LOCUS       NZ_CP117709            26317 bp    DNA     linear   CON 25-MAR-2024
DEFINITION  Streptomyces sp. MMBL 11-1 chromosome, complete genome.
ACCESSION   NZ_CP117709
VERSION     NZ_CP117709.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MMBL 11-1
  ORGANISM  Streptomyces sp. MMBL 11-1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8003288)
  AUTHORS   Choi,S.S., Park,H.S. and Lee,H.K.
  TITLE     Whole genome sequence of Streptomyces sp. MMBL 11-1 from novel
            marine Actinomycets
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8003288)
  AUTHORS   Kim,E.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2023) MMBL, Inha university, 105, Building C, 100
            Inha-ro, Incheon, Michuhol-gu 22212, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-SEP-2021
            Assembly Method                   :: BLASTN v. 2.7.1+
            Assembly Name                     :: De novo
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.91x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028622875.1-RS_2024_03_25
            Annotation Date                   :: 03/25/2024 07:47:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,554
            CDSs (total)                      :: 7,455
            Genes (coding)                    :: 7,322
            CDSs (with protein)               :: 7,322
            Genes (RNA)                       :: 99
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 134
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 134
            Pseudo Genes (frameshifted)       :: 57 of 134
            Pseudo Genes (incomplete)         :: 101 of 134
            Pseudo Genes (internal stop)      :: 16 of 134
            Pseudo Genes (multiple problems)  :: 36 of 134
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:00:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3146040
            Orig. end                         :: 3172357
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117709.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from professor Eung-Soo Kim
            (In-ha university).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26317
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="15"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26317
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26317
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16317](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16317)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(619..2466)
                     /locus_tag="PSQ21_RS13510"
     CDS             complement(619..2466)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0017004 - cytochrome complex assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380421.1"
                     /locus_tag="PSQ21_RS13510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome c biogenesis protein ResB"
                     /protein_id="WP_274030754.1"
                     /transl_table=11
                     /translation="MSKSNGTETRQREDERAQGSAHGAAGERLSTAPREERADTGAGVP
                     AMSVIGWARWFWRQLTSMRVALILLFLLSLGAIPGSLIPQTSVDDMKVQAFKDQHTTLT
                     PIYEKLQLFDVYSSVWFSAIYILLFVSLIGCIVPRTGQFVGQLRSRPPGAPKRLTRLPA
                     YTTWRTEAEPEEVREAALAVLRKRRFRAHETGDAVAAEKGYLREAGNLVFHIALIVMLV
                     AFASGELFKSEGGKLIVEGDGFSNTLTQYDDFKSGSLYDSDSLAPFSFVLDEFVGTYEK
                     SGPQRGTPRTFEARVTYTEGAEGAERKDVIKVNEPLVVDGTKIYLIAHGYAPVVTVRDG
                     RGKVVSRSAVPLLPIDNNITSSGAIKVMDGYKDKNGKKTQLGFKAFFVPTFAGEGKGQM
                     FSQFPALDFPVLALSAYHGSLGVDSGLAQNVYQLDTSKMKEFKGEDGELLKKMMMPGEK
                     LDLPDGGGSITFDGVEEWASFQISQQPGNGWALGGSVAAIAGLAGSLFIQRRRVWVRAV
                     RGADGVTVVEMAGLGRSESARLPEELGDLSAAVVATAPVAAEAPDTPKEPETPKAPDTP
                     KDPDTTDGPGTTDATTDATNEAGSRPVHPAEAPVEGAEK"
     gene            complement(2471..3193)
                     /locus_tag="PSQ21_RS13515"
     CDS             complement(2471..3193)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0017004 - cytochrome complex assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104332.1"
                     /locus_tag="PSQ21_RS13515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome c biogenesis protein CcdA"
                     /protein_id="WP_274035751.1"
                     /transl_table=11
                     /translation="MSGTLLLSLPIALLAGLISFFSPCVLPLVPGYLSYVTGVSGTDLA
                     EARRGRVVAGAILFVLGFTAVFVSGGALFGYFGRELQVHAELFNRILGVLMILMGVFFM
                     GLLPGVTQREFRFHKRPVTGLAGAPLLGALFGIGWTPCIGPTFAAVSTLAFTEGTAGRG
                     AILTVAYCLGLGVPFVLAAVAFRKALGAFGWVKRHYAWVMRIGGGMMIVTGILLLTGVW
                     ATLMQHMQSWSSGFVVGI"
     gene            complement(3258..3860)
                     /locus_tag="PSQ21_RS13520"
     CDS             complement(3258..3860)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961611.1"
                     /locus_tag="PSQ21_RS13520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_274030755.1"
                     /transl_table=11
                     /translation="MSFGRASRRRFTLLAATAVAGALTLSACGDGNTTGGGGNTNFVTG
                     SGGISTVAKGDRVAAPKLDGNGLDGKPLDLADYRGKVVVLNVWGSWCGPCRLEAKYFAK
                     VSKETADQGVQFLGINTRDAQRDAAINFEKDYGVEYPSFYDPIGKLILRFPKGTLNPQA
                     IPSTVVIDRDGKIAARTLQALDADELREMIDPIIAEK"
     misc_feature    complement(3860..3875)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     gene            complement(3928..5214)
                     /locus_tag="PSQ21_RS13525"
     CDS             complement(3928..5214)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460422.1"
                     /locus_tag="PSQ21_RS13525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274030756.1"
                     /transl_table=11
                     /translation="MRDMNRRGLLGAGLGAAAAIGLAGCGASGSSGDGGSGPGGKGDTG
                     GNGNGNGNGSGNGSGSGNSAPKSKVRLIGDGSTADTGKQPNQPQAPVPLEPGQKPPQFV
                     IFSWDGAGEVGNGLFPRFLELAKEHDAAMTFFLSGIYLLPESKKSLYRPPNNRRGASDI
                     GYLTDDHVKDTLTYVRQAWLDGHEIGTHFNGHFCGGSGSVERWTPAQWHSEINQAVSFV
                     TEWRTNTGWENEDPLPFDYRKELIGGRTPCLLGQDNLLPTARKLGWRYDASSPGGRQIW
                     PVKRGGVWDLPLQAMPFPGHSFEVLSMDYNILANQSKNSTKGMPSRYPGWRTQATGAYL
                     AGFRRAYESNRAPFFIGNHFEEWNGGIYMDAVEEVIKKVADKDDVRLVSFRQYVDWLDV
                     QDPAVLAKLRTLDVGQAPAGGWNSFFKQA"
     gene            complement(5712..6500)
                     /locus_tag="PSQ21_RS13530"
     CDS             complement(5712..6500)
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980984.1"
                     /locus_tag="PSQ21_RS13530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_274030757.1"
                     /transl_table=11
                     /translation="MSDITNGDVTNGENGENGENGEDARGIASRGHVNRDEQLTVVHVV
                     RHGEVHNPDGVLYGRRPGYHLSDLGRQMADRVAGHLEKRDITHVVASPLERAQETAAPV
                     AKAHGLDLATDVRLIEAANVFEGKTFGVGDGALRKPDNWKHLTNPFKPSWGEPYIEQVV
                     RMMGALDAARDAARGHEAVCVSHQLPIWILRSFVERRRLWHDPRKRQCTLASLTSFTYR
                     GDRIVSVGYSEPARDLVPVHLLAGAKPVKGKPGQSKAFGA"
     gene            complement(6497..7768)
                     /gene="hemL"
                     /locus_tag="PSQ21_RS13535"
     CDS             complement(6497..7768)
                     /EC_number="5.4.3.8"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0042286 - glutamate-1-semialdehyde
                     2,1-aminomutase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (30-353). E-value: 4.9e-73.
                     Score: 238.0. Matches aSDomain:
                     nrpspksdomains_PSQ21_RS13535_Aminotran_3.1"
                     /codon_start=1
                     /gene="hemL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007264728.1"
                     /locus_tag="PSQ21_RS13535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate-1-semialdehyde 2,1-aminomutase"
                     /protein_id="WP_274035752.1"
                     /sec_met_domain="Aminotran_3 (E-value: 9.7e-84, bitscore:
                     280.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDRASLVTPGGVNSPVRAFRAVGGTPRFMVSGTGPYLTDADGRE
                     YVDLVCSWGPMILGHSHPEVIAAVQEAVSRGTSFGTPGEGEVALAEEIVARIDPVEQVR
                     LVSSGTEATMSAIRLARGFTGRAKVVKFAGCYHGHVDALLAAAGSGVATFGLPDTPGVT
                     GATAGDTVVLPYNDLDAVRAAFAAHPGEIACVITEASPGNMGVVPPAEGFNAGLKELCA
                     ANGALYISDEVMTGFRTSKAGWYGVDGVRPDLMTFGKVMGGGFPAAAFGGRGDVMAHLA
                     PAGPVYQAGTLSGNPVATAAGLAQLRLLDDAAYAKIDAVSAELRSLVGDALTKAGVAHT
                     VSAASNMFSVFFTDEPVRDYDDAKKQDVFRFTAFFHAMLEQGVYLPPSAFESWFVSTAH
                     DERAVERIAAALPAAARAAAEATA"
     aSDomain        complement(6710..7678)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PSQ21_RS13535_Aminotran_3.1"
                     /evalue="4.90E-73"
                     /label="PSQ21_RS13535_Aminotran_3.1"
                     /locus_tag="PSQ21_RS13535"
                     /protein_end="353"
                     /protein_start="30"
                     /score="238.0"
                     /tool="antismash"
                     /translation="VSGTGPYLTDADGREYVDLVCSWGPMILGHSHPEVIAAVQEAVSR
                     GTSFGTPGEGEVALAEEIVARIDPVEQVRLVSSGTEATMSAIRLARGFTGRAKVVKFAG
                     CYHGHVDALLAAAGSGVATFGLPDTPGVTGATAGDTVVLPYNDLDAVRAAFAAHPGEIA
                     CVITEASPGNMGVVPPAEGFNAGLKELCAANGALYISDEVMTGFRTSKAGWYGVDGVRP
                     DLMTFGKVMGGGFPAAAFGGRGDVMAHLAPAGPVYQAGTLSGNPVATAAGLAQLRLLDD
                     AAYAKIDAVSAELRSLVGDALTKAGVAHTVSAASNMFSVFFT"
     misc_feature    7850..7865
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.91"
                     /tool="antismash"
     gene            8101..8685
                     /locus_tag="PSQ21_RS13540"
     CDS             8101..8685
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016326956.1"
                     /locus_tag="PSQ21_RS13540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_073746161.1"
                     /transl_table=11
                     /translation="MHRGGGVGEGTDDLGPEPARRGRHRRRAERAQSRGADSTPPPGTR
                     SGGGMGVTYKYFGAPDGATAARVPISMRPEELGGDELGMGGMFTKIKPETVAAMVLTGI
                     QGIPLHKVPPLELVVLHPDYAVVKLPMTVVDPLRGVGEESVGAAAFIWSTVPDRGGPRD
                     AFNVYQLLHEWQDFSHRLHDAGHQAYCLVWP"
     gene            complement(8794..9912)
                     /locus_tag="PSQ21_RS13545"
     CDS             complement(8794..9912)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612040.1"
                     /locus_tag="PSQ21_RS13545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_274030758.1"
                     /transl_table=11
                     /translation="MDPHGSTAQRFPLVARFRPACLPLPKRVRALVDLADTAMVETDQG
                     VASSVYNQTALIASDLGLPDLAREMCREHAAAYLHACPLPAMSAIRGLEPVVNLARLQI
                     RGGHADAGRQRLLDLYAAVEAGTPARFGGVAIPADLTATDKDRHEVVAWLWRVLLADGT
                     RALTAEGRWSEALAHMETHRGVGRRMLDGRQVAVLASLAAKDTAHAATLLAATVPGEPW
                     EQTVTACLTAQWRRDAGRPAGVHLADLADAYLERKAEPGMTVFDIRLGLTVLDMVGSPD
                     LPTAYRIAEDLHRRATEAEDGYAARENLANSLFIELATNRQEQDCRTLVRACALGAEAL
                     PDQMQGALSAALRAADSVIRKSLVPSTTLSPR"
     gene            complement(10001..12079)
                     /gene="fxlM"
                     /locus_tag="PSQ21_RS13550"
     CDS             complement(10001..12079)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763664.1"
                     /locus_tag="PSQ21_RS13550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_274030759.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.6e-23, bitscore:
                     82.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 3.3e-44, bitscore: 149.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDWQQHNITFIDRESARHTIDERLGPALITAETAGQLTGWWFM
                     NKQPWPLRYLADEPSPIIESLLSDLVGDGAVVSWLPAVYEPESEAFGGPDAMDTAHGLF
                     HSDSRHLLTYQPSPDHLGRRETTVLLASAMMRGAGLDWFEQGDVWAKAATLRPVTSALS
                     HARVAELIPFVRKLMSADAHGLSLRDGPLHGYGAWVSAFERAGDTLAGLDKRGALTRGL
                     RAVITHHIIFHANRAGLLRDDQSTLYNIAREAVMGTSDHTASPTGPTTNADSVKRVGTD
                     MVTTPTSDAERLRNVLVDQLRADGNARTPAVESALRTVPRHVFVPDVPLEDAYANAPVH
                     IKYDTDGSSISCASQPGVVALMLDQLDARQGERVLELGAGTGYNAGLLAHLVGESGHVT
                     TLDVDDDLVEGARAHLSAAGTTNVEAVTRDGALGYAEGAPYDRIIATVGAHGVPHAWLQ
                     QLAPGGRLLVPQRLKGTVSRSIAYEQRDGRWMSLGSEMNTFMPLRRGIADDDRRVIPLS
                     TDGTVRLQAPAGQTIDAEALDGVLHEPRTEEWTGMTVRAMESPEWMELFLTCSLPSGLI
                     RMLFPQAAKGTLLTEDPYPSSTATVDKGAVTYLARRLSEKKTSEGGKLWEFGVIGHGPG
                     SDELAARVAAAIRAWDLEYRGREATFEIQPLDAPSIEQRAGLFALDTPLNRIIVDWS"
     gene            complement(12101..13366)
                     /locus_tag="PSQ21_RS13555"
     CDS             complement(12101..13366)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006383504.1"
                     /locus_tag="PSQ21_RS13555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_274030760.1"
                     /sec_met_domain="LANC_like (E-value: 5.2e-43, bitscore:
                     145.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVLPTLGLVGAVAARLANPGTAPSVLQTRRQHLAYGPPGIALLH
                     IERAANGLGPWQHAHGWLAAASHGFLTSGPDSHPFYGVPAFAHALACAADHLPDSYQRA
                     LGAMDRQIEIDVRRRLDAAHRRIDSRCLPQLAEYDTIRGLTGYGAYLLRRNSGSPVVRA
                     VLDYCVRLTEPIRQAGEDLPGWWTATGPSGSPDERFPGGHANTGTAHGIAGVLALLALA
                     ARKGTVTDGHLRALRTILTWLDCWQQETGRGSTWPYWVTRSELRTGRRAASKLRRPSWC
                     YGTAGLARAQQLAALATSDIERQITAESVLAAALTDPDQLGATTDHGLCHGFAGLAHIA
                     GRTAADAHPSTAGRLRAAIPGLLAAVCPVDRDLERAATALVSGTGAGPGLLDGAAGVAL
                     ALLAADTAAPPQSAWDSCLLIA"
     gene            complement(13363..16317)
                     /locus_tag="PSQ21_RS13560"
     CDS             complement(13363..16317)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543779.1"
                     /locus_tag="PSQ21_RS13560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_274030761.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.1e-200,
                     bitscore: 664.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.2e-18,
                     bitscore: 65.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.5e-25, bitscore:
                     87.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWLRAVWADQHIADAVEHSSPALAMQVRAVCTAENPPHRDARRA
                     ALSVARYLLRAQHRATPFGLFAGVTTAAFGPRVHVAWGEEHVAVGRAGAEWLAAVVERL
                     EFCPELLDRLPVVVNNTVTSRGDRLIVPFQPDANDDRMRAVEASLALTEPVRAVLAEAR
                     TPIRCGDLTEKLRAEFPEAGTEKVHCLLVELVRRRVLITSLHAPSTETDALGYLLGQLD
                     AIGVDDLASVADTAREMHAVRMGLEAYATRCGRDSTAARMRALAPGLRRHPAAVDLRLD
                     ARLVLPEEVAREVERVAFVLTRVSTRPYGAAEWNAYHQRFYERYGIGTMVPLAEVVADS
                     GTGYPDGYPGSPAGPGRPRVSARDDALVRLAQGAALDGCDEVVLTDEQIDLLEAGPDEP
                     RLPPHLEVGVRVHAASPEDLQRGRFRLEVVSVSRGAGVSTGRFLDVLAPSARQALAAEL
                     ADLPAADSDTVPAQLSFPPLLPESTHVTRSPQMLPTVISLQEHRAPKDTVLTPKDLAVG
                     CDGRRMYLAAPERGHRVEAVGMNALNLHTHAPPLARFLTEVSRAQCAQVTAFDWGVAAA
                     MPFLPRLRYGRTVLSPARWRLEASELPGRARPRTEWDTALSEWRAQRGSPRRVLLVEDD
                     RRLFLDLDEAGHRTLLLRHLDRSHQAVLMEAPEPETYGWCGGRAHEIVVPLRATRSPSW
                     PPLPVPTQARVLSSDQLQTPAASSVLLAALYGDPRRQDTLLSQHLPGLLERLGNPPWWF
                     IRFRDPEQHLRVRIALPDRRTFAQTARTVSAWADDLRSAGLLADLRYPTSYREMGRWGS
                     GAAWEAAEQVFRADSRSVLAQLAEPQRPAQRALVAAHSVAIASAFLGSAEAAMRWLADH
                     VSPTAPASVPRPQFSEAVRLANPADDWAALREVQGGDAIVSGWAERDAALAAYRLHLPG
                     PDAQGIAVDDVLASLLHVHFVRHVAVNFPEEEVCLYLARAAALAWTARTSRRSA"
     misc_feature    complement(14512..14514)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(15697..15972)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PSQ21_RS13560_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.00E-21"
                     /identifier="RREFam001.1"
                     /label="PSQ21_RS13560"
                     /locus_tag="PSQ21_RS13560"
                     /protein_end="207"
                     /protein_start="115"
                     /score="65.4"
                     /tool="antismash"
                     /translation="VVVNNTVTSRGDRLIVPFQPDANDDRMRAVEASLALTEPVRAVLA
                     EARTPIRCGDLTEKLRAEFPEAGTEKVHCLLVELVRRRVLITSLHAP"
     gene            complement(16543..16722)
                     /locus_tag="PSQ21_RS13565"
     CDS             complement(16543..16722)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825826.1"
                     /locus_tag="PSQ21_RS13565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_016825826.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.9e-13, bitscore:
                     47.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSTVVPSRTEVRPQIPGASDGFDLDVSLVEIADPAGLVNLTDD
                     NCGSTCGACTTNVA"
     gene            complement(17234..17680)
                     /locus_tag="PSQ21_RS13570"
     CDS             complement(17234..17680)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763666.1"
                     /locus_tag="PSQ21_RS13570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_274030762.1"
                     /transl_table=11
                     /translation="MPVPKKTVETVLTSHPTYSEVFPCVPSTAETGRRLVRGVLGMWHL
                     DVLADRAELIVTELIANAARHTPCPEVCFVVGRPTATRVRVGIVDEEPSRLPELSHAGE
                     EDESGRGLFLVEAVADRWGCDLQSAGGRLRGKEVWAELHTEGDE"
     gene            17907..19190
                     /locus_tag="PSQ21_RS13575"
     CDS             17907..19190
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000004.1"
                     /locus_tag="PSQ21_RS13575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_274030763.1"
                     /transl_table=11
                     /translation="MDAIRNTVLEAWMIEHGYSSNSLADAVNRAVEKLTGHVGGLDGSS
                     VRAWKAGRVTWPKSATRTALEVVTGLPAVALGFVPRGRPSPTPAPSQQEEPEMKRRALV
                     GGIAAAAAAAASPGTASPRRIGMSDVSRLNKRFAEIIASDHRHGGQPGIEERAAALADE
                     ALNLQNAGSATQRVRSSLYASGAAFRSSAMWAAIDGRRYDVAKAHMREAQALAEMSGDQ
                     AIKFRIWSHAGTMYRHMGRPADACAANDVARNLHLTRRDPLFASLGLARQGAIHGTAQN
                     RTDTRRAFEQAQDAMLRADPADHRPVWLLAFYDQAELDSLALSAYLALGDYPTAEYHAH
                     RCLSSLRPHMARSRAITTTRLAHALLAQGAAEAATTTAMKVPVDAATRHARVSRMLQEF
                     GAALRATTPRSTTVQNWTEHTTTWKTAA"
     misc_feature    18117..18119
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18132..18134
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19187..19726
                     /locus_tag="PSQ21_RS13580"
     CDS             19187..19726
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337821.1"
                     /locus_tag="PSQ21_RS13580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_274030764.1"
                     /transl_table=11
                     /translation="MTTALAPELRTFTNLDTARGDLLDVYAEVRAPLLHLPNYAVTAFG
                     ERIDRHSTEPGFTAVLAYAAGQPVGYAYSNTIEHGDRYWQRTSPTPAEKYTKRPAAALK
                     EIGVHPAWRKTGTARRIHDALLATRDEPHVTLMVNSAAGDGKVHSLYKSWGYEDIGQSQ
                     PSPASPVLTVMIHTNR"
     gene            complement(19636..19995)
                     /locus_tag="PSQ21_RS13585"
     CDS             complement(19636..19995)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="PSQ21_RS13585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_337961671.1"
                     /transl_table=11
                     /translation="MQWSEYTTAERMKALRGAMTQEQLAEAAAVSVGVVRKLERGGRTS
                     LSSLLSIANAPWAAEVQGALWATPAPASRCARTRTCSAIPNLRGGQRLVWIMTVSTGEA
                     GDGWLCPMSSYPHDL"
     misc_feature    complement(19849..19851)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19924..19926)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20084..20746)
                     /locus_tag="PSQ21_RS13590"
     CDS             complement(20084..20746)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761661.1"
                     /locus_tag="PSQ21_RS13590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_274030765.1"
                     /sec_met_domain="HAD_2 (E-value: 1.3e-08, bitscore: 33.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHSRGVASGREERGLILDFAGVLTASPVDVHRAWCVSEGLAPGA
                     WRSTLNDHPEGRRLYTALEIGEIGQTEWNQGTAALLGEHVDPVNLMGRAWAEVPVSRRM
                     DALARSARAAGHRLALLSNSFGLDPFNPYEHVGVWDVFDVHVVSELVGLAKPDPSIYQL
                     ALDLIGLPAERCVFVDDHAINLPPAAELGIATVHATDEDTAVAELEALLGLTAASVT"
     gene            complement(20998..21627)
                     /locus_tag="PSQ21_RS13595"
     CDS             complement(20998..21627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460409.1"
                     /locus_tag="PSQ21_RS13595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR03086 family metal-binding protein"
                     /protein_id="WP_274030766.1"
                     /transl_table=11
                     /translation="MTQTIGELLEAAADRALPVVRGIDDGQLGGGTPCAEYDVRALVNH
                     LFQVVVNFQALAAREKVDFGQVPEFVAGDWRARFGAETARLVEAWSVPGVEEGTTGQMG
                     LPARTVGLMVLGDLTVHAWDLARATGADFVPEERVLDELGPGLAALAPQAREMKVFGEP
                     FPVEEGATAFERLLAVTGRDPGWRPGGAGGVTGATGTAGAAGAVRS"
     gene            21718..22539
                     /locus_tag="PSQ21_RS13600"
     CDS             21718..22539
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961605.1"
                     /locus_tag="PSQ21_RS13600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_274030767.1"
                     /transl_table=11
                     /translation="MAAGPRRDTRGIVDAPDLFAHVRFRRREPAAGLRPYLEHYWLIDW
                     DLTEPYAAHVVPHPSVNLVFQRYEAGDGARERSGYAEVAGVDPGLFARKLAGRGRVCGV
                     QFRPGGFRPFAPGHPVSAWTGLRSDAAGALRLPPPVRAVLDPDDEDARVAALDAFLLAL
                     EPRPDPRATLAMAVVDRVRTDRTVLRADHLARDAGLSARALQRLFAAYVGVGPKWVILR
                     YRVHEALERAGSDPAVDWARLAADLGYSDQAHLVRDFTATVGVPPTAYAPR"
     gene            22731..23465
                     /locus_tag="PSQ21_RS13605"
     CDS             22731..23465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968386.1"
                     /locus_tag="PSQ21_RS13605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Mut7-C RNAse domain-containing protein"
                     /protein_id="WP_274030768.1"
                     /transl_table=11
                     /translation="MNGPEITLEVAPELRLFAPHDRRGGPTPLVTDGSSTLGHVIESLG
                     VPLTEAGTLLVNGAPVARSHVPGPGEHVDVRAVERPQQVPGAPLRFLLDVHLGTLARRL
                     RLLGVDAAYESEDIGDPALAALSARERRVLLSRDRGLLRRREIWAGAYVYSDRPPEQLR
                     DVLGRFAPALAPWTRCTACNGTLAGAAKDSVSGLLEHGTQEAYDVFAQCTACSRVYWRG
                     AHHGHLETIVSEAMAEFGGAPA"
     gene            23677..24435
                     /locus_tag="PSQ21_RS13610"
     CDS             23677..24435
                     /NRPS_PKS="Domain: PKS_KR (7-160). E-value: 6.1e-12. Score:
                     37.8. Matches aSDomain:
                     nrpspksdomains_PSQ21_RS13610_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552217.1"
                     /locus_tag="PSQ21_RS13610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_274030769.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-33, bitscore:
                     114.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATPIAVVTGASSGIGAATARTLAAAGFRVVLTARRKDRVEALA
                     AEITEAGHQATAYPLDVTDRAAVDEFATAFRSLAVLVNNAGGALGADPVATGDPADWRQ
                     MYETNVIGTLNVTQALLPALTASGDGTIVILSSTAALSAYEGGGGYVAAKHGEHVLAET
                     LRLEIVGTPVRVIEVAPGMVRTEEFATTRFRGDTEKAAKVYAGVDAPLTAEDVADTIGW
                     AVTRPSHVNIDLLVVRPRAQASNTKVHRTG"
     CDS_motif       23698..23787
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PSQ21_RS13610_0001"
                     /evalue="4.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="PSQ21_RS13610"
                     /protein_end="37"
                     /protein_start="7"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VVTGASSGIGAATARTLAAAGFRVVLTARR"
     aSDomain        23698..24156
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PSQ21_RS13610_PKS_KR.1"
                     /evalue="6.10E-12"
                     /label="PSQ21_RS13610_PKS_KR.1"
                     /locus_tag="PSQ21_RS13610"
                     /protein_end="160"
                     /protein_start="7"
                     /score="37.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVTGASSGIGAATARTLAAAGFRVVLTARRKDRVEALAAEITEAG
                     HQATAYPLDVTDRAAVDEFATAFRSLAVLVNNAGGALGADPVATGDPADWRQMYETNVI
                     GTLNVTQALLPALTASGDGTIVILSSTAALSAYEGGGGYVAAKHGEHVL"
     gene            24802..25413
                     /locus_tag="PSQ21_RS13615"
     CDS             24802..25413
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328242.1"
                     /locus_tag="PSQ21_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_274030770.1"
                     /transl_table=11
                     /translation="MKLVVQEFLTLDGVSQGPGSPDEDTSDGFTRGGWFVPHLDEEFER
                     QAGEWLGEADAFLFGRRTYENFARDWPRMTDHPFAGILNGLPKYVASNTLTEATWDPTT
                     ILSGDIPAQVAEVKRRPGRDLQIHGSARLAQSLLAAGLVDELRLAIAPVVVGEGRRLFP
                     DGGAPAGLRLLSHRTTPAGVSVHVFTATGPPDYATYGGGA"
     misc_feature    25757..25772
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.49"
                     /tool="antismash"
ORIGIN
        1 agtacgagtg cagggcgggc accagctggt cgctgtcggt gtagagcgtc gtgaccgcga
       61 tgccgaggtc cagcaggacg gtggtgacca gcggaaggcc gatccagcgg acgttcttct
      121 tcagggcgag cagcaccagg taggagccga ccgccaccgt ggagaaggtg atggagaact
      181 cgtacatgtt ggcccagggg gcccgctgca ccgacagggc gcgggtggcg acgccgctcg
      241 cctcgacgag gaacgccacc acggtcagcg agaccgcgat ccggccccac aggtcgccct
      301 tgaacgtgcc gccggccgcg cccgggccgt cgggcacgtc gcgcgtcccg gtggcggagc
      361 gggtgatgac ctcggggcgg tccagcacgg ccgtgccgcc ggcccgtgcc ttccccgcgg
      421 tggcggcgga ggcggcggag acgggagcac cggctccggg ggcggacagc gcggcggccg
      481 tgcggccgac cttgctgcgg ctgccgagga cccactccgc gatatgcgcg aagaaggcca
      541 gggtgtagac ggccatcgac gaatagatca gcacattgct ggtgttcgcc agagtctcgt
      601 tggttgcggc ggcgagattc acttctcagc cccttcgaca ggtgcttcgg caggatgtac
      661 gggccggctc ccggcctcgt tcgtggcatc ggtcgtggcg tcggtcgtgc cgggcccgtc
      721 cgtcgtgtcc ggatccttcg gtgtgtccgg agccttcggt gtctccggct ccttcggtgt
      781 gtccggggcc tccgcggcga cgggggcggt ggcgaccacg gcggccgaca ggtcgcccag
      841 ctcctcgggg agcctcgcgg actcgctacg gcccaggccc gccatctcca cgaccgtgac
      901 gccgtcggcg ccccggaccg cccgcaccca cacgcggcgg cgctggatga agagcgagcc
      961 ggcgaggccg gcgatggcgg cgacggatcc gccgagcgcc cagccgttgc cgggctgctg
     1021 cgagatctgg aagctggccc actcctcgac gccgtcgaag gtgatggatc cgccgccgtc
     1081 gggcaggtcc agcttctcgc ccggcatcat catcttcttg aggagctcgc cgtcctcgcc
     1141 cttgaactcc ttcatcttgg acgtgtcgag ctggtagacg ttctgcgcca gcccggagtc
     1201 gacgccgagg gagccgtggt aggcgctgag cgccagtacg gggaagtcca gggcggggaa
     1261 ctgcgagaac atctggccct tgccctcgcc ggcgaaggtc ggcacgaaga aggccttgaa
     1321 tcccagctgg gtcttcttgc cgttcttgtc cttgtagccg tccatcacct tgatggcgcc
     1381 ggacgaggtg atgttgttgt cgatcggcag cagcgggacc gcggaccgcg agacgacctt
     1441 ccccctgccg tcccggacgg tgaccacggg ggcgtagccg tgggcgatca gatagatctt
     1501 ggtgccgtcc acgacgagcg gctcgttgac cttgatgacg tccttgcgct ccgcgccctc
     1561 ggccccctcg gtgtacgtca cccgggcctc gaaggtccgc ggggtgccgc gctgggggcc
     1621 gctcttctcg tacgtaccga cgaactcgtc gagcacgaag ctgaacgggg ccagcgagtc
     1681 ggagtcgtag agcgagccgg acttgaagtc gtcgtactgg gtgagcgtgt tggagaagcc
     1741 gtcgccctcg acgatcagct tgccgccctc ggacttgaag agctccccgg aggcgaaggc
     1801 caccagcatc acgatcaggg cgatgtggaa gaccaggttc ccggcctcgc ggaggtagcc
     1861 cttctcggcg gcgaccgcgt cgcccgtctc gtgcgcccgg aagcgccgct tgcgcaggac
     1921 cgcgagggcc gcctcgcgga cctcctcggg ctcggcctcc gtgcgccagg tggtgtacgc
     1981 gggcagccgg gtcagccgct tcggcgcgcc cggcgggcgg ctgcgcagct ggccgacgaa
     2041 ctggccggtg cgcggcacga tgcagccgat gagcgagacg aacagcagga tgtagatcgc
     2101 ggagaaccac accgagctgt agacgtcgaa gagctggagc ttctcgtaga tcggggtcag
     2161 ggtggtgtgc tggtccttga aggcctgcac cttcatgtcg tcgacgctgg tctgcgggat
     2221 cagcgacccc gggatcgcgc cgagggagag caggaagagc aggatcaggg ccacccgcat
     2281 cgaggtgagc tgacgccaga accagcgcgc ccagccgatc acgctcatcg cgggtacgcc
     2341 cgccccggtg tcggcgcgct cctcgcgggg cgcggtggag agccgttcgc ccgccgcgcc
     2401 gtgggcggag ccctgggcgc gctcgtcctc gcgctgccgc gtctccgtgc cgttcgactt
     2461 gctcatgaac tcagatccct acaacgaagc cgctggacca gctctgcatg tgctgcatca
     2521 gcgtggccca cacaccggtc agcagcagga ttccggtcac gatcatcatg ccgccgccga
     2581 tccgcatcac ccatgcgtag tggcgtttga cccagccgaa cgcgccgagc gccttgcgga
     2641 aggcgaccgc ggcgaggacg aacgggacac cgagaccgag acagtacgcg acggtcagta
     2701 tcgcgccgcg tccggcggtg ccctcggtga acgcgagcgt gctcacggcg gcgaaggtcg
     2761 gaccgataca gggggtccag ccgatcccga agagcgcgcc cagcagcggt gcgccggcca
     2821 gaccggtcac cggccgcttg tggaaccgga actcgcgctg cgtcaccccc ggcaggagcc
     2881 ccatgaagaa gacccccatg aggatcatca ggacgccgag gattctgttg aacagctcgg
     2941 cgtgtacctg gagctcccgg ccgaagtagc cgaagagggc cccgcccgag acgaagacgg
     3001 cggtgaagcc gagcacgaag aggatggcgc ccgccacgac gcggccacgg cgcgcctcgg
     3061 cgaggtcggt gccgctgacc ccggtgacgt aactcagata gccgggcacg aggggcagca
     3121 cgcacgggga gaagaacgag atgaggccgg ccagcagggc gatgggcagg gacagcagaa
     3181 gggtcccgct catgacggtc tcgttgtacg cggccagcgt gacggccccg tggtgggcgg
     3241 cgagcgtggt caccggatca cttctccgcg atgatcgggt cgatcatctc gcgcagctcg
     3301 tccgcgtcga gcgcctggag cgtgcgggcc gcgatcttcc cgtcccggtc gatgaccacg
     3361 gtggacggga tggcctgcgg gttcagggtg cccttgggga agcggaggat gagcttgccg
     3421 atcgggtcgt agaagctcgg gtactcgacc ccgtagtcct tctcgaagtt gatcgcggcg
     3481 tcacgctggg cgtcacgggt gtttatcccg aggaactgga cgccctggtc cgccgtctcc
     3541 ttcgagacct tcgcgaagta cttcgcctcc aggcggcagg gaccgcacca ggagccccag
     3601 acgttgagca cgacgacctt gccccggtag tccgcgaggt cgagcggctt gccgtccaga
     3661 ccgttgccgt cgagcttcgg cgccgccacc cggtcgccct tggcgacggt ggagataccg
     3721 ccgctgccgg tgacgaagtt ggtgttgccc ccgcctccgg tcgtgttgcc gtcaccacac
     3781 gcggacagcg tcagggcacc ggccactgcg gtggcggcga gcagggtgaa gcggcgtcgg
     3841 gatgcgcggc caaagctcat gtgaaaagtt tcgcatggca gtttccgggt tcccccgcgc
     3901 ccccctcggt gcccgtaaag ccccttgtca agcctgttta aagaaggagt tccaaccgcc
     3961 ggcgggcgcc tgtccgacgt ccagcgtccg gagcttggca agcacggcgg gatcctggac
     4021 gtcgagccag tcgacgtact gccggaacga gacgagacgc acgtcgtcct tgtccgccac
     4081 cttcttgatc acttcttcca cggcgtccat atagatgccg ccgttccact cctcgaagtg
     4141 gttgccgatg aagaacggcg cacgattcga ctcgtacgcg cgccggaaac cggcgagata
     4201 cgccccggtg gcctgcgtgc gccagcccgg ataacgcgag ggcatgccct tcgtcgaatt
     4261 cttcgactga ttggcgagga tgttgtagtc catcgagagc acctcgaagg agtgcccggg
     4321 gaacggcatc gcctgcagcg gcagatccca gacgccgccg cgcttcacgg gccagatctg
     4381 acggccgccg ggcgagctgg cgtcgtagcg ccagcccagc ttgcgggcgg tcggcaggag
     4441 attgtcctgg ccgagcaggc agggggtacg gccgccgatc agttccttgc ggtagtcgaa
     4501 cggcagcggg tcctcgttct cccagccggt gttcgtccgc cattccgtga cgaacgacac
     4561 agcctgattg atctcgctgt gccattgggc gggcgtccag cgctccacgg atccggaacc
     4621 gccgcagaaa tgcccgttga agtgggtgcc gatctcgtgg ccgtccagcc acgcctgacg
     4681 cacgtacgtc agcgtgtcct tgacgtgatc gtcggtgaga tagccgatgt cggaggcgcc
     4741 gcggcggttg ttcggcgggc ggtagaggga tttcttcgac tcgggcagca gatagatccc
     4801 ggagaggaag aacgtcatgg ccgcgtcgtg ttccttggcc agttcgagaa agcgcgggaa
     4861 gagcccgttg ccgacctcgc ccgcgccgtc ccaggaaaag atcacgaact gcggcggctt
     4921 ctggccgggt tccagcggga cgggcgcctg gggctggttg ggctgtttgc cggtgtcggc
     4981 ggtcgaaccg tcaccgatca gccggacctt gctcttcggc gcgctgtttc cgctgccgct
     5041 gccgttgccg ctgccgttgc cgttgccgtt gccgttgccg ccggtgtcgc ccttgccgcc
     5101 cgggccggac cctccgtcgc cggaggagcc cgaggcgcca cagccggcga gtccgatcgc
     5161 ggccgcggcg ccgagccccg ccccgagcag gccccttcga ttcatgtcgc gcataccgtc
     5221 cccatctgcg gtcgttttat ctcatgccca tacaaactgc tgaagggtta gatgaggcgc
     5281 gtaacacgtc ggttccgtgc atttggggac tttcttcacg cttcaccttg ccgaccgtcc
     5341 aaccgtccgg ccgatcatga cgcgacgccc gtacgacacc cgtacaccct tgcgggcagc
     5401 tctgatgggg ggacgcaggg gtggccgtcc gcagttctcc cgtgggccga caggcggcgg
     5461 cttccctgga aagtcgaact catgcgcgga cgcggaggcg cgcccggctg cgcctcacgg
     5521 tggacggtgt gggtgaagcc gcgtaccggg cgggggaagg ggacgaaacg gggacgggac
     5581 cggccgcccg ttgctcaggc gaccggtccc gtcatgtccc ggggatccgt atgtcccgca
     5641 gataccgcat atcccgcatg tccgcttgcc cgctcgcctt acggaggctg cggctgcggc
     5701 tttgccttcg gctacgcgcc gaacgccttg gactgccccg gcttcccctt caccggcttg
     5761 gcgccggcca gcaggtgcac gggcaccaga tcccgggccg gctccgaata gccgaccgag
     5821 acgatccggt caccccggta ggtgaagctc gtcagtgagg ccagcgtgca ctgccgcttg
     5881 cgcgggtcgt gccacagcct gcggcgctcg acgaaggagc gcaggatcca gatcggcagc
     5941 tggtggctga cgcagaccgc ctcgtgcccg cgcgccgcgt cccgggcggc gtcgagcgcg
     6001 cccatcatcc ggacgacctg ctcgatgtac ggctcgcccc aggacggctt gaacggattg
     6061 gtgaggtgct tccagttgtc cggcttgcgc agcgcgccgt cgccgacgcc gaaggtcttg
     6121 ccctcgaaga cgttggccgc ctcgatcagc cggacgtcgg tggcgaggtc caggccgtgc
     6181 gccttggcga caggcgcggc cgtctcctgg gcacgctcca ggggggaggc gacgacatgg
     6241 gtgatgtcgc gcttctccag atgcccggcg acccggtcgg ccatctgccg gcccaggtcg
     6301 gagaggtggt agccggggcg gcgcccgtag agcacgccgt ccgggttgtg cacctcgccg
     6361 tgccggacca cgtgcaccac ggtcagctgc tcgtcgcggt tcacgtggcc gcggctcgcg
     6421 atgcctctcg cgtcctcgcc gttctcgccg ttctcaccgt tctcgccgtt cgtgacgtcg
     6481 ccgttcgtga tgtcgctcat gcggtggcct ccgccgcggc gcgggcggcg gcgggcaggg
     6541 cggcggcgat gcgctcgacc gcccgctcgt cgtgggccgt ggagacgaac caggactcga
     6601 acgccgaggg cggcaggtag acgccctgct ccagcatcgc gtggaagaac gcggtgaagc
     6661 ggaagacgtc ctgcttcttg gcgtcgtcgt agtcgcggac gggctcgtcg gtgaagaaga
     6721 cggagaacat gttgctcgcg gcggacacgg tgtgcgcgac gcccgccttg gtgagcgcgt
     6781 cgcccaccag ggagcgcagc tcggcggaga ccgcgtcgat cttcgcgtac gccgcgtcgt
     6841 ccagcagccg caactgggcg agcccggcgg cggtggcgac cgggttcccg gagagggtgc
     6901 ccgcctggta gaccgggccg gccggggcca ggtgcgccat cacgtcgccg cgaccgccga
     6961 aggccgcggc ggggaagccg ccgcccatca ccttgccgaa ggtcatcagg tcgggccgga
     7021 cgccgtcgac gccgtaccag ccggccttcg acgtacggaa gcccgtcatg acctcgtcgg
     7081 agatgtacag cgcgccgttc gccgcgcaca gctccttgag cccggcgttg aagccctccg
     7141 ccggcgggac gacgcccatg ttgccgggcg aggcctcggt gatcacgcag gcgatctcac
     7201 ccgggtgcgc ggcgaatgcg gcgcgcaccg cgtccaggtc gttgtacggc agcacgacgg
     7261 tgtccccggc cgtggcgccc gtgacccccg gcgtgtcggg cagcccgaag gtggccacgc
     7321 ccgacccggc ggcggcgagc agcgcgtcca cgtgcccgtg gtagcagccg gcgaacttca
     7381 cgaccttggc ccggcccgtg aaaccgcggg ccagccggat cgccgacatg gtcgcctcgg
     7441 tgccggagga gaccaggcgc acctgctcga cggggtcgat ccgcgccacg atttcctcgg
     7501 cgagcgcgac ctcgccctcc cccggcgtac cgaaggaggt gccccgggag accgcctcct
     7561 ggactgcggc gatgacctcg gggtgagagt ggccgagaat catcggcccc cacgagcaca
     7621 cgaggtcgac gtactcgcgg ccgtcggcgt cggtgaggta cggaccggtg ccggacacca
     7681 tgaaccgggg cgtaccgccc acggcccgga aggcacgcac gggagagttc acgccgccgg
     7741 gcgtcacgag ggacgcccgg tcgaacagcg actgcgaaac tggggcttcg tatgaatacg
     7801 ccactttggt cctgatctgc gattcgggta tcgggaggcc gggccgggaa atgcctatga
     7861 atctcggcca ccggtgagca gggagcgcgc tcccctcgta tcacgaaaga gcgtcagtcc
     7921 cctcgcgtct gcgaaactgg gccgacatag ggaaagctca cacatgccat ggtgtcagag
     7981 gcacgcgcgg tctttgcgga caggtgtttc accgcacgcc cgcgggggag gtcactgaca
     8041 cgatgatcgg gttgcgcggc gggggctgtg tctcctaaga agtagtcggg tggatgagat
     8101 atgcatcgcg gtggcggagt gggcgaaggg accgacgacc tggggcccga gcctgcccgg
     8161 cgagggcggc accggcgcag ggccgagcgc gcccagagca ggggcgcgga cagcacgccg
     8221 ccccccggga ccaggagcgg gggcgggatg ggggtgacgt acaaatactt cggcgccccg
     8281 gacggcgcca ccgccgcacg cgtgcccatc tcgatgcgcc cggaggagct cggcggtgac
     8341 gagctgggca tgggcggcat gttcaccaag atcaagccgg agaccgtggc cgccatggtc
     8401 ctgaccggaa tccagggcat acccctgcac aaggtccccc cgctcgaact tgtcgttctc
     8461 caccccgact acgcggtggt caagctcccg atgaccgtcg tcgacccgct gcgcggcgtc
     8521 ggtgaggagt ccgtcggcgc ggcggccttc atctggtcca cggtccccga ccgcggcggc
     8581 ccgcgcgacg ccttcaacgt ctaccaactg ctccacgagt ggcaggactt ctcccaccgc
     8641 ctgcacgacg cggggcatca ggcgtactgc ctggtgtggc cgtgacctgg ggtttccccg
     8701 gattcgggcg gggcttccgg gccccgctcc tgcagctcag cacagcgctc cgtcccctcg
     8761 ccccacgtgg cagccaccgt ccaggcttcg cgctcaccgc ggggacagag tcgttgatgg
     8821 cacgagactc ttccggatga cgctgtcggc agcacgcaga gctgctgaca gcgctccttg
     8881 catctggtcc gggagggcct ctgccccgag ggcgcaagcc cgcaccaggg tgcggcagtc
     8941 ctgctcctgc cggttcgtag caagctcgat gaacagagag ttcgccaagt tctcacgtgc
     9001 cgcgtagccg tcctcggcct ccgtcgccct ccggtgcaag tcctcggcga tgcggtacgc
     9061 ggtcggaaga tcgggggacc cgaccatgtc gaggacggtc aggcccagcc ggatatcgaa
     9121 gacggtcatc cccggctcgg ccttccgctc aaggtaggcg tctgccaagt ccgccaggtg
     9181 aacgccggct ggtcgtcccg cgtcgcggcg ccactgggcg gtcaggcatg ctgtgaccgt
     9241 ctgctcccac ggctcgccgg gcaccgtagc ggcgaggagc gtcgcggcgt gtgccgtgtc
     9301 tttcgcagcg agcgaggcga gtaccgctac ttgacgccca tcgagcattc gcctgcccac
     9361 acctcgatgg gtctccatgt gcgccagggc ctcggaccag cgtccctcgg cagtaagagc
     9421 gcgcgtccca tcggcgagca gcacacgcca cagccacgcc acgacttcat ggcggtcctt
     9481 gtctgtggcg gtgaggtccg ccggaatcgc aacgcctcca aatctggctg gtgtgcccgc
     9541 ctcgacagcc gcgtacaggt cgagcagccg ctgacgaccc gcatcggcgt gaccgccacg
     9601 gatctggagg cgggcgagat tgacgacggg ctccaagccg cgaatcgcgc tcattgcagg
     9661 cagggggcag gcatggagat acgcggcggc gtgctcgcgg cacatctcgc gcgcgaggtc
     9721 gggaaggccg agatcggagg caatgagcgc ggtctggttg tagacggagg acgccacccc
     9781 ctgatcggtc tccaccatcg cggtgtcggc caggtcgacg agcgcgcgca cgcgcttcgg
     9841 caggggaagg caggcgggcc ggaatcgggc gacgagcgga aagcgctgag ctgtggatcc
     9901 gtgcgggtcc atggactccc ccaggtatgt gtgaagacgg gtacggccac ggtggccgcc
     9961 ggtcgcacgc cggcggccac cgcccactac gcgtggggtg tcaactccag tcgacgatga
    10021 tgcggttcag cggggtgtca agcgcgaaga ggccggctcg ctgctcgatc gagggggcgt
    10081 cgagaggctg gatctcgaac gtggcttcac ggcctcggta ctccaggtcc cacgcgcgga
    10141 tggccgcagc gacccttgcg gccagttcat cgctgccggg gccgtggccg atgaccccga
    10201 actcccacag cttgccgccc tcggaggtct tcttctccga cagacgccgt gcgaggtagg
    10261 tgacggcgcc tttgtcgacg gttgcggtcg aggaggggta ggggtcctcg gtgagcaaag
    10321 tgcccttggc ggcttgcgga aagagcatcc ggatcaggcc ggagggaagg gagcaggtga
    10381 ggaacagttc catccactcc ggcgactcca tggcgcggac ggtcatgccc gtccactcct
    10441 cggtgcgcgg ctcgtgcagg acgccgtcga gggcctcggc gtcgattgtc tgcccggcgg
    10501 gggcctggag ccgtacggtt ccgtccgtgc tgagcgggat gacccggcgg tcgtcgtcgg
    10561 cgatgccccg cctgagcggc atgaaggtgt tcatctcgct accgagggac atccaccggc
    10621 catcgcgctg ctcataggcg atggagcggg acaccgtgcc cttgaggcgc tgcgggacga
    10681 gaagtcggcc cccgggagca agctgctgca accaggcgtg cggcacgccg tgcgcgccca
    10741 cggtggcaat gattcggtcg tacggcgcgc cttccgcgta gccgagggcc ccgtctcggg
    10801 tgaccgcctc aacgttggtg gttccggcgg cggacagatg cgcacgggcg ccctctacga
    10861 ggtcgtcgtc gacatcgagc gtggtgacgt gcccactctc accgaccaga tgggcgagca
    10921 gaccggcgtt gtaaccggtg cctgcgccaa gttcgaggac gcgctcgcct tgccgggcgt
    10981 cgagctggtc cagcatgagg gcgaccacgc ctggctggga ggcgcaggag atcgagctgc
    11041 cgtcggtgtc gtacttgatg tgcaccggcg cgttggcgta tgcgtcttcg agcggcacat
    11101 cgggcacgaa aacatgacgg ggcacggtcc gcaacgcgct ctccacggcg ggagtccggg
    11161 cgtttccgtc agcgcggagc tggtccacca ggacgttacg gaggcgctcg gcatcggacg
    11221 tcggggtggt gaccatgtcg gtgcccaccc tcttcacgct atcggcgttg gtcgtcggcc
    11281 cggtcggcga cgcggtgtgg tcactcgttc ccatgactgc ctctcgtgcg atgttgtaca
    11341 gagtgctctg gtcgtccctg agaagaccgg cgcggttggc gtggaagatg atgtggtggg
    11401 tgatgacggc tcgcaggccg cgtgtgagag cacccctttt gtcgaggcca gcgagggtgt
    11461 cccccgccct ctcgaaagcg gacacccatg ctccgtaccc atggagtggg ccgtcccgga
    11521 gggacaggcc gtgggcatca gcgctcatga gcttccgtac gaacgggatc agttcggcga
    11581 ctcgtgcatg tgacagagcg ctggtgaccg gccggagggt agcggccttc gcccatacgt
    11641 cgccctgctc gaaccagtcg agtccggcgc cgcgcatcat ggcgctcgcc agcaggaccg
    11701 tagtctccct gcgccccagg tggtccgggc tcggctggta ggtgagcagg tggcgggagt
    11761 cgctgtggaa cagtccatgg gcggtgtcca tggcgtccgg gccgccaaat gcctcggact
    11821 cgggttcgta gacagcgggc agccatgaca cgaccgcccc gtcacccacg agatcgctca
    11881 acagcgactc aatgatcggg gagggctcgt cggcgaggta ccgcagcggc cagggctgct
    11941 tgttcatgaa ccaccagccg gtgagctgcc ccgcggtctc ggctgtgatc agggcgggcc
    12001 cgaggcgttc gtcgatggtg tgccgggcgc tctcgcggtc gatgaaggtg atgttgtgct
    12061 gctgccagtc agggggcatc gaggtccttc ggtcggtgaa tcaagcaatg agcaggcagg
    12121 aatcccaggc ggactggggc ggtgcggcgg tatcggcagc gagaagagcc agtgctactc
    12181 cggcggctcc atcgagcagg ccgggccccg ctccggtgcc gctgacaagg gccgtggccg
    12241 cgcgttcgag gtccctgtcc accggacaga cagcggccag aagtcccggg atcgcggctc
    12301 ggagtcgacc ggcggttgaa gggtgggcgt ctgcggccgt gcggccggcg atgtgggcaa
    12361 ggccggcgaa gccgtggcac aggccgtggt ccgtcgtggc tccgagctgg tccgggtcgg
    12421 tgagagcggc ggcaagcacg ctttccgccg tgatctggcg ttcgatgtcg ctggtagcga
    12481 gcgcagcaag ttgctgggcg cgggcgaggc cggcggtgcc gtaacaccat gacggccgcc
    12541 ggagcttgga agcagcgcgg cgaccggtac gtagctcgct ccgggtaacc cagtacggcc
    12601 aggttgatcc tcggcctgtc tcctgctgcc agcagtcgag ccacgtcagg atggtgcgca
    12661 gcgctctgag gtgcccatcc gtgacggtgc ccttccgggc ggcgagggcc agaagggcga
    12721 gcactccggc gatgccgtgg gccgtgccgg tgttggcatg cccaccgggg aatcgttcgt
    12781 ccgggcttcc cgagggcccg gtcgcagtcc accaacccgg gaggtcctcg ccggcttgcc
    12841 tgatcggttc ggtgaggcgt acgcagtagt cgaggacagc gcgcaccaca gggctgcctg
    12901 agttccggcg cagaaggtag gcgccgtatc cggtcaggcc gcggatggtg tcgtactcgg
    12961 ccagctgcgg taggcatctg gaatcgatgc ggcgatgcgc tgcgtcgaga cggcgcctga
    13021 cgtcgatctc gatctgccgg tccatcgcgc ccaaggcgcg ttggtaggag tcaggaagat
    13081 ggtcggcggc gcaggcaagg gcgtgggcga aggcgggcac cccgtagaac gggtggctgt
    13141 caggtccgct cgtgaggaac ccgtgagacg cggcagcgag ccagccgtgc gcatgctgcc
    13201 acggtccgag gccgttcgcg gcccgttcga tgtggagaag cgcgattccg ggcgggccgt
    13261 aggcgagatg ttgccgacgt gtctgaagaa cggaaggcgc cgtgccgggg ttggcgagcc
    13321 gcgcagcaac ggcaccgacc aggccgagcg tcgggagcac ggtcacgccg acctcctgct
    13381 ggtgcgggca gtccacgcca gagcagcagc gcgcgccagg tagaggcaca cctcctcctc
    13441 ggggaagttc accgcgacgt gccgcacgaa gtggacgtgc agaagggagg ccaggacgtc
    13501 atcgacggcg atgccctggg cgtccgggcc gggaaggtgc agccggtacg cggcgagtgc
    13561 cgcatcgcgc tctgcccaac ccgacacgat ggcgtctcca ccctgcacct cgcgcagggc
    13621 ggcccagtcg tcggctgggt tcgcgagccg tacggcctcg ctgaattgcg ggcggggaac
    13681 ggacgcaggc gccgtaggcg agacgtggtc ggccagccag cgcatcgcgg cttcggcgct
    13741 gccgaggaac gcagaggcga tggcgacgga atgggccgcc accagtgcgc gttgcgccgg
    13801 tctctgtggc tctgcgagct gggcaaggac gctgcgcgag tctgcccgga acacctgctc
    13861 ggccgcctcc caagcggcgc cggagcccca acggcccatt tcccgatagg aggtggggta
    13921 gcgcagatct gccagtaggc cggcactgcg caggtcgtcg gcccacgcgc tcacggtgcg
    13981 cgccgtctga gcgaaggttc tgcggtcggg aagggcgata cgtacgcgga ggtgctgctc
    14041 cgggtcgcgg aagcggatga accaccatgg cgggttgccc agtcgttcga ggaggccggg
    14101 gaggtgctgg gagagcaagg tgtcctggcg gcgagggtct ccgtacaagg ctgcgagcag
    14161 caccgacgaa gcggcgggag tctgcagctg atccgacgag aggacgcgag cctgagtggg
    14221 aacgggcagg ggcggccagg acggcgatcg ggtcgctctg agcggcacca cgatctcgtg
    14281 ggctcgcccg ccgcaccagc cgtacgtttc tggttccggg gcctccatga gcacggcctg
    14341 gtgcgagcgg tcgaggtgtc ggagcaggag cgtccggtgg ccggcttcgt cgaggtcgag
    14401 gaagagacgt cggtcgtcct ccacgaggag cacgcggcga ggcgatcccc gctgcgcccg
    14461 ccattcggag agcgcggtgt cccactcagt acgagggcga gcacgaccgg gtaattcgga
    14521 cgcctccaga cgccagcgcg ccgggctcag caccgtacgc ccgtaccgca ggcgcggcag
    14581 gaacggcatc gctgctgcga cgccccagtc gaaggcggtg acctgcgcgc actgggcgcg
    14641 ggacacttcg gtgaggaacc gtgccaacgg cggagcgtgg gtgtgcaggt tcagcgcgtt
    14701 catgccgacg gcctccacgc ggtgcccccg ttccggagcg gccaggtaca tgcggcggcc
    14761 gtcgcacccc acggccaggt ccttcggggt gagaacggtg tctttcggcg cgcggtgctc
    14821 ctggagactg atcacggtag gcagcatctg cggggagcgg gtgacgtgag tgctctccgg
    14881 gagcagcggc gggaaggaga gctgggcggg cacggtatcg ctgtccgcgg ccggaagatc
    14941 ggccagctct gcggccaggg cctgacgcgc ggagggcgcc agtacgtcga ggaaccggcc
    15001 tgtcgagacg ccggccccgc gcgacacgct cacgacctcc agtcggaatc gtccgcgctg
    15061 caggtcctcc ggactggcgg cgtgcacgcg cacccccacc tccagatgcg gtggcagtcg
    15121 tggctcgtcg gggcccgcct ccaagaggtc gatctgttcg tcggtgagca cgacctcgtc
    15181 gcagccgtcg agcgcggcac cctgggccag gcgtacgagg gcgtcgtcgc gagcggagac
    15241 gcgaggccga cctggaccgg caggactgcc cgggtagccg tccgggtagc cggtcccgct
    15301 gtccgcgacg acctccgcga gagggaccat cgtgccgatg ccgtaccgct cgtagaagcg
    15361 ctggtggtag gcgttccact cggccgcccc gtacgggcgg gtgctcaccc gggtcaggac
    15421 gaaggcgacg cgttcgacct cccgggccac ttcctcgggt aggacgagcc gcgcatccaa
    15481 ccgcaggtca accgcggcag ggtgccgacg caggccgggc gcgagggccc gcatgcgcgc
    15541 tgcggtgctg tcccggccgc agcgcgtggc gtacgcctcc aagcccattc ggaccgcgtg
    15601 catctcacgt gccgtatccg ctaccgacgc aaggtcgtcg acgccgatcg cgtcgagttg
    15661 gccgagcagg tacccgaggg cgtcggtctc ggtgcttggc gcgtgcaggc tcgtgatgag
    15721 cactcgcctc cgtaccagct ccaccagtag acagtgcacc ttctccgtac cggcctcggg
    15781 gaactccgcc cggagctttt ccgtgagatc tccgcagcga atcggcgtcc gggcctcggc
    15841 gaggaccgca cgcaccggct ctgtcagggc cagggatgcc tcgaccgcgc gcatccggtc
    15901 gtcattggcg tcgggttgga acggcacgat gagccggtct ccccggctcg tcacggtgtt
    15961 gttgacgacg acgggaagtc ggtcgaggag ttccgggcag aactccagcc gttcgaccac
    16021 agcggcgagc cactcggccc ccgcacggcc gacggccacg tgctcctcgc cccaggccac
    16081 atgcacccga gggccgaacg ctgcagtggt cactccggcg aacaggccga agggtgtcgc
    16141 ccggtgctga gcccgcaaca gatagcgggc taccgacagc gccgcgcgcc gagcgtctcg
    16201 atggggagga ttctcggccg tacatacggc ccgcacctgc atggccaagg ctgggctgga
    16261 gtgctccacc gcgtcggcga tgtgctggtc cgcccaaacc gcgcgaagcc acgtcacgca
    16321 agcagaggag ccgtcggaag agtggtcatc cgggtcaggg cacggaggaa ccgacagaga
    16381 ccgtcgggcc acggcacgca cgagagcggt ggaaccggcg cggaaaactg cgggccgagc
    16441 aaccaccgat gacctccatg ggcgagggga tgggcggctg gtgccgccgc gcggagacgc
    16501 gacggcacca gaccgaaggt gacctggggt tcgagtcagg cgtcaggcga cattggtggt
    16561 gcaggcgccg caggtggaac cgcagttgtc gtcggtcagg ttgaccagac ctgccgggtc
    16621 agcgatctcc acgagcgaga catccaggtc gaagccgtct gatgcacccg gaatctgcgg
    16681 gcgtacttcg gtacggctgg gcactacggt gctgcgcgtc atgctgcact cctcttcatc
    16741 gttggttgtt gctgagctgg gctggaatgc ccaccaggag ccgccagagg agctatgccg
    16801 gacggctggc cctcggacca tctcctggcc gcccggcacg agggggcgcg gcccgcacag
    16861 aaagctctgg ccggaccgcc cgctcacgcc gggaagtcgt gtacgagggg ctgatcgagc
    16921 ggaggccgat caatgcccca tgaggtaggt gagggcctgt gccttgagac gatcaaggca
    16981 cagctcacat gcgtagaagg gggcgtactg cccgtcccac tgaaccgggc cgagccagat
    17041 cacccgcact ccggtccgtt cgcagccgag ccagcagtca ccggtgatcc atgatgaatt
    17101 catcgaggaa cggcccttcc cccagctggc cgagacggcc gatccggcag cctggtatct
    17161 ggcggtgccg gcccagagct gaaacggcgg acgggcaggg cccagaagaa gcgagggcat
    17221 cgcatccgag ctctcactcg tcgccctcgg tatggagttc ggcccagacc tctttgcccc
    17281 gcagacgtcc gcctgcactc tgaaggtcac agccccagcg gtcggccaca gcctctacga
    17341 ggaacagccc gcgacccgat tcgtcctcct cgcccgcgtg gctcagctcc ggcagacgcg
    17401 acggttcctc gtccacgatc ccgacgcgta cccgtgtcgc agttggccgc ccgacaacga
    17461 aacagacctc ggggcaaggg gtatgcctgg cggcattcgc gatcaactca gtgacgatca
    17521 gctcggcgcg gtcagcgagg acatcgaggt gccacatccc gagaaccccc cggacgagtc
    17581 tgcgtccggt ctcggccgtg gacggcacgc acgggaagac ttcgctgtag gtggggtggc
    17641 tggtgaggac cgtctcaact gtcttcttcg gaaccggcat gggatggagc cttcgtgtca
    17701 tctcggcgct cgctccaccc cttgtggctt ttcaggggcg gaccgagccg tcaacagccg
    17761 ctcgcgggaa gtggccgaca cccagataac tccgttgtcc ggggggctgg ttagggcgtt
    17821 caggtgctcg accgacgggc tcacctagga cgttttgacc tgctctttac ctggtgggca
    17881 gggagcgtgc gggctaccgt gcccgcatgg acgcgatccg caacaccgtc cttgaggcgt
    17941 ggatgatcga gcacggatac agctcaaaca gcctggccga cgccgtgaac agggctgttg
    18001 aaaagctgac gggacacgta ggcgggctcg acgggtcatc ggtccgggcg tggaaagcgg
    18061 gccgagtcac ctggccaaag tcagcaacac gtaccgcact tgaggtcgtc accggattac
    18121 ccgccgtcgc cttagggttc gtgccacggg gccggccttc gcccacccca gcgccatcgc
    18181 agcaggagga gcccgaaatg aagcgccgtg ccctcgtcgg cggcatcgca gctgcggctg
    18241 ccgcagcagc gtccccaggg accgcgtcac cgcgccgaat cggtatgagc gacgtcagcc
    18301 ggctgaacaa gcgcttcgct gagatcatcg ccagcgacca ccgccacggc gggcaacctg
    18361 gcatcgagga gcgggccgcc gcgctcgccg acgaggcgct caacctccag aacgcaggca
    18421 gtgccacgca gcgggttcgc agcagtctct acgcctccgg agcggcattc cgctcgtctg
    18481 cgatgtgggc cgccatcgac ggccggcgct acgacgtcgc gaaggcgcac atgcgcgagg
    18541 cccaagccct cgcggagatg tcgggggacc aggcaatcaa gttccgcatc tggagtcacg
    18601 cgggcaccat gtaccgccac atgggccgcc ccgccgacgc gtgcgctgcc aacgatgtcg
    18661 cccgcaatct gcacctcacc cgccgtgacc cgctgttcgc gtctctcggc ctggcccgcc
    18721 aaggcgccat ccacggtacg gcccagaacc ggaccgatac acgtcgcgcg ttcgagcagg
    18781 cgcaggacgc catgctgcgc gccgatccag ccgaccaccg gccggtctgg ttgctcgcct
    18841 tctacgacca ggccgaactg gactccttgg ccctctccgc gtacctggcg ctcggcgact
    18901 atccaaccgc cgagtaccac gcccaccgct gcctgtcctc gctccggcca cacatggcca
    18961 ggtcccgggc catcaccacg acccgtctcg cacacgccct actcgcccaa ggcgccgccg
    19021 aggccgcaac aaccaccgcg atgaaagtcc ccgtagacgc cgccacccgc cacgcccgcg
    19081 tgtcgcgcat gctccaagag ttcggggccg cgctccgcgc caccaccccg cgcagcacca
    19141 ccgtccagaa ttggaccgag cacaccacca cctggaagac ggccgcatga ccacggcact
    19201 cgcccccgag ctgcgcactt tcaccaacct ggacaccgct cgcggcgacc tcctcgacgt
    19261 gtacgccgag gtacgcgccc cgctgctgca cctgccgaac tacgcggtga ccgcgttcgg
    19321 cgaacgcatc gaccggcatt ccacagaacc aggctttacg gctgtcctcg catacgcggc
    19381 cggccaaccg gtcggctacg cgtacagcaa caccatcgag cacggggacc gctactggca
    19441 gcgcaccagc ccgacgccgg cggagaagta cacgaagcgc ccggccgcgg ctttgaagga
    19501 gatcggcgtg cacccggcct ggcgcaagac cggcacggcc cgccgcatcc acgacgccct
    19561 cctcgccaca cgtgacgagc cgcacgtcac gctcatggtc aactcggccg ctggggacgg
    19621 aaaggtccac tcgctctaca agtcgtgggg gtacgaggac atagggcaga gccagccgtc
    19681 accagcctca cctgtgctta ccgtcatgat ccacaccaac cgttgaccac cacggaggtt
    19741 gggaatggcg gagcaggtgc gtgtacgcgc gcagcgtgaa gccggggccg gagtggccca
    19801 gagagcgcct tgcacctcag cagcccacgg cgcgttggcg atcgaaagta aagaggagag
    19861 cgatgtcctc cctccgcgtt cgagcttgcg gaccacaccg acggacacag cggcggcctc
    19921 ggctaactgc tcctgggtca tggcgccgcg gagcgccttc atgcgctccg cggtggtgta
    19981 ctcagaccac tgcatgatct agaacctccg cgtaatgggc tccacacgga cagtactggg
    20041 tgagcagtgg tgccgacagg ttttggctgg actgcagttg ggcttacgtg acggacgccg
    20101 ccgtcaagcc gagaagtgcc tccagctcgg ccaccgcggt gtcctcgtcc gtcgcgtgga
    20161 cggtggcgat gcccagctcg gcggccggcg ggaggttgat cgcgtgatca tccacgaaaa
    20221 cgcaccgctc ggccgggagg ccgatgagat cgagggcgag ctgatagatg gacgggtcgg
    20281 gcttggccag ccctaccagc tcggacacga cgtgtacgtc gaacacgtcc cagacgccga
    20341 catgttcgta cgggttgaat gggtcgaggc cgaagctgtt ggacagcaat gcgagccgat
    20401 ggccggccgc acgcgcggag cgggcgagcg cgtccatccg gcgagagacg ggcacctccg
    20461 cccaggcccg ccccatcagg ttcaccggat ccacgtgctc cccgagaaga gcggccgtgc
    20521 cctggttcca ctcggtctgc cctatctcgc cgatctccaa cgccgtgtag aggcggcgcc
    20581 cttcggggtg atcgttgagg gtgctgcgcc acgccccggg cgccagccct tcggatacgc
    20641 accaggcgcg gtggacgtcg accgggctgg cggtgagcac tccggcgaag tcgaggatca
    20701 ggccacgctc ctcacgcccg ctggcgaccc ctctgctgtg cgacatccgg cgattctccc
    20761 cttccgcagg tggtctccaa gggacgctac cgcgcggcgt tgcggccgcg tgcagagccc
    20821 accactgtca ccgctcccgg gtagtcagca gagtgtgttc acgctccagt ccttgctctc
    20881 attcgatgcg ctgcgtccag tgcaccgagc caggatcgct ggcgctgtcg cacgcacgcc
    20941 gcgttcggcc cctctacgag gcccgcgccc cgccgggccc caccaccacc ggcagcctca
    21001 gctccggaca gccccggccg ccccggccgt ccccgtcgcc ccagtcaccc cgccggcccc
    21061 tcccggacgc caccccggat cgcgccccgt caccgccagc aggcgctcga aagcggtagc
    21121 cccctcctcc accgggaacg gctcaccgaa caccttcatc tcccgggcct gcggagccag
    21181 cgccgccagc cccggcccca gttcgtcgag cacgcgctcc tccggcacga agtccgcgcc
    21241 cgtcgcccgc gccaggtccc aggcgtgcac ggtcaggtcg ccgagcacca tgagccccac
    21301 cgtccgggcc ggcagcccca tctgcccggt cgtgccctcc tcgacgcccg gcacgctcca
    21361 cgcctccacc agccgggccg tctcggcacc gaacctggcc cgccagtcac ccgccacgaa
    21421 ctccggcacc tggccgaaat ccaccttctc gcgggccgcg agggcctgga agttcaccac
    21481 cacctggaac aggtggttca ccagcgcccg cacgtcgtac tcggcgcagg gcgtaccacc
    21541 gcccagctgc ccgtcgtcga tcccccgcac gacgggcagg gcccggtccg cggcggcttc
    21601 cagcagttca ccgatcgtct gtgtcatgcc tccaccctgc gcccgcgcac cgcccgacgt
    21661 cttgaagaaa cacgacacac gacaggcgtg tggaggacgc gggactaaaa tcaggccatg
    21721 gccgcaggac cccgccgcga cacccggggc atcgtcgacg ccccggacct gttcgcgcac
    21781 gtgcgcttcc gccgccgcga gcccgccgcc gggctgcgcc cgtatctgga gcactactgg
    21841 ctgatcgact gggacctcac cgagccgtac gccgcccatg tcgtcccgca tccgtcggtg
    21901 aacctggtct tccagcggta cgaggccggg gacggcgccc gggagcggtc cgggtacgcc
    21961 gaggtcgcgg gcgtcgaccc cgggctgttc gcccggaagc tggccgggcg cggccgggtc
    22021 tgcggggtgc agttccggcc cggcgggttc cgcccgttcg cacccgggca cccggtgtcc
    22081 gcgtggaccg ggctgcggtc cgacgccgcc ggggcgctac ggctgccgcc gcctgtccgg
    22141 gccgtcctgg acccggacga cgaggacgcg cgggtcgcgg cgctggacgc cttcctgctg
    22201 gccctggagc cccgccccga tcctcgggcg acgctggcca tggccgtcgt cgaccgggtg
    22261 cgcacggacc gcacggtgct ccgggccgac catctcgccc gggacgcggg gctctccgcc
    22321 cgcgccctgc aacggctctt cgccgcgtat gtcggcgtcg gccccaagtg ggtcatcctc
    22381 cgctaccgcg tccacgaggc gctggaacgc gccgggtccg acccggccgt cgactgggcg
    22441 cggctcgcgg cggacctcgg ctacagcgac caggcccatc tggtgcggga cttcaccgcg
    22501 acggtgggcg tgcccccgac cgcgtacgct ccgcgctgac ggcgcgcggg cgtccgcacg
    22561 ccccgcgcga agcccggagc atcccccgta cacctcgcac gccccgtatg ccccgtgcac
    22621 ctcgtgcccg acagccccca cagccctcgc ggcccccgcc tgccccgcag ccccgccgga
    22681 ccccgccaaa tccctggcag gccgtcccgc cccggtggca tcctgaccgg gtgaacggac
    22741 ccgagatcac tctcgaagta gcccctgagc tgcgactctt cgccccgcac gaccgccgcg
    22801 gcgggcccac acccctcgtc acggacggct cctcgaccct cggccatgtc atcgagtccc
    22861 tcggcgtccc gctcaccgaa gccggaacgc tcctggtgaa cggcgccccg gtggcccgct
    22921 cgcatgtgcc cggccccggc gagcacgtcg acgtacgcgc agtggaacgc ccccagcagg
    22981 tccccggcgc acccctgcgc ttcctgctcg acgtccatct cggcacgctg gcccgccggt
    23041 tgcggctcct gggcgtcgac gcggcgtacg agagcgagga catcggcgac cccgccctgg
    23101 ccgccctctc cgcacgggag cggcgggtcc tgctctcccg ggaccgcggg ctgctgcgcc
    23161 gccgcgagat ctgggccggg gcgtacgtct acagcgaccg ccccccggag cagctccgcg
    23221 acgtcctcgg ccgcttcgct ccggccctgg ccccgtggac ccgctgcacc gcgtgcaacg
    23281 gcacgctggc cggggcggcg aaggactccg tgagcggact gctcgaacac ggcacccagg
    23341 aggcgtacga cgtgttcgcc cagtgcaccg cgtgctcccg ggtgtactgg cgcggcgccc
    23401 atcacggcca cctggagacg atcgtttccg aggcgatggc cgagttcggg ggcgcgccgg
    23461 cctgagagct ttcccgcgcg gccttcccgc acagctctcc cgcaggggct tcccgcacgg
    23521 cttcccgcag cggcttccgg acggatcgtg ccgaccgggc gcgtgagccg cgggcctcgc
    23581 gcgctctgcc ggtcgtgccc tcccgcgcac ggggtgcgcc gcgccgcctg cctatccttc
    23641 tccccgtacc cgatgagcag tccgagggag atcgtcatgg ccgccacccc catcgccgtc
    23701 gtcaccggcg cgagcagcgg catcggcgcc gccaccgccc gtacgctggc cgccgcgggc
    23761 ttccgggtcg tgctgaccgc ccgccgcaag gaccgcgtcg aggcgctggc cgccgagatc
    23821 accgaggccg gtcaccaggc gacggcctac cccctggacg tcaccgaccg cgcggcggtc
    23881 gacgagttcg ccaccgcgtt ccgctccctc gccgtcctcg tcaacaacgc gggcggggcg
    23941 ctcggggccg accccgtcgc gaccggcgac cccgccgact ggcgccagat gtacgagacc
    24001 aacgtgatcg gcacgctcaa cgtcacccag gccctgctgc ccgccctcac cgcgagcggc
    24061 gacggcacga tcgtgatcct ctcctccacc gcggcgctgt ccgcgtacga gggcggcggc
    24121 ggttacgtgg cggccaagca cggcgagcac gtcctggccg agaccctgcg gctggagatc
    24181 gtcggcaccc cggtccgcgt catcgaggtg gcccccggca tggtcaggac cgaggagttc
    24241 gccaccaccc gcttccgcgg cgacacggag aaggccgcca aggtctacgc gggcgtcgac
    24301 gcaccgctca ccgccgagga cgtggccgac acgatcggct gggccgtcac ccgccccagc
    24361 cacgtcaaca tcgacctcct ggtggtccgc ccccgcgccc aggcctccaa cacgaaggtc
    24421 caccgcaccg ggtgaagccg aatcgcccct tcgggggcgg ggtgacgccc cgctcggcga
    24481 cgagcaccgg gggggggcgt gcggggtggt cgtgcggggt gatcgcgcag cgcgctccgg
    24541 gcgtcagcgc cgccacctcc cagctgggca ggtcggcctc gcgggcggtt ccgtagtccg
    24601 tggtgaggcg cagccgggtc gtgaggccga ggaaggtcgc cacccgtaca gagccggcgc
    24661 gggagcctcc cgccggccgg cgcgcgccgg gcgcccccgg cgcgcgggcc ctcgtcccgg
    24721 gcgcccccgg ccgcgtcgtg ttaggaagga agcgcccccg gccgccgtac cggccgaaag
    24781 cccacgaggg agcggtgcgc gatgaagctg gtggtgcagg agttcctgac gctcgacggc
    24841 gtctcccagg gccccgggtc ccccgacgag gacaccagcg acgggttcac ccggggcggc
    24901 tggttcgtgc cgcatttgga cgaggagttc gagcggcagg cgggcgagtg gctcggcgag
    24961 gcggacgcct tcctgttcgg ccggcgcacc tacgagaact tcgcccggga ctggccgcgc
    25021 atgaccgacc accccttcgc cggcatcctg aacggcctgc cgaagtacgt ggcctcgaac
    25081 acgctgaccg aggccacgtg ggacccgacc acaatcctct ccggcgacat ccccgcccag
    25141 gtggccgagg tgaagcggcg ccccggccgg gacctccaga tccacggcag cgcccgcctg
    25201 gcgcagtcgc tgctggccgc gggcctggtc gacgaactgc gcctggccat cgccccggtc
    25261 gtggtgggcg agggccgcag actgttcccg gacggcggcg ccccggccgg cctgcggctc
    25321 ctcagccacc ggacgacccc ggccggggtc tccgtacacg tcttcacggc cacgggacca
    25381 ccggactacg cgacgtacgg gggcggggcg tagccggact cagcccttca cgcacaccag
    25441 ctgcttgagc ttcgcgacga cctggaccag gtcccgctgc tgatcgatga cctgctcgat
    25501 cggcttgtac gctccgggga tctcgtccac gacaccggag tccttacggc actccacgcc
    25561 ctgcgtctgc tcctccaggt ccttggtgga gaagcgcttc ttcgccgcgt tccggctcat
    25621 ccggcgcccc gcgccgtgcg acgccgagtt gaaggacttc tcgttgccga ggcccttcac
    25681 gatgtacgaa ccggtgccca tggaccccgg gatgatcccg aagtcgccgg accccgcccg
    25741 gatcgcgccc ttgcgggtga ccagcaggtc catgccctcg taccgctcct ccgccacgta
    25801 gttgtggtgg caggagatga cctgctcgaa ggtgacccgg gccttcttga actccttgcg
    25861 gaccacgtcc tggaagagtc ccatcatgat cgcccggttg aacttcgcgt actcctgcgc
    25921 ccagaagagg tcgttgcggt acgcggccat ctgcggggtg tccgcgatga agaccgccag
    25981 gtcgcggtcg atcaggccct ggttgtgcgg cagcttctgt gcctggccga tgtggaagtc
    26041 ggccagctcc ttgccgatgt tccgcgagcc ggagtgcagc atcaaccaga caaaaccggt
    26101 ctcatcgaga cagaactcga tgaaatgatt acctgatccg agcgttccca tctgcttcgt
    26161 ggcacgctcc tgacggaatt tgaccgcatc ggcgatcccc ccgaaccgcc cccagaagtc
    26221 gtcccatccc gacgtcggga acccgtgcag cttccccggg tccaccacgt cgtcgtgcat
    26281 cccccggccg accggaatgg cctgctcgat cttggaa
//
