LOCUS       NZ_CP117876            22484 bp    DNA     circular CON 26-MAR-2024
DEFINITION  Paenibacillus sp. KACC 21273 chromosome, complete genome.
ACCESSION   NZ_CP117876
VERSION     NZ_CP117876.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus sp. KACC 21273
  ORGANISM  Paenibacillus sp. KACC 21273
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5354372)
  AUTHORS   Kim,S., Heo,J. and Kwon,S.-W.
  TITLE     Genome sequence of Paenibacillus sp. KACC 21273
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5354372)
  AUTHORS   Kim,S., Heo,J. and Kwon,S.-W.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-2023) Agricultural Microbiology Division, National
            Institute of Agricultural Sciences, Rural Development
            Administration, 166, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun,
            Jeollabuk-do 55365, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HiFiasm v. 0.16.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 186.1x
            Sequencing Technology             :: PacBio Sequel; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028736095.1-RS_2024_03_26
            Annotation Date                   :: 03/26/2024 01:21:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,697
            CDSs (total)                      :: 4,591
            Genes (coding)                    :: 4,576
            CDSs (with protein)               :: 4,576
            Genes (RNA)                       :: 106
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 15
            CDSs (without protein)            :: 15
            Pseudo Genes (ambiguous residues) :: 0 of 15
            Pseudo Genes (frameshifted)       :: 3 of 15
            Pseudo Genes (incomplete)         :: 11 of 15
            Pseudo Genes (internal stop)      :: 1 of 15
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:56:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4635872
            Orig. end                         :: 4658356
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117876.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Korean Agricultural Culture
            Collection (KACC).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22484
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="10"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22484
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22484
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12484](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12484)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(1046..1060)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     misc_feature    1222..1233
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.11"
                     /tool="antismash"
     gene            1380..1826
                     /locus_tag="PQ460_RS20310"
                     /old_locus_tag="PQ460_20310"
     CDS             1380..1826
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019424552.1"
                     /locus_tag="PQ460_RS20310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20310"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_337994014.1"
                     /transl_table=11
                     /translation="MPTVIRQATTADVEALITIMNEYIGDFYQKPKPPVEKLHHLITTL
                     LDLQLGVQFVVEQNDQTVGFATLYFSFSSIKADKVTIMNDLYLQEHLRDTEVEVQLFKH
                     CQTYTQDHGFAHMSWVAAPHNTRAHRFFDRMGCTRVDWVDYMIV"
     gene            complement(1932..2957)
                     /locus_tag="PQ460_RS20315"
                     /old_locus_tag="PQ460_20315"
     CDS             complement(1932..2957)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017814586.1"
                     /locus_tag="PQ460_RS20315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20315"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_274170972.1"
                     /transl_table=11
                     /translation="MAKMTMADVAREAGVSKSTVSQYLNGRYEYMSSNTKDKIAAAIQA
                     LDYRPNVLARSLKQKRTFTIGVIVANMLHQFSLEICRGIESYCREQGISVILCNTDEDE
                     AREREDLELLRSKQVDGVIAFPSGQLTPLYQKLVQEGFPLVFVDRKLEGVQVSRVVVDN
                     EQAAYKATEHLIHTGHQHIAMLTAPLSISTRVERVHGYTRAMEELLPQITPMILSDEVK
                     QLRHTLSIWAQQQQLPTAIIAGNDLVLLEVLAFLKEYQLQIPQDMALIVFDNIPFAELL
                     TPTLSTIVQPSHDMGRQAAEMLLASISAQSTQQEQPAIQEKQFTCTLMIRESSAQPLNI
                     Q"
     gene            3158..3616
                     /locus_tag="PQ460_RS20320"
                     /old_locus_tag="PQ460_20320"
     CDS             3158..3616
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277997.1"
                     /locus_tag="PQ460_RS20320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20320"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_274170973.1"
                     /transl_table=11
                     /translation="MRNDNSNLPKTIDYTAECACLNFRKASRFITSLYDEYLRPVGLRA
                     TQLSLLMALEQAGSVTITTLAELLLMDRTTLPRDLKPLERNGWVSITPGEDRRKRFIAL
                     TPDGQHLLNTALPLWEQAQVRVQEYMGEDRYRGLLGQLSDIVKLNRQN"
     gene            3682..5010
                     /locus_tag="PQ460_RS20325"
                     /old_locus_tag="PQ460_20325"
     CDS             3682..5010
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277996.1"
                     /locus_tag="PQ460_RS20325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20325"
                     /product="SCP2 sterol-binding domain-containing protein"
                     /protein_id="WP_274170974.1"
                     /transl_table=11
                     /translation="MKKHPTVLRYYESVAQSTPVKNEILDYDWIRELCLDAGADDVGVI
                     SMERSELDDQREDILSVFPHAKTMISFVAKMNREPIRTPARSLANIEFHHTGDRVADIS
                     HNIVSTLEARGIRALNAAMGFPMEMDKFPGKAWVVSLKPVAVAAGLGKMGIHRNVIHPK
                     FGNFILLGAIILDAPVSKEDRPIDYNPCLECKLCVAACPVGAIGADGQFNFSSCATHNY
                     REFMGGFSDFVETVVESKNTKEFRSEVPATEAASWWQSLSFGANYKAAYCLSVCPAGDD
                     VIGPFLEDRKGFMKDIVKPLQAKEETIYVIPNSDAEAHVKKRFPHKTIKRVGNGLIPNS
                     IGLLVTLMPHVFQPNQSADLNCTYHFTFTGDENRQTTFDIRDEKLQVQDGLQGTPDIQI
                     TVDSKTWLKIVAKEKNVGVALLTGKLRLKGNPKLLMKFEKCFA"
     gene            complement(5157..5696)
                     /locus_tag="PQ460_RS20330"
                     /old_locus_tag="PQ460_20330"
     CDS             complement(5157..5696)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007131367.1"
                     /locus_tag="PQ460_RS20330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20330"
                     /product="GNAT family protein"
                     /protein_id="WP_274170975.1"
                     /transl_table=11
                     /translation="MQLETQQLLIREIQHSDWEAIHTYTQLPEVTQYTAWGPNTEADTK
                     AYVEEAIAQQQQSSRQDYEFAICLKDEGVLMGGIGIHVHNTNAEIGYVLNPDYQGNGYV
                     TEAARAILAYGFEILDVHRIYATCRPANIASEKVMQKIGMTREGIMREHWYYKGEFHDS
                     SLYSILAKEYIARSKS"
     gene            complement(5899..7695)
                     /locus_tag="PQ460_RS20335"
                     /old_locus_tag="PQ460_20335"
     CDS             complement(5899..7695)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660696.1"
                     /locus_tag="PQ460_RS20335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20335"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_274170976.1"
                     /transl_table=11
                     /translation="MLKELDIVAFIKSQKYFFILAYKENPSSFIWYMICKLIISVLPPI
                     VVLLNKKVIDSISNIHDQPYLLTLTIQLVIAVFLIQYISSLVNSFGDYIFTKISRDVNF
                     VLKKLLYEKILKIPYEEYEDSKFFDDISLSNIAISTSGINVIQNIITIIGSIISLLGML
                     GILLTIHWTMPLALFISTLPGIILLFAVKTKSYNISKETALKSRELDYTSDLFLNRSII
                     KEIKIYNTGEYLLNKWKTLFQYIQTHNLKLAFWEFKTTTFAVFVLQASSLVVSLLLIKQ
                     ISSNMLTVGDYVALLGAVTSVQGIFGMIGGSLGSIFETAIYNNSLIKVLNYELKNQIIN
                     NISSNKFEKLDINNLTFVYPQTDKKVLKNISMRIKKGENIAIVGHNGSGKTTLLNCLLG
                     LYSATDGQIKLNNHNIEEIDKVNLYNIMSAIFQDFGRYKYTVRENLSFGDLEKFNKDSE
                     LFDNLKKVDLYHKIINFDKKLDTYLTKEMPNGSELSGGEWQKLAIARGFLKNTDLIILD
                     EPTAALDPISELNIFEVFYKLAKNKTIITISHRLGPTRLADRIIVMDNGEIYEEGSFDE
                     LMSKKGMYYEMYLSQANWYKDK"
     gene            complement(7710..8216)
                     /locus_tag="PQ460_RS20340"
                     /old_locus_tag="PQ460_20340"
     CDS             complement(7710..8216)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PQ460_RS20340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PQ460_20340"
                     /product="hypothetical protein"
                     /protein_id="WP_274170977.1"
                     /transl_table=11
                     /translation="MNAEYQIIVSLIFMILVILFIIILVIHKSKVSKVINQGIKIGEKF
                     PNIIVYNSINQKVPLLKEIYSQKIDTLILIDVNCSQCEKVLKTLKIIKPEYLKNIRFLA
                     VGSEDITSKISNHSFQNQLLLAQMEDVINQIKVNGFPFIFKNNIDGTITSKGYISEDTI
                     TKYIN"
     gene            complement(8228..8746)
                     /locus_tag="PQ460_RS20345"
                     /old_locus_tag="PQ460_20345"
     CDS             complement(8228..8746)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="PQ460_RS20345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20345"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_274170978.1"
                     /transl_table=11
                     /translation="MEILSTIFHVGAGLVLLFSGISKIFSIKENQNELKFLKIIPHYLL
                     VPLSYLLPIFEVLLAISLLFRGDIIYVQILAIVLLLCFIFIHIDAMLNKKETKCFCFGN
                     VISAKHGLGGLIQTILLLLSLIPSVLYLPSSLYLLMSEGVNINFYIILISAFFWGIILV
                     LSRRLLDEI"
     gene            complement(8762..9175)
                     /locus_tag="PQ460_RS20350"
                     /old_locus_tag="PQ460_20350"
     CDS             complement(8762..9175)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="PQ460_RS20350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20350"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_274170979.1"
                     /transl_table=11
                     /translation="MILVTKVLFFLLGCFFLKNSITKFKKKYLFFEAINDYKIIKYEYL
                     VIILVPLLITIELFVSLNFIAGFSLSYIVLLAALLQLFYIFLNIKSLNKIFSNNCGCFS
                     LQIPRKVTAKNVLNNIIILFIIILLYGLKIRYH"
     gene            complement(9159..9611)
                     /locus_tag="PQ460_RS20355"
                     /old_locus_tag="PQ460_20355"
     CDS             complement(9159..9611)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PQ460_RS20355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PQ460_20355"
                     /product="hypothetical protein"
                     /protein_id="WP_274170980.1"
                     /transl_table=11
                     /translation="MSNYIYEIIIIFCILIYLYITFKIYTNRFFLKKKKIIKQNINHNY
                     TGYVILIFDNMLSYEIEIVKEIYNLAIKKQNVIFIDIKENNNIKAIEILKKLKINQFPA
                     VFYIENNKSIELFDFDNDFLYETSFENRKKGIESKLNGRLANDLSN"
     gene            complement(9731..9952)
                     /locus_tag="PQ460_RS20360"
                     /old_locus_tag="PQ460_20360"
     CDS             complement(9731..9952)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000634206.1"
                     /locus_tag="PQ460_RS20360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20360"
                     /product="hypothetical protein"
                     /protein_id="WP_274170981.1"
                     /transl_table=11
                     /translation="MKYVSPTLVECGNSMEVIKGECGWGTENATLDKTGAKKAYRNRTY
                     RVVTGQGPGAGYNACRRELVCETDSDQC"
     gene            complement(10001..11794)
                     /locus_tag="PQ460_RS20365"
                     /old_locus_tag="PQ460_20365"
     CDS             complement(10001..11794)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="PQ460_RS20365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20365"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_274170982.1"
                     /sec_met_domain="GATase_7 (E-value: 2.8e-13, bitscore:
                     48.0, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 5.6e-26, bitscore:
                     90.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITIRWFLAEINTNSMNCQKQKVEEYIKKEFNIEVYQKEVERFNN
                     RFTCCDSESLPEIQNNPIVILGDIDIHNQEMLKEKYGITKVLCIEDLLIHLYRNQGIDF
                     LNELVGEFSFILYDSDKKLTYAVRDHIGIKTLYWIKKGSKYIFANDIFILQDYFNIKDL
                     EMEYFKEFLNCNGIVDSELTPYKEIKRVSSGYYLELNDKLDHQIHNYWDLCNINGNIEF
                     LNEKEYEEKFKKIFFESVKSRLKKNDETSIMLSGGLDSTSIYAASKIISKEDKEKNQQI
                     SSISAVFNELKESDEQIYINELLDKYEDKGNYKEFDNELMYDNFPEDIPFSYEPHVSGL
                     TFEFTNRLVKGAAENGINRILTGFAGDQLLTGSLDVTNDFIKRGKLGKALSYVTKYSIA
                     TNSSAFKNFFKYTLSSNILDEEVKNKESSYYTKMKKKMKKIKYSHQKQLYYQISNAKAH
                     LYMDRTIGAIHKMDIKHPLLDRRLIEFIYTLPGELRFSDYHSKLILRNALGDILTERIK
                     NRINKTTHVAYTYKSIRTNWEKIYNILSKPQLIIKLGFISLEEWNKELMKWRNGIAVSD
                     SFWIMVAIELWISKYNTKVNN"
     gene            complement(11791..12174)
                     /locus_tag="PQ460_RS20370"
                     /old_locus_tag="PQ460_20370"
     CDS             complement(11791..12174)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714527.1"
                     /locus_tag="PQ460_RS20370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20370"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_274170983.1"
                     /sec_met_domain="PF13471 (E-value: 5.8e-16, bitscore: 56.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDFKLHKIGFTNIFDLYSKKNFLEKSKNINIVDYEKFSERINFE
                     FNVLDMVCTWYPRKADCIHKTFLGYKILRKKYHIQVDMVVGIRKFPFEAHAWLIEEDRN
                     FFGDEEETNKYKIILNSNDFMGG"
     gene            complement(12224..12484)
                     /locus_tag="PQ460_RS20375"
                     /old_locus_tag="PQ460_20375"
     CDS             complement(12224..12484)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="PQ460_RS20375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20375"
                     /product="PqqD family protein"
                     /protein_id="WP_274170984.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.1e-14,
                     bitscore: 51.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.3e-13, bitscore: 46.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNKINKHLIVYEEDEEIILLNLVDNKFFALDFISSIFWKQINLE
                     KENKEIVDYISKQFEVTKEQVQKDLEIFLRDLKKSGVIITE"
     aSDomain        complement(12233..12472)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PQ460_RS20375_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.30E-16"
                     /identifier="RREFam002.1"
                     /label="PQ460_RS20375"
                     /locus_tag="PQ460_RS20375"
                     /protein_end="84"
                     /protein_start="4"
                     /score="51.4"
                     /tool="antismash"
                     /translation="INKHLIVYEEDEEIILLNLVDNKFFALDFISSIFWKQINLEKENK
                     EIVDYISKQFEVTKEQVQKDLEIFLRDLKKSGVII"
     gene            complement(12697..13974)
                     /gene="purD"
                     /locus_tag="PQ460_RS20380"
                     /old_locus_tag="PQ460_20380"
     CDS             complement(12697..13974)
                     /EC_number="6.3.4.13"
                     /GO_function="GO:0004637 - phosphoribosylamine-glycine
                     ligase activity [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009592291.1"
                     /locus_tag="PQ460_RS20380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20380"
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="WP_274170985.1"
                     /transl_table=11
                     /translation="MDILVVGGGGREHAIIWSLAKSPKADKIYCAPGNAGIAQLAECVP
                     IQVNEFEKLADFATEKKVGLVVIGPDDPLADGIVDVFEKHQIPVYGPRKNAALIEGSKT
                     FMKDLLHKYNIPTAAYAKFDDYESALTYLQQQSTPIVIKADGLAAGKGVTVAHDMDEAI
                     DALQSIMQDKVFGEAGSKVVIEEFLAGQEMSILAFVDGETVRPMPAAQDHKPAYDNDLG
                     PNTGGMGTYSPLPHIKQSIIDQAIETIIVPTAKAMVAEGRSFSGVLFAGLMISPDGTPK
                     TIEFNARFGDPETQVVLPRLESDLLEIFLATVNGTLADIEIKWSEEAAVCVILASGGYP
                     AAYAKGLPISGLQHTDEQALVFHAGTAQGQNGEVVTNGGRVLGVVGLGANIASARTKAY
                     EQAAKITFEGKHQRSDIAAKALFKIN"
     misc_feature    14145..14157
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.88"
                     /tool="antismash"
     gene            complement(14313..15860)
                     /gene="purH"
                     /locus_tag="PQ460_RS20385"
                     /old_locus_tag="PQ460_20385"
     CDS             complement(14313..15860)
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0003937 - IMP cyclohydrolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004643 -
                     phosphoribosylaminoimidazolecarboxamide formyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006208291.1"
                     /locus_tag="PQ460_RS20385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20385"
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="WP_274170986.1"
                     /transl_table=11
                     /translation="MSIKRALVSVSDKAGVVDFCRELSQLGVEIISTGGTKNLLAEAGV
                     PVIGISDVTGFPEILDGRVKTLHPAVHSGLLAVRDSAEHQQQMKDLELGYIDLVVVNLY
                     PFQETISKPDVAYEDAIENIDIGGPTMLRSAAKNHAFVSVVVDSSDYAKVLEEVRAEGD
                     TTLDTRKRLAAKVFRHTAAYDALISDYLCEVLGDPLPERYTVTYEKIQDLRYGENPHQA
                     AAFYRKPMAPAGTLTTAEQLHGKELSYNNINDANAALQIVKEFTEPAVVAVKHMNPCGV
                     GVGETIAEAYNKAYNADPTSIFGGIVAANRTIDAATAQPLSEIFLEIVLAPDFTSEALE
                     ILTKKKNIRLLKMGELTSSEERTAQHVVTTIEGGMVVQESDVHSITTDDLKVVTDRSPS
                     GEELKQLLFGWKVVKHVKSNAIVLAADDMTVGVGAGQMNRVGAAKIAIEQAGDKANGAI
                     LASDAFFPMGDTVELAAKAGIKAIIQPGGSIKDEESIKMANEYGIAMVFTGVRHFKH"
     gene            complement(15896..16519)
                     /gene="purN"
                     /locus_tag="PQ460_RS20390"
                     /old_locus_tag="PQ460_20390"
     CDS             complement(15896..16519)
                     /EC_number="2.1.2.2"
                     /GO_function="GO:0004644 - phosphoribosylglycinamide
                     formyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /NRPS_PKS="Domain: F (83-169). E-value: 6e-16. Score: 50.4.
                     Matches aSDomain: nrpspksdomains_PQ460_RS20390_F.1"
                     /codon_start=1
                     /gene="purN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228: methionyl-tRNA formyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015842495.1"
                     /locus_tag="PQ460_RS20390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20390"
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="WP_274170987.1"
                     /transl_table=11
                     /translation="MKPFRIAVFASGEGTNFQAMVDAWQDGYFGKPDATTIELLVSDKP
                     QAPVVQRAIQAGVDTYVFHPKEYSSREQYELEIVAELQRREIDLIVLAGYMRLLTPTIV
                     DPYMGRMINVHPSLLPAFPGKDALGQALSYGVKVTGITVHFVDNGMDTGPIIAQQSIEV
                     QQQDTAETLAERIHDIERKLYPQVVAQIAKGKVTLEGRQVIVEA"
     aSDomain        complement(16013..16270)
                     /aSDomain="F"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PQ460_RS20390_F.1"
                     /evalue="6.00E-16"
                     /label="PQ460_RS20390_F.1"
                     /locus_tag="PQ460_RS20390"
                     /protein_end="169"
                     /protein_start="83"
                     /score="50.4"
                     /tool="antismash"
                     /translation="RREIDLIVLAGYMRLLTPTIVDPYMGRMINVHPSLLPAFPGKDAL
                     GQALSYGVKVTGITVHFVDNGMDTGPIIAQQSIEVQQQDTA"
     gene            complement(16519..17562)
                     /gene="purM"
                     /locus_tag="PQ460_RS20395"
                     /old_locus_tag="PQ460_20395"
     CDS             complement(16519..17562)
                     /EC_number="6.3.3.1"
                     /GO_function="GO:0004641 -
                     phosphoribosylformylglycinamidine cyclo-ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819771.1"
                     /locus_tag="PQ460_RS20395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20395"
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="WP_274170988.1"
                     /transl_table=11
                     /translation="MSEAYKSAGVDIAAGNEAVERMKKHVKTTFRPEVMTELGGFGALF
                     GLNKDKYDEPVLVSGTDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDIVVQGAEPLFFLD
                     YLACDRVIPEKIEAIVSGIADGCRQAGCALIGGETAEMPGMYSEGEYDIAGFTVGIVDK
                     AKVITGSEIAAGDVVLGLASSGIHSNGFSLVRKLLLEDAGYDLKDTVTELGNAVLGDVL
                     LEPTKIYVKSTLALQEAVKVKGMAHITGGGFIENIPRMLPEHVNVDIEYGNWPILPIFQ
                     LMQAKGGISHKDMFTTFNMGIGMVIVVPADQAEQALTLLAEQGETAYQIGTVQEGNKVV
                     TFTGVDV"
     misc_feature    18125..18143
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.35"
                     /tool="antismash"
     gene            complement(18581..20059)
                     /gene="purF"
                     /locus_tag="PQ460_RS20400"
                     /old_locus_tag="PQ460_20400"
     CDS             complement(18581..20059)
                     /EC_number="2.4.2.14"
                     /GO_function="GO:0004044 - amidophosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426172.1"
                     /locus_tag="PQ460_RS20400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20400"
                     /product="amidophosphoribosyltransferase"
                     /protein_id="WP_069328924.1"
                     /sec_met_domain="GATase_7 (E-value: 5.7e-24, bitscore:
                     82.5, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDELNKQTLWTGDYYNQGTGPNDIFDTLKEECGVFGVYGHSEAA
                     SLSYYGLHALQHRGEESAGLCVSDRNQFHYHRGMGLVKEVFDKDTLGSLTGDISIGHVR
                     YSTSGDSRLTNAQPLVFRYRAGELALATNGNIVNAPQIRRELEEAGSIFQTTSDTEVVA
                     HLIARSNKPLVEAAKDAFRQIVGGFAFMIMTNEQLIVASDPNGLRPITMGRLGEAYIFA
                     SETCALETIGAELVRDVQPGELLILDQHGLIEDRYIEPQRKALCSMEYIYFARPDSDMN
                     GANLHAARKRMGSVMAQESFIDADLVTGVPDSSISAAIGFAEQTGIPYELGMIKNKYTG
                     RTFIQPSQELREQGVKMKLSAVRRVVEGKRVVMIDDSIVRGTTSRRIVNMLRDAGATEV
                     HVRITSPPFKNPCFYGIDTPDRRELIASTMSIEEMRKELNADSLTFLSFEGLIKAVGGD
                     NSTDYKGGMCMACFDNDYPTQTDFGGEEQFGCGC"
     gene            complement(20044..22290)
                     /gene="purL"
                     /locus_tag="PQ460_RS20405"
                     /old_locus_tag="PQ460_20405"
     CDS             complement(20044..22290)
                     /EC_number="6.3.5.3"
                     /GO_function="GO:0004642 -
                     phosphoribosylformylglycinamidine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012819096.1"
                     /locus_tag="PQ460_RS20405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PQ460_20405"
                     /product="phosphoribosylformylglycinamidine synthase
                     subunit PurL"
                     /protein_id="WP_274170989.1"
                     /transl_table=11
                     /translation="MMQQTSVKEPTAEQVADQQIYKQMGVSDSEYELICGFLGRKPNYT
                     EIGVFSVMWSEHCAYKNSKPLLRRFPTSGPRVLMGPGEGAGIVDIGDNQAVVFKIESHN
                     HPSAVEPFQGAATGVGGIIRDIFSMGARPVAVLNSLRFGKLESERVKYLFEHVVSGIAG
                     YGNCIGIPTVGGEVMFDESYDGNPLVNAMCVGLIDHDKIQRGVAKGVGNPVFYVGPPTG
                     RDGIHGATFASEELTEESEARRTAVQVGDPFMEKLVMESCLELIDSGIVLGIQDMGAAG
                     LTCSSAEMASKAGNGLELYLDQVPQREDGMTAYEMMLSESQERMLFVVEPKDEAQAMEI
                     FERWGVICAKVGKVTDDGRLKLLHHGEVVGDMPVHALVDECPIYDKPSSVPAYYEQQAN
                     VDTNRYDEVTDLSGALKSILASPTVASKAWVYDQYDYMVRTSTAVRPGSDAAVITIRGT
                     RKALAMTTDCNGRYVYLDPEVGGKIAVSEAARNIVCSGAEPLAITDNLNFGSPEKPDIF
                     WQMEKSVDGMAEACRVLDTPVIGGNVSLYNENTRGAIYPTPVVGMVGLVHDTDHITTQG
                     FKNEGDIIFVLGDTFAELGGSEFQKVVHNVTEGRPPALDLEIEKKLLGSVLSAIQSGLV
                     QSAHDLSEGGLSVALAESCISGKLGASVALSSDNLRHDLLLFSESQSRILLSATPAQAD
                     ALESHIQSQGVPVRRIGQVQGTELQIQVDGKQVLAEQVNNLRQVWEDAIPCLMN"
ORIGIN
        1 acttgcccaa cccgatcgaa gaccgagacg tgcaaatcca atcgctgcat tggcttcagc
       61 tcctgctaat cgtttaataa ataaagccac atcatgcaga tcgcctactt cttcagctac
      121 aaacatagtc attgcttcgc caaatgtcac aatgtccagt gatgtgttat cactttctac
      181 aggtaagttg gatgatggta aaagctcatt tccatttact ctagcagtat ctgttgtgtg
      241 atccattgca atgttgctcc ttcctgctgt gcttagtaca tggttgtaat atttaatctc
      301 tgtatcatca gataaagtaa attcgatcgc ccgccatgct tgattcggaa gaagttcgat
      361 tacttgtcgc cataatgctt tttcctctat cggtaaagga agcgttagat atctattctc
      421 ttgctgaacc gaatgcttcg catgaatata agtcacataa ggtgataatt gttgcgccgc
      481 ttccagtgca tcttgtcctg catacaacca gttaccgata tcgaatgtta ttccgatcga
      541 ataccattgc gaatgcgctt gcaaagtagc taattgttca aaaaacgaaa gtatatgtgc
      601 aggatctccc ccgtatgttg tctgatcgtt ttctatccat agacgaattg gagataccga
      661 tgactgttca gcaaaaaatt gatccaaact tgtaagcaat acatctatag aagattgcac
      721 atgatcgtaa tgaccaagtg ataacttgac tgcatctgct cctaatcgct gtgcttctgt
      781 gaaagaacga tatactattt cttgattcag tccatgattc ttttgccata acgatgcagg
      841 tacagaataa acggtatata aaagattagc ttgttgaatc gcttgtctac actgttctaa
      901 aggcaaacta tcgtctgact ctacaaaaag ttcacgacga atctctatgc cctgtgctcc
      961 aagatcagca atacgtgtag tcacttgtga ttgtgtaact tttccactaa cgacatctgc
     1021 aaaaacagaa gtcggaataa tagtaatcga cattgataat ctcctttcta ctacaaagta
     1081 gagcattact atctatttca tctgctcaat tcatatgaaa atgttcaaca caataagtta
     1141 atttcaattt aataaatcgg tttagtaaat cggtttatga ggtcagtata atgcaactat
     1201 tttataaata caagtctttt tgtaaacgtt atctgtattt atatggtaaa aggtactttg
     1261 gacccattct gaaataaata actaataatt aactaataaa tataaattta tttgcattta
     1321 aattcataat tatgtatatt tattttttac atataaagga gatgatgttt ttggaaactg
     1381 tgccgacagt gattcgtcaa gcaactacag cagatgtcga agcgttgata actattatga
     1441 atgaatatat tggagacttt tatcaaaagc ccaaaccgcc tgtagaaaag ctacatcatc
     1501 tgatcacgac gttattggat ctgcaattag gggtacaatt tgtagtcgag caaaatgatc
     1561 agaccgtagg atttgcaaca ttatactttt cattcagctc gatcaaagcc gataaagtca
     1621 caattatgaa cgatctttat ctgcaagagc atttacgaga tactgaagtg gaagttcaat
     1681 tgtttaagca ctgccagacg tatactcaag atcatggatt tgctcatatg agctgggtag
     1741 ctgcaccgca taatacacgt gcgcatcgct tttttgatcg aatgggatgt acgagagtcg
     1801 attgggtcga ttatatgatt gtatagcacc aaaaaagacc gtccaacatc aagttgatca
     1861 gatgttggac ggtctttttt ttgatcacaa acgtatagtt ctatcttcat tctgatgatc
     1921 aaatattcat tttattgtat attcagcggt tgtgccgaag attcgcggat cattaatgta
     1981 caagtaaatt gcttttcttg tatagctggt tgttcttgtt gtgtactctg tgcagaaatc
     2041 gaagcaagta acatttctgc ggcttgtctg cccatgtcat gcgaaggttg aacaatcgta
     2101 gacaatgtag gggttagcaa ttcagcaaac ggtatattat caaatacgat caatgccata
     2161 tcttgcggaa tctgcaattg atattctttg agaaaagcaa gaacttcaag caataccaga
     2221 tcgttacctg caataattgc tgttggtaat tgctgttgct gtgcccagat gcttaatgta
     2281 tgacgtaatt gcttaacttc atccgataat atcatcggtg tgatctgtgg taatagctcc
     2341 tccattgcac gtgtatatcc atgtactcgc tctacacgag tagaaataga cagcggtgct
     2401 gtgagcattg caatatgttg gtgccccgta tggatcagat gttctgtcgc tttatacgca
     2461 gcttgttcat tatctacaac gacacgactt acctgtaccc cttccagctt ccgatctaca
     2521 aatactaatg ggaagccttc ttgaactagc ttctgataca aaggagttaa ttgaccggac
     2581 ggaaaagcaa tcactccatc tacttgcttg gagcgcaaca attccagatc ttcacgttct
     2641 cttgcttcat cttcatcggt attgcataga attacgctaa tgccctgttc ccggcaataa
     2701 ctctcaatcc cccgacagat ttccaaagaa aattgatgca acatatttgc aacgattacg
     2761 ccaatcgtaa acgtacgttt ttgtttgaga ctgcgtgcca gtacattcgg acgataatcc
     2821 aatgcctgaa tcgccgcagc tattttatct tttgtattac tgctcatata ttcataacgc
     2881 ccgttaagat attgggagac tgtacttttg gatactcctg cttcacgagc tacatctgcc
     2941 attgtcattt tcgccatagt tactgccctt tctctatgat ccgagtgtag ttacagatgc
     3001 tcatacggat atggttgatc tgtgtttgaa tattatcata gcgtaaggac tcattgtagc
     3061 acaaatggct atttttgaag aatatctcat ctggttgcta cgctgtaaaa caagcataaa
     3121 gattgacatc aacaaatatg tgtatatact catatttatg agaaacgata attctaatct
     3181 gcccaaaaca atcgattaca cagcagagtg cgcctgctta aattttagaa aagcgtcacg
     3241 ttttattact agcctatatg atgagtattt aagacctgta gggcttcgag caacccagtt
     3301 atcattgctg atggcacttg aacaagcagg atcggtcact attacgactc ttgctgaatt
     3361 acttttgatg gatcggacta cactaccacg cgatctaaaa ccacttgaac gaaatggatg
     3421 ggtatcaatt acaccaggag aggatcgtag aaaacgtttt attgctttga cacctgacgg
     3481 tcagcacctt cttaacacag ccttaccact atgggaacaa gcacaagttc gtgtacaaga
     3541 gtatatgggc gaagatcgtt atagaggttt acttggacaa ttatctgata ttgtgaagct
     3601 aaatagacaa aattaatttt ttttgattaa ttaggtgtat atacacttat tttagaaagg
     3661 atcgatatat atatggctga tatgaaaaaa catcctactg ttcttcgtta ttatgaatcg
     3721 gttgcgcaat ctacccctgt caaaaatgaa attcttgatt atgattggat acgtgaatta
     3781 tgtctggacg ctggagcaga tgatgtcgga gtgatttcta tggaacgctc cgaattggat
     3841 gatcaacgtg aagatattct atctgtattt ccacatgcta aaacgatgat tagctttgtt
     3901 gctaaaatga accgagaacc gatccgtacc cctgctcgct cacttgctaa tattgaattt
     3961 catcatacag gggatagagt ggcagatata tctcataata ttgtatccac attagaagca
     4021 cgaggcatac gggctttgaa tgcagctatg gggttcccga tggaaatgga taagtttccc
     4081 ggcaaagcat gggtcgtttc acttaaacct gtagcggttg cagcaggctt aggtaagatg
     4141 gggattcatc gcaatgtcat ccatcccaaa ttcggtaatt ttattctact aggcgctatc
     4201 atactagacg ccccggttag caaagaagac cgtccaatcg actataatcc ttgtctggaa
     4261 tgtaaacttt gcgtagccgc ctgcccggta ggtgcaatcg gagcagatgg acaattcaat
     4321 ttctcatctt gtgctacaca taattatcgg gaatttatgg gtggttttag cgattttgta
     4381 gagacggtag tagagagcaa aaatacgaaa gaatttcgga gcgaagtacc agcaactgaa
     4441 gcggcttcgt ggtggcaaag tttgagtttt ggtgctaatt ataaagcggc ttattgctta
     4501 tctgtgtgtc cggcaggcga tgatgtaatc gggccatttc tagaagatcg aaaaggattt
     4561 atgaaagata tcgtaaaacc gttgcaagca aaagaagaga ctatttatgt gataccgaat
     4621 tcagatgcag aagcgcatgt caaaaaacgt tttcctcata aaacgatcaa acgtgttggt
     4681 aatggactga tacccaattc gataggtctt ctggtgactc ttatgcctca tgtatttcag
     4741 ccgaatcagt cagcagactt aaactgcacg tatcacttta cgttcacagg cgatgaaaat
     4801 agacaaacca cattcgatat tcgagatgaa aagcttcagg tacaagacgg tctacagggt
     4861 acacccgaca tccagattac agtagacagc aaaacatggc ttaaaatcgt agcgaaagaa
     4921 aaaaatgtag gcgtagcctt actcacagga aaactacggc tcaaaggtaa tcctaaattg
     4981 ctgatgaaat ttgaaaagtg ctttgcctaa tagcaaacgt aacataatac tagagtacat
     5041 ttttattttg taattgatat gaaaaagaaa ccctgataag tgataccgtt cagggtttct
     5101 tttttttagt ttagcatgta ataacagaga catatcccta tataagctaa tattacttat
     5161 gatttggagc gagctatata ttcttttgca agtatagaat acagagaaga atcatgaaat
     5221 tcgcctttat aataccagtg ttcacgcata atgccttcgc gtgtcattcc aatcttctgc
     5281 atcactttct ctgaagcgat attagcgggg cgacaggtag catagattcg atgtacatcc
     5341 aatatctcaa atccataagc caatatagca cgcgcagctt ctgttacata accgttgccc
     5401 tggtaatcag gattcagcac gtaacctatt tcagcgttag tgttatggac atgaataccg
     5461 atcccaccca tcaatacccc ttcatctttc aagcaaatag caaattcata atcttgacga
     5521 gaagattgct gttgctgagc gatagcctct tcaacatatg ccttagtatc tgcttcagta
     5581 ttaggccccc acgcagtata ttgggtcacc tctggcaatt gcgtataagt atgaatcgct
     5641 tcccaatcac tatgttgtat ttcacgaata agcagttgct gtgtttctaa ttgcatatgt
     5701 aagtcctcca actcgaaata ttttttatgt taaaaatgga aaaaatataa atattatact
     5761 aatagagatt aatatcaata tttaatttat aattagaact cacatttatt attggaaaaa
     5821 aatagttcat taagctttta aaaataaagc ttaatgaact atcctatatt taaattttga
     5881 agttatctta atttatattc atttatcttt ataccaattg gcttgagaaa gatacatttc
     5941 ataatacatt ccttttttac tcatgagttc atcaaatgaa ccttcttcat atatttctcc
     6001 attatccata actataattc gatcagctaa ccttgttggt cctaatcgat gtgatattgt
     6061 aataatagtt ttattttttg ctaatttata aaaaacctca aaaatattta attcacttat
     6121 tggatctaat gctgcagtag gctcatctaa aatgataaga tctgtatttt taagaaagcc
     6181 tctagcaatc gctaatttct gccattctcc accagacagt tcacttccat ttggcatttc
     6241 ttttgttagg taagtatcta gctttttatc aaaattaatt attttatgat ataaatcaac
     6301 ttttttcaag ttatcaaata gttctgaatc tttattaaat ttttctaaat ctccaaaact
     6361 taaattttct ctaaccgtat acttatatct accaaaatct tgaaaaatag cagacatgat
     6421 attatataag ttaactttat ctatttcttc gatgttatgg ttatttaatt ttatttgtcc
     6481 atcagtagca ctatataatc caagtaaaca atttagtaaa gttgtcttac ctgaaccatt
     6541 atgacctact atagcaatat tttctccttt ttttatacgc atagaaatat ttttcaatac
     6601 ttttttatca gtttgaggat aaacaaatgt taagttatta atatcaagtt tttcaaattt
     6661 atttgatgaa atattattaa taatttgatt cttcaattca taatttaata ctttaattaa
     6721 agaattgtta tagatagcag tttcaaatat cgaccctaaa cttccaccaa tcataccgaa
     6781 tattccttgt accgatgtta cagctcctaa taatgcaaca taatcaccaa ctgtcaacat
     6841 attggaggaa atttgtttaa ttaaaagtag cgaaactacc agacttgaag cttgtagtac
     6901 aaaaacagca aaagtagtag tcttgaattc ccaaaatgct aattttagat tatgtgtctg
     6961 aatatattga aaaagagttt tccatttatt taataaatat tcaccagtat tatatatttt
     7021 aatttctttt ataatacttc tatttaaaaa aagatcagaa gtatagtcca actctctaga
     7081 tttcaaagca gtttctttgc taatattgta acttttagtt ttaacagcaa aaagcagtat
     7141 tataccaggc aaagtcgata taaacaaagc taaaggcatg gtccaatgta tagttaaaag
     7201 tattcctaac atacctaata atgaaattat acttcctata attgttatta tattttgaat
     7261 aacattaatc ccactggtag aaattgcaat attcgataaa ctaatatcat caaaaaattt
     7321 actatcttca tattcctcat atggtatttt taatattttt tcataaagta atttttttaa
     7381 aacaaaattg acatcccgag aaattttagt gaaaatataa tcaccaaagc tatttactag
     7441 cgatgatata tactgaatta aaaaaacagc tattactaat tgaatagtca atgttaataa
     7501 atagggttga tcatgaatat tacttattga atctataact tttttattaa gtaaaactac
     7561 tatagggggt agaacagaaa taataagttt acatatcata taccaaataa aactacttgg
     7621 attctcttta taagctaata taaaaaaata cttttgactt ttaataaatg ctacaatatc
     7681 tagttctttt agcataagta cctcttaatt caattaatat atttagttat agtatcttcc
     7741 gaaatgtatc ctttggaggt aattgttcca tcgatattat ttttgaaaat aaaaggaaac
     7801 ccattcactt ttatttgatt gattacatct tccatttgcg ctaataataa ttgattttga
     7861 aatgaatgat tagatatttt agaggtgata tcttcagatc cgacagccaa aaaccttata
     7921 ttttttaaat attccggctt aataattttt aaagttttta aaactttttc gcattgacta
     7981 caattaacat ctattaaaat taaagtatct attttttgag aataaatttc ctttaataag
     8041 ggtacttttt gattaataga attatagact attatatttg gaaacttttc tcctattttt
     8101 ataccttgat tgattacttt tgatacttta gatttatgta taactagtat aataataaat
     8161 aagataacta aaatcatgaa aattaatgaa acaataattt ggtattcagc attcatattt
     8221 ttctccttta aatttcatct aataatcttc tagatagtac taaaataatg ccccagaaaa
     8281 aagcacttat taaaattata taaaagttta tatttacgcc ttcactcatt aataaataca
     8341 agctagaagg taaatataat acactaggaa ttaagctcaa aagtagaagt atagtctgaa
     8401 ttaagcctcc taagccatgc ttagcactta tcacattacc aaaacaaaag catttcgttt
     8461 cttttttatt tagcatggca tcaatatgta taaaaataaa gcataatagt aacactatgg
     8521 ctaatatttg cacataaata atatctccac gaaaaagtaa agatatagct aaaagcactt
     8581 cgaaaatagg caataaataa cttaaaggta ctaacaaata atgaggtatt atttttaaaa
     8641 attttaactc gttttgattt tctttaatag aaaaaatctt acttatacct gaaaacaata
     8701 aaactaaacc tgcaccaaca tgaaatatcg tagacagaat ttccataatg tattcctcta
     8761 ttcaatgata tctaattttc aaaccatata ataatataat aataaacaga attataatat
     8821 tatttagtac gtttttagct gttacttttc taggtatttg taacgaaaaa cagccacaat
     8881 tattactgaa tattttattt aaacttttta tgtttaaaaa tatataaaac aattgtaaaa
     8941 gtgctgctaa taagacaata taggataaag aaaaaccagc aataaaattt aaagatacaa
     9001 ataattcgat tgtaatgagt aaaggtacca gtataataac taaatactca tattttataa
     9061 ttttataatc attaatagct tcaaaaaata aatatttctt cttgaattta gtaatactat
     9121 ttttcaaaaa aaaacaacct aataaaaaaa ataggacctt agttactaag atcattagca
     9181 agcctcccat ttaactttga ttcaatacct ttttttctgt tctcaaaaga ggtttcatat
     9241 aaaaaatcat tatcaaaatc aaataattcg attgatttat tattctcaat gtaaaagacc
     9301 gcaggaaatt gatttatttt taattttttc aatatttcta ttgctttaat attattgttc
     9361 tctttaatgt ctataaatat aacattttgt ttttttatag ctagattata tatttctttg
     9421 acaatttcta tttcatacga caacatatta tcaaatatta aaattacata tccagtgtaa
     9481 ttatgattaa tgttttgttt gataattttt ttctttttca gaaaaaacct attagtatat
     9541 atcttgaaag taatatacag atatatcagt atacaaaaaa ttattattat ttcataaatg
     9601 taattactca taagccactc catataatta attaagatcg caccacatta aatatgatgc
     9661 gatcatataa caatattatg ctatttataa ggttttttat tttagtaaat tttttttgat
     9721 taattaattt ttagcactga tcactatcag tttcacatac tagttctcta cggcaagcat
     9781 tataacctgc acctggcccc tgacctgtaa caacacgata agttctattt ctgtaagctt
     9841 ttttagctcc agttttatcc aaagtagcgt tttcagttcc ccaaccacat tcacctttga
     9901 taacttccat actatttcca cattctacaa gtgttggact aacatatttc attaataatt
     9961 cctcctattt ttaccttata aatagcacaa tagtcttata tcaattatta actttagtat
    10021 tgtattttga tatccatagt tcaatcgcta ccatgatcca aaagctatct gatacagcaa
    10081 ttccattacg ccatttcata agttctttat tccattcctc tagagaaata aagcctaatt
    10141 taataattaa ttgaggttta gataaaatat tatatatctt ttcccaattt gttcttatac
    10201 ttttatatgt ataagctaca tgtgtcgttt tatttatacg attttttatt ctttctgtta
    10261 gaatgtctcc taatgcgttt ctcaaaatca atttactatg gtaatctgag aatcttaatt
    10321 cgcctggtaa agtatatata aattcaatca atcttctgtc tagcaatgga tgttttatat
    10381 ccattttatg aatagcacct attgttctat ccatatacaa atgagctttt gcattactaa
    10441 tttgataata caattgtttt tgatgagaat attttatctt cttcatcttt ttcttcattt
    10501 ttgtatagta gctactttct ttatttttca cctcctcatc cagaatatta gaagatagtg
    10561 tatacttaaa gaaattttta aatgcagagc tattagtagc aatcgaatat tttgtaacat
    10621 aagaaagtgc tttgcctaac tttcctcttt tgatgaaatc atttgtaaca tctaaagaac
    10681 ctgttaataa ctgatctcca gcaaacccag ttaatatccg atttattcca ttttcagctg
    10741 cacctttaac taatctattg gtaaactcaa atgtcaaacc actaacatgt ggctcatatg
    10801 aaaatggaat atcctcagga aaattatcat acattaattc attgtcgaat tctttgtaat
    10861 ttcctttatc ttcatatttg tctagtaatt catttatata aatttgttcg tccgattctt
    10921 taagttcatt aaatacagca cttattgaag atatttgttg gtttttttct ttatcttctt
    10981 ttgatattat ttttgaagct gcatagattg aagtagaatc taatccgccg cttagcataa
    11041 tcgaggtttc atcatttttt tttaatctag actttactga ttcgaaaaat atttttttga
    11101 atttctcttc gtattctttt tcatttaaga attcaatatt tccatttata ttacataggt
    11161 cccagtaatt atgtatttga tgatctaact tatcatttaa ttctaaataa taaccactgc
    11221 ttactctttt tatttcttta taaggagtta attcactatc tactattcca ttacaattta
    11281 aaaattcttt aaagtattcc atctctagat ctttaatatt aaaataatct tgtaatataa
    11341 aaatatcatt tgcaaatata tatttgcttc cttttttaat ccaatacaac gtttttattc
    11401 ctatatgatc tcttacggca taagtcaatt tcttatcact gtcatatagt ataaatgaaa
    11461 attctccaac caattcattc aaaaaatcta ttccttgatt tctatataag tgaattaata
    11521 aatcttctat acataatact ttagtaattc catatttttc ttttaacatt tcttgattgt
    11581 gtatatctat atcacctaga attactattg ggttattttg tatttctggt aaagattcac
    11641 tatcacaaca tgtaaatcta ttattaaatc tttcaacttc tttttgatat acttctatat
    11701 taaattcttt ttttatatac tcttcaactt tttgcttctg acagttcata ctgttagtat
    11761 ttatttctgc taaaaaccaa cgaattgtaa tcaacctccc ataaaatcat ttgaatttaa
    11821 aatgatttta tatttatttg tttcttcttc gtcaccaaaa aaatttctat cttcttcgat
    11881 caaccacgca tgcgcttcga aaggaaattt tctaattcct actaccatat caacttggat
    11941 atgatatttt tttctgagaa tcttatatcc taaaaaagtt ttatgtatac aatctgcttt
    12001 tctaggatac caggtacata ccatatctag cacattaaat tcaaaattta ttctttcaga
    12061 gaacttttca tagtcaacaa tattaatatt cttacttttt tctaaaaaat tcttttttga
    12121 atacagatca aaaatatttg taaaacctat tttgtgtaat ttaaaatcaa acattatcaa
    12181 taataaatat aaacgaataa atgttaagaa agttaaaatt ttgctattca gttataatca
    12241 ctcctgattt cttgagatct ctcaaaaaga tttcaagatc tttttgtact tgttcttttg
    12301 ttacttcgaa ctgtttactt atgtaatcta ctatctcttt attttctttt tctaaattta
    12361 tttgcttcca aaaaattgat gatataaagt ctaatgcaaa aaacttatta tctactaaat
    12421 tcaataaaat tatttcttca tcttcttcat aaactattaa atgcttatta attttatttt
    12481 tcatttattc acctattata aaactatttt aatacttttt tcttaaacat ctacttaata
    12541 aatctatact ttctaaaaaa ttatatatca aatttttgat ttttctaatc atacattact
    12601 aaaaaaaata tgtcaataaa aaacataaat ttcttttaga atccatattt agtagaagtc
    12661 tagattaaaa cttccaaact tctactaatt ttatctttaa tttattttaa aaagagcttt
    12721 ggctgcaata tcactacgtt gatgcttacc ttcaaatgta atttttgcgg cttgttcata
    12781 cgctttggtg cgggctgaag cgatatttgc tcctaagcca actacaccca gtacacgtcc
    12841 accgtttgtc acgacttcac cgttctgacc ttgcgctgta cctgcatgaa aaacaagtgc
    12901 ttgttcatcg gtatgctgta gtccgctgat tggcaatcct ttagcataag ccgctggata
    12961 accgcctgaa gccaaaatca cacatactgc ggcttcctcg ctccacttga tctcaatatc
    13021 tgcaagtgta ccgttaaccg tcgctagaaa aatctcaagt aaatcacttt ctagacgcgg
    13081 taataccact tgcgtctctg gatcgccaaa gcgtgcgtta aattcaatcg ttttgggcgt
    13141 accatctggt gagatcatta gcccggcaaa taatactccg ctaaatgaac gtccttcggc
    13201 aaccatcgct ttagctgttg gtacaataat cgtctcgatc gcttgatcga taatactttg
    13261 cttgatatgt ggtaatggtg aataggttcc cattccacct gtatttggac ctagatcatt
    13321 atcgtatgct ggcttgtgat cttgcgcagc aggcatggga cgaaccgttt ctccatcgac
    13381 aaaagccaaa atcgacattt cttgtccggc tagaaattcc tcgataacca ctttgctacc
    13441 ggcttcacca aatactttat cttgcataat ggactgtaac gcatcgattg cttcatccat
    13501 atcatgagcg acagttaccc ctttacctgc ggcaagtcca tcggctttga taacgatagg
    13561 tgtagattgt tgctggagat aggtgagtgc agactcataa tcgtcgaact tcgcatacgc
    13621 agcagttgga atattgtatt tatgaagcaa gtctttcata aatgttttgc taccttcgat
    13681 aagtgctgca tttttgcgag gcccatagac aggaatttga tgcttttcaa aaacatcgac
    13741 aattccatca gctaacggat catccgggcc gatcacgacc aaacctactt ttttctcagt
    13801 cgcaaaatca gctaactttt caaattcatt cacttgaatc ggaacacatt ctgctaattg
    13861 tgcaatccct gcattaccag gtgcacagta gattttgtct gcttttgggc ttttggcaag
    13921 tgaccagatg attgcatgct cacgtccgcc accacccaca actaaaatat ccataacgtc
    13981 acgctccttt gaatagagaa ggatttttcc aactatgttc aagcattatt tcacttttac
    14041 aaaagtctca aactagcata ataacgctct acatcgagta cattaagcaa gtgcacccaa
    14101 ctaacaaagc aacagaccga acaagaaata ttcggtctgt tttgttgctt attgcaagtg
    14161 gatttatagg aataccaagc attattgatc acgatctatc atcaacattt ttgcactctt
    14221 tctaaatact atcttgaagt gcttaactgt tgacgaattt cacactctct tagtgaacct
    14281 atgtccacta ttgcaaaatc atatgcttat aattagtgtt tgaaatgacg tacgcctgtg
    14341 aataccatag cgattccgta ttcatttgcc attttgatcg attcttcatc tttgattgat
    14401 ccacctggtt gaataatagc tttgatccct gctttggctg ctaattcaac cgtatcgccc
    14461 attgggaaaa aggcatctga tgccaaaatc gctccgtttg ctttgtctcc tgcttgttcg
    14521 attgcaattt tggctgctcc gacacgattc atctgccctg cacctacacc tacagtcata
    14581 tcatcggctg ctagtacgat tgcattggat tttacatgtt tgacaacttt ccatccgaat
    14641 aacaattgtt ttaattcttc gccagaagga gagcggtcag tcacgacttt tagatcgtct
    14701 gttgtaatcg aatgcacatc gctttcttgt accaccatac cgccttcaat cgtagttacc
    14761 acatgctgtg ctgtacgttc ttccgatgaa gtcagttcac ccattttgag caaacgaata
    14821 tttttctttt tcgtcaaaat ttctaacgct tccgatgtaa agtcaggtgc taatacgatc
    14881 tctaagaaaa tttcgcttaa aggttgcgct gttgctgcat caattgtacg atttgctgct
    14941 acaattccac cgaaaataga ggttggatct gcattgtatg ctttgttgta tgcttcagcg
    15001 atcgtctcgc ctacaccgac tccgcacgga ttcatatgtt tgacagccac gacagcaggc
    15061 tctgtaaatt cttttacaat ttgtaaagct gcatttgcat cgttgatatt gttataagat
    15121 agttctttac catgtaattg ttcagccgtt gttaatgtgc ctgctggagc cattggttta
    15181 cgataaaatg ccgccgcttg atgcggattt tcaccataac gaagatcttg aattttctca
    15241 taagtgaccg tataacgctc tggcaaagga tcacccaaaa cttcacataa gtaatcagaa
    15301 atcaatgcat cgtaagccgc tgtatgacgg aatactttag ccgctagacg tttacgtgta
    15361 tccaacgttg tatcgccttc tgcacgtact tcttctaata ctttggcata atcgctagaa
    15421 tcaacgacta cactaacaaa tgcatgattt ttagctgcac tgcgtagcat tgtcggccca
    15481 ccgatatcaa tattttcgat cgcatcttca tatgcaacgt ctggtttgga gatcgtttct
    15541 tggaaaggat ataaattaac aacaacaagg tcgatatatc ctagttccaa atctttcatt
    15601 tgttgctggt gttctgcgct atctcgaacc gccaacagac cactatgtac tgccggatgt
    15661 aacgttttga cacgaccatc tagaatctct ggaaatccag taacatctga aattccaata
    15721 accggtacac ctgcttcagc aagtagattt ttagtaccac ctgtcgaaat aatttctaca
    15781 cccaattgag acaactcgcg gcaaaaatca accacacctg ctttgtcgga cacgctcact
    15841 agcgctcttt tgatactcat gatgaattta ttcctccttc aattttaaaa agaatttaag
    15901 cttccacaat cacctgtcgt ccttcaagtg ttacttttcc tttagcaatc tgagctacaa
    15961 cctgcggata caatttccgt tcgatatcat ggatccgctc tgctaatgtc tctgctgtat
    16021 cttgttgctg tacttcgatc gattgttgcg caataatcgg ccctgtatcc ataccattat
    16081 cgacaaaatg taccgtaatc cctgttactt tcacaccata agataacgcc tgacctaacg
    16141 catcttttcc tggaaaagca ggcaataacg atggatgtac attaatcatc cgacccatat
    16201 atggatctac aatggttggc gtaagtaggc gcatatatcc tgctaacaca atcagatcaa
    16261 tctcgcggcg ttgcaattct gctacgattt ccagttcata ttgttcacga ctgctatatt
    16321 ctttgggatg aaatacatac gtatctacac ctgcctgaat cgcacgctga actacaggag
    16381 cctgcggctt atcagatact aacaattcga tcgtagtcgc atctggttta ccgaaatatc
    16441 catcttgcca tgcatcgacc atcgcttgaa aattagtgcc ttcgcctgaa gcgaacacag
    16501 caattcgaaa aggcttcatt acacatcgac tccggtaaat gttaccactt tatttccttc
    16561 ttgcaccgta cctatttgat acgccgtttc gccttgttct gctagtaatg tcaacgcttg
    16621 ttctgcttga tccgcaggaa ccacaatgac cataccgatt cccatgttga acgtagtaaa
    16681 catatcttta tggctgatac cgcctttagc ttgcatcaat tggaaaatcg gcaaaatcgg
    16741 ccagtttccg tactcgatat ctacatttac atgttcaggc aacatccgcg gaatattttc
    16801 gataaatccg ccgcctgtaa tatgtgccat tcctttgact ttaacggctt cttgtagcgc
    16861 aagtgtagac ttaacataaa ttttagtagg ctctagcaat acatcaccta gcacggcatt
    16921 acccagttct gttacggtgt ctttgagatc atatccagca tcttcaagca ataatttacg
    16981 tactagtgaa aatccattac tgtgaatacc acttgaagct agtcctagca ctacatcacc
    17041 tgctgcaatt tcactgcctg taatcacttt agctttatct acgataccta ctgtaaatcc
    17101 agcaatatca tattcgcctt cggaatacat cccaggcatt tcagccgtct cgccaccgat
    17161 caacgcgcat cctgcttgac gacaaccatc tgcaataccg gatacgatcg cttcaatctt
    17221 ttcaggaatg acacgatcac atgctagata atcaaggaaa aataacggtt ctgcaccttg
    17281 tactacaata tcgttcacac acatcgcaac agcatcaata ccgattgtat cgtgcttatc
    17341 catcgcaaat gctagcttca gcttcgtacc gacaccatct gtaccggata cgagtacagg
    17401 ctcatcgtat ttatctttgt tcaggccaaa caatgcaccg aaaccaccaa gttctgtcat
    17461 cacttccggg cgaaacgttg ttttaacgtg ctttttcata cgttctactg cttcattccc
    17521 tgccgcgata tcgaccccgg cacttttata ggcttctgac actgtacatc gcacctttcg
    17581 tttgggctta ggaaatgggg tgtggtagaa agaggttggg agctacagcg ctgcgaggaa
    17641 aaggttgttc tgtcgtcgct gttaaggttg gatatcttga tggactgctg ggcagtcgat
    17701 atccaacctt aaaggcgagc gcttcgctct ttcgaacaat ccttttcctc tccgcttgag
    17761 cgtggttcaa cttttctaaa gcacacccta attctctaag gttgttttgg tagtctagtt
    17821 ggtgaggctc tacttcgtaa tcgctggttg tattggatat tagttcgtat tgattctgtg
    17881 gggcttgctc tttgctcttt gctgactaat ttttattttt ttataaagat aaatttatat
    17941 ttttttataa attgctatct atagtaggaa cttatattca tttttttaga gaatatatca
    18001 ctattcaaaa tggatttcac gatacccaat aaaaatggaa cgaatactca gagtaaacaa
    18061 atacttttca tgcaattcaa aagcatagtt tccttaaagg ttctacttca tcatccccaa
    18121 ataatactga atataattcc atccaaaatg cctagaactc tataacacta tacctatcat
    18181 acaaatagat atcttcctta aatacatcat tctaaacgtc aagaagttcc aaaaatccct
    18241 actgtgagga cgacaggaca atacagtgct ctaccatcct tctacactcc cactaaaaga
    18301 gagcatgaaa gcccactgct ttagatcatt ctgatctacc ctgccacccc aattagatcg
    18361 aactttatat cactctggaa tggtggcttt tgagcggcgg agcgacggga caggaatgaa
    18421 tctgtgagaa gcgtagcgtt cgcctttgta gatggatttt aaccgcacag cggttgttca
    18481 aaaaatccag ctacaacaag cgatcgggaa gatcattcct gtcccatagc ggtcccccac
    18541 tcaaacgccc gccacctttt ccaagataca aagccttcga ctaacaccca catccgaatt
    18601 gctcttcgcc gccgaagtcg gtttgtgttg gatagtcgtt gtcgaagcat gccatacaca
    18661 tgccaccttt gtagtctgtg ctgttgtcgc caccgacagc tttgattaat ccttcaaagc
    18721 tcaaaaaggt gagtgaatca gcatttagtt ctttgcgcat ttcttcaatc gacatggttg
    18781 atgcgatcaa ttcgcgtcga tccggtgtat caataccgta gaagcatgga tttttaaaag
    18841 gaggcgatgt aatccgtaca tgtacttctg tcgctcctgc atcacgtaac atattcacga
    18901 ttcggcgtga tgttgttcca cgtacaatcg aatcatcgat catgacgaca cgtttacctt
    18961 ccaccacgcg gcgtaccgca ctgagtttca ttttcacacc ttgctcacgt agttcctgac
    19021 tcggttggat aaatgtacgc ccggtatatt tatttttgat catcccaagt tcataaggga
    19081 tacccgtttg ttcagcaaat ccgatcgctg ctgaaatact ggaatccggt acacctgtca
    19141 ctagatccgc atcgataaat gattcctgtg ccatcaccga acccatccgt ttgcgagccg
    19201 catgtagatt ggcaccattc atatcactat ctggtcttgc aaaataaata tattccatcg
    19261 aacaaagcgc tttacgttgc ggttcgatat aacgatcttc gatcaaacca tgttgatcca
    19321 aaatcagtaa ttctcctggt tgaacatctc gtactaactc tgctccgatc gtttcaagag
    19381 cacaggtctc tgaagcaaaa atatacgctt cacccagacg acccatcgtg atcggacgca
    19441 atccgttagg atcagaagcc actattaatt gctcattggt cataatcata aaagcaaaac
    19501 cgcctacaat ttgtcggaac gcatcttttg ctgcttcgac tagaggctta tttgaacgtg
    19561 cgattaagtg agcaaccact tctgtatcac tggtcgtttg gaaaatagaa cccgcttctt
    19621 ccaattcacg ccgaatctgt ggtgcattga cgatattacc gttggttgcc agtgctaatt
    19681 cacctgcacg ataacggaat accaatggtt gtgcattggt cagacgacta tctccactgg
    19741 tggaataacg aacatgacca atcgaaatat cacctgttaa tgaacctaat gtatctttat
    19801 caaaaacttc tttgaccaga cccatacccc gatggtaatg aaactggttg cgatcactta
    19861 cacacaagcc tgcgctttct tcaccacgat gttgaagcgc atgtaatcca taataagaaa
    19921 gggaagcggc ttccgaatgt ccgtagactc cgaaaacgcc gcattcttct tttaacgtat
    19981 caaaaatatc attgggaccg gtgccttgat tgtagtaatc acctgtccat aacgtctgtt
    20041 tgtttaattc atcagacatg gaatcgcatc ctcccagact tgacgcagat tgttcacctg
    20101 ctctgccaag acttgtttgc cgtccacttg gatttgaagt tctgttcctt gcacttgacc
    20161 gatacgacgt acaggcacac cttgagattg aatatgactt tccaacgcat ctgcttgcgc
    20221 aggagtcgct gataacaaaa tacgagattg gctttcgctg aataacaata gatcatgacg
    20281 caagttgtcg ctgctcagtg ccacgcttgc acctaattta ccactaatac aagattctgc
    20341 taaagctaca gacaatccac cttcagatag atcatgtgca gattgtacta gtccgctttg
    20401 aatggcgctc agtacgctac ctagcaattt cttttcaatc tccaaatcta atgctggtgg
    20461 gcgaccttct gtcacattgt gcacgacttt ctggaattca ctaccaccta gttcggcaaa
    20521 tgtatctcct aatacgaaaa taatatcgcc ttcgtttttg aaaccttgcg ttgtaatatg
    20581 atctgtatcg tgtaccaatc caaccatacc cacaactggt gtaggataga tcgctccacg
    20641 tgtattttca ttataaagac taacattacc accgattact ggagtatcca gtacacgaca
    20701 agcttctgcc ataccatcta ctgatttttc catttgccag aaaatatctg gtttttccgg
    20761 gctaccaaaa ttcaagttat ctgtgatcgc aagcggttct gcaccggagc agacaatatt
    20821 acgagccgct tcgctgacag caattttgcc ccctacttct ggatcaagat atacataacg
    20881 tccattacaa tctgtagtca tagccagtgc tttgcgtgta ccacgaatcg taatgactgc
    20941 tgcatctgaa cccggacgaa ccgctgtact cgtacgaacc atataatcat attgatcata
    21001 gacccatgct ttgctcgcta ctgttggtga agcaagaatc gattttaacg caccactgag
    21061 atctgtaact tcatcataac gattggtatc gacattcgct tgttgctcat aataagcagg
    21121 tactgaagaa ggcttatcat agatcgggca ctcatctaca agcgcatgta caggcatatc
    21181 gccaaccact tcgccatgat gtaataattt caagcgtcca tcatctgtca ctttaccaac
    21241 tttggcacaa attacgcccc aacgttcaaa gatttccatc gcttgcgctt cgtcttttgg
    21301 ctctactacg aacaacatcc gttcttgaga ttccgaaagc atcatttcat aagctgtcat
    21361 gccatcttca cgttgaggga cttgatcaag atacaattct agaccgttac ctgctttact
    21421 tgccatctct gcactagaac atgttaagcc agccgcaccc atatcttgaa tccccagaac
    21481 aataccagaa tcaatcaatt ccaagcaaga ttccatgaca agcttctcca taaatggatc
    21541 gccaacttgt actgcggtac gacgtgcttc tgattcttct gttaattctt ctgatgcaaa
    21601 tgtagcgcca tgaatcccgt cgcgtcctgt aggaggtcct acataaaata ccggattacc
    21661 tactccttta gcgacaccac gttggatttt gtcatgatcg atcaatccga cacacattgc
    21721 attaaccagt ggatttccgt cataactttc atcgaacatc acttcgccgc caaccgtagg
    21781 aatcccgata cagttaccgt aacctgcaat cccggatacc acatgctcga acaaatattt
    21841 cacacgttca ctttcgagct taccgaagcg taaagaattc aatactgcta caggtcgtgc
    21901 tcccatagag aaaatatcgc ggataatccc gcctacacct gttgctgctc cttgaaaagg
    21961 ttctaccgca gatggatgat tatgactttc aattttgaaa acaaccgctt gattatcacc
    22021 aatatctaca atccctgcac cttcacccgg tcccattaat acacgaggac cagaagttgg
    22081 gaagcgacga agtaacggtt tggagttttt gtatgcgcag tgttccgacc acattacact
    22141 aaatacgccg atttctgtgt agttcggttt ccgtccgaga aaaccgcaga tcaactcata
    22201 ctcgctgtcc gatacaccca tttgtttgta tatttgctgg tctgcgactt gctccgccgt
    22261 cggttcctta acggatgttt gctgcatcat gttgatccct ccaagctttc aaaatagatg
    22321 taaacatttt tttaccatct gctgatccta acaattcatc cactgcacgt tcagggtgag
    22381 gcatcatacc tacaacattt ccacgttcat tacaaatccc tgcaatatca tgtagtgatc
    22441 cattcggatt atgtccgtac tggaacacga tctgattgtt cgct
//
