GCF_028554415.1 - 18 region(s)

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Location: 426,388 - 485,172 nt. (total: 58,785 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

L3476_RS02205: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

L3476_RS02105: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: ligase synthase

L3476_RS02180: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS02185: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

L3476_RS02190: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

L3476_RS02195: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

L3476_RS02200: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.85	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.79	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.79	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.77	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.75	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.01 out of 27.78

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.13 out of 18.57

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.72 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.13 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19

Confidence: medium

Additional weak hits (15):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.00 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.98 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.64 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.53 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.30 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.28 out of 39.62

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.00 out of 29.25

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.17 out of 20.01

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.23 out of 20.01

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.44 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.26 out of 31.73

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.24 out of 20.01

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.20 out of 29.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 426387 - 485172:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk) + (X - X) + (mal) + (NMe-Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS02180: NH2

CAL_domain (147..466): NH2

minowa: NH2

Prediction, score:

NH2: 125.8
Acetyl-CoA: 48.2
fatty_acid: 28.0
AHBA: 14.4
shikimic_acid: 10.7

L3476_RS02185: pk

PKS_AT (613..906): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 70.8%; Methoxymalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 124.1
Methoxymalonyl-CoA: 118.8
Malonyl-CoA: 116.3
Isobutyryl-CoA: 82.6
Ethylmalonyl-CoA: 82.2
Propionyl-CoA: 77.1
2-Methylbutyryl-CoA: 59.1
trans-1,2-CPDA: 52.9
3-Methylbutyryl-CoA: 51.9
inactive: 40.8
CHC-CoA: 38.9
Acetyl-CoA: 37.3
Benzoyl-CoA: 29.6
fatty_acid: 23.2

L3476_RS02190: X - X

AMP-binding (501..893): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MAQAFDAWVFEMVLISAGEYNAYGPSEATVWVTV
Nearest Stachelhaus code(s):: Phe DAFTVAAVWK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1560..1979): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FWQSHDPLLRDVHVFFGGDLNGYGATETQIMGIY
Nearest Stachelhaus code(s):: Htia DPHHFGLIGK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

L3476_RS02195: mal

PKS_AT (530..820): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 139.1
inactive: 97.7
Methoxymalonyl-CoA: 53.6
Methylmalonyl-CoA: 44.8
Propionyl-CoA: 28.0
2-Methylbutyryl-CoA: 16.5
Ethylmalonyl-CoA: 14.9
CHC-CoA: 10.5
fatty_acid: 8.4
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

L3476_RS02200: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (507..921): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQIFGGEINMYGITEITVHATF
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 2 - terpene-precursor

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Location: 653,070 - 673,945 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

L3476_RS02985: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

L3476_RS03025: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

L3476_RS03035: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001594.3	0.37	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000635.3	0.36	terpene	carotenoid	Paracoccus sp. N81106
BGC0000666.5	0.36	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001594.3	0.37	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000635.3	0.36	terpene	carotenoid	Paracoccus sp. N81106
BGC0000666.5	0.36	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

L3476_RS03025: PT_FPPS_like

Domain 1 (25 - 289): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

Additional weak hits (8):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.82 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.38 out of 21.55

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.80 out of 30.11

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.15 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.39 out of 33.14

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.00 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.36 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_CP094446.1 - Region 3 - NRPS

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Location: 1,186,722 - 1,240,101 nt. (total: 53,380 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

L3476_RS05795: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: acetyltransferase

L3476_RS05725: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

L3476_RS05680: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase

L3476_RS05720: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.19 out of 30.22

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.45 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.13 out of 24.78

Confidence: medium

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.86 out of 26.12

Confidence: medium

Additional weak hits (12):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.59 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.31 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.33 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.15 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.59 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.44 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.05 out of 27.18

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 22.61 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 1186721 - 1240101:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS05720: X - X - X - X

AMP-binding (444..853): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LLFAFDASCWEKLLITGGSFNAYGPTEDSIVTTI
Nearest Stachelhaus code(s):: Leu DAWIIGAIVK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1496..1912): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LLFAFDASCWEKLLITGGSFNAYGPTEDSIVTTI
Nearest Stachelhaus code(s):: Leu DAWIIGAIVK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2555..2971): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LLFAFDASCWEKLLITGGSFNAYGPTEDSIVTTI
Nearest Stachelhaus code(s):: Leu DAWIIGAIVK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (3619..4030): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LLFAFDASCWEKLLITGGSFNAYGPTEDSIVTTI
Nearest Stachelhaus code(s):: Leu DAWIIGAIVK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ClgR	Caseinolytic protease gene regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
LuxO	Repressor of luminescence
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 4 - RiPP-like,azole-containing-RiPP

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Location: 1,414,239 - 1,437,824 nt. (total: 23,586 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

L3476_RS06755: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000600.3	0.23	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002667.2	0.23	ribosomal	estericin A	Clostridium estertheticum
BGC0001145.5	0.22	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.22	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000043.5	0.21	PKS	curacin A	Moorea producens 19L
BGC0000550.3	0.20	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000547.5	0.20	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000613.5	0.20	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0000557.5	0.20	ribosomal	streptococcin A-FF22	Streptococcus pyogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002667.2	0.44	ribosomal	estericin A	Clostridium estertheticum
BGC0001173.5	0.43	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000600.3	0.43	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002700.2	0.42	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000188.5	0.41	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001747.3	0.41	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000616.4	0.41	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000550.3	0.41	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.78 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.90 out of 21.55

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

Additional weak hits (11):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.78 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.04 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 28.36 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.90 out of 36.54

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.69 out of 21.55

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.17 out of 32.93

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.24 out of 29.65

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.61 out of 26.85

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 1 - 95; Score: 159.1; RRE type: Thiopeptide_F_RRE; Location: 4 - 86; Score: 44.0
: RRE type: Heterocycloanthracin_C_RRE; Location: 1 - 95; Score: 159.1; RRE type: Thiopeptide_F_RRE; Location: 4 - 86; Score: 44.0

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

Core peptide predictions

No core peptides found.

NZ_CP094446.1 - Region 5 - NRPS

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Location: 1,710,887 - 1,763,741 nt. (total: 52,855 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

L3476_RS07960: hydrolase

smcogs: SMCOG1179: hydrolase

Lyases: decarboxylase

L3476_RS08075: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

L3476_RS08030: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS08040: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS08045: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0000307.4	0.67	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0000307.4	0.67	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.33 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.65 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.42 out of 20.97

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.76 out of 24.78

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.68 out of 19.52

Confidence: medium

Additional weak hits (6):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.50 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.64 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.35 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.40 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 1710886 - 1763741:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Val) + (Ile)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS08030: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (27..420): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNCGFDASTFEGFLLVGGEMNVYGPTENTTFSTA
Nearest Stachelhaus code(s):: Ile DAFFLGVTFK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS08040: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (824..1232): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTGFDASTFEGWLIVGGELNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS08045: X

AMP-binding (266..675): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LYLAFDASVYEGMLVSAGELNAYGPTEVTIICSV
Nearest Stachelhaus code(s):: Phe DAWTVAAICK (65% 8Å match); Ph-Ser or Phe DAFTVAAIWK (62% 8Å match); Val DAWMFAAILK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_CP094446.1 - Region 6 - lanthipeptide-class-iii

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Location: 1,829,845 - 1,852,451 nt. (total: 22,607 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

L3476_RS08465: methyltransferase

smcogs: SMCOG1248: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002701.2	0.84	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0002700.2	0.68	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.64	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5	0.53	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.53	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.49	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002150.2	0.43	ribosomal	triculamin	Streptomyces triculaminicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002701.2	0.84	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0002700.2	0.68	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.64	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5	0.53	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.53	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.49	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002150.2	0.43	ribosomal	triculamin	Streptomyces triculaminicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for L3476_RS08495

L3476_RS08470

Leader:

MNAVLELQKLAQATDGKGQAAE

L3476_RS08475

Leader:

MNAVLELQKLAQATDGKGQAAE

L3476_RS08480

Leader:

MNAVLELQKLAQATDGKGQAAE

Shared core:

ATITIITVGKSTLSVYKCN

Core with dehydrations:

ADhbIDhbIIDhbVGKDhaDhbLDhaVYKCysN

antiSMASH-DB 4.0 matches for L3476_RS08470

100.0%

NZ_CP041405.1and 4 others:

NZ_CP041405.1 Lanthipeptides: FLT43_RS29605_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08480_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08475_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08470_lanthipeptide

Lanthipeptides: FLT43_RS29610_lanthipeptide

1

ATITIITVGKSTLSVYKCN

19

ATITIITVGKSTLSVYKCN

1

ATITIITVGKSTLSVYKCN

19

89.5%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: L3476_RS08485_lanthipeptide

Lanthipeptides: FLT43_RS29600_lanthipeptide

2

TITIITVGKSTLSVYKCN

19

TITIIT+GKSTLSVYKCN

2

TITIITIGKSTLSVYKCN

19

85.0%

Lanthipeptides: FLT43_RS29615_lanthipeptide

1

ATITIITVGKSTLSVYKCN

19

ATITIIT+GKSTLSVY+CN

1

ATITIITIGKSTLSVYQCN

19

with 16 more sequence matches

Only the first 10 are displayed here.

57.9%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: L3476_RS08510_lanthipeptide

Lanthipeptides: FLT43_RS29580_lanthipeptide

4

TIITVGKSTLSVYKC

18

TIIT+ S LSVYKC

5

TIITIC-SVLSVYKC

18

36.8%

NC_015434.1and 117 others:

NC_018750.1 Lanthipeptides: SVEN_RS32110_lanthipeptideNC_018750.1 Lanthipeptides: SVEN_RS32110_lanthipeptideNZ_BBNO01000003.1 Lanthipeptides: TU31_RS37940_lanthipeptideNZ_BMSV01000002.1 Lanthipeptides: IE106_RS06150_lanthipeptideNZ_BMTO01000007.1 Lanthipeptides: IE136_RS15615_lanthipeptideNZ_BMTP01000009.1 Lanthipeptides: IE109_RS18470_lanthipeptideNZ_BMTU01000009.1 Lanthipeptides: IE118_RS22890_lanthipeptideNZ_BMUN01000001.1 Lanthipeptides: IE238_RS00740_lanthipeptideNZ_CP007699.2 Lanthipeptides: T261_RS39185_lanthipeptideNZ_CP009754.1 Lanthipeptides: NI25_RS05015_lanthipeptideNZ_CP015866.1 Lanthipeptides: Spa2297_RS27800_lanthipeptideNZ_CP017157.1 Lanthipeptides: SL103_RS15895_lanthipeptideNZ_CP019457.1 Lanthipeptides: BXT88_RS03410_lanthipeptideNZ_CP019724.1 Lanthipeptides: B1H29_RS35355_lanthipeptideNZ_CP019779.1 Lanthipeptides: STRMOE7_RS03775_lanthipeptideNZ_CP020042.1 Lanthipeptides: B4U46_RS32710_lanthipeptideNZ_CP023202.1 Lanthipeptides: SXIN_RS23100_lanthipeptideNZ_CP023691.1 Lanthipeptides: CP981_RS03050_lanthipeptideNZ_CP023692.1 Lanthipeptides: CP980_RS04735_lanthipeptideNZ_CP023700.1 Lanthipeptides: CP969_RS04700_lanthipeptideNZ_CP027299.1 Lanthipeptides: C1N79_RS34970_lanthipeptideNZ_CP028158.1 Lanthipeptides: C6361_RS04660_lanthipeptideNZ_CP028159.1 Lanthipeptides: C6W10_RS01185_lanthipeptideNZ_CP029042.1 Lanthipeptides: DDE74_RS03525_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029541.1 Lanthipeptides: DKG71_RS05245_lanthipeptideNZ_CP034279.1 Lanthipeptides: EIZ62_RS28660_lanthipeptideNZ_CP034353.1 Lanthipeptides: D1J63_RS04900_lanthipeptideNZ_CP039123.1 Lanthipeptides: E5N77_RS35250_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS09720_lanthipeptideNZ_CP045309.1 Lanthipeptides: GCE86_RS12520_lanthipeptideNZ_CP046104.1 Lanthipeptides: GKC29_RS19975_lanthipeptideNZ_CP046905.1 Lanthipeptides: GPZ77_RS32930_lanthipeptideNZ_CP047140.1 Lanthipeptides: GLX30_RS11420_lanthipeptideNZ_CP050976.1 Lanthipeptides: HEP86_RS04470_lanthipeptideNZ_CP054920.1 Lanthipeptides: HUT15_RS04615_lanthipeptideNZ_CP059322.1 Lanthipeptides: H1D33_RS20095_lanthipeptideNZ_CP059322.1 Lanthipeptides: H1D33_RS20090_lanthipeptideNZ_CP060825.1 Lanthipeptides: IAG43_RS32355_lanthipeptideNZ_CP074111.1 Lanthipeptides: KE639_RS31630_lanthipeptideNZ_CP084681.1 Lanthipeptides: KI385_RS00885_lanthipeptideNZ_CP085300.1 Lanthipeptides: LJA35_RS05220_lanthipeptideNZ_CP086217.1 Lanthipeptides: LJ741_RS03435_lanthipeptideNZ_CP092183.1 Lanthipeptides: COUCH_RS09775_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS09690_lanthipeptideNZ_CP098437.1 Lanthipeptides: NCG97_RS34740_lanthipeptideNZ_CP099468.1 Lanthipeptides: NFX46_RS16770_lanthipeptideNZ_CP101137.1 Lanthipeptides: M6G08_RS24535_lanthipeptideNZ_CP102332.1 Lanthipeptides: NRO40_RS01140_lanthipeptideNZ_CP102609.1 Lanthipeptides: NUT86_RS03980_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33560_lanthipeptideNZ_CP114202.1 Lanthipeptides: STRLI_RS35870_lanthipeptideNZ_CP114203.1 Lanthipeptides: STRNI_RS37360_lanthipeptideNZ_CP114205.1 Lanthipeptides: STRTU_RS33380_lanthipeptideNZ_FMCR01000005.1 Lanthipeptides: GA0070561_RS23835_lanthipeptideNZ_FMCS01000001.1 Lanthipeptides: GA0070214_RS02345_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07020_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07015_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07010_lanthipeptideNZ_FMDM01000002.1 Lanthipeptides: GA0070213_RS04970_lanthipeptideNZ_FNHI01000003.1 Lanthipeptides: BLT82_RS06465_lanthipeptideNZ_HF570108.1 Lanthipeptides: MILUP08_RS22425_lanthipeptideNZ_JACHJE010000006.1 Lanthipeptides: FHS32_RS15850_lanthipeptideNZ_JACHJI010000005.1 Lanthipeptides: FHS37_RS15430_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACWAA010000001.1 Lanthipeptides: ICA23_RS00800_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09870_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09875_lanthipeptideNZ_JAFEJA010000002.1 Lanthipeptides: JE024_RS34830_lanthipeptideNZ_JAFEUO010000005.1 Lanthipeptides: JQN84_RS18770_lanthipeptideNZ_JAFEUO010000005.1 Lanthipeptides: JQN84_RS18765_lanthipeptideNZ_JAGFWR010000037.1 Lanthipeptides: JQN83_RS31375_lanthipeptideNZ_JAGFWR010000037.1 Lanthipeptides: JQN83_RS31370_lanthipeptideNZ_JAGGOI010000031.1 Lanthipeptides: J7E87_RS22160_lanthipeptideNZ_JAGPXN010000015.1 Lanthipeptides: KBX06_RS19685_lanthipeptideNZ_JAGPXN010000015.1 Lanthipeptides: KBX06_RS19680_lanthipeptideNZ_JAGPXW010000002.1 Lanthipeptides: KBX71_RS04195_lanthipeptideNZ_JAGPXX010000007.1 Lanthipeptides: KBZ10_RS10785_lanthipeptideNZ_JAGPYC010000033.1 Lanthipeptides: KBZ00_RS31440_lanthipeptideNZ_JAHLXF010000022.1 Lanthipeptides: KQY13_RS30555_lanthipeptideNZ_JAIHBQ010000001.1 Lanthipeptides: K4902_RS04515_lanthipeptideNZ_JAJJMU010000026.1 Lanthipeptides: LOC25_RS31275_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAPKNL010000004.1 Lanthipeptides: OSI21_RS07750_lanthipeptideNZ_JAPNLM010000003.1 Lanthipeptides: OTB16_RS07305_lanthipeptideNZ_JH993790.1 Lanthipeptides: STRVIR_RS0131905_lanthipeptideNZ_KN039948.1 Lanthipeptides: FM21_RS29525_lanthipeptideNZ_LIPF01000004.1 Lanthipeptides: AMK11_RS16660_lanthipeptideNZ_LIVQ01000005.1 Lanthipeptides: AMK16_RS35205_lanthipeptideNZ_LIVQ01000005.1 Lanthipeptides: AMK16_RS35205_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVX01000004.1 Lanthipeptides: AMK29_RS15650_lanthipeptideNZ_LIWB01000010.1 Lanthipeptides: AMK33_RS24360_lanthipeptideNZ_LIYH01000004.1 Lanthipeptides: AMK26_RS17765_lanthipeptideNZ_LT607409.1 Lanthipeptides: GA0070612_RS21605_lanthipeptideNZ_LT607733.1 Lanthipeptides: GA0070610_RS13855_lanthipeptideNZ_LT607733.1 Lanthipeptides: GA0070610_RS13850_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04340_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04335_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04330_lanthipeptideNZ_MPOH02000012.1 Lanthipeptides: BM536_RS17150_lanthipeptideNZ_NBCN01000003.1 Lanthipeptides: BKD26_RS06570_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_QGGR01000008.1 Lanthipeptides: BC793_RS19230_lanthipeptideNZ_RAIF01000032.1 Lanthipeptides: EBH09_RS35480_lanthipeptideNZ_RBAK01000011.1 Lanthipeptides: D7223_RS24620_lanthipeptideNZ_SOPG01000008.1 Lanthipeptides: E0I08_RS17090_lanthipeptide

Lanthipeptides: VAB18032_RS17930_lanthipeptide

4

TIITVGKSTLSVYKCN

19

+++ G S+LSV CN

2

SLLLCGDSSLSVTTCN

17

36.8%

NZ_BBOL01000008.1and 7 others:

NZ_BBOL01000008.1 Lanthipeptides: LPU61_RS25375_lanthipeptideNZ_CP058322.1 Lanthipeptides: HXZ27_RS14120_lanthipeptideNZ_CP058322.1 Lanthipeptides: HXZ27_RS14115_lanthipeptideNZ_FMCT01000009.1 Lanthipeptides: GA0070563_RS21095_lanthipeptideNZ_FMCT01000009.1 Lanthipeptides: GA0070563_RS21090_lanthipeptideNZ_FMCW01000007.1 Lanthipeptides: GA0070558_RS08825_lanthipeptideNZ_FMCW01000007.1 Lanthipeptides: GA0070558_RS08820_lanthipeptide

Lanthipeptides: LPU61_RS25380_lanthipeptide

4

TIITVGKSTLSVYKCN

19

+++ G S LSV CN

2

SLLLCGDSGLSVTTCN

17

35.0%

NZ_CP077658.1and 1 other:

NZ_JACHJG010000001.1 Lanthipeptides: FHS38_RS02665_lanthipeptide

Lanthipeptides: KQY30_RS33045_lanthipeptide

4

TIITVGKSTLSVYKCN

19

+++ G S+LSV CN

5

SLLLCGDSSLSVVTCN

20

33.3%

NZ_BNCA01000002.1and 1 other:

NZ_CP049782.1 Lanthipeptides: G7Z12_RS34445_lanthipeptide

Lanthipeptides: IE314_RS02760_lanthipeptide

4

TIITVGKSTLSVYKCN

19

+++ G S+LSV CN

6

SLLLCGDSSLSVSTCN

21

33.3%

NZ_CP048835.1and 1 other:

NZ_CP092183.1 Lanthipeptides: COUCH_RS09770_lanthipeptide

Lanthipeptides: C8250_RS00390_lanthipeptide

4

TIITVGKSTLSVYKCN

19

+++ G S+LSV CN

6

SLLLCGNSSLSVTTCN

21

30.4%

NZ_QSNA01000006.1and 1 other:

NZ_VEAP01000011.1 Lanthipeptides: FS510_RS26445_lanthipeptide

Lanthipeptides: DX931_RS28505_lanthipeptide

1

ATITIITVGKSTLSVYKC

18

+ ++ I KST+SV+ C

1

SNLSFICKEKSTISVFTC

18

28.6%

NZ_BBOK01000011.1and 50 others:

NZ_BEWD01000001.1 Lanthipeptides: Sru02f_RS01660_lanthipeptideNZ_BMSL01000016.1 Lanthipeptides: IE215_RS23330_lanthipeptideNZ_BMUC01000023.1 Lanthipeptides: IE172_RS32210_lanthipeptideNZ_BMVE01000003.1 Lanthipeptides: IE248_RS10435_lanthipeptideNZ_BMVL01000005.1 Lanthipeptides: IE257_RS16230_lanthipeptideNZ_BMVQ01000005.1 Lanthipeptides: IE283_RS17035_lanthipeptideNZ_BMWI01000025.1 Lanthipeptides: IE253_RS33945_lanthipeptideNZ_CM002280.1 Lanthipeptides: M877_RS44575_lanthipeptideNZ_CP011664.1 Lanthipeptides: M444_RS30240_lanthipeptideNZ_CP012382.1 Lanthipeptides: SAM23877_RS30085_lanthipeptideNZ_CP012949.1 Lanthipeptides: SAM40697_RS29010_lanthipeptideNZ_CP018047.1 Lanthipeptides: BBN63_RS03065_lanthipeptideNZ_CP020039.1 Lanthipeptides: B4U39_RS34445_lanthipeptideNZ_CP020555.1 Lanthipeptides: B6R96_RS03515_lanthipeptideNZ_CP023701.1 Lanthipeptides: CP968_RS29065_lanthipeptideNZ_CP024087.1 Lanthipeptides: CSH63_RS05810_lanthipeptideNZ_CP029189.1 Lanthipeptides: DEJ51_RS31910_lanthipeptideNZ_CP030286.1 Lanthipeptides: DRB89_RS16930_lanthipeptideNZ_CP033581.1 Lanthipeptides: EES41_RS31595_lanthipeptideNZ_CP034350.1 Lanthipeptides: D1J60_RS32970_lanthipeptideNZ_CP042324.1 Lanthipeptides: FQ762_RS34495_lanthipeptideNZ_CP043638.1 Lanthipeptides: F1D59_RS34930_lanthipeptideNZ_CP043959.1 Lanthipeptides: F3L20_RS19105_lanthipeptideNZ_CP045547.1 Lanthipeptides: GEV49_RS05730_lanthipeptideNZ_CP048397.1 Lanthipeptides: SSPS47_RS31455_lanthipeptideNZ_CP054939.1 Lanthipeptides: HUT14_RS29815_lanthipeptideNZ_CP094918.1 Lanthipeptides: MTR79_RS16715_lanthipeptideNZ_CP115936.1 Lanthipeptides: PET44_RS28650_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS32700_lanthipeptideNZ_GG657756.1 Lanthipeptides: SSPG_RS05020_lanthipeptideNZ_GG657758.1 Lanthipeptides: SSRG_RS03855_lanthipeptideNZ_JAAALO010000001.1 Lanthipeptides: GVV04_RS02250_lanthipeptideNZ_JAAIFS010000001.1 Lanthipeptides: GUR47_RS02255_lanthipeptideNZ_JACHEM010000005.1 Lanthipeptides: HNQ79_RS11445_lanthipeptideNZ_JAFLQY010000003.1 Lanthipeptides: J0X20_RS29030_lanthipeptideNZ_JAINUL010000001.1 Lanthipeptides: K7B10_RS06210_lanthipeptideNZ_JANAVF010000017.1 Lanthipeptides: NLX94_RS31205_lanthipeptideNZ_KZ195574.1 Lanthipeptides: B9W62_RS05695_lanthipeptideNZ_LIVP01000027.1 Lanthipeptides: AMK15_RS28680_lanthipeptideNZ_LT629768.1 Lanthipeptides: BLU60_RS34110_lanthipeptideNZ_LWLD01000038.1 Lanthipeptides: A6A28_RS28600_lanthipeptideNZ_ML123038.1 Lanthipeptides: EES37_RS30340_lanthipeptideNZ_MQUH01000025.1 Lanthipeptides: BSZ07_RS33280_lanthipeptideNZ_NNBM01000002.1 Lanthipeptides: CG724_RS07855_lanthipeptideNZ_RAII01000001.1 Lanthipeptides: EBH12_RS10360_lanthipeptideNZ_RSEG01000006.1 Lanthipeptides: EIA57_RS12710_lanthipeptideNZ_SOAV01000001.1 Lanthipeptides: EV562_RS04520_lanthipeptideNZ_VIUV01000020.1 Lanthipeptides: FB570_RS34060_lanthipeptideNZ_WHZR01000001.1 Lanthipeptides: STPH1_RS04005_lanthipeptideNZ_WXVT01000001.1 Lanthipeptides: STPH2_RS03995_lanthipeptide

Lanthipeptides: APK71_RS25550_lanthipeptide

4

TIITVGKSTLSVYKCN

19

+++ G S+LS+ CN

6

SLLLCGDSSLSITTCN

21

28.1%

NZ_JAMXMK010000009.1and 1 other:

NZ_JAMXMK010000009.1 Lanthipeptides: NGM22_RS28055_lanthipeptide

Lanthipeptides: NGM22_RS28055_lanthipeptide

1

ATITIITVGKSTLSVYKC

18

A ITI G LS Y C

15

AGITIAAWGAHQLSYYNC

32

28.0%

NC_013131.1:

Lanthipeptides: CACI_RS49205_lanthipeptide

9

GKSTLSVYKCN

19

G S LSV CN

4

GDSGLSVTGCN

14

L3476_RS08485

Leader:

MNAVLELQKLAHDTDGKGQAAE

Core:

RTITIITIGKSTLSVYKCN

Core with dehydrations:

RDhbIDhbIIDhbIGKDhaDhbLDhaVYKCysN

antiSMASH-DB 4.0 matches for L3476_RS08485

100.0%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: L3476_RS08485_lanthipeptide

Lanthipeptides: FLT43_RS29600_lanthipeptide

1

RTITIITIGKSTLSVYKCN

19

RTITIITIGKSTLSVYKCN

1

RTITIITIGKSTLSVYKCN

19

89.5%

NZ_CP041405.1and 4 others:

NZ_CP041405.1 Lanthipeptides: FLT43_RS29605_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08480_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08475_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08470_lanthipeptide

Lanthipeptides: FLT43_RS29610_lanthipeptide

2

TITIITIGKSTLSVYKCN

19

TITIIT+GKSTLSVYKCN

2

TITIITVGKSTLSVYKCN

19

85.0%

Lanthipeptides: FLT43_RS29615_lanthipeptide

2

TITIITIGKSTLSVYKCN

19

TITIITIGKSTLSVY+CN

2

TITIITIGKSTLSVYQCN

19

with 15 more sequence matches

Only the first 10 are displayed here.

63.2%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: L3476_RS08510_lanthipeptide

Lanthipeptides: FLT43_RS29580_lanthipeptide

4

TIITIGKSTLSVYKC

18

TIITI S LSVYKC

5

TIITIC-SVLSVYKC

18

36.8%

NC_015434.1and 117 others:

NC_018750.1 Lanthipeptides: SVEN_RS32110_lanthipeptideNC_018750.1 Lanthipeptides: SVEN_RS32110_lanthipeptideNZ_BBNO01000003.1 Lanthipeptides: TU31_RS37940_lanthipeptideNZ_BMSV01000002.1 Lanthipeptides: IE106_RS06150_lanthipeptideNZ_BMTO01000007.1 Lanthipeptides: IE136_RS15615_lanthipeptideNZ_BMTP01000009.1 Lanthipeptides: IE109_RS18470_lanthipeptideNZ_BMTU01000009.1 Lanthipeptides: IE118_RS22890_lanthipeptideNZ_BMUN01000001.1 Lanthipeptides: IE238_RS00740_lanthipeptideNZ_CP007699.2 Lanthipeptides: T261_RS39185_lanthipeptideNZ_CP009754.1 Lanthipeptides: NI25_RS05015_lanthipeptideNZ_CP015866.1 Lanthipeptides: Spa2297_RS27800_lanthipeptideNZ_CP017157.1 Lanthipeptides: SL103_RS15895_lanthipeptideNZ_CP019457.1 Lanthipeptides: BXT88_RS03410_lanthipeptideNZ_CP019724.1 Lanthipeptides: B1H29_RS35355_lanthipeptideNZ_CP019779.1 Lanthipeptides: STRMOE7_RS03775_lanthipeptideNZ_CP020042.1 Lanthipeptides: B4U46_RS32710_lanthipeptideNZ_CP023202.1 Lanthipeptides: SXIN_RS23100_lanthipeptideNZ_CP023691.1 Lanthipeptides: CP981_RS03050_lanthipeptideNZ_CP023692.1 Lanthipeptides: CP980_RS04735_lanthipeptideNZ_CP023700.1 Lanthipeptides: CP969_RS04700_lanthipeptideNZ_CP027299.1 Lanthipeptides: C1N79_RS34970_lanthipeptideNZ_CP028158.1 Lanthipeptides: C6361_RS04660_lanthipeptideNZ_CP028159.1 Lanthipeptides: C6W10_RS01185_lanthipeptideNZ_CP029042.1 Lanthipeptides: DDE74_RS03525_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029195.1 Lanthipeptides: DEJ45_RS04995_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029196.1 Lanthipeptides: DEJ44_RS30395_lanthipeptideNZ_CP029541.1 Lanthipeptides: DKG71_RS05245_lanthipeptideNZ_CP034279.1 Lanthipeptides: EIZ62_RS28660_lanthipeptideNZ_CP034353.1 Lanthipeptides: D1J63_RS04900_lanthipeptideNZ_CP039123.1 Lanthipeptides: E5N77_RS35250_lanthipeptideNZ_CP043317.1 Lanthipeptides: FYC74_RS09720_lanthipeptideNZ_CP045309.1 Lanthipeptides: GCE86_RS12520_lanthipeptideNZ_CP046104.1 Lanthipeptides: GKC29_RS19975_lanthipeptideNZ_CP046905.1 Lanthipeptides: GPZ77_RS32930_lanthipeptideNZ_CP047140.1 Lanthipeptides: GLX30_RS11420_lanthipeptideNZ_CP050976.1 Lanthipeptides: HEP86_RS04470_lanthipeptideNZ_CP054920.1 Lanthipeptides: HUT15_RS04615_lanthipeptideNZ_CP059322.1 Lanthipeptides: H1D33_RS20095_lanthipeptideNZ_CP059322.1 Lanthipeptides: H1D33_RS20090_lanthipeptideNZ_CP060825.1 Lanthipeptides: IAG43_RS32355_lanthipeptideNZ_CP074111.1 Lanthipeptides: KE639_RS31630_lanthipeptideNZ_CP084681.1 Lanthipeptides: KI385_RS00885_lanthipeptideNZ_CP085300.1 Lanthipeptides: LJA35_RS05220_lanthipeptideNZ_CP086217.1 Lanthipeptides: LJ741_RS03435_lanthipeptideNZ_CP092183.1 Lanthipeptides: COUCH_RS09775_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS09690_lanthipeptideNZ_CP098437.1 Lanthipeptides: NCG97_RS34740_lanthipeptideNZ_CP099468.1 Lanthipeptides: NFX46_RS16770_lanthipeptideNZ_CP101137.1 Lanthipeptides: M6G08_RS24535_lanthipeptideNZ_CP102332.1 Lanthipeptides: NRO40_RS01140_lanthipeptideNZ_CP102609.1 Lanthipeptides: NUT86_RS03980_lanthipeptideNZ_CP104697.1 Lanthipeptides: N6Q81_RS33560_lanthipeptideNZ_CP114202.1 Lanthipeptides: STRLI_RS35870_lanthipeptideNZ_CP114203.1 Lanthipeptides: STRNI_RS37360_lanthipeptideNZ_CP114205.1 Lanthipeptides: STRTU_RS33380_lanthipeptideNZ_FMCR01000005.1 Lanthipeptides: GA0070561_RS23835_lanthipeptideNZ_FMCS01000001.1 Lanthipeptides: GA0070214_RS02345_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07020_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07015_lanthipeptideNZ_FMCU01000002.1 Lanthipeptides: GA0070216_RS07010_lanthipeptideNZ_FMDM01000002.1 Lanthipeptides: GA0070213_RS04970_lanthipeptideNZ_FNHI01000003.1 Lanthipeptides: BLT82_RS06465_lanthipeptideNZ_HF570108.1 Lanthipeptides: MILUP08_RS22425_lanthipeptideNZ_JACHJE010000006.1 Lanthipeptides: FHS32_RS15850_lanthipeptideNZ_JACHJI010000005.1 Lanthipeptides: FHS37_RS15430_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACSCH020000032.1 Lanthipeptides: E0F75_RS38565_lanthipeptideNZ_JACWAA010000001.1 Lanthipeptides: ICA23_RS00800_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09870_lanthipeptideNZ_JADMLH010000003.1 Lanthipeptides: IT780_RS09875_lanthipeptideNZ_JAFEJA010000002.1 Lanthipeptides: JE024_RS34830_lanthipeptideNZ_JAFEUO010000005.1 Lanthipeptides: JQN84_RS18770_lanthipeptideNZ_JAFEUO010000005.1 Lanthipeptides: JQN84_RS18765_lanthipeptideNZ_JAGFWR010000037.1 Lanthipeptides: JQN83_RS31375_lanthipeptideNZ_JAGFWR010000037.1 Lanthipeptides: JQN83_RS31370_lanthipeptideNZ_JAGGOI010000031.1 Lanthipeptides: J7E87_RS22160_lanthipeptideNZ_JAGPXN010000015.1 Lanthipeptides: KBX06_RS19685_lanthipeptideNZ_JAGPXN010000015.1 Lanthipeptides: KBX06_RS19680_lanthipeptideNZ_JAGPXW010000002.1 Lanthipeptides: KBX71_RS04195_lanthipeptideNZ_JAGPXX010000007.1 Lanthipeptides: KBZ10_RS10785_lanthipeptideNZ_JAGPYC010000033.1 Lanthipeptides: KBZ00_RS31440_lanthipeptideNZ_JAHLXF010000022.1 Lanthipeptides: KQY13_RS30555_lanthipeptideNZ_JAIHBQ010000001.1 Lanthipeptides: K4902_RS04515_lanthipeptideNZ_JAJJMU010000026.1 Lanthipeptides: LOC25_RS31275_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAJNOJ010000002.1 Lanthipeptides: MBT42_RS06255_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAMGSL010000004.1 Lanthipeptides: M5362_RS09920_lanthipeptideNZ_JAPKNL010000004.1 Lanthipeptides: OSI21_RS07750_lanthipeptideNZ_JAPNLM010000003.1 Lanthipeptides: OTB16_RS07305_lanthipeptideNZ_JH993790.1 Lanthipeptides: STRVIR_RS0131905_lanthipeptideNZ_KN039948.1 Lanthipeptides: FM21_RS29525_lanthipeptideNZ_LIPF01000004.1 Lanthipeptides: AMK11_RS16660_lanthipeptideNZ_LIVQ01000005.1 Lanthipeptides: AMK16_RS35205_lanthipeptideNZ_LIVQ01000005.1 Lanthipeptides: AMK16_RS35205_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVV01000002.1 Lanthipeptides: AMK27_RS08700_lanthipeptideNZ_LIVX01000004.1 Lanthipeptides: AMK29_RS15650_lanthipeptideNZ_LIWB01000010.1 Lanthipeptides: AMK33_RS24360_lanthipeptideNZ_LIYH01000004.1 Lanthipeptides: AMK26_RS17765_lanthipeptideNZ_LT607409.1 Lanthipeptides: GA0070612_RS21605_lanthipeptideNZ_LT607733.1 Lanthipeptides: GA0070610_RS13855_lanthipeptideNZ_LT607733.1 Lanthipeptides: GA0070610_RS13850_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04340_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04335_lanthipeptideNZ_LT607752.1 Lanthipeptides: GA0070623_RS04330_lanthipeptideNZ_MPOH02000012.1 Lanthipeptides: BM536_RS17150_lanthipeptideNZ_NBCN01000003.1 Lanthipeptides: BKD26_RS06570_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_NNBP01000011.1 Lanthipeptides: CG747_RS19290_lanthipeptideNZ_QGGR01000008.1 Lanthipeptides: BC793_RS19230_lanthipeptideNZ_RAIF01000032.1 Lanthipeptides: EBH09_RS35480_lanthipeptideNZ_RBAK01000011.1 Lanthipeptides: D7223_RS24620_lanthipeptideNZ_SOPG01000008.1 Lanthipeptides: E0I08_RS17090_lanthipeptide

Lanthipeptides: VAB18032_RS17930_lanthipeptide

4

TIITIGKSTLSVYKCN

19

+++ G S+LSV CN

2

SLLLCGDSSLSVTTCN

17

36.8%

NZ_BBOL01000008.1and 7 others:

NZ_BBOL01000008.1 Lanthipeptides: LPU61_RS25375_lanthipeptideNZ_CP058322.1 Lanthipeptides: HXZ27_RS14120_lanthipeptideNZ_CP058322.1 Lanthipeptides: HXZ27_RS14115_lanthipeptideNZ_FMCT01000009.1 Lanthipeptides: GA0070563_RS21095_lanthipeptideNZ_FMCT01000009.1 Lanthipeptides: GA0070563_RS21090_lanthipeptideNZ_FMCW01000007.1 Lanthipeptides: GA0070558_RS08825_lanthipeptideNZ_FMCW01000007.1 Lanthipeptides: GA0070558_RS08820_lanthipeptide

Lanthipeptides: LPU61_RS25380_lanthipeptide

4

TIITIGKSTLSVYKCN

19

+++ G S LSV CN

2

SLLLCGDSGLSVTTCN

17

35.0%

NZ_CP077658.1and 1 other:

NZ_JACHJG010000001.1 Lanthipeptides: FHS38_RS02665_lanthipeptide

Lanthipeptides: KQY30_RS33045_lanthipeptide

4

TIITIGKSTLSVYKCN

19

+++ G S+LSV CN

5

SLLLCGDSSLSVVTCN

20

33.3%

NZ_BNCA01000002.1and 1 other:

NZ_CP049782.1 Lanthipeptides: G7Z12_RS34445_lanthipeptide

Lanthipeptides: IE314_RS02760_lanthipeptide

4

TIITIGKSTLSVYKCN

19

+++ G S+LSV CN

6

SLLLCGDSSLSVSTCN

21

33.3%

NZ_CP048835.1and 1 other:

NZ_CP092183.1 Lanthipeptides: COUCH_RS09770_lanthipeptide

Lanthipeptides: C8250_RS00390_lanthipeptide

4

TIITIGKSTLSVYKCN

19

+++ G S+LSV CN

6

SLLLCGNSSLSVTTCN

21

30.4%

NZ_QSNA01000006.1and 1 other:

NZ_VEAP01000011.1 Lanthipeptides: FS510_RS26445_lanthipeptide

Lanthipeptides: DX931_RS28505_lanthipeptide

3

ITIITIGKSTLSVYKC

18

++ I KST+SV+ C

3

LSFICKEKSTISVFTC

18

28.6%

NZ_BBOK01000011.1and 50 others:

NZ_BEWD01000001.1 Lanthipeptides: Sru02f_RS01660_lanthipeptideNZ_BMSL01000016.1 Lanthipeptides: IE215_RS23330_lanthipeptideNZ_BMUC01000023.1 Lanthipeptides: IE172_RS32210_lanthipeptideNZ_BMVE01000003.1 Lanthipeptides: IE248_RS10435_lanthipeptideNZ_BMVL01000005.1 Lanthipeptides: IE257_RS16230_lanthipeptideNZ_BMVQ01000005.1 Lanthipeptides: IE283_RS17035_lanthipeptideNZ_BMWI01000025.1 Lanthipeptides: IE253_RS33945_lanthipeptideNZ_CM002280.1 Lanthipeptides: M877_RS44575_lanthipeptideNZ_CP011664.1 Lanthipeptides: M444_RS30240_lanthipeptideNZ_CP012382.1 Lanthipeptides: SAM23877_RS30085_lanthipeptideNZ_CP012949.1 Lanthipeptides: SAM40697_RS29010_lanthipeptideNZ_CP018047.1 Lanthipeptides: BBN63_RS03065_lanthipeptideNZ_CP020039.1 Lanthipeptides: B4U39_RS34445_lanthipeptideNZ_CP020555.1 Lanthipeptides: B6R96_RS03515_lanthipeptideNZ_CP023701.1 Lanthipeptides: CP968_RS29065_lanthipeptideNZ_CP024087.1 Lanthipeptides: CSH63_RS05810_lanthipeptideNZ_CP029189.1 Lanthipeptides: DEJ51_RS31910_lanthipeptideNZ_CP030286.1 Lanthipeptides: DRB89_RS16930_lanthipeptideNZ_CP033581.1 Lanthipeptides: EES41_RS31595_lanthipeptideNZ_CP034350.1 Lanthipeptides: D1J60_RS32970_lanthipeptideNZ_CP042324.1 Lanthipeptides: FQ762_RS34495_lanthipeptideNZ_CP043638.1 Lanthipeptides: F1D59_RS34930_lanthipeptideNZ_CP043959.1 Lanthipeptides: F3L20_RS19105_lanthipeptideNZ_CP045547.1 Lanthipeptides: GEV49_RS05730_lanthipeptideNZ_CP048397.1 Lanthipeptides: SSPS47_RS31455_lanthipeptideNZ_CP054939.1 Lanthipeptides: HUT14_RS29815_lanthipeptideNZ_CP094918.1 Lanthipeptides: MTR79_RS16715_lanthipeptideNZ_CP115936.1 Lanthipeptides: PET44_RS28650_lanthipeptideNZ_CP116355.1 Lanthipeptides: KPP03845_RS32700_lanthipeptideNZ_GG657756.1 Lanthipeptides: SSPG_RS05020_lanthipeptideNZ_GG657758.1 Lanthipeptides: SSRG_RS03855_lanthipeptideNZ_JAAALO010000001.1 Lanthipeptides: GVV04_RS02250_lanthipeptideNZ_JAAIFS010000001.1 Lanthipeptides: GUR47_RS02255_lanthipeptideNZ_JACHEM010000005.1 Lanthipeptides: HNQ79_RS11445_lanthipeptideNZ_JAFLQY010000003.1 Lanthipeptides: J0X20_RS29030_lanthipeptideNZ_JAINUL010000001.1 Lanthipeptides: K7B10_RS06210_lanthipeptideNZ_JANAVF010000017.1 Lanthipeptides: NLX94_RS31205_lanthipeptideNZ_KZ195574.1 Lanthipeptides: B9W62_RS05695_lanthipeptideNZ_LIVP01000027.1 Lanthipeptides: AMK15_RS28680_lanthipeptideNZ_LT629768.1 Lanthipeptides: BLU60_RS34110_lanthipeptideNZ_LWLD01000038.1 Lanthipeptides: A6A28_RS28600_lanthipeptideNZ_ML123038.1 Lanthipeptides: EES37_RS30340_lanthipeptideNZ_MQUH01000025.1 Lanthipeptides: BSZ07_RS33280_lanthipeptideNZ_NNBM01000002.1 Lanthipeptides: CG724_RS07855_lanthipeptideNZ_RAII01000001.1 Lanthipeptides: EBH12_RS10360_lanthipeptideNZ_RSEG01000006.1 Lanthipeptides: EIA57_RS12710_lanthipeptideNZ_SOAV01000001.1 Lanthipeptides: EV562_RS04520_lanthipeptideNZ_VIUV01000020.1 Lanthipeptides: FB570_RS34060_lanthipeptideNZ_WHZR01000001.1 Lanthipeptides: STPH1_RS04005_lanthipeptideNZ_WXVT01000001.1 Lanthipeptides: STPH2_RS03995_lanthipeptide

Lanthipeptides: APK71_RS25550_lanthipeptide

4

TIITIGKSTLSVYKCN

19

+++ G S+LS+ CN

6

SLLLCGDSSLSITTCN

21

28.0%

NC_013131.1:

Lanthipeptides: CACI_RS49205_lanthipeptide

9

GKSTLSVYKCN

19

G S LSV CN

4

GDSGLSVTGCN

14

27.3%

NZ_CP029560.1and 1 other:

NZ_JADOZM010000015.1 Lanthipeptides: allorf_00761_00913_lanthipeptide

Lanthipeptides: allorf_0494409_0494561_lanthipeptide

1

RTITIITIG------KSTLSVYKC

18

R ++ ++IG +ST+SVY+C

10

RVLSTVSIGCAGSCVRSTISVYRC

33

L3476_RS08490

Leader:

MNAVLELQKLAHNTDGKGQAID

Core:

ATPTTTVFPPPIYSTVSVSAWECLKN

Core with dehydrations:

ADhbPDhbDhbDhbVFPPPIYDhaDhbVDhaVDhaAWECysLKN

antiSMASH-DB 4.0 matches for L3476_RS08490

100.0%

NZ_CP094446.1:

Lanthipeptides: L3476_RS08490_lanthipeptide

1

ATPTTTVFPPPIYSTVSVSAWECLKN

26

ATPTTTVFPPPIYSTVSVSAWECLKN

1

ATPTTTVFPPPIYSTVSVSAWECLKN

26

65.4%

BGC0002130.3 (QKI29070.1):

Lanthipeptides: FLT43_RS29115_lanthipeptide

9

PPPIYSTVSVSAWECLKN

26

PPPIYSTVSVSAWEC KN

9

PPPIYSTVSVSAWECYKN

26

26.3%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

3

PTTTVFPPPIYSTVSVSAWEC

23

PTTTV T+ +SAW C

11

PTTTV-------TIPISAWGC

24

with 1 more sequence matches

20.6%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

2

TPTTTVFPPPIYSTVSVSAWECLKN

26

TP TT+ + S ++ + + C K+

8

TPATTLLASFVASYIASAEFRCGKD

32

MIBiG 4.0 matches for L3476_RS08490

26.9%

Lanthipeptide: cacaoidin

9

PPPIYSTVSV-----SAWEC

23

P IY++VS ++W C

4

PCTIYASVSASISATASWGC

23

L3476_RS08510

Leader:

MNAVLELQKLAHDTDGKGQAAD

Core:

AGITTIITICSVLSVYKCC

Core with dehydrations:

AGIDhbDhbIIDhbICysDhaVLDhaVYKCysCys

antiSMASH-DB 4.0 matches for L3476_RS08510

100.0%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: L3476_RS08510_lanthipeptide

Lanthipeptides: FLT43_RS29580_lanthipeptide

1

AGITTIITICSVLSVYKCC

19

AGITTIITICSVLSVYKCC

1

AGITTIITICSVLSVYKCC

19

63.2%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: L3476_RS08485_lanthipeptide

Lanthipeptides: FLT43_RS29600_lanthipeptide

5

TIITIC-SVLSVYKC

18

TIITI S LSVYKC

4

TIITIGKSTLSVYKC

18

57.9%

NZ_CP041405.1and 4 others:

NZ_CP041405.1 Lanthipeptides: FLT43_RS29605_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08480_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08475_lanthipeptideNZ_CP094446.1 Lanthipeptides: L3476_RS08470_lanthipeptide

Lanthipeptides: FLT43_RS29610_lanthipeptide

5

TIITIC-SVLSVYKC

18

TIIT+ S LSVYKC

4

TIITVGKSTLSVYKC

18

with 4 more sequence matches

55.0%

Lanthipeptides: FLT43_RS29615_lanthipeptide

5

TIITIC-SVLSVYKC

18

TIITI S LSVY+C

4

TIITIGKSTLSVYQC

18

18.9%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

2

GITTIITICSVLSV

15

G+ IT CS+LS+

4

GVAKSITSCSLLSI

17

16.0%

NZ_CP070496.1:

Lanthipeptides: allorf_3786998_3787234_lanthipeptide

1

AGITTIITICSVLS

14

AG IIT+C LS

25

AGSIQIITVCDGLS

38

12.5%

NZ_FNVT01000006.1:

Lanthipeptides: C4V41_RS24485_lanthipeptide

8

TICSVLSVYKCC

19

T CS Y+CC

37

TACSGSRTYQCC

48

allorf_1839268_1839411

Leader:

MKKMNAVLELQKLAHDTDGKGQAD

Core:

VIPTITTITTTRWSLTSNFLCRQ

Core with dehydrations:

VIPDhbIDhbDhbIDhbDhbDhbRWDhaLDhbDhaNFLCysRQ

antiSMASH-DB 4.0 matches for allorf_1839268_1839411

100.0%

NZ_CP041405.1and 1 other:

NZ_CP094446.1 Lanthipeptides: allorf_1839268_1839411_lanthipeptide

Lanthipeptides: allorf_0049226_0049369_lanthipeptide

1

VIPTITTITTTRWSLTSNFLCRQ

23

VIPTITTITTTRWSLTSNFLCRQ

1

VIPTITTITTTRWSLTSNFLCRQ

23

95.8%

Lanthipeptides: FLT43_RS29120_lanthipeptide

1

VIPTITTIT-TTRWSLTSNFLCRQ

23

VIPTITTIT TTRWSLTSNFLCRQ

1

VIPTITTITNTTRWSLTSNFLCRQ

24

41.4%

NZ_FOHE01000012.1:

Lanthipeptides: BMX40_RS20340_lanthipeptide

1

VIPTITTIT---TTRWSLTSN

18

V PTITT++ TT WS SN

3

VGPTITTVSAILTTFWSTVSN

23

with 4 more sequence matches

29.2%

NZ_CP084108.1and 2 others:

NZ_CP102383.1 Lanthipeptides: NP781_RS20720_lanthipeptideNZ_JAASJR010000006.1 Lanthipeptides: HCH28_RS14710_lanthipeptide

Lanthipeptides: LCP48_RS21615_lanthipeptide

13

WSLTSNFLC

21

+S TSNFLC

2

YSTTSNFLC

10

21.7%

NZ_KB946334.1:

Lanthipeptides: allorf_270990_271106_lanthipeptide

12

RWSLTSNFLCRQ

23

R + T+NF C +

2

RCAHTANFCCHE

13

18.4%

NZ_RYYV01000002.1:

Lanthipeptides: EKH80_RS03455_lanthipeptide

8

ITTTRWSLTSNFLC

21

I + S+T+NFLC

13

IVNSAESITTNFLC

26

18.2%

NZ_CABWKH010000001.1:

Lanthipeptides: allorf_024255_024410_lanthipeptide

1

VIPTITTITTTRWS

14

++P IT RWS

6

LVPPITMFGRLRWS

19

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 21.84 out of 21.84

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.51 out of 27.78

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.32 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.52 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.73 out of 39.62

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.50 out of 29.51

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

L3476_RS08470 - Class III

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 1903.1 Da

Molecular weight: 1904.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1922.3 Da N = 1; 1940.3 Da N = 2; 1958.3 Da N = 3; 1976.3 Da N = 4; 1994.4 Da N = 5

L3476_RS08475 - Class III

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 1903.1 Da

Molecular weight: 1904.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1922.3 Da N = 1; 1940.3 Da N = 2; 1958.3 Da N = 3; 1976.3 Da N = 4; 1994.4 Da N = 5

L3476_RS08480 - Class III

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 1903.1 Da

Molecular weight: 1904.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1922.3 Da N = 1; 1940.3 Da N = 2; 1958.3 Da N = 3; 1976.3 Da N = 4; 1994.4 Da N = 5

L3476_RS08485 - Class III

Cleavage pHMM score: 4.30

RODEO score: 0

Monoisotopic mass: 2002.2 Da

Molecular weight: 2003.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2021.4 Da N = 1; 2039.4 Da N = 2; 2057.4 Da N = 3; 2075.5 Da N = 4; 2093.5 Da N = 5

L3476_RS08490 - Class III

Cleavage pHMM score: -1.90

RODEO score: 0

Monoisotopic mass: 2664.4 Da

Molecular weight: 2666.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2684.0 Da N = 1; 2702.1 Da N = 2; 2720.1 Da N = 3; 2738.1 Da N = 4; 2756.1 Da N = 5; 2774.1 Da N = 6; 2792.2 Da N = 7

L3476_RS08510 - Class III

Cleavage pHMM score: 4.30

RODEO score: 0

Monoisotopic mass: 1897.0 Da

Molecular weight: 1898.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1916.4 Da N = 1; 1934.4 Da N = 2

allorf_1839268_1839411 - Class III

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 2489.4 Da

Molecular weight: 2490.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2508.9 Da N = 1; 2526.9 Da N = 2; 2544.9 Da N = 3; 2563.0 Da N = 4; 2581.0 Da N = 5; 2599.0 Da N = 6; 2617.0 Da N = 7; 2635.0 Da N = 8

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 7 - NRPS,NRPS-like,T1PKS,transAT-PKS

Download region SVG

Location: 2,318,324 - 2,440,593 nt. (total: 122,270 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

L3476_RS10825: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

L3476_RS10840: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

L3476_RS11040: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

L3476_RS11055: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: acylase

L3476_RS11010: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

L3476_RS11030: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase hydrolase phosphatase

L3476_RS10785: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

L3476_RS10835: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

L3476_RS10845: thioesterase

smcogs: SMCOG1004: thioesterase

L3476_RS10850: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: ligase synthase

L3476_RS10800: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

L3476_RS10805: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

L3476_RS10810: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

L3476_RS10815: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

L3476_RS10820: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS10855: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS11005: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS11025: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transporter

L3476_RS10720: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

L3476_RS10985: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	1.49	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	1.40	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001135.5	1.38	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	1.37	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	1.37	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	1.36	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	1.34	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	1.33	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	1.33	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	1.33	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.72	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001876.2	0.71	NRPS	thalassospiramide A	Thalassospira sp. CNJ-328
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.62 out of 27.55

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.56 out of 24.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.49 out of 24.78

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.19 out of 30.25

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.06 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.61 out of 24.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.45 out of 24.78

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.49 out of 20.47

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.37 out of 24.78

Confidence: medium

Additional weak hits (27):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.74 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.17 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.70 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.61 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.45 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.58 out of 21.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.73 out of 30.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.38 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.38 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.91 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.79 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.35 out of 27.55

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.86 out of 32.74

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.75 out of 29.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 36.54

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.58 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.04 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.75 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.44 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 7, location 2318323 - 2440593:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ohmal) + (Gly) + (D-Asn) + (Leu - ohmal - Leu) + (ohmal) + (mal - ohmal) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 2318323 - 2399464:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn) + (Leu - ohmal - Leu) + (ohmal) + (mal - ohmal) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 2383683 - 2425381:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ohmal) + (Gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 2385534 - 2440593:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ohmal) + (Gly)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS10800: mal

PKS_AT (535..829): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.5
inactive: 103.6
Methylmalonyl-CoA: 76.4
Methoxymalonyl-CoA: 75.1
Ethylmalonyl-CoA: 56.1
Propionyl-CoA: 48.7
2-Methylbutyryl-CoA: 41.9
Isobutyryl-CoA: 37.0
CHC-CoA: 29.5
Benzoyl-CoA: 26.2
fatty_acid: 19.8
trans-1,2-CPDA: 17.5
Acetyl-CoA: 12.7
3-Methylbutyryl-CoA: 0.0

L3476_RS10805: mal - mal

PKS_AT (533..824): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.4
inactive: 118.9
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 44.1
Isobutyryl-CoA: 25.4
Ethylmalonyl-CoA: 22.1
fatty_acid: 21.5
CHC-CoA: 21.5
2-Methylbutyryl-CoA: 18.6
Acetyl-CoA: 9.9
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1592..1889): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 181.2
inactive: 118.7
Methoxymalonyl-CoA: 76.0
Methylmalonyl-CoA: 66.2
Ethylmalonyl-CoA: 34.9
Isobutyryl-CoA: 34.6
Propionyl-CoA: 33.1
Benzoyl-CoA: 26.9
2-Methylbutyryl-CoA: 15.9
trans-1,2-CPDA: 13.9
fatty_acid: 11.5
CHC-CoA: 10.9
Acetyl-CoA: 9.9
3-Methylbutyryl-CoA: 0.0

L3476_RS10810: mal

PKS_AT (535..830): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 156.1
inactive: 97.7
Methoxymalonyl-CoA: 77.8
Methylmalonyl-CoA: 65.9
Ethylmalonyl-CoA: 40.6
Propionyl-CoA: 35.1
2-Methylbutyryl-CoA: 22.4
trans-1,2-CPDA: 16.7
Benzoyl-CoA: 11.7
fatty_acid: 9.6
Isobutyryl-CoA: 9.6
Acetyl-CoA: 3.8
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

L3476_RS10815: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (275..660): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASVWEPFLLTGGDFNNYGPTENTVVTTF
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS10820: Leu - mal

Search NORINE for peptide: strict or relaxed

AMP-binding (479..872): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LNTGFDALTFEGLLIVGGDWNAYGPTENTVISTC
Nearest Stachelhaus code(s):: Leu DAFLIGAVMK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

PKS_AT (1612..1904): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 115.2
Methoxymalonyl-CoA: 73.8
inactive: 64.2
Methylmalonyl-CoA: 62.8
Ethylmalonyl-CoA: 35.9
Isobutyryl-CoA: 34.5
CHC-CoA: 28.0
Propionyl-CoA: 24.3
Benzoyl-CoA: 15.2
3-Methylbutyryl-CoA: 7.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Acetyl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

L3476_RS10855: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (453..847): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSMKLIVGGEYNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS11005: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (0..374): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMTFDIFVLELQAMIGGEYNLYGPTETTIWSTV
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

L3476_RS11010: pk

PKS_AT (9..294): pk

ATSignature: (unknown)

No matches above 50%

minowa: inactive

Prediction, score:

inactive: 7.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Malonyl-CoA: -2.1

L3476_RS11030: mal

PKS_AT (6..289): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 59.6
inactive: 26.0
Methylmalonyl-CoA: 20.8
Methoxymalonyl-CoA: 20.1
Propionyl-CoA: 17.9
Benzoyl-CoA: 14.9
Isobutyryl-CoA: 9.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP094446.1 - Region 8 - NRPS,RiPP-like

Download region SVG

Location: 2,700,577 - 2,789,303 nt. (total: 88,727 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

L3476_RS12320: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

L3476_RS12400: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

L3476_RS12495: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: ligase

L3476_RS12410: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

L3476_RS12420: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

L3476_RS12430: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter

L3476_RS12345: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.48	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.47	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.47	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.45	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.45	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.45	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.42	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.41	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.40	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001166.5	0.39	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.77	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.76	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.73	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001166.5	0.71	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.19 out of 30.25

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.35 out of 18.57

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.07 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.73 out of 20.97

Confidence: medium

Additional weak hits (24):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.63 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.94 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.23 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.67 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.15 out of 26.85

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.68 out of 29.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.30 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.61 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.35 out of 28.14

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.15 out of 30.22

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.35 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.45 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.03 out of 36.54

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.22 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.32 out of 33.14

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.07 out of 23.43

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.59 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.80 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 11, location 2700576 - 2789303:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Orn - Tyr - Val) + (Gly - Orn - D-Tyr - Gly - D-X - Gly - Val - Asp)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 12, location 2700576 - 2782143:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Orn - Tyr - Val) + (Gly - Orn - D-Tyr - Gly - D-X - Gly - Val - Asp)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS12410: Gly - Orn - Tyr - Gly - X - Gly - Val - Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (691..1125): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMTFDIFAAEVQMLVGGEYNMYGPTETTVWSTC
Nearest Stachelhaus code(s):: Gly DILQLGMVWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1768..2174): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: RAWAFDVFVEDRNSILGGDINCYGVTEATVDSSF
Nearest Stachelhaus code(s):: Orn DVGEIGSVDK (68% 8Å match); Lys or Arg DVEDIGSVAK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (2828..3217): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWKSFDAFISHGQFVTGGEVSEYGPTENSVVTAA
Nearest Stachelhaus code(s):: Trp DPTQVGEVVK (68% 8Å match); Tyr DALAVGEVVK (65% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (4348..4782): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMTFDIFAAEVQMLVGGEYNMYGPTETTVWSTF
Nearest Stachelhaus code(s):: Gly DILQLGMVWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (5448..5837): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWKSFDASITHGQFVTGGEVSEYGPTENSVVTAA
Nearest Stachelhaus code(s):: Trp DPTQVGEVVK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (6956..7355): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMTFDIFAAEVQMLVGGEYNMYGPTETTVWSTF
Nearest Stachelhaus code(s):: Gly DILQLGMVWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (8000..8419): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNGFDAATFEGFLIMGGEWNGYGPTENTTFSTA
Nearest Stachelhaus code(s):: Val DAFFIGGTFK (71% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (9063..9466): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTASKMVLGGEMQHYGPTETTIGSIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS12420: X

Search NORINE for peptide: strict or relaxed

AMP-binding (18..285): X

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LYQAFDVSYQETYLITAG----------------
Nearest Stachelhaus code(s):: Pro DVQYIAHVVK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

L3476_RS12430: Orn - Tyr - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (478..883): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: TAWAFDVFAGDRESILGSDLNSYGVTEACIDASY
Nearest Stachelhaus code(s):: Orn DVGEIGSIDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1920): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWKNFDSFVTHGQSVLAGEMNEYGPTENTVVTTA
Nearest Stachelhaus code(s):: Trp DPTQVGEVVK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2562..2984): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNAGFDAATFEGFLIMGGEWNGYGPTENTTFSTA
Nearest Stachelhaus code(s):: Val DAFFIGGTFK (71% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_CP094446.1 - Region 9 - terpene

Download region SVG

Location: 2,976,108 - 2,997,970 nt. (total: 21,863 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

L3476_RS13380: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: aminotransferase

L3476_RS13340: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

L3476_RS13405: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002402.2	0.41	terpene	Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V	Spinacia oleracea
BGC0001314.3	0.40	terpene	tirucalla	Arabidopsis thaliana
BGC0000670.4	0.39	terpene	thalianol, thaliandiol, thalianin	Arabidopsis thaliana
BGC0000663.5	0.34	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000453.5	0.34	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0002448.2	0.32	NRPS	Q6402A	Streptomyces violaceusniger
BGC0000274.5	0.30	PKS	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0002282.2	0.29	other (other)	formycin A	Streptomyces kaniharaensis
BGC0002040.3	0.29	other (other)	coformycin, formycin A	Streptomyces kaniharaensis
BGC0001985.4	0.27	other (other)	Pyrazofurin	Streptomyces candidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002402.2	0.41	terpene	Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V	Spinacia oleracea
BGC0001314.3	0.40	terpene	tirucalla	Arabidopsis thaliana
BGC0000670.4	0.39	terpene	thalianol, thaliandiol, thalianin	Arabidopsis thaliana
BGC0000663.5	0.34	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000453.5	0.34	NRPS	valinomycin	Streptomyces tsusimaensis
BGC0002448.2	0.32	NRPS	Q6402A	Streptomyces violaceusniger
BGC0000274.5	0.30	PKS	tetarimycin A, tetarimycin B	uncultured bacterium
BGC0002282.2	0.29	other (other)	formycin A	Streptomyces kaniharaensis
BGC0002040.3	0.29	other (other)	coformycin, formycin A	Streptomyces kaniharaensis
BGC0001985.4	0.27	other (other)	Pyrazofurin	Streptomyces candidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

L3476_RS13390: T2TS

Domain 1 (12 - 618): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.07 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.06 out of 28.19

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.86 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.31 out of 30.97

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.08 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.56 out of 29.38

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 10 - NRPS,proteusin

Download region SVG

Location: 3,428,686 - 3,478,365 nt. (total: 49,680 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
proteusin: (PoyD or TIGR03793)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase

L3476_RS15685: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

L3476_RS15630: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

L3476_RS15755: hydrolase

smcogs: SMCOG1179: hydrolase

Ligases: ligase

L3476_RS15680: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.36	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.33	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.32	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.32	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.31	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.31	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.30	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.30	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.30	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.29	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.65	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.57 out of 29.38

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.02 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.46 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.19 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 25.31

Confidence: medium

Additional weak hits (38):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.22 out of 30.22

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.91 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.36 out of 27.78

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.34 out of 30.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.65 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.15 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.67 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.53 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.62 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.27 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.95 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.50 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.26 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.37 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.85 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.92 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.41 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.33 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.52 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.85 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.33 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.33 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.25 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.29 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.51 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.84 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.52 out of 28.14

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.26 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.89 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.21 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.33 out of 36.54

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.52 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.39 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.42 out of 33.14

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.19 out of 23.43

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 15, location 3428685 - 3478365:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 16, location 3428685 - 3475438:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - Val)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS15680: Ile - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (219..612): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTGFDASTFEGFLFVGGESNIYGPTENTTFSTC
Nearest Stachelhaus code(s):: Ile DAFFLGITFK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1253..1652): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTGFDASTFEGWLLVGGDINGYGPTENTTFTAC
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 11 - NRP-metallophore,NRPS

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Location: 3,645,762 - 3,697,693 nt. (total: 51,932 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

L3476_RS16700: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

L3476_RS16685: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

L3476_RS16695: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

L3476_RS16680: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.5	0.85	NRPS	enterobactin	Pseudomonas sp. J465
BGC0000401.5	0.70	NRPS	paenibactin	Paenibacillus elgii B69
BGC0001185.5	0.66	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.64	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0000401.5	0.68	NRPS	paenibactin	Paenibacillus elgii B69
BGC0001185.5	0.66	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.65	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001250.4	0.63	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.63	NRPS	epichloenin A	Epichloe festucae
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.40 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.59 out of 18.57

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.39 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 25.96 out of 30.98

Confidence: medium

Additional weak hits (23):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.70 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.93 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.82 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.91 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.75 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.33 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.84 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.62 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.38 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.94 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.90 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.86 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.82 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.10 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.24 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.66 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.76 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.47 out of 30.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.95 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.80 out of 28.19

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

L3476_RS16680: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (464..867): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LCMTFDISVMELQAITGGENNQYGPTETTIYSTA
Nearest Stachelhaus code(s):: Ala DILQIGQIYK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
NuR	Nickel-responsive regulator
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 12 - ranthipeptide

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Location: 3,749,942 - 3,771,569 nt. (total: 21,628 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase protease

L3476_RS17095: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

L3476_RS17115: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

L3476_RS17130: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.50	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.41	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000600.3	0.41	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002667.2	0.39	ribosomal	estericin A	Clostridium estertheticum
BGC0000483.5	0.38	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0000595.3	0.38	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000597.4	0.38	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000502.5	0.38	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.50	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.41	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000600.3	0.41	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002667.2	0.39	ribosomal	estericin A	Clostridium estertheticum
BGC0000483.5	0.38	ribosomal	aeruginosamide B, aeruginosamide C	Microcystis aeruginosa PCC 9432
BGC0000595.3	0.38	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000597.4	0.38	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000502.5	0.38	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.54 out of 20.01

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.42 out of 20.97

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.32 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.11 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.10 out of 24.78

Confidence: medium

Additional weak hits (10):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.54 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.32 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.42 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.52 out of 29.25

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.65 out of 29.51

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.52 out of 26.06

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 99; Score: 106.9

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP094446.1 - Region 13 - lassopeptide

Download region SVG

Location: 4,267,915 - 4,291,804 nt. (total: 23,890 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

L3476_RS19305: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: glycosyltransferase

L3476_RS19385: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

L3476_RS19325: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: dehydratase

L3476_RS19365: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.92	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0002312.2	0.52	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001176.4	0.52	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001550.3	0.52	ribosomal	citrulassin D	Streptomyces katrae
BGC0001552.3	0.52	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000575.5	0.52	ribosomal	lariatin	Rhodococcus jostii
BGC0001549.3	0.51	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0002298.2	0.51	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0000571.3	0.50	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.92	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0002312.2	0.52	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001176.4	0.52	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001550.3	0.52	ribosomal	citrulassin D	Streptomyces katrae
BGC0001552.3	0.52	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000575.5	0.52	ribosomal	lariatin	Rhodococcus jostii
BGC0001549.3	0.51	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0002298.2	0.51	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0000571.3	0.50	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for L3476_RS19330

L3476_RS19330

Leader:

MKKQYSKPSLEVLDVHQTMA

Full core:

GPGLSTPDAFQPDPDEDVHYDPMDS

Putative macrolactam:

GPGLSTPD

antiSMASH-DB 4.0 matches for L3476_RS19330

100.0%

NZ_CP041405.1and 2 others:

NZ_CP094446.1 Lassopeptides: L3476_RS19330_lassopeptideNZ_CP106992.1 Lassopeptides: NDS46_RS02035_lassopeptide

Lassopeptides: FLT43_RS18930_lassopeptide

1

GPGLSTPDAFQPDPDEDVHYDPMDS

25

GPGLSTPDAFQPDPDEDVHYDPMDS

1

GPGLSTPDAFQPDPDEDVHYDPMDS

25

96.0%

NZ_AP025344.1:

Lassopeptides: L6439_RS00940_lassopeptide

1

GPGLSTPDAFQPDPDEDVHYDPMDS

25

GPG STPDAFQPDPDEDVHYDPMDS

1

GPGTSTPDAFQPDPDEDVHYDPMDS

25

80.0%

NZ_OX216966.1:

Lassopeptides: NNL35_RS04670_lassopeptide

1

GPGLSTPDAFQPDPDEDVHYD

21

GPG STPDAFQPDPDEDVHYD

1

GPGTSTPDAFQPDPDEDVHYD

21

with 54 more sequence matches

Only the first 10 are displayed here.

64.0%

NC_017138.1and 11 others:

NZ_CP018874.1 Lassopeptides: BUW91_RS28875_lassopeptideNZ_CP028084.1 Lassopeptides: C1N54_RS05380_lassopeptideNZ_JANIOE010000001.1 Lassopeptides: NQ109_RS19625_lassopeptideNZ_NGUL01000003.1 Lassopeptides: CBE78_RS15420_lassopeptideNZ_NTZG01000008.1 Lassopeptides: CN510_RS30020_lassopeptideNZ_NUEC01000009.1 Lassopeptides: CN635_RS27505_lassopeptideNZ_NUOI01000031.1 Lassopeptides: COE08_RS30705_lassopeptideNZ_NVEG01000005.1 Lassopeptides: COL08_RS29985_lassopeptideNZ_NVEV01000001.1 Lassopeptides: COL23_RS28065_lassopeptideNZ_VDTN01000001.1 Lassopeptides: FS483_RS07665_lassopeptideNZ_VEEA01000001.1 Lassopeptides: FS744_RS11845_lassopeptide

Lassopeptides: BMWSH_RS26600_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPG S PDA QPDPDE VHY

1

GPGTSIPDAVQPDPDETVHY

20

64.0%

NZ_CM000754.1and 7 others:

NZ_CP020723.1 Lassopeptides: B7P25_RS28625_lassopeptideNZ_CP023179.1 Lassopeptides: CK938_RS28520_lassopeptideNZ_CP085399.1 Lassopeptides: LIS81_RS18060_lassopeptideNZ_FTLZ01000002.1 Lassopeptides: BW973_RS28715_lassopeptideNZ_PIYQ01000023.1 Lassopeptides: CW365_RS28935_lassopeptideNZ_VDNI01000012.1 Lassopeptides: FSV62_RS19525_lassopeptideNZ_WBPF01000005.1 Lassopeptides: F8162_RS06315_lassopeptide

Lassopeptides: BTHUR0009_RS30905_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPGL TPDA QPD DE VHY

1

GPGLKTPDAVQPDIDEVVHY

20

64.0%

NZ_CP032365.1and 8 others:

NZ_FMBE01000013.1 Lassopeptides: CCY88_RS31005_lassopeptideNZ_FMJI01000046.1 Lassopeptides: CCY61_RS30520_lassopeptideNZ_FMZR01000002.1 Lassopeptides: BLS53_RS31385_lassopeptideNZ_JH791975.1 Lassopeptides: IEI_RS31960_lassopeptideNZ_JYPF01000002.1 Lassopeptides: TU50_RS30650_lassopeptideNZ_NUFG01000001.1 Lassopeptides: CN694_RS29875_lassopeptideNZ_NURJ01000008.1 Lassopeptides: COE89_RS29040_lassopeptideNZ_QOSC01000009.1 Lassopeptides: DN392_RS14315_lassopeptide

Lassopeptides: D4A37_RS18780_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPGL TPDA QPD DE VHY

1

GPGLKTPDAVQPDVDEVVHY

20

64.0%

NZ_NUPF01000007.1:

Lassopeptides: COE35_RS26755_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPGLS PDA Q DPDE VHY

1

GPGLSIPDAVQSDPDETVHY

20

64.0%

NZ_SDLR01000004.1:

Lassopeptides: EIZ58_RS19635_lassopeptide

1

GPGLSTPDAFQPDPDEDVHYD

21

GPG++TPDAFQPDPDE +HY+

1

GPGVTTPDAFQPDPDETIHYE

21

60.0%

NZ_CP030028.1:

Lassopeptides: DOE78_RS20570_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPG+ TPDA QPD DE VHY

1

GPGIKTPDASQPDVDEVVHY

20

60.0%

NZ_CP041063.1:

Lassopeptides: FJM75_RS10710_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPGL TPDA QPD DE +HY

1

GPGLKTPDAVQPDVDESIHY

20

60.0%

NZ_JAIEZS010000055.1and 1 other:

NZ_JH792165.1 Lassopeptides: IIO_RS35460_lassopeptide

Lassopeptides: K0820_RS18465_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPG+ TPDA QPD DE VHY

1

GPGIKTPDAVQPDVDEVVHY

20

60.0%

NZ_JAQQWU010000003.1:

Lassopeptides: PQ511_RS07455_lassopeptide

1

GPGLSTPDAFQPDPDEDVHY

20

GPG+ TPDA QPD DE VHY

1

GPGIKTPDAVQPDVDEAVHY

20

60.0%

NZ_KI632505.1:

Lassopeptides: V180_RS32040_lassopeptide

1

GPGLSTPDAFQPDPD----EDVHY

20

GPG+ TPDA QPDPD + VHY

1

GPGIKTPDAVQPDPDAPLKDQVHY

24

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.75 out of 23.05

Confidence: medium

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.66 out of 29.51

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.29 out of 29.25

Confidence: medium

Additional weak hits (2):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.69 out of 21.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.08 out of 28.14

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

L3476_RS19330 - Class II: Cleavage pHMM score: -9.90; RODEO score: 16; Monoisotopic mass: 2683.1 Da; Molecular weight: 2684.7 Da; Number of bridges: 0

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 16 - 94; Score: 78.6

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
DosR	Hypoxia stress response regulator
SypG	Regulator of biofilm formation and host colonization

NZ_CP094446.1 - Region 14 - phosphonate

Download region SVG

Location: 4,415,215 - 4,428,372 nt. (total: 13,158 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

L3476_RS19990: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: aminotransferase

L3476_RS19985: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.4	0.48	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000897.5	0.47	other (other)	dehydrophos	Streptomyces luridus
BGC0002036.4	0.43	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0001739.3	0.42	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000904.5	0.42	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002670.2	0.40	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000926.5	0.39	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000937.5	0.38	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000496.5	0.36	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000938.5	0.36	other (aminocoumarin)	fosfomycin	Streptomyces fradiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.4	0.48	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000897.5	0.47	other (other)	dehydrophos	Streptomyces luridus
BGC0002036.4	0.43	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0001739.3	0.42	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000904.5	0.42	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002670.2	0.40	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000926.5	0.39	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000937.5	0.38	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000496.5	0.36	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000938.5	0.36	other (aminocoumarin)	fosfomycin	Streptomyces fradiae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.38 out of 24.78

Confidence: medium

Additional weak hits (4):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.49 out of 28.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.13 out of 29.65

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.11 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response

NZ_CP094446.1 - Region 15 - lanthipeptide-class-ii

Download region SVG

Location: 5,259,520 - 5,282,573 nt. (total: 23,054 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carbamoyltransferase

L3476_RS23780: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Hydrolases: hydrolase protease

L3476_RS23795: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

L3476_RS23840: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase lyase

L3476_RS23790: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

L3476_RS23815: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase

L3476_RS23785: argininosuccinate synthase

smcogs: SMCOG1291: argininosuccinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.63	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.56	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001407.5	0.50	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.63	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.56	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001407.5	0.50	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for L3476_RS23815

L3476_RS23820

Leader:

MNNQLEHSPVGKSLKSLSEEEMASIFGG

Core:

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

Core with dehydrations:

DGMDVEVRDhaDhbLICysGVGADhaFIGDhaYLADhaAAFKCysGKKNKK

antiSMASH-DB 4.0 matches for L3476_RS23820

100.0%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23820_lanthipeptide

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

76.3%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25235_lanthipeptide

2

GMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNK

36

GMD E RSTLICG G S IGSYLASAAFKCGK NK

2

GMDAEARSTLICGAGISLIGSYLASAAFKCGKDNK

36

75.7%

Lanthipeptides: FLT43_RS14405_lanthipeptide

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNK

36

+GMDVEVRS+L+CG G S++ SYLASAAFKCGKKNK

1

NGMDVEVRSSLVCGAGISYVASYLASAAFKCGKKNK

36

with 28 more sequence matches

Only the first 10 are displayed here.

75.7%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08665_lanthipeptide

2

GMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

GMD EVRSTL+CG+G SF+ SYLASAAFKCGK NK

2

GMDAEVRSTLLCGMGISFVASYLASAAFKCGKDNKN

37

62.2%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00310_lanthipeptide

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

+G D +VRST IC G SFI +YL SAA CGK NKK

1

NGADADVRSTPICSAGISFIATYLGSAATNCGKDNKK

37

62.2%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

4

DVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

DV+VRS+L+C SF+GSYLASA KCGK NKK

3

DVDVRSSLVCSALLSFVGSYLASAGLKCGKDNKK

36

59.5%

NC_003028.3and 45 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

DG D RST+IC SFI SYL SA +CGK NKK

2

DGADP--RSTIICSATLSFIASYLGSAQTRCGKDNKK

36

59.5%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

DG D RST IC SFI SYL SA +CGK NKK

2

DGADP--RSTTICSATLSFIASYLGSAQTRCGKDNKK

36

56.8%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06305_lanthipeptide

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

DG D RS++IC SFI SYL SA +CGK NKK

2

DGADP--RSSIICSATLSFIASYLGSAQTRCGKDNKK

36

55.3%

NZ_CP084237.1:

Lanthipeptides: RES5_RS11640_lanthipeptide

4

DVEVRSTLICGVGASFIGS----YLASAAFKCGKKNKK

37

+VE+R T G+ ASF+ + Y ASAAFKCGK NKK

2

EVELRGTPTIGI-ASFVATIPTGYTASAAFKCGKDNKK

38

48.6%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

5

VEVRSTLICGVGASFIGSYLASAAFKCGKKNK

36

V+ R+T + ASF+ SY+ASA FKCGK NK

3

VDPRTT-PSPLLASFVASYIASAEFKCGKDNK

33

45.9%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

5

VEVRSTLICGVGASFIGSYLASAAFKCGKKNK

36

V+ R+T + ASF+ SY+ASA F+CGK NK

3

VDPRTT-PSPLLASFVASYIASAEFRCGKDNK

33

45.9%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

5

VEVRSTLICGVGASFIGSYLASAAFKCGKKNK

36

V+ R+T + ASF+ SY+ASA F+CGK NK

3

VDPRTT-PSPLLASFVASYIASAQFRCGKDNK

33

L3476_RS23825

Leader:

MTQEEIKLMNHSCGSGLKSLSREEMQNIYGA

Core:

SDVEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

Core with dehydrations:

DhaDVEPRGDhbPADhbIVDhaAVDhbRDhaDhaKPCysIDhaAIGDhaAIDhaGIIDhaHNKDCysLG

antiSMASH-DB 4.0 matches for L3476_RS23825

100.0%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

1

SDVEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

SDVEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

1

SDVEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

66.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

1

SDVEPRGTPAT--IVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

+D +PR TPA ++SAV RS++ CIS IGSAISGI+SHNKDCLG

1

ADADPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG

45

65.2%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08660_lanthipeptide

1

SDVEPRGTP---ATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

SDV+PR TP A+I+ +V +SSK CISA+GSAISGI+S+NK+CLG

1

SDVDPRATPTIVASIIRSVAQSSKVCISAVGSAISGIVSNNKNCLG

46

with 54 more sequence matches

Only the first 10 are displayed here.

62.8%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

3

VEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

VEP TP I+SA T+SSK C+ AI SAISG++S+NKDCLG

4

VEPHTTP--ILSAATKSSKKCLGAI-SAISGLVSYNKDCLG

41

60.9%

Lanthipeptides: FLT43_RS14400_lanthipeptide

1

SDVEPRGTPA---TIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

SDVEPR TP I +AV SSK C+S + SAI GI SHN DCLG

1

SDVEPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG

46

58.1%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27550_lanthipeptide

1

SDVEPRGTPATIVSAVTR-SSKPCISAIGSAISGIISHNKDCLG

43

S V+ R P IV V+R SS C S I SAISG++S+NKDCLG

1

SGVDTRTHPTVIV--VSRISSAKCASTI-SAISGLVSYNKDCLG

41

57.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16390_lanthipeptide

Lanthipeptides: KNQ12_RS14665_lanthipeptide

1

SDVEPRGTP--ATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

SDV+PR TP + + ++ +S+K CI A SAISGI+SHNKDCLG

1

SDVDPRWTPVISLVARSIVKSTKACIGAGASAISGIVSHNKDCLG

45

55.8%

NZ_KB976303.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide

Lanthipeptides: IGY_RS26045_lanthipeptide

1

SDVEPRGTPATIVSAVTR-SSKPCISAIGSAISGIISHNKDCLG

43

S V+ R P IV V+R SSK C+S + SAISG++S+NKDC+G

1

SGVDTRTHPTVIV--VSRASSKACMSGV-SAISGLLSYNKDCIG

41

55.6%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06300_lanthipeptide

4

EPRGTPA-TIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

EP TP TI+ + RSSK CISAI S I GI S+N DCLG

5

EPLWTPTPTILKSAARSSKVCISAIISGIGGIFSYNNDCLG

45

53.3%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

4

EPRGTPA-TIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

43

EPR TP I+ + T SSK CISA+ S I GI+S+N DCLG

5

EPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNNDCLG

45

51.1%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25230_lanthipeptide

1

SDVEPRGTPATIVSAVTRSS--KPCISAIGSAISGIISHNKDCLG

43

SDV+PR TP + + + K CISA+GSAI GI+S+NK+C G

1

SDVDPRWTPIASAAINSAARSSKICISAVGSAIGGIVSYNKNCAG

45

48.9%

NC_003028.3and 39 others:

NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptideNZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide

Lanthipeptides: SP_RS09790_lanthipeptide

4

EPRGTPATIV-SAVTRSSKPCISAIGSAISGIISHNKDCLG

43

EPR TP I+ + SSK CISA S I G++S+N DCLG

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

48.9%

NZ_CP035244.1and 3 others:

NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide

Lanthipeptides: EQH36_RS09100_lanthipeptide

4

EPRGTPATIV-SAVTRSSKPCISAIGSAISGIISHNKDCLG

43

EPR TP I+ + SSK CISA S I G++S+N DCLG

5

EPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG

45

allorf_5277560_5277673

Leader:

MAFPLVGLPVVRSDIFRMMRNAEPRAGRKKMLNFA

Core:

CS

Core with dehydrations:

CysDha

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40

Confidence: strong

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 21.65 out of 33.14

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

L3476_RS23820 - Class II

Cleavage pHMM score: 2.60

RODEO score: 0

Monoisotopic mass: 3760.0 Da

Molecular weight: 3762.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3780.4 Da N = 1; 3798.4 Da N = 2; 3816.4 Da N = 3

L3476_RS23825 - Class II

Cleavage pHMM score: 3.00

RODEO score: 0

Monoisotopic mass: 4096.2 Da

Molecular weight: 4098.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4116.6 Da N = 1; 4134.7 Da N = 2; 4152.7 Da N = 3; 4170.7 Da N = 4; 4188.7 Da N = 5; 4206.7 Da N = 6; 4224.8 Da N = 7; 4242.8 Da N = 8; 4260.8 Da N = 9

allorf_5277560_5277673 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 190.1 Da

Molecular weight: 190.2 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
HypR	L-hydroxyproline utilization repressor
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP094446.1 - Region 16 - NRPS

Download region SVG

Location: 5,422,085 - 5,503,236 nt. (total: 81,152 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

L3476_RS24825: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: aminotransferase

L3476_RS24710: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: ligase

L3476_RS24715: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

L3476_RS24720: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

L3476_RS24740: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000408.5	0.85	NRPS	polymyxin	Paenibacillus polymyxa
BGC0001192.5	0.84	NRPS	colistin A, colistin B	Paenibacillus alvei
BGC0001153.5	0.84	NRPS	polymyxin B	Paenibacillus polymyxa
BGC0002653.2	0.82	NRPS	macolacin	Paenibacillus xylanexedens
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000426.5	0.73	NRPS	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000408.5	0.85	NRPS	polymyxin	Paenibacillus polymyxa
BGC0001192.5	0.84	NRPS	colistin A, colistin B	Paenibacillus alvei
BGC0001153.5	0.84	NRPS	polymyxin B	Paenibacillus polymyxa
BGC0002653.2	0.82	NRPS	macolacin	Paenibacillus xylanexedens
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000426.5	0.73	NRPS	sevadicin	Paenibacillus larvae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.46 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.15 out of 27.78

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.41 out of 20.97

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.87 out of 27.55

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

Additional weak hits (21):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.01 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.96 out of 27.78

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.43 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 30.25

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.62 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.43 out of 29.65

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.53 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.47 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.97 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.34 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.62 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.71 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.59 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.97 out of 35.63

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 22.61 out of 30.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.03 out of 32.93

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.58 out of 30.11

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.20 out of 32.93

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.25 out of 29.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 23, location 5422084 - 5503236:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Leu - Thr - Dab - Thr) + (Dab - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

L3476_RS24715: Leu - Thr - Dab

Search NORINE for peptide: strict or relaxed

AMP-binding (293..683): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LMFAFDASCWEKILVTGGSFNAYGPTEASIVTTL
Nearest Stachelhaus code(s):: Leu DAWIVGAIVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1800..2207): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2849..3288): Dab

nrpys: Dab

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: TGYAFDVFVGDRESITSSDINAYGVTEAAIDSSF
Nearest Stachelhaus code(s):: Dab DVGEISAIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS24720: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (269..676): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

L3476_RS24740: Dab - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (466..878): Dab

nrpys: Dab

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: TAYAFDVFVGDRESITSSDINSYGVTEAAIDSSF
Nearest Stachelhaus code(s):: Dab DVGEISSIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1520..1927): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNDHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_CP094446.1 - Region 17 - ectoine

Download region SVG

Location: 5,561,408 - 5,571,791 nt. (total: 10,384 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

L3476_RS25190: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.73	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.73	other (ectoine)	ectoine	Streptomyces sp.
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.72	other (other)	ectoine	Methylomicrobium kenyense
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.60	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.73	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.73	other (ectoine)	ectoine	Streptomyces sp.
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.72	other (other)	ectoine	Methylomicrobium kenyense
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.60	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

NZ_CP094446.1 - Region 18 - azole-containing-RiPP