LOCUS       NZ_CP117709            28889 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 chromosome, complete genome.
ACCESSION   NZ_CP117709
VERSION     NZ_CP117709.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8003288)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8003288)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5355575
            Orig. end                         :: 5384464
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117709.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..28889
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="20"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..28889
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28889
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:18889](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18889
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    139..154
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.54"
                     /tool="antismash"
     misc_feature    478..493
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.28"
                     /tool="antismash"
     gene            complement(842..2149)
                     /gene="rfbH"
                     /locus_tag="PSQ21_RS24015"
     CDS             complement(842..2149)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rfbH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446985.1"
                     /locus_tag="PSQ21_RS24015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipopolysaccharide biosynthesis protein RfbH"
                     /protein_id="WP_274032877.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.9e-96,
                     bitscore: 320.1, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHEHRERALEEARKHHQSVRGSGEFVPGTTEIWPSGAVLDEDDR
                     AALVEAALDLRIAAGPLSKRFESGFARLLKRRKAHLTNSGSSANLLALTAYTSPLVGER
                     RLLPGDEVITVAAGFPTTVNPILQNGLVPVFVDIELGTYNTTADRVAAAIGPKTRGIMI
                     AHALGNPFEVEEIAQLAAEHNLVFVEDNCDAVGTTYRGRLTGTFGDVSTVSFYPAHHLT
                     MGEGGIVTTSDLKVARIVESLRDWGRDCWCEPGHSDTCLKRFDHQLGALPAGYDHKYIF
                     SHVGYNLKSTDLQAALGLSQLRKLDGFIAARRHNWRRMREGLDGVRHLLLPEATAGSDP
                     SWFGFVMTVGPDAPFTCGELTGFLEKRKIGTRRLFAGNLTRQPAYLRQPHRVVGELTNS
                     DIVTERTFWTGVYPGLTDEMTDYVIASVREFVAGRR"
     gene            complement(2146..3138)
                     /gene="rfbB"
                     /locus_tag="PSQ21_RS24020"
     CDS             complement(2146..3138)
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-187). E-value: 7.1e-19.
                     Score: 59.8. Matches aSDomain:
                     nrpspksdomains_PSQ21_RS24020_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446986.1"
                     /locus_tag="PSQ21_RS24020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_274032878.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-24, bitscore:
                     84.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.2e-18,
                     bitscore: 64.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 8.3e-17, bitscore:
                     59.8, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFVGSHYVRTMLAQGYPGYERADVTVLDKLSYAGNA
                     ENIPLGHPRLHLVKGDVCDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVG
                     TQTLLDACLNAGVERVVHISTDEVYGSIAEGSWHEESPLLPNSPYAASKAAADLTVRSY
                     WRTFGLDVSITRCSNTYGPYQHPEKAIPRFTTNLLEGEPIPLYGSGRNVRDWIHVDDHA
                     RAVQLVLTKGSAGGIYHVGGGHELTNLDLAEHLLALCGADRSMIRHVTDRKGHDLRYSL
                     DGSKARTELGFTPRVGFDEGLAATVDWYRENTAWWKAAKDQAGDEESRA"
     aSDomain        complement(2578..3126)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PSQ21_RS24020_NAD_binding_4.1"
                     /evalue="7.10E-19"
                     /label="PSQ21_RS24020_NAD_binding_4.1"
                     /locus_tag="PSQ21_RS24020"
                     /protein_end="187"
                     /protein_start="4"
                     /score="59.8"
                     /tool="antismash"
                     /translation="VTGGAGFVGSHYVRTMLAQGYPGYERADVTVLDKLSYAGNAENIP
                     LGHPRLHLVKGDVCDAPLLNELLPGHDAVVHFAAESHVDRSLDAPAVFTRTNVVGTQTL
                     LDACLNAGVERVVHISTDEVYGSIAEGSWHEESPLLPNSPYAASKAAADLTVRSYWRTF
                     GLDVSITRCSNTYGPYQHPE"
     gene            complement(3135..4202)
                     /locus_tag="PSQ21_RS24025"
     CDS             complement(3135..4202)
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446987.1"
                     /locus_tag="PSQ21_RS24025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_274032880.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-12, bitscore:
                     46.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLAGGLGTRLRPFTETMPKQLIPVANQPVLEHVLENLRALD
                     VREICVVVGAWGPDIAARIGDGSRFGARITYLTQLRPLGLAHCVALARPFLGDDDFVMY
                     LGDNVVEDGIAGPAEEFRARRSDAHLVVAKVADPRAFGVAELDARGRVRRLVEKPRLPL
                     SDLALIGVYFFRPAIHRAVAAIAPSARGELEITDAAQWLVDRGAPVTAGEYTGYWKDTG
                     RVEDVLDCNRRLLGTLARGIHGTADAASRLTGPVHVAPGATVLRSVITGPAIIGPGSLV
                     EDCRIGPGTSIGSGCVLRDTELENSIVMDDAWVTGRTGASDLLIGRAMRIGSGPPPVPL
                     PQELAANGARTGGTR"
     gene            complement(4339..5490)
                     /locus_tag="PSQ21_RS24030"
     CDS             complement(4339..5490)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (33-160). E-value: 1.3e-11.
                     Score: 36.0. Matches aSDomain:
                     nrpspksdomains_PSQ21_RS24030_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446988.1"
                     /locus_tag="PSQ21_RS24030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DegT/DnrJ/EryC1/StrS family aminotransferase"
                     /protein_id="WP_274032881.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.2e-89,
                     bitscore: 298.4, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.6e-06, bitscore:
                     26.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 8.1e-09, bitscore:
                     33.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVFQPSLGEAELLALSEVFASNWLGHGPRTAEFEARFADHLGV
                     EPDRTLFLNSGTAGLFLATELLDLGPGDEVVLPSVSFVAAANAIAVTGARPVFCDVDPH
                     GLHPTAEHVESAMTPRTKAVIVLHYGGYPGEVAEIAALCRRRGVPLVEDAACAVASTAG
                     GKACGTFGDIALWSFDAMKVLVTGDGGMLYVRDPQLARRARVLAYHGLEQPSGFGHAKV
                     SERWWELDVRSFGRRVIGNDLTAAIGTVQLGRLPANVARRREVATAYDSLLADTPGVRL
                     PPPLPEGHRSSYYFYWVQLDPLIRDRVAATLLAQDIYTTFKYPPLHRVPAYGAHSTDLP
                     GTDRATDSTLLLPLHQALSDAETRTVANALREAVTHHLALAGA"
     aSDomain        complement(5011..5391)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PSQ21_RS24030_Aminotran_5.1"
                     /evalue="1.30E-11"
                     /label="PSQ21_RS24030_Aminotran_5.1"
                     /locus_tag="PSQ21_RS24030"
                     /protein_end="160"
                     /protein_start="33"
                     /score="36.0"
                     /tool="antismash"
                     /translation="EFEARFADHLGVEPDRTLFLNSGTAGLFLATELLDLGPGDEVVLP
                     SVSFVAAANAIAVTGARPVFCDVDPHGLHPTAEHVESAMTPRTKAVIVLHYGGYPGEVA
                     EIAALCRRRGVPLVEDAACAVAS"
     gene            complement(5536..6840)
                     /locus_tag="PSQ21_RS24035"
     CDS             complement(5536..6840)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF044385.1"
                     /locus_tag="PSQ21_RS24035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_274032882.1"
                     /sec_met_domain="MGT (E-value: 2.5e-114, bitscore: 381.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFCTWPAAAHLYPSVPMARALGDAGHEVRVVSHPSLLDTINA
                     TGLTGVSLSDEETLPQPLGAGRPIAPDTYADLVSLTKSLDLDSYGRYVWTYFRDYMLPA
                     IRDFQPERAPADAPQYALDALVGLCRSWRPDLVLWDPTMPAAGVAAQVSGAAHARILWG
                     PDLFGWAHEQYTRCAKLSGDALLPEEPMTSSVRPMAERYGLPLTDELLFGQWTVNPVLE
                     RMRLPTRKRTVSVRWQPYAGPAVLPDWLREPPARPRVAITLGSSIRAWGRDSALLVNRV
                     LEMVDGLDVEAVATLDASQLAVADRIPDNVRTVDYVPLTELLPTCSAVIHHGGHGTFGA
                     ALVNRIPQFVVMDPGYPMEAPLTGRFLSESGVGTGVRVDRHTGAELRAGLSRLMTAPSF
                     RDAAAELYTDLLTAPEPGEIVPVLERLTRHHQSRD"
     gene            complement(6863..7513)
                     /locus_tag="PSQ21_RS24040"
     CDS             complement(6863..7513)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446992.1"
                     /locus_tag="PSQ21_RS24040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_274032883.1"
                     /transl_table=11
                     /translation="MSEPSDQIAGVGAREQPADSGVEVFERHYAGAPGAGWEINRPQTV
                     LVRLAEEGALRGRVLDVGCGSGDNALLAAEHGLETTGVDAAPSAITLAARKARERGLKA
                     RFLEWDALDLASLGEQFDTLIDVGLFHCFAPEDRPLVARSMASVVPPGGRCFLMCFSDR
                     QPGTWGPRRVPEQAVRESFTDAGWRVDTLEAAELDVAFNPGTAQAWFAAMTRL"
     gene            complement(7805..8542)
                     /locus_tag="PSQ21_RS24045"
     CDS             complement(7805..8542)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451958.1"
                     /locus_tag="PSQ21_RS24045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_274032884.1"
                     /transl_table=11
                     /translation="MDTPQIPSTVYSTEHAEIYDFVHAARGRDWSAEADGIARMIRERC
                     PEAGSLLDVACGTGAHLERFAGHFGTVAGVELSPDMRETATRRVPAARVHEGDMRQFDL
                     GRTFDAVLCMCFSLGYMSTVGELRRSAATLVRHLAPGGVLVAEPWWFPERFIDGFISAS
                     LAQEEGRAVSRLSHSVRDGRISRMTVRYTVAETSGIREFTEYETYSLFTQEEYLDAFEQ
                     AGCAVEFLPDWPNGRGLFIGVRA"
     misc_feature    complement(8764..8780)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    complement(8850..8863)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    complement(8858..8873)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            8859..10004
                     /locus_tag="PSQ21_RS24050"
     CDS             8859..10004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451957.1"
                     /locus_tag="PSQ21_RS24050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274032885.1"
                     /transl_table=11
                     /translation="MITDTAAAGPEMSEAAGVRLYSRVPITPRWLARNVLPVSRRLRED
                     RQAALLHLRRGWLYGPHVDIVARSVPGRPALDWAGIATGLDAGPAEGPNVMDEETYLAQ
                     ARETGRLEGVAPPYLPMREHGVTEALSFASVETWPQPLQDLREMALDQLDLPLTMTVER
                     LAEEPREAPVRLMEAFIALAAAHQYGAGNGAFSMRSHAEAFFAWAATRKDPRPAFAQRL
                     AADAPRLRPVVERALSGTPDHGTAAWARAFAYSMGAFDATVAQGKLTLDDIDGLGGGFD
                     LDTMGPPGGDGRVSHEPSAFHRTMDESGVIASPPKWFASYRLLVNLFYQQLPLLGVPPM
                     HRYYFCFAVAELVDDVLGSSWEDRLEQTRQEMAQATAGAAE"
     gene            10001..12544
                     /locus_tag="PSQ21_RS24055"
     CDS             10001..12544
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451956.1"
                     /locus_tag="PSQ21_RS24055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274032886.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.8e-11, bitscore:
                     41.6, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTAEPLWMLRLNPLRRRRLADPGLLAALRTLDGATTEVRELAG
                     QCSDVLYELIGAATDRQARGQLIVLRRAIHNDTAPRPALLVDHPLVGRWWEARQRRETL
                     AADVVGRYPGAVDAERGTLAGLLGDESLRHSMTLVAPDAAAGAGRYVAAVAAAEPVPTR
                     LRKSERGLVQYVTRAMIRTSPMARFTAIGLAVPEPHGPGPDAPEFGRVVPFQGLDRVML
                     DYVLGGLHTSDGEITPDTLLQLPPTSDLSAEGDLLYFLRPGADGGVRRLSAKVTGAVGL
                     LVAAVAVGPRRAADVAAGFAARSGCTPELAWQALARAVGAGILCTRSRPEDGAADFPDL
                     LDPAGHSVPETARRLLERTGAELRGLADNSADERPEAMSRLRATLAELSREAGRPAQIL
                     IEEDAVLEDVRLSTADWRGQLDDLAAGVALLSVFDWMHDIRALLSAVFVERFGVGAEVS
                     LSDHADYLSTETYRRAYRLPEKAPPGELGPADRSLDRLYTLRANVVDTAIAAVDRAVAT
                     GEAVSWSASQALDLTTGLPDRFRTGDLRYGVLTQTWQRRLLFNEAYAGHGMLYGRFLGP
                     DRALGGRALPHFREQLRARYAEHDGRLAEDLGLHRLNVNAHPPVLPDRLGPDDWFRLRL
                     RHDPDTDTLGIRDPDDRPLHVLSLGTGHPERLPAPLRLANWLYSGGVLREPFMAIRHGE
                     QQWDGVGTLACPRFQVGSAVLARRRWYGGRELDEAVAAGPAEHDRLLALARWRNRHGVP
                     EEVVLKPPPDDGTGEGRTTGEGRSAGEGRKKKPQYVDLASALSVRVLPRMVERGEAAYV
                     EEALPRVADSPHALEWIVDIGRAPGGPFQYGGKTR"
     aSDomain        12541..12786
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PSQ21_RS24060_Thiopeptide_F_RRE.1"
                     /evalue="9.50E-11"
                     /identifier="RREFam004.1"
                     /label="PSQ21_RS24060"
                     /locus_tag="PSQ21_RS24060"
                     /protein_end="82"
                     /protein_start="0"
                     /score="32.5"
                     /tool="antismash"
                     /translation="MTLRARPHLHYAPVSEGLYINGPRTQFVISGPQLLYRVADTCVPL
                     LEAGTTEDELVTALGSERARPVVRRIVEELRARGLLL"
     gene            12541..14364
                     /locus_tag="PSQ21_RS24060"
     CDS             12541..14364
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PSQ21_RS24060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_274032887.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 2.4e-08,
                     bitscore: 32.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRARPHLHYAPVSEGLYINGPRTQFVISGPQLLYRVADTCVPL
                     LEAGTTEDELVTALGSERARPVVRRIVEELRARGLLLDLDALTVPEPSAEIRARYPEAL
                     AHLETECADPYAVFQRLRTTEVLLCGPADAVLPAARGLHRAGVTGLTLATPDPDAAAAT
                     ASRLGMRLLPLGGTATLPDPAELPVPPDAALYCPGADDGETPRALAALLPAGAPVVPVR
                     WDGLVAAVGPVSPGGASLPGSAALVRRAAHWAVAEATAPAPHPTAAALAGALAGQLLFD
                     TLAGIAPPGEAHVLHGEELTADRVSVSLTAPGPTAGEAAERSFLTAAPAAGAEPVVPPT
                     PDEAVEAVTALTGRWTGPVALLAGEELPQMPLALREMAARDGGTDSVVAWAEEQRTATV
                     AVALAALRAACPSPGAAAAGLTEEHWLLDGALRLMADEAVPYATRTVGAVEAHSVPLLR
                     MLEEEGMPDPAVTLLRHPGLDWTLAEVRVSGGPRPWTGVSWGRDDTEAVHRALATALAR
                     HQTHGVPGAGPLADGVHTDALLFADAAEQAALRKRVADSAAAAGLRYEGTPRRPDPVTG
                     ALPLWSGTVRAVPLAGEPQVTEASTEEPDRG"
     gene            14357..16288
                     /locus_tag="PSQ21_RS24065"
     CDS             14357..16288
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451953.1"
                     /locus_tag="PSQ21_RS24065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_274032888.1"
                     /sec_met_domain="YcaO (E-value: 1.2e-64, bitscore: 217.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENPTTVVCAPALSDATDTDWRVVLEPLGAFGDGTVGVNLGWDL
                     AWERDRLRSAGEREHLSVRVYGDEVLVGPRWVPGTDSGCAGCAELRSRLVIDHPLTDDL
                     TRPTARVAPRRPFLAELTRAALARLADRPLGPGELYAVGSRGTRTHRVPRHFACPLCAP
                     EIPERPVGRPPEPLALRPRPAAADNPGRAAAGAALVRPGALRSRLVDPRFGPVLAQQRE
                     LLAPFAMSMALQPDAVALGYARETTFAKADPIAILEVYERLSGFPHQAPLVEGVSYADL
                     VAAEGGAEVAVRPAAFGEYTEEQAARPTARIERVTDETPMDWAWGHDLADGRPRLVPAE
                     LAFFQYDYRYGREQRAARRHGAAPRRHLYQESSSGCAVGSCLEEAALYSLLELAERDAF
                     LISFHRARPLPEITHSSITDPVARGLLATAASRGFRVHLLRATQDIDLPVVWAMAVNTR
                     APFPATFSAAGSGIDPVSALRGALWEVTQMATDRLTWDRSEAEPMLADPWLVDEMDDHL
                     RLYALPEMKERVTSVLGGPEMSLSEAFEGWPDRLEQAAGGDVLGALDYIRGRYAAAGLD
                     RIVLVDSTTRDHADIGLAAAKAVVPGIVPMCFGQAQQRVAGLPRLEAALAGTPSGDLSP
                     PYEPHAFP"
     gene            16371..17855
                     /locus_tag="PSQ21_RS24070"
     CDS             16371..17855
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553604.1"
                     /locus_tag="PSQ21_RS24070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274032889.1"
                     /sec_met_domain="PF00881 (E-value: 3.4e-05, bitscore: 22.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSDRGGPASPIPDDADVMSRDMRWFTYATGLGVRVEPAAVPE
                     PRPDTEVAPALPEAALGDRTPLPRGTAELLERAPYPHGRAGAPRERADALGHALVAGFG
                     LQRREPENPFNDHRPYPSVRAKFPVQVFVRDGRHRRVLDLYRHALTGVGRQDGAAGPLE
                     VALAGRYTRLPDSYRWFRSSLIGLELGVNLRQLCLGLDLFGLSGKLRLPDRDAAGLLTD
                     FGLTPESEWSLPLTVALEDGGPPAAAPPAERAADPVLDGILTVNRSQDFTGPSAPLGPS
                     VPAGLPRDGTLSWAEVLWRRSAGRMPRGMYGMTGRRRPVPERTLREAVSWLNVPPPGPH
                     LAAAWEELRLTAVFQGIEGHADGVWHLRDGRPVLHRAQPGAASVLEEHYGYPVTPYAGG
                     DVRHASVVWFLSASPRRLVERLGPGGFTAAQYAAGWAAQGISLAAAATGLYARPARAFQ
                     EVPTKQLLGLDAEEMIVCAAITGTPRFEGLLCDLRL"
     gene            17870..18889
                     /locus_tag="PSQ21_RS24075"
     CDS             17870..18889
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036322.1"
                     /locus_tag="PSQ21_RS24075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_274032890.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-37, bitscore:
                     128.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTSETARAGDGDTGSGTVWRTWHLHVSSGDRSVHDRVLVEAVV
                     PLIHTLPDRPWFFLRYWHGGPHVRLRVGDLTDEQAASAERLLAERLADAGRLREGETAM
                     SPADYARTASSMTTAGDQPSHQEVTGMLEPGVHRFAYHPEYERYGGRELLPESERLFEL
                     SSRLVLSFLRRGPSAGARALLALRATVCAGRALGDDPAEEAAFYDHGLRAWRTWAAGYG
                     YTERQLDELYRAARPTDELRAKVAGGDTAGPLAPWQAALTGLSDRIRRETPLHPAQVTV
                     SHVHMLHNRLGLRAVEEYQTYARLARLFPVRSAPEGAPPSDHSGPAQSGAVLTPEEHR"
     gene            18886..19803
                     /locus_tag="PSQ21_RS24080"
     CDS             18886..19803
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451944.1"
                     /locus_tag="PSQ21_RS24080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219611990.1"
                     /transl_table=11
                     /translation="MSTSPTTATARAGAPPTPAVIARAIGVTRHYGDTVALDNVDFTVR
                     EGEFIGLLGPNGAGKTTLLNSLLGLRKPTSGRIELFGGSPTNPASRRFIGVTPQESGVP
                     PTLRVAEAVDFVAAHFKETEDRDELLERFDLTKEARRQTGGLSGGQKRRLALALAFVGR
                     PRLVILDEPTTGLDVESRRMLWDRIREFHEGGGTVLLTTHYLEEIEALAKRVVVIAQGR
                     IRADDSVGAIRGMAHMQRVSMNAGPLPDLPGVISEERTEERVELMTHDADQLVRALVRQ
                     GVEFSGLAVQQATLEEAFLVISQS"
     gene            19837..20577
                     /locus_tag="PSQ21_RS24085"
     CDS             19837..20577
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451942.1"
                     /locus_tag="PSQ21_RS24085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_274032891.1"
                     /transl_table=11
                     /translation="MSSLTLVHARYQLVELSRIPMAIIGAAFFPAASLIFFVVPNTKDD
                     PVGATLATASMVVFAAMISNLFGHGTGVAEDRSQPWDPYTRTLPIGPAVRFGSRIITGL
                     AMMLFSMVPVVIVAAFFTPATLSPARFLLAIGVVILVSVPFTMMGLAIGYLLSTKAAIA
                     TVQLVFLPLAFAGGLLAGPGEAPGFIEAIAPFVPTRGSAELMWATVGDYDINPVAIVSL
                     VVWTAGLAALAFYAYQRDEGRRYH"
     gene            complement(20620..22257)
                     /locus_tag="PSQ21_RS24090"
     CDS             complement(20620..22257)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019074884.1"
                     /locus_tag="PSQ21_RS24090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional
                     3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
                     hydroxylase"
                     /protein_id="WP_274032892.1"
                     /transl_table=11
                     /translation="MNGISGSRDRSAGAPEADVLVVGYGPVGQVLAILLAQSGWRVVVV
                     ERHPEPYSLPRAVAFDAEAARTLDAIGVTGRIGDITEPSQDYVVSDAAGRQLLRIGLGG
                     SDGTGRPDSTSVYQPGLEAALAARGEELPTLRVLRGLRAVGLTESGSGAELVAEDERGG
                     ERRTFTASWVVGCDGAGSFVRRSLGVGWADSGFALDWLACDVVPDRPEDFPPSNLQIAD
                     PARPRVAVSCGPGRRRWEFMRMPGEDRAEFGTEENAWRLLSMFSAGPDNATLTRHATYT
                     FRARNAEQWRRGRVLLAGDAAHQMPPFAGQGMCSGFRDAANLAWKLDLVLGGRAGEALL
                     DSYEQERRAHVQQAIDLSVRLGRLICVTDPAAAADRDRAMTAPSPGPSRPSEPARPAGS
                     TRSASPLGEPLAKGFLADGGPPAGELTGRARLTGPEGPGPADSVLGPGFVLLCRENLAD
                     TLSPAALETLRLVRGRVVTVVRADGGPTPGPDTVLDADGHWLPWLESLPAGAVLIRPDR
                     YLFGAAPDADGLAALLMEFGRRLRRATR"
     misc_feature    22382..22397
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(22430..22444)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     misc_feature    22463..22478
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.71"
                     /tool="antismash"
     gene            22498..22662
                     /locus_tag="PSQ21_RS24095"
     CDS             22498..22662
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="PSQ21_RS24095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_073740161.1"
                     /transl_table=11
                     /translation="MSMAIEAMNADALFDSFDIEELDTMEVADGVALPEMGASTGNTMC
                     CSSSSSSCC"
     misc_feature    22692..22705
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(22705..22717)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    22759..22774
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.51"
                     /tool="antismash"
     misc_feature    22760..22776
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.62"
                     /tool="antismash"
     gene            22871..23035
                     /locus_tag="PSQ21_RS24100"
     CDS             22871..23035
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547678.1"
                     /locus_tag="PSQ21_RS24100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_274032893.1"
                     /transl_table=11
                     /translation="MSKIVETMDVDAMFDSFDIEELGTMELADGVALPEMGASKGDWTC
                     CSSSSSSCC"
     misc_feature    23139..23154
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.88"
                     /tool="antismash"
     misc_feature    23311..23326
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.56"
                     /tool="antismash"
     misc_feature    23364..23380
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            23426..23590
                     /locus_tag="PSQ21_RS24105"
     CDS             23426..23590
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036314.1"
                     /locus_tag="PSQ21_RS24105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin"
                     /protein_id="WP_274032895.1"
                     /transl_table=11
                     /translation="MSKIMETMDVDAMFDSFDIEELDTLEIADGVALPEMGASYLNAPL
                     CCSSSSSCC"
     misc_feature    complement(23664..23675)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.1"
                     /tool="antismash"
     misc_feature    complement(23671..23686)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.72"
                     /tool="antismash"
     misc_feature    23684..23699
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            23800..23979
                     /locus_tag="PSQ21_RS24110"
     CDS             23800..23979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547678.1"
                     /locus_tag="PSQ21_RS24110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin"
                     /protein_id="WP_274032896.1"
                     /transl_table=11
                     /translation="MSKILGTVDADADADAMFDSFDIEELGTMEFADGVALPEMAASTA
                     HAPLCCSSSSSACC"
     misc_feature    complement(23994..24011)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.85"
                     /tool="antismash"
     misc_feature    24092..24108
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            24155..24325
                     /locus_tag="PSQ21_RS24115"
     CDS             24155..24325
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906217.1"
                     /locus_tag="PSQ21_RS24115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiazolylpeptide-type bacteriocin"
                     /protein_id="WP_274032898.1"
                     /transl_table=11
                     /translation="MRSTLETMDVDAMFDSFNIEELDTMEIADGVALPEMAASSLPHTC
                     CSSSSSSCCCC"
     misc_feature    complement(24428..24441)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.19"
                     /tool="antismash"
     gene            24441..26087
                     /locus_tag="PSQ21_RS24120"
     CDS             24441..26087
                     /NRPS_PKS="Domain: AMP-binding (23-440). E-value: 8.4e-66.
                     Score: 214.1. Matches aSDomain:
                     nrpspksdomains_PSQ21_RS24120_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="PSQ21_RS24120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fatty acid--CoA ligase family protein"
                     /protein_id="WP_274032900.1"
                     /sec_met_domain="AMP-binding (E-value: 9e-66, bitscore:
                     220.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFPIDVPDSWAGHEHYARRVLWRLARQPSLPTLYFRGRWLDGAT
                     LADAVRATVVGLRRAGLTPGGTVAVLTEPNHPAMLIGRYAAHLLGAGVVQVRSANPRSD
                     AFPLPAATQARILDGTGTSVLLVDAPHLERARALLSLTEGSPRLLGYGVGAADCPDALS
                     CRDEPLGELPAHDPGRRAVVAFTSGSSGAPKNIHQTFGVWDSTVRSAAGGEPDERRVFL
                     AVTPLSHTIGAMADAVLTAGGQVLLHQDFDAPKVLRAFEDHGVTDTYLAVPHLYRLTEL
                     LADGPGQEQGVGSGPVGDALGSLRRVVYSGTPAAPHRVAEALRVFGPVLVQLYGTTEAG
                     GISNLSPFDHLEPELLGSVGRPLPWVEVEVREPGTGRPVPRGEAGEIWVRASTVMAGYP
                     DDPELTARVLRDGWLDTGDLGHWDRYGYLRLTGRSGQVIKSGGLKVYPAAVEGALLSHP
                     AVRHAAVHGVRDPDRTEYVHAAVVLRAGRTASAEELRTHVGERLSPLHAPAEITFWDSM
                     PLNERGKPDLACLRSGNGRQAYDGAPPKGTP"
     aSDomain        24510..25760
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PSQ21_RS24120_AMP-binding.1"
                     /evalue="8.40E-66"
                     /label="PSQ21_RS24120_AMP-binding.1"
                     /locus_tag="PSQ21_RS24120"
                     /protein_end="440"
                     /protein_start="23"
                     /score="214.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RLARQPSLPTLYFRGRWLDGATLADAVRATVVGLRRAGLTPGGTV
                     AVLTEPNHPAMLIGRYAAHLLGAGVVQVRSANPRSDAFPLPAATQARILDGTGTSVLLV
                     DAPHLERARALLSLTEGSPRLLGYGVGAADCPDALSCRDEPLGELPAHDPGRRAVVAFT
                     SGSSGAPKNIHQTFGVWDSTVRSAAGGEPDERRVFLAVTPLSHTIGAMADAVLTAGGQV
                     LLHQDFDAPKVLRAFEDHGVTDTYLAVPHLYRLTELLADGPGQEQGVGSGPVGDALGSL
                     RRVVYSGTPAAPHRVAEALRVFGPVLVQLYGTTEAGGISNLSPFDHLEPELLGSVGRPL
                     PWVEVEVREPGTGRPVPRGEAGEIWVRASTVMAGYPDDPELTARVLRDGWLDTGDLGHW
                     DRYGYLRLTGRSGQVIKS"
     CDS_motif       24981..25025
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PSQ21_RS24120_0001"
                     /evalue="1.30E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="PSQ21_RS24120"
                     /protein_end="195"
                     /protein_start="180"
                     /score="11.8"
                     /tool="antismash"
                     /translation="AVVAFTSGSSGAPKN"
     CDS_motif       25578..25661
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PSQ21_RS24120_0002"
                     /evalue="2.70E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="PSQ21_RS24120"
                     /protein_end="407"
                     /protein_start="379"
                     /score="23.0"
                     /tool="antismash"
                     /translation="PRGEAGEIWVRASTVMAGYPDDPELTAR"
     gene            26084..26926
                     /locus_tag="PSQ21_RS24125"
     CDS             26084..26926
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455580.1"
                     /locus_tag="PSQ21_RS24125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_274032902.1"
                     /transl_table=11
                     /translation="MTTHQHFGRAVRLRRLFHHDPQRLLIVPLDHSLSDGPVVPRGSSI
                     DRLTGQLAGAGVDAIVVHKGSLRHIDHSRLASMSLILHLNASTAHAPDPDAKHLVTGVE
                     AAMRLGADAVSVHINMGSREEARQLADLGAVADQCDRWNLPLLAMMYPRGPKITDPADP
                     ELVAHAVTLAADLGADLVKAPCLRTRAEMRDLTAACPIPLICAGGPQRDTEDEVLAFAR
                     EAVAGGAAGVAMGRNIFQSPDPGAMAARVAGVVHNRPGSTLGHIEEGHGSELRETVLA"
     gene            26898..28007
                     /locus_tag="PSQ21_RS24130"
     CDS             26898..28007
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547674.1"
                     /locus_tag="PSQ21_RS24130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-dehydroquinate synthase II family protein"
                     /protein_id="WP_274032904.1"
                     /transl_table=11
                     /translation="MSSEKLCWLDIRSAGKARQAIVEEALHQRIDGMVAADPADLEGLP
                     PTVTKVLMPPAGKLPADYGSAQVVILAGDAAARAQAAEAAPDVEFGRLVEITDAESLDA
                     AIEAARTERWSVLEFRDPTKIPLEIVIAAAADADGAIITMAKNTEEAAVIFGCLQLGSD
                     GVLMPGRSVGDATALKATAAGGTGELQLVELEVTSVSHIGMGERACVDTCSYLGKDEGI
                     LVGSHSKGMILCVSETHPLPYMPTRPFRVNAGAIHSYTLADEGRTRYLSELRAGSKVTA
                     VDTKGRTRTVAVGRVKIETRPLISIDAVAAGGQEVNLILQDDWHVRVLGPGDAVLNSTE
                     LRPGDRVLGHLPTADRHVGYAIDEFCHEQ"
     misc_feature    28760..28775
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
ORIGIN
        1 agctgtacgg gctcggcccg cagccgggag cgggcacggg cgtcaccgag ccaggacgac
       61 acctcggcgt cggtgtgccg ggccggccgt ggccctccgg aggccggcag acaggccagt
      121 acggtcctgg tgtccatgtt gaccacgttg tccagccgca ggagctcgcc gatctgaccg
      181 agggtcagcc agcggaagtc cggttcggcg gcggggtcct cggcgacctc ttcggctgtc
      241 tccaccacga tgttgcggtt cgacttgtac aggaaccact ccccgtgttc ggactgcagc
      301 gtgtcggtca gcggccgggc gcggcccggc tcggtgaaga actccaggaa ccgcacgccg
      361 gagcccccgt gcacccgctg gtagttgctg cgggtggcct gcacggtcgg tgacagctga
      421 atcccgtccc ggttgcccgg ttccatcttg gcctgggcca ggaagtgcag tacgccgtcg
      481 aactcccgtg cgaggaggcc gagtacgccc acctccggct gcatcatgac cggctgctgc
      541 cacgggtccc cggcccggtc cgcgtcgtgc acgcgcaggc cctcgacggt gaagaagcgg
      601 ccgctgcggt ggaccaggtt cccggtgtcc tcctggaacg accagccgtc cagctcggcg
      661 aacgggatgc gccggatccg tgtgccgtgg acgcggcggc gctccgtcag ccacgcgacg
      721 atctcctccg tcgtgctccg ggcgccggtc gccgggccgg tggcggccac ggagcgggcg
      781 atccgggctt ccagtccgtc cggtccggcc tccgtgtcct gcggccggga gctgtcgcac
      841 ctcacctgcg gcccgccacg aactcccgta ccgaggcgat gacgtagtcg gtcatctcgt
      901 cggtgagacc cggatagaca ccggtccaga acgtgcgctc cgtgacgatg tcactgttgg
      961 tcagttcacc gacgacgcgg tggggctgcc ggaggtaggc gggctggcgg gtgaggttgc
     1021 ccgcgaacag ccggcgggtg ccgatcttcc gcttctccag gaatccggtc agctctccgc
     1081 acgtgaacgg ggcgtcgggc cctaccgtca tcacgaatcc gaaccagctc ggatcgctgc
     1141 cggccgtcgc ctccggcagc aggagatgac gtacgccgtc caggccctca cgcatccgcc
     1201 gccagttgtg gcggcgcgcc gcgatgaacc cgtccagctt ccgcagctgt gacaggccga
     1261 gtgccgcctg caggtccgtc gacttcaggt tgtagccgac gtgggagaag atgtacttgt
     1321 ggtcgtatcc ggccggcaac gcgccgagct ggtggtcgaa gcgcttcaga caggtgtcgc
     1381 tgtgacccgg ttcgcaccag cagtcccgcc cccagtcccg cagtgactcg acgatccgcg
     1441 cgactttgag gtccgaggtc gtcacgatgc cgccctcacc catcgtcaga tggtgcgcgg
     1501 gatagaagct cacggtgctg acgtcgccga acgtgccggt cagccgcccc cggtaggtcg
     1561 tgccgaccgc gtcgcagttg tcctcgacga acaccaggtt gtgttccgcc gcgagttggg
     1621 cgatctcctc cacctcgaac gggttgccga gggcgtgcgc gatcatgatg ccgcgggtct
     1681 tcggcccgat ggcggcggct acgcggtcgg cggtggtgtt gtaggtgccg agctcgatgt
     1741 cgacgaagac cggcaccagg ccgttctgca ggatggggtt caccgtggtg gggaaccccg
     1801 cggcgacggt gatgacctcg tcgccgggca gcaggcgccg ttcgcccacg agcggggacg
     1861 tgtaggcggt gagcgccagc aggttcgcgg acgaaccgga gttggtcaga tgggccttgc
     1921 ggcgcttcag caaccgcgcg aagccggact cgaagcgctt ggagagcggc ccggcggcga
     1981 tccgcagatc cagggcggcc tccaccagcg ccgcgcggtc gtcctcgtcc aggacggcgc
     2041 cggacggcca gatctccgtg gtacccggta cgaactcccc ggagccgcgc acactttggt
     2101 ggtgcttcct ggcctcttcc agggcccgtt ccctgtgctc gtgattcacg cccgactctc
     2161 ctcgtccccg gcctggtcct tcgcggcctt ccaccacgcc gtgttctccc ggtaccagtc
     2221 gacggtggcg gccagccctt cgtcgaagcc gacccggggc gtgaacccca gctccgtacg
     2281 ggctttggac ccgtccagcg agtagcgcag gtcgtgtccc ttgcggtcgg tcacatgccg
     2341 gatcatggac cggtccgcgc cgcacagggc gagcaggtgc tcggccaggt ccagattggt
     2401 cagctcgtgg ccgccgccca cgtggtagat gccgcccgcg cttcccttgg tcagcacgag
     2461 ctggacggcc cgcgcgtggt cgtccacgtg gatccagtcc cgcacgttcc gccccgagcc
     2521 gtacagcggg atcggctcgc cctccaggag gttggtggtg aagcgcggaa tggccttctc
     2581 cgggtgctgg taggggccgt aggtgttgga gcagcgcgtg atcgacacgt cgagcccgaa
     2641 ggtgcgccag taggagcgta cggtcaggtc cgccgccgcc ttggaggccg cgtaggggga
     2701 gttgggcaga agcggcgact cctcgtgcca ggagccctcg gcgatgctcc cgtacacctc
     2761 gtccgtggag atgtgcacca cgcgctccac cccggcgttc aggcaggcgt ccaggagggt
     2821 ctgggtgccc accacgttcg tccgggtgaa gacggcgggc gcgtccaggg acctgtcgac
     2881 gtgcgactcg gccgcgaagt gcaccacggc gtcgtgtccg ggcagcagtt cgttcagcag
     2941 gggcgcgtcg cagacgtcgc ccttgacgag gtgcagccgg gggtggccga gcggaatgtt
     3001 ctcggcgttg cccgcgtagc tcagcttgtc cagcacggtg acgtcggccc gctcgtagcc
     3061 cgggtacccc tgcgccagca tcgtccggac gtagtgcgag cccacgaatc cggccccgcc
     3121 ggtgaccagg atcctcatcg ggttcctcct gtacgggcgc cgttcgcggc cagttcctgg
     3181 gggagcggca ccgggggcgg gcccgagccg atccgcatcg cgcggccgat gagcaggtcg
     3241 ctcgcgcccg tccgtcccgt cacccacgcg tcgtccatca cgatggagtt ctccagttcg
     3301 gtgtcgcgca gtacacagcc gctgccgatc gacgtgcccg gtccgatacg gcagtcctcg
     3361 acgagggagc cggggccgat gatcgccggc ccggtgatga ccgagcgcag cacggtggcg
     3421 cccggggcga cgtgcaccgg gccggtcagg cggctggcgg cgtcggccgt tccgtggatg
     3481 ccccgcgcca gggtgcccag caggcgccgg ttgcagtcca gcacgtcctc cacgcgtccg
     3541 gtgtccttcc agtagccggt gtactcgccg gccgtgaccg gggccccccg gtcgaccagc
     3601 cactgggcgg cgtcggtgat ctccagctcg ccgcgtgcgc tgggcgcgat cgcggcgacc
     3661 gcccggtgga tggcggggcg gaagaagtag acgccgatga gtgccaggtc gctgagcggc
     3721 aggcgcggtt tctccaccag ccgtcggacc cggccacggg cgtccagctc ggccaccccg
     3781 aaggcgcggg ggtcggcgac cttggccacc accaggtgcg cgtcggagcg gcgggcccgg
     3841 aactcctcgg ccggccccgc tatgccgtcc tccacgacgt tgtcgccgag gtacatcacg
     3901 aagtcgtcgt cgccgaggaa cgggcgggcg agggccacgc agtgcgccag gcccagcggc
     3961 cggagctgcg tgaggtaggt gatccgggcg ccgaaccgcg atccgtcgcc gatccgtgcc
     4021 gcgatgtcgg gtccccacgc gccgacgacc acgcagatct cccgcacgtc cagcgcgcgg
     4081 aggttctcca gaacgtgttc gagcacgggc tggttggcga cgggtatcag ctgcttgggc
     4141 atggtctcgg tgaacggccg cagccgcgtc ccgagtcccc cggcgagtac gagcgccttc
     4201 atgggcgttc ctcccgtgga gcggtgcggg ccggggcgcg cggcgcccgg caggacgcgt
     4261 gcgcgtacgc acctggtacg gctgtctcgt cgatgcccac aggcgggcgc ctccctcggt
     4321 gattcccgtc ggcgtgcgtc aggccccggc cagggccagg tggtgagtga cggcttcgcg
     4381 cagggcgttc gccaccgtcc gggtctccgc gtcgctcagc gcctggtgga gggggagcag
     4441 cagcgtgctg tcggtggccc ggtcggtgcc gggcaggtcg gtggagtggg cgccgtaggc
     4501 gggcacccgg tgcagcggtg ggtacttgaa ggtggtgtag atgtcctggg ccagcagcgt
     4561 cgccgcgacc cggtcacgga tgagcggatc cagctggacc cagtagaagt agtaggagga
     4621 gcggtgcccc tcgggcagcg ggggcggcag ccgtacgcca ggggtgtccg cgagcaggct
     4681 gtcgtaggcc gtcgccacct cgcgccgccg ggcgacgttg gcgggcagcc ggccgagctg
     4741 caccgtgccg atcgcggcgg tcaggtcgtt gcctatgaca cggcggccga agctccgtac
     4801 gtcgagctcc caccaccgct cggacacctt cgcgtggccg aagccgctgg gctgctccag
     4861 accgtggtag gcgaggaccc gggcgcggcg cgcgagctgc ggatcgcgga cgtacagcat
     4921 gccgccgtca ccggtcacca gcaccttcat cgcgtcgaaa ctccacaggg cgatgtcgcc
     4981 gaaggtgccg cacgccttgc cgccggccgt ggaggccacg gcgcaggccg cgtcctcgac
     5041 gagcgggacc ccccgccgcc ggcacagggc cgcgatctcc gcgacctcac cggggtagcc
     5101 gccgtagtgc agcacgatga ccgccttggt gcgcggtgtc atggcgctct cgacgtgctc
     5161 cgcggtcggg tggagaccgt gggggtcgac gtcgcagaag acggggcgcg ccccggtcac
     5221 ggcgatggcg ttggcagcgg ccacgaagct cacggacggc aggaccacct cgtcgccggg
     5281 gcccaggtcg agcagctcgg tggcgaggaa gagcccggcc gtaccggagt tgaggaagag
     5341 cgtccggtcc ggttcgaccc cgaggtggtc cgcgaagcgt gcttcgaact cggcggtgcg
     5401 gggtccgtgg cccagccagt tcgaggcgaa cacctcggac agggcgagga gttccgcctc
     5461 gcccaggctc ggctggaaga cgttgatcac gcggtggctc cctggcgcgg tggggacgat
     5521 gggaaggtgg cgggttcagt cccggctctg gtggtgccgg gtgaggcgct ccaggacggg
     5581 gacgatctcg cccggctccg gagcggtcag caggtccgtg tacagctccg ccgcggcgtc
     5641 gcggaaggac ggcgcggtca tcagccggga cagccccgca cgcagttcgg cgccggtgtg
     5701 acggtcgacg cgcacccccg ttcccacgcc gctctcggag aggaaccggc ccgtgagcgg
     5761 ggcctccatg gggtagccgg ggtccatcac gacgaactgc ggtatccggt tgaccagggc
     5821 ggcgccgaac gttccgtggc cgccgtggtg gatcaccgcc gaacaggtcg gcagcagttc
     5881 ggtcagcggg acgtagtcga cggtccggac gttgtcgggt atccggtcgg ccacggcgag
     5941 ctgggaggcg tccagggtgg cgacggcctc gacgtccagg ccgtccacca tctccagtac
     6001 gcggttgacg agcagggcac tgtcccgtcc ccaggcccgt atcgaggaac cgagggtgat
     6061 ggccacccgc ggtcgtgcgg gcggttcccg cagccagtcg ggcagcacgg ccgggccggc
     6121 gtagggctgc cagcgcaccg acacggtgcg cttcctggtg ggcaggcgca tccgctccag
     6181 caccgggttg accgtccact gtccgaacag cagctcgtcg gtcaggggga gcccgtagcg
     6241 ctcggccatc ggtctgaccg acgaggtcat cggctcctcg ggcaggaggg cgtcaccgga
     6301 gagcttcgcg caccgggtgt actgctcgtg cgcccagccg aacaggtccg ggccccacag
     6361 gatgcgggcg tgggcagcgc cggacacctg ggcggccacc ccggcggccg gcatcgtggg
     6421 gtcccacagg accaggtcgg gccgccacga acggcagagg ccgaccagcg cgtcgagggc
     6481 gtactggggc gcgtcggcgg gagcgcgctc cggctggaag tcgcggatgg cgggcagcat
     6541 gtagtcccgg aagtaggtcc acacgtaccg cccgtagctg tccaggtcga gggacttggt
     6601 gaggctgacg aggtcggcgt acgtgtccgg ggcgatgggg cggccggcgc ccagcggctg
     6661 cggcagggtc tcctcgtcgc tgagcgacac gcccgtaagg ccggtcgcgt tgatcgtgtc
     6721 cagcagcgac ggatgggaga cgacccgcac ctcgtggccc gcgtcgccca gggcccgggc
     6781 catcggcaca ctggggtaga ggtgggccgc ggcgggccag gtgcagaaca ggacgcgcat
     6841 ggtcgtcttc tctccgaccc gctcagaggc gggtcatggc ggcgaaccag gcctgggcgg
     6901 tcccggggtt gaaggcgacg tcgagttcgg ccgcttcgag tgtgtccacg cgccacccgg
     6961 cgtcggtgaa actctcccgg acggcctgct cgggaacgcg tcgcggaccc caggtgcccg
     7021 gctgccggtc gctgaagcac atcaggaagc agcgtccgcc gggcggtacg acggaggcca
     7081 tgctgcgggc gacgaggggc cggtcctcgg gggcgaagca gtggaagagt ccgacgtcga
     7141 tgagcgtgtc gaactgctcg ccgagcgatg cgaggtccag ggcgtcccac tccaggaaac
     7201 gcgccttcag gccgcgttcc cgcgccttgc gggcggcgag ggtgatcgcg ctgggggcgg
     7261 cgtccacgcc cgtcgtctcc aggccgtgtt cggcggccag cagggcgttg tcgccgctgc
     7321 cgcagccgac gtcgagcacc cggccgcgga gcgcgccctc ctcggcgagg cgtacgagga
     7381 ccgtctgcgg ccggttgatc tcccagccgg cgcccggcgc gccggcgtag tgacgctcga
     7441 agacctccac gccgctgtcg gccggctgct cacgcgcgcc gaccccggcg atctggtccg
     7501 acggctcgct catggtctcc ccccggaatg tgcggtcggt ccgccgccgg ccccgggagg
     7561 ggccgtcggc attctccgcg agaaactagc ccacgcccgg ggcccgcggg atcgaagtga
     7621 ggggggcggt gacacatatc aggaacctgc ctcggcgcct tgctgtcgcg gcgcggatct
     7681 gtcagggctc ccggacccgt caccgggtgc ccggtggccg gcccgggcgg ggacggtcgc
     7741 ccgccgcgcg cgggccccga cggccggtac agctcgtcgc caccggtccc gggacggcct
     7801 cccgctacgc gcggaccccg atgaacagcc cccggccgtt cggccagtcg gggaggaact
     7861 ccaccgcgca ccccgcctgc tcgaaggcgt ccaggtattc ctcctgggtg aacagcgagt
     7921 acgtctcgta ctcggtgaac tcacggatgc cggaggtctc ggcgacggtg tagcgcaccg
     7981 tcatccggct gatgcgtccg tcccggacgg agtgcgacag ccggctgacg gcccggccct
     8041 cctcctgggc gagggaggcc gagatgaacc cgtcgatgaa ccgctccgga aaccaccagg
     8101 gctcggcgac gagcacgccg ccgggcgcca gatgacgcac cagggtcgcc gcgctccggc
     8161 gcagttcccc gacggtgctc atgtatccca gggagaaaca catgcagagc accgcgtcaa
     8221 aggtccggcc gaggtcgaac tgccgcatgt ccccctcgtg cacacgggcc gcggggactc
     8281 tccgcgtggc tgtctcccgc atgtcggggg agagttcgac gccggccacg gtgccgaagt
     8341 gtccggcgaa ccgctccagg tgcgcaccgg tgccgcacgc gacatcgagc agcgaacccg
     8401 cttcgggaca acgctcccgg atcatccggg cgatgccgtc cgcctcggcc gaccagtccc
     8461 ggccccgggc cgcgtggacg aaatcgtaga tctcggcgtg ttccgtgctg tacaccgtcg
     8521 aagggatctg cggcgtatcc atcgtgatgc tccgtccatg tcgtcgggac ctcggcgagc
     8581 tgtctgcggg agccaaggtt ctatcatccc ggcggcccgg cccggagggc gccgatgccg
     8641 cccggtacgg ccacatctgc gggccttcgg ccgtccaccg tccggggacc gcgccacggt
     8701 ggacggttcg gcggcacatg acagatgtca ggttccgtcc actgctcgtt gtccggggcc
     8761 ctgcgcggcg gcattgtgag ccctgccggg ccgcgtcaca ccacgtcggg cggccgccat
     8821 ctcccgaaac gccttccgat catgaacggg tacgcagcgt gatcacagac acagcagccg
     8881 ccggtccgga gatgtccgag gcggcggggg tacggctgta ctcccgggtg cccatcaccc
     8941 ctcgctggct ggcgcggaac gtgctgccgg tcagccggcg cctccgcgag gaccgccagg
     9001 ccgccctcct ccacctgcga cggggctggc tgtacggtcc acacgtcgac atcgtcgccc
     9061 ggagcgtgcc cgggcggccg gcgctcgact gggcggggat cgccaccggc ctcgacgccg
     9121 gccccgccga aggcccgaac gtgatggacg aggagaccta tctcgcccag gcccgtgaga
     9181 cggggcggct ggaaggcgtc gcaccgccct acctgccgat gcgtgagcac ggtgtcacgg
     9241 aggcgctgag cttcgcctcg gtcgagacct ggccgcagcc gctccaggac ctccgggaga
     9301 tggccctgga ccagctggac ctgccgctga ccatgacggt cgagcggctg gccgaggagc
     9361 cgcgcgaggc gccggtacgc ctcatggagg cgttcatcgc gctggccgcg gcgcaccagt
     9421 acggagccgg gaacggggcg ttctcgatgc gctcgcacgc cgaggcgttc ttcgcctggg
     9481 cggccacccg caaggacccc cgccccgcct tcgcccagcg gctggccgcc gacgcccccc
     9541 gcctgcggcc cgtcgtggag cgggcgctct ccggtacgcc cgaccacggg acggcggcct
     9601 gggcccgtgc cttcgcctac tccatggggg ccttcgacgc cacggtcgcg cagggaaagc
     9661 tgaccctgga cgacatcgac ggtctcggcg gcggtttcga cctggacacc atgggcccgc
     9721 ccggcgggga cggccgcgtg agccacgaac ccagcgcctt ccaccgcacg atggacgagt
     9781 ccggcgtcat cgcctcgccg ccgaagtggt tcgcctccta ccggctgctc gtcaacctct
     9841 tctaccagca gctgccgctg ctgggcgtgc cgcccatgca ccgctactac ttctgcttcg
     9901 ccgtcgccga actggtggac gacgtcctcg gttcctcctg ggaggacagg ctggagcaga
     9961 cacgacagga gatggcgcag gccaccgccg gggcggcgga atgagcgaca ccgcggagcc
    10021 cctgtggatg ctgcgcctca acccgctgcg ccggagaagg ctcgcggacc ccgggctcct
    10081 ggcggcgctc cgcacgctgg acggggccac gaccgaggtg cgcgagctgg ccggccagtg
    10141 ctccgacgtg ctctacgaac tgatcggcgc cgccaccgac cgtcaggcgc gcgggcagct
    10201 catcgtgttg cgccgcgcca tccacaacga cacagccccg cggccggcgc tgctcgtcga
    10261 ccaccccctg gtcggccgct ggtgggaggc ccggcagcgg cgggagacac ttgccgccga
    10321 tgtggtcggc cgctatccgg gggcggtgga cgccgagcgc gggacgctgg ccggactgct
    10381 gggcgacgag agcctgcggc actccatgac cctggtggct cccgacgcgg cagccggtgc
    10441 gggacggtac gtggcggccg tcgccgccgc cgagcccgtg cccacccggc tgcgcaagtc
    10501 cgagcgcggg ctggtccagt acgtcacccg ggccatgatc cgcaccagcc cgatggcacg
    10561 cttcaccgcc atcggccttg ccgtccccga accgcacgga ccgggccccg acgccccgga
    10621 gttcgggcgg gtggtgccct tccaggggct ggaccgcgtc atgctcgact acgtactggg
    10681 cgggctgcac acctcggacg gcgagatcac ccccgacacc ctgctccaac tgccgcccac
    10741 ctccgacctg tcggccgaag gcgacctgct gtacttcctg cggcccggag ccgacggcgg
    10801 ggtgcgccgc ctgtcggcca aggtcacggg cgcggtcggg ctgttggtgg ccgccgtcgc
    10861 cgtcggccca cgccgcgcgg ccgacgtcgc cgcgggcttc gccgcacgtt ccggctgtac
    10921 ccccgaactc gcctggcagg ccctggcgcg tgcggtgggc gccggcatcc tgtgcacccg
    10981 cagccgcccg gaggacggcg cggccgactt cccggatctg ctcgatcccg ccggtcactc
    11041 cgtccccgag acggcccgga ggcttctgga gcggaccggt gccgaactgc gcgggctcgc
    11101 ggacaactcc gccgacgagc ggcccgaggc gatgagccgg ctgcgcgcca cactggccga
    11161 gctgagccgc gaggcgggac ggcccgcgca gatcctcatc gaggaggacg ccgtgctgga
    11221 ggacgtccgg ctgtccaccg ccgactggcg gggccagctc gacgacctcg ccgccggagt
    11281 ggccctgctg tccgtcttcg actggatgca cgacatacgg gcgttgctgt ccgccgtctt
    11341 cgtcgagcgg ttcggcgtcg gcgccgaggt ctcgctcagc gaccacgcgg actacctgag
    11401 caccgagacc taccggcggg cctaccgcct ccccgagaag gcgccccccg gcgaactggg
    11461 cccggccgac cgctcgctgg accggctgta cacgctgcgg gcgaacgtcg tcgacaccgc
    11521 gatcgccgcc gtcgaccggg cggtggccac cggcgaggcc gtcagctgga gcgcctccca
    11581 ggcactcgac ctgacgacgg gcctgcccga ccgcttccgg accggcgacc tccgctacgg
    11641 cgtgctgacc cagacctggc agcggcgact gctgttcaac gaggcctacg cgggccacgg
    11701 catgctctac ggcaggttcc tcggaccgga ccgcgccctc ggcgggcgcg ccctgcccca
    11761 cttccgcgag cagctccgcg cccgctacgc cgagcacgac gggcggctgg ccgaggacct
    11821 ggggctgcac cggctcaacg tcaacgcgca cccgccggtg ctcccggacc ggctggggcc
    11881 ggacgactgg ttccgcctgc gcctgcgcca cgacccggac acggacacgc tcggcatccg
    11941 ggaccccgac gaccgcccgc tgcacgtgct ctcgctcggc accgggcacc cggagaggct
    12001 cccggcgccg ctccggctgg ccaactggct gtactccggc ggcgtgctgc gcgaaccctt
    12061 catggcgatc cgccacggcg agcagcagtg ggacggcgtc ggcaccctgg cctgcccgcg
    12121 cttccaggtc ggctcggccg tgctggcgcg acgccgctgg tacgggggcc gggaactgga
    12181 cgaggcggtg gccgcggggc ccgccgagca cgaccggctg ctggcgctcg cccggtggcg
    12241 gaaccggcac ggcgtgcccg aggaggtcgt cctgaagccg ccgcccgatg acggcaccgg
    12301 cgagggccgg accaccggcg agggccggag cgccggcgag ggcagaaaga agaagcccca
    12361 gtacgtcgac ctggccagcg ccctcagcgt gcgggtgctg ccccgaatgg tggagcgggg
    12421 cgaggcggcc tacgtggagg aggcgcttcc ccgggtggcg gacagcccgc acgccctgga
    12481 gtggatcgtc gacatcggcc gcgctcccgg cggccccttc cagtacggag gaaagacccg
    12541 atgacgctac gcgcgcgtcc ccatctgcac tatgcgccgg tctcggaagg gctctacatc
    12601 aacggccccc gcacccagtt cgtgatcagc ggcccccagc tgctctaccg ggtcgccgac
    12661 acctgtgtgc cgctcctgga agcgggaacc accgaggacg aactggtcac cgccctgggc
    12721 agcgaacggg ctcggcccgt cgtccgccgg atcgtcgagg agctgcgggc ccgcgggctc
    12781 ctgctcgacc tggacgcgct gaccgtgccc gagccctcgg ccgagatccg cgcccgctac
    12841 ccggaggccc tggcacacct ggagacggag tgcgccgacc cgtacgccgt cttccagcgg
    12901 ctgcgcacca ccgaggtgct gctgtgcggt ccggccgatg ccgtgctgcc ggccgcccgc
    12961 ggactgcacc gggccggggt caccggcctc acgctggcca ccccggaccc cgacgcggcc
    13021 gccgccaccg cctcccggct gggcatgcgg ctgctgccgc tcggcggcac cgcgacgctc
    13081 ccggacccgg cggagctgcc cgtgccgccg gacgccgccc tctactgccc cggcgcggac
    13141 gacggcgaga ccccgcgagc gctggccgcg ctgctgccgg cgggggcgcc cgtggtcccg
    13201 gtgcgctggg acgggctcgt cgcggccgtc ggtcccgtgt ccccgggcgg agcctcgctc
    13261 cccggctcgg ccgcgctcgt ccgccgggcc gcacactggg ccgtggccga agcgaccgcc
    13321 cccgcccctc accccacggc cgcggcactg gccggggcgc tcgcggggca gttgctgttc
    13381 gacaccctcg cgggcatcgc gccgcccggc gaagcacatg tcctgcacgg tgaggaactg
    13441 acggcggacc gggtgagcgt gagcctcacg gcccccggcc ccaccgccgg cgaggccgcc
    13501 gagcggagct tcctgacagc cgcgcccgcg gccggcgccg aacccgtagt gccgcccacc
    13561 cccgacgagg ccgtcgaggc ggtgaccgcg ctcaccgggc gctggaccgg acccgtcgcg
    13621 ctgctggccg gcgaggaact gccccagatg cccctggccc tgcgggagat ggccgcccgc
    13681 gacggcggca ccgactccgt ggtcgcctgg gccgaggagc agcggacggc gacggtcgcg
    13741 gtcgccctcg ccgctctccg ggcggcctgc ccgtccccgg gcgcagccgc cgcggggctc
    13801 accgaggagc actggctgct ggacggcgcg ctgcggctga tggccgacga agccgtgccg
    13861 tacgcgacga ggaccgtggg ggccgtggag gcacactcgg tgccgctgct gcgcatgctg
    13921 gaggaagagg gcatgccgga cccggcggtg accctgctgc gccaccccgg cctggactgg
    13981 accctggcgg aggtacgggt ctccggcggc ccgcggccgt ggaccggagt gagctggggc
    14041 cgtgacgaca cggaggcggt gcaccgtgcg ctggccaccg cgctggcccg gcaccagacc
    14101 cacggggtgc ccggcgcggg ccccctggcc gacggcgtgc acaccgacgc cctgctgttc
    14161 gccgacgccg cggagcaggc cgcgctgcgc aagcgggtcg cggactcggc cgccgccgcc
    14221 gggctccgct acgagggcac cccgcggcga ccggacccgg tgacgggggc gctgcccctg
    14281 tggtcgggca ctgtccgggc cgtcccgctg gccggggagc cgcaggttac ggaagcgagc
    14341 accgaggagc cggaccgtgg ctgagaaccc gaccaccgtc gtctgcgcac ccgcactgtc
    14401 cgacgccacg gacaccgact ggcgtgttgt gctggagccg ctgggcgcct ttggggacgg
    14461 caccgtcggc gtcaacctcg gctgggacct ggcctgggaa cgtgaccggc tgcggtcggc
    14521 cggcgagcgc gagcatctgt ccgtccgcgt ctacggcgac gaggtgctgg tcggcccccg
    14581 ctgggtgccg gggacggact ccggctgcgc gggctgcgcc gagctgcgct cccggctggt
    14641 gatcgaccac cccctgaccg acgacctgac ccggcccacg gcgcgggtcg ccccgcgccg
    14701 cccgttcctt gccgagctca cccgcgcggc gctggcacgg ctggccgacc gccccctggg
    14761 gccgggcgag ttgtacgcgg tggggtcgcg ggggacgcgg acgcaccgcg taccccgcca
    14821 cttcgcctgc ccgctgtgcg cgccggagat ccccgaacgg ccggtgggcc ggccgccgga
    14881 gcccctggcg ctgcgaccac gccccgccgc cgcggacaat cccggccggg ccgcggccgg
    14941 ggccgcgctg gtgcggcccg gagcgctgcg ctcacggctg gtggacccgc gcttcggacc
    15001 ggtcctcgcg cagcaacggg agctgctggc cccctttgcc atgagcatgg cgctccagcc
    15061 cgacgcggtg gccctcggct atgcccgcga gacgaccttc gccaaggcgg acccgatcgc
    15121 catcctggag gtgtacgagc ggctttcggg cttcccgcac caggcgccgc tcgtcgaggg
    15181 ggtctcgtac gccgatctcg tcgccgccga gggcggagcg gaggtcgcgg tgcggcccgc
    15241 cgcgttcggc gagtacaccg aggagcaggc ggcacgtccc accgcgcgga tcgagcgggt
    15301 gacggacgag acgccgatgg actgggcgtg ggggcacgac ctggcggacg gccggccccg
    15361 gctcgtcccc gccgaactcg ccttcttcca gtacgactac cgctacggac gggagcagcg
    15421 ggcggcgcgc cggcacgggg ccgcgccgcg ccggcacctg taccaggagt cctccagcgg
    15481 ctgcgcggtc ggctcctgcc tggaagaggc agcgctctac tccctgctgg aactcgccga
    15541 gcgggacgcc ttcctgatca gcttccaccg agcccgcccg ctgccggaga tcacccactc
    15601 ctcgatcacc gacccggtcg cccgggggct gctggcgacc gccgcctcgc gcggcttccg
    15661 ggtccacctg ctccgcgcca cccaggacat cgacctgccg gtggtctggg cgatggcggt
    15721 caacacccgc gctccgttcc cggccacgtt ctccgccgcg ggctccggca tcgacccggt
    15781 ctccgcgctc cgcggggcgc tgtgggaggt gacccagatg gcgaccgatc gcctgacctg
    15841 ggaccgctcc gaggccgaac cgatgctggc cgacccctgg ctggtcgacg agatggacga
    15901 ccacctgcgg ctctacgcgc tgcccgagat gaaggagcgg gtcacgtccg tgctgggcgg
    15961 gccggagatg agcctgtcgg aggcgttcga gggctggccg gaccggctgg aacaggccgc
    16021 cgggggcgat gtgctcgggg cgctggacta catccggggg aggtacgccg cggccggact
    16081 ggaccggatc gtcctggtgg actccaccac acgggaccac gccgacatcg gcctggccgc
    16141 cgccaaggcc gtggtgccgg gcatcgtccc catgtgcttc ggccaggccc agcagcgagt
    16201 ggccgggctg ccgaggctgg aggcggccct ggccggaacg ccctccggcg atctgtcgcc
    16261 gccctacgag ccgcacgcct tcccctgacc cccggccgtc ccacaggccc agcaggcgcg
    16321 gcggacgcgc gccgttgttc accgaaccac cgaggcagac ggagttcccc atgacagata
    16381 ccagcgaccg gggcggccct gcgtcaccga tcccggacga tgccgatgtc atgtcgcgcg
    16441 acatgcggtg gttcacctac gcgacggggc tcggtgtccg ggtggagccg gcggccgtcc
    16501 ccgagccacg cccggacacc gaggtcgcgc ccgcgctccc ggaggcggcg ctcggcgacc
    16561 ggacgcccct gccccggggc acggcggagc tgctggagcg ggcgccctat ccgcacggcc
    16621 gggccggcgc cccgcgcgag agggccgacg ccctcgggca cgccctggtc gcgggcttcg
    16681 gcctgcaacg gcgggagccg gagaacccgt tcaacgacca ccgcccctac ccctcggtgc
    16741 gggcgaagtt tcccgtccag gtgttcgtcc gggacggccg ccaccgccgg gtgctcgacc
    16801 tctaccggca cgcgctgacc ggtgtgggac gccaggacgg ggcggccggt ccgctggagg
    16861 tggcgctggc cgggaggtac acccggctgc ccgactccta ccggtggttc cgcagctccc
    16921 tgatcggcct cgaactgggc gtcaacctcc gccagttgtg tctgggcttg gacctgttcg
    16981 gcctgtccgg aaagctgcgg ctgccggacc gggacgcggc gggtctgctg acggacttcg
    17041 gcctgacgcc cgagtcggag tggtccctgc cgctgaccgt ggccctggag gacggcgggc
    17101 cgcccgccgc cgcgcccccc gcggagcggg ccgccgaccc cgtcctcgac gggatcctga
    17161 ccgtcaaccg ctcccaggac ttcacgggcc cctccgcccc gctcggcccg tccgtcccgg
    17221 ccggactgcc ccgggacggg acgctgtcct gggcggaggt gctgtggcgc cgcagcgcgg
    17281 gacggatgcc gcgcggcatg tacggcatga ccggccgcag gcggccggtg cccgagcgga
    17341 cgctgcgcga ggccgtcagc tggctgaacg tcccgccccc cggcccgcac ctggccgccg
    17401 cctgggagga actgcgcctg accgccgtgt tccagggcat cgaggggcat gccgacgggg
    17461 tctggcacct gcgagacggc cggccggtgc tgcaccgggc ccagcccggc gccgcgtccg
    17521 tactggagga gcactacggc taccccgtca ccccgtacgc cgggggcgac gtccggcacg
    17581 cgagcgtggt gtggttcctc tccgcgagcc cacgaaggct cgtggaacgg ctgggccccg
    17641 gcggattcac cgccgcccag tacgcggcgg gctgggcggc ccagggcatt tcgctggccg
    17701 ccgccgccac cggtctgtac gcgaggcccg cgcgggcctt ccaggaagtt ccgacgaagc
    17761 aactcctcgg cctggacgcc gaggagatga tcgtctgtgc cgccatcacc gggaccccgc
    17821 gcttcgaggg gctgttgtgc gacctacgcc tgtgacgaga gggcagaagt tgacggacac
    17881 atccgagacc gcgcgcgccg gggacggcga caccggctcc ggcaccgtgt ggcggacctg
    17941 gcatctgcac gtgtcgagcg gcgaccgcag cgtgcacgac cgggtgctgg tcgaggcggt
    18001 cgtgccgctg atccacaccc tgccggaccg gccgtggttc ttcctccgct actggcacgg
    18061 cggcccccat gtccgcctgc gcgtagggga tctgacggac gagcaggccg cgtcggccga
    18121 gcggctcctc gccgagcgcc tcgcggacgc cgggcggctg cgggagggcg agacggcgat
    18181 gagcccggcg gactacgcgc ggaccgcctc ctccatgacc acggccgggg accagccctc
    18241 ccaccaggag gtcaccggca tgctggagcc cggtgtccac cgcttcgcct accacccgga
    18301 gtacgagcgg tacggcggcc gggaactcct gccggagagc gagcggctct tcgagctctc
    18361 cagcaggctg gttctctcct ttctccggcg ggggccctcc gccggggccc gggctctgct
    18421 ggccctgcgc gccaccgtct gcgccgggcg ggcgctcggc gacgaccccg ccgaggaggc
    18481 ggccttctac gatcacggac tgcgcgcctg gcgtacgtgg gcagccggct acggctacac
    18541 ggagcggcag ctcgacgagc tgtaccgggc cgcccggccg accgacgagc tgcgggccaa
    18601 agtggcgggg ggagacaccg cgggcccgct ggcaccgtgg caggcggcgc tcaccggact
    18661 gtcggaccgg atacggcggg agaccccgct ccacccggca caggtcaccg tctcccacgt
    18721 ccacatgctg cacaaccgcc tcggcctgcg ggcggtcgag gaataccaga cctatgcccg
    18781 gctggcgagg ctcttccccg tccggtcggc ccccgaaggg gcgccccctt ccgaccactc
    18841 cggaccggcg cagagcggcg cggtcctgac acccgaggag caccgatgag caccagcccc
    18901 accaccgcca ccgcccgcgc aggggctccc cccacaccgg ccgtcatcgc ccgcgccatc
    18961 ggcgtcaccc ggcactacgg ggacaccgtc gccctggaca acgtggactt caccgtgcgg
    19021 gagggcgagt tcatcggcct gctcgggccg aacggcgccg gcaagaccac gctgctcaac
    19081 tccctgctgg ggctgcgcaa gccgacctcc gggcgcatcg agctgttcgg aggctccccc
    19141 acgaacccgg ccagccggcg gttcatcggc gtcaccccgc aggagagcgg cgtaccgccg
    19201 accctgcggg tggccgaagc ggtcgacttc gtggccgcgc acttcaagga gaccgaggac
    19261 cgggacgagc tgctggagcg gttcgacctg accaaggagg cccgccgcca gaccggcgga
    19321 ctctccggcg gccagaagcg ccgtctggcg ctcgccctgg cgttcgtcgg gcgcccgcgc
    19381 ctggtcatcc tcgacgagcc gaccaccggc ctggacgtgg agtcccggcg gatgctgtgg
    19441 gaccgcatcc gcgagttcca cgagggcggt ggcaccgtcc tgctcaccac gcactacctg
    19501 gaggagatcg aggccctggc caagcgggtg gtggtgatcg cccagggccg catccgggcg
    19561 gacgacagtg tgggcgccat ccgggggatg gcccatatgc agcgggtgtc catgaacgcc
    19621 ggaccgctgc cggacctgcc gggcgtcatc agcgaggagc ggacggagga gcgggtcgag
    19681 ctgatgaccc acgacgccga tcagctggtc cgggcactgg tgcgccaggg cgtggagttc
    19741 tccggcctcg ccgtccagca ggccacgctc gaagaagcct tcctggtgat ctcccagtcc
    19801 tgaccccccg cacctcccac gaaagtgctt gaggccatgt catcactgac ccttgtccat
    19861 gcccgctacc agctggtcga gctcagccgc atccccatgg cgatcatcgg cgcggccttc
    19921 ttcccggccg cctcgctgat cttcttcgtg gtgcccaaca ccaaggacga ccctgtcggg
    19981 gccaccctcg ccacggcctc gatggtggtc ttcgcggcga tgatcagcaa tctcttcggc
    20041 cacggcaccg gtgtggccga agaccgctcc cagccctggg acccctacac ccgcaccctg
    20101 ccgatcggcc cggcggtgcg gttcggcagc cgcatcatca ccggtctcgc gatgatgctg
    20161 ttctcgatgg tcccggtcgt gatcgtggcg gcgttcttca cccccgccac cctttcgccg
    20221 gcccgcttcc tgctggcgat cggcgtggtg atcctcgtct ccgtgccgtt caccatgatg
    20281 gggctggcga tcggctacct gctctccacc aaggcggcga tcgccaccgt ccagctcgtc
    20341 ttcctgcccc tggccttcgc gggagggctg ctggcaggcc cgggcgaggc gcccggattc
    20401 atcgaggcga tcgccccgtt cgtcccgacg cggggctccg ccgagctgat gtgggcgacc
    20461 gtcggcgact acgacatcaa cccggtcgcc atcgtgtcgc tcgtggtctg gaccgccggt
    20521 ctggccgccc tcgcgttcta cgcctaccag cgtgacgagg gacgccgcta ccactgagcc
    20581 ccgacggacc gcccgggcgc ccccggcggc tgcgcccggc taccgggtgg cccggcgcag
    20641 ccgccgcccg aactccatga gcagcgccgc gagcccgtcc gcgtcggggg ccgcgccgaa
    20701 caggtagcgg tcggggcgga tcaggaccgc cccggccggc agcgattcca gccagggcag
    20761 ccagtggccg tcggcgtcca gcaccgtgtc cggcccgggt gtcggaccgc cgtcggcgcg
    20821 cacgacggtc accacccggc cgcgtaccag ccgcagcgtc tccagcgcgg cgggggacag
    20881 ggtgtccgcg aggttctcgc ggcacagcag tacgaagccg gggccgagca cggagtcggc
    20941 cgggcccgga ccttcggggc cggtcagccg ggcccggccg gtgagttcac cggccggagg
    21001 cccgccgtcg gcgaggaagc ccttggccag gggctcgccc agcgggctcg cggagcgcgt
    21061 cgagccggcg gggcgcgccg gttcggacgg ccgggacggg ccgggggagg gggcggtcat
    21121 cgcccggtcc ctgtcggccg ccgcggccgg gtcggtcacg cagatcagcc gcccgagccg
    21181 cacggagagg tcgatcgcct gctggacgtg ggcgcggcgc tcctgctcgt agctgtcgag
    21241 gagggcctcc ccggcccggc cgcccagcac caggtcgagc ttccaggcga ggttcgcggc
    21301 atcccggaag ccggagcaca tgccctggcc ggcgaacggc ggcatctgat gggccgcgtc
    21361 cccggccagc agcacccgcc cgcgtcgcca ctgctcggcg ttgcgggccc ggaaggtgta
    21421 ggtggcgtgg cgggtcagtg tggcgttgtc cggcccggcg gagaacatcg acagcagccg
    21481 ccaggcgttc tcctcggtgc cgaactccgc ccggtcctcc ccgggcatcc gcatgaactc
    21541 ccagcggcgg cggcccggtc cgcaggagac ggccacccgt ggccgggcgg gatcggcgat
    21601 ctggaggttg gacggcggga agtcctccgg gcggtccggc accacatcgc aggccagcca
    21661 gtccagggcg aagccggagt cggcccagcc gacgcccagg gagcgccgca cgaagctgcc
    21721 cgcaccgtcg cagcccacca cccaggaggc ggtgaacgtc cgccgctcgc cgccgcgttc
    21781 gtcctcggcg accagctcgg cgccggagcc ggattcggtc agccccacgg cacgcaggcc
    21841 gcggagcacg cgcagcgtgg gcagttcctc gccgcgggcc gcgagcgcgg cctcaagccc
    21901 cggctggtac acggaggtgg agtccggccg gcccgtcccg tccgagccgc ccagcccgat
    21961 ccgcaggagc tgccgtccgg cggcgtcgct gaccacgtag tcctgcgagg gctcggtgat
    22021 gtccccgatc cggccggtga cgccgatggc gtcgagcgta cgggcggcct cggcgtcgaa
    22081 cgccaccgct cgcggcagac tgtacggttc cggatggcgc tcgacgacga cgacccgcca
    22141 cccgctctgg gccagcagga tggccagaac ctgccccacc ggcccgtagc cgacgaccag
    22201 gacatcggcc tccggcgcgc cggcgctccg atcgcgtgac ccagatatcc cgttcatgct
    22261 tctcctgtcc tgaatacccg gtgtccgggt cgtacgggtc cagtcgtgat aatcgaggct
    22321 caccgtaccg attcatcaaa gcgacatttg cgccccttcg agcggctacc aggcggaggc
    22381 tgatgacaaa tgtcagcggc gcttcgcgag agattgccag cgccggaagt gaccgaaatt
    22441 atccatggtg ccacttctac cgaatggcag tcttaatcaa gaagggaaaa cacgtcaatg
    22501 agcatggcca ttgaggcgat gaacgcggac gccctgttcg actccttcga catcgaggag
    22561 ctggacacca tggaggtcgc cgacggcgtc gccctgcccg agatgggcgc ctcgacgggc
    22621 aacaccatgt gctgctcctc gtcgtcctcc tcctgctgct gacgtagcgg caccagctgt
    22681 cagcgcgaca ggtcaccctg cgcgctgaca gtgccacgga ggagaaacgc atactcggca
    22741 ggcggttacc cggcaggaat tgatgacata tatcagctcc aggtcaaggg taattgcgtg
    22801 ccgcgaaccg gttggaaatc gtgcaccgcc ggtctcgcgg ccggcggcca gagcttggag
    22861 gtacaccaag atgagcaaga tcgtggagac catggacgtg gacgcgatgt tcgactcctt
    22921 cgacatcgag gagctgggca ccatggagct cgcggacggc gtcgccctgc ccgagatggg
    22981 cgcctcgaag ggcgactgga cctgctgctc ctcgtcctct tcctcctgct gctgaggcag
    23041 gtgctccagc tgtctgcgcg acgggtctcc cgacgcgcag acagcgccac cgacgagctg
    23101 tgagcatcgg cggaggccgt cggtctccgg cggggaacgc tgacaaatgt cagcgcccgg
    23161 tcacgggtca ttgcgtgccg ggtaccggtt ggaaatcgta ggcaccgccg gtctcgtgag
    23221 ctgttccgct cgttctcagc ctgccgccgg tccggcggcg ggcagcacca cccgcgcacc
    23281 aggctttcgg cgggcggctg tccggcggga attgctgatc aagttcagtg caggcccgga
    23341 gggcgatcgt gtgccgttgg cggttggaaa tcacacgcac cgccggtctc ccggccggcg
    23401 ggccagagct tgggggtaca ccgagatgag caagatcatg gagaccatgg acgtggacgc
    23461 gatgttcgac tccttcgaca tcgaggagct ggacacgctg gagatcgcgg acggcgtcgc
    23521 gctgccggag atgggcgcct cgtacctgaa cgcccccctc tgctgctcct cctcgtcctc
    23581 ctgctgctga ggcagggaca ccggctgtcc gcgcggcggg tctcctgacg cgcggacagc
    23641 gccaccggcg agtatcgacg ggagacatcg gtttccagca ggaaatgctg acaaatatca
    23701 gcgcccggtc gagagttatc gcgtgccggg tgccggtggg aaatcgtgag caccgccggt
    23761 ctcgcggccg actgtccaac agcttggggg cacatcaaga tgagcaagat cctggggacc
    23821 gtggacgctg acgcggacgc ggacgcgatg ttcgactcgt tcgacatcga ggagctgggc
    23881 acgatggagt tcgcggacgg cgtcgcgctg ccggagatgg ccgcgtcgac cgcgcacgcg
    23941 ccgctctgct gctcgtcctc ctcctcggcc tgctgctgac gcaggagcag acagcaacac
    24001 ctgggcaaca agcatccggc aagcggctgt ccggcgtgca ccgctgacga ggtcagcgcc
    24061 gggcagggga aaacgcgtgc cggggtaccg gttggaaatc acacgcacgc cggcctcccg
    24121 gccggcgggc caagagcttg ggggtacaca caagatgaga tcgaccctgg aaaccatgga
    24181 cgtggacgcg atgttcgact ccttcaacat cgaggagctg gacacgatgg agatcgcgga
    24241 cggcgtcgcg ctgccggaga tggccgcgtc gagcctgccg cacacctgct gctcctcatc
    24301 ctcgtcctcc tgctgctgct gctgatcccg cggcgcagtg ccgcctgcgc ggcgggtaca
    24361 ccgcccaccg cgcaggcggc accaccggct gggctgccca gcggagggcg ggcccggcgc
    24421 ccggccccga acggatggtc gtgaccttcc ccatagatgt gcccgactcc tgggccggac
    24481 atgagcacta cgcgcgccgt gtgctgtggc ggctggcccg tcagccctcc ctgcccaccc
    24541 tgtacttccg gggccggtgg ctggacggcg cgacgctggc cgacgcggta cgcgcgaccg
    24601 tggtgggcct gcggcgggcc gggctgaccc ccggcggcac ggtggcggtg ctcaccgaac
    24661 ccaaccaccc cgcgatgctg atcggccgct acgccgctca cctcctgggg gcgggcgtcg
    24721 tccaggtgcg ctcggccaac ccccgctcgg acgcgttccc gctgcccgcc gccacccagg
    24781 cgcggatcct cgacgggacc ggcacgtccg tactcctcgt cgacgccccc catctggagc
    24841 gcgcccgcgc cctgttgtcg ctgaccgagg gcagcccccg cctgctgggt tacggagtcg
    24901 gcgccgcgga ctgccccgac gcgctgtcct gccgggacga gccactcgga gaacttcccg
    24961 cccacgaccc cggccgccgc gccgtggtgg ccttcaccag cggaagcagc ggtgcgccga
    25021 agaacatcca ccagaccttc ggggtctggg acagcaccgt ccggtccgcg gccggcggcg
    25081 aaccggacga gcggcgggtg ttcctcgccg tgacgcccct cagccacacc atcggcgcca
    25141 tggcggacgc ggtactgacc gccggcggcc aggtcctcct gcaccaggac ttcgacgccc
    25201 cgaaggtgct gcgcgccttc gaggaccacg gcgtcaccga cacctacctg gccgttccgc
    25261 acctctaccg gctcacggaa ctcctggccg acgggccggg ccaggagcag ggcgtcggct
    25321 cgggccccgt cggggacgcc ctggggtcgc tgcgccgcgt cgtctacagc ggcacccccg
    25381 ccgcgccgca ccgggtcgcc gaggccctgc gggtgttcgg cccggtactc gtccagctgt
    25441 acggcaccac cgaggccggg ggcatcagca atctgagccc gttcgaccac ctggaacccg
    25501 agctcctggg cagtgtggga cggccgctgc cctgggtgga ggtggaggtg cgcgagcccg
    25561 gcaccggccg cccggtgccg cgcggggagg ccggggagat ctgggtacgc gcctccacgg
    25621 tcatggccgg ctacccggac gacccggagc tgaccgcccg cgtcctgcgg gacggctggc
    25681 tggacaccgg cgacctcggc cactgggacc gctacggcta tctgcggctg accggccgca
    25741 gcggccaggt catcaagtcc ggtggcctga aggtctatcc cgccgcggtc gagggcgcgc
    25801 tgctgtccca cccggcggta cggcacgcgg ccgtccacgg cgtacgggat ccggaccgga
    25861 ccgagtacgt ccacgcggcc gtcgtgctca gggcgggacg gaccgcctcc gcggaggaac
    25921 tgcgcaccca cgtcggcgag cggctctccc ccctgcacgc ccccgccgag atcacgttct
    25981 gggactcgat gccgctcaac gagcgcggca agcccgacct ggcctgtctg cgctccggta
    26041 acggccggca ggcgtacgac ggtgcaccgc cgaagggaac tccatgacca cacaccagca
    26101 cttcggccga gccgtgcggc tgcgccggct gttccaccac gacccccagc ggctgctgat
    26161 cgtcccgctc gatcactcgc tcagcgacgg cccggtggtg ccgcgcggca gcagcatcga
    26221 ccggctcacc gggcagctcg ccggcgccgg ggtggacgcg atcgtggtgc acaagggcag
    26281 cctccgccac atcgaccact cccggctggc ctcgatgtcc ctgatcctgc acctgaacgc
    26341 cagcaccgcg cacgcgccgg acccggacgc caaacacctg gtcaccgggg tggaggcggc
    26401 gatgcgcctg ggcgcggacg cggtgagcgt gcacatcaac atgggttcgc gggaagaggc
    26461 gcggcagctg gccgacctcg gcgcggtggc cgaccagtgc gaccgctgga accttccgct
    26521 gctggcgatg atgtacccac gcggcccgaa gatcaccgac ccggccgacc ccgaactggt
    26581 cgcccacgcc gtcaccctcg cggccgacct gggcgccgat ctggtcaagg ccccctgcct
    26641 gcgcacccgg gcggagatgc gggacctcac cgcggcctgc ccgatcccgc tgatctgtgc
    26701 gggtggcccg cagcgcgaca cggaggacga ggtgctggcc ttcgcccggg aagccgtggc
    26761 gggcggtgcg gccggagtcg cgatgggcag aaacatcttc cagtctcccg accccggggc
    26821 gatggccgcc agggtggctg gagtggtcca caaccgcccc gggagcacgc tcggtcacat
    26881 cgaggaaggg cacggcagtg agctcagaga aactgtgctg gcttgacatc cgttcggcgg
    26941 gcaaggcccg gcaggccatc gtggaggagg cgctgcacca gcggatcgac ggcatggtcg
    27001 ccgccgaccc ggccgatctg gaggggctgc cgccgaccgt caccaaggtg ctgatgcctc
    27061 cggcgggcaa gctgcccgcg gactacggct ccgcccaggt cgtcatcctc gccggtgacg
    27121 ccgccgcccg ggcacaggcc gccgaggccg ctcccgacgt ggagttcgga cggctggtgg
    27181 agatcaccga cgccgagagc ctggacgccg ccatcgaggc ggcccgcacc gaacgctgga
    27241 gcgtgctgga gttccgggac ccgaccaaga tcccgctgga gatcgtgatc gccgccgccg
    27301 ccgacgccga cggcgccatc atcaccatgg cgaagaacac cgaggaggcc gctgtcatct
    27361 tcggctgcct ccaactcggc tccgacggcg tgctgatgcc cggccggagc gtgggcgacg
    27421 ccaccgcgct caaggcgacc gcggccggcg gcaccggcga actccagctg gtggagctgg
    27481 aggtgacctc cgtgagccac atcggcatgg gggagcgcgc ctgtgtggac acctgctcct
    27541 acctgggcaa ggacgaggga atcctggtcg gctcgcactc caagggcatg atcctgtgcg
    27601 tcagcgagac ccatccgctg ccgtacatgc ccacccgccc cttccgggtc aacgcgggcg
    27661 ccatccactc gtacaccctc gccgacgagg ggcgcacccg ctacctcagt gaactgaggg
    27721 ccgggagcaa ggtgacggcg gtggacacca aggggcggac ccggacggtc gcggtggggc
    27781 gggtcaagat cgagacgcgc ccgctgatct ccatcgacgc ggtggccgcg ggtggccagg
    27841 aggtcaacct gatcctccag gacgactggc acgtccgggt gctggggccg ggggacgccg
    27901 tgctgaacag caccgaactc cgccccgggg accgggtgct gggacatctc ccgaccgccg
    27961 accgccatgt gggctacgcg atcgacgagt tctgccatga gcagtagcac cccggcgccg
    28021 gccatcgcgg tgatcggcgc gggcatcggc ggcctcaccc tggccgccgc actggcgcgg
    28081 ctgggcatcg gctgccgggt gttcgagcgt gccgagcagc ctgccgagac cggcgccggg
    28141 gtgcagttgg gaccgaacgc ggtccggttg cttcgccgtc ttggactctc cgactccctg
    28201 cggcagcacg gcgtccgccc gctctcccgc gatctgctgc gctgggacga cggacggctg
    28261 ctggcccgga ccgagctggg cgaggagtgc gagaaactgt tcggcgcgcc gtacgtcacc
    28321 gtgcaccgcg cggacctgta ccgggcgctg cgtggcctgg ccggggcggc ggtgcggacc
    28381 ggccaccggc tgaccgggct ggcggaggag cccggctccg tcgcgctgcg cttcgccgac
    28441 ggctcggagc accgtgcgga gctggtggtc ggtgccgacg gcatccgctc ggtggtgcgg
    28501 gaccacctcg ccgcggacgc cccggtcttc tccggccggc ggatctaccg aggactggta
    28561 ccggtggagc gggtgccgga actggccgcc gagccccgcg tccaggtatg gctgggacct
    28621 ggccggcact gcgtctgcta cccggtctcc ggcggccggc tgatcagctt cgctgccacc
    28681 accggcggta ccgcgctccc gggcgaatcc tggaccgcgc caggtgaccc ggacgaggcg
    28741 gccgaggcct accgggggtg gcaccccacg gtcacccggc tgctcggggc gggcggcggt
    28801 atcggctgct gggcgctgca cgatcgcgag ccgctggcgc gctggtcctc cgacgccctc
    28861 acgctgctcg gcgacgcggc gcatccgat
//
