LOCUS       NZ_CP094446            22607 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Paenibacillus thiaminolyticus strain Mbale2 chromosome, complete
            genome.
ACCESSION   NZ_CP094446
VERSION     NZ_CP094446.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6487160)
  AUTHORS   Hehnly,C., Shi,A., Ssentongo,P., Zhang,L., Isaacs,A., Morton,S.U.,
            Streck,N., Erdmann-Gilmore,P., Tolstoy,I., Townsend,R.R.,
            Limbrick,D.D., Paulson,J.N., Ericson,J.E., Galperin,M.Y.,
            Schiff,S.J. and Broach,J.R.
  TITLE     Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of
            Paenibacillus thiaminolyticus
  JOURNAL   mBio 13 (6), e0268822 (2022)
   PUBMED   36374038
REFERENCE   2  (bases 1 to 6487160)
  AUTHORS   Zhang,L. and Hehnly,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2022) Institute for Personalized Medicine,
            Pennsylvania State University College of Medicine, 500 University
            Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-APR-2021
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_P.thiaminolyticus_Mbale2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028554415.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 07:15:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,780
            Genes (coding)                    :: 5,579
            CDSs (with protein)               :: 5,579
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 201
            CDSs (without protein)            :: 201
            Pseudo Genes (ambiguous residues) :: 0 of 201
            Pseudo Genes (frameshifted)       :: 146 of 201
            Pseudo Genes (incomplete)         :: 68 of 201
            Pseudo Genes (internal stop)      :: 17 of 201
            Pseudo Genes (multiple problems)  :: 26 of 201
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:53:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1829844
            Orig. end                         :: 1852451
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094446.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bacteria and source DNA
            available from Schiff/Broach Lab, 500 University Drive Hershey, PA
            17033.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22607
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="6"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22607
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22607
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12607](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12607)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(481..1062)
                     /locus_tag="L3476_RS08425"
                     /old_locus_tag="L3476_08420"
     CDS             complement(481..1062)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS08425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_08420"
                     /product="hypothetical protein"
                     /protein_id="WP_272827939.1"
                     /transl_table=11
                     /translation="MSKSISINRIDMKIGSTNIRILILKQSDISIIVREELGHLLIIDA
                     VDCYEMYLLASLFKHTMESHDVIFMERGSDVHADLFIFNGAVTPLTWKDLRKIKTSIKF
                     SKTEASSLALLNSHDESFWDTWEHWKYEKQLRVQANKDISIINSSQLGFELLVYSCSYL
                     ASSNTGHSHFDRNSTKSSIELIIRNVARNN"
     misc_feature    1140..1153
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.9"
                     /tool="antismash"
     gene            complement(1446..2006)
                     /locus_tag="L3476_RS08430"
                     /old_locus_tag="L3476_08425"
     CDS             complement(1446..2006)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674626.1"
                     /locus_tag="L3476_RS08430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08425"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_272827940.1"
                     /transl_table=11
                     /translation="MSKKVLILTGDAVEALEAYYPYYRCLEEGFEATVASPTDTKVLHT
                     VVHDFEDWQTFTEKQGYQLEAHASFEQIDPEQYDALIIPGGRAPEHIRLHKDFPRIVRH
                     FFQKDKPVMILCHASVALTVIAEEIKGREMTAYFACRPEVEAAGAKYVETRFHVDRNLI
                     SGHAWNDLPQLMREFVKQVNALA"
     gene            2160..2570
                     /locus_tag="L3476_RS08435"
                     /old_locus_tag="L3476_08430"
     CDS             2160..2570
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674627.1"
                     /locus_tag="L3476_RS08435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08430"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_272827941.1"
                     /transl_table=11
                     /translation="MMDIRKEIKEKLKNGDFTCSKELTLSMFSGKWKVVILWHLGVEGP
                     HRFSELQRLFPKITHKMLTSQLKELMEDGIVHREVYPEVPPRVEYSMTELGMTLLPIIQ
                     MMYDWGEKRISQLKLEMGEAGSEECSTTCDKG"
     gene            complement(2597..2788)
                     /locus_tag="L3476_RS08440"
                     /old_locus_tag="L3476_08435"
     CDS             complement(2597..2788)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS08440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_08435"
                     /product="hypothetical protein"
                     /protein_id="WP_165643528.1"
                     /transl_table=11
                     /translation="MGIETTQYSRGFFERFGFTAERAIPDGFASGTILWRWSSISRSKT
                     MQNNGHDKSAGNAMFREA"
     gene            complement(2842..3198)
                     /locus_tag="L3476_RS08445"
                     /old_locus_tag="L3476_08440"
     CDS             complement(2842..3198)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS08445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_08440"
                     /product="hypothetical protein"
                     /protein_id="WP_272827942.1"
                     /transl_table=11
                     /translation="MSDYPIDIATFHETIFQLLGIAAVESGVENLEPIDAEMLPLSAYA
                     HLPHAALWRTGGGLENEVLIQFEFAIVQSVEGLQSLEFLAWFVRDCARGGKKIQLRPFA
                     LPPETPYARHWGRR"
     misc_feature    3245..3254
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(3737..4702)
                     /locus_tag="L3476_RS08450"
                     /old_locus_tag="L3476_08445"
     CDS             complement(3737..4702)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024273.4"
                     /locus_tag="L3476_RS08450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08445"
                     /product="DinB family protein"
                     /protein_id="WP_272827943.1"
                     /transl_table=11
                     /translation="MMLEIQPIPYKDKPVLQNLIQLYRYDSSEFDGHALSQHGLYPYKY
                     LDHQWTDEYRHPFLIKIDDEIAGFIFVLTGVPKEYVKLSTANETNVISDFFIMRKFRRR
                     NYGKQAAFYLFDRFPGAWEIRQTEINIHATQFWKRVIDEYTKIKERKMSMELKEIKQKL
                     KETRDELLGIVNALNGDQLSKRKDQNSWTISQVCQHLIKTEELYVMAIKKGLKSTEDSF
                     SENIPQWELLVDRSNKIEAPDIAKPDAEALEGTEIIEKLNHSREKLNEVLITVKDPSLL
                     SRRHFVHPVFKEMSLIEWVKSLYLHEQRHIKQIIEIKDGI"
     misc_feature    complement(4722..4742)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.73"
                     /tool="antismash"
     gene            complement(4773..5228)
                     /locus_tag="L3476_RS08455"
                     /old_locus_tag="L3476_08450"
     CDS             complement(4773..5228)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010194048.1"
                     /locus_tag="L3476_RS08455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08450"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_165643543.1"
                     /transl_table=11
                     /translation="MRIIRFRGKSFDLDNFLKKPLFAHLSTMSEEGPRDSPVWFHWERE
                     RIWIIGITSTDSFPKRIQKNPKCAIGIVDFDLYSGLVLHAGFRGDAEVKSFDHKIAYRL
                     LSRYLGPHEERWDPRFRNLDDSNVLICFRPETVVIRDQSYVPAKEMI"
     misc_feature    complement(5351..5370)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    5795..5812
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            complement(5850..7610)
                     /locus_tag="L3476_RS08460"
                     /old_locus_tag="L3476_08455"
     CDS             complement(5850..7610)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011248399.1"
                     /locus_tag="L3476_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08455"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_272827944.1"
                     /transl_table=11
                     /translation="MKRLTLKQFIGILDKYRPSGWLLFIALLLSIIQTGISLIIPLVSM
                     ELVDLLVVEEFNIFTLLGLLLLFMFQVSLSGISLYMMIYIGEGIIVRLREDLWRRVVRF
                     PVKFFDANNSGEIMSRITNDTMVMKNFFVEHLIPFFTGLITITGSLFILFLIDWKMALI
                     FLLVFPAAFLVLNPLGKKMYRVSKDVQTETALFQGNLSRVLSDVRLVKLSVAENEEAVQ
                     GAKRARRLYKYGLESGKVIAVVSPLITTTLLIVLVGIFGYGGYQVATGSLSAGALVAIV
                     FYIFQIMTPVTLMAQFFTQAQKAMGATERVNSLLVEELEEVVVSNKENVKEDIEAGITF
                     SNVVFSYSEKGEVLNNISFTAKEGKKTAIVGESGAGKTTLFSLLERFYIVDSGDIFYNG
                     RSIYSHELSEWREKIAYVSQDTPIMEGSIKDNLVYGIKKDISDSIIFDALKSADLDSFV
                     SSLPQGLDTEVGEKGIRLSGGQKQRIAIARAIIRDPKILLLDEATAHLDSQSEALVQEA
                     FNNLMRDRTTIIIAHRLSTIKDADCIVVIQEGKVSGCGSHYELYETNQLYKNLFNQQTF
                     SKELVLSGNV"
     gene            complement(7789..8631)
                     /locus_tag="L3476_RS08465"
                     /old_locus_tag="L3476_08460"
     CDS             complement(7789..8631)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="L3476_RS08465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08460"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_272827945.1"
                     /transl_table=11
                     /translation="MIHIEKLLEIAKNPEPFEEGTQEIWLDPDRADLVLKGHFDENIPG
                     GSRDSSFIDETIDFINNLAPVEKYKKVIDLGCGPGLYSQRLAMRGYDVVGVDFNQNSID
                     YAIREAQEKNLSIDYRNEDITNIDLENDFDLALLIYQIYGVFNPTKRKKILSNIHRGLK
                     PGGLVLLDVLSDTSYEKFEPKIVWVLSNEGSIFSDKSHLTLYAALKYPDKVTVERSILV
                     FDDGELVNYNYWNQNFTIEDLEKEADEAGFTLEKVYADVNGGEYVNNSESFAAVLKKK"
     misc_feature    complement(8774..8788)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.51"
                     /tool="antismash"
     gene            complement(8791..8916)
                     /locus_tag="L3476_RS08470"
                     /old_locus_tag="L3476_08465"
     CDS             complement(8791..8916)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="L3476_RS08470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08465"
                     /product="class III lanthipeptide"
                     /protein_id="WP_187144229.1"
                     /transl_table=11
                     /translation="MNAVLELQKLAQATDGKGQAAEATITIITVGKSTLSVYKCN"
     CDS_motif       complement(8851..8916)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNAVLELQKLAQATDGKGQAAE"
                     /locus_tag="L3476_RS08470_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8791..8850)
                     /prepeptide="core"
                     /locus_tag="L3476_RS08470_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.00"
                     /molecular_weight="1904.3"
                     /monoisotopic_mass="1903.1"
                     /core_sequence="ATITIITVGKSTLSVYKCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAVLELQKLAQATDGKGQAAE"
                     /leader_location="[8850:8916](-)"
                     /alternative_weights="1922.3"
                     /alternative_weights="1940.3"
                     /alternative_weights="1958.3"
                     /alternative_weights="1976.3"
                     /alternative_weights="1994.4"
     misc_feature    complement(8909..8920)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            complement(8950..9075)
                     /locus_tag="L3476_RS08475"
                     /old_locus_tag="L3476_08470"
     CDS             complement(8950..9075)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="L3476_RS08475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08470"
                     /product="class III lanthipeptide"
                     /protein_id="WP_187144229.1"
                     /transl_table=11
                     /translation="MNAVLELQKLAQATDGKGQAAEATITIITVGKSTLSVYKCN"
     CDS_motif       complement(9010..9075)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNAVLELQKLAQATDGKGQAAE"
                     /locus_tag="L3476_RS08475_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8950..9009)
                     /prepeptide="core"
                     /locus_tag="L3476_RS08475_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.00"
                     /molecular_weight="1904.3"
                     /monoisotopic_mass="1903.1"
                     /core_sequence="ATITIITVGKSTLSVYKCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAVLELQKLAQATDGKGQAAE"
                     /leader_location="[9009:9075](-)"
                     /alternative_weights="1922.3"
                     /alternative_weights="1940.3"
                     /alternative_weights="1958.3"
                     /alternative_weights="1976.3"
                     /alternative_weights="1994.4"
     misc_feature    complement(9068..9079)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            complement(9109..9234)
                     /locus_tag="L3476_RS08480"
                     /old_locus_tag="L3476_08475"
     CDS             complement(9109..9234)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="L3476_RS08480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08475"
                     /product="class III lanthipeptide"
                     /protein_id="WP_187144229.1"
                     /transl_table=11
                     /translation="MNAVLELQKLAQATDGKGQAAEATITIITVGKSTLSVYKCN"
     CDS_motif       complement(9169..9234)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNAVLELQKLAQATDGKGQAAE"
                     /locus_tag="L3476_RS08480_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9109..9168)
                     /prepeptide="core"
                     /locus_tag="L3476_RS08480_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.00"
                     /molecular_weight="1904.3"
                     /monoisotopic_mass="1903.1"
                     /core_sequence="ATITIITVGKSTLSVYKCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAVLELQKLAQATDGKGQAAE"
                     /leader_location="[9168:9234](-)"
                     /alternative_weights="1922.3"
                     /alternative_weights="1940.3"
                     /alternative_weights="1958.3"
                     /alternative_weights="1976.3"
                     /alternative_weights="1994.4"
     misc_feature    complement(9227..9238)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     gene            complement(9268..9393)
                     /locus_tag="L3476_RS08485"
                     /old_locus_tag="L3476_08480"
     CDS             complement(9268..9393)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="L3476_RS08485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08480"
                     /product="class III lanthipeptide"
                     /protein_id="WP_206108493.1"
                     /transl_table=11
                     /translation="MNAVLELQKLAHDTDGKGQAAERTITIITIGKSTLSVYKCN"
     CDS_motif       complement(9328..9393)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNAVLELQKLAHDTDGKGQAAE"
                     /locus_tag="L3476_RS08485_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9268..9327)
                     /prepeptide="core"
                     /locus_tag="L3476_RS08485_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="4.30"
                     /molecular_weight="2003.4"
                     /monoisotopic_mass="2002.2"
                     /core_sequence="RTITIITIGKSTLSVYKCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAVLELQKLAHDTDGKGQAAE"
                     /leader_location="[9327:9393](-)"
                     /alternative_weights="2021.4"
                     /alternative_weights="2039.4"
                     /alternative_weights="2057.4"
                     /alternative_weights="2075.5"
                     /alternative_weights="2093.5"
     misc_feature    complement(9386..9397)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     CDS             complement(9424..9567)
                     /gene="allorf_1839268_1839411"
                     /locus_tag="allorf_1839268_1839411"
                     /protein_id="allorf_1839268_1839411"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKKMNAVLELQKLAHDTDGKGQADVIPTITTITTTRWSLTSNFLC
                     RQ"
     CDS_motif       complement(9496..9567)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKMNAVLELQKLAHDTDGKGQAD"
                     /locus_tag="allorf_1839268_1839411_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9424..9495)
                     /prepeptide="core"
                     /locus_tag="allorf_1839268_1839411_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.50"
                     /molecular_weight="2490.9"
                     /monoisotopic_mass="2489.4"
                     /core_sequence="VIPTITTITTTRWSLTSNFLCRQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKMNAVLELQKLAHDTDGKGQAD"
                     /leader_location="[9495:9567](-)"
                     /alternative_weights="2508.9"
                     /alternative_weights="2526.9"
                     /alternative_weights="2544.9"
                     /alternative_weights="2563.0"
                     /alternative_weights="2581.0"
                     /alternative_weights="2599.0"
                     /alternative_weights="2617.0"
                     /alternative_weights="2635.0"
     misc_feature    complement(9551..9562)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(9689..9835)
                     /locus_tag="L3476_RS08490"
                     /old_locus_tag="L3476_08485"
     CDS             complement(9689..9835)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="L3476_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08485"
                     /product="class III lanthipeptide"
                     /protein_id="WP_272827946.1"
                     /transl_table=11
                     /translation="MNAVLELQKLAHNTDGKGQAIDATPTTTVFPPPIYSTVSVSAWEC
                     LKN"
     CDS_motif       complement(9770..9835)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNAVLELQKLAHNTDGKGQAID"
                     /locus_tag="L3476_RS08490_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9689..9769)
                     /prepeptide="core"
                     /locus_tag="L3476_RS08490_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-1.90"
                     /molecular_weight="2666.0"
                     /monoisotopic_mass="2664.4"
                     /core_sequence="ATPTTTVFPPPIYSTVSVSAWECLKN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAVLELQKLAHNTDGKGQAID"
                     /leader_location="[9769:9835](-)"
                     /alternative_weights="2684.0"
                     /alternative_weights="2702.1"
                     /alternative_weights="2720.1"
                     /alternative_weights="2738.1"
                     /alternative_weights="2756.1"
                     /alternative_weights="2774.1"
                     /alternative_weights="2792.2"
     misc_feature    complement(9828..9839)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(10001..12607)
                     /gene="lanKC"
                     /locus_tag="L3476_RS08495"
                     /old_locus_tag="L3476_08490"
     CDS             complement(10001..12607)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="L3476_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08490"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_272827947.1"
                     /sec_met_domain="micKC (E-value: 2e-135, bitscore: 451.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 5.9e-20, bitscore: 70.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.4e-13, bitscore:
                     47.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGNMLYHQYMKPDSEYYEKMSAIEEAYEVNEIPDTYDVISDSDS
                     VWKHYHFKGLTLPEQGWKIHVTATFEDSQSVLEKVARLCIDRKIEFKHLKDRNSFIEMN
                     SKNANRASSGKFITIYPINNESFVELLELISSTIHDFQKGPYILNDKRWKNSNVFYRYG
                     GFKTIINEHGEHCIRDEQGNLIKDQRTPFYQVPDFVKDFDDYLNTINNDLETKAEGNLE
                     KYEIETALTYSNAGGVYRATRKKDNMKVIIKEARPNAGLDGAGQDALSRQKIEYDALKK
                     LKDVPGVVNLIEYFQEWEHYFLVEEFIEGQDLRQWIARTFPFVKDSELIRDHAKNVKKI
                     LLQLFPLIDHMHQNGVAMGDLQPSNVMVTEDLTVRIIDFETAMPVNSEDNPSMATTGFV
                     SREMKVSGARDWFGLKKIVMFLVLPVLSSEDLEGYLQSNHHNWIKENYGDSFYRFIVDL
                     QEKCNKRINDYQQYTPKEINLSDQSSDFNISSIIYKLIKGIENNLTNDERFINGDIRQF
                     MMSGGKFNFLTGGSGTAFTLTKKQSKTVEVDKWIQSFLLDNLGRIEDNGLLTGKTGILA
                     LLYAKGYKEVVFNEVRVLKDNINETNISLRSGLSGIGLFVISLYLETENKEYLQFAIEI
                     EELIECNRVKGEPLRVNDWMAVDIGAIDGLSGVSLFYSALYSATNNKKYLEKAELLLKE
                     DLESTKKDDVSGVLQTLDKRNRLLPYLSGGSIGIAISIWFLNHVSGQDLYREEMDAVSK
                     LSKICCTISGSLFDGAGSFLLIPSMMEHGKNREEIVSDVLKLLNLFLIEKNGYYVYPGQ
                     FSFRLADDVYTGSSGIILALMGVVKDNPLYWLPLINSDEFLEKTKAKALVVTSEQG"
     gene            complement(13227..14510)
                     /locus_tag="L3476_RS08500"
                     /old_locus_tag="L3476_08495"
     CDS             complement(13227..14510)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002150927.1"
                     /locus_tag="L3476_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08495"
                     /product="pitrilysin family protein"
                     /protein_id="WP_272827948.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 1.3e-17, bitscore:
                     62.6, seeds: 24, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M16_C (E-value: 8.7e-18,
                     bitscore: 63.4, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESMVYKRVQETIYYEKLTNGLEVFILPKKGFHKTFATFTTKYGS
                     VDNKFSTPGNNCVTQVPDGIAHFLEHKMFESEKFDVFHTFAKQGAFVNAFTSFTRTAYT
                     FSATSNINNNLITLLDFVQEPYFTDENVEKEKGIIEQEIKMYQDSPDWRARFGILENMY
                     KSHPVKIDIAGTITSINQITKEDLFTCYNTFYHPNNMLLFVIGPVVPEEVIRLIRSNQN
                     QKTFREPTEIHRIYPEEEAKVNRRSSILKMPVETPKVLIGFKESNPKRQGQDMLKYELS
                     LNVLLELMFGNSSEAYEKMYNNGYLDETFTFDYTNEQGFGFSVIGGNSQEPEKLINIVD
                     ETIVGFKKKSIKKEDVQRVIKKEMGNFLRAINSPQFIANQFTRYRFNKMDLFEILPTLE
                     NLIEKELEEVLHQHFSDISRTTLIVNGD"
     gene            complement(14516..15790)
                     /locus_tag="L3476_RS08505"
                     /old_locus_tag="L3476_08500"
     CDS             complement(14516..15790)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002150929.1"
                     /locus_tag="L3476_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08500"
                     /product="pitrilysin family protein"
                     /protein_id="WP_087443887.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 5e-24, bitscore:
                     83.7, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEIAIRSSEQNGLHLHLCNTDKFKTISIMLTMKSPLQKDLITAR
                     ALIPHILNGGSKNYPHHKLIKQKLDEMYGATLSPDVKKEGDNHIISFRMEIPAAQYLNV
                     TNALLESALDLLHDIVYSPVLENGVFNSSIVEQEKRSLKQRLASMYNEKMLYTSVRLIE
                     EMFEGEPYQLPAYGSEKDIDSLSDLSIYQIYEDLLQNDRFDLYIVGAFNEDEVKLMVHD
                     VFSEQHNNKPVNTISPARKDRNGIKIIQDKQDVNQGKLLLGYRTYSTIQDEDFEATRLA
                     NAIFGRYPSSKLFINVREKKSLAYFVFSQLESNKGLLLTMAGIDFDNYERAVEIIREQE
                     YAMKEGNFTEDEVEQGKAMLINLLLEAYDTPLGIIDISMEAVDSGFSSNIVDQINRINR
                     VSKSDVIRAANKWELDTIYFLNRKE"
     gene            complement(16432..16557)
                     /locus_tag="L3476_RS08510"
                     /old_locus_tag="L3476_08505"
     CDS             complement(16432..16557)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="L3476_RS08510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08505"
                     /product="class III lanthipeptide"
                     /protein_id="WP_187144231.1"
                     /transl_table=11
                     /translation="MNAVLELQKLAHDTDGKGQAADAGITTIITICSVLSVYKCC"
     CDS_motif       complement(16492..16557)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNAVLELQKLAHDTDGKGQAAD"
                     /locus_tag="L3476_RS08510_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16432..16491)
                     /prepeptide="core"
                     /locus_tag="L3476_RS08510_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="4.30"
                     /molecular_weight="1898.3"
                     /monoisotopic_mass="1897.0"
                     /core_sequence="AGITTIITICSVLSVYKCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNAVLELQKLAHDTDGKGQAAD"
                     /leader_location="[16491:16557](-)"
                     /alternative_weights="1916.4"
                     /alternative_weights="1934.4"
     misc_feature    16705..16719
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.52"
                     /tool="antismash"
     gene            17668..17934
                     /locus_tag="L3476_RS08515"
                     /old_locus_tag="L3476_08510"
     CDS             17668..17934
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009595112.1"
                     /locus_tag="L3476_RS08515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08510"
                     /product="CD3324 family protein"
                     /protein_id="WP_143799812.1"
                     /transl_table=11
                     /translation="MKYVNADHVFPEALIREIQKYIQGGLVYVPTPKSLHKKWGENTGS
                     RQLLNRRNADIRHQFEEGLTIDDLAEQYCLSEESIKKIVYAKS"
     misc_feature    complement(18087..18102)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.32"
                     /tool="antismash"
     gene            18283..19158
                     /locus_tag="L3476_RS08520"
                     /old_locus_tag="L3476_08515"
     CDS             18283..19158
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018757229.1"
                     /locus_tag="L3476_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08515"
                     /product="phosphotransferase"
                     /protein_id="WP_272827949.1"
                     /sec_met_domain="APH (E-value: 3.3e-23, bitscore: 81.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQRYLLRIHSDRCGKKEICSELALLQALNQSEGLIVPEGVAGKD
                     GSYVMTIDTETGYLRPYVTLMRWVEGQHASEMTDNQIYRMGAMMGRLHESAAGITLPPG
                     FTRPEWGVDSFAGEMKKLERYYYRFLSEQAWSIYQDAAEKIMSHISVMEKNEDNYGLVH
                     ADLHSGNIVFNGEEPCPIDFGRCGYGYYLYDMAGALLELGPKQREHFIKGYESVRTLPL
                     NYVRDVECFFVMFMIENGCHHASNPEETNNLISEQPFALAYLREFLQQSSFLFQKIEPV
                     SMGNSASPLE"
     gene            complement(<19427..19501)
                     /locus_tag="L3476_RS08525"
                     /old_locus_tag="L3476_08520"
                     /pseudo=""
     CDS             complement(<19427..19501)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129672.1"
                     /locus_tag="L3476_RS08525"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08520"
                     /product="shikimate kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLIILFGPQAVGKMTVGQSLANLT"
     gene            complement(19859..20284)
                     /locus_tag="L3476_RS08530"
                     /old_locus_tag="L3476_08525"
     CDS             complement(19859..20284)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003334041.1"
                     /locus_tag="L3476_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08525"
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="WP_143799810.1"
                     /transl_table=11
                     /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSDLRRLMPS
                     ITQKMLTQQLRELEEDGIVNRMIYHQVPPKVEYELTEYGWSLKPILDSLCMWGENHIIK
                     EYGDKFAVLEDNILNNKDIGLATETDKSSKEMETKFD"
     misc_feature    20450..20464
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 21.84"
                     /tool="antismash"
     gene            20453..21655
                     /locus_tag="L3476_RS08535"
                     /old_locus_tag="L3476_08530"
     CDS             20453..21655
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006674645.1"
                     /locus_tag="L3476_RS08535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_08530"
                     /product="MFS transporter"
                     /protein_id="WP_143799809.1"
                     /transl_table=11
                     /translation="MSVDKKRATFALLALAISAFAIGTTEFISVGLLPLIANDLHISVT
                     LAGLTVTLYALGVTFGAPILTSLTSGVPRKILLIGIMLVFIIGNSLAAASTGIGLLLAA
                     RIISALSHGVFMSIGSTIAADLVAEDRRASAISIMFSGLTVATVTGVPLGTFIGQQLGW
                     RAAFATILIVGIIALIANLILVPGNLRKGVRTPVRDQVKIVTNGRLLLAFLITALGYGG
                     TFVVFTYLSPLLHDITGFKESTVALILLLYGIAIAIGNMIGGKAANRKPLTALLYMFLI
                     QAAILLLLTFTAPYKVAGLITIFCMGLLAFMNVPGLQVYVVMLAERYAPQAVDVASSVN
                     IAAFNAGIALGAYLGGIVTGHLGLIHTAWIGSLMVMAAVLLTWWSRTLERKDMASAALA
                     S"
     misc_feature    complement(22104..22113)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 taataaattg aaaaacacga gccaaagact gcttggttta tgtagatcca tactcgattc
       61 aagaccatct gtatacgttt ctaatccgaa aaaacataca ctgaaaatac ataaagagcc
      121 gtttagtttc ctggcccact tgataactct ccttttatcg ttatcagcta gtcgaaaaat
      181 aagtaaagta aaactgtaaa aaaggattac ggatattata atgattaata cgtctttcat
      241 ctttcttcct ctgttttcat attaatcgtc ttaaaataag ttcagtcaac ttggttactt
      301 ccctacttct aaaatgctgt gaatccactt ctatcatcat cgcaaatagt tttgttgctg
      361 tccaaatgaa ttattaatgt tcttcgattc ctaacagata cgctgtcaaa ggacgtactg
      421 cctaaagtga ttattattat agtgccactt taaagtacta acttgtaatt atcattatct
      481 ttaattattt cgagctacat ttcgaattat tagttcaatt gaagatttcg ttgagttcct
      541 atcaaagtga gaatgccctg tatttgaact tgcaagataa gaacatgagt aaactaatag
      601 ttcaaatcct agctgcgatg aattaattat acttatgtct ttattggctt gtactctcag
      661 ttgtttttcg tacttccaat gttcccatgt atcccagaac gactcatcat gcgagttcaa
      721 taatgctaag ctggaagctt ctgttttgga gaatttaatt gacgttttga tttttctaag
      781 atctttccaa gttaacgggg ttactgcccc attaaagata aataaatccg cgtgcacatc
      841 gctgccacgt tccatgaaga ttacatcgtg actttccatt gtgtgcttaa ataaactagc
      901 caataaatac atctcataac agtcaactgc atcaattatt agtagatgac ctagttcttc
      961 tcttacaatg atactaatgt cactctgctt tagaattagt attctaatat tggttgaccc
     1021 tatcttcatg tctattcgat taattgagat tgatttagac atatctaaga ctccaatgtg
     1081 taatgtatta cgccgatttc ctataacgta ctttttagga ttgacttatt acgatgggaa
     1141 ttttgaaaaa aaacaaacga taatgacttt gaaggaaaaa ggaagctcgg aatttttttg
     1201 gtttaacgat tgaatatcat ccacctattt ataaaacatc cttcgtatac tccttttctg
     1261 agaatcgcgt cagagctgtg aatgctgtga tagctctgca cattatcgct atccacgctt
     1321 cctagcacaa tatcagtttc gttactctcc cctaagtata actccagttc ataataatgg
     1381 aaacgcaaaa cacagcaaag gacagcaact tcatgctgtc cttcgctctt cttatttgat
     1441 tacatttaag ccaaagcatt gacctgcttc acgaattctc tcatcagctg cggcaagtcg
     1501 ttccatgcat ggccggaaat cagattgcga tccacgtgga accgggtctc tacgtacttc
     1561 gcccccgccg cttccacttc cggacggcaa gcgaagtagg ccgtcatctc ccgccctttg
     1621 atctcttcgg cgatcacggt cagcgccacg ctggcatggc ataggatcat gaccggtttg
     1681 tccttctgga agaaatggcg gacaatccgc gggaaatctt tatgcaggcg aatatgctcg
     1741 ggtgcccgtc ctcccgggat aatcagggca tcatactgct cgggatcgat ctgctcaaat
     1801 gaagcatggg cttccaactg gtagccctgc ttttccgtaa atgtctgcca gtcttcaaaa
     1861 tcgtggacga cggtatgcag tactttcgta tccgtcggcg aagcgacggt agcttcgaat
     1921 ccttcctcca agcaacgata atagggatag tatgcttcca atgcttcaac cgcatcgccg
     1981 gtcagaatca gcactttttt agacattgtc gtgtcactcc tttacaatat aagaagaatg
     2041 atgttcgatt aacgccatta tatcccgtat cgcgaggtgc gggaagaatg tacttttttg
     2101 tgcggtggtt acgaaaaagg tactattgga taagaacaac gaagaggtgt agtttatcga
     2161 tgatggacat acgaaaagaa atcaaggaaa agctcaaaaa cggtgatttt acctgttcca
     2221 aggaactgac cctctccatg ttcagcggca agtggaaggt ggtcatcctg tggcatctcg
     2281 gggtggaagg accgcatcgc ttcagcgagc tgcagcgcct gttccccaaa attactcaca
     2341 aaatgctgac gagccaactg aaagaactga tggaggacgg aattgtccac cgggaagtgt
     2401 acccggaggt gccgccgcgc gtggagtact caatgaccga gctgggcatg accctgctgc
     2461 cgatcattca gatgatgtac gattggggcg aaaagcggat ctcccaactg aaattggaaa
     2521 tgggagaagc cggctcggag gaatgctcca ccacgtgcga taaaggatag caccatgagg
     2581 gtggcacctt gcgccgtcac gcttctcgga acatcgcatt gccggcactt ttgtcatgac
     2641 cattgttctg cattgtcttg cttcgagaga tcgagctcca tctccacaag atcgtgcccg
     2701 acgcgaagcc gtccgggata gcccgctccg cagtgaaccc gaatcgttcg aaaaaaccgc
     2761 ggctgtattg cgtcgtctca atccccacaa ggggctctaa cgtgtcctcg tttccatcca
     2821 caaatcgatc gatatgtaat ttcagcgtct tccccaatgt ctggcataag gcgtttctgg
     2881 aggaagcgcg aaggggcgca attgaatttt cttgccgccc cgcgcgcaat cccggacgaa
     2941 ccaagcaagg aattccagtg actgcaagcc ttctaccgac tgaacgatgg cgaactcgaa
     3001 ctggataaga acttcatttt ccagcccccc tcccgtccgc cacagcgcgg catgaggcag
     3061 atgagcgtat gcggagagcg gcagcatctc cgcatcgata ggctccaggt tctcgacgcc
     3121 gctttctacc gcggctattc ctagaagttg aaaaatcgtc tcatgaaaag tggcaatatc
     3181 gatcggataa tcgctcatcg gttcttcctg atgttgatct ttagcaaaat actagagccg
     3241 cggggaaggc ggccttgcct ccgctccagg ctcccagatt gcgaacgaca gttgcaggag
     3301 gcaatgagaa aaagaggtgt gttagaagcg cagctcagca atgtcaaatc ccataagttg
     3361 tcctttaagg accaacgaat tgaattgtta gagcggcttt ttcataatta tacattgatt
     3421 cccgcacata tgatgggcat aagaagaaaa acctaggtaa ctatagaacc ctgtaatctg
     3481 tttataatca attgcctaca atgattacct atgctcacct ctggtctagc ctgcaatcgg
     3541 tgaattattt cttgtgtatt tatctctata ccatactcat cgattttcac gatccacgtg
     3601 gtgatgcctc cgcttttaaa acttgagacc tgaatcttct tcctcgcctc ccccatcttg
     3661 caaccgagtg cgaaggctac agcgtagata cggtgttatc ggatgtatcc gccttcttct
     3721 aacatgcaat ggcttactaa attccatctt taatttcaat aatttgttta atatgtcttt
     3781 gttcatgcaa gtacagtgat ttaacccatt caattaatga catctcttta aaaaccggat
     3841 gtacaaaatg tcttctgctt agcagtgatg ggtctttaac cgtgattaat acttcgttta
     3901 acttctctct tgaatgattt aatttttcaa ttatttctgt accttctaaa gcttcagcgt
     3961 ccggtttagc aatgtcagga gcttctatct tattacttct atcaaccaaa agctcccatt
     4021 gtggtatatt ctcgctaaac gaatcttccg tactctttaa tcctttcttt attgccatga
     4081 catataattc ttctgtctta attaagtgtt gacatacctg acttatagtc caactgtttt
     4141 ggtctttacg cttgcttaat tgatctccat tcaatgcatt aacaattcca agtaattcat
     4201 ctcttgtttc ttttaatttt tgcttgattt ctttcagttc catggacatc ttcctttctt
     4261 ttattttcgt atattcatca attactctct tccaaaactg agtggcatgt atatttattt
     4321 ctgtttgtct aatctcccat gcaccaggaa atctgtcaaa aaggtagaac gccgcctgct
     4381 tcccataatt ccttcttctg aacttccgca taataaagaa atcactaatg acatttgtct
     4441 cattggctgt actcaattta acatattctt tgggtacacc tgttagtaca aagatgaaac
     4501 ctgctatttc atcgtcgatc ttaatcaaaa atggatgccg gtattcatct gtccactgat
     4561 gatccaaata tttatatgga tataaaccgt gttgagaaag agcatgacca tcaaactcgc
     4621 ttgagtcgta tcgataaagt tgtattaaat tctgcagcac tggcttatcc ttatacggaa
     4681 ttggttgtat ttcgagcatc atcgccctcc actctcatac gaaaatctcc ttttctatat
     4741 ctgatatatg gatatttatg ctttgcgccg atctatatca tttcttttgc tggaacgtat
     4801 gattgatctc ggattacgac ggtttccggt ctaaaacata tcaatacatt gctgtcatct
     4861 aaattccgaa atcttggatc ccatcgttct tcatgcggac ctaaatatcg tgacagtaat
     4921 cgatatgcta tcttatgatc aaatgattta acctctgcat cacctctaaa tcctgcatgt
     4981 aaaacaagtc cactataaag atcaaaatca acaattccaa ttgcacattt cggatttttc
     5041 tgtattctct ttggaaaact atctgtagaa gtaattccaa taatccatat ccgttctctt
     5101 tcccaatgaa accaaactgg agagtctcgt ggaccctctt ccgacatggt tgacagatga
     5161 gcaaataacg gtttctttaa gaagttatct aaatcaaagc tttttccccg aaatctaatt
     5221 attctcatga tttttcacct ccctttgaat aattacctta ttgacgacgc gacccggcct
     5281 aagatagctc ctatctttgg ccgggtcgtg tgttgtctga gtcctcttcc ataattatac
     5341 atataattac caaggggcga aagcccgcag cgtgaataca gtgttagagt tctatagagt
     5401 tgaggcgtct ttattagaga aagaaggaat atgaggagcg cagacgaaga agtatagcat
     5461 cgaagtaatc atgtgaccta gaagaaggag gaactcatga attatcgagg aaggtttacc
     5521 ggatgctcta tgcaaagtct gaactatgaa cgcggttgtt tgcatagagc cttgcccata
     5581 tgcggaccaa acggcagaac tcgatggccg gcgccgcgcc aaattaggaa agcgcgtaaa
     5641 tgtggaacta atgcatagat agtaaatgag aattgaactt taaggatcaa ctgtgacaag
     5701 tcatatgggg taaatcggga tacaaagaaa tctcgagtcc caattagaga aaatagaaaa
     5761 tcccctcgag tatccagatt tttatgtaaa taggtctacc tttgagggga taaaaaatac
     5821 atcaaaaagg ccttcttcat tgaaattttt cagacattcc cactaagaac caattcttta
     5881 gaaaatgttt gctgattaaa taagttctta tataactgat ttgtttcata taattcgtaa
     5941 tgtgaaccac accctgatac tttaccttcc tgtataacta caatacagtc tgcatcctta
     6001 atagttgaaa gacggtgtgc aataattatc gttgttctat ctctcattaa attattgaaa
     6061 gcttcttgaa cgagtgcctc agattgacta tctaaatgag ctgtagcttc atctaatagc
     6121 agtatttttg gatctcttat gatggctcta gcaattgcta ttctttgttt ttgtccacct
     6181 gataagcgga tacctttttc accaacctcc gtatctagtc cttgaggcag tgatgacaca
     6241 aaagagtcta agtctgcact ctttagtgca tcaaaaataa tggaatcact tatatctttc
     6301 tttatgccat acactaaatt gtccttaata ctgccttcca taataggggt atcctggcta
     6361 acgtatgcaa tcttctctct ccattcactt aattcatgag aatatatcga tctaccatta
     6421 taaaaaatat ccccactgtc aacaatatag aatcgttcaa gtaatgagaa taaagttgtt
     6481 ttaccggctc cactttcacc cacaattgcc gtctttttac cttccttagc tgtaaagcta
     6541 atattattta atacttctcc cttttcacta taagaaaata caacatttga gaaggtaatt
     6601 ccagcttcaa tgtcttcttt gacattttct ttgttggata caacaacttc ttcaagctct
     6661 tctactaata atgaattgac acgttctgtt gctcccattg ctttttgggc ttgagtgaaa
     6721 aattgagcca ttaatgttac aggagtcata atttggaata tataaaatac tatagctact
     6781 aaagctcctg ctgacaaaga gcctgttgca acttgatagc ctccataacc aaatatgcca
     6841 actaatacaa taaggagcgt tgttgtaata agaggtgata ctactgctat tactttccca
     6901 gattctaagc catatttata taatcttctt gcgcgcttag ctccttgaac agcttcttca
     6961 ttttcagcaa ctgaaagctt tactaaacga acatcactta ataccctgct aagatttcct
     7021 tgaaataagg ctgtttcagt ttgcacatct ttggaaaccc tgtacatctt tttaccaagt
     7081 gggtttagaa ccaaaaatgc agcaggaaaa actagtaaaa aaataagcgc catcttccaa
     7141 tctattagaa aaagaatgaa aagagaacct gtaatagtaa ttagccctgt aaagaaagga
     7201 atcaaatgct ctacaaagaa attcttcatt accatagtat catttgtaat tctactcatt
     7261 atttctcctg aattatttgc atcaaaaaat ttaacaggaa atcttactac tcttctccat
     7321 aaatcttctc ttaggcggac aattattcct tcaccaatat aaatcatcat ataaagagaa
     7381 ataccagaaa gtgaaacttg gaacataaaa agaagtaaca agcctaataa agtaaaaatg
     7441 ttaaattctt caacaaccaa taaatcgaca agttccatgg aaactaatgg aattattaaa
     7501 gatatacccg tttgaattat cgataataac agtgctatga aaagtaacca cccagaaggt
     7561 ctgtacttat ctagaatacc gataaattgt tttaaagtga gtcttttcat atttttatgt
     7621 ttatcctttt atttttattt ttgaacgact tatttaaaca catattaaat atgtgaaact
     7681 ttcatatcct tagacatttt acctttagga ttcagtgtta gagccagggg attaaattat
     7741 tcctattctt gcaaacactg aatccttaaa tgggattttc ttatctgatt atttcttttt
     7801 taaaactgcg gcgaaggact cgctattgtt gacgtattct ccaccattaa catctgcata
     7861 taccttttca agagtaaatc ctgcttcatc cgcttctttt tctaaatctt caatagtgaa
     7921 attttgattc caataattat aatttactaa ctcaccatca tcaaaaacta ggatacttct
     7981 ttccacagta actttatcag gatacttaag tgccgcgtat aaagttaaat ggctcttatc
     8041 tgaaaatatg ctaccttcat tagataatac ccacacaatt tttggttcga acttttcata
     8101 actagtgtct gataacacgt ctaataatac taatcctccc ggttttaacc cacggtggat
     8161 attgctaagt attttttttc tcttagttgg attaaacaca ccataaattt gataaattaa
     8221 aagggctaaa tcaaaatcat tttctaggtc aatattagta atatcttcat tcctataatc
     8281 tattgataaa ttcttttctt gagcttccct aattgcgtag tcaatggaat tttggttaaa
     8341 atctacacct acaacatcgt aacccctcat tgctaatctt tgtgaataga gccctggacc
     8401 acaacctaag tcaataacct ttttatattt ctctactggt gcaaggttat taataaaatc
     8461 aatagtttca tcaataaaac tgctatccct gctaccacca ggtatattct cgtcaaagtg
     8521 acccttcaaa acaagatcag ctctatctgg atcaagccag atttcttgtg tgccctcctc
     8581 aaatggctcg gggtttttgg ctatttctaa taacttttcg atatgtatca ccctctcttg
     8641 attttttcat gatttttgag tataataagt gaattctggg tgcttcgctg aactccactc
     8701 aactaagcac cccagaatta ttttagtaat tgttacttgc tttgatcaaa aattgaactt
     8761 ttgcattcag ttcaattttt tgaagattca ttaattgcac ttataaacac ttaaggttga
     8821 ctttcctaca gttatgattg tgattgttgc ttccgctgct tggcctttac catcagtggc
     8881 ttgcgctaat ttttgcaatt ccaatactgc gttcattttc ttcacctcct ttaaataatt
     8941 tggctttcat taattgcact tataaacact taaagttgac tttcctacag ttatgattgt
     9001 gattgttgct tccgctgctt ggcctttacc atcagtggct tgcgctaatt tttgcaattc
     9061 caatactgcg ttcattttct tcacctcctt taaataattt ggctttcatt aattgcactt
     9121 ataaacactt aaggttgact ttcctacagt tatgattgtg attgttgctt ccgctgcttg
     9181 gcctttacca tcagtggctt gcgctaattt ttgcaattcc aatactgcgt tcattttctt
     9241 cacctccttt aaataatttg gctttcatta attgcactta taaacactta atgtcgactt
     9301 tcctatagtg atgattgtga ttgttctttc cgctgcttgg cctttaccat cagtgtcatg
     9361 cgctaatttt tgcaattcca atactgcgtt catttttttc acccccttta attaatttgg
     9421 ctttcattgg cggcacaaaa aattacttgt tagcgaccac ctagtagttg taatcgttgt
     9481 tattgtgggt attacatcag cttggccttt accatcagtg tcatgcgcta atttttgtaa
     9541 ttccaatacg gcgttcattt ttttcacctc ctttaaataa tttggctttg attacttggt
     9601 gtcgaccaac aagtatctga tattgttctt gtaattgtta ttactggtgt tacatccgct
     9661 ggttggcctt taccatctgt gtcatgcgct aattttttaa acactcccaa gcactaacac
     9721 taacagttga ataaataggc ggtggaaata cagtcgttgt tggtgttgca tctattgctt
     9781 ggcctttacc atctgtgtta tgcgctaatt tttgtaattc caatacggcg ttcatttttt
     9841 cacctccatt aaattaattt gactttcatt ctagccgcac cgaaaacttt ggtgtcgacc
     9901 aaatagttgc tagagtcgtt attattgttg tgactgttgc atcctccgct tggcctttac
     9961 catcagtgtc atgcgcttat tttgcaagct aaacatgtaa tcacccttgt tcactagtga
    10021 ctactagagc cttggccttt gttttttcta aaaattcatc cgaattaatc aatggtaacc
    10081 aatagagtgg attatctttg actaccccca ttaatgctaa aattattcct gaactccctg
    10141 tataaacatc atcggctaat ctaaaagaaa attgtcctgg gtatacataa taaccattct
    10201 tctcaattaa aaagagatta agtaacttca atacatcact aacaatttcc tcgcgatttt
    10261 taccatgttc catcatagaa gggattaaaa gaaaactacc tgcgccatca aataagcttc
    10321 cactaattgt acaacaaatc tttgataatt ttgaaaccgc atccatctct tctctataaa
    10381 ggtcttgtcc actgacatga tttaaaaacc aaattgaaat agcaattcca atagatcctc
    10441 cagaaagata aggcaatagg cgatttctct tatccaatgt ttgtaataca ccacttacat
    10501 catctttttt tgttgattct aaatcttcct ttagtaataa ctcagccttt tctagatact
    10561 tcttattatt ggtcgctgaa taaagtgctg aataaaacag cgatacccca gataatccat
    10621 caattgcacc tatatcaacc gccatccagt catttactct taacggttca cctttaactc
    10681 tgttacattc aattaattct tctatttcta ttgcaaattg taaatattcc ttgttttctg
    10741 tttccaggta taaactaatt acgaataaac ctatccctga aagaccagag cgtaaagaaa
    10801 tattagtttc attaatatta tcttttaaaa ccctcacttc attgaagaca acttctttat
    10861 aaccttttgc ataaagcaaa gccaatattc ctgtctttcc agtcaataaa ccattgtctt
    10921 caattcgacc taaattgtct aataaaaaac tttgaatcca tttatctact tctacagttt
    10981 tagattgttt tttagtaagt gtaaaagctg tgccacttcc tccagttaaa aagttaaatt
    11041 ttcccccgct catcatgaac tgacgaatgt caccgttaat gaacctttca tcattggtta
    11101 aattattttc aattcctttt attaacttat aaataataga cgagatgtta aagtcacttg
    11161 actgatcact aaggttaatt tctttaggcg tatactgttg ataatcattt attctcttat
    11221 tgcatttttc ttgtaaatct acaatgaaac gataaaatga atctccatag ttttctttta
    11281 tccaattatg atggttagat tgtagatacc cctctaaatc ttctgaggaa agaactggaa
    11341 gcaccaaaaa cattacaatt ttctttaatc cgaaccaatc tcttgcacca ctaactttca
    11401 tttctcgcga aacaaatcca gtcgtagcca tactggggtt gtcttcagag tttacaggca
    11461 tagcagtttc aaaatctatt atcctaacgg ttaagtcctc ggttaccatt acatttgatg
    11521 gttgcaaatc acccatagct actccatttt gatgcatatg atctataagc gggaaaagtt
    11581 gtaacagtat ctttttaacg tttttagcgt gatcccttat aagttcactg tctttaacga
    11641 atggaaaagt tcgggcaatc cattgcctta agtcttgccc ttctatgaat tcctctacta
    11701 aaaagtaatg ttcccattct tggaaatact caatcaaatt aacaacaccg ggtacatctt
    11761 taagtttttt taaggcatca tattcaattt tttgcctgga taaggcatct tgacctgccc
    11821 catctaaacc agcatttggt ctggcctcct tgataatcac tttcatatta tctttctttc
    11881 gagtcgcacg gtatacccca ccagcattac tataggtaag tgcagtttca atctcatatt
    11941 tctctaaatt gccttccgct ttagtttcca agtcattatt tatggtattc agataatcat
    12001 cgaaatcctt tacaaagtca ggaacctggt aaaaaggagt tctttgatcc ttaattaaat
    12061 ttccttgctc atctctaatg caatgttcgc catgttcatt aattatagtt ttaaatccac
    12121 catatctata gaatacattg ctattcttcc atctcttatc attaagaata taaggtcctt
    12181 tttgaaaatc atgaattgtt gaagatatca attccaacaa ttcaacaaag ctttcattat
    12241 taatagggta tattgttata aatttcccag aagaagcacg attagcattt ttcgaattca
    12301 tctcaataaa actgtttcta tccttaaggt gcttgaactc aatttttcta tctatacata
    12361 accgagcaac cttttctagc acactctgtg aatcttcaaa tgtcgcagtt acatgaattt
    12421 tccatccctg ttctggtagt gttaatccct tgaaatgata gtgcttccaa acggagtcac
    12481 tgtctgaaat aacatcatat gtatcaggaa tctcattcac ttcatatgcc tcttctatcg
    12541 cgctcatttt ttcgtaatat tctgaatccg gtttcatata ctgatgataa agcatatttc
    12601 cttccataca tatcccccca ttttttattc tttctctatg tatattccat atgtataggg
    12661 aaaacttgcc tattttccgc aacatttcct tacatattct tcaggtaata tgccaataaa
    12721 aggatttgaa atcgtgatat cggaaatctc tttttttact cttggaaatt ttttgtaatg
    12781 taatactacc tagtctgtaa taagggaagc aacatgggtg tgtcctatct cacttattat
    12841 aaacctacta acatggttta ttatggaagg taaatctagt gagtgagaca ggagtgaatg
    12901 tgagtattat gattgactat tggagatgtc tggctgtcac aaaaaagctt gctgattagt
    12961 tgtaagcttg taatgtgcat acaaaagggg ataaaatcac ttagccactt ttctgtacga
    13021 atgtagtagc ctagaagtat ggtgtaagaa aatatagtaa ttattaccat taataataat
    13081 attgagttta tagtaacatt tggagatgac tgtgtcaatg ctttctgatt atttttagtt
    13141 atttaatact atatttttat tttctagtaa tacagtactg atctctctag ttttgtatta
    13201 tataaaaaat ttagcagtaa ttaaatttaa tccccgttta caattaatgt tgttctggat
    13261 atgtcagaaa agtgttgatg gagtacttcc tcaagctctt tttcgattag attctcaagt
    13321 gttggcaaaa tttcgaatag gtccatctta ttaaagcgat aacgtgtaaa ttgattggcg
    13381 ataaattgag gtgaattaat ggctcttaag aagttaccca tctctttctt aattacacgt
    13441 tgtacgtcct ctttctttat tgatttcttc ttaaaaccaa caatcgtttc atctacaatg
    13501 tttatgagtt tttcgggctc ttggctgttt ccgccaatta ccgaaaaacc aaagccctgt
    13561 tcatttgtat aatcaaaagt aaatgtctca tctaaataac cattgttata catcttttcg
    13621 tacgcttcag agctattacc aaacattaat tctagtaaaa catttagaga taactcatat
    13681 ttaagcatgt cttgaccttg tcttttaggg ttagattctt taaatcctat taacacttta
    13741 ggtgtttcaa ctggcatctt caaaatactt gaccttctgt tcacttttgc ttcttcttcg
    13801 gggtatattc gatgaatttc tgttggttct cgaaatgttt tttggttctg gttgcttcgg
    13861 ataagcctta ttacttcttc aggaactaca ggcccaataa caaaaagtaa catgttatta
    13921 ggatgataaa aagtattata gcaagtgaat aaatcctctt tagtgatttg attgatagaa
    13981 gttattgtcc cagctatatc aattttcact ggatgactct tatacatatt ttctaagatt
    14041 ccaaatcgag cacgccagtc tggactatcc tgatacattt ttatttcctg ttcaatgatt
    14101 cctttctcct tttctacgtt ttcatccgta aaatatggtt cttgaacaaa gtctagaagg
    14161 gttatcagat tgttatttat gttagatgtt gctgaaaatg tatacgccgt gcgagtaaaa
    14221 ctggtaaatg cattaacaaa agctccttgt tttgcaaatg tatgaaaaac atcaaacttc
    14281 tcactttcaa acattttatg ttctaaaaaa tgcgctattc catctggaac ttgagtgaca
    14341 caattatttc ctggagttga aaatttatta tctactgaac catactttgt tgtaaatgtg
    14401 gcaaatgttt tatgaaagcc tttcttagga agtatgaaaa cttcaagacc attggtgagc
    14461 ttttcataat atattgtctc ttgtactctt ttatagacca ttgactccat attatttact
    14521 cctttctatt taaaaagtag attgtatcaa gttcccattt attggcggcg cgaatgacat
    14581 cgcttttgga taccctattt attctgttta tctgatcaac tatgttactt gaaaacccgc
    14641 tatcaaccgc ttccatggat atatctataa ttcctagagg agtatcatat gcttcaagta
    14701 ataggttaat taacattgct tttccttgtt caacttcatc ctcagtaaag ttaccttctt
    14761 tcattgcgta ctcttgttct cttataattt caactgcacg ttcataatta tcgaaatcaa
    14821 ttccggccat cgttaataac aaccctttat tgctctctag ttgggaaaat acaaaataag
    14881 caaggctttt cttttcacgc acattaatga ataatttgga agatggatat ctgccaaaaa
    14941 tcgcgtttgc caaccttgta gcttcaaaat cctcatcttg tattgtcgaa taagttctat
    15001 aacccaaaag aagctttcct tgatttacgt cctgtttatc ttgaataatc ttaataccat
    15061 ttctatcttt tctagctgga gaaatggtat ttacaggttt attgttatgc tgttcagaaa
    15121 aaacgtcatg gaccatcaat ttaacctcat cctcattaaa agcaccaacg atgtataaat
    15181 caaaccgatc gttttgaagc agatcttcat agatttgata aatggataaa tcactaaggg
    15241 aatcaatatc tttctcgcta ccatatgcag gaagctgata cggttcacct tcaaacatct
    15301 cttctatcaa acgaacacta gtatataaca ttttctcatt atacattgag gcaagtcgtt
    15361 gctttaagga gcgcttttct tgttcgacga ttgaagaatt aaatacccca ttttcaagaa
    15421 cgggactgta aacaatatcg tgtaataaat ccaaagctga ttctagtaac gcattagtca
    15481 cattaagata ttgagctgca gggatctcca ttctaaaaga tataatatga ttgtctccct
    15541 cttttttaac atctggggaa agagtagcac cgtacatctc atcaagcttt tgttttatta
    15601 gcttatggtg tgggtaattt tttgaacctc cattcagaat atggggaatt aatgctcttg
    15661 cagtaattaa atctttttga agaggtgact tcatcgtcaa cattatacta attgtcttaa
    15721 atttatctgt gttgcaaaga tgaaggtgca acccgttttg ttcactcgag cgaatagcta
    15781 tctcatccat ctcctatatc ccccttattg gaaatttttg ttatgcactt tgataaaaaa
    15841 gttgaagtaa atccctcttt ttctgatatg tgtatacttc acaactaggt ataattactt
    15901 tcattttcta cctgtattat tatattttat cataccatta tttgtactgg aagcttatta
    15961 atacgaaata attcaaatta agcatatcgt tcatatcgta tttctgtaat aataccttgt
    16021 tgatgccata agatatcgca ctattgcaaa cttagtcgcc atggaccaac aaacttcgtg
    16081 tgccaggtgt gccattgctt gaagcccgtc gggtcacctt agcttttacc cactggtccc
    16141 caaatacaaa aaagaactgg tgacagcatg gagccacgca tcgctcgcat ctgtaccaat
    16201 tcccttgtcc gattttcaat ctatcaatct ccttgaaagg cagttccccg tccatcaaat
    16261 ggcccggggt ttttggctat tttttcgata tttatcagcc tctcttgatt ttgatgattt
    16321 atgagtttaa tgagttaatt ctgggtgctt tgctgaactc cactcaacta agcacccaga
    16381 attatttagt aactgttact tggttcaatc aagaataaat tcggctttca tttagcagca
    16441 cttataaaca cttaataccg agcatattgt tatgattgtt gtgattcctg catccgctgc
    16501 ttggcctttc ccatcagtgt catgcgctaa tttttgcaat tccaatacgg cattcatttt
    16561 tttcacctcc tttaaataat ttggctttca ttaaccgcac cgaatacttg gtgtcgacct
    16621 ccccccattc atgctaaaat tatttctgaa ctccctgtat aaacaccatt ggctaatcta
    16681 aaagaaaatt gtgctggata aaaatgacca ttattttcaa tttaaaatca catccatctc
    16741 ttctctataa agatcttgtc cactcacatg atttaaaagc ctaattgaaa tagcaattcc
    16801 aatagatccc ccagaaaggt aacagttaca tcatcttttt ttgttgattc taaatcttcc
    16861 tttaatagtt gaattaatga gttacgaatt gtaccgattc catccgaacg ctgaaccgat
    16921 cattgatttt aatagaatcg agcataatat gatccatgaa ggttaagcgc cccctatttt
    16981 cctgatatat gtataatcaa caactaggta taattacttt cattttctac ctgctgatta
    17041 tattttacca taccattatt tgtaatggaa gcttattaat tggaaaatag ctgtttgatt
    17101 acgaaataat tcaaattaag gtatttcagt agtaatacct cttgatgaca taattactta
    17161 tgataaattc ttactaaata ggcctattat gaaaatcctt acttaaagaa agcgtaaaag
    17221 gccagttatg gggccctatc tggagatcgt cgacacatgg ctggaagaag ttcgcctgct
    17281 ttccccggaa acagcggcat accggcatac ggatctacca gcactgcatt ttgtatatca
    17341 aacatcggct gagatgcttt tagaagcgat gaagcggtgt ttggaagatg ggaggcgtct
    17401 taattagaga aagaaggaat atgagaggcg acgaagaagt gaagtataaa tcgaagtaat
    17461 catgtgacct agcagaagga ggaactcatg acttatcgag gaaggtttac cggatgctct
    17521 atgcaaagtc tgaactataa acaatggcgg ttgtttgcat ggagctagag aattcgctac
    17581 cgcccataca tcgcatctta tgctgctgct gctgatagct tggactttgc ttccttcatc
    17641 agtatttata taaggagcag agcgaagatg aaatatgtga acgcagatca tgttttccca
    17701 gaggcattaa tcagggaaat acagaaatat atccaaggcg gattggtgta tgtccccaca
    17761 cccaagtcgc tgcataagaa gtggggcgag aatacaggca gcagacagct gttgaaccgg
    17821 agaaacgcgg atatccgcca tcaattcgaa gaaggtctaa cgattgatga tcttgcggaa
    17881 cagtactgcc tgtcggagga aagcatcaaa aagattgtat atgcaaaatc atagaggttg
    17941 ttaggctgca tcagagcatc atctggcgca gcttttttgt aatgtttgtt tttaattatc
    18001 tattccctat ccggattgca cgcctctata tacaataata ccaacaggcg agctgcatga
    18061 tttggtatga atcctgatga cgagaggtta aaaaatcctc aaaatagggg ttggagacga
    18121 atgttagatt tttttcaatt tgacacggat gaagagagaa gattactgtt agcgcgagcg
    18181 agaaatgtag ctctcaccgc actgcagcgg tatgacatcg aatgggaacg aatacaattc
    18241 attcagctat cggatacgat tacgtatcag atcgagacga gcatgcagca gcgctatttg
    18301 cttcgaattc attcggatcg ctgcggtaaa aaagaaatat gctcagagct tgcgctgcta
    18361 caggccctga atcaatccga aggattgatc gtgccggaag gggtagcagg caaggacggc
    18421 tcttatgtca tgacaatcga tacagaaacg ggatatctcc ggccctatgt tacgttaatg
    18481 cgctgggtgg aagggcaaca cgctagtgaa atgacggaca accaaattta tcgaatgggg
    18541 gcgatgatgg gacgtcttca tgagtcagca gccggaatta cgctgcctcc cggctttact
    18601 cgtccggaat ggggagtgga cagctttgca ggcgagatga agaagctgga gcgttattat
    18661 tatcgttttt tatccgaaca agcatggagc atataccaag atgccgcaga aaaaatcatg
    18721 tcgcatatct ccgttatgga gaaaaatgag gataactatg gcctggtcca tgcggattta
    18781 cattccggga atatcgtatt taacggagag gagccttgtc cgattgattt tggacgatgt
    18841 ggatatggct attacctcta tgatatggca ggggctttat tagagcttgg cccgaagcag
    18901 cgagaacatt ttattaaagg gtatgagagc gtgagaacgc tgcctctgaa ctacgttcgc
    18961 gatgtagaat gctttttcgt catgttcatg atcgagaacg gctgtcatca tgcttccaac
    19021 ccggaagaga cgaacaatct catatccgaa caacctttcg cattagcgta tttacgagag
    19081 tttttacaac aatcatcgtt tttatttcag aaaatcgagc cagtgagcat gggcaattct
    19141 gcttctcccc ttgagtaagg aatattcctc tccctatcta attccgccct gcctggtagt
    19201 agagaggcag cgatttcagc caagaaatat agttaacaag ctccaatgag ttcctttcaa
    19261 attgcttaat gtcacttgtc cacatttttt taccaagctg gactaagacc tgcttaccgc
    19321 tgttccaatg ctcattaatt aatttcgtaa aagtatgaaa acaaccatgt acatcaccaa
    19381 cgataacgat ctattccaac attagttcta atagcttaaa attatttgta aggtttgcca
    19441 ggctttgtcc tactgtcatt tttccaactg cctgcgggcc aaataatatt atcaacttca
    19501 ttgataatcc cctaactctt cttcgaattc accaccctaa acttgcctgg gcctcctata
    19561 aaatggctta gatatagact ttactaacgg aaaatcggta cggatgtatg gaactggtgg
    19621 cgtaactaaa gaaccctatg gtttcgatgc tatattagct ttttttcggg tcttgttgat
    19681 aacgttttgt atttacgatg cgaccagcct tagatagctc ctatcttagg ctgggtcgtg
    19741 tgttgtctga tcttcttcca tgattataca tctgacaacc atagggcgat agccctgatt
    19801 gtgttattct ccatctagcg ccaccatctg tgccaccggt cggtcgtcac ccttccgttt
    19861 agtcaaattt cgtttccatt tccttcgacg atttatccgt ttcggtcgcg aggccgatgt
    19921 ccttgttgtt gagaatgtta tcttccaata cggcaaattt gtcaccgtac tctttaataa
    19981 tatgattctc tccccacata cagagagagt cgagaatcgg tttcaagctc cagccgtatt
    20041 cagttagctc atattccact ttgggcggaa cctgatgata tatcattcgg tttacgatgc
    20101 cgtcctcctc cagctccctg agctgctgcg taagcatttt ctgcgtaatg gacggcatca
    20161 gccgccgcaa atcgcttgtc cgcttcttgc cgtgggtcag gtggcacagg atcacgcact
    20221 tccatttgcc tccgatcact tccagggtag cttcaaccga gatattgtat ttctttttct
    20281 ccaaaatgac gcctcctcac aatccatggg cactttttgg tgcctatagt actaaaaagt
    20341 acgtactatt caaaacactg caatgggtac ataataacat ttaccggccg gtacttctat
    20401 catgtagctc aatcgttcga taaaaaacaa aatataggag tgggaataaa tcatgtctgt
    20461 cgataaaaaa cgcgcaacct ttgccttgtt agctttagcc atcagcgcgt ttgcgatcgg
    20521 taccactgaa tttatcagtg tgggactgct tcccctgatc gctaatgacc tgcacatttc
    20581 ggtgaccctc gccgggttaa ctgttacgtt atatgcactg ggcgtcactt ttggggcgcc
    20641 gattctaacc tctttaacgt cgggcgtacc gcgcaagatt ttgcttatcg gcatcatgct
    20701 ggtgtttatt attggcaaca gcctggcggc agcatccacc gggatcggct tgctgctcgc
    20761 ggcacgcatc atatctgctt tgtcccatgg cgtgtttatg tccatcgggt ctacgattgc
    20821 ggctgatttg gttgccgagg atcggagggc aagtgccata tctatcatgt tctccggcct
    20881 cacggtggcg actgtcaccg gtgtgccgct ggggacgttt atcggccagc agcttggctg
    20941 gagagctgcg tttgctacaa tcttgatcgt cgggattatc gcattgattg ccaatttgat
    21001 tctggttcca ggcaatcttc gcaaaggcgt ccgcacgcca gtccgtgacc aggtgaaaat
    21061 cgttactaat ggcaggttgc tgcttgcctt tctcattact gcgctcgggt atggaggaac
    21121 gtttgtggtc ttcacctacc tgtcgccgct gctacatgac atcaccggtt ttaaagaatc
    21181 taccgtagcc ctgattttgc tgctctacgg catcgccatt gccatcggca atatgatcgg
    21241 aggcaaagcg gccaaccgca agccattaac cgccttgctg tatatgttcc tgattcaggc
    21301 ggccattttg cttcttctca cattcacggc accgtataag gtggccgggc tgatcacgat
    21361 cttctgtatg gggcttctcg cttttatgaa cgtgccggga ttgcaggtat atgtcgtgat
    21421 gctggcggaa cggtatgcgc cgcaagccgt tgacgtcgct tcgtcggtca acattgcagc
    21481 tttcaacgcc ggcattgcgc ttggcgcgta tctgggcggg atcgtcactg gtcatcttgg
    21541 cctgattcat accgcatgga ttggctcgtt gatggtcatg gccgccgtac tcctgacctg
    21601 gtggagccga actttggaac gaaaggatat ggcgtctgca gctcttgcaa gctgatccag
    21661 gggtaacatg cccttttcaa ctatcgtaat ctcatctaaa taagttcaaa gcattcggtt
    21721 atggtaaccg aatagggcgg atgtattcga attcaccata ctatttattt tcaaagttca
    21781 ctgtactgga caactaacca aattaggagg caattgatta tgactcaaaa cgtacaaagc
    21841 agaacccgat tgaataacgg tatcgacatg ccttggatgg gccttggcgt ctttaaagtg
    21901 gaggaaggaa gcgagctcgt cgaggcggtg aaagctgcag ttaagcacgg ctaccggagc
    21961 atcgacaccg ctgcggtata cgccaacgaa acgagcgtcg gtcagggaat tcgcgaggcg
    22021 ctggcagaga acggactgaa cagggaagac cttttcatca cttcgaaagt gtggaacgcc
    22081 gacctcggtt acgagtcgac actcgccgcc ttcgagacaa gccttaagaa gctgggcctt
    22141 gactatctgg atctctattt gatccactgg ccggtagcca gcaagtataa agacgcctgg
    22201 agagcgctgg agaagctgta taaagacggc cgtgtcaaat ccatcggcgt cagcaacttc
    22261 caagttcatc accttgaaga tttaatgaaa gatgcggaaa tcataccggt ggtaaatcag
    22321 gtggagttcc atccgctgct gaaccagaaa gagctgcgcg acttcacgaa gaagcacggc
    22381 attcagttgg aggcgtggtc tccattgatg cagggagagc tgctcaacca tccgctgctg
    22441 aaagagatcg cggacaaata cggcaagtcc atcgcgcagg taattctccg gtgggatctg
    22501 cagcatggcg tcgtgaccat tcccaaatct acgaaagagc accggatcgt cgaaaatgca
    22561 tcgctgtttg actttgaact gtcccccgaa gatatggatc ggatcga
//
