LOCUS       NZ_CP094446            23054 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Paenibacillus thiaminolyticus strain Mbale2 chromosome, complete
            genome.
ACCESSION   NZ_CP094446
VERSION     NZ_CP094446.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6487160)
  AUTHORS   Hehnly,C., Shi,A., Ssentongo,P., Zhang,L., Isaacs,A., Morton,S.U.,
            Streck,N., Erdmann-Gilmore,P., Tolstoy,I., Townsend,R.R.,
            Limbrick,D.D., Paulson,J.N., Ericson,J.E., Galperin,M.Y.,
            Schiff,S.J. and Broach,J.R.
  TITLE     Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of
            Paenibacillus thiaminolyticus
  JOURNAL   mBio 13 (6), e0268822 (2022)
   PUBMED   36374038
REFERENCE   2  (bases 1 to 6487160)
  AUTHORS   Zhang,L. and Hehnly,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2022) Institute for Personalized Medicine,
            Pennsylvania State University College of Medicine, 500 University
            Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-APR-2021
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_P.thiaminolyticus_Mbale2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028554415.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 07:15:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,780
            Genes (coding)                    :: 5,579
            CDSs (with protein)               :: 5,579
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 201
            CDSs (without protein)            :: 201
            Pseudo Genes (ambiguous residues) :: 0 of 201
            Pseudo Genes (frameshifted)       :: 146 of 201
            Pseudo Genes (incomplete)         :: 68 of 201
            Pseudo Genes (internal stop)      :: 17 of 201
            Pseudo Genes (multiple problems)  :: 26 of 201
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:53:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5259519
            Orig. end                         :: 5282573
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094446.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bacteria and source DNA
            available from Schiff/Broach Lab, 500 University Drive Hershey, PA
            17033.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23054
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="15"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23054
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23054
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13054](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13054)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            543..1490
                     /gene="argF"
                     /locus_tag="L3476_RS23780"
                     /old_locus_tag="L3476_23725"
     CDS             543..1490
                     /EC_number="2.1.3.3"
                     /GO_function="GO:0004585 - ornithine carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674750.1"
                     /locus_tag="L3476_RS23780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23725"
                     /product="ornithine carbamoyltransferase"
                     /protein_id="WP_143802373.1"
                     /transl_table=11
                     /translation="MTLTGAKIDLRGRDFIALADYTKEELEYLIDLAIELKRKQKAGEV
                     YHPLAGKTLGMIFEKSSTRTRVSFEVGMYQLGGHALFLSKNDLQLGRGETISDTAQVMS
                     RYLDGIMIRTFAHRTVIDLARSATIPVINGLTDMSHPCQVLADYQTILEHKGRLAGLKV
                     AYIGDGNNMAHSLMMGAAKLGVHMAVASPEGYAPDANVIAQCKEQAELTGAELVVTQDP
                     AEAVAAADVIYTDVWASMGFEEEQKVREQAFKSFQVNEDLVRYAKPDYIFMHCLPAHRG
                     EEVSADVIDGGNSVIFDEAENRLHAQKAILAALM"
     gene            1544..2800
                     /locus_tag="L3476_RS23785"
                     /old_locus_tag="L3476_23730"
     CDS             1544..2800
                     /EC_number="6.3.4.5"
                     /GO_function="GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1291: argininosuccinate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674749.1"
                     /locus_tag="L3476_RS23785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23730"
                     /product="argininosuccinate synthase"
                     /protein_id="WP_272826352.1"
                     /transl_table=11
                     /translation="MEKIKIVLAYSGGLDTSVILTWLKETYDAEIIAFTADVGQKEELD
                     GLEAKAIATGASKVYIDDLQEEFARDFIYPMFQAGALYEGQYLLGTSIARPLIAKRMVE
                     IARKEGAKFIAHGATGKGNDQVRFELAVASLAPDIEVIAPWRSEEFRSQFPGRAEMIAY
                     AEKHGIPVQASAAKPYSTDRNLLHISFESGMLEDPWFDAAADSNKEMYVLSVAPEDAPD
                     EAEYVELTFDQGNCVAVNGERMTPLQVMNKLNELGGKHGIGRVDMVENRFVGMKSRGVY
                     ETPGGTILFTAHRKMESLTMDREVMHLRDSLIPKYSSIVYNGFWFAPERLAIQALVDES
                     QKHVTGTVRLKLYKGNVLGAGVQSPLSLYNPDIATMEADPTQAYDQNDATGFIHLNALR
                     LKVASGVHGASVNGAKLEQ"
     gene            2925..4337
                     /gene="argH"
                     /locus_tag="L3476_RS23790"
                     /old_locus_tag="L3476_23735"
     CDS             2925..4337
                     /EC_number="4.3.2.1"
                     /GO_function="GO:0004056 - argininosuccinate lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674748.1"
                     /locus_tag="L3476_RS23790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23735"
                     /product="argininosuccinate lyase"
                     /protein_id="WP_272826353.1"
                     /transl_table=11
                     /translation="MSKLWGGRFTKQTNELVEQYTASISFDKLMAEEDIQGSLAHVTML
                     GRCGILPQDDVETIKNGLNQVLNRIQNGEMEYSVSDEDIHMNIEKALIEIVGPVGGKLH
                     TGRSRNDQVATDMHLYLRKHVVSFVGLLADLQNALIKQAKENIGTIVPGYTHLQRAQPI
                     LFAHHLMAYVSMFERDIERLIDSYKRINVLPLGAGALAGTTFAIDRHLVAEQLGFDRVY
                     ENSLDAVSDRDFIVEFLSNASLIMMHLSRLCEEMVLWSSTEFQFIELDDAFCTGSSIMP
                     QKKNPDVAELVRGKTGRVYGHLVGMLTVLKALPLAYNKDMQEDKEGMFDTVETLDGALR
                     LFAPMIGTMKVNRGRMADAVRQDFSNATDIADFLVNKGLPFRQAHEVIGKTVLYCIERN
                     KFLLDLTLEEFQQFSPLFDERIYTVLQPENVVNARNVYGGTATGQVQAAIARAEQAAAK
                     TAAWVQEKQPNA"
     gene            complement(4689..6038)
                     /locus_tag="L3476_RS23795"
                     /old_locus_tag="L3476_23740"
     CDS             complement(4689..6038)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="L3476_RS23795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23740"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_272826354.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.9e-43, bitscore:
                     145.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCLYLLLGAQAGETTILFKPDVSLEQKQEFLAQNQFDLLYEIPE
                     VNLVTVNMEEAQIVELERHPLIEALNPATTIKKPEITTIQPITFQPAQRLQALMSPISL
                     LWDYQWDMKAVTSDGQSYSLHTPSTRTVIGIIDSGIDTSHPDLQHSIVEGSKNLVPAGG
                     HNGTEPEEQGKLDDIEDKLGHGTGVAGQIAANGMLKGAAPGIGIKAYRVFGTKAAKTSW
                     VIKAIVEAANDDVDVINLSIGEYMLVSGQFSNGANDSAEYNAYKRAINYAYEKGSVVVA
                     SVGNDGVHISDNQQMIDVLNSKLNHITVVEGKVLDMPGHLQNVVAVGSTGPTKELSLFS
                     NYDQGFLNVLAPGGDFRYLYQYGQDQWTEEAWFEKELILTTWLEGGYNYDAGTSFAAPK
                     VSAAVALMIDKYGWKDDPEKVMRHLKNYSTYEPALTDNYRHLNIVNLLTH"
     gene            complement(6072..8210)
                     /locus_tag="L3476_RS23800"
                     /old_locus_tag="L3476_23745"
     CDS             complement(6072..8210)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="L3476_RS23800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23745"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_143802369.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.7e-40, bitscore:
                     134.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIRKRVPFIQQMEYSECGLACLAMLLNYYRHHTDLNQLREEYPA
                     PRGGYSLFNLVEIAHNKHFETEAFRTDTGHLKQLHLPAIIHWEGKHFILLEKIHARSYT
                     IVDPASGRQRITEEDFLRKFTGYIVTLKPSSAFETKKATTSGLLLNYLKKYKWMLLSIL
                     LFTLGLQAVMVSIPLFTKWFIDQVVATKDASFLSQTGFMLLLMLITYIFINGMRSLIIA
                     FVQTKLDRAIMDDFMDTLLHLPFPFFDNRSNGDILFRANSNIYIREILSTTLITLFIDL
                     LLLITYSAMMIKFSLQLSLVLICTSAVLGLTLFLNSKVVRKMVDNNIRDKIQVQSTVTE
                     MVYNTLDIKVLGIEDRLFGKWKKKYEHQLHSTQKLNIWGSLIQTVTSAIQVILPLFILW
                     LGAFMVLRGDITMGTLLAFSSIAGSFITPVISISNNYTELVSLKSYFSRIQDVLKTKKE
                     QEQPDKLLAPEQLKGKIEFRNVSFKYNRFNEEILKNISFIIHPGESAAIVGHSGSGKST
                     IAKLLLGLNKPASGQILIDDIPIEQYNLVKLRALMGSVLQEAQLFNGTIRENIRMSSEA
                     TDEQVIHAAQKAYIYNEIMSTPLGFDTIVTESGANFSGGQRQRLLMARALVSTPKVLIL
                     DEATSSLDNISELYIKKSISKQPCTKLIIAHRLDTIQDADKILLLHNGQIIEEGDHTSL
                     IHQQGHYYDLYVKKGEVV"
     gene            complement(8207..9283)
                     /locus_tag="L3476_RS23805"
                     /old_locus_tag="L3476_23750"
     CDS             complement(8207..9283)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS23805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_23750"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_272826355.1"
                     /transl_table=11
                     /translation="MLKFKQFSLHPFTITIIYPLILFFLFLWTKEDTFFLVSTCFVLGF
                     ACITIHELGHVFAGYVVGSKLHFMSAGPILLLPGKQAPLRVALNSDLYMMCGMASSYIP
                     SNYLSNKVLQKKLIPAYLGGPLANLFAIVTGFLVRLMPIDNDWLWDATSYFIILNMAIF
                     IGTAFPFSSYTDGGKILELIRGRNMESYRLWNQYLNPDFTLTAPAVNACEQQLDETPQL
                     SKSYHLGIMLIQYHMQNRNYERSLHIIDQLTSKLTKGDGPIMENLISFYRGLFLWASKS
                     DIDEDTLARLKNINYTYGRSFCYLAEAMIHYAEGHQTDNRQKLLQHSKQWLYKIMDHRQ
                     EYILTYAIDSIQKNEMCA"
     gene            complement(9270..9983)
                     /locus_tag="L3476_RS23810"
                     /old_locus_tag="L3476_23755"
     CDS             complement(9270..9983)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014573.4"
                     /locus_tag="L3476_RS23810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23755"
                     /product="flavodoxin family protein"
                     /protein_id="WP_143802367.1"
                     /transl_table=11
                     /translation="MKNIFVYIGSRNKDSRLFRYTYQIIDFVRNHCNAVGNIDIYSPLN
                     CNLHPSTGCKNCFQKGFCPNEESPSDDGELIKTKIEQADIVILASPVYSHNVSSDMKVL
                     IDRLSYWAHIFKLAGKSGVIVTTAESNGAQFVADYLTKIMTYMGASIEHIVNFVNSEQD
                     LAELYAEEAAHKIIEICDDSYHVTPTSQQELTFQTLKLILLDYPRDHFEYRYWKDHGLF
                     DCQSYEELVDKYVKV"
     gene            complement(10001..13054)
                     /locus_tag="L3476_RS23815"
                     /old_locus_tag="L3476_23760"
     CDS             complement(10001..13054)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="L3476_RS23815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23760"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_272826356.1"
                     /sec_met_domain="DUF4135 (E-value: 6.8e-96, bitscore:
                     320.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.9e-50, bitscore:
                     168.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHNIFKSLTIAERYELLAPLNLQEDPQSINHWRSDMSIISDKTF
                     EHMLYINHYNKETFSHAVQYAPEAKNIEKYRNKAIESQWFIVYRQAMALMEDSSFHEDR
                     KNDLHDSLRPFIRYSRKIIHDFLKEHEHIHLEIEVFNRILIQLEQTLMDMAHKSLVLEL
                     NLCRENGRLEGDTSEERFLSFVRKFDEKDFVDEFYNKYIVLTRLLSTVTMFFTRNIQTL
                     LSRIFENQQELITTFDITDFTIQSIKLGEGDTHQQGNTVSVITFADNSKIVYKPKRLQI
                     NLAFNHLLDWLNAHSILQLRGVTTLVYDEYAYEEFVAYKPCNNLEEVEAYYQRFGQLMA
                     VIQLLNGTDIHMENLISHGEYPVIIDLETLIQQPMPVERQSSHHLKEITDTLFHHVTRT
                     LFLPTNGVKIEDPIKIDLSALSGRKKKFEFKVLQPVNQGTDQLKYDYQNFELEGANNLP
                     FIENDDLIIDYKLYREQIIQGFRDVCEIFLQNKEELIQDGSVLYHFNGIYTRCLFRDTS
                     QYANIMMHMQHPEMLMDMLDREKALENMWAFPYTDKHLIQAEAADMMHNDIPVFFSRTD
                     RPSIIPSSNEEISGFYTISSFEYFIKSINNLSETEINKQISIIHLHYGGFSEYRKQENE
                     SLTQSINLIKDLPYMTTDFVHEAELIAEEIMRRAFTREMTSWIIPYETELDVWSLIPIR
                     EDFYNGIGGIYLLFHFLYQKTQNEKYVHFANDILEHYPVEQATNFELGLSGYPGLLYAF
                     SLIDDYGTNKLKITKMINKYCEQFEKLADKEMEEKLQFDYVNGFSSLINALLRLYHKRK
                     DSKFIQLAMKLANHLTAKLAHLDQLDTGFAHGVTGYALTLFRMGKVTQLPQYTNKAKAL
                     MEYANEHIDDTNKAMSWCHGFIGEGIARMEMEPWLGELDDAIIQAAILDKTKNSQLLAN
                     DCMCHGNMGITELFLTHYKLTKDTDSIELARTIASHVVNLKQQYNRKYKLMDITEYPDV
                     TLFTGLAGIAYQLLRIADPEGVPSILTI"
     misc_feature    complement(13088..13101)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.57"
                     /tool="antismash"
     gene            complement(13137..13334)
                     /locus_tag="L3476_RS23820"
                     /old_locus_tag="L3476_23765"
     CDS             complement(13137..13334)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03893.1"
                     /locus_tag="L3476_RS23820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23765"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_240927325.1"
                     /transl_table=11
                     /translation="MNNQLEHSPVGKSLKSLSEEEMASIFGGDGMDVEVRSTLICGVGA
                     SFIGSYLASAAFKCGKKNKK"
     CDS_motif       complement(13251..13334)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNQLEHSPVGKSLKSLSEEEMASIFGG"
                     /locus_tag="L3476_RS23820_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13137..13250)
                     /prepeptide="core"
                     /locus_tag="L3476_RS23820_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.60"
                     /molecular_weight="3762.4"
                     /monoisotopic_mass="3760.0"
                     /core_sequence="DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNQLEHSPVGKSLKSLSEEEMASIFGG"
                     /leader_location="[13250:13334](-)"
                     /alternative_weights="3780.4"
                     /alternative_weights="3798.4"
                     /alternative_weights="3816.4"
     gene            complement(13347..13571)
                     /locus_tag="L3476_RS23825"
                     /old_locus_tag="L3476_23770"
     CDS             complement(13347..13571)
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064151.1"
                     /locus_tag="L3476_RS23825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23770"
                     /product="mersacidin family lantibiotic"
                     /protein_id="WP_272826357.1"
                     /transl_table=11
                     /translation="MTQEEIKLMNHSCGSGLKSLSREEMQNIYGASDVEPRGTPATIVS
                     AVTRSSKPCISAIGSAISGIISHNKDCLG"
     CDS_motif       complement(13479..13571)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTQEEIKLMNHSCGSGLKSLSREEMQNIYGA"
                     /locus_tag="L3476_RS23825_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13347..13478)
                     /prepeptide="core"
                     /locus_tag="L3476_RS23825_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.00"
                     /molecular_weight="4098.6"
                     /monoisotopic_mass="4096.2"
                     /core_sequence="SDVEPRGTPATIVSAVTRSSKPCISAIGSAISGIISHNKDCLG
                     "
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTQEEIKLMNHSCGSGLKSLSREEMQNIYGA"
                     /leader_location="[13478:13571](-)"
                     /alternative_weights="4116.6"
                     /alternative_weights="4134.7"
                     /alternative_weights="4152.7"
                     /alternative_weights="4170.7"
                     /alternative_weights="4188.7"
                     /alternative_weights="4206.7"
                     /alternative_weights="4224.8"
                     /alternative_weights="4242.8"
                     /alternative_weights="4260.8"
     misc_feature    complement(13801..13817)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 21.65"
                     /tool="antismash"
     gene            13865..15040
                     /locus_tag="L3476_RS23830"
                     /old_locus_tag="L3476_23775"
     CDS             13865..15040
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019424746.1"
                     /locus_tag="L3476_RS23830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23775"
                     /product="KamA family radical SAM protein"
                     /protein_id="WP_272826358.1"
                     /transl_table=11
                     /translation="MPMPKYVTDIEKIAQIPETERKRLKQITEKFVFRVNDYYLNLIDW
                     NDPDDPIRKLVIPNTGELQEYGRWDASDEDTNYVVPGCQHKYGTTALLIVSEVCGAYCR
                     YCFRKRLFRNDVKEAMSDVNPGLAYIADHPEINNVLLTGGDSLILATPKLRMILERLRA
                     IPHVQIIRLGSKMPVFNPMRIYEDEALLETIREFSSADKRIYVMAHINHPREITAEAKR
                     GFEALHQAGAIVVNQTPVLRGINDNADVLGELLDKLSWAGVTPYYFFINRPVAGNREFV
                     LPLKDVYRVVEEAKAKTSGLGKRVRLSMSHTSGKIEILAIEDGKAYLKYHQSRDNQYGR
                     FMVLDCPDDAAWFDDLPGNEQFWTPPVKKTEDVVSVNALPDMPQRRTKRDA"
     gene            complement(15374..16810)
                     /locus_tag="L3476_RS23835"
                     /old_locus_tag="L3476_23780"
     CDS             complement(15374..16810)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674745.1"
                     /locus_tag="L3476_RS23835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23780"
                     /product="VanW family protein"
                     /protein_id="WP_143802363.1"
                     /transl_table=11
                     /translation="MKKIHALFIVAASLLLAVTALWGWANSYASQDRLPPEVRLSSWEV
                     GGMSFAAFREELDQRLRQLEATPVEVTFGSSGAAPVKTTLSALGVTYDAKPLLAALKPL
                     QEGSLWERIIARRSFNKEWELQFHWKANVWKERFTPGWETASFGKPVNASREITKDDQV
                     VYTPERQVYRVDRMQLEQLIRAAIPPVWYEGGAIRIEAPLVLTDPPVTVASLKAEGIER
                     KIIEYSTGFAKSEDGRTHNVVSAAQTIDDMILKPGDIFDYDKVIAETEKKYGFKEAPVI
                     YNGKLVPGIGGGICQVSSTLYNAVLRTGLEIVERRNHSLPVSYLPLGLDATFSQGYINF
                     KFKNSTGKHLLIRTETEDGRLTIKFFGTMDKNLSYKMETKTVKVLDPQVKYVKNPNLPA
                     GSEQVLQSGKKGYVVESYRIKLVDGNEVERERIAMDTYQPQPSLIAVNNGSGTVPAKPK
                     TEKEPIVEDGINGPDFKPNT"
     misc_feature    16911..16924
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            complement(16915..17940)
                     /locus_tag="L3476_RS23840"
                     /old_locus_tag="L3476_23785"
     CDS             complement(16915..17940)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019424751.1"
                     /locus_tag="L3476_RS23840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23785"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_165643485.1"
                     /transl_table=11
                     /translation="MRTKKSRHQITRWILGTVIAAILVIPVLLIYIIGQFTPSLNALII
                     KQLFEWKPFASPTNIETITKQVHVVKDIVYDEHGIENSLLDIYYPQNADKALPVIVWIH
                     GGGFVSGNKEQTQEYGMALANEGYVVANINYALAPGQKYPGPVIQANQALIYLQDHIEQ
                     YGGDMSRLFIGGDSAGAQIASQTAAVITNENLAKSMGIQPSVDKNQLKGALLYCGLYNM
                     DRMTQSQSSFILRLGVKSVFWSYTGVKDFATFSRLDEMSTINHVTPEYPPVFLTVGDVD
                     PLAPHSADLIDVLVQNGVEVDSVLFEGTNPELGHEYQFDFTSPHAEKTLGRTFEFLKKH
                     S"
     CDS             18041..18154
                     /gene="allorf_5277560_5277673"
                     /locus_tag="allorf_5277560_5277673"
                     /protein_id="allorf_5277560_5277673"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAFPLVGLPVVRSDIFRMMRNAEPRAGRKKMLNFACS"
     CDS_motif       18041..18145
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAFPLVGLPVVRSDIFRMMRNAEPRAGRKKMLNFA"
                     /locus_tag="allorf_5277560_5277673_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       18146..18154
                     /prepeptide="core"
                     /locus_tag="allorf_5277560_5277673_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.00"
                     /molecular_weight="190.2"
                     /monoisotopic_mass="190.1"
                     /core_sequence="CS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAFPLVGLPVVRSDIFRMMRNAEPRAGRKKMLNFA"
                     /leader_location="[18040:18145](+)"
     gene            18219..18905
                     /gene="ftsE"
                     /locus_tag="L3476_RS23845"
                     /old_locus_tag="L3476_23790"
     CDS             18219..18905
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsE"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007432660.1"
                     /locus_tag="L3476_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23790"
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="WP_087440182.1"
                     /transl_table=11
                     /translation="MIEMQDVWKTYQDGSHALRGVSVRIDKDEFVYVVGPSGAGKSTFM
                     KLIYREEIPTKGQIVVSGFNIGKLKQRKIPFVRRNIGVVFQDFRLLPKLTAYENVAFAM
                     EVIEAPPKVIKRRVPEVLELVGLKHKASSLPAQLSGGEQQRIAIARAIVNNPSVIVADE
                     PTGNLDPENSWGIMKLLEEINYRGTTIVMATHNKDIVNAMRQRVIAIEHGHIVRDEVRG
                     EYGYDF"
     gene            18895..19806
                     /gene="ftsX"
                     /locus_tag="L3476_RS23850"
                     /old_locus_tag="L3476_23795"
     CDS             18895..19806
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006284665.1"
                     /locus_tag="L3476_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23795"
                     /product="permease-like cell division protein FtsX"
                     /protein_id="WP_143802362.1"
                     /transl_table=11
                     /translation="MTFNTLARHLREGSKSLFRNGWMSFASVSSIVISLFILGVFMVLS
                     INVNEITNNIDNQVQIRVFLQLDVTPEETKLLETDIGNMSEVSKVVFISKKEGMKLLEQ
                     QMGEDGKELLAGYSDETNPLPDSFTVDVYEPDHVPIVAKKITMLNETNSVKPIWKVQYG
                     KGTVETLFKVTSTIRNFGLLVVAGLAVTAMFLISNTIKVTIMARQREIGIMKLVGATNS
                     FIRGPFFVEGALLGIIGSVVTIALLFYGYQQLTAHFEFGLMIIRLVPLADIWLLVGGTL
                     LGLGVVIGVWGSTISIRKFLRV"
     gene            19871..21106
                     /locus_tag="L3476_RS23855"
                     /old_locus_tag="L3476_23800"
     CDS             19871..21106
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006284666.1"
                     /locus_tag="L3476_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23800"
                     /product="peptidoglycan DD-metalloendopeptidase family
                     protein"
                     /protein_id="WP_143802361.1"
                     /transl_table=11
                     /translation="MTKQGWKKKWVALIAGGALLLTLVPPAVGEASELDKVNKQLQDLQ
                     RQMQEAEQKQQEADAQKAQAEKLIKKTTKDLNYVVGEIEKKTKEMLDVTLEIDQTEANL
                     EEAAQELEDIKHRIAEREKLLDSRVQLMYTNGAVSYIDVLFSATSFSDFVDRLDSMQTI
                     ASRDKEILSEHKRDKELAVVKKQEIETELKRVKVLYAKLDEAKKNLQLKEKEKKVMIAS
                     YEKQAEDNHGVSEEQERLLMEFAKQRADLIRKKNELNAQRQQRKTGQTSRKVYTYSGGK
                     LGLPLQADYYISSPFGYRTDPITGAKSAFHSGIDMATPGGTPIYAAEDGAVIVAEWYGG
                     YGNCVIIDHGNGLWTLYGHIRPGGIKVQKGDIVKRGDKIAEVGQTGRATGNHLHFEVRL
                     NGEQVNPDTYLK"
     gene            21179..22618
                     /locus_tag="L3476_RS23860"
                     /old_locus_tag="L3476_23805"
     CDS             21179..22618
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674740.1"
                     /locus_tag="L3476_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_23805"
                     /product="S41 family peptidase"
                     /protein_id="WP_143802360.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 4.3e-51, bitscore:
                     171.2, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFKGRTVALLVGAAVLASSVVTLAAVDLPTLASGGQAAATGKGL
                     SPQEMQKINSALGIIENKYVTPVEREKIVNGAVHGMISALQDPYSSYMEAEEAEQFNHS
                     IEGAFTGIGAEVTMENGEVTVVSPIKGSPAEKAGVKPKDVLLSVNGESLAGKTLNEAVE
                     KIRGPKGTKAKIAIKRAGQSEPIELTVVRDEVDFETVYPKMLDDKIGFIEVRQFSMNTF
                     ERFKEELEKLEKQGMKGLVIDVRSNPGGVLDIVQKMTEQFVPKGKTIVQVENRNKERDK
                     YNSQGTSTAVKPYPIAVLTNKGSASASEIMASALKESAGAKLVGEHTFGKGTVQTSYDS
                     GDGGLIKITIAKWLTPDGNWIHEKGIEPDIVVHQPDYYSVAPIPKDKVLKFDMNNADVK
                     NMQLMLDGLGYKPGRTDGYFSKETEAALKSFQSAAGLSATGQADAKTAEKLEADILKAM
                     RDPKNDAQLKKAVETVKQEIR"
     misc_feature    complement(22771..22781)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
ORIGIN
        1 tgctcgccaa ggagcatctg cgcgaagcgt tcggccccgg cagccacggc tcgaccttcg
       61 gcggcaatcc gctcgcgatg tccgcggtca tcggcacgat ggagacgatg atcgaggaga
      121 aggttgccca gcgggcggcg gagcgcggag cgtatctgct gaactcgttg aaggtgaagc
      181 tgagcgacgt gccggtggtg aaggatgtcc gcggcttggg actcattatc ggcatcgaat
      241 gcagcgagcc ggccgcggac atcgtggaag cggcccgcgc cgccggactg ctcgtcatta
      301 cggccggtcc gaacgtcgtc cggctgctgc cgaatctgct cgtaacgccg gaggagatcg
      361 atgaggcggt ctcggttctg catcaagtgc tggaggcgcg ttcgctggcg aaggcgctat
      421 aaatcaaata ccatacccgg agctgccggg cgcttgcggc cgggggcttc gttcattgaa
      481 ggcgcaacag caatacattc gcggcgaatc gccgcgacga gacagatcac ggaggtggct
      541 ttatgacatt gacaggggcg aagattgatt tgcgcggacg cgatttcatc gcgctggctg
      601 attatacgaa ggaagagctg gagtacttaa tcgatttggc gatcgaactg aagcgcaagc
      661 agaaggcggg cgaggtgtac catccgctgg cggggaagac gctcggcatg attttcgaga
      721 agtcgtccac ccggacgcgt gtctccttcg aggtgggcat gtaccagttg ggcggccatg
      781 cgctcttttt gagcaaaaac gatctccagt tagggcgcgg agagacaatc tcggatacgg
      841 cgcaggtgat gtcccgctat ctggacggca tcatgattcg aacgttcgct catcgcacgg
      901 tcattgatct ggcgcgcagc gcgacgattc cggtcatcaa cggactgacc gatatgagcc
      961 atccttgcca ggtgttggcc gactaccaga cgattctcga gcataaaggc cgtctggccg
     1021 gcttgaaagt cgcttatatc ggcgacggca acaatatggc gcactcgctt atgatgggcg
     1081 ccgcgaagct gggcgtccac atggctgtcg cttcgccgga aggctacgcg ccggatgcaa
     1141 atgtgattgc ccaatgcaag gagcaggccg agctaaccgg agcggaactg gttgtcaccc
     1201 aggatcctgc cgaagcggtc gcggctgcgg atgtcattta cacggatgtg tgggccagca
     1261 tgggcttcga ggaagagcag aaggtacggg agcaggcgtt caagagcttc caggtgaacg
     1321 aggatctcgt gcgctatgcg aagccggatt acatcttcat gcattgcctg ccggcgcatc
     1381 gcggcgaaga ggtaagcgcg gacgtcattg acggcggcaa ttcggttata ttcgacgagg
     1441 cggaaaatcg cttgcacgca cagaaggcga tcttggcggc tttgatgtga taacgggata
     1501 acgggatagc agggatagta ttgcaggaac gggggagaca gaagtggaaa agatcaaaat
     1561 cgtattggcg tattcgggcg gcctcgatac gtcggtcatt ttaacctggt taaaagaaac
     1621 ctatgacgcc gaaattatcg cgttcaccgc agatgtgggc cagaaggaag aactggacgg
     1681 cctcgaagcg aaagcgatcg cgactggcgc atccaaagta tatatcgacg atctccagga
     1741 ggagttcgcc cgcgatttca tctatccgat gttccaggcg ggcgccctgt acgaaggcca
     1801 atatttgctc ggcacgagca tcgcgcggcc gctgattgcg aagcgcatgg tcgagatcgc
     1861 ccgcaaggaa ggggccaagt tcattgcgca cggcgcgacg ggcaaaggca atgatcaggt
     1921 gcgcttcgag ctggctgtcg cgtcgctggc gccggacatc gaagtgatcg ccccatggcg
     1981 ctccgaagag ttccggtccc aattcccggg ccgcgccgag atgatcgctt atgcggagaa
     2041 gcatggcatt ccggtgcagg catcggcggc gaagccgtac tcgaccgacc gcaacctgct
     2101 tcatatcagc ttcgagagcg gcatgctgga ggatccgtgg ttcgacgcgg ctgccgacag
     2161 caacaaggaa atgtacgtgc tgagcgtggc gccggaagat gcgccagacg aagccgagta
     2221 cgtcgaattg acgttcgatc aggggaactg cgtcgcggtc aacggcgagc gtatgacgcc
     2281 gctgcaggtg atgaacaagc tgaatgagct tggcggcaag cacggcatcg gccgcgtcga
     2341 catggtcgag aaccgcttcg tcggcatgaa gagccggggc gtgtacgaga cgccgggcgg
     2401 cacgattctg ttcactgcac accggaaaat ggagtcgctc acgatggacc gcgaagtgat
     2461 gcatctgcgt gactcgctca ttccgaagta tagctcgatc gtgtataacg gcttctggtt
     2521 cgcgccggaa cgccttgcga ttcaagcgct cgtggacgag agccagaagc atgtgacagg
     2581 caccgttcgc ctgaagctgt acaagggcaa tgtcctcggt gccggggtac agagcccgtt
     2641 gagcctgtac aacccggata tcgcaacgat ggaagccgat ccgacccagg cttacgatca
     2701 gaatgatgcg accggcttca ttcatctgaa cgcgctgcgg ctgaaggtcg catccggcgt
     2761 ccatggagcc agcgtgaacg gggcgaagct ggagcaatag acggcacgga acaggcaggc
     2821 ggaggctcgg gagctgcgca aggcagttac gcacggcagt ccgccgcttg ccgcaggcac
     2881 gggttgcggg tctgcaacgc aagcaaggtg gagggggtta cagggtgagc aaattatggg
     2941 gcggccggtt cacgaagcag acgaacgagc tggtggaaca atatacggcc tcgatctcat
     3001 ttgacaaatt gatggcagaa gaagacattc agggcagcct cgcgcatgtc actatgctag
     3061 gccgctgcgg aattctaccg caggacgatg tcgagactat taagaacgga ttgaatcaag
     3121 tcttgaaccg gattcagaac ggcgagatgg aatattccgt atctgatgaa gatatccata
     3181 tgaatatcga aaaggcgctg atagaaatcg tcggcccggt cggcgggaag ctgcatacgg
     3241 gacgaagccg caacgatcag gtggcgaccg atatgcatct ctacttgcgc aagcatgtcg
     3301 tctccttcgt cggcctgctg gctgacctgc agaacgcact tatcaagcag gccaaggaaa
     3361 atatcggcac gatcgtgccg ggatacaccc atttgcagcg ggcgcagccg atcctgttcg
     3421 cccatcatct gatggcgtac gtatccatgt tcgagcgcga tatcgagcgc cttatcgaca
     3481 gctacaagcg gatcaatgtt ttgccgctcg gcgccggcgc cttggcggga acgaccttcg
     3541 ccatcgaccg gcatctggtc gccgagcagc tcggcttcga ccgcgtgtac gagaacagcc
     3601 tcgatgcggt gagcgaccgc gatttcatcg tcgagttcct ctcgaacgcg tcgctcatta
     3661 tgatgcacct gtcccggctg tgcgaggaga tggtgctctg gtcgagtacc gagttccaat
     3721 tcatcgagct ggacgacgcg ttctgcacgg gttccagtat tatgccgcag aagaaaaatc
     3781 cggatgtggc tgaactggtg cggggcaaga ctggacgcgt gtacggtcat ctcgtcggca
     3841 tgctgaccgt gctcaaggcg ctgccgctcg cgtacaacaa agacatgcag gaagacaagg
     3901 aaggcatgtt cgatacggtg gagacgctcg atggagcgct gcgcctgttc gcgccgatga
     3961 tcggcacgat gaaggtcaac cgcggccgga tggccgacgc ggtccgccag gacttctcca
     4021 acgcgaccga catcgccgac ttcctcgtga acaaaggctt gccgttccgg caggcgcatg
     4081 aagtgatcgg caagacggtg ctctactgca tcgagcggaa caagttcttg ctcgatctga
     4141 ccctggaaga attccagcaa ttctccccgc tgttcgacga gcgcatctat acggtgcttc
     4201 agccggagaa cgtggtcaac gcccgcaacg tatacggcgg caccgcgacc ggtcaggtgc
     4261 aggccgcgat cgcccgcgcc gagcaagcag cggcgaagac ggcggcctgg gtgcaggaga
     4321 agcagccgaa tgcataaccg ttccatttcg gatacatcgg gttcatgaaa atgggccttg
     4381 tccgtaatac cgctgagcat gcgttaatag cgtcccgtga ggcgttgacg catgccaagg
     4441 taattctaga ggaccccgcc tgatgcggca gggtcctttt tttcgatggg cacacaggcc
     4501 gcttgttttt aggttgttat ctgtcctttt gctgcgaaaa gtccggaggc cccctctccc
     4561 cgtcgttcag aagtacgttc tggtgctgcg aattgcttct ttccttccgc accggtaatg
     4621 aagtcttcct tattggctgg aaggttatgc ggggaagaac aggtgctaat tgtattaggt
     4681 tgaaccgatt aatgcgtgag cagattaacg atatttagat ggcgatagtt atcggttaag
     4741 gccggctcgt aagtagaata gttttttaaa tgcctcatca ccttttcagg atcatccttc
     4801 caaccgtatt tatctatcat caatgctaca gcggcagaaa cctttggtgc ggcaaatgac
     4861 gttccggcat cataattgta cccgccttca agccaagttg tgagtatcag ctctttttca
     4921 aaccatgctt cctctgtcca ttggtcttgt ccatattgat acaagtatct gaaatcccct
     4981 cctggcgcaa gcacatttag gaagccttga tcatagttgc tgaataagga cagctccttt
     5041 gttggtcctg ttgaaccaac ggccacgaca ttttgaagat gtccgggcat atccagcact
     5101 tttccttcga ccacggtgat atgattcagc ttgctattta atacatctat catttgctga
     5161 ttgtctgata tatgtacacc gtcatttcca actgaggcga caacaacgct gcctttttca
     5221 taggcataat ttatagcacg cttataagcg ttatattcgg ccgaatcatt agctccattg
     5281 ctaaattggc cgctgacgag catatattca cctatgctta agttgatgac atctacatca
     5341 tcgttagccg cttcaacaat tgctttaatc acccagcttg tttttgccgc tttggttccg
     5401 aatactcggt aagctttaat accaataccc ggggcagcgc ctttaagcat accatttgct
     5461 gcaatttgcc ccgccacgcc tgtaccatgt cctaatttat cctcaatatc atcaagtttc
     5521 ccttgctctt ccggctctgt tccattatgt ccgcctgcgg gaactaaatt tttcgatccc
     5581 tctacaatac tatgctgtaa atctggatgg gaggtatcaa tccctgaatc aataatgcca
     5641 atcactgttc tcgttgaagg tgtatgcaag gaatagcttt gaccgtctga ggtcactgcc
     5701 ttcatatccc attgataatc ccataacaat gaaataggac tcattagagc ttgaagtctt
     5761 tgcgcaggct gaaaggtaat aggttgaatt gtggttatct ccggtttttt tatggtggtt
     5821 gccggattta aagcttcaat gagagggtgc cgctctagct ccacgatttg tgcttcttcc
     5881 atgtttaccg tgacgagatt tacctctgga atttcataga gcagatcaaa ttgattttgg
     5941 gctaaaaatt cttgcttttg ctctagtgaa acgtctggtt tgaataaaat agtcgtttcg
     6001 ccagcttggg ctccgagaag taaatataaa cagtccaaat aacataaata aacaagagta
     6061 catcagtttc ttcatacaac ctctcctttc tttacataca aatcataata atgaccttgc
     6121 tgatgaatga ggctggtatg atcgccttct tcgataattt gaccgttatg caggagcaga
     6181 attttatccg catcttgaat cgtatccagt cgatgggcaa tgatgagctt ggtgcacggc
     6241 tgtttgctga tgcttttttt aatatacaat tcagatatgt tatccaagct gcttgttgct
     6301 tcatccaata taagtacctt tggcgtggac accaatgctc tagccataag taaacgttgg
     6361 cgttgtccac ccgaaaagtt agctccggat tctgtaacaa tcgtatcgaa gcctaatggt
     6421 gtactcatga tttcattgta aatataagcc ttctgtgcag catgaataac ctgctcatca
     6481 gttgcttcag agctcattcg aatattttct ctgatcgttc cgttaaacag ttgggcttct
     6541 tgaagcactg aacccatcaa ggctctaagc ttaactaggt tatattgttc aatcggaata
     6601 tcatctatca gaatttggcc tgaggcgggt ttgttaagcc ctaaaagcag cttggcaatg
     6661 gtgcttttcc ctgaaccaga gtgacctaca atcgctgcac tttccccggg atgaataata
     6721 aaagaaatgt ttttaagtat ttcttcatta aaacgattgt acttaaatga tacattccgg
     6781 aactcaattt ttcccttcaa ttgctcaggg gcgagcagct tatcgggttg ctcttgttct
     6841 tttttagtct tcaacacatc ttgaatacgt gagaaataag actttaacga cacaagttct
     6901 gtatagttat tgctgatcga gatgacaggg gtgataaaag aacctgcaat ggagctgaag
     6961 gcaagtaacg tccccatcgt aatatcgcct cgaagcacca taaaagcacc aagccataat
     7021 atgaaaagcg ggagaatcac ttggattgca gaggtgactg tctgaattaa ggacccccaa
     7081 atattaagct tttgtgtgct gtgaagctgg tgctcatatt tctttttcca tttaccaaac
     7141 agcctgtcct caatacctaa aaccttaata tccaacgtat tatagaccat ttccgtgacg
     7201 gtagattgaa cttgaatttt atcgcgtata ttgttatcca ccatctttct aacgaccttg
     7261 gaattgagga acaatgtaag tccaagtaca gcgcttgtac aaataagtac cagactaagc
     7321 tgtaatgaaa acttgatcat cattgcggaa taggtaatta acaacaataa gtcaataaat
     7381 aacgtaatta aggtcgttga caaaatttcc cgaatataaa tatttgaatt tgccctaaac
     7441 aaaatgtcac cgttactccg attgtcgaag aaagggaagg gaagatgcag caaagtatcc
     7501 ataaagtcat ccatgatagc gcgatccagc ttggtctgga caaaagcgat aatgagactc
     7561 cgcataccgt taatgaaaat atacgtaata agcatgagca acagcataaa tcccgtttgg
     7621 cttagaaagc ttgcatcttt agtcgctacc acctgatcaa taaaccactt cgtgaataaa
     7681 ggaatgctta ccataacggc ttgcagacct aatgtaaata gaagaataga taggagcatc
     7741 catttatatt tttttaaata atttaaaaga agaccgctcg ttgtcgcttt ttttgtttca
     7801 aaagcggaag agggcttcag cgtcacaata taacctgtga acttgcgcaa aaaatcctcc
     7861 tctgtgatgc gttggcgccc gctggccgga tctacgatgg tatagctgcg agcatggatt
     7921 ttttccaaca aaataaaatg cttgccttcc cagtggatga tcgccggcag atgaagttgt
     7981 ttcaggtgcc cggtatccgt tcggaacgct tctgtctcga aatgcttgtt gtgagctatt
     8041 tctaccaaat tgaacagaga gtacccgcct ctaggagcag gatactcttc ccttaattga
     8101 ttgaggtctg tatgatgacg ataataattc aaaagcatgg ccagacaagc taaaccacat
     8161 tcactatatt ccatctgttg gataaaaggc actctttttc gtatcgtcat gcgcacatct
     8221 catttttttg aatagaatca attgcatagg taagaatgta ttcttggcga tgatccataa
     8281 tcttataaag ccattgtttt gaatgctgta agagcttctg tcggttgtct gtttggtgtc
     8341 cttcggcata atgaatcatt gcttccgcca gatagcaaaa agaacggcca taggtataat
     8401 taatattttt aagccgcgct agagtgtctt catcaatgtc tgatttagat gcccatagga
     8461 ataagccgcg ataaaaagaa atcagatttt ccataatcgg accatctcct tttgtaagct
     8521 tactggtcag ttgatcaata atatgcaagc tacgctcata attacgattt tgcatgtggt
     8581 attgtatgag catgatgcct aggtgatagc ttttggaaag ctggggtgtc tcatcaagct
     8641 gctgctcgca agcattgacc gctggagcag ttaatgtaaa atccggattc agatactggt
     8701 tccacaaacg ataagactcc atatttcgtc cacgaatcag ttccaatatt ttcccgccat
     8761 ctgtataact actaaaagga aacgctgtac caataaatat tgccatattc agaatgatga
     8821 aataactcgt tgcatcccat aaccaatcgt tgtcaattgg cattaatctg acgaggaaac
     8881 ctgtcacaat ggcaaacaaa ttagcaagcg gaccacccaa ataagcagga atcagttttt
     8941 tttgcagtac tttatttgat aaatagttcg aagggatata gctgcttgcc atgccacaca
     9001 tcatatataa atcggagttt aaagcaactc tcaatggggc ctgcttgccc ggcaagagta
     9061 gaatcggacc tgctgacatg aaatgaagct ttgatcccac tacataaccg gcaaaaacat
     9121 gacctaactc gtgaattgta atacatgcaa aacctaatac aaaacatgta gatacaagaa
     9181 aaaaggtgtc ttccttcgtc cacaaaaaaa gaaaaaataa aataagcgga taaatgatag
     9241 taatcgtaaa aggatgtaag gaaaactgct taaactttaa catatttgtc tacaagctcc
     9301 tcgtaagatt ggcaatcgaa taagccgtga tccttccaat aacgatactc aaaatggtca
     9361 cgcgggtagt caagcaggat tagcttcaaa gtttggaacg taagttcctg ctgacttgtc
     9421 ggtgtaacat gatagctatc atcacaaatt tctataattt tgtgtgcggc ttcttccgcg
     9481 tacaactcag caaggtcttg ctcactattt acaaaattaa cgatatgttc aattgaagcg
     9541 cccatataag tcattatttt tgtcagatag tcagctacga actgtgcacc attgctttca
     9601 gccgtagtca cgataacacc agatttaccc gcaagcttga agatgtgtgc ccaataggaa
     9661 aggcggtcaa ttaacacctt catatccgat gacacgttgt gagaatatac agggctagct
     9721 aaaataacaa tgtcagcctg ctctattttt gttttaatca gttctccatc atcgctaggc
     9781 gattcttcat tcgggcaaaa tcctttttgg aagcagtttt tgcatcctgt ggatggatga
     9841 agattacaat taagtggaga gtaaatgtcg atatttccta cagcattaca atggttacgg
     9901 acaaaatcga taatttggta tgtgtaccga aacagtctgg aatccttatt tcgagatccg
     9961 atatatacaa atatgttttt cactctccat caccctccac ttaaatggtt agtattgaag
    10021 ggactccctc tggatcagct atacgcaaca gttggtaagc aattccggct aagcctgtaa
    10081 ataaggttac atccgggtac tcggtaatat ccattaattt atatttgcgg ttatactgct
    10141 gcttcaggtt tacgacatga ctagcaatcg tcctcgcaag ttcgatactg tcggtatcct
    10201 tggttagctt gtagtgggta agaaataatt cggtaatccc catattccca tgacacatgc
    10261 aatcgttggc gaggagctgc gagtttttgg ttttgtctag aatggcggct tgaatgatgg
    10321 catcatctaa ttcgccaagc cacggttcca tctccattct ggcaatgcct tcaccaataa
    10381 agccatgaca ccagctcata gctttattgg tgtcatcaat atgctcatta gcatattcca
    10441 ttagcgcttt tgctttattt gtatattgcg gaagctgtgt gaccttaccc attctgaaca
    10501 gtgttaacgc ataacctgtg acgccatgtg cgaagcctgt atcaagctga tcgaggtgcg
    10561 ctaatttagc agttagatgg ttggctaatt tcatagcaag ttgaatgaat ttactgtctt
    10621 tgcgtttgtg atacaatctt aataaagcat tgattaagct actaaatcca ttaacataat
    10681 cgaactggag tttttcttcc atttccttat cagcaagctt ttcaaattgc tcacaatatt
    10741 tattaatcat tttcgtaatc tttagcttgt tggtgccgta atcgtcaata agtgaaaagg
    10801 catacaataa ccccgggtag ccgcttagcc ctaattcaaa atttgttgct tgttccacag
    10861 gataatgctc taaaatgtca ttcgcgaaat gtacatattt ctcattttgt gtcttctgat
    10921 acaagaagtg aaacagtaaa tagatgcctc cgatgccatt ataaaagtct tctcgaatcg
    10981 gaattagaga ccacacatct agttctgttt cgtatggaat aatccaactg gtcatttctc
    11041 ttgtaaaggc acgcctcatg atctcttcag caataagctc tgcttcatgc acgaaatctg
    11101 tcgtcatgta cggcaagtct ttaattaaat ttatgctttg tgttaatgat tcattttctt
    11161 gtttacgata ttccgagaaa ccgccataat gaagatgaat gatagagatt tgcttgttga
    11221 tttcagtttc gcttaagttg ttgattgatt ttatgaaata ttcaaatgag cttatcgtat
    11281 aaaagcctga aatttcttca ttactgctag gtataatgct tggtctatct gtccggctga
    11341 aaaaaacagg aatatcatta tgcatcatat ctgcagcttc ggcttggatt aagtgcttat
    11401 ctgtatatgg aaaagcccac atattttcaa gcgccttctc acgatcaagc atatccatca
    11461 gcatttcagg gtgctgcatg tgcatcatta tattggcata ttggctcgta tctctaaata
    11521 aacaacgtgt ataaatccca ttgaagtggt agagaacgct gccgtcttga attaattcct
    11581 ctttgttttg caggaaaatc tcacatacat ctctaaaccc ttgaataatt tgctccctgt
    11641 acaatttgta gtcaatgatc agatcatcat tttcgataaa aggaagattg tttgctcctt
    11701 ccagctcgaa attttggtag tcatatttca gttgatctgt tccttgattt acaggctgta
    11761 acaccttaaa ctcaaacttt tttttacggc cacttaaggc gctgagatca attttaattg
    11821 gatcttcgat tttgacgccg ttagtaggca aaaacagcgt acgtgttaca tgatggaaaa
    11881 gcgtatccgt tatctccttt aggtggtgcg aggactgtct ctcaactggc ataggctgct
    11941 ggattaatgt ttctaaatca ataattactg gatattcgcc atgagatata agattttcca
    12001 tatgaatatc tgtaccgttc aacaattgaa taacagccat gagttgtcca aaccgctgat
    12061 aataagcttc tacctcttcc aagttattac acggcttata cgccacaaat tcttcatatg
    12121 catactcatc ataaactaaa gtagtaacac cacggagctg tagtattgaa tgagcattca
    12181 accagtctaa cagatgatta aatgccagat tgatctgcaa tcgtttaggc ttatacacaa
    12241 ttttactgtt gtcggcaaac gtaatgacgg acaccgtatt accttgctgg tgcgtatcgc
    12301 cctcgcctaa tttaatgctt tgtatcgtaa aatcggtaat atcaaatgtt gttatgagct
    12361 cctgttgatt ctcaaagatg cgagacaata gagtttgaat atttcgtgta aaaaacatgg
    12421 taacggtgga taacagacgg gttaacacaa tatatttatt gtaaaattca tcaacaaaat
    12481 ctttctcgtc aaatttgcgg acaaaagata aaaatctttc ttcagatgta tcgccttcta
    12541 atcgtccgtt ttctctgcac agatttaact ccagcactaa cgatttatgt gccatatcca
    12601 ttaaagtttg ctctaattgg ataaggattc gattaaatac ttcgatttct aaatgtatat
    12661 gttcgtgctc ttttaagaaa tcgtggatta ttttacgaga atatcgaata aaaggacgca
    12721 agctatcatg taaatcattt ttacggtcct catgaaaaga gctgtcttcc atcaaggcca
    12781 tggcttgccg ataaacaata aaccattggg attcaatagc tttattccga tatttctcga
    12841 tatttttagc ttcaggggca tattgtactg cgtgtgagaa ggtctctttg ttgtaatgat
    12901 ttatgtacag catatgttca aaggttttgt cagagataat agacatgtca gagcgccaat
    12961 ggttgatgct ttgcggatct tcttgcaaat tcagcggtgc taataattcg tagcgctcag
    13021 caatagtcaa agatttgaaa atattgtgta gcatatcttc acctcatagg aagatttatg
    13081 tagcctattg atatggggca atacgatgag tattgcccca tgaatagatt atgcagttat
    13141 ttcttatttt ttttaccgca tttaaaagca gcagatgcca ggtatgagcc aataaagcta
    13201 gcgccaacac cgcaaatcag tgttgatctt acttctacat ccataccatc tccaccaaag
    13261 atggaggcca tttcctcttc ggataggctc tttaagcttt ttccaacagg ggaatgttcc
    13321 aattgattat tcaaggccat ctctccttat cctaaacaat ccttattatg ggaaataata
    13381 ccgctaatag cgcttccgat tgcagaaata caaggcttgg agcttcttgt tacggcacta
    13441 acaatggtag ctggtgttcc tctaggctca acatcggaag ctccataaat attttgcatt
    13501 tcctccctag atagagattt tagtccactt ccgcagctgt gattcatcaa cttgatttcc
    13561 tcttgcgtca tacaaaatcc ctccttcaaa gtaataatct agctttgttt gctagattta
    13621 accatagttt atcatgaaaa gattacgtgt acaaatatgg caaaaccgaa atcagtgctt
    13681 gacaacccgg aggggatacc ggccaaaaga gcatcacccc tcatctagag gaaaatggta
    13741 ccaaatggcg aaacttgaac gtaaatgtta acaagacctt catttgccac catatgttac
    13801 ttgttgtata ataacaggaa ggcgctttca ttggccgata caactttata caggagggat
    13861 gtccatgcct atgccgaagt acgttaccga catcgagaag atcgcgcaga tacccgagac
    13921 ggaaaggaaa aggctgaagc agatcacgga aaagttcgtc tttcgtgtaa atgactatta
    13981 tttgaacctc attgattgga acgaccccga tgaccctatt cggaagctag tgattccgaa
    14041 cacgggtgaa ctgcaggagt acggccgttg ggatgcctcg gatgaggaca ccaactatgt
    14101 cgtccccggg tgccagcaca agtatggcac caccgccttg ttaattgtgt cggaagtatg
    14161 cggcgcttat tgccgatatt gcttccgtaa gcgactcttc cgcaacgatg tcaaagaagc
    14221 catgtctgat gtcaatcccg gcttggccta tattgccgac caccccgaaa tcaacaatgt
    14281 cctgttaacc ggcggggata gcctcatcct cgcgacaccg aagcttagaa tgattctgga
    14341 acgccttcgc gccatcccgc atgtgcaaat cattcgcctg ggatccaaga tgccggtatt
    14401 caatccaatg cgaatctatg aagacgaggc gctgctggag acgatccgcg aattctcctc
    14461 ggcggacaag cgcatctatg tgatggctca tattaaccat ccgcgcgaga ttacggcgga
    14521 agcgaagcgg ggcttcgaag cgctccatca ggccggcgcc atcgtcgtca atcagacgcc
    14581 cgttctccgc ggcatcaatg acaatgccga tgtgctcggc gagctgcttg acaagctgtc
    14641 ctgggcaggc gtaacgcctt attatttctt catcaaccgc ccggtagcgg ggaatcgcga
    14701 gttcgtgctt ccgctgaagg atgtgtatcg cgtggtagag gaagcgaagg cgaagacatc
    14761 cggattaggg aagcgggtcc gcctctcgat gagccatacg tcagggaaga tcgagattct
    14821 ggcaatcgaa gacggcaagg cgtatctgaa atatcatcaa tcccgcgata accaatatgg
    14881 gcgcttcatg gtgctggatt gtccggacga cgcggcttgg ttcgatgatc tgccggggaa
    14941 cgagcagttc tggacgccgc cggtgaagaa gaccgaggac gtcgtgtccg tcaatgcgct
    15001 gcctgatatg ccgcagcgtc gaacgaagag ggatgcgtaa tgcaaagttc cgccctgtcg
    15061 attgtccgac ttggtgttcc cgttgaccgc tccgggttcc ggtgaacagc ctggcctgtc
    15121 catctgcgga aaggccggca acttcggatg attgactaca gggaatggcg gcgaattgca
    15181 attgatcgcc ttgtatccgg atccaacttc attcttatga agaggcggcg ctcaccgcat
    15241 gacggcaggg cgacccataa gaacatcata ctggacaggg aacagccttg gccccatacg
    15301 gccaaggctg ttcgtatgcc gcccatacgt ctgcaaggtc tctgagcggc gttccccgcg
    15361 tcacgggatc caatcaagta ttcggcttga aatcaggccc attgatccca tcctccacaa
    15421 tcggttcctt ctccgtcttc ggcttcgcag gaacggtccc gctgccgttg ttcacggcaa
    15481 tcagggacgg ctgaggctgg taggtatcca tcgcaatgcg ctcgcgctcc acctcattgc
    15541 cgtccaccag tttaatgcgg tacgactcca cgacatatcc tttttttccc gactgcagca
    15601 cctgctcgct gccggcgggc agattcgggt ttttgacgta ctttacttgc ggatccagca
    15661 ccttgacggt tttcgtctcc atcttgtagg agaggttctt atccatcgtg ccgaaaaatt
    15721 tgatcgtcaa gcgcccatct tcggtctcgg tccggataag gaggtgcttg ccggtagagt
    15781 ttttgaactt gaaattgata tacccctggg aaaaggtcgc gtccagcccc agaggcaggt
    15841 acgagactgg caaggaatga ttgcgccgtt cgacgatttc cagtccagtc cggagcacgg
    15901 cattgtaaag cgtgctcgat acttggcaga tgccgccgcc gatgccgggc accaatttgc
    15961 cgttataaat gacaggagct tccttgaagc cgtatttctt ctcggtctcc gcgatcactt
    16021 tgtcataatc gaaaatgtcg ccgggcttca atatcatgtc atcgatcgtt tgggcggccg
    16081 atacgacatt atgcgtgcgc ccgtcctcag acttggcgaa gccggtcgaa tactcgataa
    16141 tcttccgctc gatcccttcc gccttcaggg aggcgaccgt taccggcgga tcggtcagca
    16201 ccaggggggc ttcgatgcgg atggctcctc cttcatacca gaccggagga atggctgccc
    16261 gaatcaactg ctccagctgc atccgatcga cgcggtatac ttgccgctcc ggcgtataga
    16321 cgacctggtc atccttcgta atctcgcgcg aggcattgac cggcttcccg aagcttgccg
    16381 tctcccagcc tggcgtaaac cgttccttcc acacattcgc tttccaatga aactgcagct
    16441 cccactcctt gttgaagctt cttctggcga ttatccgctc ccagagagag ccttcctgca
    16501 acggcttcag cgcggccaag agcggcttcg cgtcataggt taccccgagc gcggacaagg
    16561 tcgtcttgac cggagctgcc ccgctggagc cgaaggtgac ctccaccgga gtcgcttcca
    16621 attgccgcag ccgctgatcc agttcctcgc ggaaggcagc aaaggacatc ccgcccactt
    16681 cccaggaaga gagccggacc tccggcggaa ggcggtcttg cgaagcatag ctgttcgccc
    16741 agccccagag ggcggtaacg gccagcagca gcgatgcggc tacgatgaat agcgcatgta
    16801 tttttttcaa accgattgcc tcctgcatga agaaagtaaa gttcagtctc tctcactata
    16861 tgcgcgggaa gaggcaaact ttacttggaa agcgcagggg cggttaccgg ggcatcagct
    16921 atgctttttc aaaaattcaa atgttctccc taatgttttt tcggcatggg gagaagtaaa
    16981 gtcaaattga tattcatggc ccaattcggg attggtgcct tcaaataata cactatccac
    17041 ttcgacgccg ttctgaacga gaacgtcgat gagatcggcg gaatgcggcg ccaatggatc
    17101 gacgtctccc acggtaagaa agacaggcgg gtattccggc gtgacatggt taatcgtgga
    17161 catctcgtcc agccgggaga aggtggcgaa atctttgact cccgtatagg accaaaaaac
    17221 cgacttcact ccaagccgca gaataaaaga ggactgggac tgagtcattc tatccatatt
    17281 gtaaagaccg cagtataaga gggcgccttt gagctgattt ttatcgacgg agggctgtat
    17341 ccccatcgac tttgccaggt tttcatttgt tatgacggct gcagtttgac tggcgatctg
    17401 ggctcccgcc gaatcgccgc caataaataa ccggctcatg tcgccgccgt attgctcaat
    17461 atggtcctgt aaatatatca gagcttggtt ggcctgaatg acgggccccg gatatttctg
    17521 ccccggagca agagcgtagt tgatattggc tacgacatac ccctcattgg cgagtgccat
    17581 tccatactct tgcgtttgct ctttattccc ggatacgaat ccccctccat gtatccacac
    17641 aatgacgggg agagccttgt cggcgttttg cggatagtag atatcgagga ggctattctc
    17701 tattccgtgc tcatcataca caatatcttt tacgacgtgg acttgcttag tgattgtctc
    17761 gatgttggtg ggcgatgcaa agggcttcca ttcgaagagc tgcttaatga tcagggcgtt
    17821 aagcgaaggc gtaaactgac cgatgatata tatgagcaat acaggaataa ccaagatagc
    17881 cgcgataacg gtgccaagta tccaacgtgt tatttggtga cgtgatttct ttgttctcat
    17941 tcgaatcaac ccttcctttc tcgttgtcgt tgcttgcttg gctagttgac ccgttaatgc
    18001 aagtatggag attgtaacat aaggtgggcg gtcaggaaaa atggcctttc cccttgtagg
    18061 gttgcctgtg gttcgaagcg acattttccg catgatgcgc aatgccgagc ctcgtgcagg
    18121 ccggaaaaag atgttgaatt tcgcttgttc ttagaggaat tggcgtgcgg gtgtcgaata
    18181 tgtagaggct aatcttttat aacgtagggt gtgatgattt gatagaaatg caggatgtgt
    18241 ggaagacata ccaggacggg tcgcatgcat tgcgcggggt ctctgtccga attgacaagg
    18301 atgagttcgt ctatgtggtt ggtccttccg gagcggggaa atcaaccttt atgaagctga
    18361 tatacagaga ggaaattccg acgaaaggac agattgtcgt cagcgggttc aatatcggga
    18421 agctgaagca gcgcaaaatt ccgttcgtgc ggcgcaatat cggcgttgtg ttccaggatt
    18481 tccgtctgct gcccaagctg accgcttatg aaaatgtagc cttcgcgatg gaagtcatcg
    18541 aggctccgcc gaaagtcatt aagcgccggg tgccggaggt gctcgagctg gtcggcttga
    18601 agcataaggc atcgagtctg cctgcccaat tgtctggcgg ggagcagcag cgaatcgcaa
    18661 tcgcccgggc gattgtgaac aatccttcgg ttatcgtcgc ggacgagccg accggcaacc
    18721 tcgaccccga gaactcttgg ggcattatga agctgctgga ggaaatcaat taccgcggaa
    18781 cgaccattgt catggcgacg cacaacaagg acatcgtcaa tgccatgcgt cagcgggtta
    18841 tcgcgattga gcacggacat atcgtgcggg atgaggtacg gggggaatac ggatatgact
    18901 tttaatacgt tggcccgcca tctgagagaa ggcagcaaga gcttattccg caacggatgg
    18961 atgtcattcg cctccgtaag ttcgatcgta atctctctgt tcatactcgg tgtattcatg
    19021 gtactgtcca tcaacgtcaa tgagattacg aataatattg acaatcaagt gcagattcga
    19081 gtcttccttc aactggatgt gacgccggag gagacgaagc tgcttgagac cgatatcggc
    19141 aatatgtccg aggtcagcaa ggtcgtcttc atctcgaaga aggaaggaat gaagctgctg
    19201 gagcagcaaa tgggcgaaga cggcaaggaa ctgctcgccg gctatagcga cgagaccaat
    19261 ccgctgccgg attccttcac ggttgatgtg tacgagccgg atcatgtgcc gatcgtcgcc
    19321 aaaaaaatca caatgcttaa tgagacgaac agcgtcaagc cgatctggaa ggtgcagtac
    19381 ggcaagggca ccgtggagac gctgttcaaa gtcacctcga ccatccgcaa cttcgggctg
    19441 cttgtcgttg ccgggctggc cgttacggcc atgttcctca tttccaatac gattaaggtg
    19501 acgattatgg cgcgccagcg cgagatcggc attatgaagc tggtcggcgc gacgaattca
    19561 ttcattcgcg gaccgttctt cgtggaaggg gctctgctcg gcatcattgg ctcggtggtg
    19621 accatcgcat tgctattcta cgggtatcag cagctgaccg cgcattttga gttcggactg
    19681 atgattatta ggctggttcc cctggcggat atttggctgc tcgtgggcgg aacgctgctt
    19741 ggcctcggcg tcgtcatcgg cgtatggggg agcacgattt cgatacggaa gttcttgagg
    19801 gtttaatccc ttttttcaaa ataggacact cgacgcagat gcaccagatg acaggtaagg
    19861 aggaaccgtg ttgacgaagc aaggatggaa gaagaaatgg gttgccctga tagcaggggg
    19921 cgctcttcta ttgacgctcg tgccgccggc ggttggggaa gcgtcggagc tggataaagt
    19981 gaacaagcag cttcaggacc tgcagcggca gatgcaggaa gcggagcaga agcagcagga
    20041 ggccgacgcg cagaaagcgc aggccgagaa gctgattaag aaaacgacca aggatctgaa
    20101 ttatgtggtc ggcgagatcg agaagaagac gaaggaaatg ctcgatgtga cgctcgaaat
    20161 cgaccagacg gaggcgaatc tggaggaggc ggcccaagag ctggaggata tcaagcaccg
    20221 gattgccgaa cgggagaagc tgctcgattc gcgcgtgcag ctaatgtata cgaacggcgc
    20281 cgtctcttat atcgatgtct tgttcagcgc cacgagcttc tccgatttcg tcgatcggct
    20341 cgattcgatg cagacgatcg cttcccggga caaggaaata ttgagcgagc ataagcgcga
    20401 caaggagctt gccgtcgtca agaagcagga gattgagacg gagctgaagc gggtcaaggt
    20461 gctgtacgcg aagctggatg aagcgaagaa gaacttgcag ctgaaggaaa aagagaaaaa
    20521 ggtcatgatc gcaagctatg agaagcaggc ggaggacaac catggcgtga gcgaggagca
    20581 ggagcgtctt ctgatggaat tcgccaagca gcgcgccgac ctgattcgca aaaagaatga
    20641 gctgaatgcg cagcgtcagc agcgaaagac gggccaaacg tcgcggaaag tatatacgta
    20701 ctccggcggc aagctcggtc tgccgctgca ggctgactac tacatttctt cgccattcgg
    20761 ttaccgcacg gatccgatca ccggcgccaa aagcgcgttc cacagcggca ttgacatggc
    20821 gaccccgggc gggacgccga tctatgcagc cgaggacgga gcggttatcg tagccgagtg
    20881 gtatggggga tatggtaatt gtgttataat tgatcacggt aacgggctct ggacgctgta
    20941 tggccatatt cgtccgggtg gcatcaaggt tcagaagggc gatatcgtca agcgtggcga
    21001 caaaatcgcg gaagtgggcc agaccggccg cgcgacgggc aaccatcttc atttcgaggt
    21061 gcggctgaac ggcgaacagg tgaatccgga cacttatctc aaataaaatg cactgcaatg
    21121 gcatatacta gtaaagacct aagcatgcgc atatggacaa gacaaaggcg gtgattcaat
    21181 gtcgttcaaa ggacggacgg tcgccttact tgtaggggcg gcagtgctgg cgagcagcgt
    21241 ggtgacgctg gctgcggtgg atttgcccac tctggccagc ggaggacaag cggcggccac
    21301 aggcaaaggc ttgtccccac aggagatgca gaagatcaat tccgctctcg gcattattga
    21361 aaataagtat gtaaccccgg tagaacgcga gaagattgtg aacggggctg tacatggcat
    21421 gatctcggca ctgcaagatc cttactcgtc ttatatggag gcggaggaag ccgaacaatt
    21481 caatcacagc atcgaaggcg cctttacggg catcggcgcg gaagtgacga tggagaacgg
    21541 cgaggtcacg gtcgtatccc cgatcaaggg ctcgcctgcg gagaaggcgg gcgtgaagcc
    21601 gaaggatgtg cttctctctg tcaacggcga gagcctggcc ggcaagacgc tgaatgaagc
    21661 cgtggagaag attcggggcc cgaaaggcac caaggcgaaa atcgcgatca agcgcgcagg
    21721 ccaatccgag ccgattgagc tgacggtcgt ccgcgatgag gtggacttcg agacggtcta
    21781 tccgaagatg ctggatgaca agatcggatt tatcgaggtt cgccagttct cgatgaacac
    21841 gttcgagcgc ttcaaggaag aactcgagaa gctggagaag cagggcatga aggggcttgt
    21901 catcgacgtg cgcagcaacc cgggcggggt gctcgatatc gtgcagaaga tgacggagca
    21961 gttcgttccg aagggcaaga cgatcgttca ggtggagaac cgcaataagg agcgcgacaa
    22021 gtacaactcc caaggaactt ccaccgccgt gaagccgtat ccgatcgcgg tgctgaccaa
    22081 caagggcagc gcgagcgcat ccgagattat ggcgagcgcg ttgaaggaat ccgccggagc
    22141 gaagctggtc ggcgagcata ccttcggcaa aggaacggtc cagacgagtt atgattcggg
    22201 cgacggcggg ctaatcaaga ttacgatcgc gaagtggctc actccagacg gcaattggat
    22261 tcatgaaaaa ggcatcgagc cggatattgt cgttcatcag ccagactatt acagcgtcgc
    22321 gccgattccg aaggacaaag tgctcaagtt cgatatgaac aatgcggacg tgaaaaatat
    22381 gcagcttatg ctggatggtc tcggttataa gccgggccgg acggacggct atttctccaa
    22441 ggagaccgaa gccgcgctga agtcgttcca gagcgccgct ggattgagcg cgaccggcca
    22501 ggcggacgcg aagacggcgg agaagctgga agccgacatt ttgaaggcga tgcgtgatcc
    22561 gaagaatgat gcgcaattga aaaaagcggt agaaacggtg aagcaggaaa ttcgctaagc
    22621 gccgtcgaat agggaaagga aggtcgcaag cttgaacttg ccggccttcc ttttttcagc
    22681 tatatggaaa agtatgagat tgagctatac gtggcttcga ttccccgcag cagcgctgtc
    22741 ctcgcttggg gcaggaccgc gtctctgctt gtgacatggc aagtcgcata ttcgaaaggg
    22801 gcgaatgaag tggacctcct tacggaaatt ggcgttcatt tggcggaagc gctgcttcag
    22861 tggctgctgt cgccttttta ttgggtatcc attctattga ttgcacttat ctatcgcaga
    22921 cagatgctgc tcgagcgaag gctgttcgcg gtgaagatgc atagctggat cgagcatacg
    22981 tggcatgcgt ggctgggcgg tctgctggcg ggtctcgccg tctcggccgc ggcgatcggc
    23041 ctgggcatct cctt
//
