LOCUS       NZ_CP117709            10486 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 chromosome, complete genome.
ACCESSION   NZ_CP117709
VERSION     NZ_CP117709.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8003288)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8003288)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7759923
            Orig. end                         :: 7770409
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117709.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10486
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="35"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10486
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10486
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5486](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5486
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    70..85
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.1"
                     /tool="antismash"
     misc_feature    281..295
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    433..453
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.5"
                     /tool="antismash"
     gene            complement(2103..3335)
                     /locus_tag="PSQ21_RS34285"
     CDS             complement(2103..3335)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964394.1"
                     /locus_tag="PSQ21_RS34285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyl hydrolase"
                     /protein_id="WP_274035311.1"
                     /transl_table=11
                     /translation="MPAKRRLFVSCIAAAVLSLLAGGGIAGQSPPGTDSVDGAAPGPPG
                     AASSTAHGAYLDYGPAGVRRMADLSRWLGGAELRAGHTYLPGDLWVNIEGAPDFLEAWA
                     DWRQADADRMFVLNVPMLERNEERVGDDEVRGLLRAGAAGEYDQHFTRLAERLVGLGVP
                     DTVIVLGWEMNGTTYTHRCGPDPASWKAYWERIVTAMRAVPGQEFRFDFTPSRGRDAVP
                     WTECYPGDDVVDIIGMDSYDQPPGETFDDQITDPYGLQKHVDFAAEHGKPISFPEWGLF
                     RNGDNPEYMRRMLEWIDRHEPLYQTVTDYCPHGVWQCGSNPRSSEVYRTMLTEMAAPAT
                     PGPTPTPTPPAPSPAPSDPTVPPSVVPSPVAPSPTPPGAGAPPTRGWCVPVPFGDWLGP
                     WLREREICFRL"
     gene            complement(3458..4747)
                     /locus_tag="PSQ21_RS34290"
     CDS             complement(3458..4747)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964393.1"
                     /locus_tag="PSQ21_RS34290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_274035312.1"
                     /sec_met_domain="p450 (E-value: 2.4e-19, bitscore: 68.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPYQLSGDRVLRAADVDLADPAFWRLPRPERLRAFALLRELDA
                     PVLFTPRAGAARTAGKPFHALVRHADVRTASRTPQVFASAPGVTTPEPAGWAKALFGNS
                     MVNMDGPEHAALRRIISRRFTPRLLADVEENIGRLAGRLVGELIAERPRDFMPSAASRL
                     PLEVICDLMGVPKAYRARIAEQIDHASEHVGVERRGRARLRIPGRGLASLARMRIVMGR
                     LARERRRHPEDDLVSALVSADIDGEALSGQQLGAFFSLLLVAGVETTRNAIAHGLFLLD
                     RHPEQRELLRSDFDRHIGGAVDEIVRHSTPIIQFRRTVTAECALGGRTFLPGEKVALVY
                     ASANRDEAVFTHPDRFDITRSPNPHLGYGGGGPHHCLGAHLARLEMTALFRELISRRPV
                     MGNLGDPELVDSNFDNRVGSLPFTFGPAFT"
     gene            5001..5486
                     /locus_tag="PSQ21_RS34295"
     CDS             5001..5486
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955806.1"
                     /locus_tag="PSQ21_RS34295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_274035314.1"
                     /sec_met_domain="melC (E-value: 2e-45, bitscore: 153.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTPAQPSVTRTPSRRIVLRGAFTAAVVTGTAGALLPLLDREQA
                     AAARPAPAPGAPGARAVPGPVSTTEQFAEMYRGREIRGATKAVAAASNDDRVMVAAGPG
                     AEIRIDGRPLHVMRRADGTYLSDVRHYESYPTLLETARAAVDELGAAGLAHPAAHRM"
     gene            5506..6369
                     /locus_tag="PSQ21_RS34300"
     CDS             5506..6369
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955807.1"
                     /locus_tag="PSQ21_RS34300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_274035316.1"
                     /transl_table=11
                     /translation="MYTRKNQRDLTRTEKRRLVDAILKLKRSGRYDDFVVMHREYYVMD
                     TERRPRPAHMTSSFFPWHRQYLLEFEKALQAVDAGVSVPYWDWTQDDSPTSSLWAEDFL
                     GGNGRPGDRRVTTGAFAHDTGNWNVGRGVTDERYLTRNFGRPGRNPVSLPTRNDVARAL
                     QDPVYDTEPWNSVCTEGFRNRVEGWGIRGVRTVGLHNRVHQWVGGPMAGAASPEDPVFW
                     LHHSFIDLLWDRWRKAHPKSAYLPGRKPASPGPDRDYVFGLDEAMPPWGVTPRKLLDHS
                     KTYRYA"
     gene            complement(6437..6718)
                     /locus_tag="PSQ21_RS34305"
     CDS             complement(6437..6718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512958.1"
                     /locus_tag="PSQ21_RS34305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_274035317.1"
                     /transl_table=11
                     /translation="MSRITKVAAVMAGTGALIAGGAGMASADAGAQGLAAASPGVASGN
                     VVQVPVHVPVNLCGNTIDVIGVLNPAFGNTCVNADGGHHDNGGYGYGR"
     gene            complement(6859..8010)
                     /locus_tag="PSQ21_RS34310"
     CDS             complement(6859..8010)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955809.1"
                     /locus_tag="PSQ21_RS34310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_274035318.1"
                     /transl_table=11
                     /translation="MTGRRRAGGLVVTLCRDFAEFGALAGEWDALHRRCATATPFQSHA
                     WLHSWWISYGQEGRLRVLLVRRAGRLVGAAPLMLVHRPMPLLVPMGGAVSDFFDILLDE
                     EEAGCAVGALGRGLDRAARHAVVDLREVRPDASAQLLFGRWAGARSRLTDSTCMELPAE
                     PLGDAVARLTGSRGQRLRSKLRKADALGVEALRVPRDGVPAAIATLLRLHERQWEGRAV
                     NPEHLRARFSDHLIRSVGRMVGDGTAAMTEFRLNGEVVASNLSLQSGRLTGGYLYGADP
                     ALRERKVDVSTLLLREVAQQAADSGYEVLSLLRGAERYKNHWQPVPVVNQRLLLARPGL
                     EPLLRLRESQVAVRERAVETVKARFPAARDWRERLTGLPVIGR"
     gene            complement(8007..8681)
                     /locus_tag="PSQ21_RS34315"
     CDS             complement(8007..8681)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377858.1"
                     /locus_tag="PSQ21_RS34315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_274035319.1"
                     /transl_table=11
                     /translation="MTDSPEQQRHVVVRRLRTALARLPHWWPLPVCVLIGTASGLSYSA
                     LAADRYEATSYAMAVAEAGTDPSAALGYAQSYGRLTTSDATLSYARGAAGEPVRELRSH
                     VRSETSPDSPMIAVTGTSGDRRKAADIANAVIEAVIVSSGHVSKDTGVKLIKFSHAMTP
                     DQPVSPSVPLGVSVGAAAGGLLGGLVLLVRPRGAGGSVSARVPGPTAEGGSVAQDDREL
                     VR"
     gene            complement(8678..9814)
                     /locus_tag="PSQ21_RS34320"
     CDS             complement(8678..9814)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487589.1"
                     /locus_tag="PSQ21_RS34320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_274035320.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.4e-20,
                     bitscore: 72.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRALHVITGLGVGGAERQLRLLLRHLPVECDVVTLTNPGAVAGEL
                     RSDGIRVTHLGMRGNRDLSAVGRLARLIRDGRYDVVHTHLYRACVYGRIAARLAGARAT
                     VATEHSLGRAEIEGRPLTRPVRALYLATERLGSATVAVSSTVAGRLRDWGVPADRIRLV
                     PNGIDADRFRFDAGRRASVRAELGLPGEAFVVGGVGRLVPGKRFDVLIRAVAALPEARL
                     LLAGDGPEAGSLRALALRLGAVDRIRFLGECDEHGDGPVPGVPALLSAVDVFVSTSREE
                     SFGLAAVEALAAGLPVLHDACPAIDDLPAAHAPAATRIAGSPEELTARLRQRIQAGADR
                     RPPPRAVGHYDIRRSSERLMDVYAYALDTAPPNRRALS"
     misc_feature    complement(10155..10173)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.61"
                     /tool="antismash"
ORIGIN
        1 tcgatctcca gggactcgaa gggcagcccg ccgagtccca ggggcggccc ggcgggcagg
       61 tccgggaagc tgaccgtgtt gtccggagtg acgaccaccg gcggcgggtg accggcccgc
      121 gccatggtgc aggagccgtt cgccggatcg tagacggcgt acagacaggt ggcccccacc
      181 accgtcgtcc cgccccgctc cgccgggccc cccgcacgct cctcctcgct gagccgcagg
      241 acgagatcgt ccaggcgtgc cagcagttcg tccgggggaa ggtccatgtc ggccagcgtc
      301 tggacggcgg tgcgcagccg gcccatggtc gcggcggccc cgatgccgtg cccgacgaca
      361 tcgccgatga ccaggccgac ccgggctccg gacagcggga tcacatcgaa ccagtcaccg
      421 ccgaccccgt ccttcgcgtc cgccggaaga taggacgacg ccacgtccag cgccgtcccg
      481 ccgcgcagcg tgtgcggcag caggctccgc tggagcacca gcgccgcggt gtgctcccgg
      541 gtgtaacggc gggcgttgtc cacgcacacg gcggcacgcg ccaccagctc ccgggcgggc
      601 gccacgtcgt cctcgtcgaa cggcaccgga ttccgcgacc gcatgaaggt ggtcagcccc
      661 agtacggtgt cgcgcgcccg catcggtacg gagatcagcg agtgcagccc gaactcccgc
      721 agccgggcgg cccgcgcggg ctgctccacc gcccacccgt ggctgtccgg gtcgagcacc
      781 gggagcagga ccgggtcgcc gtccaggagg aagtgcgcgt cgtgcggcgg aggtacgaag
      841 ccgaccgcct ccccgacccg cacgaccgcc tccgggcagc cctcccgcac cgagctcaag
      901 cccgccctgc gcatggccgg ccgctcgccc tcggccggcg cgcccggccg gtcgccgccg
      961 aacggggtct ccaacaggtc gacgaagacg aagtccgcga accggggcac cgcgaagtcg
     1021 gcgagctcct gcgccgtgcg ctgtacgtcc agggtggagc cgatactcgc tccggcctcg
     1081 ttcaccagcg ccagcagccg gcgtgcgttc caccggtcgg tgacctcgag gaccgtgcag
     1141 ccgatgccga tccgccggtc cccggcgtcg gccagcggga agaacgagct cgtgaacgcc
     1201 cgccgacggt gcggatcggc ccagctccag cccaggtact cgtagtccgt gatcgcctcg
     1261 ccggtcgaca ggacctgccg catcagccgt tcgagggacg tcgcgagcgc tccgggcagc
     1321 acctcggccg gccggcgtcc caggcgctgc tcccggggca cgccgccgaa ccgttccagg
     1381 gtgtcgttca gccagagata gcgcaggtcg gggtcgagca ccgccatgcc gaccggcgac
     1441 cgggccagga agctgtcgac cacgggcccg ctcatcgacc agtgcggggt gagccgccgc
     1501 ccggagacca ggaagccctc ccgcccggcg atcaggaacg aggcggtggc ccgcacgtcg
     1561 atctccagcg accggccgtc ccggctccac agggggacca gccccctcca ccccgaaccg
     1621 gcccggcagc gggcggccac ctcggccgtc cgccgggctc cccgggggtc cgccagcaac
     1681 agcgcggcgg accggccgac cacctcggcc gccggatacc cgagcagcgc ctcggcccct
     1741 cgggtccagc cgatgaccgt gccgtccccg gcgatcacgg ccgccgcgtc gtcggtcatg
     1801 cgcgcggctt cccacccgtc cccggagggc agcgggccgg gctccgccgg ggagccctca
     1861 tcggcggacg ccatcgcacc tcaccaccct ctgtaggttt ccatggtcgc gcgtcgcgcc
     1921 ggagcccgcc cggcgcgggg ccggggcggg ctgtccctcg ttcggcggcg tgacggagcg
     1981 ggccgtgtcc gcgttggagg gggagacaag cggccgcttg tccacctgcc cccgcgctgg
     2041 acccgtgtgg gtggacggct ccggctccga caggagggcc ggagccgttt ccatgtccag
     2101 gctcagagac ggaagcagat ctcgcgctcc cgcagccacg ggcccagcca gtcgccgaac
     2161 gggacgggga cgcaccaccc gcgggtgggc ggtgccccgg cccccggcgg tgtgggcgag
     2221 ggagccaccg gggacggcac cacggacggc ggcaccgtcg ggtccgaggg agcgggagag
     2281 ggagcgggcg gcgtcggggt cggggtcggg ccgggcgtgg ccggcgcggc catctcggtc
     2341 agcatcgtcc ggtacacctc cgaggaccgc ggattgctcc cgcactgcca gacgccgtgc
     2401 gggcagtagt ccgtgaccgt ctggtagagc ggctcgtgcc ggtcgatcca ctccagcatc
     2461 cgccgcatgt actcggggtt gtcaccgttg cggaagagcc cccactccgg gaacgagatg
     2521 ggcttgccgt gttccgccgc gaagtcgacg tgcttctgga gcccgtacgg gtcggtgatc
     2581 tggtcgtcga aggtctcgcc gggaggctgg tcgtaggagt ccatcccgat gatgtcgacg
     2641 acgtcgtcgc ccgggtagca ctcggtccac ggcaccgcgt cccgcccccg gctcggcgtg
     2701 aagtcgaagc ggaactcctg accgggcacc gcgcgcatcg ccgtgacgat ccgttcccag
     2761 tacgccttcc aggaggcggg gtcgggaccg caccgatgtg tgtacgtcgt gccgttcatc
     2821 tcccagccga gcacgatcac ggtatcggga acgcccagcc ccaccaggcg ctccgcgagc
     2881 cgcgtgaagt gctggtcgta ttccccggcc gcgcccgccc ggagcaggcc gcggacctcg
     2941 tcgtccccga cccgctcctc gttgcgctcc agcatcggta cgttcaggac gaacatccgg
     3001 tccgcgtccg cctgtctcca gtccgcccag gcttcgagga aatcgggcgc cccctcgatg
     3061 ttcacccaca gatcacccgg caggtacgtg tgtcccgccc gcagctccgc ccctccgagc
     3121 cagcgcgaca ggtcggccat cctgcggacc ccggcgggcc cgtagtccag atacgcgccg
     3181 tgcgcggtgc tgctcgccgc ccccggcggg ccgggggcgg cgccgtcgac ggaatcggtg
     3241 cccggcggcg actgacccgc gatgccgcca cccgccagga ggctgagaac agccgccgcg
     3301 atgcacgata cgaagagacg gcgcttggcc ggcattgctc ctcctggctg cggtgaattc
     3361 cggccggttc ggcctgatag ggagagagtc gcatcatcgt ccaccggggg catgcgcagg
     3421 agtccattta tcctgttcgg tggtgcgggc gcgccgttca ggtgaatgcg gggccgaacg
     3481 tgaacggcag cgagccgaca cggttgtcga aattcgagtc gaccagctcc ggatctccca
     3541 gattccccat gacagggcga cggctgatca gttcccggaa cagggctgtc atttcgaggc
     3601 gagccagatg ggctcccaaa cagtggtgcg ggcccccgcc gccgtatccc agatgcggat
     3661 tcggcgaccg ggtgatatcg aatcgatccg gatgggtgaa aaccgcctcg tcacgattgg
     3721 cggaggcgta gacgagcgcg actttctccc ccgggaggaa cgtgcggcca cccagtgcgc
     3781 attctgcggt gaccgtcctg cggaactgga tgatgggcgt cgaatgccgc acgatctcgt
     3841 cgacggcgcc gccgatgtgg cggtcgaagt cggaccgcag cagctcccgc tgctccgggt
     3901 gccggtcgag caggaacagc ccgtgcgcga tggcgttgcg ggtcgtctcc accccggcca
     3961 ccagcagcag ggagaagaag gccccgagct gctgcccgga cagtgcctcg ccgtcgatgt
     4021 ccgcgctgac gagagccgag acgaggtcgt cctcggggtg acggcgccgt tcccgggcga
     4081 gccgtcccat gacgatccgc atccgggcca gcgatgccag cccgcgaccg ggaatccgca
     4141 gccgggcccg gccccggcgc tcgacgccga cgtgctcgga ggcgtggtcg atctgctccg
     4201 cgatccgcgc ccggtacgcc ttcgggacgc ccatcaggtc gcagatcacc tccagcggca
     4261 gccgcgaggc cgccgaaggc atgaagtccc gggggcgctc ggcgatcagc tcgcccacca
     4321 gccgcccggc gagccggccg atgttctcct cgacgtccgc cagcagccgg ggggtgaacc
     4381 gccgcgagat gatccggcgc agcgccgcgt gctcgggccc gtccatgttg accatcgagt
     4441 tcccgaacag tgccttcgcc cagccggccg gctcgggggt ggtgaccccc ggagcgctcg
     4501 cgaacacctg gggcgtgcgg ctcgcggtcc gtacgtcggc atggcgcacc agcgcgtgga
     4561 acggcttgcc ggcggtgcgc gcggcaccgg cccggggagt gaacaggacc ggtgcgtcca
     4621 gctcccgcag cagggcgaag gccctgagcc tctcggggcg cggcagccgc cagaaggccg
     4681 ggtcggccag gtcgacgtcc gccgcgcgca gcacacggtc cccggacagc tggtacggaa
     4741 cggtcatgcc cttcacctcc acggttcgcc aggccatggt ccggcccacc ggccgcgagg
     4801 cgcctcatcg acgcggcccg ccgccccgac gaccccgcac cctcacgcgt ttgacggaac
     4861 ggaaccaccg ccggtgcgcc gtacgccgca cgcacgagaa ctgtttcgcc cccgcctcgt
     4921 tgtcaacatc gccatcagaa gcacctcgga cgagttaacg aatcaatgag gcgagtcaac
     4981 gagaggcagg tagtcatccc atgagccgaa cccccgcgca accgagcgtc acccgcaccc
     5041 cctcccgccg gatcgtcctg cgcggagcct tcaccgccgc ggtggtcacg ggcacagcgg
     5101 gcgccctgct cccgctgctc gaccgtgagc aggccgccgc ggcccggccc gcaccggcgc
     5161 ccggggcgcc cggagcccgc gccgtgcccg gccccgtgtc cacgacggaa cagttcgccg
     5221 agatgtaccg gggccgggag atccgggggg cgacgaaagc cgtcgccgcc gcctcgaacg
     5281 acgaccgcgt gatggtcgcc gccggaccgg gcgccgagat ccgcatcgac ggcaggccgc
     5341 tgcacgtcat gaggcgggcg gacggcacct atctgagcga cgtccggcac tacgagtcgt
     5401 acccgacgct gctggagaca gcccgtgcag ccgtcgacga gctcggcgcc gccgggctcg
     5461 cgcaccccgc cgcgcaccgc atgtgaacca ggaggagcag caccggtgta cacccgcaag
     5521 aaccagcgcg acctgacgcg caccgagaag cgccgcctcg tcgacgcgat cctgaaactg
     5581 aagcgctcgg gccgctacga cgacttcgtc gtcatgcacc gggagtacta cgtcatggac
     5641 accgagaggc ggccgcgccc ggcgcacatg acgtcctcgt tcttcccctg gcaccgccag
     5701 tacctcctgg agttcgagaa ggcgctccaa gctgtcgacg cgggcgtcag cgtcccgtac
     5761 tgggactgga cccaggacga cagcccgacc tcctcgctct gggcggagga cttcctcggc
     5821 ggcaacggca ggcccggcga ccgccgcgtc accaccggag cgttcgccca cgacacgggc
     5881 aactggaacg tcggcagggg cgtcaccgac gagcgctacc tcacccgcaa cttcggcagg
     5941 cccggccgca acccggtgtc cctccccacc cggaacgatg tggcgcgggc gctccaggac
     6001 cccgtctacg acacggagcc ctggaacagc gtctgcaccg agggcttccg caaccgcgtc
     6061 gagggctggg ggatccgggg cgtgcgcacg gtgggtctcc acaaccgggt ccaccagtgg
     6121 gtcggcggtc cgatggcggg cgccgcctcc cccgaggacc cggtgttctg gctccaccac
     6181 tccttcatcg acctgctgtg ggaccggtgg cgcaaggccc acccgaaatc cgcctacctg
     6241 ccgggccgca agcccgcctc gcccggcccg gaccgcgact acgtcttcgg cctcgacgag
     6301 gcgatgcccc cctggggcgt gaccccgagg aaactcctcg accacagcaa gacctaccgc
     6361 tacgcctgag cccggaacgg ggaacggccg gtcccctccg ggaggagggg accggccgtt
     6421 ccggtactac gcgggatcag cggccgtagc cgtagccgcc gttgtcgtgg tgaccaccgt
     6481 cggcgttgac gcaggtgtta ccgaaggcag ggttcagcac gccgatcacg tcgatcgtgt
     6541 tgccgcagag gttcaccggc acgtgcacgg ggacctggac cacgttgccc gaagcgacgc
     6601 cgggggaggc ggcggcgagg ccctgcgcgc cggcgtccgc ggacgccatg ccggcgccgc
     6661 cggcgatcag ggcgccggtg ccggccatga cagcggcaac cttcgtgata cgagacattc
     6721 ggaactcctt gtaaagaagg gggtgtgctg cggacgcgag gcccgcaccc cctgacaacg
     6781 cggcagacgc cggacggtaa cggatctgct cacaggtggt acctccgatg ccgctgtccg
     6841 gcgtacaccg ggcccgcgtc agcgtccgat caccggcaac cccgtgagcc gctcgcgcca
     6901 gtcccgcgcc gccgggaacc gcgccttcac ggtctccacc gcccgctccc gtacggccac
     6961 ctgcgactcg cgcagccgca gcagcggctc cagacccggc cgggccagca gcagccgctg
     7021 gttgaccacc ggcaccggct gccagtggtt cttgtaacgc tccgcaccgc gcagcaggct
     7081 cagcacctcg tacccgctgt ccgcggcctg ctgggcgacc tcgcgcagca gcagcgtcga
     7141 cacatcgacc ttccgttcgc gcagcgccgg atccgcaccg tacagatagc cgcccgtcag
     7201 ccgcccggac tgcaacgaca ggttggacgc caccacctcg ccgttcaacc ggaactcggt
     7261 catggccgcc gtaccgtccc ccaccatccg tcccaccgac cggatcagat ggtccgagaa
     7321 ccgcgcccgg agatgctcgg ggttgaccgc ccggccctcc cactgccgct cgtgcagccg
     7381 cagcaacgtg gcgatcgccg cgggcacccc gtcccgcggg actcggagag cctcgacgcc
     7441 cagggcgtcg gccttgcgca gcttggagcg cagccgctga ccccgcgagc ccgtcagccg
     7501 cgccacggcg tcgcccagcg gctcggccgg cagttccatg cacgtcgagt ccgtgagccg
     7561 gctccgggcc ccggcccacc gcccgaacag caactgcgcc gacgcgtccg gtctgacctc
     7621 ccgcaggtcc accacggcgt gccgggccgc ccggtccaga ccgcgcccca gcgcccccac
     7681 cgcgcacccg gcctcctcct cgtccagcag gatgtcgaag aagtcggaga ccgccccgcc
     7741 catcgggacc agcagcggca tcggacggtg taccagcatc agcggcgccg ccccgaccag
     7801 ccgccccgcc cggcggacca gcagcacccg cagccggccc tcctggccgt aggagatcca
     7861 ccacgagtgc agccaggcat ggctctggaa cggggtcgcg gtggcgcagc ggcggtgcag
     7921 cgcgtcccac tccccggcga gcgcgccgaa ctccgcgaaa tcccggcaca gcgtcacgac
     7981 gagcccgccc gcccgccgcc gccccgtcat cggacgagct cccggtcgtc ctgggcgacg
     8041 ctgccgccct cggccgtcgg accgggaacc cgcgccgaga cgctcccgcc cgccccgcgc
     8101 gggcgcacca gcagcacgag gccgcccagc agcccgcccg cggcggcccc gacggagacg
     8161 cccagtggca cggacggcga gaccggctgg tccggcgtca tcgcatggga gaacttgatc
     8221 agcttcaccc cggtgtcctt ggagacatga ccactgctca cgatgacggc ctcgatgacc
     8281 gcgttggcga tgtcggccgc cttccgccgg tccccggacg tgcccgtcac cgcgatcatc
     8341 ggtgagtcgg gagaggtctc cgaccggacg tgggaccgca gctcgcgcac cggctcgccc
     8401 gccgcgcccc gggcgtacga gagcgtcgcg tcgctcgtcg tcagccgccc gtacgactgg
     8461 gcgtacccca gggccgccga gggatccgtc cccgcctcgg cgaccgccat cgcataactg
     8521 gtggcctcgt accggtccgc ggccagcgca ctgtacgaga gcccggacgc ggtgccgatc
     8581 agcacacaga cgggcagcgg ccaccaatga ggcagccggg cgagcgcggt gcgcagccga
     8641 cggacgacga cgtgtcgctg ctgctcgggt gagtcggtca tgaaagggct ctccggttcg
     8701 gtggggcggt gtcgagggcg tacgcgtaca cgtccatcag gcgctcgctg ctgcgcctga
     8761 tgtcgtaatg gccgacggcc cggggcggcg gcctccggtc cgctccggcc tgtatccgct
     8821 gccgcagccg ggccgtcagc tcctcggggc tcccggcgat ccgggtggcc gcgggggcgt
     8881 gggcggcggg caggtcgtcg atggccgggc aggcgtcgtg gagcaccggc agtccggcgg
     8941 cgagcgcctc cacggcggcg agaccgaagg actcctcgcg ggacgtggag acgaagacgt
     9001 ccacggcgct cagcaacgcc gggacccccg ggaccgggcc gtccccgtgc tcgtcgcact
     9061 ccccgaggaa ccggatccgg tccacggccc ccagccgcag ggccagcgcg cgcagcgacc
     9121 cggcctccgg cccgtccccg gccagcagca gacgggcctc cggcagggcg gcgaccgcgc
     9181 ggatcagcac gtcgaaccgc ttgcccggca ccagccgccc gaccccgccg acgacgaacg
     9241 cctccccggg gaggcccagt tccgcccgta cggaggcccg tcgccccgcg tcgaagcgga
     9301 accggtccgc gtcgatgccg ttcggcacca gccggatccg gtcggcgggc accccccagt
     9361 cccgcagccg gccggccacg gtggaggaga cggcgacggt cgcggacccg aggcgttcgg
     9421 tcgcgaggta gagggcgcgg acgggccggg tgagcgggcg gccctcgatc tcggcacgcc
     9481 ccagggagtg ttcggtcgcg acggtggccc gggccccggc gagccgggcc gcgatcctgc
     9541 cgtacacgca ggcccggtac agatgcgtgt gcaccacgtc gtagcggccg tcccggatca
     9601 gccgggccag ccttccgacg gccgacaggt cccggttgcc gcgcatcccg aggtgggtca
     9661 cccggatccc gtcggaccgc agctccccgg ccaccgcccc cgggttggtg agcgtcacga
     9721 catcgcactc caccggcaga tgacgcagca gcagccgcaa ctgccgctcg gcgccgccga
     9781 ccccgagccc ggtgatgacg tgcagcgccc tcaccgccga ccgcccgtca gcaccggccc
     9841 ggcggcccgg gctgcggcgc ccggcggcgc cacctgccgc agcccgtgcc gcaggtcctt
     9901 cgcccagagg cgcacccccc ggtccgcctg gctgatgtgg gtgcggggga gcgcgaaccg
     9961 gccgagcagc gggccggggg ccagggcgca ggcgtagccg tagcccgccg agcgcgcggc
    10021 ctcggtgacc cggcggtcga ggatgccgta cggatagcag aagccctccg ggagcgaccc
    10081 ggtgagatcg ccgatcagct cccggctgtg ggcggtctcc cggcgcagct cctcgtccgg
    10141 aagggccgtc agatcctggt ggtacagacc gtgcgagccg acctccatgc ccgccgcggc
    10201 gacccgccgg acgtcgtcct gggtgagcag cggcttgcgt gggccgagcg gatcccacgc
    10261 gttgactccg cccggccggc ccggcaggac gaataccgtc gcccggaaac cgtgcccgcg
    10321 cagcaccggc agtgcctcgt cgaggaagtc cgcgtacccg tcgtcgaagg tcagcccgac
    10381 cagcccgcgc cgccccgcgg cccccgcgcg cagcagctcg gacactccca cccccgtcag
    10441 ccgccggctg cgcagccagg acagctgctc gtcgaggcgg tcgggg
//
