LOCUS       NZ_CP117709            11368 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 chromosome, complete genome.
ACCESSION   NZ_CP117709
VERSION     NZ_CP117709.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8003288)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8003288)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7747838
            Orig. end                         :: 7759206
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117709.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="34"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(625..634)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            1239..2069
                     /locus_tag="PSQ21_RS34240"
     CDS             1239..2069
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129276.1"
                     /locus_tag="PSQ21_RS34240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_274036084.1"
                     /transl_table=11
                     /translation="MPGPEVVRAEGLAFGYPGRMVLRGVDLSVRAGELVALIGLNGCGK
                     STFLKLAAGLLAPSGGRVLLGGDDVARLPRRTAARRVALLHQSAPAVPGLTVRQLVRQG
                     RYAARGPLGMLREGDDEVTSRALADVGVTAWADRPVDALSGGERQRVRLAMALAQDARV
                     LFLDEPTTYLDLRHQLEVLQTVVRLRAERRLTVVMVLHDLNHAARFADRIVALREGRVA
                     ADGPPAEVVTRRLLAEVLGVEGRVGIDSEGGWPVCYPDHPLDPLQLLRNENHIH"
     misc_feature    2095..2113
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 19.69"
                     /tool="antismash"
     gene            2140..2274
                     /gene="amiA"
                     /locus_tag="PSQ21_RS34245"
     CDS             2140..2274
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="PSQ21_RS34245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_257139051.1"
                     /transl_table=11
                     /translation="MEQNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADAPAEK"
     misc_feature    complement(2147..2161)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.28"
                     /tool="antismash"
     gene            2402..3385
                     /locus_tag="PSQ21_RS34250"
     CDS             2402..3385
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452727.1"
                     /locus_tag="PSQ21_RS34250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274035303.1"
                     /transl_table=11
                     /translation="MTRSRLAPGTGIVTVPGGAPVLRTSGGEFLRIDTGGVAGEDLVRR
                     LAGEEARDEGAHAAELTRLVEAFEQGGHAVSAPARAPLEGRTVHVLGDPVLTVPVARCA
                     GAEGAEVHRITPDGVAELARAIPDRGAEGRVAVVWCLDSPVPEGLWDAADRLPGRGIAW
                     LRCHREGAHSWTEPLAAAPGDVTSRHIRLRRLAATPAHRELAAYWAGHRTPDTGPHPTE
                     ASAALIAALLTADLIAWAEAEAEAEAEAGVAAEAEAGAGVGAGVAAGAGGGRATVLPVR
                     RRLRRIDLRDLTLTEHPVLPVPDVAPLPAPTPVRARTGARTAEARP"
     gene            3382..5004
                     /locus_tag="PSQ21_RS34255"
     CDS             3382..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377868.1"
                     /locus_tag="PSQ21_RS34255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_274035305.1"
                     /transl_table=11
                     /translation="MNTRTVDVPTPDGAVLATDVCLPDGTRALPAVLIRTPYGRDAHRA
                     ELRGWAAHGFAAVAQDVRGRHGSPGEWHPYRGHERTDGAATVAWMRAQAWSNGEVVAVG
                     ASYAAHCALVTALATPDAAGCDGVPDAVIAAVPALGLAETAREPGGPERLWARAGWWAA
                     HGDRRDSDPDALARALADDPRLLEHLPVARLAERLAESLGRELPSWSGLWAARGRGRLA
                     ALGSNCRLPLLAVGGTRDPFADDTVALWRAWGGPSRLLLGPWGHRLTADPAAPARARVN
                     LGALYVRWARAALAGRLEPTRHGVIALGDSGRWHSTRVRSTPPPALPATPREGPEWRAG
                     PAGEDRPDRPEAESRWAFGSPTGLRLLHGAEFSADPDRPVRSDDLAVPAGGDRADRCLL
                     LSPPLPGPLDLAGAAVARINVTADAPCADWAVRLTALDPSGHADPLAFGIVRRTDPPGE
                     AADITVPLGTLGRRLPAGTRLRAEIAGHHFPAHARNPHTGEDPVTATRLAPSRRTVNPR
                     GSVLHLPVVARRRYVEPAPEICR"
     gene            5001..6368
                     /locus_tag="PSQ21_RS34260"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="PSQ21_RS34260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_274036086.1"
                     /sec_met_domain="YcaO (E-value: 1.8e-44, bitscore: 151.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVLPIEALVDPVSGIIRDVAPVEHPAGAPPRYTAMTADVADAR
                     RLGAWPADRVSLGTTFGDPRGAWIAAVAEAVERYCGNRLPPPGHAQAPRRATAAELTAE
                     GHRVYGPGALPAYAPWQLVRPRFPYAELTPDTPALWTRAAEGGRPCWAPVALTHLNWRQ
                     GELRSLPRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPATVP
                     GLTEDLAGCGLDVHIVEMPSEFAPCVAALVHDPGRGIHAAGFACRYDPAEAARKAVLEA
                     VHTWVFTQGAVDADGWVYRAVEAGMLARGLYLDHRADRRYLDDCGPEFAAVRDLGAHVQ
                     VWLDDRMAPLARRFTEPALGTVPVTAIDPGSRTALDAALAAGGHRVITADLTTEDVAET
                     PLRVARVLVSGLIPNAPAAFGYFGCPRFADAALARGWRTRPPTAPGDFTLAPPPHM"
     gene            6383..7915
                     /locus_tag="PSQ21_RS34265"
     CDS             6383..7915
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964398.1"
                     /locus_tag="PSQ21_RS34265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitroreductase"
                     /protein_id="WP_274035306.1"
                     /transl_table=11
                     /translation="MPDTPARTAAPDPGTHPASGLLRRALADARSSRAPGLAPYVPERP
                     FPWSGPGLPLTGVAFRSGAGPGTGGRAAIDLDRVLRLSLAAPAGTPGRLRPVPSAGALH
                     PVRAHLLIGPRCSLPPGRYAYDPRAHRAHPRGPAPDGAPPGGLVVLTVAASRTVVHYGH
                     RAWPLLLLDTGHAAAALALAGPPAADVRVCLDADADLLSAAAGLPAAPDWPDTWPGTEP
                     ELALAAVRLTPAGVTGDDLGTLAVWACPPRAGTPSPQPGAETAPPGELAATRHLLHHIA
                     RARERPGGTWHPAPRPAPVTDEALATRRSAPPDDLNHPPSEDLLVRLLITARTARPDGP
                     AWTVAVGDDAPALYAKAPGSRGLAVRASGDARPTLARWAAGQQWIGGAGAVLLAHGCPG
                     DAPPAAVRSGHLAAGYAAGAVQIHATALGLRSRPIGSWQRADLGAALGEAPGRDWVMHG
                     LAVGAPPPPGPVVPGFARRPPTPNVPPTPTAPDTATTTPATPAAPPGEEERP"
     gene            7912..9651
                     /locus_tag="PSQ21_RS34270"
     CDS             7912..9651
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="PSQ21_RS34270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_274035307.1"
                     /transl_table=11
                     /translation="MMLHPELLRAANTARRPLGLATALLAAVTATHLAQAVLLALVLAR
                     IARGETATLPPLLAAVIAVVLVRAALGRAQRLTAVTAGAAVRVRLRDTLLERLGALGPT
                     AITGARAGAVRATLVDGVEGVDAYISRYLPQALITCAVPPLLLVAVALVEPYAALALGP
                     ALLLALFGPRWWDRLLARRGKEHWDSYEALAADYLEALQGMPTLRATGAVGRVRERLER
                     RSAALHRTTVAKLRVSLVDTGLTDLAVQGGTAAAVLVACSSAATGRTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAALRTAEAAVPDRGTVAAAWKSAPEVRFEDVR
                     FTHPGSGRPALDGVSFTAAPGRTTAVVGPSGAGKSTLLSLLLRQRDPDSGRLTVAGTAT
                     AAYTLASLRRGIAVVSQDTYLFHATIAENLRIARPAATDEQLRAAARTAGIDQEIARLP
                     DGYATLVGERGATLSGGQRQRLALARALLADAPVLVLDEATSAVDERGQARIVRELAAA
                     GRGRTCIVVAHRLDAVRHADHIVVLDAGRVAATGDHTTLLAGGGVYASLVAAGRTAQEE
                     RAA"
ORIGIN
        1 catcgacacc gtgcccggac cggcccgtcg ggccctgcgc gcgccggggg tccggctggg
       61 cggcctggca ctgctcgtcg ccgcggtggc ctgcgccgac ctgttcgccg gccggggtgt
      121 cacccccgaa ggcgtacgga ccgtgctgct cgggggcggc gacgacccga ccgccgagca
      181 catcgtgctc caactgcggc tgccccggct gctggtggcg ctggtcgccg gagcctgcct
      241 cggggtggcc gggctcgtgc tccagtcggc cctgcgcaat ccgctggccg ggcccgaggt
      301 caccggggtc actcccggcg cggtgctcgg cgcggtcgcc gcgaccggcc tcggcctcgc
      361 gggctgggaa tcccccaccg ccgtggtcgt ggccgcctgc ctcggcggct tcgccggagc
      421 ggggctgctg tggctgctcg ccgggcggga ccgcggcgac ccggaacaga ccgcggtcta
      481 cggggtcctc gtctcggcgg tgctcgccgg gctcaccgcg gtcgtcctcc tggtggcacc
      541 cggcgaactc ggcagcgtcg tccagtggtt gatcggttcc accgagggcc gggtgtggca
      601 gcactggaat ctgctctggc cgtgggccgc cttctggggc gcggcggcct ggctgctcgc
      661 cgggccgctg accctgttgc gctgcggcga cgaacaggcc tccgccgcgg gcctggccac
      721 cggccggggc cggggcgcgg cgctcgtctg cgccgtggcg ctgacggccg gcgccgtgtc
      781 ggccgtggga gcgctcggct tcgtggggct gctggtgccc catctggcgc tggccgtctt
      841 cggggccgac ctgcgcatca cccttccggg tgccgcgctg ctcggcgggg cggtggtgtg
      901 cggggcggac gccgctgccc aagtgctgtc ccggctgctg gccaccgcgc tcgacgcgga
      961 ccggctgacc cttccggtcg gagccctgac cacgtttgtc ggggcgacgc tgctgatggt
     1021 cgtggcgcgg cgacgggcgg acgagcgatg acggagagcg gtacgcggac gggacacgtc
     1081 ggcatcggca tcggcaccga cgtcggcacc ggcatcggca tcgacgttga cggaagtgga
     1141 ggacagcgga tgaggagggt ggcatgccgg aaggcctgac cggacaagtg gaatcgagcc
     1201 cggcggaggc ggccgggccg gaagcggaac cgtacgtcat gcccggcccg gaggtcgtcc
     1261 gggcggaggg gctggccttc ggctaccccg gacggatggt tctgcgcggg gtggacctga
     1321 gtgtccgggc cggcgagctg gtcgccctga tcgggctgaa cggctgcggc aagagcacct
     1381 tcctcaagct ggccgccggg ctgctcgccc cgagcggcgg gcgcgtcctg ctcgggggcg
     1441 acgacgtggc gcggctgccc cgccgcaccg ccgcccggcg cgtcgccctg ctccatcagt
     1501 cggcgcccgc cgtaccggga ctgaccgtgc ggcagctggt gcgccagggg cgctatgccg
     1561 cccgggggcc gctcgggatg ctgcgggagg gcgacgacga ggtgacctcg cgggcgctcg
     1621 cggacgtcgg cgtcaccgcc tgggccgacc ggcccgtgga cgcgctgtcc ggaggcgaac
     1681 gccagcgggt ccggctggcc atggcgctgg cccaggacgc ccgcgtgctc ttcctcgacg
     1741 agccgaccac ctatctcgat ctccggcacc agctggaggt gctccagacg gtcgtacggc
     1801 tgcgcgcgga acgccgtctg acggtggtga tggtgctgca cgacctcaac cacgccgcgc
     1861 ggttcgccga tcggatcgtc gccctgcgtg aggggcgcgt cgccgccgac gggcctccgg
     1921 ccgaggtggt cacccggcgt ctgctggccg aagtcctcgg cgtggagggc cgggtgggga
     1981 tcgacagcga gggcggctgg ccggtctgtt acccagatca ccctctcgac ccgctccagc
     2041 tattgcggaa tgaaaatcat attcattagt gtctgtgctg cggcacgcac cgacgccgcg
     2101 aacgacactc atccgaacga ccgaatggag actcaactca tggagcagaa caaggtgttc
     2161 agcccgatcg ccgaccaggg ccagctcgct cacctctccg ccacccactc gaacgccctc
     2221 gtcgagaacc ccttcgacga cgccgtcgag gccgacgccc cggccgagaa gtaagcggct
     2281 cctgccgctg acggcaggtt tcccgcgtag cgcgggggcg ggcccgcccg gtgacctccc
     2341 gggcgggccc gccccgttca gccccgaacg tcccttcccg cttccagctc cggaggaatc
     2401 cgtgacccgc agtcgactcg ctcccggcac cgggatcgtc accgtccccg gtggcgcccc
     2461 cgtgctccgg acctccggag gggagttcct gcgcatcgac accggtggcg tcgccggcga
     2521 ggacctggtg cgtcggctgg cgggggagga ggcgcgggac gagggcgccc acgcggccga
     2581 actcacccga ctcgtcgagg cgttcgagca aggcgggcac gcggtctccg cgccggcccg
     2641 ggccccgctc gaaggccgta ccgtccatgt cctcggcgac cccgtgctca ccgtgccggt
     2701 ggcgcgctgc gccggggccg agggtgcaga ggtccaccgg atcaccccgg acggcgtggc
     2761 ggagctcgcc cgggcgatcc cggaccgcgg cgccgaaggg cgcgtcgccg tggtgtggtg
     2821 cctcgactcg cccgtgcccg agggtctctg ggacgcggcg gaccggctgc ccgggcgggg
     2881 catcgcctgg ctgcgctgcc accgtgaggg cgcccacagc tggaccgaac cccttgccgc
     2941 ggccccggga gacgtcacct cccgccacat ccggctccgc aggctcgcgg ccacccccgc
     3001 ccaccgtgaa ctcgccgcgt actgggccgg acaccggacg cccgacaccg ggccgcatcc
     3061 caccgaagcc tcggccgccc tgatcgccgc tctcctcacc gccgatctga tcgcctgggc
     3121 cgaagccgaa gccgaagccg aagccgaagc aggagtggca gccgaagcgg aagccggagc
     3181 cggagttgga gcaggagtgg cagccggagc cgggggaggc cgggcgaccg ttctcccggt
     3241 gcgccgacgg ctgcgccgca tcgacctgcg cgatctcacc ctcaccgagc accccgtgct
     3301 ccccgtcccg gacgtcgcgc ctctgcccgc cccgacgccg gtgcgggcgc gcaccggggc
     3361 ccggaccgcc gaggcacgcc cgtgaacacc cgtacggtgg acgtccccac gccggacgga
     3421 gccgtactcg ccaccgacgt atgcctcccg gacggaaccc gcgctctccc cgccgtcctg
     3481 atcagaaccc cttacgggcg cgacgcccac cgcgccgagc tgcgcggctg ggcggcgcac
     3541 ggtttcgccg ccgtcgccca ggacgtgcgc ggccgccacg gctcaccggg ggagtggcac
     3601 ccctaccggg gccacgagag gacggacggc gcggccaccg tcgcgtggat gcgcgcacag
     3661 gcatggagca acggggaggt cgtcgccgtc ggcgcttcct acgccgcgca ctgcgccctc
     3721 gtcaccgcac tcgccacccc tgacgccgcc gggtgcgacg gcgtccccga cgcggtcatc
     3781 gccgccgtcc ccgcgctcgg gctcgccgag acggcacgcg agcccggggg ccccgagcga
     3841 ctgtgggccc gggccggctg gtgggcggcc cacggcgacc gtcgcgactc cgacccggac
     3901 gcgttggccc gcgccctggc ggacgacccc cgcctgctcg aacatctccc tgttgcccgc
     3961 ctcgccgagc ggctggccga gagcctggga cgcgaactgc cctcctggtc cgggctctgg
     4021 gccgcccgag ggcggggccg gctggccgcg ctgggctcca actgccgcct cccactgctc
     4081 gccgtcggtg gcacccgtga cccgttcgcc gacgacaccg tggccctgtg gcgcgcctgg
     4141 ggcggaccgt cccgcctgct gctcgggccc tggggccacc gcctcaccgc cgacccggcc
     4201 gcaccggccc gcgcacgcgt caacctcggt gcgctgtacg tacggtgggc ccgcgcggcg
     4261 ctcgccgggc gtctggaacc gacgcggcac ggcgtcatcg ccctcggcga cagcggtcgc
     4321 tggcacagca cccgggtgcg aagcactccc ccgccggccc tgcccgccac cccgcgggag
     4381 ggaccggagt ggcgggcagg gccggcgggg gaggaccggc ctgaccggcc ggaggcggag
     4441 tcccgctggg ccttcggctc gcccaccggt ctacggctgc tccacggagc cgagttcagc
     4501 gccgacccgg accgccccgt acgctccgac gacctcgccg tcccggccgg cggcgaccgc
     4561 gccgaccgct gtctgctcct ctcgccgccg ctgcccggcc cgctcgacct ggcgggagcc
     4621 gccgtcgccc ggatcaacgt cacggccgac gcgccctgtg ccgactgggc cgtacgcctg
     4681 accgctctcg acccgtccgg ccacgcggac ccgctcgcct tcggcatcgt ccggcgcacc
     4741 gacccgccag gtgaggccgc cgacatcacc gtgccgctcg gcacgctggg ccgccggctg
     4801 cccgccggga cccggttgcg cgcggagatc gccggacacc actttcccgc ccacgcccgg
     4861 aacccgcaca ccggggagga cccggtcacc gccacccggc tcgccccgtc ccgccgcacc
     4921 gtgaaccccc ggggcagcgt cctccacctg cccgtcgtcg cccgacgccg ctacgtcgag
     4981 cccgcaccgg agatatgccg ttgaccagcg tcctgcccat cgaagcactc gtcgatcccg
     5041 tcagcgggat catccgtgac gtcgcgcccg tcgagcaccc cgccggtgcg ccgccccgct
     5101 acaccgcgat gaccgccgac gtcgccgacg cccgccgcct cggcgcctgg cccgccgacc
     5161 gcgtctcgct cggcaccacg ttcggcgacc cccggggcgc gtggatcgca gcggtggccg
     5221 aggccgtcga gcgctactgc ggcaaccgtc tcccgccgcc cggccacgcc caggcgccgc
     5281 gtcgggccac cgccgccgaa ctgaccgccg agggccaccg ggtctacggg ccgggcgctc
     5341 tgccggccta cgccccctgg cagttggtcc ggccgcgatt cccgtacgcc gaactcaccc
     5401 ccgacacacc ggcgctgtgg acccgggccg ccgagggcgg tcgcccctgc tgggcccccg
     5461 tcgcgctgac ccacctcaac tggcggcagg gcgaactgcg ttcgctgccc cgtacccacc
     5521 acctcaacta cgcgggcatc gccaccgggc agggcctcga cgacgccgtc gagcgcgggc
     5581 tcctcgaagt cgtggagcgg gacgccctgg agctgtggtg gcacctggac gggcccaccc
     5641 ggggcatcga cccggcgacc gtccccgggc tcaccgagga cctggccggc tgcgggctcg
     5701 acgtgcacat cgtggagatg ccctccgagt tcgccccctg cgtggcggcc ctcgtgcacg
     5761 accccggacg cggcatccac gcggccgggt tcgcctgccg gtacgacccg gcggaggcgg
     5821 cccgcaaggc cgtgctggag gccgtgcaca cctgggtgtt cacccagggc gcggtggacg
     5881 ccgacggctg ggtgtaccgg gcggtcgaag ccgggatgct cgcccgcggc ctctacctcg
     5941 accaccgcgc cgaccggcgc tatctcgacg actgcgggcc cgagttcgcc gccgtccggg
     6001 acctcggggc ccatgtccag gtctggctgg acgaccggat ggccccgctc gcccgccgct
     6061 tcaccgaacc cgccctcggc acggtcccgg tcaccgcgat cgatcccggc agccgtaccg
     6121 cgctcgacgc ggcgctcgcc gccggggggc accgggtgat caccgcggac ctcaccacgg
     6181 aggacgtcgc cgagacacca ctgcgcgtcg cccgcgtgct ggtctccgga ctgatcccca
     6241 acgcaccggc ggccttcggc tacttcggct gcccgcggtt cgcggacgcc gcgctcgcac
     6301 ggggctggcg cacccgaccg cccaccgcgc cgggggactt caccctggcc ccgcccccgc
     6361 acatgtgaag gagcgcgccg ccatgcccga caccccggcc cggaccgccg cccccgatcc
     6421 cgggacgcac cccgcgtccg gcctgctgcg ccgggccctc gcggacgccc gctcctcgcg
     6481 cgcgccgggc ctcgccccct acgtgcccga gcgcccgttc ccctggagcg ggcccgggct
     6541 gccgttgacc ggggtcgcgt tccggtccgg ggcgggtccg gggaccgggg gccgggccgc
     6601 gatcgacctg gaccgcgtcc tgcgcctctc cctggccgca cccgccggaa caccgggccg
     6661 actgcggccc gttccctcgg cgggagccct gcacccggtg cgcgcccacc tcctgatcgg
     6721 gccgcggtgc tcactgccgc ccggtcgcta cgcctacgac ccgcgcgccc accgcgccca
     6781 cccacgcggc ccggcccccg acggcgcacc cccgggcggg ctcgtcgtcc tcaccgtggc
     6841 cgcgtcccgc accgtcgtgc actacggcca tcgggcctgg ccgctcctcc tgctggacac
     6901 gggccacgcc gccgcggccc tggcactggc cgggcccccg gccgccgacg tacgggtctg
     6961 cctcgacgcg gacgccgacc ttctctccgc cgccgccgga ctgcccgccg cgccggactg
     7021 gccggacaca tggcccggca ccgagccgga actggccctc gcggcagtca ggttgacccc
     7081 tgccggcgtg accggcgacg acctcgggac actggccgtc tgggcctgcc cgccccgcgc
     7141 cggaaccccg tcgccgcaac ccggcgcgga gaccgccccg cccggcgaac tcgcggcgac
     7201 acggcatctg ttgcaccaca tcgcccgagc ccgcgaacgg cccggcggca cctggcaccc
     7261 ggctccccgc cccgcaccgg tgaccgacga ggcactggcg acccgccgga gcgccccgcc
     7321 cgacgacctg aaccacccgc ccagcgagga tctgctcgtc cggctcctga tcaccgcgcg
     7381 gacagcacgg ccggacggac ccgcctggac cgtggccgtc ggtgatgacg ccccggcgct
     7441 gtacgcgaag gcccccggca gccgcggcct cgccgtccgg gcctccgggg acgcgcgccc
     7501 caccctcgcc cgctgggccg ccggccagca gtggatcggc ggcgcgggcg cggtgctcct
     7561 cgcccacggc tgccccgggg acgccccgcc ggccgcggtc cgcagcggcc acctcgccgc
     7621 cgggtacgcg gccggagcgg tccagatcca cgccaccgcg ctgggcctgc gctcccggcc
     7681 gatcggctcc tggcagcggg cggacctggg cgctgcgctc ggcgaggcac ccggacgcga
     7741 ctgggtcatg cacggcctgg cggtgggggc gcccccaccg ccaggacccg ttgtccctgg
     7801 cttcgcccga cgcccaccga cgccgaacgt gccaccgacc ccgacggcac ctgacacagc
     7861 gaccacgaca cccgccactc cggcggctcc gcccggcgag gaagaacgcc catgatgctc
     7921 caccccgaac tcctgcgcgc cgcgaacacc gcgcgccgcc cgctcggtct cgccaccgcg
     7981 ctgctcgcgg cggtcacggc cacccacctc gcccaggccg tcctcctcgc cctcgtgctc
     8041 gcccggatcg cccgggggga gacggccacc ctccccccgc tgctcgccgc cgtcatcgcc
     8101 gtcgtcctgg tccgcgcagc cctcggccgc gcccagcgcc tgaccgccgt cacggcggga
     8161 gccgccgtac gggtgaggct tcgcgacacc ctgctggagc ggctcggcgc actcggcccc
     8221 accgcgatca ccggtgcgcg ggccggagcc gtgcgcgcca ccctggtgga cggcgtcgag
     8281 ggcgtcgacg cgtacatctc gcgctatctg ccccaagcgc tcatcacctg cgccgtcccg
     8341 ccgctgctgc tcgtcgccgt cgccctcgtc gagccgtacg cggccctcgc tctcggcccc
     8401 gccctcctgc tcgccctctt cgggccgcgc tggtgggacc ggctgctcgc gcggcgcggc
     8461 aaggagcact gggactccta cgaagccctc gccgccgact acctggaggc gctccaaggg
     8521 atgccgaccc tgcgggccac cggtgcggtg ggccgcgtac gggaacggct ggagcggcgg
     8581 tcggccgccc tgcaccggac caccgtcgcc aaactccgcg tctcgctcgt cgacaccggc
     8641 ctcaccgacc tggccgtcca gggcgggacg gccgccgccg tgctcgtggc gtgctcgtcg
     8701 gcggccaccg gccgtaccgc ggccaccggt acctatctcc tgctgctcct cgcctccgaa
     8761 tgcttccgcc ccgtccgcga cctctcccgc gagtggcacg cgggctacct cggggtgtcc
     8821 gcggccgacg gcatcgccgc cctgcgcacc gccgaagccg ccgtgcccga ccggggcacc
     8881 gtggccgccg cctggaagag cgcacccgaa gtccgtttcg aggacgtacg cttcacccat
     8941 cccgggagcg ggcggcccgc cctcgacggc gtcagcttca ccgccgcccc cgggcgcacc
     9001 acagccgtcg tcggtccttc cggggcgggg aagtcgaccc tgctgagcct gctgctgcgg
     9061 caacgggacc cggacagcgg ccgcctcacc gtcgccggga cggccaccgc cgcgtacacc
     9121 ctcgcctcac tgcgccgggg catcgccgtg gtctcgcagg acacctatct cttccacgcc
     9181 acgatcgcgg agaacctgcg gatcgcccgc ccggccgcca ccgacgaaca actgcgcgcc
     9241 gccgcccgca ccgccgggat cgaccaggag atcgcccggc tgccggacgg ctacgccacc
     9301 ctcgtcggcg aacgcggcgc cacgctctcc ggcggtcagc gccaacgact ggccctcgca
     9361 cgggcgttgc tggccgacgc ccccgtcctg gtcctggacg aggccaccag cgcggtcgac
     9421 gagcgcggcc aggcccgcat cgtgcgggaa ctcgcggcgg ccggccgggg ccgcacctgc
     9481 atcgtcgtcg cccaccggct cgacgccgta cgccacgccg accacatcgt cgtcctcgac
     9541 gcgggccgcg tcgcggcgac gggcgaccac accaccctgc tcgcgggcgg cggcgtgtac
     9601 gcctcgctcg tcgcggccgg gcgcaccgca caggaggagc gcgccgcatg accccgaccc
     9661 cgaccccggc cccggctcct gccccgaccg gccccacccg tccccccggg ccggaccccg
     9721 ccgccctcga cgacgccgcg accggggccc tgcgctcgct cctcccggtc ctgggcgcac
     9781 accgcgccac cgtcctgcgc acctgcctgg ccgccctcgt cgaccaggcg gccctggtcg
     9841 ccctcgtgac gctcgccgcg tacacggtgg gcacggccgt cacggagcac cgcccgccca
     9901 ccccggggac cgtcgccgtc ctgatcggac tcgtcctgct ccgggcgttc gccacctggc
     9961 gggagatgga cctctcgcac gacctcgcct accgggtcct cgccgaactg cgcgtccggg
    10021 tcttcgacgg gctggcccgc agcgcccccg cccggatcgc gggccggcgc agcggcgacc
    10081 tcgcgtccac cgcgctcggg gacgtcgagg cgctggagtt cttctacgcc cacgccatcg
    10141 cccaactcct cgcctccggc gtggtcttcg cggtgtcggc cgccgtgctg gcggccctcg
    10201 gcccctggct gctgctcgcc gtcgtccccg ccgcgctcct cctgatctgg tcgccgctct
    10261 tcgaagcgcg cggacgggcc gaacgcgggg cgcggacccg cggcgcgctc gccgaggtct
    10321 cgtccgagac cgtggagagc gtcgacgggc tgcgtgaact cctgatggcg ggagcgctga
    10381 accgcaggcg ggcccggctc cggtccgccg gacgcgggct cgcccgcgcc cagcgtgccg
    10441 aacagtcctg ggagaccggc gcgggagcca cccgcgatct gctggtcgtc gccgccgtca
    10501 tcggcgtcgt ggcggccgcc gcccacgccg cgtccgccgg acgtctggac ggggcgtggg
    10561 ccccggccgc catggcgctc gccctggggg ccctggctcc ggtcgccgaa tcggcggcgg
    10621 cactcggccg ggcgggcggc ctgcgcgccg ccgccgcccg ggtccgggcc gccgtgcacg
    10681 cccccgccgg agcccccgcc cctgccgccg cccgcaccgt accgccggga ccgctggggc
    10741 tgcggttgcg cggggtccgg ttcggctacg ggggagaggc cgtgctcgac ggcgtcgatc
    10801 tgaccgtccg gccgggcgag accgtggccc tggtcggagc ctccggggcg ggcaagtcga
    10861 cctgcgcaca cctcctggcg cggtactggg accccgaggg cggctccgtg gagctcgtgc
    10921 cccccgcccc ggcccgcccc gtggacctgc gggacctgac cgaggaggac ctgcgcgccg
    10981 tcgtgtccgt ggtggggcag gaggccccgc tcttccacgg cagcctcgcc gagaacctcc
    11041 ggctgggcgc tccggacgcc acggccgacg aactggacac ggtgacccgg atctgcggca
    11101 tcgcccccat cgccgacgcc ctgcccgacg ggctggacac cgccgtcggc gagcgcggcg
    11161 cgaccctgtc cggcggccag cgcgcccggg tggccctggc ccgggggctg ctgagcggcc
    11221 cgcgcgtact cgtcctggac gagacgacgg cacatctgga ccaccgcggt gacgaagaac
    11281 tgtcccgggc gctcgcggcc gactccgcca cccggacgac cctggtgatc gcccaccgcc
    11341 cggccacggt ccgcagggcc gaccggat
//
