LOCUS       NZ_CP117713            11723 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 plasmid unnamed4, complete sequence.
ACCESSION   NZ_CP117713
VERSION     NZ_CP117713.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 14055)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14055)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2332
            Orig. end                         :: 14055
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117713.1.
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11723
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..11723
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11723
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:>11723](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..>11723
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(24..38)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    149..164
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(1108..3732)
                     /gene="rph"
                     /locus_tag="PSQ21_RS37765"
     CDS             complement(1108..3732)
                     /EC_number="2.7.9.6"
                     /codon_start=1
                     /gene="rph"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971269.1"
                     /locus_tag="PSQ21_RS37765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="rifamycin-inactivating phosphotransferase"
                     /protein_id="WP_274036781.1"
                     /sec_met_domain="PPDK_N (E-value: 6.6e-90, bitscore: 291.0,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASYVLDLKEVDERCVAAVGGKGAHLGGLSRLEGVRVPEGFCVT
                     TDAFRRAMTKVPSIGGRLDELARLSPDDREAIRTLSAQMRGIIEDLAVPGDLAETVTGA
                     LARYGEHAAYAVRSSATAEDLPTASFAGQQDTYLNVLGAAAVLQHISRCWASMFTERAV
                     IYRQRNGIDHRTVHMAVVVQRMVFPQASGVLFTADPVTGNRKVATVEAGFGLGEALVSG
                     LVNPDVFTVRDGEVVTRAIAVKERAVHAVPAGGTCDVAVDARQRERPALTDEQAVSLVG
                     LGRRIEAYFGRPQDIEWCLVDDGFRIVQSRPVTTLFPLPVIDNGEEGKDGGNHVYVSVG
                     HQQMMTDPMKPLGFSMWQLTAMVPMHEAGGRLFVDVTRRLASPAGRDALLEAMGKGDPL
                     VRDALETVLEREGFVPLLPDAAPGGPPPTGAPAPIDTDPAVVTELIEYSRTSIAALERD
                     IRTKKGPALFDFLLEAFEEHKRVLADPLSMQAIMAGMDATWWLNDRLWEWLGEKNAADT
                     LTLSAPGNITSEMGLALLDVADVIRPLPEVLAFLRDAGHLEDATFLDELAKTEGGDEAR
                     EAIEAYLDRYGMRCVGEIDITRPRWRERPTMLVPVILDNVRNFRPGAAERRFEQGRRKA
                     GEKERDVLSRLRALPDGDRKADETQRMIERVRTFIGYREYPKYGIVCRYFVYKRALLAE
                     AERLVRDHVLPEKEDAFYLTFQELHEAVRSNRADEQLIQRRKEAFWSYHALTPPRVLTS
                     EGEAVTGAYRRDDVPAGALTGLPVSAGTVEGRARVVLDMAEADLEAGDILVTAFTDPSW
                     SPLFVGIAGLVTEVGGLMTHGAVIAREYGLPAVVGVEQATRLIRDGQRIRVHGIDGYVE
                     LLP"
     gene            complement(4097..4812)
                     /locus_tag="PSQ21_RS37770"
                     /pseudo=""
     CDS             complement(4097..4812)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060322.1"
                     /locus_tag="PSQ21_RS37770"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="response regulator transcription factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDSEREPVRVVIVVGGQLVRMVLRLVSTAKADRV"
     gene            5367..6023
                     /locus_tag="PSQ21_RS37775"
     CDS             5367..6023
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382336.1"
                     /locus_tag="PSQ21_RS37775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5701 family protein"
                     /protein_id="WP_274028209.1"
                     /transl_table=11
                     /translation="MPNASTADPAHALPSPADQARRLIELGVHEIAGIPAEDIHAFAET
                     ADPGRDILLAVHPDHAPASTLAPLLLRDGKPGFVVVDMPDVDQFTPNTAELPDTPLYFI
                     TGPDRGDHMSNWSPEEALPAFTQQGRTPLVLTEGIHWVLQQPAVLQRNLCFMTIGSRLR
                     KANGTLDARTPAIWISNGTGRDSRERRNAPKIGWCWWGNRHTWLGFASATSRERQ"
     misc_feature    complement(6298..6315)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.82"
                     /tool="antismash"
     misc_feature    6516..6531
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.0"
                     /tool="antismash"
     misc_feature    complement(6518..6531)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.54"
                     /tool="antismash"
     gene            6850..7050
                     /locus_tag="PSQ21_RS37780"
     CDS             6850..7050
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512746.1"
                     /locus_tag="PSQ21_RS37780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_274036778.1"
                     /transl_table=11
                     /translation="MSLPEMATAFDLSALDLGEITVTAMRDTAGIAESTYSLSSSSSTS
                     CQGCSGCSACSVQPPQQPNTA"
     gene            7188..10004
                     /locus_tag="PSQ21_RS37785"
     CDS             7188..10004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487809.1"
                     /locus_tag="PSQ21_RS37785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274036779.1"
                     /transl_table=11
                     /translation="MNPPVPELQTPAAPALDGHTSPLPRIAPGALVRTTLLSLPAEPAP
                     AAAFRAALAELVVLEGRLTALAPALGDALYASRADHTEEYHREVVLPLRRAVHNGRAPR
                     PALLRRLEGLPDRLPELRAWLTARRRREELLTALRAGAGPALSAGRSVLAGLCREPSFL
                     RAASFTSADLLRAVVRAGQGREDRRTRKEEPGVLRHVTRAVARTTPLSAFVGVGWGVLP
                     TPPGAKREAGPGDGPEQGTGSWHGPEQGTGVWNGADLPIGSSRAVVRANRTLVDTLFAA
                     LAEDPRRRSTLPHRMCSSLRLSDGRAAFARSRTAFTAARFLAVEDDEVTLGAVQPLRRL
                     AALCDPPATLDALAAMLAAEGATDAEPAQVDAASAFVGQVRDAGLLVAVEPFDPQDPDP
                     LPRLARWLRGTGSPQDHELALRIDDLFLVTGEFGTAEPGRRAALLATLRDRWVTLLDEV
                     GRPVGPDPTRLTVLSEDVVMRQPVGLDGFLGDRDHRAISELAILAEVFDLGPVVRRQVR
                     DSFVARYGPGGVCPHVWDFGADANEAWQRAARTFGEGAPGADGDGSTAAGGIRRLAALR
                     AELVEAVHRAHARSGGGPGDDVVLPAGLVAALGSRLPPWATRRPVSYTEFLQRAPGGEL
                     CVNHVYGGWGRFSSRFLDSVDAGAARGTAAAVSDALGPGAAVAQVRPVSGFNANLHPLF
                     VPREIGPDRSYTSLGADDVELVHDLADDEVRVRIKVTGERADVLYAGVFAPLLLQPRLA
                     PLLMDHPHGITDFSALVPRHRTAVPGGELVRTPRLRHRHLVLRRRRWELAGSTVTVLLA
                     ELAAEGEIPVGTVARWRALLGVPDQLYLRATPPSGSGRVDEDLLRALDRPKPQYVDLGD
                     ALHLRCLGKWLGRHPRGVVLEEALPVPARDEKSAAVELVVETYRAGRPLGDAGDRAPAG
                     HANRREDR"
     gene            10001..>11723
                     /locus_tag="PSQ21_RS37790"
     CDS             10001..>11723
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512748.1"
                     /locus_tag="PSQ21_RS37790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274036780.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 3.5e-12,
                     bitscore: 35.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDQSAYGTATSPRRERPAPDALDSLGRWTLRPGVSVTVLHNGV
                     HLRGWINSLTLEGGPGLPLLWDHLARALAPDGNAAPVPAAPAGSPLRAALLTVVGQLHD
                     HDLLVERPAGGMADGAAQWLGAVADRPAAAAAALARGRAQVLAAPADSPLARTAAQALD
                     RAGIRAQVVETAQLPHGQVLLVASGHREPPDSAQERGPAEMAVALGVRAGIGFVTPVGS
                     TDQARADADALASRLRRREVPGAAGHPALPALLASSAAQRLVCAVAGLRDPSAEAGDAR
                     LLPGLPMALIAEQEPLRGEYRSWPGPVLIDTDRALPPAAVLTLAESLARVAVLTDSRTG
                     VLEEPVPGALPQLPAALVHCPAEEGTLVSGSARADLARLEAVCRAAELRLGNGERGLVV
                     GAGTEHARGRALRRAVTGQGPGAAGRTGGENTPPSSRSEAAAAPDADHPVTGPWSPAAA
                     RHPQAAHWWSVLVHRLGVEATVTVSRLGSGGRPVFLARVHGRTTAEPASGPLGTAVEAT
                     AEDAVAFAALSAVVGAQSATAAAHAHHLVTPSGASAALARTGEQAPWEDTGWTSAWL"
     aSDomain        10085..10327
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PSQ21_RS37790_Thiopeptide_F_RRE.1"
                     /evalue="9.90E-12"
                     /identifier="RREFam004.1"
                     /label="PSQ21_RS37790"
                     /locus_tag="PSQ21_RS37790"
                     /protein_end="109"
                     /protein_start="28"
                     /score="35.7"
                     /tool="antismash"
                     /translation="RWTLRPGVSVTVLHNGVHLRGWINSLTLEGGPGLPLLWDHLARAL
                     APDGNAAPVPAAPAGSPLRAALLTVVGQLHDHDLLV"
     misc_feature    10709..10711
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gaagacgaag gcgatgaccg cgttggccga gatggtccgc cgcatggcgc gtgaggtcac
       61 gttgacgtcg gtggtgccga aggtcgtcat gaccgccacg gcgaagtaga catagtcggc
      121 ccagaccgcg gcccccgctc cggggaaatc gagtgcctct tcgttctcca ccagattgtc
      181 ggcctggaag gcgacggcga acgccacgac gacgcaggtc caggcgatga cgacgagcga
      241 cagcgacagc agggcgcgag agcccccgcc gaaggtggta ctgaggtggc cgggcagcca
      301 caccaccgcc acggccagcg cagcggctgc aatgaggatg gatgcccccg gcccgggcgc
      361 ggtgcccagg acgtaccgct gcaggaaggt gccacgggcc tcgcggtccg cccaggaacg
      421 gatccgttcc ggtgaggcac gcaggaacgc gatcaacgtg atgcccaggt agggaaccag
      481 gtaggcgaac agcaccagca cgccgacgtc ggaagccgag atccgcacga cactgtcgag
      541 gggcaggacc acagccgcgc tcaccgcgat gagcaggcac accagtgaac gacgtcgttc
      601 ggacagccag gaatccacgg acgggcacct ccgggcgttc acggtgcgga cgcggcgagg
      661 ctagacgaat gaactcccgc cggggccaca agccctcgca acgtccacga ggtggtacca
      721 gctgcccccc gaacggccca ccggcggtcg cccgcggcga cgaaggcccg gtacggatca
      781 cgcttccccg gaccggcccg acggcggtcg tacaccagga acacgcggcg cggtccggcc
      841 cgacggcggt cgtacaccag gaacacgcgg cgcggtccgg cccggagtcc cccccttcct
      901 tccccgaacc gcacccgggc ggggcaggag ctgcccaggt acagatcgat cggcctctcc
      961 gccctcggcc gcgctcagcc tgacccccac cggaccggcc aggaaagcac cggccccggc
     1021 ccggcgggcc gttcccgagc agcagggcca gcccgcccac acccatgcgc gcccagcccg
     1081 ggcacgggat cctcgacggg ggggcggtca gggcagaagc tcgacgtacc cgtcgattcc
     1141 gtgtacgcgg atccgctgcc cgtcccggat cagacgggtg gcctgctcca cgccgacgac
     1201 cgccggcaga ccgtactccc gggcgatcac cgcgccatgg gtcatcagac cgccgacctc
     1261 cgtcaccagg cccgcgattc cgacgaacag cggcgaccag ctggggtccg tgaaggccgt
     1321 gaccaggatg tcgcccgctt ccaggtcagc ctccgccatg tcgaggacga cgcgggccct
     1381 tccctcgacg gtcccggcgg acaccggcag accggtcagc gcgccggccg gcacgtcgtc
     1441 gcgccggtac gcgccggtga cggcctcacc ctccgatgtg aggacccgcg gcggggtgag
     1501 cgcgtgatac gaccaaaacg cctccttgcg ccgctggatg agctgctcgt ccgcccggtt
     1561 ggaccgtacg gcctcgtgga gctcctggaa cgtcaggtag aaggcgtcct ccttctcagg
     1621 aagcacgtgg tcccgcacga gccgctcggc ctccgcgagc agggcacgct tgtagacgaa
     1681 gtagcggcag acgatcccgt acttcgggta ctcccggtag ccgatgaagg tcctgacccg
     1741 ctcgatcatc cgctgcgtct catcggcctt ccggtccccg tccggcaggg cccgcagccg
     1801 tgacagcacg tcccgttcct tctccccggc cttcctccgg ccctgttcga agcgccgctc
     1861 ggcggcgccc gggcggaagt tccgcacgtt gtcgaggatc acgggaacaa gcatggtggg
     1921 gcgctcgcgc catcgtggcc tggtgatgtc gatctcgccg acgcagcgca tgccgtaccg
     1981 gtcgaggtag gcctcgatgg cctcgcgcgc ctcgtccccg ccctcggtct tcgccagctc
     2041 gtccaggaag gtggcgtcct cgaggtgccc ggcgtcccgc aggaacgcca gcacctccgg
     2101 cagcgggcgg atcacgtccg cgacgtcgag aagcgccagc cccatctccg acgtgatgtt
     2161 gccgggggcg gacagtgtca gcgtgtccgc ggcgttcttc tcgcccagcc actcccacag
     2221 cctgtcgttg agccaccatg tggcgtccat ccccgccatg atcgcctgca tgctcagcgg
     2281 atcggcaagt acccgcttgt gctcctcgaa cgcctccagc aggaagtcga acagtgccgg
     2341 acccttcttc gtccggatgt cacgttccag agcggcgatg gacgtccggc tgtactcgat
     2401 cagttccgtg acaacggccg gatcggtgtc gatcggggcg ggcgcacccg tgggcggcgg
     2461 gccgccggga gccgcgtccg ggagcaaggg aacgaagccc tcgcgttcga ggacggtctc
     2521 cagcgcgtcc ctgaccagcg gatcaccctt ccccatggcc tccaggagag catcacggcc
     2581 ggcaggcgat gccagtcgcc gggtgacatc gacgaacagc cgcccacccg cctcgtgcat
     2641 cggcaccatg gccgtcagct gccacatgga gaacccgagg ggcttcatgg ggtcggtcat
     2701 catctgctgg tggccgacag agacgtagac gtggttcccc ccgtccttgc cctcttcgcc
     2761 gttgtcgatg acggggaggg ggaagagggt ggtgaccggc cggctctgga cgatccggaa
     2821 accatcatcg accaggcacc attcgatgtc ctgcgggcgg ccgaagtacg cttcgatccg
     2881 gcggccgagc cccacgaggc tgacggcctg ctcgtccgtc agcgccggcc gctcccgctg
     2941 ccgcgcgtcg accgccacgt cacacgtacc gccggcgggc acggcgtgaa cggcgcgctc
     3001 cttgacggcg atggctctcg tgacgacttc gccgtcccgg accgtgaaga cgtcggggtt
     3061 caccagaccg gagaccagtg cctcgccgag gccgaaaccg gcttccacgg tggcgacctt
     3121 ccggttgccg gtgacggggt cggccgtgaa caggacgccg gacgcctgcg ggaagaccat
     3181 ccgctgaacg accacggcca tgtggaccgt acggtggtcg ataccgttcc gctgtcggta
     3241 gatcacggcc cgctcggtga acatcgaagc ccagcaccgg ctgatgtgct ggaggaccgc
     3301 ggccgccccc aggacgttca gatacgtgtc ctgctggccg gcgaaagagg ccgtgggcag
     3361 gtcctccgcc gtcgcactgg accggacggc gtacgcggcg tgctcgccat accgggcgag
     3421 cgcaccggtg accgtctccg cgaggtcgcc cggaacggcg agatcctcga tgatgccgcg
     3481 catctgtgcg ctgagcgtgc gaatcgcctc ccggtcgtcc gggctcaggc gtgccagctc
     3541 atcgagccga ccgccgatcg acgggacctt tgtcatggcc cgccggaagg cgtccgtcgt
     3601 cacgcagaaa ccctccggca cacgcacgcc ctcgagccgc gacagtccgc ccaggtgcgc
     3661 gcccttgccg ccgacggccg cgacgcacct ctcgtcgacc tctttgagat ccagcacgta
     3721 cgaggccgtc accgcgacac ccccggggcg gtcgtgttcc gtcgcaccgc ggcggccggc
     3781 ccggtctccg ccgccccgcc ctctgccgaa ccccttgtcg ggcacgtact cattcctggt
     3841 tctcttccct ctgacgtcat ggcccggtgg acactcccgg ccgaccggcg cacgtcgtgc
     3901 cccgttccgc aggcgggggc accgacccga ggattctgcg ccgtcacccg gggcttgccg
     3961 caagcccccc ggtaagctat aagttgagag tggcaaggag agggtctctc cttgcctttg
     4021 ttctgccctt ctgtgttttt gtgtttttgc gtttctgcct tcttttttgt cttgctgcgg
     4081 cttccccggg gcgctgtcat tcctccgcgt cgcggaccag caaagcgatc tgtacccggt
     4141 gttctggacc gccggaatgg agaacagacc gccggtgcgc gccttgaccg tcacaacact
     4201 gacgtgcagc ctccgggcaa tctccgcgtt ccccagtccg tccgcgctgg cccgaggcgg
     4261 tctcgcgctc gcgttcggtt cagaggcgac agccgttccc acgcggcccc acggaacgat
     4321 tcccgcgcat gggaggactg cggcccagtg gctgcggcga tcacccgtgc cgcggcggcc
     4381 ggggacagca cggggctccc gcccgccacg gcccgcacgg caccgagaaa ccgcagcggc
     4441 agggtatgtc cttgaggacg aaccccaacg ctccggcccg caggacgccg ggcaccaagc
     4501 cgtcggagcc gaacgtcgcc agcatgagca cccggggcgg caccagccgg gccaggaact
     4561 ccccgggtca cgccgaatcc gccgacgccg ccgaggccgc cgaggccagg catccgtacg
     4621 cccatcagca caacgcccgg ccactgctcg cccgccccga tgaccacggc gttcccgtca
     4681 gcccccctcc gcgacgacag tccacagtca gacccggtcc gccttcgccg tcgatacgag
     4741 ccgcagcacc atccgcacca gttgaccgcc gacgacgatg acgacacgca ccggctcccg
     4801 ctcactgtcc acgcgtgctc tcagctcgcg ggcggggtcc ggccagggca gccgcacact
     4861 gaggacgtag ccgctgtcgg acgcgaggta atgacggagc gctccgccgg ccagcccgac
     4921 ccgttcgatc aggccgagaa gtccgaaccc caaggccact ggccgacggc cggtggccgg
     4981 tggccggtgg ccggcggcag gtggccggcg gcaggtgcgt ggtactcgtg gtggccgggg
     5041 catcgcggac atcgacgcca agccactcac ccgccgctcc tccgagagcg acacggacgg
     5101 gggcacccgg ggcatgtccg gcagcgccgg ccagccctgg accacccggc agcagattca
     5161 ccccacaaca ccggccggcg ctcccctgcg gaacgtccag agcgtcgaac gaacagcaga
     5221 tcatgaacgc acctgccaac gccgccgcaa cagcgcgggg tgcgggtccg acccgaggga
     5281 acgtgacccc gccgggaaca ctccggcgat ctctctcgtt cgacctccgg cccactaccg
     5341 gcgaaacgtg aatccgagga actgccttgc ccaacgcttc cactgccgac cctgcacacg
     5401 cgctcccgtc accagccgac caggcacggc gcctgatcga gctcggagtg cacgagatcg
     5461 cggggatccc cgccgaggac atccacgcgt tcgccgaaac agccgacccg ggccgcgaca
     5521 tactgctcgc cgtccatccc gaccacgccc ccgcctccac cctcgcacca ctactgctac
     5581 gcgacggcaa gcccggcttc gtcgtcgtcg acatgcccga cgtcgaccag ttcaccccca
     5641 acacggccga actccccgac acaccgctct acttcatcac cggacccgac cgcggcgacc
     5701 acatgtccaa ctggagcccg gaggaagcgt tgcccgcctt cacccaacag ggccgcaccc
     5761 ccctggtact caccgagggc atccactggg tcctgcagca accggcggta ctccagcgga
     5821 acctctgctt catgaccatc gggtcccggc tacgcaaagc gaacggcacc ctggacgcgc
     5881 gcaccccggc catctggatc agcaacggca ccgggcgaga cagccgggaa cggcgcaacg
     5941 cacccaagat cggctggtgc tggtggggca accgccacac ctggctggga ttcgcctccg
     6001 ccacaagccg cgaacgtcaa taacaccccc ccccacccca cccccagttc ccctccagca
     6061 ccacaaaaca ccacacccac cagaacccgc ccccgacaac cagacacaga acacacggca
     6121 cagggcacag ggcacacggc acacggcaca cggcacacgg cacacacgaa acaccacacc
     6181 accacacaac cgaacattca cccccacgac accagccaac cccaccgtcg acgacgggct
     6241 cctgagcgtc ggggttgtcg tacggcgggg ggccgggccg actacctcgt gcagcccttc
     6301 actcccggac aacatcgcct cctgccggcg gaagtccgct ccactccttc ggagcgcagc
     6361 caccgctcgt tcgcggccgg gtcggctcgc ggccgtcggc ctggcctgtt ggacggcgac
     6421 ggtagcctgc gggacgcgtg cggcaccgct ccgtctgctc acccgccgcc acggggatag
     6481 cgcggcagat cacctgacag ggcgttgcgg gaatgaaacg taagaattat ctctccgagc
     6541 cccctctctt ggcggcgaac catccggatg aggatcatcc agttacggga ttcacttttc
     6601 gatacgcacc ccgaggagaa aagccgacgt aatcgcaccc gcccaccgtc ggcttttccc
     6661 ggaagttaag gggcggcgtc gccctgtccg caatcccttc ctgacaatcg tccggtaacg
     6721 cgtcttcaag acatttctcc gccgtcgcat tggctgatta agccgtgccc cggtcgccgc
     6781 cctgcggcct acgctgccgg atcggtgcgc ggaagcaccg ttcacaccct cacgactccc
     6841 ggaggacaca tgtcacttcc agagatggcc accgcattcg atctcagtgc gctcgatctc
     6901 ggagagatca ccgtcaccgc catgcgcgac acggcgggga tagccgagtc gacctattcc
     6961 ctgtcgtcct cgtcctcgac gtcctgtcag ggctgctccg gctgcagcgc gtgcagcgtc
     7021 cagccgccgc agcagcccaa caccgcgtga cacagcaacc gtgaaggctt ccgcggcgcc
     7081 gtcggccgtc gtgcggcgcg gcgccgcgga ggcctgttcg cgtacgaacc cggcgcctgc
     7141 ggaccgtgtg ccggggccct gtccaccgcc cagccgactg gaccgatgtg aatccgcccg
     7201 ttcctgaact ccagacaccc gccgccccgg ccctcgacgg gcataccagc cctctgcccc
     7261 ggatcgcccc cggcgcgctg gtccgtacga ccctgctgag cctgcccgcc gagcccgcgc
     7321 ccgctgcggc gttccgcgcc gcgctggccg aactggtggt gctggagggc cggctcacgg
     7381 ccttggcgcc cgcgctcggt gacgcgctgt acgcgagccg ggcggaccat accgaggagt
     7441 accaccgcga ggtggtgctt ccgctccgcc gtgccgtgca caacgggcgc gcccccaggc
     7501 ctgccctgct gcgccgtctg gagggcctgc cggaccggct gcccgaactg cgcgcctggc
     7561 tcacagcgcg ccgccgcagg gaggagctgc tcacagccct gcgggccggg gccggccccg
     7621 ctctcagcgc cgggcggtcg gtgctcgccg ggttgtgccg tgagccctcg ttcctccgtg
     7681 ccgcgtcgtt caccagcgcg gacctgctgc gggcggtggt gcgggccggg caggggcggg
     7741 aggaccgccg gacccggaag gaggagccgg gtgtgctgcg gcacgtgacg cgggctgtgg
     7801 cccgtacgac tccgctgtcc gccttcgtgg gtgtcggctg gggtgtcctg cccacgccgc
     7861 cgggggcgaa gcgggaagcc ggcccggggg acgggccgga gcagggcacg ggttcctggc
     7921 acgggccgga gcagggcacg ggtgtctgga acggcgcgga cctgccgatc ggttcgtccc
     7981 gggccgtcgt ccgcgccaac cggacgctgg tggacacgct cttcgcggcg ctggcagagg
     8041 acccgcgccg tcgctccacc ctgccgcacc gcatgtgcag cagtctccgt ctctccgacg
     8101 ggcgtgccgc cttcgcccgc tcccgcacgg ccttcaccgc cgcgcgtttc ctcgcggtgg
     8161 aggatgacga ggtcaccctc ggtgctgtgc aacccctgcg ccggctcgcc gcgctgtgcg
     8221 accccccggc caccctcgac gccctggccg cgatgctcgc ggcagaagga gcgacggacg
     8281 cggagccggc gcaggtggac gcggcgtccg ccttcgtcgg gcaggtccgg gacgcggggc
     8341 tgctcgtcgc ggtggagccc ttcgacccgc aggacccgga ccccttgccc cggctcgcgc
     8401 gctggctgcg cgggaccggc tcaccgcagg accatgaact ggctctgcgt atcgacgatc
     8461 tgttcctcgt caccggtgag ttcggcacgg cggaacccgg ccgtcgcgcc gccttgctcg
     8521 ccaccctcag ggaccgctgg gtgacgctcc tcgacgaggt gggccgcccc gtgggcccgg
     8581 accccacccg cctcaccgtt ctcagcgagg acgtggtgat gcggcagccg gtcggcctgg
     8641 acggctttct cggcgacagg gaccaccggg cgatcagcga actggccatc ctcgccgagg
     8701 tgttcgacct cggacccgtg gtgcgccggc aggtgcggga cagcttcgtc gcccggtacg
     8761 ggcccggtgg ggtctgcccg cacgtgtggg acttcggcgc ggacgccaac gaggcgtggc
     8821 agcgggccgc gaggaccttc ggcgaaggcg cccccggggc ggacggggac ggatccaccg
     8881 ccgccggcgg catccggcgg ctcgccgcgc tccgggccga gctggtggag gccgtgcacc
     8941 gggcgcacgc ccgcagcggc ggcgggcccg gtgacgacgt cgtcctgccg gccggtctgg
     9001 tggccgcact cggctcccgg ctgccgccgt gggcgacccg gcgcccggtc tcctacacgg
     9061 agttcctcca gcgggcaccc ggcggggagc tgtgcgtgaa ccacgtgtac ggggggtggg
     9121 ggcgcttcag cagcaggttc ctggattccg tggacgccgg ggccgcgcgg ggaacggccg
     9181 ccgccgtgtc cgacgcgctc ggtcccggag ccgcggtggc ccaggtgcgc ccggtcagcg
     9241 gcttcaacgc caacctgcat ccgctgttcg tgccgcggga gatcgggccg gaccgctcgt
     9301 acacctccct cggcgcggac gacgtcgaac tcgtccatga cctggccgac gatgaggtac
     9361 gtgtccggat caaggtcacc ggtgagcggg ccgatgtgct ctacgcgggg gtgttcgccc
     9421 cgctcctgct gcagccgagg ctcgcgcccc tgctgatgga ccacccgcac ggcatcaccg
     9481 acttcagtgc cctggtgccc cgtcaccgca ccgccgtacc cggcggagaa ctggtgcgta
     9541 ccccgcgcct gcgccaccgc catctcgtgc tgcggcgccg ccggtgggag ctggcgggct
     9601 ccacggtgac ggtgctgctc gcggagctcg cggccgaggg tgagataccg gtgggcacgg
     9661 tggcgcgctg gcgggctctg ctcggcgtac cggatcagct ctatctgcgt gccacgccac
     9721 cgtcggggag cgggcgggtg gacgaggatc tcctgcgtgc tctggaccgc cccaagccgc
     9781 agtacgtcga tctcggcgac gctctgcatc tgcgctgcct gggcaagtgg ctgggccgcc
     9841 acccgcgggg cgtggtcctg gaggaggcgc tgcccgtccc cgcccgggac gagaagtcgg
     9901 cggcggtcga gctggtggtg gagacctacc gggccggacg gcccctgggc gacgcgggcg
     9961 accgcgcacc cgccgggcac gcgaaccgaa gggaagaccg atgaccaccg atcagtcggc
    10021 gtacggcacg gccacctccc cccggcggga acggcccgcg ccggacgcgc tggactcact
    10081 ggggcggtgg accttgcgtc cgggagtctc ggtcaccgtg ctccacaacg gcgtacacct
    10141 gcggggctgg atcaacagcc tcaccctgga aggcggcccc gggctgccgt tgctctggga
    10201 ccacctggcc agggccctgg ccccggacgg gaacgcggcc ccggtcccgg cagccccggc
    10261 gggttcgccg ctccgggcgg ccctgctcac ggtggtcggc cagttgcacg accacgacct
    10321 cctggtcgag cgtcccgccg gcgggatggc cgacggagcc gcgcagtggc tcggggcggt
    10381 cgccgaccgg cccgccgcgg cagcggccgc gctcgcccgc ggccgcgcgc aagtcctcgc
    10441 cgcgcccgcg gacagcccgc tcgcacgcac cgccgcacag gcactggacc gggccggtat
    10501 ccgggcccag gtcgtggaga cggcacaact gccgcacggg caggtcctcc ttgtcgcctc
    10561 cggccaccgc gagcccccgg actccgcaca ggagcggggc ccggcggaga tggcggtggc
    10621 cctcggcgta cgggcgggca tcgggttcgt cacccccgtg ggcagcacgg accaggcacg
    10681 ggcggacgcc gacgcgctgg cgagcagatt acgccggcgg gaggttcccg gtgcggccgg
    10741 gcacccggcg ctgcccgcgc tcctggcctc gtccgcggcg cagcggctgg tgtgtgcggt
    10801 ggccgggctc cgcgacccgt cggccgaggc cggcgacgcc cggctccttc ccggactgcc
    10861 gatggcgctc atcgcggaac aggagccgtt gcggggcgag taccggagct ggccggggcc
    10921 cgtgctcatc gacaccgacc gggctcttcc ccctgccgcg gtgcttacgc tggccgagtc
    10981 gctggcccgt gtcgcggtgc tcaccgacag caggaccggg gtactggagg aacccgtccc
    11041 cggggcgctc ccccagctcc ccgcggcgct ggtccactgc ccggcggagg agggcaccct
    11101 ggtgtccggt tccgcccggg cagacctcgc ccggctggaa gcggtctgcc gtgcggccga
    11161 gctccgtctg ggaaacggcg agaggggcct ggtcgtcgga gccggcacgg aacacgcgcg
    11221 cgggcgggcg ttgcggcggg cggtgacagg gcagggcccc ggggccgccg ggcgcaccgg
    11281 cggggagaac acgccgccga gcagtcgctc ggaggcagcc gcagccccgg acgcggacca
    11341 cccggtgacg gggccctgga gccccgcggc cgcacgccat ccccaggcag cgcactggtg
    11401 gtccgttctg gtccaccggc tcggcgtcga ggcaaccgtc acggtctcgc gcctgggctc
    11461 gggcggccgg cccgtgttcc tcgcccgggt ccatgggcgc acgacggcag agcccgcatc
    11521 cggtccgctc ggcacggctg ttgaggcgac ggcggaggac gccgtcgcct tcgccgcgct
    11581 ctccgccgtc gtcggagccc agtcggccac ggccgccgcg cacgcccacc acctggtgac
    11641 acccagcggt gcgtccgcgg cactcgcccg gaccggggaa caggcgccct gggaggacac
    11701 ggggtggacc tcggcgtggc tga
//
