LOCUS       NZ_CP117709            11338 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 chromosome, complete genome.
ACCESSION   NZ_CP117709
VERSION     NZ_CP117709.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8003288)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8003288)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6656169
            Orig. end                         :: 6667507
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117709.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11338
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="28"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11338
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11338
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6338](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6338)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    146..161
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.91"
                     /tool="antismash"
     misc_feature    complement(761..772)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     gene            820..2307
                     /gene="hemG"
                     /locus_tag="PSQ21_RS29535"
     CDS             820..2307
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956908.1"
                     /locus_tag="PSQ21_RS29535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_274034352.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6.1e-07, bitscore:
                     27.6, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 4.5e-14, bitscore: 51.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRSQQRAETPPGHVVVIGGGIAGLAAAHHLVANGLRVTLLEATD
                     RLGGKLMTGEVAGVQVDLGAESMLARRPEAVALAREVGLADRLQPPATATASLWTRDAL
                     RPMPKGHVMGVPGDPAVLGAVLSPEGLARIAEERDLTPTAVGDDVAVGAYVADRLGREV
                     VDRLVEPLLGGVYAGDAYRISMRAAVPRLFEAVREGGPLLEGVRRVQERAAARQRTGPV
                     FQGIEGGIGTLPTAVADAVRAGGGEILDRTPVLGLTRTESGWAVRTDARTIAADGIVLA
                     TPAWSAGTLLAAESPAASAELSGVEYASMALVTLAFRRADIERHEALRGRSGFLVPPVD
                     GHTIKASTFSSNKWQWVADSAPDLFVLRTSVGRYGEEDHLHREDTELVAASLRDLAAAT
                     GLTARPVDSEVTRWIGGLPQYPVGHLARVARIRDAVAALPALRVCGAVYDGVGIPACIA
                     SARRAADEIAGELKGEIAGEIIATSTLVRGTGSEAGQ"
     gene            2312..3040
                     /gene="hemQ"
                     /locus_tag="PSQ21_RS29540"
     CDS             2312..3040
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965515.1"
                     /locus_tag="PSQ21_RS29540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_026290345.1"
                     /transl_table=11
                     /translation="MSAPETVTSSKSPNAGKKAKDLNEVIRYTLWSVFKLRDVLPLDRA
                     GYADEVQELFDQLAAKDITVRGTYDVSGLRADADLMIWWHAETSDELQEAYNLFRRTKL
                     GRALDPVWSNMALHRPAEFNKSHVPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRM
                     LADHGKMARGYPDVRANTVASFSLGDYEWVLAFEADELYRIVDLMRHLRASEARLHVRE
                     EVPFYTGRRKSVADLVAGLA"
     gene            complement(3198..4760)
                     /locus_tag="PSQ21_RS29545"
     CDS             complement(3198..4760)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (101-476). E-value:
                     4.3e-18. Score: 57.7. Matches aSDomain:
                     nrpspksdomains_PSQ21_RS29545_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956907.1"
                     /locus_tag="PSQ21_RS29545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_274034353.1"
                     /sec_met_domain="PF00561 (E-value: 4.5e-24, bitscore: 84.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAALYTSIGSLVLSALAAAPADAREGRGSDEARGTAIAAARAT
                     AAGIDFVSCPEKEMLPDSLKCGTVKVPLDYAEPDGKQLELTVSRTGATGPADGRQGAFV
                     YNPGGPGASSITFPMAGELPEWKEIAEAYDLVGYAPRGVNGSSAPLTCQDPAAYTKGPT
                     DAPTHPTREHKERRVARAKAYAEGCAQHAGDTLRHYTSLNNARDLDVLRAALGEKRLTF
                     MGASYGTYFGALYATLFPSHVRRMVFDSVVDPDPEQIWYRSNMGQSLAFEARWEDFRRW
                     VAKHDDVYHLGDTPESVQRHYDEVRAGLAVEPAGGTVGPGQLHSAFLGAGYYDDYWAMR
                     ATALSEYVRGNPEPLVAQASPRAVAARDNENAQAVYTAVECNDAPWPEDFEVWDRDHTE
                     LARVAPFETWDNAFTNLPCAFWPAPRQRPMEVGTRWGELPPVLILAAERDAATPYKGAL
                     ELRKRLPGSSLVTERGAGTHGVGGAGNTCVDDHLRRYLLTGEVPGRGADCAARPEPNPV
                     SLD"
     aSDomain        complement(3333..4457)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PSQ21_RS29545_Abhydrolase_1.1"
                     /evalue="4.30E-18"
                     /label="PSQ21_RS29545_Abhydrolase_1.1"
                     /locus_tag="PSQ21_RS29545"
                     /protein_end="476"
                     /protein_start="101"
                     /score="57.7"
                     /tool="antismash"
                     /translation="AFVYNPGGPGASSITFPMAGELPEWKEIAEAYDLVGYAPRGVNGS
                     SAPLTCQDPAAYTKGPTDAPTHPTREHKERRVARAKAYAEGCAQHAGDTLRHYTSLNNA
                     RDLDVLRAALGEKRLTFMGASYGTYFGALYATLFPSHVRRMVFDSVVDPDPEQIWYRSN
                     MGQSLAFEARWEDFRRWVAKHDDVYHLGDTPESVQRHYDEVRAGLAVEPAGGTVGPGQL
                     HSAFLGAGYYDDYWAMRATALSEYVRGNPEPLVAQASPRAVAARDNENAQAVYTAVECN
                     DAPWPEDFEVWDRDHTELARVAPFETWDNAFTNLPCAFWPAPRQRPMEVGTRWGELPPV
                     LILAAERDAATPYKGALELRKRLPGSSLVTERGAG"
     misc_feature    complement(4997..5008)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 21.4"
                     /tool="antismash"
     gene            complement(5001..6338)
                     /locus_tag="PSQ21_RS29550"
     CDS             complement(5001..6338)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072529.1"
                     /locus_tag="PSQ21_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_274034354.1"
                     /sec_met_domain="DUF692 (E-value: 3.8e-91, bitscore: 303.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELGIGIGWRPEIADEVEALAGIDWVEAVAENLCAGHLPDSLVRL
                     RERGVRVVPHGVALGLGGADRPDPGRLASLAARAELLGSPLVTEHIAFVRAGGPLTASP
                     RLEAGHLLPVPRTWDALDVLCENVRIAQDSLPVPLALENIAALITWPDEELTEGRFLAE
                     LVERTGVRLLIDVANLHTNHVNLGQDPAKALDELPVEAIAYVHVAGGVERNGVWHDTHA
                     HPVTAPVLQVLAELRSRVDPPGVLLERDDAFPPAAELAGELDAIRATLWQAAPPADPRA
                     TAGDAARDGCGGGIGDGKGGRAPAVPVPAGTRDRTAVAQTALLSALVAGTPAPEGFDRR
                     RLRVQSRALAAKRADVVAKVAPELPEILGEGYRAAFLAYAGSRPMSGGYRRDALDFAEH
                     VLIAGGPADPVARRRLTYWRRDRSGARPPRRATRLVRAARAALVGK"
     gene            complement(6476..7219)
                     /locus_tag="PSQ21_RS29555"
     CDS             complement(6476..7219)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554825.1"
                     /locus_tag="PSQ21_RS29555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_274034355.1"
                     /transl_table=11
                     /translation="MTSHNAPAPAPESPFHDGPADRDQARQFVLPLVLHLEKTDPPART
                     DALRAAARAVLTILSDERSLGDGEWSGAMRDWQDARIRKVVRRARGAEWRKAAALDGIT
                     VTGEDGAEVRVFPPIPLDGWPKELAKLQVSGTELEDPEPPAAPDLSGPVLWLNPELDMS
                     AGKTMAQAGHAAQLAWWELSDTGREAWREAGFPLAVATPGAERWRELTVSGLPVVRDAG
                     FTEIAPGSCTVVADHPALRRRAGNG"
     gene            7291..7965
                     /locus_tag="PSQ21_RS29560"
     CDS             7291..7965
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="PSQ21_RS29560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AIM24 family protein"
                     /protein_id="WP_274034356.1"
                     /transl_table=11
                     /translation="MKSDLFSSDHLAQPATAPGMTLQNAKSIKYAVNGEMHARQGSMIA
                     FRGNLQFERKGQGIGGMLKRAVTGEGLALMAVRGQGEAWFAHEAANCFIVELDQGDSIT
                     INGRNVLCFDPTLSYEIKTVKGAGMVGGGLFNSVFTGYGKLGLMCEGTPIVIPVTAAQP
                     VYVDTDAVVGWSQQLTTSLNRSQSVGSMVRGGSGEAVQLMLQGEGFVIVRPSEARPEKT
                     SN"
     gene            7968..8936
                     /locus_tag="PSQ21_RS29565"
     CDS             7968..8936
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536943.1"
                     /locus_tag="PSQ21_RS29565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_274034357.1"
                     /transl_table=11
                     /translation="MELQGVGHRYGLRGAWVLRGVDLTLPERTLIRVEGGNGAGKSTLL
                     RLLAGIDAPAEGRITGRRARTAYVPERFPAALPLTATGYLVHLGRIHGLRSAEAKVRAG
                     EWLTRFGAADHARTPLAELSKGTSQKVAVAQALLAEPDLLVLDEAWTGLDTSARGELDR
                     AVAERVAAGATVVFVDHDPRRLAGAADLTLRTGEGGVQRATAPTPTGPVAGPRVLVEAE
                     GPPGAPLPAALPGGPVRERPAGAAPGLVRLTVPAPYSDALLAALLTARPPWHIRRVARA
                     EASGPAEAHGPAEAFGQASPRASVRTRSTEAPDTSEVSEAP"
     gene            8933..9601
                     /locus_tag="PSQ21_RS29570"
     CDS             8933..9601
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452202.1"
                     /locus_tag="PSQ21_RS29570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter"
                     /protein_id="WP_274034358.1"
                     /transl_table=11
                     /translation="MTALLRYQAALFARSQRWLAPLLLYAAVLAVGVRSGQPVLGSLGV
                     VAAAVLPVTAWAVHLCVAQEPPAARTVVSAAAGPRRAHLAALLTAAGCAAALAVVTTAV
                     VLLISDPVTDDGARTVSRQAAALAGLLAVLCCVLMGAAVGALSTRPVPLRRGWSVAAAV
                     LGSLLALVTAGSPARLAVTALVTGSRTGTVQPLALPLLGAVVLAAAVAFLVCRTAARRG
                     "
     gene            9610..9825
                     /locus_tag="PSQ21_RS29575"
     CDS             9610..9825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378551.1"
                     /locus_tag="PSQ21_RS29575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274034359.1"
                     /transl_table=11
                     /translation="MGVDTDTDADGTYCETPGPIAPPPPGDAAQGPPYAECVLCREPTE
                     YPESTKGATLCPVCAWQEAGRTACSG"
ORIGIN
        1 ctgggcgagc agcgactcca gatcggactg acggctgctc agctcgcctt ccagggccac
       61 cacatcgctg atcctctccg cccggtccat cagctcccgc acccgcgcca cgctcgcgcg
      121 ctgcgtggcg atccggctgt ccacgtcgac cacctggtcg gtgacgtcct tcgcgttcga
      181 ggtgcgcgac agcagcttcc cggagccggc cagctcccgc agcacctcct ggaaccggtc
      241 ctgcggcacc cgcaccacca ggtgcgaggt ctcgtgcgtg tcgtccagcc gctcggtcct
      301 ctccgtcgcc accagcccgc ccgcgccctc cgccgcggcg cgcgcggcgg cgacggcctt
      361 cgggacgctc ctcacctcga cggacagagc ggccgtgcgg atgacatgcg tcgccgccgc
      421 cttcgccccg gacggcttcc cgtccgcccg ctttccgtcc gcctgcttcc cgtccgacga
      481 cgcggccccg ccctcgtccg cggctcccgc cccggcctgt ccgtcggcgc gcccctcgga
      541 ggcgttcttg ccgtccgccg ccttcgcgcc gctgtccgac gcgtcgcccg tcgccccgca
      601 gccgccgacg gcgagcagga ggccgagcac cccggccacg agcgccgccc gcccgcgcgc
      661 gagcgatcga tcggttctgc tgttccattc cataactggt ccccccagga cggtggttga
      721 tggtgccggt tcgacgcgtc cgccccgggc ccggttgccg gacagcggtt tcgaagtggt
      781 cacggtcagg acgcggcacg ggtttgagag agtggaccca tgcagcgttc tcaacagcgt
      841 gcggaaacgc ccccgggcca cgtcgtcgtc atcggcggtg gcatcgccgg tctggcggcc
      901 gcccatcacc tggtcgccaa cggactgcgg gtcaccctcc tggaggcgac ggaccggctc
      961 ggcgggaagc tcatgaccgg cgaggtcgcg ggcgtccagg tcgacctggg ggccgagtcg
     1021 atgctcgccc ggcgccccga agcggtcgcc ctggcccgcg aggtgggcct cgccgaccgg
     1081 ctccagccac ccgccaccgc caccgcctcg ctgtggacgc gcgacgcgct gcgccccatg
     1141 cccaaggggc acgtgatggg cgtccccggt gatccggcgg tgctcggtgc ggtgctgtcc
     1201 cccgaggggc tggcccggat cgccgaggag cgcgacctca ccccgaccgc cgtcggcgac
     1261 gacgtggcgg tcggcgcgta cgtcgccgac cggctgggcc gcgaggtcgt ggaccggctg
     1321 gtcgagcccc tcctcggcgg cgtctacgcc ggtgacgcct accggatctc gatgcgcgcc
     1381 gccgtccccc ggctcttcga ggcggtgcgg gagggcgggc cgctgctgga gggcgtacgc
     1441 cgcgtccagg agcgggccgc cgcccggcag cggaccgggc ccgtcttcca gggcatcgag
     1501 ggcggcatcg gcaccctccc gaccgccgtc gccgacgccg tccgggccgg cgggggcgag
     1561 atcctcgacc ggacccccgt cctcggcctg acccgtacgg aatcgggctg ggccgtccgc
     1621 accgacgccc ggacgatcgc cgccgacggc atcgtcctgg ccacccccgc ctggtccgcc
     1681 ggcacactgc tggccgccga gtcacccgcc gcgtccgccg agctgtccgg cgtcgagtac
     1741 gcctcgatgg ccctggtcac cctggccttc cggcgggccg acatcgaacg ccacgaggcc
     1801 ctgcgcggcc gttccggctt cctcgtaccg ccggtcgacg gccacacgat caaggcgtcc
     1861 acgttctcca gcaacaagtg gcagtgggtc gcggacagcg cccccgacct gttcgtgctc
     1921 cgtacctccg tcggccggta cggcgaggag gaccatctgc accgcgagga cacggaactc
     1981 gtcgccgcct ccctgcgcga cctcgccgcg gccaccgggc tcaccgcccg gcccgtggac
     2041 tccgaggtca cccgctggat cggcggcctg ccgcagtacc cggtcggcca cctcgcccgg
     2101 gtcgcccgga tccgcgacgc ggtcgcggcg ctccccgccc tgcgggtctg cggcgcggtc
     2161 tacgacgggg tcggcatccc cgcctgcatc gccagcgcgc gccgggcggc cgacgagatc
     2221 gcgggggagc tgaaggggga aatcgcggga gagatcatcg ccacgtcgac cctggttcgg
     2281 ggcacgggga gcgaggcggg acaatagccg tatgagtgct cctgagactg tgacatcaag
     2341 caagagtccg aacgccggca agaaggccaa ggacctcaac gaggtcatcc gctacaccct
     2401 gtggtcggtc ttcaaactgc gcgacgtgct cccgctggac cgcgcgggat acgccgacga
     2461 ggtccaggag ctgttcgacc agctcgcggc caaggacatc accgtccgcg gcacctacga
     2521 cgtgtccggg ctgcgggccg acgccgacct catgatctgg tggcacgccg agacctcgga
     2581 cgagctccag gaggcgtaca acctcttcag gcgcaccaag ctcggccgcg ccctcgaccc
     2641 ggtctggtcg aacatggcgc tgcaccgtcc ggccgagttc aacaagtccc acgtcccggc
     2701 gttcctcgcc gacgagacgc cgcgcgacta catcagcgtc taccccttcg tccggtccta
     2761 cgactggtac ctgctgcccg acgaggaccg ccgccgcatg ctcgcggacc acggcaagat
     2821 ggcccggggc tacccggacg tccgcgccaa caccgtcgcc tcgttctcgc tgggcgacta
     2881 cgagtgggtc ctggccttcg aggcggacga gctgtaccgc atcgtcgacc tgatgcgtca
     2941 cctgcgcgcc tccgaggcac gtctccacgt gcgcgaggag gtcccgttct acacgggccg
     3001 caggaagagc gtcgcagacc tggtggccgg gctcgcataa ccagcgagtc ccgcaccacc
     3061 ccaacccgga agatcagaac gacgggcacc gggcaccgat cgtgccgccc gccgttccag
     3121 cgacaccggg ttcggcttcg ggggccgtcg caccgtgatg gtgcggcggc ccccgctccg
     3181 tacctcccgc cggagggtca gtccagcgac accgggttcg gctccggacg cgcggcgcag
     3241 tccgcacccc gccccggcac ctcaccggtc agcagatacc ggcgcagatg gtcgtcgacg
     3301 caggtgttcc cggccccgcc gacgccgtgc gtcccggcgc cccgctcggt caccagcgac
     3361 gacccgggca gccgcttccg cagctccagc gcccccttgt acggggtcgc cgcgtcccgc
     3421 tccgccgcca ggatcagcac cggcggcaac tcgccccacc gcgtcccgac ctccatcggc
     3481 cgctgccggg gcgcgggcca gaaggcgcac ggcaggttcg tgaaggcgtt gtcccaggtc
     3541 tcgaagggcg cgacgcgcgc cagttccgtg tggtcccggt cccacacctc gaagtcctcg
     3601 ggccagggcg cgtcgttgca ctcgacggcc gtgtacaccg cctgcgcgtt ctcgttgtcc
     3661 ctggccgcca ccgcacgggg ggaggcctgc gcgaccagcg gctccgggtt gccccggacg
     3721 tactcggaga gcgccgtcgc ccgcatcgcc cagtagtcgt cgtagtaacc ggcccccagg
     3781 aacgccgagt gcagctgccc cggccccacc gtgccgcccg cgggctccac cgccagcccg
     3841 gcgcgcacct cgtcgtagtg gcgctgcacc gactcgggtg tgtcccccag gtgatagacg
     3901 tcgtcgtgct tggccaccca gcggcggaag tcctcccacc gcgcctcgaa ggccagcgac
     3961 tgacccatgt tcgagcggta ccagatctgc tccgggtccg ggtcgaccac cgagtcgaag
     4021 accatgcgcc gtacgtggga ggggaacagc gtcgcgtaca gcgcgccgaa gtacgtcccg
     4081 taggacgccc ccatgaaggt cagccgcttc tcgccgagcg cggcccgcag gacgtccagg
     4141 tcacgggcgt tgttcagcga cgtgtagtgc cgcagcgtgt cgcccgcgtg ctgagcgcag
     4201 ccctccgcgt acgccttcgc gcgggcgacc cgccgctcct tgtgctcccg cgtcgggtgg
     4261 gtcggcgcgt cggtcgggcc cttcgtgtac gcggcggggt cctggcaggt cagcggggcg
     4321 gaggagccgt tcaccccgcg cggggcgtag ccgaccaggt cgtacgcctc ggcgatctcc
     4381 ttccactccg gcagctcgcc ggccatcggg aaggtgatgc tggacgctcc ggggccgccc
     4441 gggttgtaga cgaacgcgcc ctgccggccg tcggccgggc cggtggcccc ggtgcgactc
     4501 acggtcagtt cgagctgttt cccgtccggt tcggcgtagt cgaggggcac tttcaccgtg
     4561 ccgcacttca gggagtccgg gagcatctcc ttctccgggc aggagacgaa atcgatcccg
     4621 gcggccgtgg cccgggcggc ggcgatcgcc gtgccccggg cctcgtcgga gccccggccc
     4681 tcccgggcgt ccgcgggggc ggcggccagg gcggacagga ccagggagcc gatcgatgtg
     4741 tacagcgcag cagttctcac gcgcggtgcc tctctgcgga tgcggagagg gatggtcggg
     4801 cacgcgggac gtgatgtcca gcaccggccg ggcatgtccg gggccatgac cccgatgggc
     4861 ggtcggatgc cgggacgccg ggccccgttc aggagccgcc gcccccacgg gagcctcccg
     4921 ggctggagcc cccgctgctc gatccgccgc cgcaccgggt gggcccgggg tcgccggcgg
     4981 agcgggcacg ttcagggcgt tcacttcccc acgagggcgg cacgggccgc ccggaccagc
     5041 cgggtggcac ggcgaggggg ccgggctccc gaccggtccc gccgccagta cgtcagccgg
     5101 cgccgcgcca ccggatcggc gggaccgccc gcgatgagca catgctccgc gaagtccagg
     5161 gcgtcgcgcc ggtacccgcc ggacatcggg cggctgcccg cgtacgcgag gaacgcggcg
     5221 cgatagccct cgccgaggat ctccggcagc tccggcgcga ccttggccac gacgtcggcg
     5281 cgcttggcgg ccagcgcccg gctctgcacc cgcagccgcc ggcggtcgaa cccctcgggc
     5341 gccggcgttc ccgccaccag cgcggagagc agcgcggtct gcgcgacggc ggtacggtcg
     5401 cgggttccgg ccggcacggg gaccgcgggc gcacggcccc ccttgccgtc cccgatgcca
     5461 ccgccgcacc cgtcgcgtgc cgcgtccccg gccgtggcac gcgggtcggc cgggggagcc
     5521 gcctgccaca gcgtcgcccg gatcgcgtcc agttcgcccg ccagctccgc ggccggcggg
     5581 aaggcgtcgt cgcgctccag cagcacgccc ggcgggtcga cccgggagcg gagttcggcc
     5641 agcacctgaa ggaccggagc ggtcaccggg tgggcgtgcg tgtcgtgcca gacgccgttc
     5701 ctctcgaccc cgcccgccac atggacgtac gcgatggcct ccaccggcag ctcgtccagc
     5761 gccttcgccg ggtcctggcc caggttgacg tggttggtgt gcaggttggc cacgtcgatc
     5821 agcagccgca ccccggtccg ctcgaccagc tccgccagga accgcccctc ggtcagctcc
     5881 tcgtccggcc aggtgatcag cgccgcgatg ttctccaggg cgagcggcac cggcagcgag
     5941 tcctgcgcga tccgcacgtt ctcgcacagc acgtccagcg cgtcccaggt gcgcggcacc
     6001 ggcagcagat gccccgcctc cagcctcggc gacgcggtca gcggcccccc ggcccgtacg
     6061 aacgcgatgt gctcggtcac cagcggcgac cccagcagct cggcgcgcgc cgcgagggag
     6121 gcgaggcgcc cggggtccgg gcggtcggcg ccgcccagcc cgagcgccac cccgtgcggc
     6181 acgacccgca cgccacgctc ccggagccgt accagggagt ccgggagatg gccggcgcag
     6241 aggttctccg cgacggcctc gacccagtcg atccccgcca gcgcctccac ctcgtccgcg
     6301 atctccggcc gccagccgat gccgatgccc agttccatgg tgtttccccc gtccccctgc
     6361 tcacctcgtt ctgttcaggg gtcatgaccc cgtcacgcgg cgacgaaccc gaccggaggg
     6421 acgttcagag ctatatctga ggttcccggg ccgccggccc gtcagggcat cggcctcagc
     6481 cgttcccggc gcggcgacgc agcgccgggt ggtcggcgac caccgtgcag gaccccgggg
     6541 cgatctcggt gaaccccgcg tcgcgcacca ccggcagccc gctcaccgtc agctcccgcc
     6601 agcgctccgc gcccggggtg gcgacggcga gcgggaaccc ggcctcgcgc cacgcctcgc
     6661 gcccggtgtc ggacagctcc caccaggcga gctgcgccgc gtgtcccgcc tgcgccatcg
     6721 tcttgcccgc cgacatgtcc aactccgggt tgagccacag gaccgggccg gagagatcgg
     6781 gcgcggcggg cggctcggga tcctccagtt cggtgcccga cacctggagc ttggccagct
     6841 ccttgggcca gccgtccagc gggatcggcg ggaacacccg tacctccgcc ccgtcctcgc
     6901 ccgtcaccgt gatgccgtcc agcgccgcgg ccttgcgcca ctccgcgccg cgcgcccggc
     6961 gcacgacctt gcggatccgg gcgtcctgcc agtcccgcat cgcccccgac cactcgccgt
     7021 cgcccaggga ccgctcgtcg gagaggatcg tcagcacggc acgggcggcg gcgcgcagcg
     7081 cgtcggtgcg ggcgggcggg tccgtcttct ccaggtggag cacgagcggc agcacgaact
     7141 gccgcgcctg gtcgcggtcg gccgggccgt cgtggaacgg gctctcgggg gcgggggcgg
     7201 gggcgttgtg gctggtcacc ttcccagtct gccaggccgg aaaggtcgcc tgcttggcgg
     7261 aacgaccagg tccgggtgag gatgctccgc atgaagagcg atctcttttc cagcgaccac
     7321 ctggcccagc cggccaccgc ccccggcatg accctgcaga acgccaaatc gatcaagtac
     7381 gccgtcaacg gggagatgca cgcccggcag ggatcgatga tcgccttccg cggcaatctc
     7441 cagttcgagc gcaagggcca gggcatcggc ggcatgctca agcgcgcggt caccggcgag
     7501 ggcctggcgc tcatggcggt ccggggccag ggcgaggcgt ggttcgcgca cgaggcggcg
     7561 aactgcttca tcgtcgagct ggaccagggc gactccatca ccatcaacgg ccgcaacgtc
     7621 ctctgcttcg accccacgct ctcctacgag atcaagaccg tgaagggcgc cggaatggtc
     7681 ggcggcggcc tcttcaacag cgtcttcacg ggctacggca agctcggcct gatgtgcgag
     7741 ggcaccccga tcgtgatccc cgtgaccgcc gcccagccgg tgtacgtgga cacggacgcg
     7801 gtcgtcggct ggagccagca gctcacgacc agcctgaacc gctcgcagag cgtcggctcc
     7861 atggtgcgcg gcggatccgg cgaggccgtc cagctgatgc tccagggcga gggtttcgtc
     7921 atcgtgcggc cgagcgaggc caggccggag aagacctcca actgaccgtg gaactccagg
     7981 gcgtgggcca ccgttacggc ctccgcggcg cctgggtgct gcgcggggtc gacctcacgc
     8041 tgcccgagcg gacgctgatc cgggtcgaag ggggcaacgg cgcgggcaag tccaccctgc
     8101 tgcggctgct cgccgggatc gacgctcccg ccgaggggcg gatcaccggc cgccgggccc
     8161 gcaccgcgta cgtccccgag cgctttccgg cggcgctgcc cctgaccgcc accggctacc
     8221 tcgtccacct cggccggatc cacgggttgc ggagcgccga ggcgaaagtg cgggcggggg
     8281 agtggctgac ccggttcgga gcggcggacc acgcccgtac cccgctcgcc gaactctcca
     8341 agggcaccag ccagaaggtc gccgtcgccc aggcgctgct cgccgaaccg gatctgctgg
     8401 tcctggacga ggcctggacc ggactcgaca cctccgcccg cggcgaactg gaccgtgccg
     8461 tggcggagcg cgtcgcggcg ggcgccaccg tcgtcttcgt cgaccacgac ccgcgacgcc
     8521 tggccggggc ggcggacctc accctgcgga ccggggaagg cggggtccag cgggcgacgg
     8581 ccccgacgcc gacgggcccc gtcgccggcc cccgtgtcct ggtcgaggcc gagggcccgc
     8641 ccggcgcacc gctgcccgcc gcgctgccgg gaggcccggt ccgggagcgg ccggccggcg
     8701 cggcccccgg cctcgtacgc ctcaccgttc ccgcgcccta ctccgacgcg ctcctggcgg
     8761 ccctgctcac ggcccgtccg ccctggcaca tccggcgggt cgcccgggcc gaggcctccg
     8821 ggccggctga ggcacacggc ccggccgagg cgttcgggca ggcctccccc cgggcgtccg
     8881 tacggaccag gagcaccgag gcgcccgata cctccgaggt gtccgaagcg ccgtgaccgc
     8941 cctcctccgc taccaggccg ccctgttcgc ccgctcccag cggtggctgg cgcccctcct
     9001 gctgtacgcg gccgtcctcg ccgtcggcgt gcggagcggg cagcccgtgc tgggctcgct
     9061 cggcgtcgtg gccgccgccg tgctgcccgt caccgcgtgg gccgtacacc tctgcgtggc
     9121 ccaggagccg cccgccgccc ggacggtggt ctcggccgcc gcggggcccc ggcgggccca
     9181 cctggccgcg ctgctcaccg ccgcgggctg tgcggcggcg ctcgccgtgg tgaccaccgc
     9241 cgtcgtcctg ctcatcagcg acccggtcac cgacgacggg gcgcgcacgg tctcccggca
     9301 ggccgccgcg ctcgccggac tgctcgccgt cctgtgctgc gtgctgatgg gcgcggccgt
     9361 gggagcgctg agcacccgtc cggtgccgct ccgccggggc tggtccgtcg cggcggccgt
     9421 gctcgggtcg ctcctcgccc tcgtgaccgc cgggtccccg gcgcgcctgg ccgtcaccgc
     9481 cctcgtcacg gggtcgcgga ccgggacggt ccagccgctc gccctgcctc tgctgggggc
     9541 ggtggtcctc gccgcggcgg tggcgttcct cgtctgccgg accgccgccc ggcgcgggtg
     9601 agtaggctcg tgggcgtgga caccgacacg gacgcggacg gcacgtactg cgagaccccg
     9661 gggccgatcg cgccgccccc gccgggcgat gccgcccaag gccctccgta cgccgagtgc
     9721 gtgctgtgcc gcgagccgac cgagtacccg gagtcgacga agggcgccac gctctgcccg
     9781 gtctgcgcct ggcaggaggc gggtcgcacg gcctgctccg gctaggaggc cgaaccgggg
     9841 gagggccgaa ccgggggagg gccggtcgga ggggcggccg agccgcgagg aacctgtgcg
     9901 tgacgccgtc gctcagcgca cccggaagac cggtccgcgc ggggtgaacg gcagccccgc
     9961 gccctccggg atcaggtacg cgtgctcgcg gcggacccgg agcacgtcgc accagccgtc
    10021 ggtgatcacc aggaccgggg ccgtcggcgg gaagtcgtcg gcccgttgca gcaggtcgac
    10081 gccgggttgc aggaccgtgc cgccgcgccc cctgacccgt acccgcccgg cgatctccgt
    10141 cggcgccagg taaccggcgt cgtaggcggc ggcgtcgcag aacaccacgc gggcggccgg
    10201 cacgtcgcgg gcctcggcgt aggaggcgat cgcgcccagc gccttggcga ggagccggcc
    10261 ggacatcgag cccgaggtgt ccaggacgac gccgaaggtg cagcgggcga cctcctcggg
    10321 cgggaagcag cggcccgcgc gcgggatgtc gggggtcgag gcctggcgcc gggcgggccg
    10381 ggagtagctg cgtaccggct cgggccgggg cacgaactcg tcgaaccagc gggccagccg
    10441 ggcatcccac gggacgggtg ggtgggcgag ggcgcggatc tcctggacca gtccggccgg
    10501 cagcaggccg cgctgtcggt cggtgtgcag ctggtggccc tggacgaggg cgcgccggta
    10561 gaacgcgtcg aggtcgacgg ggtcggcggt ccggccgggc aggggttcgc ccaggatgtc
    10621 cccggtgccc tttccgcgca gggtcgcgag gcgccggccg cgccgcagcc cggtggcgat
    10681 ccggtcgtac acctcctcgg tcgacaggcc cttcaactcg gggtcgtaca gcagcccttc
    10741 gggcatcgcg ccgacgccca tctccaccag ccagccgttg atgacgtagt cggcggcgac
    10801 gttgaagaga tagggatcgc gggcgccgcg gcgcccgccg tggcgcaggg cggcgtgcag
    10861 catctcgtgg gcgaggacga accgccactc ctcgtcggtg aaccgcttga gcgggttgat
    10921 gtagatctca ccggcggcgg cgtccacggc ggccacggag atggcgtgcg cgcgggcgag
    10981 ttcggcgtcg gcgacgacgg tcagtccggc cgcgaggccg ccgagcaacg ggtaggagga
    11041 gacgaaccag ttgagggcgc ggtcccaggg ggcctgggcg acgcgctcac cggtgagccg
    11101 gtcccggcgg ccgcccgcga cgtccatcgc ggcggagacc gtacgggtca gggcgtacgc
    11161 gaaggcgagt tgccggtcgg gcagggtggt ttcgtggtgc ggccacggga ccaggagctg
    11221 gtcgggttcg ccgtcagcgg tgccgcaccg ctcgtaggcg gccgggacgc cggtcttgcg
    11281 ccagcgggcg gcgagctgtt cctcgtcgcc gtcggggtag ctctcgggga ggtggtcg
//
