LOCUS       NZ_CP094446            21628 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Paenibacillus thiaminolyticus strain Mbale2 chromosome, complete
            genome.
ACCESSION   NZ_CP094446
VERSION     NZ_CP094446.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6487160)
  AUTHORS   Hehnly,C., Shi,A., Ssentongo,P., Zhang,L., Isaacs,A., Morton,S.U.,
            Streck,N., Erdmann-Gilmore,P., Tolstoy,I., Townsend,R.R.,
            Limbrick,D.D., Paulson,J.N., Ericson,J.E., Galperin,M.Y.,
            Schiff,S.J. and Broach,J.R.
  TITLE     Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of
            Paenibacillus thiaminolyticus
  JOURNAL   mBio 13 (6), e0268822 (2022)
   PUBMED   36374038
REFERENCE   2  (bases 1 to 6487160)
  AUTHORS   Zhang,L. and Hehnly,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2022) Institute for Personalized Medicine,
            Pennsylvania State University College of Medicine, 500 University
            Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-APR-2021
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_P.thiaminolyticus_Mbale2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028554415.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 07:15:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,780
            Genes (coding)                    :: 5,579
            CDSs (with protein)               :: 5,579
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 201
            CDSs (without protein)            :: 201
            Pseudo Genes (ambiguous residues) :: 0 of 201
            Pseudo Genes (frameshifted)       :: 146 of 201
            Pseudo Genes (incomplete)         :: 68 of 201
            Pseudo Genes (internal stop)      :: 17 of 201
            Pseudo Genes (multiple problems)  :: 26 of 201
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:53:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3749941
            Orig. end                         :: 3771569
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094446.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bacteria and source DNA
            available from Schiff/Broach Lab, 500 University Drive Hershey, PA
            17033.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21628
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="12"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21628
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21628
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11628](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11628
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(812..825)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    1102..1115
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.54"
                     /tool="antismash"
     gene            complement(1264..2679)
                     /locus_tag="L3476_RS17090"
                     /old_locus_tag="L3476_17060"
     CDS             complement(1264..2679)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679327.1"
                     /locus_tag="L3476_RS17090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17060"
                     /product="MFS transporter"
                     /protein_id="WP_272825715.1"
                     /transl_table=11
                     /translation="MKTPTVPYKGSDKLIVGIVFGVITFWLFAQSMVNIVPDVQADLGI
                     SLDTLNIAISLTALFSGIFIVVAGGMADRFGRMKLTYIGLILSIIGSLLLILAHGSGML
                     IAGRVIQGLSAACIMPATLALMKTYFEGAERQRALSFWSIGSWGGSGVCSFAGGAIATY
                     MGWRWIFVFSIVFAVLAMLLIKGTPESKVEQSGSKARFDFGGLVMFVITLVTLNLIITR
                     GSSFGWTSPITLSLAAVFLVSMVIFFKIEFRHANGFIDFSLFKNKAYTGATVSNFLLNA
                     AAGTLVVANTYVQIGRGFTAFESGLLSLGYLVCVLVMIRVGEKLLQKHGSRKPMITGSL
                     ITAIGIALMSFTFVPGFLYTLLVFVGFMLFGIGLGMYATPSTDTAVSNAPESKVGIASG
                     IYKMASSLGGSFGVAISASVYGVIAAAGSIELAAMVGLLTNVAFCVVSLLSVIITAPKG
                     SKQENAVLAPAAK"
     gene            complement(2654..3865)
                     /locus_tag="L3476_RS17095"
                     /old_locus_tag="L3476_17065"
     CDS             complement(2654..3865)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679326.1"
                     /locus_tag="L3476_RS17095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17065"
                     /product="M20 family metallopeptidase"
                     /protein_id="WP_272825716.1"
                     /transl_table=11
                     /translation="MKTELFRRLDEKKERIIEIRRYLHAHPELSFQEENTAKYIAEFYT
                     DKPCVVREHVGGNGVVVTIDSGKPGKTLAIRADFDALPITEQTGLPFASQNPGVMHACG
                     HDGHTAYMLVLAETLMEMKDQLEGKVVILHQHAEETPPGGAIHMIQDGCLDGVDHVLGI
                     HVMSTMETGGIFYREGPIQTGRAYFKVKIHGKGGHGSSPHMANDAIVAASEFVCAVQTI
                     VSRRLNPFDVGSITIGSFDGKGSFNVIKDAVELEGDVRAMTEETRSLIEQEIRRILSGL
                     QEMFGITYELEYNNDYPVLINDPAFTEFVVKSLAQSGIPEVTSIERCEPQPPSEDFAYY
                     AQQRPSVFFYVGAMPDHGAYYPHHHPKFEINEDSLQIAAKAMGALVIDYMKEGGRDEDT
                     NSSV"
     gene            complement(4069..6426)
                     /locus_tag="L3476_RS17100"
                     /old_locus_tag="L3476_17070"
     CDS             complement(4069..6426)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679325.1"
                     /locus_tag="L3476_RS17100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17070"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_272825717.1"
                     /transl_table=11
                     /translation="MPNAATNNNYEISMENIRSMPPTSYFGTKILFVISGSLTVNCTAR
                     DYKLQAHDILILNRNDRHEIASQEDNIVIVLSLTAQFFAQHDKSYFSYHFDCFSREMDP
                     GREQMAALLRRYVAEIMIAYSRTGALPNLELQSSLFQMMLLLTRFFKTEAPVSEGSSHD
                     DERIMRIIQEIEQRYDEPITLNEIAQKEYLSVSYLSRYFKKMTGFGFVQYVNLVRLKHS
                     LDELLHSTDPLSHIALKHGFASSKHFNAVFKAAYGMSPAQYRKEHSELQDDVQPAANHA
                     SEPRTVLQSPDILAKLAQYIETGEQISDISEAVFENRLIELDPTRQEEVAVSTHVLFIG
                     QLKELLNENVKEQVLMAQQELRIRYIGIRNLIFGKTLLPEVETDELVATSTPFMNSDLA
                     LQFLQDHHLHLLIRIEYQEISSDENKYFELLDKFIRHSIQIFGRDTVAKWRFLYYEPPA
                     TIASPEELRRIYLRLQALVKSREERVQVGTYLPFSERTGTTTTQHDWQLSHSDVIDFIA
                     YEANPNEVVDFDKSADDDFTETQDYILSATSKLKAYLRKHRMEKSLFLMSWNTLTGNTR
                     YTNGTFFRGALVMRAVLDISREADAIGFWINTEQHEGERRARNISIDGLELFHFFNGKR
                     PAYYAVMFKERLRGRIVAQGKDYVMTEHADGYQLALLNCNNFNPRFSVEELFLRQRKKE
                     MHIRLLGMKPGAYQIRKFQFDRDHGALYSEWGKFNSKHGVDQEIMNYVIHRSTPSLKVI
                     DEQMSADWSFYVYLDMNAIHFYEFRRMFDDMN"
     gene            complement(6596..7000)
                     /locus_tag="L3476_RS17105"
                     /old_locus_tag="L3476_17075"
     CDS             complement(6596..7000)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018756298.1"
                     /locus_tag="L3476_RS17105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17075"
                     /product="DUF1259 domain-containing protein"
                     /protein_id="WP_272825718.1"
                     /transl_table=11
                     /translation="MPNSGSLCAHFSRIIGGQPGFAGGKCVSTINRKRIRATILGKRFS
                     VTSSFSFESLDERTGRALCVGRAAFLEKEVNPFITAIRKQGIKVTSVRNEWLFERPRLI
                     YVNIEAVEKPLVFARKVRRALDAIHEGFKP"
     misc_feature    7085..7094
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.22"
                     /tool="antismash"
     misc_feature    7086..7099
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    7087..7100
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     misc_feature    complement(7088..7101)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    complement(7148..7159)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.42"
                     /tool="antismash"
     gene            7289..7756
                     /locus_tag="L3476_RS17110"
                     /old_locus_tag="L3476_17080"
     CDS             7289..7756
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024676.4"
                     /locus_tag="L3476_RS17110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17080"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_272825719.1"
                     /transl_table=11
                     /translation="MKAIDEVYALYFAMLTLEAYQSTPFHLSVNQIKQIHQMKKVLQFE
                     AHQQHHVSRFLDKILKSILNESTCKIQYVKNDQKKSCHVQFFKISAKFGQWYAAGIELN
                     TNKYRVFRCDRITGIKEEVQETTKKAPCRRTCEGALFGERLPRINRTILFL"
     gene            complement(7745..9343)
                     /locus_tag="L3476_RS17115"
                     /old_locus_tag="L3476_17085"
     CDS             complement(7745..9343)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679321.1"
                     /locus_tag="L3476_RS17115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17085"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_272825720.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.3e-48, bitscore:
                     161.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSSQSADDILMEADSLTESGFTIADSLFGQDAGSFSVQSLDSDV
                     RATAIEKMGLVYLVEYAVEDYKSIDSAKISLEKTLANLGFNVRYVTENRKMYALETATV
                     QDVSPQDIHNNQRWHYEMIKVPQAWEITTGSSSVRIGVLDTGIDSNHPSLKNLVNTSLG
                     SSFVGGTTNDGNGHGTHVAGTIASYGSVSGVMQNATLIPIKVLNDSGSGSLYGVQQGIV
                     YAANIKADVINMSLGGGGYDQGMDEAIQTAVSLGTIVVAAAGNDGRPIISYPAAYSGSI
                     AVGSVTSSRTRSSFSNYGPGLDVMAPGSNIYSTYKNGQYTTLSGTSMSTPHVTGVFGLM
                     RSVNPNLSPAAAGDILRNTAQPAGSSDQYGHGIVDAHAAVLAAGGGDDTQAPSAPDNLI
                     STDITDTSVSLTWSASTGNAGVTAYEVYNGSSLAATVTTTSATVTDLTANTTYTFTVRA
                     IDAAGNQSAASNAVTVTTDSGSSQPSPTTPWDPGMSYKIGDEVTYGGATYQCLQEHISM
                     AGWEPLNVPALWLEK"
     misc_feature    complement(9678..9694)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 21.32"
                     /tool="antismash"
     gene            10001..10150
                     /gene="scfA"
                     /locus_tag="L3476_RS17120"
                     /old_locus_tag="L3476_17090"
     CDS             10001..10150
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016113838.1"
                     /locus_tag="L3476_RS17120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17090"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_076321126.1"
                     /sec_met_domain="TIGR03973 (E-value: 1.4e-22, bitscore:
                     77.7, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.2e-22, bitscore: 78.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVTLSTRKLMDTAKHGGCGACQTSCQSACKTSCGVANQRCEN
                     AMNK"
     aSDomain        10249..10545
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3476_RS17125_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="7.30E-34"
                     /identifier="RREFam024.1"
                     /label="L3476_RS17125"
                     /locus_tag="L3476_RS17125"
                     /protein_end="99"
                     /protein_start="0"
                     /score="106.9"
                     /tool="antismash"
                     /translation="MIHQYQLNGYNIVIDTYSGSVHVVDDLAYEIIALYEHAAPEQILT
                     IMKEKQYSEESIRETISEVEELISNGQLFTEDAYEELSIDLQKRKTYVKALCLN"
     gene            10249..11628
                     /gene="scfB"
                     /locus_tag="L3476_RS17125"
                     /old_locus_tag="L3476_17095"
     CDS             10249..11628
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679203.1"
                     /locus_tag="L3476_RS17125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17095"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_272825721.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.5e-31,
                     bitscore: 106.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 4.1e-74, bitscore:
                     248.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.9e-12, bitscore: 44.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.8e-17, bitscore:
                     61.9, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYQLNGYNIVIDTYSGSVHVVDDLAYEIIALYEHAAPEQILT
                     IMKEKQYSEESIRETISEVEELISNGQLFTEDAYEELSIDLQKRKTYVKALCLNVAHTC
                     NLSCEYCFASQGKYNGDRAIMSLEVGQRAIDYLLEHSGHHRNLDIDFFGGEPLMAWKVV
                     KQIVAYARSKEKEWKKKFRFTFTTNGMLLNDEVTEFLNQEMYNVVLSLDGRKEVHDRLR
                     TTVTGKGSYDSIVPKFQEFIQKRGDQEYYVRGTYTRNNVDFTNDIFHIADLGFDKISME
                     PVICDPREPYALTEKDLPEIYKQYEILAKEMIERSEQGRGFTFYHYMLDLSEGPCIQKR
                     ITGCGSGTEYLAVTPWGELFPCHQFVGDEAYSMGNIWDGITRPELQCQFRESNCYTKPE
                     CKDCWAKLYCSGGCPANALHATGSINGIYEFSCDVFRKRIECSMMAKVAESIRAMEEDG
                     M"
     gene            complement(11771..12859)
                     /locus_tag="L3476_RS17130"
                     /old_locus_tag="L3476_17100"
     CDS             complement(11771..12859)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679200.1"
                     /locus_tag="L3476_RS17130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17100"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_272825722.1"
                     /transl_table=11
                     /translation="MKTFSKIFSITILVIVIVSIVALLLFGRNNHSNLSGSVSDKIDQY
                     LTNEKFQGTVLIAKEGEVLFTKGYGLAATDLPNSPSTLYQIASLSKTFTAVAVMQLAEK
                     ELLNLDNPMSQYFPDFPNGESITIGHLLSHSSGLPDYLKANFEFDYSKEWNPNDIVKTV
                     SDSELEFTPGKSFSYSNTGYVMLGLIVEKVSGQSYANYIEEHIFEPSNMFNSMFTVPAG
                     IPKAEGHVGGKAGPLMHNSAAYAAGDIISTVEDLERFDRALRNNVLISKETSELMSMTH
                     AKKFPYQYGYGWYTQDVMGKKAVGHSGGYPSGFRHYVTRLHDEELTVIVLSNEMTMNSK
                     KINRNLTSIVLQEPIWIWEEKL"
     misc_feature    13187..13201
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.11"
                     /tool="antismash"
     gene            complement(13542..13925)
                     /locus_tag="L3476_RS17135"
                     /old_locus_tag="L3476_17105"
     CDS             complement(13542..13925)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007722957.1"
                     /locus_tag="L3476_RS17135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17105"
                     /product="hypothetical protein"
                     /protein_id="WP_272825723.1"
                     /transl_table=11
                     /translation="MKFYRYVLSIPPLDWECCFLSIEEYKQSFANKYNQNIEYYMQVIG
                     DCQQHLVDVDNLAVVTYKDLCASVHSAELRCPAMIFSIPSGDQRGSALFCIMYKLENDG
                     DTFIYSPIPLVHLEQDQAGEIEL"
     gene            complement(14081..15682)
                     /gene="rlmD"
                     /locus_tag="L3476_RS17140"
                     /old_locus_tag="L3476_17110"
     CDS             complement(14081..15682)
                     /EC_number="2.1.1.190"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rlmD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679190.1"
                     /locus_tag="L3476_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17110"
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="WP_272825724.1"
                     /transl_table=11
                     /translation="MTGKKLGNGAERRKRRGTAAAVRARSVRERSVGAKSAEANSAEAR
                     TAEGSAAKKRGQAGQTSASAPVSKNDEVVLDIIGLTHDGEGVGRVDGFTLFVSGALPGE
                     QVRALVLKVKKQYGYAKVLERLIDSAHRVELEHPANAYGGCQLQHLEYGEQLRWKRQHV
                     VDVLERIGKFQVEHGAETGDADGQPPIKVLPVIGMEHPWRYRNKSQMPIGADPRTGELI
                     GGYFAKASHRIIDTDVSLLQHERNDEAMRAVKRIARKYGIAPYNEETHTGLLRHAIMRV
                     GFRTDEQMITLVTNGEKLPHEAEIVADLVEALPQLTSICQNINTKRTNVIMGDKTRVLW
                     GSEYITDYIGDIAFKISARSFYQVNPVQTEVLYEKAVEYAGLTGNETVIDAYCGIGTIS
                     LFLAQRAKRVLGVEIVEEAIADARRNAELNGVTNAEFAVGPAEDVIPRWKEQGVTPDVI
                     VVDPPRKGCDTALLDTMLAMRPERIVYVSCNPSTLARDVRVLADGGYRVLEVQPVDMFP
                     QTTHVETVALLVRKDN"
     misc_feature    16059..16072
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.1"
                     /tool="antismash"
     gene            complement(16180..16809)
                     /locus_tag="L3476_RS17145"
                     /old_locus_tag="L3476_17115"
     CDS             complement(16180..16809)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012870.4"
                     /locus_tag="L3476_RS17145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17115"
                     /product="DDE-type integrase/transposase/recombinase"
                     /protein_id="WP_272825725.1"
                     /transl_table=11
                     /translation="MDARTSGRRRACLWLQEFGAAPPQTTWIDFKQEKGVPHLQGARNS
                     SETTKENKQTSSQVTGVNQLWQIDIKYGYVIGCQRFFFVLSIIDVFDRVVVGQYRGPVC
                     EAKHVMQTLCRALQERLNPGDSLPTIRTDNEPQFVSKLVGDTFESLEIVHERIPPRSPN
                     MNAYIESFHSLLERDLFSLTEFMTFEVAYEALDRYMDFYNNRRMHG"
     gene            complement(17012..17332)
                     /locus_tag="L3476_RS17150"
                     /old_locus_tag="L3476_17120"
     CDS             complement(17012..17332)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="L3476_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17120"
                     /product="transposase"
                     /protein_id="WP_272825726.1"
                     /transl_table=11
                     /translation="MGKHFSKEIRLQIVKEALAGIKVGTLARMYGVHPETVRVWVRDHR
                     DEISQEEIPAADEHLQELRRLQEVEAKFEQAKKLLGEKELEIEILRELVKKKNPAYLKD
                     LK"
     misc_feature    17290..17302
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    17433..17449
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.97"
                     /tool="antismash"
     misc_feature    complement(17433..17449)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 21.42"
                     /tool="antismash"
     misc_feature    17536..17550
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.32"
                     /tool="antismash"
     gene            complement(18103..19017)
                     /locus_tag="L3476_RS17155"
                     /old_locus_tag="L3476_17125"
     CDS             complement(18103..19017)
                     /EC_number="2.7.1.107"
                     /GO_function="GO:0003951 - NAD+ kinase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006679189.1"
                     /locus_tag="L3476_RS17155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17125"
                     /product="diacylglycerol kinase"
                     /protein_id="WP_272825727.1"
                     /transl_table=11
                     /translation="MIKKARLIYNPTSGREEGKKRLADILHMLDAAGIEATAHATDGAG
                     DATASAADAIDRGYDMIIAAGGDGTLNEVINGMAGKPSRPPLGIIPLGTTNDFARALGI
                     PRHWEDACSIITRQKTRVIDLGQANDTYFINIAGGGSLTGLTYEVPSKLKTMIGQLAYY
                     MKGLEKMTSLRPTELRIEVDGHGVFHEEFMLFLIANTNSVGGFEKLAPGARIDDGLFDV
                     IMLKKCNLAEFIRVAGMALRGDHILDPLIIHVQSKRVTVTSPDTVQLNLDGEYGGLLPG
                     TFQMLPSHLRIFADVPGEQPEQG"
     misc_feature    complement(19094..19108)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.52"
                     /tool="antismash"
     gene            complement(19224..20102)
                     /locus_tag="L3476_RS17160"
                     /old_locus_tag="L3476_17130"
     CDS             complement(19224..20102)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419967.1"
                     /locus_tag="L3476_RS17160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17130"
                     /product="CbiX/SirB N-terminal domain-containing protein"
                     /protein_id="WP_272825728.1"
                     /transl_table=11
                     /translation="MAQAAWPEGVPIASSFLDCVPGRTIQDGIDELEAQGVDAIGVIPL
                     FISGGSTHVDEIAYALGVTSAPLADTKLPPFRLRAQVRYGRPLDGAALFAAACGGDGPG
                     GDGPAGEPEGTVLLHMVEDRLRGLGAGAGDAALLVAHGSRPEPFAGRWHASLRRLARQL
                     VQRSACAAASHALLCCEDIAAAARKLQQALAVLPADAGPGLLAGDRTLAARAALAEAAA
                     RAGLGRRERRVAVVPVFLSTGYFTARVIPERLGDVPALYDGRPLLPHPALVEWLSREGE
                     RLLAGMKAEDG"
     gene            complement(20178..20468)
                     /locus_tag="L3476_RS17165"
                     /old_locus_tag="L3476_17135"
     CDS             complement(20178..20468)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009592310.1"
                     /locus_tag="L3476_RS17165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17135"
                     /product="YerC/YecD family TrpR-related protein"
                     /protein_id="WP_006678246.1"
                     /transl_table=11
                     /translation="MQLKKLNDKSIDQLFEAILTLESLEECYIFFDDLCTVNEIQSLSQ
                     RLEVARMLGKGCTYNQIEAETGASTATISRVKRCLNYGNDGYKMTLERLGR"
     misc_feature    complement(20604..20623)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 21.65"
                     /tool="antismash"
     misc_feature    20747..20760
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            20773..21405
                     /locus_tag="L3476_RS17170"
                     /old_locus_tag="L3476_17140"
     CDS             20773..21405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678245.1"
                     /locus_tag="L3476_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_17140"
                     /product="oligopeptidase"
                     /protein_id="WP_087443072.1"
                     /transl_table=11
                     /translation="MKVPHRNGRPGIPDPVELMSVPRMRGPHAMHSASPLARERAARNQ
                     ARARPAGIRMNTRSFNGPPPGLPAGYPELSGYTPYQEAPIVPFNAVAETPIEVAAQPEK
                     KLLGNFSMGDLKSMIDKLGGIEGIVDTMGKVQKIMSSVQQIMPVAKMFMGTLLPGKGGG
                     KKLSTADGGDDAPRRRRRYSSGSPRSGSGNRRKSTASRTGSAPRRKK"
ORIGIN
        1 caacccataa tacccgcaca ccacttcggc gaccgacttc gcggccacga gcagcccgtc
       61 ttcgtcgata tcgaacttcg gatggtgatt gaagtagacc tcttgcgcat tcttcggctt
      121 gcagccaatg tagaagaagc agcccgggat tttttccaaa tagtacgcaa agtcctcaga
      181 cccggatagc atatcgcctt caaagatggc ggtcaaataa tcgccgactc cctgctccag
      241 ataacgaacg acgttcgcgg tcacttccgg atgattgtag agcggcggat aatcggccgt
      301 ataggttaag gtcgcttgga cgccgaatgt ctcttcaatc cctttgacga tgcgatgaat
      361 ttctttgtcg atcaacgctt gggtgtccgt cgtcatgtaa cgcacatcgc cttcaagctc
      421 gacatagtcc ttgatgacgt taaagcttcc tttgccgtcg aaggagccga tcgtcacgac
      481 gccagtatcg aatggattca agcgccggct aataatcgtc tgcaccgtcg tgacgaagtg
      541 cgcggcagcg acaatcgcgt cattggccat atgcggcgag gagccgtggc cgcccttgcc
      601 ctgaatgccg agcttgaaat agctgcggcc cgccatcgca aagccgctcc ggtacatcac
      661 ttcgccgaca tcccccgtag ggaagacgtg cacgccgaag atatgctcca cgtcatccag
      721 aaggccggac tccacgatgc tcttggcgcc cccggggggc gtttcctccg catgctggtg
      781 aatgatcttg atcgtgccag gaagctcatc cttgagctga atcaagcagt cggccagcac
      841 gagcaagtaa gcggtatgcc cgtcgtggcc gcaggcgtgc ataacgccgg gattttcaga
      901 agcaaaggga agacccgtct cttcctgaat cggaagcgca tcgaaatccg cccgcagcgc
      961 tatcgtcttg cccggcttgc cgccttgaat cgtgacgata atgccgtgcc cgtttccgac
     1021 ttccgtatcc agcttcacct ctttgccttg atagaagccg cgaatatact tcgcggtctg
     1081 ttcctcctgg aaagatagct ccggatgggc atgcagatgt ctgcgaatcg caatgatctc
     1141 atccttgcgt gcatcgagca gcgctaataa ttggtcacgc atgttcatat cctcctgtga
     1201 atctctatat aactctaatc taatcccaaa cctccaagct tccaagctct ctaatcgtca
     1261 ttcttatttt gcagcaggag cgagaactgc attctcttgt ttgctgccct ttggtgccgt
     1321 gataatgact gacagtaagg atacgacaca gaatgcaacg ttcgttaaca gtccgaccat
     1381 ggcggccagt tcgatacttc cggcagcagc gattacccca tacacgcttg cggagatggc
     1441 gacaccgaac gaaccgccga gcgagctcgc cattttatag atcccggacg caataccgac
     1501 cttgctctcc ggcgcattgg agaccgccgt atccgtcgat ggcgtcgcat acatgccaag
     1561 tccgataccg aagagcatga agccgacaaa cacgagcagc gtatagagaa agcctgggac
     1621 aaaggtgaat gacatcaagg caatcccaat cgccgtaata agcgaacccg taatcattgg
     1681 cttgcgcgag ccgtgcttct gcagcagctt ctcgccgaca cgaatcatga cgagaacaca
     1741 caccaagtag ccgagggaca agagcccgga ttcgaaggcg gtaaagccgc gcccgatctg
     1801 aacgtacgta ttcgcgacaa ccaaggtgcc tgctgcggca ttcaataaga agttcgacac
     1861 ggttgccccg gtataggctt tatttttgaa cagggaaaag tcaatgaatc cattcgcatg
     1921 acggaactca attttgaaga aaatgaccat cgacaccagg aacacggcag caagagacaa
     1981 agtaatcggg cttgtccagc cgaaggagga gcctcgcgta atgatcaggt tcaaggtaac
     2041 gagcgtaatc acgaacataa ccaagccgcc gaagtcgaag cgtgccttgc tgcccgattg
     2101 ttcgaccttg ctctccggcg tacccttgat gagcagcatc gcgagcacag cgaacacgat
     2161 ggagaagacg aagatccagc gccagcccat gtacgtggcg atggcgccgc cggcgaagga
     2221 acataccccg gaaccgcccc aagacccgat ggaccagaag cttaacgccc gctgtctctc
     2281 tgctccctcg aagtacgtct tcatcagagc cagcgttgcc ggcatgatgc aggctgcaga
     2341 cagaccttgg ataacccggc ctgcgatcag catcccggaa ccatgcgcaa gaatgagcaa
     2401 taaggaacca ataatactaa gaataagccc aatgtacgtc agcttcattc gtccgaacct
     2461 gtccgccatg ccgccggcaa cgacgataaa aatccccgag aataacgccg tcaagctgat
     2521 ggcgatattc agcgtatcga gagatattcc gagatcagcc tgaacgtcag gaacaatatt
     2581 gaccatggat tgcgcgaaga gccagaaggt gatgaccccg aacacgatcc ctacgataag
     2641 tttatcgctg cctttatacg gaactgttgg tgtcttcatc tcttccgccc tctttcatgt
     2701 agtctataac gagtgcaccc atagctttcg cagcaatctg caaggagtct tcattgatct
     2761 cgaatttagg gtgatgatga gggtaatacg ctccatggtc aggcatcgcg cctacataga
     2821 aaaatacgct tggacgctgt tgcgcgtaat aagcgaaatc ctcggaaggc ggctgcggtt
     2881 cacaccgttc aattgaagtg acctcgggaa tgccgctctg agccagcgac ttcaccacga
     2941 attccgtaaa tgccggatca ttgatgagaa caggatagtc attgttgtat tccagctcat
     3001 acgtgatccc gaacatttct tgaagtccgg ataagatgcg gcgaatttcc tgttcaatca
     3061 agctgcgggt ctcttccgtc atcgctcgaa catcgccttc cagctcgact gcgtctttaa
     3121 tgacattgaa gcttcctttt ccgtcaaaag agccaatcgt aatggagccg acatcaaacg
     3181 gattcaagcg gcggcttacg atcgtttgca cggcgcatac gaattcgctg gcggcaacaa
     3241 tggcgtcatt ggccatatgc ggggaggagc catggccgcc tttgccatga atcttcacct
     3301 tgaagtaggc gcgtcccgtc tggatcggtc cttcacgata gaagattcct cccgtctcca
     3361 tggttgacat gacgtggatg ccgagcacat ggtccacccc atccaggcag ccgtcctgga
     3421 tcatatgaat cgctccgccg ggcggtgttt cttccgcatg ctgatgcaga ataacgacct
     3481 tgccctctaa ctgatccttc atctccatca acgtctcggc aaggacaagc atgtaagccg
     3541 tatgcccatc atgtccgcaa gcgtgcatga cgcccgggtt ctgcgaggca aagggaagtc
     3601 ccgtctgctc cgtgatcgga agcgcgtcga aatccgcgcg gatcgccaag gtcttgcccg
     3661 gcttgccgct atcaatcgtg acaacaaccc cgttgccgcc gacatgctcg cgaacgacac
     3721 agggcttatc tgtatagaat tcagcgatat acttcgcggt gttctcctcc tggaaggaaa
     3781 gctccggatg cgcatgcaga taacgtctaa tctcaatgat gcgttctttt ttctcgtcca
     3841 gtcgtctaaa tagttccgtc ttcatgacct ctgccctcct ataacatgat gcttatcacc
     3901 ggccagtgaa gaaacatgtt ttcatgcctt aattataggg aggaaagcgg ttacaatcgg
     3961 ccctattttt gcgctcccat gtccttcgtt tttgccctct tcttgtatga gcttcaagtt
     4021 cggacaaaac cgaaggggag attttcaccc actttcgtca aatgtgattt agttcatatc
     4081 atcgaacatt ctacggaact cataaaagtg aatcgcgttc atgtccaagt acacataaaa
     4141 ggaccaatca gcgctcatct gctcgtcaat gactttcaag gaaggggttg atctgtggat
     4201 gacataattc ataatctcct gatcgacgcc atgcttgctg ttgaacttcc cccactccga
     4261 atacaatgcc ccgtgatcgc ggtcgaattg gaatttgcga atctgatacg cacctggctt
     4321 catgccgagc aggcgaatat gcatctcctt cttccgctgt cttaggaaca gctcttccac
     4381 cgagaagcga ggattgaagt tattgcagtt caatagcgcg agctggtatc catcggcgtg
     4441 ctccgtcatc acataatctt tcccttgtgc cacaattcgt cctcttaatc gttccttgaa
     4501 catgacagcg taataagcag gtctcttgcc attgaaaaag tgaaacagct ccagcccgtc
     4561 aatgcttata ttccgcgctc ggcgctcccc ctcatgctgc tccgtattga tccagaagcc
     4621 gatcgcgtcg gcctcgcggc ttatatccag caccgccctc atcactaagg caccgcggaa
     4681 aaacgttccg ttcgtatacc tcgtattccc ggtcaacgta ttccaagaca tgagaaacag
     4741 cgatttttcc atgcgatgct tccttaaata agctttcagc ttggaggtcg cggagaggat
     4801 atagtcctgg gtctcggtga aatcatcgtc agccgattta tcgaaatcca cgacttcgtt
     4861 cggattcgct tcgtatgcaa tgaagtcaat cacgtcgctg tggcttaatt gccagtcatg
     4921 ctgtgtcgtc gttgtccctg ttcgttcgga aaaaggaaga taggttccca cctgtactcg
     4981 ctcttccctg ctcttcacta aagcctgaag gcgaagatat atccgccgaa gctcttcggg
     5041 ggaggcaatc gtggcaggag gctcataata caggaagcgc cacttcgcta cggtatcgcg
     5101 tccaaaaatc tgaatcgagt gacggataaa cttgtccagc agctcgaaat acttgttctc
     5161 gtccgaggaa atctcctggt attcgatgcg gatcaggagg tggagatgat gatcttgcag
     5221 gaactggagg gccagatcgg aattcatgaa cggcgtagag gtagccacca gctcgtccgt
     5281 ttccacttcg ggaagcagcg tcttgccaaa gatcaggttg cgaattccga tataacggat
     5341 gcggagctcc tgctgtgcca tgagaacctg ctctttgaca ttctcattaa ggagctcctt
     5401 cagctggccg atgaagagaa catgcgtgga aaccgccact tcctcctgcc gggttgggtc
     5461 aagctcaatc agccggttct cgaatacagc ctcgctaata tccgagatct gctcccctgt
     5521 ctcaatgtac tgggcaagct tcgccagaat atccggggat tgcagcaccg ttctcggctc
     5581 ggaagcatgg ttagccgctg gctgtacatc atcctggagc tccgaatgct ccttccggta
     5641 ttgagcgggg gacatcccgt atgccgcttt aaatacggca ttgaagtgtt ttgagctggc
     5701 aaatccgtgc ttcaacgcaa tatgagataa cggatctgtg gaatgcagca gctcatccag
     5761 actatgcttc agccgaacca gattgacgta ctgcacgaat ccaaagccgg tcattttctt
     5821 gaaatatcga gagaggtaag aaaccgataa atactccttc tgtgcgatct catttaaggt
     5881 aatcggctcg tcgtagcgct gctcaatctc ctgaatgatg cgcataatcc gctcatcatc
     5941 gtgagaactc ccttcagaca cgggagcctc ggtcttgaag aaacgagtca gcagcagcat
     6001 catttggaat aagctgctct gcagctccag gttcggaagc gcgcctgttc gcgagtaggc
     6061 aatcataatc tcggcaacat aacgccgcag aagggcggcc atttgctcgc gcccggggtc
     6121 catctctcgc gagaagcagt cgaagtgata ggagaagtac gatttatcat gctgggcaaa
     6181 aaactgtgcc gtcaggctca gcacaatgac gatattgtcc tcctggcttg cgatctcatg
     6241 cctgtcattg cggttcagga tcaagatatc atgagcctgc agcttataat cgcgagccgt
     6301 acaattcacg gtcaggctcc cgctgatcac gaacagaatc ttcgttccaa aataactcgt
     6361 tggcggcatc gaccgaatat tttccatgct gatctcatag ttgttgttag ttgctgcatt
     6421 cggcatggtg aacgcctcct tggcttggtt taggcttgat ggacgatgac agcatttagt
     6481 gccagcattt cttgaaaaac cttaggctta gttcagttta cgcgagcctt tttttattgt
     6541 ccagacaagt gcagacgctc cagtcatcca tttccagaca aaaaggcttc aagcattaag
     6601 gcttgaaacc ttcatgaatc gcatctaacg ctcgcctgac ctttctggcg aaaacaagcg
     6661 gtttttccac ggcttcaata ttgacataaa tcaagcgggg gcgctcgaat agccattcgt
     6721 tacggacaga tgtcactttg attccttgtt tacgaatcgc cgtaatgaat ggattgactt
     6781 ctttctctaa gaaggccgct ctgcctacac aaagcgctct gcccgttctt tcatctaagg
     6841 attcgaacga aaaagaagac gttacgctaa atcttttccc caaaatcgtt gctcttattc
     6901 gctttcgatt tatggtcgag acgcattttc cgccggcaaa accgggctgg cccccgataa
     6961 tccttgagaa atgcgcacaa agtgaaccgc tattgggcat acttctcttc ctcccctgtc
     7021 ttcatttagg gtatgagtac aggaacagga gtgacccgga ttatcgccta ctccaacgat
     7081 gaactaattt tttataaaaa cgatcccctt cttatcccga accgcttcgc tgcaagcaaa
     7141 cgctaatgat atccttttct tgacaaaagc caagacagat atcaaaccag cattcactca
     7201 tcattctgcc taatccggtg tattgccaac tatcaaagtg cgtaagcagc cgttcccacg
     7261 atagtgcgga ttcaaaagaa gccattctat gaaagcaatt gatgaagtgt atgcgctgta
     7321 ctttgccatg ttgacactag aggcttatca atcaacacca tttcatttga gcgtgaatca
     7381 aatcaagcag attcaccaaa tgaaaaaagt cctgcaattt gaagcacatc agcagcatca
     7441 tgtaagtcgt tttttagata agattctcaa aagcattctg aacgagagta cctgtaagat
     7501 tcaatatgta aaaaatgatc agaaaaaaag ctgccatgtt caatttttca aaatttccgc
     7561 caagtttggt caatggtatg ctgccggaat cgagttaaat acgaataaat atcgagtttt
     7621 cagatgtgac agaataaccg gaatcaaaga agaggtgcaa gaaaccacca aaaaagcgcc
     7681 ttgcagacgg acctgcgaag gcgctttgtt cggggagcgg ttaccccgga tcaatcgaac
     7741 aatactattt ctctaaccat aaggccggta cgttaagcgg ttcccagccc gccatcgaaa
     7801 tatgttcttg caggcactgg tacgttgctc cgccgtaagt cacttcgtcc ccgatcttat
     7861 acgacatacc cggatcccac ggcgtagtcg gagacggctg tgacgaaccg gaatccgtcg
     7921 ttaccgttac ggcattgctt gctgcggact gattacctgc ggcgtctatc gctctaactg
     7981 tgaaagtata tgttgtattg gccgtcaagt cggtaaccgt cgccgaagtc gtcgtcactg
     8041 tggccgctaa cgagcttccg ttatatactt catatgcagt tacgcccgcg ttgccagtag
     8101 aagcgctcca ggtaagcgat acgcttgtgt cggttatgtc cgtggatatt aaattgtcag
     8161 gtgcgctcgg ggcttgcgta tcgtcaccgc cgcctgccgc tagcacagca gcgtgcgcgt
     8221 caacaatgcc atgcccatac tgatcggagc ttccggcagg ctgcgctgta ttccggagaa
     8281 tatctccggc cgcggcaggg ctcagattcg gattgaccga tctcatcagc ccgaatacgc
     8341 ccgttacatg tggggttgac atcgaggtgc ctgacagggt tgtgtattgg ccgttcttat
     8401 atgtgctgta tatgttcgac ccaggagcca tcacatcaag acccggtcca taattggaga
     8461 agcttgaacg cgttctgctc gaggtcacgg aaccaaccgc gatcgagccg ctgtaagccg
     8521 ccggataaga gatgattggg cgtccgtcat tgccagcggc cgccaccacg atagtgccca
     8581 agctgactgc ggtttgaatc gcctcatcca tcccttgatc gtaaccgccg ccacccagcg
     8641 acatattgat gacatcggct ttaatattag cggcgtaaac aataccttgt tgaacgccat
     8701 acagcgaacc tgaaccgctg tcgttaagca ctttaatagg aatcagggtc gcgttctgca
     8761 tgacgcctga caccgatcca taactggcga tcgttcccgc gacatgagtg ccgtgcccat
     8821 taccatcgtt tgtggtaccg cccacaaagc tgctgcccaa gctagtgttc accagatttt
     8881 tcaggctcgg atggttgctg tcaattcccg tgtcaaggac gccgatccgc actgagctcg
     8941 acccggtcgt aatctcccag gcttgcggaa ccttaatcat ctcataatgc caacgttggt
     9001 tgttgtgaat atcttgaggt gaaacatcct gcacggttgc ggtttcaagc gcgtacattt
     9061 tgcggttttc cgtgacgtac cgaacattga agccgaggtt ggctagtgtt ttctccaacg
     9121 atattttggc ggaatcgatt gacttgtagt cctctacagc gtactcgacc aaatagacca
     9181 atcccatttt ttctatcgcc gtagccctta catcgctatc cagcgattgc accgagaagc
     9241 tgccggcatc ctgcccgaac agtgaatcgg caatcgtaaa accgctctcc gtgagcgaat
     9301 ccgcttccat caatatatca tccgcgcttt ggctcgaatc catgaacggt tcctctagcg
     9361 acaccacaag ctgaccttca aaataatcag tcgagtgacc ctgagccggg ctgccaaacg
     9421 acacccctgt tactaaactt accattaaca aaatggcgac taaaacagag cttagaaact
     9481 tcttcatcat taaccctcct tcacggaata aattatttgt gctgctttcc tgtgttcagc
     9541 atgatgaaat agagttcgtc acgatgctga gaaagcgcat tcaatattca gatctaccaa
     9601 cctccttttt tcggttcttt ctccctgact tctcctggat cccccccttc ttaacgccat
     9661 taattaattg ggattttcgg taaataaatt actctttttc ccaactgact ttattttatc
     9721 atcatttttt tggaaaagta aacaaaaaaa taaaaagaaa atccatctgt gaacatggac
     9781 ttgtccctga aaacccattc ggtaatttcc cagcttgtta tgaaaatcga acagcaactt
     9841 tatttctctc tatcaacgca cagcactccg catatgtgaa atgctgacgg tatgtttatg
     9901 tgtgaccttt ttgattgatg tgcagccaac gttgctgcta cgatagttca acgcagcaag
     9961 ctaattataa ctaatgaaat ggtagaggag ttattcacac atgaaaagaa ttgtaacact
    10021 gagcacacgc aaactgatgg acactgcaaa acacggcgga tgcggcgctt gccagacatc
    10081 ttgccagtcg gcttgcaaga cttcctgtgg cgttgccaac cagcgttgtg agaacgcaat
    10141 gaacaaatag aattgaaact caccgccgtc cttacaagga cggcgaagtt gtttatatac
    10201 tggctagccg cctgcaattt gtagtcaaaa aggagcttga ttcgcagtat gattcatcaa
    10261 tatcaactga acggatacaa catcgtgatc gatacctata gtggctcagt gcatgttgtt
    10321 gatgatctgg cgtatgagat cattgcgctc tatgagcatg cagcacccga acaaatcctg
    10381 acgataatga aggaaaaaca gtattcagag gaaagcattc gagagacgat ctcagaggtc
    10441 gaggaactca taagcaatgg acagctcttt acagaggatg cgtatgaaga gctgtctatt
    10501 gatttacaaa aacgaaaaac gtatgtgaaa gcgctctgtc tcaatgtcgc gcatacctgc
    10561 aatctgtcat gcgaatattg cttcgccagc caaggaaagt acaatgggga tcgagcaatc
    10621 atgagcttag aggttggaca aagagctatc gattatttac tggagcattc gggccatcac
    10681 cgcaaccttg acattgactt tttcggcgga gaaccgctta tggcttggaa agtcgtcaaa
    10741 cagattgtag cgtatgcaag aagcaaggaa aaggaatgga agaaaaaatt ccgcttcacc
    10801 ttcacaacga acggcatgct gcttaacgat gaggtcactg aatttttaaa tcaggaaatg
    10861 tacaatgtgg tcttaagcct ggatggaaga aaagaggttc atgatcggct gcgcacaacc
    10921 gttaccggca aaggcagtta tgattctatc gtgccgaagt tccaggaatt catccaaaag
    10981 cgcggagacc aggaatacta tgtacgggga acttatacac ggaacaatgt cgacttcacc
    11041 aatgatatct tccatatcgc agatcttggt tttgacaaaa tctcgatgga acctgtcatc
    11101 tgtgatcctc gggaacccta tgcgcttacc gagaaggatc tcccggagat ttacaagcag
    11161 tacgaaattc tcgccaaaga aatgattgag cgcagtgaac aaggcagagg gttcacattc
    11221 tatcattaca tgcttgatct ctctgagggg ccatgcatcc agaagcgaat cacgggctgc
    11281 ggatcaggca cggaatacct cgctgtcacg ccatggggcg agttgttccc ttgccaccag
    11341 ttcgtagggg atgaagcgta cagcatgggg aacatctggg atggcatcac gcggccggag
    11401 ctgcaatgcc aatttagaga gagcaactgc tacacgaagc cggagtgcaa ggattgctgg
    11461 gctaagctct actgcagcgg gggctgtcct gccaatgccc tgcatgcgac gggctccatc
    11521 aacgggatct acgaatttag ttgtgatgtt ttccgtaagc gaattgaatg ttccatgatg
    11581 gcgaaggttg ccgagtcgat tcgagcgatg gaagaggacg gaatgtagat agatgaaaga
    11641 ggggcaccgg cccctctttg ctatttcata gtaaggggaa gaaatactat gcagagattc
    11701 ttggaaggca ttaataataa gtttactaaa tcttttatca aacttgagaa aagtctaaag
    11761 tcttttataa ttaaagtttc tcttcccata tccaaattgg ctcctgaaga acgatggatg
    11821 taagattacg gtttattttt tttgaattca tcgtcatctc gttgctaaga acgatcacgg
    11881 ttaattcctc gtcatgtagc cgtgtaacat aatgacggaa accacttgga tatcctcctg
    11941 aatgcccaac tgcttttttc cccatgacat cttgagtata ccatccatat ccatattgat
    12001 acggaaactt tttagcatgg gtcatactca tcagttctga tgtttctttg cttatcaata
    12061 cattattacg cagggctctg tcaaaccgtt ctaaatcttc aactgtagaa atgatatccc
    12121 cagctgcata cgctgcagaa ttatgcatta agggtccggc tttcccccct acatgtcctt
    12181 ccgcttttgg tataccagcc ggaaccgtaa acatagaatt aaacatgtta cttggctcaa
    12241 aaatatgctc ttctatataa tttgcatatg actgtccgct gactttttca acaataagtc
    12301 ctaacatcac ataaccagta ttactataac taaagctttt acctggggta aactctaatt
    12361 cagaatcgct aacggttttt acaatatcat ttggattcca ttctttgctg tagtcaaatt
    12421 cgaaattcgc ctttagataa tccggaagtc ccgagctatg acttagtaga tgacctattg
    12481 taatagactc tccattcgga aagtctggaa agtattgcga cattggatta tccaagttta
    12541 gaagttcctt ttctgctagt tgcatgactg ctactgcagt gaatgtttta gataatgaag
    12601 caatctgata gagcgtgctt gggctattag gtaaatcagt ggctgccaat ccataacctt
    12661 ttgtaaataa aacttcacct tcctttgcaa ttaggacggt tccctgaaat ttttcatttg
    12721 tcaaatattg atcgatttta tcagaaacgc ttccagataa attactatgg ttgttacgtc
    12781 caaataatag caaagctact atagacacga ttacaataac aagaatagta atagagaaaa
    12841 tttttgagaa tgttttcata gttattcctc tcagtctatt tctttatatt ttagtaaaca
    12901 acatctattt taaggaatga ttttccacct tattaaatca tgatcggtaa aggcatcaaa
    12961 tttactctct tctgttttag gtgtttcatt gttaataacg aacaatctgg atatctattt
    13021 ttagaaatac gatcttcaaa atgtttagga gcaaaaatgg agatcgtctc attatcatca
    13081 aaagggttaa cgatagacaa ataaaaatac atctccgttt ccttatttat catgccttcc
    13141 aattcatcaa aaggaagccg gtgcattccc tccgatccat ccattacggc tatcattttc
    13201 actcgtttga aaaagcatgc actcttttcg ttctttgaga atttttaaat ctttcattgt
    13261 aatctccctt ctctatttac atttcgagtg ttaccatcct gttcatcttt caccatactt
    13321 cgacattaat cgagttaaat cctaccaaaa agggaattgg ccctgtttaa aaacgtcaaa
    13381 agcccgccca aaggcaggcc tctttatttg agatgtgtcc ccgaacacat attattgtgt
    13441 acccctgtat ctcctattcc ttctccgcga aaacaacgaa ggtcaaaaca actatcggca
    13501 cacagttgat tagcattcaa gccacatctg aattcaaaca attaaagctc tatttcacct
    13561 gcttgatctt gctctagatg aacaagtgga ataggagagt aaataaacgt atccccgtcg
    13621 ttttcaagct tatacatgat acaaaacaaa gctgaacctc gctgatcgcc actcggtata
    13681 gagaaaatca tggctggaca gcgcagctca gcagaatgaa cgcttgcaca cagatcttta
    13741 taagttacaa cagcaaggtt gtcgacatca acgagatgct gttgacaatc cccaataact
    13801 tgcatgtaat actctatatt ctgattatac ttgttcgcga agctctgctt atactcctca
    13861 atgctaagaa agcaacactc ccaatccaaa ggtgggatac ttaacacata gcgatagaac
    13921 ttcaattttc tgattcctcc tctttgggct atcgagctat tatacgcgat catttatgca
    13981 tataagtatt ttcggataga tccatccctc ttgggtatat acagaaaaga agcaggtttc
    14041 cctgcttcct cctactaagt tccgtcaata cttcttcgat ttaattgtcc ttcctcacca
    14101 acaaagccac cgtctccaca tgtgtcgtct gcgggaacat atccactggc tgtacttcaa
    14161 gaacacggta accgccatcc gcaagcaccc gcacatccct tgccaacgta gacggattgc
    14221 aggacacgta cacaatgcgc tctgggcgca tggccagcat cgtgtcgagc agggccgtat
    14281 cgcagccctt acgcggcggg tcgacgacga tgacgtcagg cgttacgccc tgctccttcc
    14341 agcgcgggat tacgtcctca gccgggccaa cggcgaactc cgcattcgtc acgccgttca
    14401 gctcggcatt gcggcgtgca tcggcgatcg cttcctcgac gatctcgacg ccgagcactc
    14461 gcttcgcacg ctgcgccagg aacagcgaga tcgtcccgat gccgcaatac gcatcaatga
    14521 ccgtctcatt ccctgtcagg cctgcatact ccacggcctt ctcatacagc acttccgttt
    14581 gcaccgggtt cacttggtag aaggaacgcg cggatatttt gaacgcgata tccccaatat
    14641 aatccgtaat atattccgag ccccacaata cgcgggtctt gtctcccatg atgacattcg
    14701 tgcgcttcgt gttgatgttc tggcagatgc ttgtcaactg tggcaacgct tcaaccagat
    14761 cggccacaat ttccgcctca tgcggcagct tctccccatt cgtcacgagc gtaatcatct
    14821 gctcgtccgt gcggaagccg acacgcataa tcgcatgacg aaggaggccc gtgtgcgtct
    14881 cttcgttgta cggcgcgatg ccatacttgc gggcaatccg cttcacggcg cgcattgcct
    14941 catcgttacg ctcatgctgg agcaggctga catccgtatc gatgatccgg tggctcgcct
    15001 tggcgaaata ccctccaatc agttcgcccg tccgcggatc ggccccgatg ggcatctggc
    15061 tcttgttgcg gtagcgccaa ggatgctcca ttccaatgac cggcagcacc ttaatcggcg
    15121 gctgcccgtc tgcgtctcca gtctcggctc catgctccac ctggaacttg cctatccgct
    15181 ccagcacatc gacgacatgc tgccgcttcc agcgaagctg ctcgccatat tccagatgct
    15241 gcagctggca gccgccgtac gcattcgctg gatgctccag ttccacccga tgcgcgctgt
    15301 cgataagccg ctccaatact ttggcatagc cgtactgctt cttcaccttc agcacgagcg
    15361 cccgcacctg ctcccccggc agcgcgccgc tgacgaacag cgtgaagccg tccacccggc
    15421 cgacgccttc cccgtcatgg gttagcccaa taatatccag cacgacctcg tcattcttgc
    15481 ttaccggagc cgaagcggac gtctgtcccg cctggccgcg cttctttgcc gcggagccct
    15541 ccgccgttcg cgcctcggcc gaattcgcct cggcggattt cgccccgacc gatctctccc
    15601 tgaccgatct cgccctgacc gctgccgccg ttccccggcg tttccggcgc tccgccccgt
    15661 tgcctagctt tttccctgtc acaacaacat cctccgctct atcgcttgct gttcctatat
    15721 gtcaatatga cgctctagtt gccttccacc caacccgttc gacatccaag accgaatctt
    15781 gctaacttga ttaagagtat gtaagtatga taagcctgct atgagcctgc cttctatata
    15841 tacaatacac acatcctaag ccggaatctt ctatggccac atcatgtatt caggtacttt
    15901 ccgagaagaa tgcgcttctt ccctaaagtt cgtagtcccg ccccttcaag agccctgctt
    15961 caaaatacaa ccagaactct cgtgaaacga tgtaccaagt ccagtcaatt ccccttcaaa
    16021 tcggctggcc cccctatatc cggagtcatg cccacccaaa aatatacgtt cttagaattg
    16081 cttcctattt cgcgtgatta caccgcccga tgatattttg atcggtcttc cagcgtcatg
    16141 acccactttg agaattggaa tggtgacatg ctctttaggc taaccatgca ttctgcggtt
    16201 gttgtagaaa tccatataac gatcaagtgc ttcataagct acttcaaatg tcataaattc
    16261 cgtcaggctg aacagatcac gttcgagtaa gctatgaaat gactcaatgt acgcgttcat
    16321 attcgggcta cgcggcggga tccgttcatg gacgatctcc agactctcga acgtatcacc
    16381 aaccagcttg ctgacaaact gaggctcgtt gtcggtgcga atggtaggta agctgtcgcc
    16441 gggattcagg cgttcttgca gcgcacggca tagtgtctgc atgacgtgct tggcctcaca
    16501 cacgggcccc cggtattgtc cgaccacgac gcggtcaaat acgtcgatga tactgagcac
    16561 gaaaaagaat cgctgacacc caatcacgta cccatattta atgtcaattt gccatagctg
    16621 gttcacgccg gttacctgcg aggatgtttg cttgttttct ttcgttgttt ctgaagaatt
    16681 cctagctcct tgcaaatgcg gtacgccttt ttcttgttta aaatcaatcc acgttgtctg
    16741 cggaggcgca gcgccaaatt cttgtagcca taaacatgct cttctccttc cagaagttcg
    16801 agcatccatt ctttaatctg ttcatctgaa actttccggc ccgtgttcgt agaggaaaat
    16861 ccaggcacag gacgcccttt tagaccgcat gaagcctgtt cttcggtact ggatgcctct
    16921 cgtttcttcc ggccatagta cgtcgattcg cgaactttca ggatacgcag aactttagct
    16981 gctgcatgcc cccgcttaat aaacggttct gctatttcaa gtctttcaga taagcggggt
    17041 tcttcttttt tacgagttcc cgcaggatct cgatctccag ttctttttca cctaggagct
    17101 tttttgcctg ctcgaacttg gcctccacct cttgaagtcg acggagttct tgcagatgct
    17161 cgtctgctgc gggtatctcc tcttgactaa tttcgtcacg gtggtctcta acccaaacac
    17221 gtacagtctc agggtgtaca ccgtacatcc gggcgagtgt tcccacctta atgccggcca
    17281 gtgcttcctt tacgatttgc aagcgtattt ctttgctaaa gtgctttccc atacttattg
    17341 ccccctctga taacagctta taatattgga accaaaagct ccagtctgat tagggggcct
    17401 aggagaaatt accttcattt gcccttccac agctgcaaaa aaactgcaaa agtgcagtat
    17461 ttccaccaag ctctcttttt ggaaaaagga agcctgcaaa tatacatcaa tttcgcctca
    17521 taaccgccta tattcggact tttcgttcaa aatactgcat cctaacagca attctacaaa
    17581 atagatacgc acaagcaaaa aattactgta tatttgcagg attcccacaa ttaactgaac
    17641 tactttcctt cgaacaagtg cagcagccaa ccgtaatcgc accaggtatc aaaaaaccgc
    17701 aaccttcccc ggcacatcca tcttatccaa aaaagacttg gccccgcctc accggcagca
    17761 ggccaagccc tccagtttcc gcaacgcata cgcacgcccc ggccaaggcc acaactgagg
    17821 tgcaacgcca tccgcccgag ccatggcaca acagagggcg cagcgccatc ggcccgagcc
    17881 gggcacaaca gagggcgcaa caccatttgc ccgagccggg gcacaacgcc atagccctac
    17941 gcccgcagcc agggcccaca acacggccgc gatgccatcc gcagcaccca aggccataac
    18001 agaggccgca gcatggccac aggcaaggcc gcgtcggcac tcgcgacatg gactgcctcc
    18061 cctcaccgcc tgcgcccacc gcagacgagc gggaagccat tcctatcctt gctctggctg
    18121 ctcccccgga acgtcggcaa aaatccgcaa atgcgacggc agcatctgga acgttcccgg
    18181 cagcagcccg ccgtattcgc cgtccagatt cagctgcacc gtatccggcg acgtcaccgt
    18241 cacccgcttc gactggacgt ggataatgag cggatcgaga atatgatcgc cccgcagcgc
    18301 catccccgcg acgcggatga actccgccag attgcatttc ttcagcatga tcacatcgaa
    18361 caggccgtca tcgatgcgcg cccccggcgc cagtttctcg aagccgccga ccgaattcgt
    18421 attcgcaatc aggaacagca tgaactcctc atggaacacg ccgtggccgt ccacctcgat
    18481 acgcagctcc gtcggccgca ggctcgtcat cttttccagg cccttcatgt aataagccag
    18541 ctgtccgatc attgtcttca gcttgctcgg cacctcatac gtcagcccag tcagcgaccc
    18601 gccgcccgcg atattgatga aatacgtatc attcgcctgc cccagatcga tgacacgcgt
    18661 cttctgccgg gtaataatcg agcaggcgtc ctcccaatgg cgggggatgc ccagcgcacg
    18721 ggcgaaatca ttcgtcgtgc cgagcggaat aatgccgagc ggcggtcgtg acggcttgcc
    18781 ggccatgccg ttgataacct cgttcagcgt gccgtccccg ccggcggcga tgatcatgtc
    18841 atagccccgg tcgatcgcat ccgccgcgct ggccgtcgca tcgcccgcgc catccgtcgc
    18901 atgcgccgtc gcctcgatcc cggcggcatc cagcatatgc agaatgtccg ccagccgctt
    18961 cttcccttcc tcccgcccgg aagtcgggtt atagattaac cttgcttttt ttatcattcc
    19021 ttaagtcacc cgtttgcatt ctattcccat tccggcgcca tgcctgctcc gcagctccct
    19081 gatgccgggc accttcacag attgattact tacttgatta tactatggaa aatccaacat
    19141 atcactgtga aatgcgccgt cgacatcatt cccgctcaag cctgagcttg cccgaacccg
    19201 ccgccagcgt ccggccaccg cattcagccg tcctctgcct tcatcccggc cagcagccgc
    19261 tctccctcgc gggagagcca ctccaccaag gccgggtgcg gcagcagcgg gcgcccgtca
    19321 tagagcgccg gcacatcgcc cagccgctcg ggaataaccc gcgccgtgaa atagccggtg
    19381 ctaaggaaca ccggcaccac cgccacgcgc cgctcccggc ggccgagtcc cgcccgggcc
    19441 gcggcctcgg caagcgccgc gcgtgccgcc agcgtgcggt cgcccgccag caggccgggc
    19501 cccgcatcgg cgggcagcac cgccagcgcc tgctgcagct tgcgcgccgc cgcggcgatg
    19561 tcctcgcagc agagcagcgc gtgggacgcc gccgcgcagg cgctgcgctg cacgagttgc
    19621 cgtgccaggc ggcgcaggct cgcgtgccag cggcccgcga acggctcggg gcggctgcca
    19681 tgcgccacga gcagcgccgc gtcgcccgcg ccggcgccga ggccgcgcaa gcggtcctcc
    19741 accatgtgga ggaggaccgt gccctcgggc tcgcctgccg ggccatcacc gcccggcccg
    19801 tccccgccgc aagccgcggc gaacaaggcc gccccgtcca gcgggcggcc gtagcgcacc
    19861 tgcgcccgca ggcggaacgg cggcagcttc gtgtcggcga gcggcgccga agtgacgccg
    19921 agcgcataag ctatctcatc gacatgcgtg cttccgcccg atatgaacaa agggatgacg
    19981 ccaatggcat ccaccccttg tgcctccagc tcatcgatgc cgtcctgaat cgtacgtccc
    20041 ggcacgcagt ccaaaaaaga agaagcgatc ggcacccctt ccggccacgc cgcctgcgcc
    20101 atcgcttcat ctaccagtgt aacccaggaa ccgtcgggag aaccgtggct aatcaccaac
    20161 aggcccgggc gcatcgctta gcgccccaga cgttccagcg tcattttata accgtcattg
    20221 ccgtaattca agcaacgctt cacgcgggag atcgtcgccg tactcgcgcc cgtctccgct
    20281 tcaatctgat tataagtgca gcccttgccc aacatgcggg ctacctccag ccgctgggat
    20341 aaggattgga tttcattcac cgtgcacaga tcatcaaaga aaatatagca ctcttcgagc
    20401 gactccagcg tcaaaatcgc ttcaaacagc tggtcgatcg atttatcatt caatttcttc
    20461 aattgcaacc ttatccactc ctacttcttc gcatgtaatt tcattgtact gcctttacag
    20521 cgccttttca agcgttaccg tgttcgtgct ttaatgaata aaggcattca taatagcgct
    20581 ttcacgaagg attgggcgtc cacccacggg cgatcgtcca cacgtgttgt tcgcctacca
    20641 catactgtat agtaacctat ccacaaatac aatccaaaat atgacgattg tgcaaaagtc
    20701 atacggcaat ttcccgccgt ctttttgaac acgcacacgc attatgattt taatgaaaaa
    20761 ggtcgtgatg agatgaaagt acctcaccgc aatgggcggc ctggcattcc ggatccggtg
    20821 gagctgatgt cggtgcctcg catgcgcgga ccccatgcga tgcattccgc atctccgctg
    20881 gccagggagc gggcggcccg gaatcaggcc cgggcccgcc ccgccggcat ccgcatgaac
    20941 acccggagct tcaacggccc gcctcccgga ttgcctgctg gatatcctga gttgtccggg
    21001 tatacgcctt accaggaagc gcctatcgtc ccgttcaatg ccgtcgccga gacgccgatt
    21061 gaggtggccg ctcagccgga gaagaagctg ctgggcaact tctccatggg cgatctcaaa
    21121 tcgatgatcg acaagctcgg aggcatcgag ggcatcgtcg atacgatggg caaagtacag
    21181 aagattatga gcagcgtcca acaaatcatg ccggtggcca aaatgttcat gggaaccctt
    21241 ttgcccggca aaggaggtgg gaaaaagctg agcactgcgg atggcggtga cgacgcaccg
    21301 cgcagacgac ggagatattc gagcggcagc ccgcgctcgg gaagcggcaa ccgccggaaa
    21361 tcgacggcca gccgtacagg cagcgcccca cggcgtaaaa agtagccccc gcaccgcgaa
    21421 cggcactcgt ccacacagac aggaagcata gctcccaggc atatcaaaaa gccgactcca
    21481 ccgagtcggc ttttcccctt tttaataaaa cagaaaatca atgactttga ggatcaacat
    21541 cgataatccc gcacagatcg gaatcgtaat gaaccaggtc accacgatgc gtccagccat
    21601 gccccacttc accgccgaga accgcttt
//
