LOCUS       NZ_CP117709            10420 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 chromosome, complete genome.
ACCESSION   NZ_CP117709
VERSION     NZ_CP117709.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8003288)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8003288)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5402258
            Orig. end                         :: 5412678
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117709.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10420
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="21"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10420
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10420
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5420](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5420)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    849..865
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.55"
                     /tool="antismash"
     misc_feature    complement(856..876)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.0"
                     /tool="antismash"
     misc_feature    881..890
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.64"
                     /tool="antismash"
     gene            1106..2629
                     /locus_tag="PSQ21_RS24210"
     CDS             1106..2629
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379206.1"
                     /locus_tag="PSQ21_RS24210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_274032918.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1e-28, bitscore:
                     99.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLQLSVVVPCFDEAEVIESFHAALLGVLDSLGDSFEICYVDDG
                     SRDRTRPLLSAIAARDPRIHYTAFSRNFGKEAAMLAGLRMSRGAAVVIMDADLQHPPEL
                     IPRMLELHRHGYDQVIPRRDRAGEGMLRSTLSHTYYALVRRCMDVELIDGSGDFRLLSR
                     RAVESVLSLPESNRFSKGIFSWIGFDTVTFRYRNSERVAGRSKWGSKRLLNYGIDGLLS
                     FNNRPLRLAIYTGFWVFVSALVYALWTVVGVVLHGADTPGYATLLTAVVALSGIQLVTL
                     GVIGEYVGRIYHEAKHRPPYVVRETDATRRALPAGPPSRPRLTGGPGERATPPAPAAMA
                     EAPAPAPATGAPGRSRTARQFGSFVLIGCVNTAVYLGIYASLNRWIPYLTAHVVGYAVS
                     IVCSFLLNSYVTCRTRPTWHGFVRYPLSSLVNLVASGALLYGAVSGLGMDKNLAALAAG
                     VLVTPVSFLLARWAITSGRSRAATAVPQAGPQAGRPVPGPLPTRSSQEG"
     gene            2638..4152
                     /locus_tag="PSQ21_RS24215"
     CDS             2638..4152
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072027.1"
                     /locus_tag="PSQ21_RS24215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6056 family protein"
                     /protein_id="WP_274032919.1"
                     /transl_table=11
                     /translation="MSDDVPVTAAPEKPRRGEETSDPAAGRPSDRPWTALWVSALALPP
                     LALLAAASWFGRWVRPGADDWCFLPAVRDDGVMGLVGKFYFDDNGRVANALLVGAYAKF
                     QVAGHQWYPLISGALVLAVLWAVAVLALRRARLRTPRGLPLLLAALSTALFLFVTPNTY
                     KTFYWPAASVSHTLPPVLACAALIPFLLARSRRGRVLALAVAALMGAFLATLSEETAIV
                     VVVVLLTALLLSGRVVPAPDRGFVRRWCAAGIAGTAAGAVVLITSPGSTRRRDRFGAET
                     TSLLAPDSLTASLRAFAEIAVTVATTWQYVGAVAAGVLLGLLCRRADGTPPRPPAHVPL
                     LIAAGVLALLVSGYLCTVIAYPVFGDRVSDPGANRLWNDYLLLYVILLVGAGALLGMAL
                     RRHPRRTAPAKAVCAALCVLVCVGPAVALTNLETAMRARAEKWDAQDRRLREGAEAGKR
                     VLPYERLVISNMLEPFSQGGRSYWPGGCVADLYGLDRVTDGTRDAP"
     gene            complement(4160..4984)
                     /locus_tag="PSQ21_RS24220"
     CDS             complement(4160..4984)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379204.1"
                     /locus_tag="PSQ21_RS24220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_274032920.1"
                     /transl_table=11
                     /translation="MTVRKNQANLTAPEKKAFVDAVLEVKRTGVYDTFVQTHLTRFSID
                     MNSGVYVGHFGPSFLPWHRKFLIDFENELQKVDASVSIPYWDWTADNTVGSSLWAPDFL
                     GGTGRVLDDQVMDGPFAYSGGNWTISVSVDSRPFLARRLAYRVPTLPPRSEVDAALAMP
                     TYDSPPFRDGSAGFRSTLEGTAGYMSMHNRVHTWVWGHMETSVSPNDPVFWLHHSFVDK
                     LWADWHALHPTSAEYLPAGGTVDVIDLNETMPPWPNTTPQDMLDHTQFYTYA"
     gene            complement(5001..5420)
                     /locus_tag="PSQ21_RS24225"
     CDS             complement(5001..5420)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966560.1"
                     /locus_tag="PSQ21_RS24225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase cofactor"
                     /protein_id="WP_274032921.1"
                     /sec_met_domain="melC (E-value: 6.3e-41, bitscore: 138.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKPTRRQALGAVIGVAATGALVGMAAASTETVAAEATSNDRTPG
                     GTGAPGSFDEVFKGRRIQGTPTEAHAHAGHGGHAGHGAYRVLIDGRELPVMQHGKSGWS
                     STINHYERFATPLEAARTAVISLKGAVIVPFDPTA"
     misc_feature    5420..5438
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(5519..5534)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.21"
                     /tool="antismash"
     gene            complement(5857..6837)
                     /locus_tag="PSQ21_RS24230"
     CDS             complement(5857..6837)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379202.1"
                     /locus_tag="PSQ21_RS24230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_274032922.1"
                     /transl_table=11
                     /translation="MRRLLRTLAVSAFACLLLPLGTGQQATAATTSADPIGMTDGFYTD
                     PHSTPAAWVAANPGDGRAAAIRDNISSRPMARWFGSWSGDIGAAVGSYVGAADAADKLP
                     VLIAYNIPGRDACGGHSGGGAGTPSAYRTWISAFASAIGARPALVVIEPDSLGDFSCLN
                     QAQIDERNGMLKDALAQFAAHAPNTWTYLDAGNPAWIGAATMAQHLDGAGARQAHGFSL
                     NVSNYYGTGENSAYGNAVNGSLAASYGYTKPYVIDTSRNGNGSNGAWCNPGGRRTGAVS
                     QTGGGAEMLLWLKTPGESDGDCGVGAGSVAGQFLPEVAYKMIYGY"
     misc_feature    complement(6853..6867)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    6854..6868
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     gene            complement(7080..8099)
                     /locus_tag="PSQ21_RS24235"
     CDS             complement(7080..8099)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379201.1"
                     /locus_tag="PSQ21_RS24235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274032924.1"
                     /transl_table=11
                     /translation="MENMIPRGSWLGDDTFRELVREVIPLRFGSWSLSEFEHATSELGW
                     ELREPKEIVGQVWRRFAPRKGPRSGYGTVISDASAPDQVRKLNVRVVDLPADDTASAAG
                     LVRAAWWVMEDELGPPAMWGGDSGPWMLWRLPGACLLVHSHDEGEVSLELLPPDADADA
                     AGRGYSRGRWRAADPAGPPSAPVASQATGTTWDEVEKHLSETLRSLDYDTPFFPGRFIL
                     HLGSADDPQRFVQGWSQDLGLVIEATGYLHQPDAADPDRLARSGWKSSPSVWQRRFPDA
                     MDDPAHAATAARMLVGELRHLGVGLADLSYDGTTTGRGRGFHLDLPDLGIPRVHRPAV"
     gene            8206..8655
                     /locus_tag="PSQ21_RS24240"
     CDS             8206..8655
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956219.1"
                     /locus_tag="PSQ21_RS24240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PaaI family thioesterase"
                     /protein_id="WP_274032925.1"
                     /transl_table=11
                     /translation="MEAHASQLAFGRQVLDAQPFSVLLGARLTAFGDGAAVLELDVRDE
                     LRQQNGFVHGGVLSYAADNALTFAAGAAAGPSVLTAGFTIDYLRPARGEVLRARAQVVR
                     PGRTRVVCRCDLLMVDTAGMETLCAVAQGTIAVASGRPPEPTATG"
     misc_feature    8210..8226
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            complement(9337..9567)
                     /locus_tag="PSQ21_RS24250"
     CDS             complement(9337..9567)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956220.1"
                     /locus_tag="PSQ21_RS24250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_274032928.1"
                     /transl_table=11
                     /translation="MIDGKKLYALDISSARFTKACGGNTHPDGESCVTLARIGDDAWAL
                     GDSKRPDATPLRFTTAELDAAGITPAAFGLA"
     misc_feature    complement(10017..10031)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.36"
                     /tool="antismash"
     misc_feature    complement(10034..10049)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.62"
                     /tool="antismash"
ORIGIN
        1 ttggcccgcc cgtccagctc cggcagcggc tccggcgcac cgcccgcccc cgcgccccgg
       61 ccccagccgg tggccgccgg ggtggtgcgg gtggtcgtac gccgtctgcg ccgggcgtac
      121 gcgtaggcgc cgaccgcgcc cacgcccgcc acgacgacca ccggcaggat gatgtcgcgg
      181 gcgccggtgg agccggagcc gtccgtaccg gggtcggcgg gccccggggt gatggcgggg
      241 gcggtcaccg gacgtccggc cagtacggag ccgtagccgt cggcagcgcc gatcgcggcc
      301 ccggcccagt cgttctcccg cagcgcgggt tcgatcgcgg tgcccgccac ctcccgcagc
      361 tgctcgtcgg tcagcgggga cccggcgtcg acggagtagg cgtactggcg gtcgtgggtg
      421 gcgacggaga gcagcacgtc gtcctggccc aggccgttgc ggtcggcggt ctcgtcgctc
      481 cacgtctgtc cggaccggcc ggagaaatca cgtacgtaca ccacgaagag ctggaggcgc
      541 tcgtcgtcgt acaaccggtc gagcgcgtcc tccacctgcc ccgcccggtc gcccagagcc
      601 cccacccggt cggtgacctg cccctcccgg gacagctcga cggggtcgtc ggcacgggcg
      661 gtcgcggcgg cggggagcac cagccagcac acggcggcca gcacggcgag gaggccggcg
      721 agagcgcggc cgacgcgcag gccgctgcga ggaccggcgg gagggccgct gcgagggccg
      781 gccggagggc cggtggaccg gcagggaagc cgggcaccgc cgggggcggt gctccggagc
      841 cgtgtccgtg gatgaaatat cacctttgcg aggctatgtg tgctttttga ccctcgcgac
      901 ccggcgtact gccgacccgc gtcggctgtt cgcatgaaag ggcgcgggaa agagacaccc
      961 ccgcgcgtgt acggagggac gggggcagcc gtccgtcgtc agatgggcgg acgtggcgcg
     1021 ttccggggcc cggtgccgga ggccgacggt gcccgcgccg gtgaggtccg gcacccacga
     1081 ggggcccgaa gtccggaggt ggcgtgtgac tggccttcag ctgtcggtcg tcgtgccgtg
     1141 cttcgacgag gccgaggtca tcgagtcctt ccacgccgcc ctgctcggcg tcctggactc
     1201 cctcggggac agcttcgaga tctgctacgt cgacgacggc agccgggacc gcacccgccc
     1261 gctgctcagc gccatcgccg cccgtgaccc gcgcatccac tacaccgcct tcagccgcaa
     1321 cttcggcaag gaggccgcca tgctcgccgg cctccgcatg tcgcgcgggg cggccgtggt
     1381 gatcatggac gccgacctcc agcacccgcc cgagctgatc ccccgcatgc tggaactgca
     1441 ccggcacggc tacgaccagg tcatcccgcg ccgcgaccgc gcgggcgagg gcatgctccg
     1501 cagcaccctc agccacacct actacgcgct cgtccgccgc tgcatggacg tggagctcat
     1561 cgacggctcg ggcgacttcc ggctgctgtc gaggcgagcg gtggagagcg tgctgtccct
     1621 tcccgagagc aaccgcttct ccaaggggat cttctcctgg atcggcttcg acacggtcac
     1681 cttccgctac cgcaacagcg agcgggtggc gggccggtcg aaatggggca gcaagcggct
     1741 gctgaactac ggcatcgacg gactgctctc cttcaacaac cggccgctcc gcctcgcgat
     1801 ctacaccggc ttctgggtct tcgtctcggc cctggtctac gccctgtgga cggtcgtggg
     1861 cgtcgtcctg cacggcgcgg acacccccgg ttacgccacc ctcctcaccg ccgtcgtcgc
     1921 cctcagcggc atccagctgg tgacgctcgg ggtcatcggc gagtacgtgg gccgcatcta
     1981 ccacgaggcg aaacaccgcc cgccctacgt cgtgcgggag accgacgcga cccggcgggc
     2041 gctgccggcc ggcccgccgt cgcgcccgcg actcacggga ggcccgggcg aacgcgccac
     2101 gccccccgcc ccggccgcca tggccgaagc ccccgccccg gcccccgcga ccggcgcccc
     2161 cggccggtcc cgtaccgccc gccagttcgg cagcttcgtc ctcatcggct gcgtgaacac
     2221 cgccgtctac ctcgggatct acgcctcgct gaaccgctgg atcccgtacc tgaccgcgca
     2281 cgtcgtcggc tacgcggtca gcatcgtgtg ctcgttcctg ctcaactcct acgtcacctg
     2341 ccggacgcgg ccgacctggc acgggttcgt ccgctatccc ctctccagcc tggtcaacct
     2401 ggtggcgtcc ggagcgctgc tctacggggc ggtcagcggc ctcgggatgg acaagaacct
     2461 cgccgcgctg gcggcgggcg tcctcgtcac cccggtctcg ttcctgctgg cccggtgggc
     2521 gatcacctcg ggccggtcca gggccgccac ggcggtgccg caggccggac cgcaggccgg
     2581 ccgtccggtg cccggaccgc tgcccacccg ctcgtcccag gaggggtgac gtccgcgatg
     2641 tccgacgacg ttcccgtgac cgccgccccg gagaagccgc ggaggggcga ggagacgtcg
     2701 gacccggctg ccgggcgccc ctcggaccga ccctggaccg ccctctgggt gagcgccctc
     2761 gcgctcccgc cgctcgccct gctcgccgcc gcgtcctggt tcgggcggtg ggtgcggccc
     2821 ggcgcggacg actggtgctt cctgcccgcc gtacgggacg acggcgtcat gggcctcgtg
     2881 gggaagttct acttcgacga caacgggcgg gtcgccaacg ccctcctggt cggcgcgtac
     2941 gcgaagttcc aggtcgcggg acaccagtgg taccccctga tcagcggggc cctggtgctc
     3001 gcggtcctct gggcggtggc cgtcctggcc ctgcgccggg cccggctgcg caccccgcgc
     3061 ggcctgccgc tcctgctcgc ggccctgagc accgcgctct tcctgttcgt cacgccgaac
     3121 acgtacaaga cgttctactg gcccgcggcg tccgtctcgc acaccctgcc gcccgtcctg
     3181 gcctgcgccg cgctgatccc gttcctgctc gcccgctccc gccgggggcg ggtcctcgcg
     3241 ctcgccgtcg cggcgctcat gggcgccttc ctcgccacgc tgtccgagga gacggcgatc
     3301 gtcgtcgtgg tggtgctcct gaccgcgctc ctgctctccg gccgggtcgt ccccgccccc
     3361 gaccgggggt tcgtccggcg ctggtgcgcg gcgggcatcg ccgggacggc ggccggggcc
     3421 gtcgtcctca tcacctcacc cggctccacg cgccgcaggg accggttcgg cgcggagacc
     3481 acctccctgc tcgcccccga ctccctcacc gcgtcgctgc gcgcgttcgc cgagatcgcc
     3541 gtcaccgtgg ccacgacctg gcagtacgtc ggcgcggtcg ccgcaggcgt cctgctgggg
     3601 ctgctgtgcc gacgggcgga cgggacaccg ccccgcccgc ccgcccacgt gcccctgctc
     3661 atcgccgccg gagtgctcgc gctcctcgtc tccggctacc tctgcacggt catcgcctat
     3721 ccggtgttcg gcgaccgggt gagcgacccg ggcgccaacc ggctgtggaa cgactacctc
     3781 ctgctgtacg tgatcctgct cgtcggcgcg ggtgccctgc tgggcatggc cctgcgccgg
     3841 cacccccgcc gcaccgcccc ggcgaaggcc gtgtgcgccg cgctctgcgt cctggtgtgc
     3901 gtcggcccgg ccgtggcgct gaccaacctg gagaccgcga tgcgggcccg ggccgagaag
     3961 tgggacgccc aggaccgccg gctccgcgag ggggcggagg ccgggaagcg ggtcctgccg
     4021 tacgagcgcc tggtgatcag caacatgctg gagccgttca gccagggcgg acgctcgtac
     4081 tggcccggag gctgcgtcgc cgacctctac gggctcgacc gggtcacgga cgggaccagg
     4141 gacgccccgt gacgatgact caggcgtacg tgtagaactg cgtgtggtcc agcatgtcct
     4201 gcggggtggt gttgggccag ggcggcatgg tctcgttcag gtcgatcaca tcgaccgtcc
     4261 ccccggcggg gaggtactcg gcgctcgtcg ggtggagcgc gtgccagtcg gcccagagct
     4321 tgtcgacgaa cgagtggtgc agccagaaca ccgggtcgtt cggggagacg ctcgtctcca
     4381 tgtggcccca gacccaggtg tgcacccggt tgtgcatgct catgtacccc gcggtgccct
     4441 ccagggtgga gcggaagccg gccgagccgt cgcggaaggg cggagaatcg taggtgggca
     4501 tggcgagggc cgcgtcgacc tcggaccggg gcgggagcgt gggaacgcgg taggcgagcc
     4561 ggcgtgcgag gaaggggcgg ctgtcgaccg agacgctgat cgtccagttc ccgccggaat
     4621 acgcgaaggg gccgtccatc acctgatcgt ccaggacgcg tccggtgccc ccgaggaagt
     4681 ccggggccca gagcgaggag ccgacggtgt tgtcggcggt ccagtcccag tagggaatcg
     4741 agaccgaggc gtcgaccttc tgcagttcgt tctcgaaatc gatgaggaac ttgcggtgcc
     4801 agggcaggaa cgacggcccg aagtggccca cgtacacgcc ggagttcatg tctatcgaga
     4861 accgcgtgag gtgggtctgc acgaatgtgt cgtacacccc cgtgcgtttg acctccagta
     4921 ccgcgtcgac aaaggccttc ttctcggggg ccgtgaggtt cgcctggttc ttccgtacgg
     4981 tcatggctgc tgctcccggg tcaggcggtg gggtcgaacg gaacgatgac ggcgcccttg
     5041 agcgagatga ccgccgtgcg agcggcctcc agcggggtcg cgaagcgctc gtagtggttg
     5101 atcgtgctgc tccagccgct cttcccgtgc tgcatgacgg gcagttcacg gccgtcgatc
     5161 agcacgcggt aggcaccgtg tccggcgtgt ccaccgtgtc cggcgtgcgc gtgggcctcg
     5221 gtgggcgtgc cctggatacg gcggcccttg aagacctcat cgaaggaacc gggtgctccg
     5281 gtcccgccgg gtgtgcggtc gttgctcgtg gcctcggccg ccacggtctc cgtggacgcg
     5341 gcggccatac cgacgagcgc tccggttgcg gcgacgccga tgacggctcc gagggcctga
     5401 cggcgagtgg gtttgggcat gccggatgta cctccagaac atgagggagg cggccccccg
     5461 ggtggtgtcc ggggccgccg tgatcatgtc tacacggggg tgaccgtccg cataagcagg
     5521 gaaaaagagg ttggctctca tatggacagg tcttcacgga cacagggggg acagagagtg
     5581 tccgccggcc tcccgtgccg cttcgcgccg gtgcttgagg cgtcggaggg cgcaggtctt
     5641 gccgcgtacg tgccctgcca gtgaaggatt tgcgatatcc gtcgcgctgt cgcccaccgg
     5701 aacgatcatc tgcgcatggc cggaagtacc tgaaggtcgg caccatcacg gtcgacaggc
     5761 cggtcgtcac caactggcac accgccccgg ccgacgccgt tccctctgcc tgagagaact
     5821 gacgcggggc cggggcgggc ggaccggttc cgttcctcag tacccgtaga tcatcttgta
     5881 cgcgacctcc ggcaggaact gcccggccac ggagccggcg ccgactccgc agtcgccgtc
     5941 ggactcgccg ggggtcttca gccacagcag catctcggcc ccgccgcccg tctggctgac
     6001 cgcccccgtc ctgcgcccgc ccgggttgca ccacgcgccg ttggagccgt ttccgttgcg
     6061 gctggtgtcg atgacgtacg gcttcgtata gccgtaggac gccgccaggg acccgttgac
     6121 ggcgttgccg tacgcggagt tctcgccggt gccgtagtag ttcgagacgt tcagtgagaa
     6181 gccgtgcgcc tgccgggctc ccgcgccgtc gaggtgttgc gccatggtgg ccgcgccgat
     6241 ccaggccggg tttccggcgt ccagataggt ccaggtgttg ggggcgtggg cggcgaactg
     6301 ggcgagcgcg tccttgagca ttccgttgcg ctcgtcgatc tgagcctggt tcaggcagct
     6361 gaagtcgccc agggagtcgg gctcgatgac caccagggcg ggccgcgcgc cgatggccga
     6421 ggcgaacgcg gagatccagg tgcggtaggc gctcggggtg cccgcgccgc cgccggagtg
     6481 cccgccgcag gcgtcgcggc cggggatgtt gtacgcgatc aggacgggca gcttgtcggc
     6541 ggcgtcggcg gcgcccacgt aagagccgac cgcagccccg atgtccccgc tccaggagcc
     6601 gaaccagcgg gccatggggc gcgaggagat gttgtcgcgg atggcggcgg cccgcccgtc
     6661 tccggggttc gccgcgaccc aggcggcggg cgtcgagtgc gggtcggtgt agaagccgtc
     6721 ggtcatgccg atcgggtcgg ccgacgtggt ggccgccgtg gcctgctgcc cggtgccgag
     6781 gggaagcagc agacaggcga acgccgatac ggcgagggtg cgcaggagtc ttctcatgcg
     6841 tgcggccctt ctgtgggagc gctcccaacc gacgacggcc gcgcaggtga tggggggtgg
     6901 gagacgcgtg aatgggggga aggcgcgtgg ggcggtggga agtgcgtgcg gcgggccggt
     6961 ggggcttcgg tccgcgactg ccgtcgtcag acgagacggt gacagcgggg cgccccgctg
     7021 tcaatgagcc cggagcagcg gctccccggt gcggggcctt cggggaaccg cgaccgtgtt
     7081 cagacggcgg gccggtggac gcgggggatt cccaggtccg gcaggtcgag gtggaagccg
     7141 cgcccgcgac cggtcgtggt tccgtcgtag gagaggtcgg ccaggccgac gcccagatgc
     7201 cggagttccc cgacgagcat gcgggcggcc gtggccgcgt gcgcggggtc gtccatggcg
     7261 tcggggaagc ggcgctgcca gaccgagggg gaggacttcc agccactccg cgccagccgg
     7321 tcggggtcgg ccgcgtccgg ttggtgcaga tagccggtgg cttcgatgac gagacccaga
     7381 tcctgactcc agccctggac gaagcgctgg ggatcgtcgg cggatcccag gtgcaggatg
     7441 aacctgccgg ggaagaacgg ggtgtcgtag tcgagggagc gcagagtctc ggacaggtgc
     7501 ttctccacct cgtcccacgt ggtgccggtc gcctgcgacg cgacgggcgc gctcggcgga
     7561 ccggcggggt cggcggcgcg ccagcggcca cgggaatagc cgcgtccggc ggcgtcggcg
     7621 tccgcgtcgg gaggcaggag ttcgaggctc acctcgccct cgtcgtgcga gtgcacgagg
     7681 aggcaggcgc cggggagccg ccacagcatc cacgggccgg agtcgcctcc ccacatcgcg
     7741 ggcgggccca gctcgtcctc catgacccac caggcggcgc ggacgagacc ggcggcggag
     7801 gctgtgtcgt cggcgggcag gtcgacgacg cgtacgttca gtttgcgcac ctgatcgggg
     7861 gccgaggcgt cggagatcac cgtgccgtag ccgctccggg gccccttccg gggagcgaac
     7921 ctgcgccaga cctggcccac gatctccttg ggctcccgga gctcccagcc cagctccgag
     7981 gtggcgtgct cgaactccga caggctccac gagccgaagc ggagcgggat gacctcgcgc
     8041 accagctcgc ggaaggtgtc gtcgccgagc caactgcccc gggggatcat gttctccatc
     8101 cggcagacag tagtggcccg gtgccgacgc gattccgggg gcccgatgtt gacggaccgc
     8161 tgcccgggag gcgacgctca ccgcaccagg gatgagaggt gggacatgga ggcacacgcc
     8221 tcgcaactcg cgttcggccg gcaggttctg gatgcccagc ccttcagcgt cctgctgggc
     8281 gcgcggctga cggccttcgg tgacggagcg gccgtcctgg agctggacgt acgggacgaa
     8341 ctgcgccagc agaacggctt cgtccacggc ggcgtcctga gctacgcggc cgacaacgcc
     8401 ctgaccttcg cggcgggcgc ggccgccggc ccgtccgtcc tgaccgccgg tttcaccatc
     8461 gactatctgc gcccggcccg gggcgaggtg ctgcgcgcgc gggcccaggt ggtccgcccc
     8521 ggccgcaccc gggtcgtctg ccgctgcgat ctgctgatgg tggacaccgc agggatggaa
     8581 accctctgcg cggtggccca gggcacgatc gccgtcgcct ccggaaggcc gccggagccg
     8641 accgcgaccg ggtgaccccg gtgtgcgcgc cgccgaactg cccccaccac gtgccgcccc
     8701 gctcgcccgg tacggccttc gcccgctgtg ctccccgtcg cccgcccggc acggcgaaga
     8761 caagagcccc gacccccgag agagggccgg ggccggttga ggagcccggc cgcctacgcc
     8821 ccgacggggc acggagtgtg cggctcagct ctgttcggtg aacaggtcac gaccgccaag
     8881 gacaagtacg acggccgtgc gagatagatc ccccacgaca cgtcaccacc ccatgacagt
     8941 cgctccaacg ccccggccac gcgcgtggac aggtggtccg gttcccgctc ctgccgggag
     9001 tcgaaccggg acgcgtactc cctcaacctg tcgtcgagcc atgccaccgc tccctgcggt
     9061 tcttgccacg taccgcacac gagagcggca ggcttcagca accaatgcgc ggtccgcacc
     9121 ggcggcacgc cgcccgtacg gaattctgct gcggcctcgc ggtaccgctg atgcaaacgg
     9181 tgcccgtcct tgtcgtcctc gcccgtcggc gggggcggag gatcgtccgc aggcggacgc
     9241 ctgtcgcctt cccggtcgaa gacttcccgg gaaccggtcc agaggtaccc atggtggtgc
     9301 aacggcgctc ctgatccaat gtgttgacgg agcggctcag gccagaccga acgcggcagg
     9361 ggtgatgccg gccgcgtcca gctcggccgt ggtgaacctg agcggggtcg cgtcggggcg
     9421 cttggagtcg cccagggccc acgcgtcatc gccgatacgg gcgagagtga cgcaggactc
     9481 gccgtccggg tgagtgttgc cgccgcacgc cttcgtgaac cgggcgctgc tgatgtcgag
     9541 tgcgtacagc ttcttgccgt cgatcatgcg cgtaccttcc tgatcggttg accggcccgg
     9601 ggtggggccg accgccgcct cgacagggaa tcggggcggc ttcctcatgg agctcatccc
     9661 ctgaggacgg aagtcgtcac ggattatgcg cgtgatggac taaagatcag tttcggaatg
     9721 accaagccca ctgaatcaac aactcctgtg cggcgtcgcc tgtgacggcc tggccttcgt
     9781 agaacgcgaa tcggtcgagg agtgagcgaa cgtccctggg gtcgcggaat accgctgtgc
     9841 cgaggtccgt ctcgatggtg gctaggcggt ggtcgtacac ggtgaacgtg gacaaaggtg
     9901 tactgctgta tcggaccgac aatggaagca gtgcaatgct gatattggct tggcgggcga
     9961 gtgaggatat gtggtcgatc tgcatggcca tggcgtccgg tgcgaccagt gggtaccgga
    10021 ccgcctgttc cgtgaggatg aatgtgaatc tcttggagcg gtcgagtagg accgcttggc
    10081 gttccagctt catgcccacg gctcttgctt gttgcgtcgg cggagcgtca aggatgcttg
    10141 cccggatgta ctccggggtc gaaagcaagc ccgtcaccat ggacaggagg aagaaccgaa
    10201 aatcggtggt cgcggcctca aggccggcca gctcaagttg cttcttgtcc aaccccttac
    10261 gatgcagtgc cttgcggtcc tgccactccg tctgagcaat acgcgccatg gccattactt
    10321 cggcggctac cgctggggat gcgcagagcc ctttgaggat ctgctccacg tccacgagtg
    10381 acgggcggac cttgttgccc tcgatgcggc tgaccttgga
//
