQLGDREMAEPFLYKY
                     HYYSRILDEAHIHPLLHAIRQRRCVTFLYFSTSKRSMYGSRNTNPLFEKETEGREHTIL
                     PLQVIYDHQYGRWYVLGHVGGKGIMKFRMEGMTQMVEGKPVPEQLYADLLAVLEEKMRF
                     SWLVDTGRPVKVRVRFFNPEGAKRNFIRERVLSQGQWGTIAEEESESFIYEITVNGITE
                     IKPWIRSFGSSCEVLEPQRLRKEFRQEWKELQAYYEPVRENI"
     gene            23923..25491
                     /locus_tag="J4I02_RS05210"
                     /old_locus_tag="J4I02_05145"
     CDS             23923..25491
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369575.1"
                     /locus_tag="J4I02_RS05210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05145"
                     /product="limonene hydroxylase"
                     /protein_id="WP_274484205.1"
                     /transl_table=11
                     /translation="MFGRRKNEVLYPWVGKLSIYETIKQGLDPQGRLTDDHLPDDEEYW
                     AGHTMRWVAGGLDGAFGHHGAGGDGETNKIKDLAQLLSRQCRKPGMKTRRETYVRLMEE
                     NALSLIDPLLDAVREHPAIQPERLYEEARWLAEHGAHRNVVKVGIALLGLLETEQHHEL
                     ILTLAKHDEFTLYAAVAIRNISEQANEQLYRLASQVHGWGRIHVVERLEPARQEIRDWL
                     LREGFRNNVMYEYLAYECAHKGELHTAMAVPHIDQELFDGAGDILSALLAAGGPAESID
                     DYEHAAMVIGNYLRHAKAMCTTVKHFTIIMDIADFLGEEDDSWEARYEYEWTPELRKRY
                     ASICQQMMNDPQWVKLVEQELQHADSSHLHCAIRVARMLALDVWPVLFDQLSKYPVKPN
                     LYFELIKTEDEQRARKLMAFAEKHLPLGEIASGPADVPGFGPEYEAHQCLGMLLQLLAS
                     YEGMGQELVAAGLWSPLTSNRRAALHVLKVWPSEMWGEETTERLRRLSVAETEESIREQ
                     IREIL"
     gene            25511..26329
                     /locus_tag="J4I02_RS05215"
                     /old_locus_tag="J4I02_05150"
     CDS             25511..26329
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010347422.1"
                     /locus_tag="J4I02_RS05215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J4I02_05150"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_274484207.1"
                     /transl_table=11
                     /translation="MTDVKHGQGLIQPDMRETILRELRALEQEEQVRIVYACESGSRAW
                     GFPSQDSDYDVRFIYVRPIEWYLSIFDKRDVIERPISDLLDINGWDLKKALHLFRKSNP
                     PLLEWLQSPIPYLEQYSVADQIRAISPLTFSPKSCMYHYLNMARGNYRDYLQGEQVKIK
                     KYFYVLRPLLACGWIERYNSMPPMEFVDLLEEFIPADTELYQVIGHLLQRKKAGEELDM
                     EPRLSVVNGFIQQQIAYFEQKAPLFQHMESGRDQQLDDLFRAAVNEVWKA"
     misc_feature    26751..26765
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.2"
                     /tool="antismash"
     misc_feature    27068..27084
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.81"
                     /tool="antismash"
ORIGIN
        1 cttttcaagt caggggcggc ggccattatt tgtgcgagtg tcatcgggtt ttcaatatca
       61 ggtgtacttc agctgacatt aaccgtaatg agtgaatttt ttagtcaacg aaaaggacag
      121 attacccggt ttgtttatac agcaacctcg ttgtcataca cgatcattcc tgtgtttaca
      181 ggctttctgc tgaagcattc tcagatatcg agtgttttta tgctagctat tattgtgaat
      241 gtgctaggga tcgtactggc ggtgtttgtt aattttcggt acagtttagt ttttccagca
      301 agttgcaaat tgtcccctaa aatctacttg aacccaaata aatgccgact ggacctaatc
      361 atctgcatgc ttattcagaa tgcgttatac tatgaattat tgtacatgct cgacttgaaa
      421 ctgtaatttg ggagtgagat agagatggct aaaatcgtaa aggtgaagga tgttctgatc
      481 ggtgaaggag cgccaaaaat ttgtgtgccc atggtgggag aaacgttgga gcagttgaag
      541 gaagaagcta cttatttgcg tacgctcgat ctggatatcg tggagtggag agtcgatttt
      601 tttgagcatg tagaggattt ggaaaaggta aaagttgcct tacatgaaat tcggtctatt
      661 ttagcaaatg ttccgctcat atttacgttc cgtagcgctc gggaaggcgg agaaaaggaa
      721 atcagtgcgg cgagttatgt ggaattgaac cgtacgatag ccgaaacggg gcaagtcgaa
      781 cttattgatg tagagctttt taatgaggaa gccgatgtga agacgctggt agaagcagca
      841 cataagcata acgtgtatgt gattatatct aatcatgatt ttcataagac gccgtcgaag
      901 gaggagattg tgtcccggtt atgtaaggcg caggaattgg gaggcgatct gcctaagata
      961 gcagtgatgc cgagcaatac agccgatgtg ctcactttgc tggatgccac gcgtactatg
     1021 gcagaagagc atgcagatcg gccgattatt acgatgtcga tggcggggaa aggtgtcgtg
     1081 agccgcctga ccggagaact gtttggttcg gctctgacct ttggtgccgc taagaaagct
     1141 tccgcaccgg ggcagattcc agtcactgaa ctgagagaga tattgacggt gctgcatagc
     1201 cattcttaaa agatggatag cactactcgc cagttagtaa ttagtaatgt attcgcaatg
     1261 aaccaaaaag gaaggcccct catgcggtaa gcatgctgga gccctccttt ttggtgtaat
     1321 tcttaattca atccccgagt aggttcatat aattcccaac ctagattcag cgtttgaata
     1381 atatagtctg cgacttcttc cgcatccaac tgatccgtat cgatcttgga gtgattcacc
     1441 gcgtaaatgt cctgtctgga acggaaaaga tcctcaattt cccctaaagt cttgttttgt
     1501 agattgggac gggtgtcaat cagcatcttg agccgatctt gccaggaatc ccaattcaaa
     1561 tccaagaaga aaacaatcga tgaagccaaa caagcttgct tcacctcttc ctgtaaaaat
     1621 gcacccccgc caacggaaat gatttttagg cgtgtgttgc tgcacaactt caaaatatgc
     1681 tctttttcaa tctcacggaa acgcttctct ccgtaagttt tgaaaatctc tgttgttggc
     1741 atgttgtatt cttgttcaat ctcctggtca atgtccacga aatcgcgata cagcttgcgc
     1801 gctaaatggg aaccgatcgt tgttttacct acacccataa agccgatgag cacaatattt
     1861 tgttctttta atggaatctc actattgttt tgcacgataa ccactctttt ctcaccagta
     1921 atgttgagat gtgacgcttc aaagcactaa atacattata cgttcatcaa acgtgtcatt
     1981 caatagtata gactacatca aaaatgcgct atagaacaaa atgaggttct gattaccatt
     2041 gtagtgacat agagcacgca tacgagacta gatactcagc aatttgatgc gtaaattgtc
     2101 aaaaaacaaa cttgtacaag tataaaagag gcaattttgt gtacttaatt gaaaaaaagg
     2161 acatattttg ccgagaaata tattgaaatt actggaagtg tgattataat agagttatac
     2221 aaattgtaaa tgtaatcgct ctatttacaa tttgtgcttt atattattta taaaacgaaa
     2281 ttactttgaa ccaaaaaccg agtatacata tgcaaatagt tgaatgatgc ttcatagacg
     2341 tgtattggtc attgggttca ttgtgcgaag gtggtgatac ggtctacccg ttctagtcaa
     2401 cgaagagttg gaacaatgaa aaatatctac gagagggatg aattgacatg aaaacaaaca
     2461 cagctaacat attgaaaaag ggaatcagta tcgctttatc aggaatgttg gttgccttat
     2521 ttgtcggcaa ttattctgca catgcagctc cagaagtcgt tcataagacc atacttgtta
     2581 aagctggaga agtttacgat ggtaaaggca agactgtagt ggctgatccc gataccttgg
     2641 gagacggaag ccagaaagag gctcaaaagc ctattttcaa gcttgaaaat aatgcaaccc
     2701 tgaaaaatgt gatcatcgct gcccctgctg cggatggggt gcatgtatat ggcaacggca
     2761 caatctccaa cgtaacgtgg gaggatgtcg gtgaagatgc attgacgctt aaggaaccag
     2821 gcacggtaaa cattacgggc ggtggagcgt tccatgcgta cgataaagta ttccaaatta
     2881 atgccgaagg cacgattaac attaaaaact ttagagccga tgatatcgga aaattggttc
     2941 gccaacttgg gggctctaca ttcagagtga atatgacttt ggataactcg gatatttcca
     3001 atgtaaagga ctcgatcctg agatcggatg gtcctaacag caaagctaaa attacgaaca
     3061 ctcgttatca caatgtgaaa caattgttca aaggctttaa atctggtaat acgagcgagt
     3121 ccggcaatac tcaatattaa tcggtataga atagagtaag gataggagta tggatgtgat
     3181 aaggggctgc caacaggtcg cgtgatctgc ttgggcaagc ccctttttgg gtgcagcgag
     3241 ttacccccag ctacccctag atgatctggg cttcgttcgg aacgaggact gtgatatgat
     3301 cgtgctatta cattttatac aaaaaagttg ggtagctatg aatccttttc atcaatatgt
     3361 gaatgttgac ggcactttga atgatacgtt ggtgcagaat cgtgaaattt tatatacagg
     3421 tacgaatggt cggcatgtgg aacgttttta cgtgtcttcc tctgaaagtt atatatttaa
     3481 accgctaacc aacgatgatc aggaggggcg ggaaagatgg gtgtatgagc atgtgcttcc
     3541 tatgttatcg ccgatctatc cccgattgct agcctggtct gatgtagagg cgtttggtgg
     3601 aggagaatgg atggtttttg aggaccttgg tccgttacat catctacacg cagacgaaac
     3661 tttattgcga gctattggac ttgtagcatg gtggcatgct ttgccgacgg atcgttttgt
     3721 tgggatgccg ctgcggggac caaagccact tattcaggag atggtgtccg agctatacac
     3781 gcgcaagccg gatgtgttaa agctttgcag ctcactggga ttatctaagc aacagatgca
     3841 gcgtatgtat gtacaactgg agcatgtatc tttttcacag cagcttgtac tgtctcatgg
     3901 tgatcttcat ccggggaact atgcgctgag cggggaacgg cttatggtat tggattggga
     3961 gcatgctcat ctgaacacac cgctgtggga tgtatatcac ctgattgaca tgtcccatcc
     4021 gttgtttccc cgacgcatga cgtccgaatt gcgtattcgt atgttggaca catacgtgga
     4081 gcagctggag atgttgggga taagagtgga tcggacggca tttatgttgg aatatggcat
     4141 gtttgcggtg gtattttcgc tctggatgct gttgttaatc acaagtgatt tgcaaaggat
     4201 tggaacgaac ctgcatagaa acggcgacaa atggtcaaaa gagcaattag agtcccagtt
     4261 ggacgaaacg ttagcctgtt tgaaccaatg tgcagcattg atggattggg gacaagccca
     4321 accatgtaga tagtagctta agacatagac tgtatttagt tcgccaaaga aggtagggaa
     4381 tatatccatg aaaaaagtcg gtttggtcat gagaaaaata caatttgctg aagcgcaggg
     4441 tcctcgtatt tttgcagagc gtctgaagca gattggggcg gaattgggcg tagatattgt
     4501 atttgtatca ccggagcgtc atgtgagcag ccatgactgg cttccgggtt atgagcatga
     4561 gaagggtgac ctggttaatt atgatatcgt actggaccaa ctccatgagc agcagattga
     4621 gcacgttatt tatacggtat ccggctttac ctatttgaac ttgtttttta aaaacagcgt
     4681 gctttttccg catagtttcc ctgatccggc gcttacaggc tatgagatga tgaagccttt
     4741 ttatcagatc gtggacaagg ctatcgtaca gactgccttt ctcaagcagg agatggcttc
     4801 gaagtttggc gtaaccgatg tgacagtcat cccgatcgga tttaatgagc ggctggtgga
     4861 agagcatttt gatccctcgc aagtggtaga gaaccgggtg atgtggattg gtagagatga
     4921 ggagaaccga cgtccagatt tggtgctgga gtatgcgagg cataatcctg acaaggatgt
     4981 ctatatggta tttggcggtg aacgctacaa ggaaagtatg aagaagtacg agatcccggg
     5041 caatgttaaa cttcaatttg cgttgacgca agatgaggtg tttgcactga tgaacacggc
     5101 gaaggtgtat tggagctgct ccaaattcga tacattcgcc atgccgctga ccgaagcgct
     5161 cgctatgggt aaaatcgtcg tgaagccaga gcatccgtgc tatggacata tcagctctac
     5221 gcattctttt tcaggaaatg agaaaaactg gtttgagctg gtcaatatgg ctgccgcctc
     5281 accgcgtcgg gtttctacag aaaatcaggc atacgccatg gaacagtttt caagtcaggt
     5341 gatgaagcag gggtatcggg aattttttga tcactggtta agctgaacgg cgaggcaaaa
     5401 tactggggtt gcaactcgcg tctgagtatt cagagtgaaa ataaaaataa cccgcaaggg
     5461 ggtcactttt ttcaaaatgt ccatcttgtg ggttacggtt ctttgactta tcgtttggac
     5521 tttactggaa ccggggttcc ttttttaaat cgagtcggtc ttctcggaat tctgcgaatg
     5581 ccagaatccg ccgattctat gactgtatct ccgctatcgc ttcaggatga gccgccttgc
     5641 gatccacaat gtagctaact aacatgagta gcagaccgcc gacagtgata agtgatgcaa
     5701 cccatggaat agcggctagc cccatttgat taatcacgac gcccccgata aaagcgccgc
     5761 ctgcgttgcc tagattcaat gcggagtggc tggaggtaga ggcaagcaaa ggagcctcat
     5821 aggccagatt catgatgcga acctgaatac cgggcatgat gccgaacgca gcaatgcccc
     5881 agataaagac agtgataacc gccagtacct tgttttgaag cgtaaacgtc agaatggcca
     5941 aaataatagc cagtacagca tagtttgcga tcagggatgg tagcagtttc caatccgcaa
     6001 gcttgccgcc aacgatgttg ccgatcgtta cccctaggcc aaacaggacg agaatccagg
     6061 taatgctatg ctcggcaaag ccactaatat ccgtaagcaa aggcgtaatg tacgtaaaga
     6121 cagtgaacag actgccacaa ccgactgcac cggtgagcaa catcagcagc acttttggat
     6181 taaacaggct tttgacttct tgtttgagac tggaaggctt gtcctgatga atcaccggaa
     6241 tataacgaat gataccgaag agagaaatca agccgatgac cacaatggct ccaaaggaag
     6301 cgcgccagcc gagctgttgt ccgataaagg tgccaaaggg aacgcctata atgttcgcta
     6361 cggtcaaacc ggtcagcacc atagaaatag cacccgcgcg tttgtcagga cgaaccagtc
     6421 gggcagcgat cagggagccg gctcccaaaa aggttccgtg cgataatgca gtagccatac
     6481 gggccgcaat cagaaactcg taattgggag caatgacgga aaaaagattg cctaaaatga
     6541 atatgatcat tagcagacat agcagctttt tctgcggtac cttatgggtc aatacagtaa
     6601 gcacaggtgc gccaatggcc acaccaagtg cgtaactggt aattaactgc ccggcttgag
     6661 gaattgtaac atgaagatca tgggctacat tgggcagaag tcccataatg acgaattcgg
     6721 tcatgccaat ggcgaaggca ccaagggtca accatagcaa ggaggggggg aagcgatttg
     6781 ctgtcatatt ttcttgagta ctcataagtt tcttgtatcc tcctgaaaaa atagtaatgc
     6841 gagtatatca ttacaggcga tatctggcga cccattttgc aagaatttca catactaagt
     6901 tgatgagttt tatgtaattt acaaaagcga caggtaggaa ggagccaagt atgttatttt
     6961 ggtagtatga tatgaagatg taaataacac tgtaagaaac aatccaagga ggatacaacg
     7021 atggcaccta aagtggtaca tagtattaca gatttaatag gagatacacc ttgtgtaaga
     7081 ctccaacggc tcacagggcc gcaggatgcg gaagtgtatg tgaagctgga gtattttaat
     7141 ccaagcggca gtgttaagga tcgggcggcg ggcaatctga ttgccgaggc ggaaaaggcg
     7201 gggcatctca agccgggagg caccattatt gagccaacca gtggcaacac agggattggg
     7261 cttgcgatga atgcggcagc ccgaggttac cgcgcgattt tggtcatgcc ttcgaatatg
     7321 acgaaggaaa ggatcaatat tttaaaagcc tacggggctg aggtcgtact gacaccagcg
     7381 gaagaacgga tgccaggagc gattcgcaag gcaatcgaac tgggggcaga aattgaaggg
     7441 agctttatcc cgcatcaatt tgaaaatgag gcaaatcccg atatccaccg tacgacgaca
     7501 gcactggaaa ttttggaaca gacagaaggg aagctggatg tgttcgtcgc ctcttcggga
     7561 acgggcggta ccattacggg aacaggtgaa gtgctgcgtc agcatttgcc ggatctgcgg
     7621 attgttgtag ttgagccgaa gggctcgcca gtgctatctg gaggaaaacc cggtccacat
     7681 aagctggttg gcaccagccc aggctttgtt cccactgtac tgaatacgga agtgtatgat
     7741 gaaatcgtgc aggtttccga tgaggatgcg attacaatga cccgagcgat tgctgcccag
     7801 gaagggattc tggttggccc ctctagcgga gctacgatat ggacggcgat tcaggaagct
     7861 cggcgtttgg gagcaggtaa acgggtactt tgcattgccc cggataccgg agagcgatat
     7921 ctgagcatgg ggatattcgg ataaaaagat gtggaatgaa ggcaaaaaga ttcgactcat
     7981 ttatatgtaa gatccagcct cattaaggga agtaacaaaa gtgattggcg atatggcaat
     8041 caagaatata caagtataac aggatgactc ctgaagcgcc tacttcttca ctagcctatt
     8101 agctcgacct tgaaatatta tctttgaaag aataaaggat gatgggagcg atatagtaga
     8161 ttctttttca atggaagaac atagacattg aatacatcct tgtcataatt tataggttaa
     8221 tttcactcct gacaattaat aagccacaat ccataaggtt gtggcttatt aattgtcgat
     8281 tatagcttat attcgtgaga atttaaaaag tcttacggtt catattccgt ttttcgatct
     8341 tatttgtctc ttcagcctag cgatcattta tatgatgttg aagacccata agccttacat
     8401 tggaggcggg tcagagggat attactgcgc aacagtagag gcggtaaccg aagaaatgaa
     8461 aaactatatt gtcaatcaat tcacagagga aaagaacgaa agtttcagaa ttgagaacga
     8521 gttttagtcg gagttccagt acgattgtgc atatagagtt tcaaaagaac ttgaatctta
     8581 cgttacgact ttagtcgtcg acatttgtct aaatctacat gctttgagca ggtgcctttt
     8641 atcaatgact gcaatttagg aggtttggaa tacctttcag gaataaagta taaaaaacgg
     8701 gagaattaga tatattcttt attcatcgac agcaagatat gacatacggt cactcacaat
     8761 aaacgtgatt taggggtacc actgaaatca tgtttattag aatttaattc agagaggaag
     8821 aggaaaatga aagtagatca aatatttgac cttgatttaa gaaagagcta tgaggccagt
     8881 gagcttagcc cacaagcttc aatcatcaag acaaccatta aggtatccaa agcagtatgt
     8941 aaaactctta cctgtatctg taccggttct tgttccaatt gtaaataatt cataagcgat
     9001 tcgtaagtca ggggtagtga aatgcgctac ccctacttac attatggaga ttgcatgata
     9061 aaacctaata tatacaattg gcatgtagcc cggctgaccg atcattttag ttgtggtgca
     9121 actgttggtc agctgcttac tatcctgttt attgatacag gcgtcgataa atcccactca
     9181 gagatccaag gtaatttagt tgaggcagaa tgcaagtcat ttgtacctta tgagccttgt
     9241 ctaagcgatt acgttgggca tggtacacaa atggttagct ctgttaccgg caaatatata
     9301 ttgaagggga tatgcccttt cgctcgggtt gttgtctaca aaattacgga caaaaaagga
     9361 ataagcaagc ttgaatggtt gtatagagca ctggaagagg gtattgctaa aggatatccg
     9421 attatcaaca tcagctatcg tacagaatat gaggtcgact tattcgagtt caatcggttt
     9481 caggctttgg ttgactgcgc caatgcgcaa ggcatctggg tagtctgttc cgcaggaaac
     9541 gatggacgcg atattacgca ggagtacaga gtgcctgcga atttaaaggg agtataccca
     9601 attggatcaa ctaataagaa cggggatatc tccgggttca gcaatacgct cagcggccaa
     9661 ttttttgcgc cgagtggtga tgagtatgaa atcaattaca acaatgattg ggtaatggtt
     9721 gccaaatcaa gcttcgacac agaggattat ttatacaaag tgctgggatt tgacaaagca
     9781 tacacagtag gtatcggtac gagtattgcc agcgccttat tcagcggagt tgttgcctct
     9841 cttagcggag agcttatcgc gcaggggatg aatgccgggc gcacagaaat ggagtgtctg
     9901 ctccgtcaag gcgcgagact gattgatgtt cagcggaatt attatgaagt aagccttgcc
     9961 ggttcaattc gtgctttaag acagatgaga ggttgattgc atgttggaaa actttgaaat
    10021 ctcggaaaat tacatgtacc ggaagacgtt gcttggcatg gagtattata cgcggatatt
    10081 tgatcatgaa caactagatg atgatgaata tcttgacaaa cttgtacggt tcgttcagca
    10141 gcaggggttg atggattcca tttatgtctc cagcccctcg acctacgctg cactgcaaag
    10201 cctggaacaa ggcagagcat tgaagtccaa aaaaaagcgg aatcttatcc tcagtctaag
    10261 caagttcatt tctcgggcaa tttgtagacc aacaccgttt ggactgttcg cgggagtagg
    10321 catttcccga tttggaaaca cgggaggcgc tggagaacat gtcgtctggg caactccgga
    10381 ttatagccta atttaccgct taatagggct tttccatggg gatgcggatg tccgcaatga
    10441 attgagactg agtgtaaata acacctctta cattgaccat cacaggctcg tcatctctta
    10501 tcagactctg tttgcagcag atcaagagga acgaagcact gaaaatatat ctattctcaa
    10561 aactccggtc atagatttca tcatgaagat ccttgataaa gagcaacaga cttttctgca
    10621 gcttatgcaa gctataaaag atgccttcgg cgtggatgac acgatcagca cagatttttt
    10681 gcagcaattg atagaacaag gctttttggt gagtgagatg attcccaatc ctcgggatag
    10741 cgcacctctg gagcatctga tccgtacact aaagctgctt gctgctccca aggcagcata
    10801 ttacgcagat attttggaga gagttggaca tgccattcag gacatcacaa ttgctgagga
    10861 caaacgtgaa ggcattgagg ctgtccgaaa actagtccag ctcatacttc ccgattatca
    10921 gggcgacttg gtcaaaatag acgtaaggct gaatgaagca aatgaaattc acttatcgga
    10981 cagcgatagg caagcgttgg cccaagtagc ttcaatattg agcatgcttt ctacgtacag
    11041 gaaagaggat acactttccg actatcgtca gcaatttact gagaagtacg gagtatatga
    11101 agaagttccc ttattgcagt tgttcagtaa gacgttgggg ctcggcaaac ctgaagagta
    11161 caagagccac taccagaacg gagataagta caggcataag gatgaaggca ggttccgaca
    11221 gctcaaggcg ctaattgcgg agtggcagac tgaagcgctt gccaatcatt cggatatcgt
    11281 gcttgacgag gccaaaatcc aacagctgtc tgaattgagt ctggagaatg tctatgtctc
    11341 gttcgatttg tattattcct gcatggagaa tgagcaaggt gaagttacgt tttatttaaa
    11401 caacagagcc ggatcattgg aagcgtgtca gagcttcgga agatttgcct acatgtttga
    11461 caaggatagc cgtgatgaaa tcttccgttt tgtcaggaac ccgaaggatc agaaagcagg
    11521 ggagagcgcc gctgaaatct cattttaccc attcagcccc aaaataacta atattatgac
    11581 ggcaggccca acaccggatc aatccatgga tatggccacg ttccccaaga atcggaattt
    11641 ggacatttcc caactactgg taggagtgga ggattcggga tacttttatc tgaagcacag
    11701 ggaaacagga gaactggtat ttcccaaact aagcagcatg tacaatacag agctggcgcc
    11761 ttatctgatc cggtttctga atgatattaa tctacagtat cagactggat ggtcccatct
    11821 ggaggagtat ctctatgatt cttcttttac accaagagta acctataaaa atatcatcat
    11881 ctgccctaaa aaatggacat tatatgcgga taaacggttc cagagcgaag aacagttttt
    11941 ggcctttctg gaggattgga tcataaagta taacattccg cgatatgtat atttggtgga
    12001 gctggacaat aagctgttgc tggatttgga tcgccatcat catcgaaagc ttttgcacaa
    12061 agaatatacc cggaatccgg aaggcaaggc ggctgttatt atggagacgg agaaagaact
    12121 gttcgcttcc gttaaccggt atatggagga gtgcgtattt ttttgcaaaa gcccgatgtt
    12181 tcagtacttg ccgatagaca gattgtctgc acaggctacc gataaaagct taaataaagt
    12241 gctgagttct tcggtgaatg ccgtttatta tccaggttcg gattggatat ccctgcaggt
    12301 gtattacaat caggaactgc taaccgattt gctgggcagt gcatttaaga cattcatgga
    12361 caatagcgcc gagtacttca ttgatcaggt attttttgtc cagtatgcag ataaggagcc
    12421 gcatatcagg ctaaggtgca aaatgtcggg aagcgtgcag catcagcgtt tcacggcctt
    12481 gaactatgtt tttgatttcc tgaatactgt aacctcgtcc ggattggtta gttcctattc
    12541 ggttgttcct taccggcctg aaattttgcg gtatggcggc gcagccttta ttgaacaagc
    12601 ggagaggtta tttgctatcg attcttatct agtttcaggc tattatgcag gcaagaggtc
    12661 aattaatgga accgatcaga tgttattttg ctgcaccgga ctttttgagg ttgtgaactg
    12721 cgcgtatccg ctggcagaag atcaattgaa ggctatggct gcgattattg atccgaagaa
    12781 attcaggcag gagtatcggg aacacaaaga agcgctattc caaaggattc aacagacccg
    12841 ttccatatcc ttgccagcaa gcgataaaga cgacaggttg cggcaatacg ctgcatattt
    12901 caccgctatc cgggaagctg acgacagaac caattactac gatgatatta tgtttagcat
    12961 catgcacatg ttctgcaaca gagtgttcgg cctggaccgg gaaaaagaag agcttgccct
    13021 acacctgtgc tactacagtt tggaagatta tttacaggta agcaaatatc atgttgccta
    13081 ttgaggagga gtttatggcg gtcaaacaag tcccgggaaa tttatctgaa atagtcaggc
    13141 aaagcgcaga aatttacaaa gatatagata ctgtaaccct gctaatcaag aagcacgcca
    13201 tgcatgatta ccctgaaatg gagctgatat cgctggcttc aggatacccc ggaatcagcc
    13261 ttcttctgga taaactagat gaagtttacc cgggggaagg gtgggctgcg cttgctttca
    13321 agtacaatca ggagattgtg cgtttaatcg gtaatatacc gttccattca ttatcactgt
    13381 ataccggatt agcaggcatt atttatctgt tcaacgagtg ttcaagaggt tcaacaagat
    13441 atacgaatgt gctctcgcag acgctggata tgtttcttag cagctacgag gaattctatg
    13501 aggagacaag ggggaaattg gaagactctt tgattgagga tagcgacttg gatttgattt
    13561 caggctggac ggggattgct gctgcattaa tggaggttaa ggaacgccac gacagatacg
    13621 ctgggaagct ggatgcggtg ctccttaaga tacttcaact gattacggat gctgtaggca
    13681 agctgagata tttcgagcaa cttcccgaac agactattta ttataatctt ggcatggcgc
    13741 acggaattac aggagccatt aatctgctag ccgttgcaca tctccgccgc tacccgttaa
    13801 ccggattgag agaagtactg gaagttgcca aggcttttct actcggaagt atcagggagt
    13861 ggaacggcac ccttgtcata cctaatatgt tcacaccgga tgaatccgca gggactagtc
    13921 tgaatccagg ttatcacaga gatgcatggt gttacggcac accgggagct tctgtggcta
    13981 tgttccggct gggattggcc ctggaggaca aagcgctgca gcagcaggct ctgcaattgt
    14041 tcaataccgt ttactctaga ccagattcac taagaaaggt aatttcaccg acgatctgtc
    14101 acggctatgc aggcttggtc ctgattcagc actatttcag ccgtgcggcg gccatgccgt
    14161 ttaaggatga atttttgcat cgtttgttat catatcgaaa tattggtgag ggagtacctt
    14221 ttatagacct tgagggaagc gtcgatgatc cgttatctct cgataaagtt gggctgctcg
    14281 atggatgtgc aggtgtattg ctgacactgc tgacctgtga taatgagaac ttgagtacat
    14341 ggaagcagat gctggtattt agctaacagg aggagacggt aatgttcatt ttattaaaag
    14401 aaattattac agtcatggtg ggattgatta ccgattttct ctcttttcaa ctggatgcat
    14461 atttttatat ttggtttctg gtcctgttta tttcaagctt ggcagcgacc ctggttcaac
    14521 gaagcgaagg gactattacc tacagcaaag ccgaatgtgt cggaatcaat gtgctagttg
    14581 tcgtattata cctagtaatc ggtacaattt tggccagata ctttgcaagt tttgaggatc
    14641 agcagattgt tgctgaagat aagattatgc tgtataaaat ttcttttatg cttacatccg
    14701 ctgtaattat tgtggatatt atacttgata ggttgaagag agggcggaaa ttctcctact
    14761 ctttggagtt tcttgccgga agcgccgtgt gcttcttact gttccagtta agtaatcaaa
    14821 cggactggat aggaaccaag ctgtcgctct cctatattgt catggtagcg atagccgcag
    14881 gtgtctatac aatggcaatg aagtttttgc tagaatacga aaatcacaaa gagaaatagg
    14941 tgattaagcc ataatggaat tgaatatgga gagcacggca tataaaaaga tcggtgaaga
    15001 acaacaaacg gctcattcct tactggagtt aaccaaaatt gcgagatggc ccaagtttgc
    15061 gcttgcttgg agcatcatat ttacactgat ttccgccgct ttttcattag tattgccgat
    15121 cattacaggc aagcttgtcg ataagatctc agctatggag ctgacgatcc agaccgcagc
    15181 tgtgcttatt tcgctgtttc tggccggagg gattttaaac gccgtgtctt ctctgctcct
    15241 cagatatgtg gggagcaagt tttttcagga gctgcgcctg aaaatttggg aaaaaattat
    15301 ccatttgccg gttaattatt ttgataacaa cgagaacggc aaaatcatca gcagaatgac
    15361 gaacgacctt gctattgtaa gtaatttttt ggctatcact ctgccttcta ttctggctga
    15421 tgtcctgatg gtcactggtt gcatcatcat gttatttgtg ttggattgga gattaatgag
    15481 tgtactcgtt gctctgattc ctataacggc gctactgatc tatcccattg gaagaaggat
    15541 gaataaggta gcggttgagg cacaggatgc agccgcagat ttttccggtg agttagccaa
    15601 aattctctat aacatcagat tcattaaagc gacgacgtcg gaacagcttg aaatgaaata
    15661 tactcgagag atacttggac gtatctttcg cttgaacatc aaagagggaa tattgtcagc
    15721 tgtcattgag ccgattgtca caattgtcat catgctagct ttggtaggaa tgttttggta
    15781 tggaagcgcc ggcattgccg ctgggcatat cactacaggt gctctggtat ccatgatctt
    15841 ttatttgttt acaatggttt cgcctctgac ccagctcagc agttttttct cgcagtatca
    15901 gaaggccaag ggagcaagca aggaaattca taccatatat aaccagcagg atgagaagca
    15961 agaagaatta ggcaatgtgc cggacatgaa aagtcatgat cagaattcgg atatcctgca
    16021 ttttgccaat gtttctttct cgtacaacca gggccaaccg gtattatcca acgtggagtt
    16081 agccttcaga ggctgtacca ctacagcgat cgtagggcct tccggctcgg gaaaaacaac
    16141 aatattttct ttaatagaga aattttactc agaatataat ggaaaaatat attacaataa
    16201 tgtatatttg gataagatta ggacggaaga atggcgtcgc aaaatatcct atgttatgca
    16261 agatagtgac ttactggtag gatctgtgag agacaatctg gtatatggcc taaacagaga
    16321 cgcggatgac catgagattt atgcggctct tgatacagta ggcttgaagg aggtaattca
    16381 tcaattaccg gatggtttgg atacctttgt tggagaaagg ggagtcaaat tatcgggggg
    16441 acagaagcag cgaatccaga ttgccagatg cttgctttca gaccatgaga ttctgctgtt
    16501 tgatgaagct accgccaacc tggatagcga gtcagagcag cttgtccatg atgtaatcaa
    16561 gcttctctcc aagaataaaa tgaccattgt tatcgctcat cgtttgtcaa ccatctacaa
    16621 agccgaccag attatctttt tggataaagg agaagtaacg ggggtaggca cgcatcacga
    16681 attaatgagc tggcatgata aatatcgtga ttatgttcaa ttccagcttc ccgcacaatt
    16741 aagttaggga ggggcggtgg cgttgtatca tcaattgtca acgtggatcg ttgataaata
    16801 ctttcaagac gaagaattgg aagcggagaa gcgtgcttat gtgctttatt atctggagaa
    16861 catactagct ggtacagaaa aaatacttct tgtattggtc agtgcctgtt tgctcagtgt
    16921 attagccgaa acggctgcga ttctgctttc ctatacagtg gtccggcgaa agtcttttgg
    16981 ctggcatgct cgcaagtcgc atcattgcac ctgggtcagt ctactgacct ttgtgtttgt
    17041 tccctggctc ttaaaggaag tagaatggaa ccgcattttt ttggcgacgc tctgtctgct
    17101 ttctatcatt ctgattgcca gatacgctcc ggccgatacg gaatgcaatc cattggtgga
    17161 tccgaagttc agaagagcat gcagattaca agctatcttt ttaagtatag tgtttgtttt
    17221 cgtggccatc gcactagatt tttatccttg gttaatattc gggctgtttc ttgaagcagt
    17281 tgtcatcaca ccagtattct attccataat gagaaggagt tatgccaatt atgaacaata
    17341 tcaagaatat taaagaacac agaaacaacc atacccagag actcaaggct aagctactgg
    17401 agcatatgag taaaagaggt gaaggaggag gggtttgttt cgggttgttc tatgaaccag
    17461 tcaatccaaa agttcggaaa ttgatcaaaa aatgattaca tccggcattt attttttgca
    17521 atacaccagc tatcttgtaa tatatcatat ggtcagcggc aatggtctaa gcgttttccg
    17581 tatgaattat aagttgctgc tgtttttggt catgtattat tttatcggaa taacagctct
    17641 ggataacttc ggactgattg tttacctgtt tctatttgtg ctactagcat tatacgggtg
    17701 gttgaccgac aaatgtgaat ccttatgggt cataggcttc tacgccatcc ttaccatctt
    17761 tattacgaca ctgctgggtt atttcataac ggtgatcagc tatgcggttc cttatgaata
    17821 taaaaacaaa tggacggcgc ccttcctaac cgcttgttca cctccgctga tctacttggc
    17881 gctccgaaag cttgtgtctt atttgtttcc tactccggcg gtcaggcttt tgaagctata
    17941 tcggattaag cttatcgtcg gggcttcttt aatcttggcc ttggggatca tcggactcgg
    18001 actcattatc tattcggagt gtgaaagcaa caatccgtat ccaagcagat taaagattgt
    18061 gttgatgctg atcggcttga cctccatatt cctgatgacg atcaattggc tgtatcgctt
    18121 cctgcgtgaa cgtgagctag agaagaacaa gaccgaacaa tacctgcagc tggaggctta
    18181 tattatggag attgaaaaaa tgtacgaaga cattcgcggc ttcagacatg actataccaa
    18241 tatcctgtta atgctggacg aggggatcag aactggggat ttggcaatga tcaggcggat
    18301 atatgagagt tctatccaac ctactgcttc acagttgaac ggatattcct atagtctgga
    18361 taacctgatt aatctggatg taagtgagct caagagtatt attacatcca agatgctggt
    18421 ggcaaagaag cgtggagttg acgtaaaact ggaaattgag agcggtatca gtgaaatgta
    18481 tatggatatt atagaccttt gcagagtaat ctcttgtttt ctggacaatg caatcgatgc
    18541 ggcactagag acctgcaatc cgtccataac tattgtgctg atccatgaag acgatattca
    18601 gacggtgacg atacgaaact cttataatca gtctgcactt gacgggatta aggtgaatga
    18661 tctctacaaa cgaaactttt caacgaaagc ggacaatcgg ggtcttggct tgtacaatat
    18721 agcaaaggtg ctgcgcagca acaagtatgt cactttggat accaaaaagg aaccggattt
    18781 tttcacgcaa acattaatta taaagagagc gacatcatga atatttttat cctggaagat
    18841 cagtttatcc agcagcgcat aatggaaaag atggtccgta aaagctgcga ggaacttggc
    18901 atctgctgca gcaatctcat tatcaccagt aagccggatc tcctgctttt tgaatcaaaa
    18961 gcttgtgcga ataacttgta tttccttgat attgaaatct cgggttgcca gatgaaggga
    19021 ctggaagttg cccaggaaat cagaaaatat gatatgtatg ggcatattgt ctttgttact
    19081 acccacgatc atctgtctcc gcttaccttc caatacaagg tagcagctct tgatttcatt
    19141 atcaaggatg ctactcagga tgaaatggaa aaaaaggtca gagaagttct tgctgttgcc
    19201 catcaaagaa agcctgtgtt ggatgtcaac gattggttta tactcgacaa taaatttacg
    19261 aaatttcaaa tttccttctc cagcatttat tactttgaaa caaccggtgt tccccacaaa
    19321 atccgtctgg tttccgaaaa cagaactctt gagttttacg gcgacctgaa agatattgag
    19381 gctaaggacc caaggttgtt ccggtgtcat cgggcattta ttgtaaacct gatgaaggtg
    19441 gaatctatag ataagagcaa gaaagagatc atttttcaaa ccaatcagaa ttccggagaa
    19501 gcaaggcgca ttattcccgt ttcccgccaa ttgttgaagc acctcctaga taagatggga
    19561 gaccggagcc tcctgaatag acctgtttac gaatagaata gatacggagg gcatagtcct
    19621 tcgggaagaa aaggggagga atatggaaca aaggttatcc gttcaagcag aggtgaaagg
    19681 cattgatgcc accagtttaa aattaattgc aatattggca atgctaattg atcatattgg
    19741 agggctattt tttgccgatt ttttgggctt tcaggtggta ggcagaatta cattgcctat
    19801 catggctttt tttgtagccg aaggatatat ccataccaga agctttaaaa aatatacaat
    19861 gcgccttgct gtaaccgggc tggccagtgt ggtgccttat ggattggtat ttaaagattg
    19921 gtatagttcg ggaaacatca tgctaacgtt gttgatgggc ctactggcaa tatggttcta
    19981 tgacaacacg accaatcctg tacttaaata cttggcgatt tcggctcttt gcgtagtctc
    20041 ttttttggga gactggagtg taattggagt gttactggtt ctagcttttt atgtggctcg
    20101 caaacaacag aagatttaca acgggtggat tattgcaata attgcgctta tgttcatttt
    20161 cggagtcatc attatatggg ctgttcccga ttcgctcagc atcctgggca tcaacgccag
    20221 cacaatgaac gaatatcttt atccgtttgc gatcggcggg gcctgtattt ttgccctccc
    20281 tctgctatcc cgatataatg gagagagggg aaaaggctca cgaaccttct tctatttgtt
    20341 ttatccgctg catttgctcg cgctctatct gctgaagttg gctattgatt attacatata
    20401 agaagggctg tctaattttt gcggtttcac aaactattcg aatgttgatg aagtaaggaa
    20461 aacgttgagg gttgaaggag gagcagcatg aagattatgc ctttacaaaa acgtggaatc
    20521 tccgatagtc ggctggtgct cggttgcatg ccttttggtg gagaatggag ccatgcaccg
    20581 tttacacagg agcatgtcct tgaagcagaa agagctgtag aagctgcacg atccatcggg
    20641 attacgatgt tcgatcatgc agatatctat cgtatgggga aagcggaaga gattttcggc
    20701 cggattttaa agggacagcc gggcttacgt gaacaaatcg taattcagtc taaatgtggc
    20761 atttttctgc cggatggtac gctcccgggc cgttttgatt tctcatatgc tcatattatg
    20821 gagtccgtgg atggtatcct gaagcgcctg ggtacggaat atttggacat cctgctgctg
    20881 catcgccccg atccgctggt agagccggaa gaagtagcga aggcgttcag tgagcttaca
    20941 gcatccggca aagtaaggca ttttggcgtt tccaatatga atgtaagcca aattcggttt
    21001 ctggagcgta gcctgacgga gccgctgatc actaatcagc tggagatgag cctggcccat
    21061 ctgcattttg tagatcagac cgtacatgtg aaccagcagg cggggacgaa tgtacatttt
    21121 ggcgaaggtt tgctggaata ttgccaaacc gaggatattc agctccaagc ctggggaccg
    21181 ctggcgcagg gacgttttag cggaggttct ttagaagggg agcctgagca tgtcgttaag
    21241 acggcagagc tggtgcaaaa gctggcttct gaaaaggaaa cgacacgtga agcgatcgtt
    21301 cttggctggc ttatgaagca tccggcacgg attcagcctg tcattggcag cgccaatcct
    21361 gaacgaatca aggcatctca ggatgcggag cgccagagcg agctgatgac ccgtgaggaa
    21421 tggtatgaat tgtatgtcag tgcgcgcgga caagccttgc cgtaactcgt actgcgaacc
    21481 tgtttgttac agcaggcgta tgtggatgta agtgtataac cttgtttata cgaactgtag
    21541 tttaataagg ccctcccttc gtctcattaa cagacggagg aagggcctat ttacatggat
    21601 gtatctcata ttgcctcagt agctattcct cttcgtagcg tgcaagggcc ttggcggttg
    21661 tttccttcat tcgtgagatc agccgtgagc cttggatgac cttgacacgt ttgccgagga
    21721 aacggatttt ggatagcaca tattcacatt cgtctgcctg gaaggtgagt gtaatacgat
    21781 aggtatctgc ttcctgaaca tattcgacct ctttttcaaa gcaggaaaaa gcatataata
    21841 tacgggacat ttcaccgttg tatacaggaa taatttcgat gatgccctgt tctttgcgcg
    21901 actccagtat accgagtata cgttgggaga atttttcggc ctcttcgcgt agaagcacgt
    21961 tttccgtgat gttcacgata ttagacagct tggtagacat gagcgcgcgg tgtctgcggt
    22021 tataccacag taggctccat tcttttttga ccatggagaa ctccagctta tatggaaaac
    22081 cggacattcg ctcatgcatg cgtccgttgc gcagtttgta ggttatacag atgcctgaac
    22141 gggatcgcag aatgggacgc aattcacgca agagtgggtg ataaatcgaa gcagcaggaa
    22201 cccctgcctt ttcgcgtagg ctgccatcgg cctccaaagg ttcgtcgtct gcaagtaatt
    22261 gccgaagctt atccagtgta gacggggtaa aagcctctgt tgctgccgag tctgcaagca
    22321 tagatttgag ccaaattctt tcctgtgagg tggtagcaaa agcgcccgat tcatccagcc
    22381 gtgagacgat ctgatagtta aatattttct cgaacaggct cataataggc ttgcagctcc
    22441 ttccattcct gtctgaattc cttacgcagc cgctggggct ccaatacctc acagcttgat
    22501 ccgaagctgc gaatccacgg tttaatctca gtgattccat tcactgtgat ttcatagata
    22561 aaggattcac tttcttcctc cgcaatcgta ccccactgtc cctgtgacag cacacgttcc
    22621 cgaataaagt tgcgcttcgc accctcagga ttaaaaaaac gtacccgtac cttcacggga
    22681 cgacccgtat caacaagcca gctaaaccgc attttttctt ccaacacggc taacaggtcg
    22741 gcataaagct gctctgggac aggcttgccc tccaccattt gagtcatgcc ctccatacga
    22801 aacttcatga ttcctttgcc gcccacatga ccaagcacgt accaacgtcc atattgatga
    22861 tcatagatga cttgcagggg cagaatggta tgttcacggc cttcagtctc tttttcaaat
    22921 agtgggtttg tgttccgtga cccgtacatg cttcgtttgg atgtcgaaaa atataaaaaa
    22981 gttacacagc ggcgttgccg aatggcatgc agaagcggat gaatatgggc ttcgtccaga
    23041 atgcgtgaat aataatggta tttatataaa aaaggctctg ccatctcgcg atctccgagc
    23101 tgacggcgca tagctttttt aagatgatct cgtaacagat atccctgcac agaggggagc
    23161 tgggtgttgg ccataatgtc cacaaaatca tataagtcca gtaattcctc gtccgtcagt
    23221 tctgtcacca gatcgttgcg gacagcatag cgatagggtc tgccaccagg ctccttgcga
    23281 accacgccga cttcaaccag atatttcaga tcggaacgaa tcgttttctc atctggcagt
    23341 gaactgtcgg aaggcaggcc attgcagcaa gcatccaata gttccatggt ggtcataggc
    23401 tgtgactgta gcgctgtcag cagaagggat aagcggacgc tttccgattc cttgagcgat
    23461 ttagcccgaa acaggaataa caataatgga tcagccgatt cgtaataatt aaagcgtagc
    23521 atctcattaa aatcatgtcc ctgttccgca ggcaactgct gttgtacgga ttggacgatt
    23581 tccttgagac gccggattgt tttatcaaag gtatgtaccg aaatgcccag tctatctgca
    23641 aattgctgcc gattataagc tccgcttgtt agtgtgagca tacgcaggaa ttgaatttct
    23701 ttatcaaaac tctctcttgc catgatgcat tccccgtttc tgtagccgtt ctccgaaaat
    23761 aagtatccct ttattctaac agggaaggga tgcaggaaaa agggaaatta ttcatctttg
    23821 taatactttc accatgttca cgacttccaa aataaagcat cataggagta taagatagca
    23881 cgatgaaata agaagcaata cataacagaa gggtgatgca acatgtttgg acgacgcaaa
    23941 aatgaagtgt tatatccatg ggtaggtaag ctttcgattt atgaaacgat taagcaggga
    24001 ctggaccctc agggcaggct tacggatgac catttaccgg atgatgaaga atactgggca
    24061 gggcacacga tgcgttgggt ggcaggagga ttggatggag catttgggca tcatggcgct
    24121 ggcggagatg gagagactaa caaaattaag gatctggcgc agttgttgtc cagacaatgc
    24181 cgcaagccag ggatgaagac gagacgtgag acgtatgtac gcttaatgga ggaaaatgca
    24241 ctcagcctga ttgatccgct gctagatgcg gtgcgcgagc atccagcaat tcagccggaa
    24301 cgattgtatg aggaagcgcg ttggctggct gaacacggag cacatcgcaa cgtggtgaag
    24361 gtcggtattg cgctgctcgg attgctggag acagagcagc atcacgagct tattttaacg
    24421 ctagccaagc atgatgaatt cacgctatat gcggctgtgg caatccgtaa tatttcggag
    24481 caggccaacg agcagttgta taggttagcc tcacaggtac atggttgggg acgtattcac
    24541 gtcgtagaac ggctggagcc tgcgcggcag gaaatacgtg actggttatt acgggaagga
    24601 ttccgcaaca atgtcatgta tgagtatctt gcttatgagt gcgctcataa aggtgagctg
    24661 catacagcca tggctgtacc gcacattgat caggagttgt ttgacggggc aggcgatatt
    24721 ctgtcggctt tgctggcagc aggcggaccg gcggaaagta tagacgatta tgagcatgcc
    24781 gctatggtca taggcaacta ccttcgtcat gctaaggcta tgtgtacgac tgtgaagcat
    24841 tttacgatca tcatggatat tgcagatttt ctgggtgaag aggacgattc atgggaggca
    24901 cgttatgagt atgaatggac gccggaattg cgtaaacgtt atgcgtcgat ttgccagcag
    24961 atgatgaacg atccgcagtg ggtgaagctg gtagagcagg aattgcagca tgcagattca
    25021 tcgcatctcc actgtgccat tcgcgtagct agaatgctag cactagatgt atggcctgtg
    25081 ctatttgatc aattaagcaa atacccagtc aagcctaatc tgtactttga actcatcaag
    25141 acagaggatg aacagcgtgc tcgtaagctg atggcttttg cagaaaagca cctgcctctg
    25201 ggagagattg cttccggtcc tgctgatgtg ccggggtttg gaccggagta tgaagcgcat
    25261 caatgtctgg gtatgctgtt gcaactattg gcttcttacg aaggaatggg acaagagcta
    25321 gttgctgccg gactttggag tccgttgacc tccaatcgcc gtgcagcgct tcatgtactc
    25381 aaggtatggc cttctgagat gtggggagag gagacgacag agcgccttcg ccgcttatcg
    25441 gtagccgaaa cggaggagtc gattagagaa cagattcggg aaatacttta atgataaggg
    25501 agggaacaac atgacagatg tgaagcatgg acagggtttg attcaaccgg acatgcgcga
    25561 aacgattttg cgtgagctgc gcgctttgga gcaggaggag caggtgcgca ttgtatacgc
    25621 ctgtgaatca ggcagtcggg catgggggtt tccttcacag gacagtgact atgatgtacg
    25681 atttatctat gtaagaccga tagaatggta tttgtccatt tttgataagc gggatgtaat
    25741 tgagcggcca atcagcgatt tgctggatat aaacggctgg gatttgaaaa aggcactcca
    25801 tttgtttcgc aagtctaatc cgcctttgct agaatggctg caatctccga ttccctattt
    25861 ggagcagtat tcagtagctg accagattcg tgcgatatcg ccgttaacct tctctccgaa
    25921 gtcttgtatg taccattatc tgaatatggc gcgggggaac tatcgggatt atttgcaagg
    25981 ggaacaggtg aagattaaaa agtattttta cgtgctgcgt ccactgctgg cctgtggctg
    26041 gattgaacgt tacaacagca tgcctccgat ggaattcgta gacttgctag aggaattcat
    26101 tccggccgat acagaacttt atcaggtgat cgggcatttg ctgcaacgta aaaaagcggg
    26161 tgaggaactg gatatggagc cacggctttc ggtggtgaat ggttttatac agcagcaaat
    26221 tgcttatttt gaacagaagg cgcccttgtt tcagcatatg gagagtggac gtgatcagca
    26281 gttggatgat ttattccgcg ctgcggtgaa tgaagtgtgg aaagcataag actggaaagg
    26341 agaagtggag tatgcacatc acgctaaaag caaccggaac ccatgcaggg atgatttcgc
    26401 atttgcttgc taagaatcct tacaatacgt atgatcgcac agaaaaaggc gcacgtgtac
    26461 gcatggtgta caccgttttt accgaggaag aggctgagat cgtcattcag gcttcgccag
    26521 attcgattga tttggtcaaa aacagtccag acagctatga cattacacaa tatattaatg
    26581 accgggagtt tgtaaccagc agcttatttt gcacttatgt tcgtggctcg cttggcacgg
    26641 ccctgaacgg caaacccaag gaagactatg caagatgggt gacgcaccct tttgcgctgg
    26701 agttatcgtt tgggcccgtt gcttcggatt tgccggattc tgtggtggag ggactatttg
    26761 ctccgctggg ctatcaagtg gctattgaac gaggggaagc ggactattct tttcagctga
    26821 aaaatcgaag caccgtcaga tatgtcacgt taagtggcca tcagacggtg cagtatgcgt
    26881 tgcgtcagtt attactgttg attccggtgt tggataacta taagcactac tacattagtg
    26941 aagaagagtt tgacaagctg ggacgttacg gtgaaggctg gctgccagag catccacttc
    27001 gcgagcttat cattcgacgc acgcttcgtt ttaccaatct gattgagcaa tttgagcaat
    27061 ctgattctgc taaaacaaca ggcacaaaaa aacatattga aaaggatact gtccaagctc
    27121 aaaaggataa gcacgaacag attcaacagc cagaacagcc acaggaggaa gggaagcaac
    27181 agcctacagt acggctaaat gagctgcgat atcaagccat tatggacgta attcgcaagc
    27241 tgcctcacag acagaaaatc gtagattttg gttcagggga agggaagctt tcggctcggc
    27301 tggctcgaat gacgggcgtt gaagagattt gggcggtcga gccgtctgcg tat
//
