LOCUS       NZ_CP094446            23586 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Paenibacillus thiaminolyticus strain Mbale2 chromosome, complete
            genome.
ACCESSION   NZ_CP094446
VERSION     NZ_CP094446.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6487160)
  AUTHORS   Hehnly,C., Shi,A., Ssentongo,P., Zhang,L., Isaacs,A., Morton,S.U.,
            Streck,N., Erdmann-Gilmore,P., Tolstoy,I., Townsend,R.R.,
            Limbrick,D.D., Paulson,J.N., Ericson,J.E., Galperin,M.Y.,
            Schiff,S.J. and Broach,J.R.
  TITLE     Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of
            Paenibacillus thiaminolyticus
  JOURNAL   mBio 13 (6), e0268822 (2022)
   PUBMED   36374038
REFERENCE   2  (bases 1 to 6487160)
  AUTHORS   Zhang,L. and Hehnly,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2022) Institute for Personalized Medicine,
            Pennsylvania State University College of Medicine, 500 University
            Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-APR-2021
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_P.thiaminolyticus_Mbale2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028554415.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 07:15:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,780
            Genes (coding)                    :: 5,579
            CDSs (with protein)               :: 5,579
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 201
            CDSs (without protein)            :: 201
            Pseudo Genes (ambiguous residues) :: 0 of 201
            Pseudo Genes (frameshifted)       :: 146 of 201
            Pseudo Genes (incomplete)         :: 68 of 201
            Pseudo Genes (internal stop)      :: 17 of 201
            Pseudo Genes (multiple problems)  :: 26 of 201
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:53:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1414238
            Orig. end                         :: 1437824
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094446.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bacteria and source DNA
            available from Schiff/Broach Lab, 500 University Drive Hershey, PA
            17033.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23586
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23586
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="interleaved"
                     /product="azole-containing-RiPP"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..23586
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13586](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13586)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(1383..1772)
                     /locus_tag="L3476_RS06665"
                     /old_locus_tag="L3476_06655"
     CDS             complement(1383..1772)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS06665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_06655"
                     /product="hypothetical protein"
                     /protein_id="WP_272827664.1"
                     /transl_table=11
                     /translation="MNSYISELITQLEEPISLASPSDRSITVGDEKLWIRSVTKTDTGH
                     DIVITRKQFVKWIKELISIKAGGIVVPVSSLSTARPWDPKNGNTLWEQTYSFNTTETPE
                     FLLLDGFHYIKTYNKKISIPVDNKK"
     misc_feature    complement(1776..1789)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.78"
                     /tool="antismash"
     misc_feature    1776..1790
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.78"
                     /tool="antismash"
     misc_feature    complement(1875..1889)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            2782..3555
                     /locus_tag="L3476_RS06670"
                     /old_locus_tag="L3476_06660"
     CDS             2782..3555
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015891166.1"
                     /locus_tag="L3476_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06660"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_272827665.1"
                     /transl_table=11
                     /translation="MKSEITISELAKLMNVSVHQIRYFEEKGVLQPSYTDNNQYRMYGI
                     EQVYELAHILLLRKLGVPVPSIKECMTSFTADQFRQLLHSSLRDIEMEQQRLMELQQFI
                     TKVLQEQHNVTTRSNPYQIKRRDTTYFVRWLEMDFRTKLTAKRLADHTKRIPNLFEMDI
                     HYIYDGSHINALCLEAQEPGDFCLPEGDYLSMQCSTQEEDELEQVIEQFYDYAAAQSYV
                     ISGPLVLIEKSYLSLFINHKLQYELQVLIEPVTNP"
     gene            3568..4203
                     /locus_tag="L3476_RS06675"
                     /old_locus_tag="L3476_06665"
     CDS             3568..4203
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017248549.1"
                     /locus_tag="L3476_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06665"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_272827666.1"
                     /transl_table=11
                     /translation="MTATASRITIEAMQAKYNPQVSRLIVHGFRGKFQHLTNLSDEELA
                     LFFEKLFDQFPAEAASRRIVALQEGQVLGTLSIKWNADSGKKQENRKLPSWRSFHSIGT
                     WDFLKLLIGLSLLDHQPQAGECYIADVAVHPDHRSKGIGKMLLEWAQQLVHAEPSLNML
                     SLHVSGKNPRAKHLYEQLSFYTHSQGNSIMRHFLFNERKWHYMILRLK"
     gene            4231..5244
                     /locus_tag="L3476_RS06680"
                     /old_locus_tag="L3476_06670"
     CDS             4231..5244
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016742652.1"
                     /locus_tag="L3476_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06670"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_272827667.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 9.8e-11, bitscore:
                     39.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKIMTSMIIIVLLFGGAGLYILRQNTFNMVEQAVEIHTPQGKL
                     TGTFVLPKHYLDKLGLVLFIHGDGPIDASHDDGYKPLWERLASLGYASLSLNKRGINGS
                     EGNWLHQSIDDRVEEARQAIAWAQQQPMIDEKQIGVWGASQAGWVIPKLAKKEPLAFSL
                     LLSPAINWLSQGQYYTRIEMKNDGYSEAEIKDKEAYDRQVRKLLEKQASYEEYVKIARE
                     NSLMSKDRWTFVSKNFLSDATDDLRNFNTPVLLIMGEEDLQVDVKKTERVYRDIVQHDL
                     LTVAVFPDADHSMLSKQTANSNLRALFISLFAPRQITIPGYMDEIEQFLKKLPKHT"
     misc_feature    4254..4269
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.04"
                     /tool="antismash"
     gene            complement(5372..6259)
                     /locus_tag="L3476_RS06685"
                     /old_locus_tag="L3476_06675"
     CDS             complement(5372..6259)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019422164.1"
                     /locus_tag="L3476_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06675"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_272827669.1"
                     /sec_met_domain="Abi (E-value: 1.2e-08, bitscore: 33.6,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLRKNQNMKWLCLLLAGWSTLVVGLFLGALSGYVAGQLFDLSTN
                     SKLFVQGIVMSGLVVPLILYLYPHVYKITGVTPTTPVYSWKRLPHFMTGVLLAIALASS
                     GFIIASSQGWIVMGKWHTPDQWLTALLINVIIAFLYEALPEEFGLRGMLYDLLRHRFAA
                     WLAVLFQIILFILVPITVTQLQVLFGLAPGNIINMPYIIIILSFGICLQLLRLWTGSLW
                     ASIGFHLAYLEIMRFAIPPYGVPPIITFHESAPGLSHSLSISMMIIGGIIVSLVILGAR
                     RFIRSEITGSRPYR"
     gene            complement(6372..7244)
                     /locus_tag="L3476_RS06690"
                     /old_locus_tag="L3476_06680"
     CDS             complement(6372..7244)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676096.1"
                     /locus_tag="L3476_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06680"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_272827670.1"
                     /sec_met_domain="Abi (E-value: 9.7e-09, bitscore: 33.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKWILLVLAGWSTLVVSLFLAGLAGDAANQLLGLSGNSRTFV
                     QGIVMSGLVVPIILYLYPHVYKITGATSKPSVYSWKRLPHFITGVLLAIALASLGFIIA
                     SSQGWIVMGKWHTPDQWLAALLTNVIIAFLYEALPEELGLRGMLYDLLRHRFAAWLAVL
                     FQIILFILVPITATGLQVLFGLAPGNIINMPYIILILSFGTCLQLLRLWTGSLWASIGF
                     HLAYLEIMRFVILPHQYGGPIITFHESVPGLVGLFTMIMIIVGGIIVSLVILGAKRFIR
                     KSERRHTTA"
     gene            complement(7299..7925)
                     /locus_tag="L3476_RS06695"
                     /old_locus_tag="L3476_06685"
     CDS             complement(7299..7925)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676097.1"
                     /locus_tag="L3476_RS06695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06685"
                     /product="ABC-2 transporter permease"
                     /protein_id="WP_272827671.1"
                     /transl_table=11
                     /translation="MLNLLRKDFIALKSSLGVLIICLAVFSIAFIPKHDMSLFTVGFTV
                     AIVALNMSTLIDIRNHNHNFLVTLPIKRKHIVLAKYITTIITTLCGVLASYGIHLLVTL
                     AFPQLIKPDYSFLGLFVLPGVMLVFISIYMPFFYTFSKKGAEIINVVSIIVLFALMNPL
                     VMLMSMMNDDSFISSQILFLISIGILLLLIVSYYLTVHLFTRKDL"
     gene            complement(7918..8784)
                     /locus_tag="L3476_RS06700"
                     /old_locus_tag="L3476_06690"
     CDS             complement(7918..8784)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676098.1"
                     /locus_tag="L3476_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06690"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_272827672.1"
                     /transl_table=11
                     /translation="MNAIELRNLTKTYPEFTVDQVSLDVKQGYITGLIGPNGVGKSTLI
                     KMMIGLIRPDSGSVKILGCDMPNQEIDIKQRIGIVSDDCFYYEHLTICDTKRMIAPFYK
                     KWNEKKFNSYLEQFELSPKKKIKELSKGMKVKLSLAVALSHEAELLIMDEPTSGLDPVF
                     RRELLDLLADMMQDERNSIIFSTHITTDLDRIADYIAFINRGKLVFNEAKDEVLDRYAI
                     VKGDSQLLDSDIRNKFVGIRETAVGFEGLVDNRQEAEHLFGNYAVFEKPSLEEIIYFTT
                     KGGRIHA"
     protocluster    8583..20484
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[13582:15484](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(13583..15484)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            complement(8781..9113)
                     /locus_tag="L3476_RS06705"
                     /old_locus_tag="L3476_06695"
     CDS             complement(8781..9113)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005550804.1"
                     /locus_tag="L3476_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06695"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_240927484.1"
                     /transl_table=11
                     /translation="MNQIRQSILSGELQAGDSLPSIRQLAKDLQVSVITTKRAYEELEK
                     EELIDSVVGKGCFVSGANKEFIREQRMKRLEEKMLEIIRDSKELSMSQQDVIEHLTLLF
                     EEEQTP"
     misc_feature    9198..9216
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.17"
                     /tool="antismash"
     misc_feature    complement(9207..9225)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 28.36"
                     /tool="antismash"
     misc_feature    9210..9228
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.9"
                     /tool="antismash"
     misc_feature    complement(9241..9253)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            9501..9908
                     /locus_tag="L3476_RS06710"
                     /old_locus_tag="L3476_06700"
     CDS             9501..9908
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_06700"
                     /product="hypothetical protein"
                     /protein_id="WP_272827673.1"
                     /transl_table=11
                     /translation="MTYHQPFVQNPAGFQGSAPSEQALAQPIIQIRPRDDVFHESHSTW
                     HHIPHHHEHHPGMCHPWGDVMVHPWEHSHDPSMIHPFMHHPWDPHMDDFHPYLSSGWDC
                     CPVDYHYDWFHPCPWDHPHAHGHHSWDSHHW"
     gene            complement(10001..11593)
                     /locus_tag="L3476_RS06715"
                     /old_locus_tag="L3476_06705"
     CDS             complement(10001..11593)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419011.1"
                     /locus_tag="L3476_RS06715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06705"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_272827674.1"
                     /sec_met_domain="PF00881 (E-value: 9.3e-07, bitscore: 27.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLMNLDDFLHRLQYDPDKVKPLDWETDWDDAPLPYKLYRGLPMF
                     PLSREVPATLEGRDTPGVPSLRDIGHFLYYVYGLAQLTQSVMERDPSEESGGVLQMCRR
                     FVASGGGLYPSELYLYLKLGELPAGVYHYDAAHHRLALLREGNFDDFLARSLGNRCDAN
                     GCFGAAFVSTVYWKNFYKYNNIAYRLQGLDAGVLIGQLLEVAKRFGFSSSVHFQFLDQA
                     INHLLGLSEQEESVYAVIPLSTEPAIRWVESGREEEDMDSASDLCRELSPISHDHYVRS
                     RRIADYPLLLRMSDASRLDSARLFRQIRQEEQALPDQALTLPLPPVDRLSYDLAAVCRN
                     RFSPETEFVLKPIGLSRLAALLREATASFTYRNDLDGLQERPEPRVCLYGCFYGVEDVP
                     DGAYRYDGATHSLQSVCLGDHRQRMQEGMPLPNINLSQVPLCLHVAGKRGFLQSQLGKR
                     GYRIQQMEAGMLVHRLLLAASALGMGGRPLLAFDANSSDALYRTAARDEAGLIFIPVGP
                     YRQRLRLAGSLIR"
     gene            complement(11636..13586)
                     /locus_tag="L3476_RS06720"
                     /old_locus_tag="L3476_06710"
                     /pseudo=""
     CDS             complement(11636..13586)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419012.1"
                     /locus_tag="L3476_RS06720"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06710"
                     /product="TOMM precursor leader peptide-binding protein"
                     /pseudo=""
                     /sec_met_domain="TIGR03882 (E-value: 1.9e-47, bitscore:
                     159.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAIVTVIGEGQLADFVRKLLSADDRYRLVWQKSIESGETAMGDL
                     ALVLNDAWDPSVHPAAEERFRQTGTPWLRGFVAFGEGIVGPLVRPEEQGCSQCADTRLL
                     LAGSDRRESWGLQQKLASHGGIARDAWASRTGLLQVAHLVAAEAVKILESVRPETDSRM
                     YLIDLQTLQSSSHFFLPDPLCPICSRLPEDDAQLARITLQPSLKISAKTYRSRSLDELK
                     DVLAKDYLDARTGFLNGKMVDLVSPFADASINLPLFGGDEACAGRTHSYADSEMTAILE
                     GIGALLRSVAPRQTNRRS"
     gene            complement(13583..15484)
                     /locus_tag="L3476_RS06725"
                     /old_locus_tag="L3476_06715"
     CDS             complement(13583..15484)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419013.1"
                     /locus_tag="L3476_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06715"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_272827675.1"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     6.5e-48, bitscore: 159.1, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="TIGR03693 (E-value: 7.2e-205, bitscore:
                     680.3, seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 5.2e-12,
                     bitscore: 44.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPSVRLKVKGDTFFLPDSNGGVYFRNNTGSFRMEGDMVDRWIEK
                     LMPMFSGEYSMADLTDGLPEPYRLRVYEIAEVLLNNGFVRDASQDRPHSLPEAVERQYA
                     AQIEFLDSLGGSGAYRFQTYREANPIAVGSGPIFVSLVAALLESGLPRFRMLITNRAAT
                     DRQRISELTATARLSDSEVEVEEICPSDDGSLDWREIVRLADTVLYVAQDDDPGELRAL
                     HAACRDAKKLLVPAIYLRQAGIAGPLVHPDSDVCFESAWRRIHRIALGDSDHPTAVSTT
                     AEAMLANVVVFEWLKTVSGATSELNGQLFLLNPETLEGEWHSVLPHPLVRGLRPAEPTD
                     PFCLPANQGTARQEADRLLSYFYRLTSAKTGILHRWEEGDSKQLPLSQCRVQAVDPLSE
                     GPAELLPQIVCMGMTHHEARREAGLTGIEAYVSRLAGELQEYVGIGAGETVAEAILRGL
                     RKCLFEELKSRSDSSLPFVYRTTLSKVEDDFCRYCLRALETMQDAPVIGLGQEAAGFPV
                     IWVGTNGYWYGGVGVNRTMALREALRQALMTIQNDAADIQGHILERSSVKVEDALPQSL
                     TIPGFDESEYGMMLQSVRQILQGNRKRIAVVDLSTEPFMKKELAGVFGVSLREEETH"
     aSDomain        complement(15200..15481)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3476_RS06725_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.10E-50"
                     /identifier="RREFam011.1"
                     /label="L3476_RS06725"
                     /locus_tag="L3476_RS06725"
                     /protein_end="95"
                     /protein_start="1"
                     /score="159.1"
                     /tool="antismash"
                     /translation="NPSVRLKVKGDTFFLPDSNGGVYFRNNTGSFRMEGDMVDRWIEKL
                     MPMFSGEYSMADLTDGLPEPYRLRVYEIAEVLLNNGFVRDASQDRPHSL"
     aSDomain        complement(15227..15472)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3476_RS06725_Thiopeptide_F_RRE.1"
                     /evalue="2.50E-14"
                     /identifier="RREFam004.1"
                     /label="L3476_RS06725"
                     /locus_tag="L3476_RS06725"
                     /protein_end="86"
                     /protein_start="4"
                     /score="44.0"
                     /tool="antismash"
                     /translation="VRLKVKGDTFFLPDSNGGVYFRNNTGSFRMEGDMVDRWIEKLMPM
                     FSGEYSMADLTDGLPEPYRLRVYEIAEVLLNNGFVRD"
     gene            complement(15559..15771)
                     /locus_tag="L3476_RS06730"
                     /old_locus_tag="L3476_06720"
     CDS             complement(15559..15771)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_06720"
                     /product="hypothetical protein"
                     /protein_id="WP_272827676.1"
                     /transl_table=11
                     /translation="MQQLFPLQQLLQLLPLRWLRALRKLRSLPLNTDKLAWRTAKTACP
                     CRCIVLQGLFLFFVPGMKDKTIYIT"
     gene            complement(16291..17682)
                     /locus_tag="L3476_RS06735"
                     /old_locus_tag="L3476_06725"
     CDS             complement(16291..17682)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="L3476_RS06735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06725"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_272827677.1"
                     /transl_table=11
                     /translation="MNKLGRKLFISILVSVLLIFVIFVLLANLFMPKYYIYKTKEQLRE
                     AINTINRLSEAEWIEAIPQIEQQYRVTIVYDDLQKRENDLNESLKQQLAKKRVTLNKFW
                     ITDESRLKVKAGTRINEIYDQGKLKSSFYASFIPKDETIVLIGLSMAYISDTVGMINEF
                     ILILAFCSVLIIVFVVWILSYRMTKPLKELGQVAKDISELRFRRARVDTRDEIGELAES
                     INTMSDKLSAAHAELSRKNLSLKRFMSDMTHELKTPVSLIQAYAEGIQDGLDDGSYPTT
                     ILRHNESMARLINEFLNFAKIERDELEFRPVAVKDLFQECAGKFGIELRSRNLQLVIRD
                     ELPGNPLIAADPDKIRMVFQNLLGNAVKYAAGERIDVVFEKQDTEMVLHMSNSLPREIS
                     DASRLWEPFYVEESSRHKEMSGTGLGLTIVKTILERHGFRCHVETKEETIHFYIYFKVN
                     SPRSA"
     gene            complement(17675..18322)
                     /locus_tag="L3476_RS06740"
                     /old_locus_tag="L3476_06730"
     CDS             complement(17675..18322)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866097.1"
                     /locus_tag="L3476_RS06740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06730"
                     /product="response regulator transcription factor"
                     /protein_id="WP_272827678.1"
                     /transl_table=11
                     /translation="MRILIADDEQDMLRILTAYFKKEGYEVFTAENGEEALDVFYREKV
                     DLSILDWMMPKVSGIEVCRAIKARSDKKVLILTAKSEEEDELRALSIGADEYIRKPFHP
                     KILVHRAKKLLGDEKGLHYQSLRIDPEGNKIYKDGVDLGLTKMEFELMCCFVRHKAQIL
                     SRQQLLDLVWGLDYFGDPRTVDTHVRRLREKVGEDVIKTHRGLGYSVEAGDE"
     misc_feature    18437..18454
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 18.9"
                     /tool="antismash"
     gene            complement(18541..18747)
                     /locus_tag="L3476_RS06745"
                     /old_locus_tag="L3476_06735"
     CDS             complement(18541..18747)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS06745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_06735"
                     /product="hypothetical protein"
                     /protein_id="WP_272827679.1"
                     /transl_table=11
                     /translation="MKPFLGGFACPIILTLLVMLGLTTMPKAMTLFSKKQRTSLKVFFL
                     STFVGTELHVLMDKIAINGWITF"
     misc_feature    18946..18958
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            complement(19062..20171)
                     /locus_tag="L3476_RS06750"
                     /old_locus_tag="L3476_06740"
     CDS             complement(19062..20171)
                     /GO_function="GO:0050511 -
                     undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012748953.1"
                     /locus_tag="L3476_RS06750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06740"
                     /product="undecaprenyldiphospho-muramoylpentapeptide
                     beta-N-acetylglucosaminyltransferase"
                     /protein_id="WP_272827680.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 4e-25, bitscore:
                     86.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 6.9e-26,
                     bitscore: 89.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRRIVLTGGGSAGHVTANLVLISRLLEEDWDITYIGSKNGIERE
                     LVAGFKGLQYNPISTGKLRRYWAWANVTDLFKLMIGIIQAFLLISRIKPDVVFSLGGFV
                     AVPVVVGAALKRVPVIIFEPDLHPGLANRISRKFARAMCTTFRETVDNDGNDDGKMVYA
                     GPIVREELKLGSRVRGMRLCSFFEDKPIILVMGGSQGAERINHAVRETLRELLKSYQVV
                     HICGIGKTNAAYRRYQGYIQLEYAREELPDLMAMAELIVSRAGSNAIHELLLLRKPMLL
                     IPHSIGGARTGQTLNAENFKDAGYSEVLYETDLTKEALLKAIDSTYRNQKSYVDRMKAS
                     KTDGAVDKVMALIEMAVKGKEGQRVEDVS"
     gene            complement(20168..21145)
                     /locus_tag="L3476_RS06755"
                     /old_locus_tag="L3476_06745"
     CDS             complement(20168..21145)
                     /NRPS_PKS="Domain: NAD_binding_4 (7-127). E-value: 1.9e-12.
                     Score: 38.8. Matches aSDomain:
                     nrpspksdomains_L3476_RS06755_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018670264.1"
                     /locus_tag="L3476_RS06755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_06745"
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="WP_272827681.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.1e-14, bitscore:
                     52.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2e-93, bitscore:
                     311.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDSTILITGGTGSWGVELVKQLLVKEPKEIRIFSRNESLQVHMR
                     RQFGDSRLRFVIGDIRDRAELAMACSGVDEVYHLAALKHVPICEEQPESALKTNVIGTQ
                     NVIEAAIENSVRKVMYVSTDKAANPANIYGMTKAIGEKLILCANGRSDTRFVSFRSGNV
                     IGTTGSVVPLFIQQLKEGRDLRVTAPGMTRFFLTVEDAVQILVTAMENSLGGEIFVPKM
                     GACRITALAQALINHSNSKHAKIHYVGIRSGERLHETLITESESSRVNESHERYFVIMP
                     DVQSDSLAVDEVHRGDIRRGYHSQDCMMSLDEIGPLLRKGGFVE"
     aSDomain        complement(20765..21124)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3476_RS06755_NAD_binding_4.1"
                     /evalue="1.90E-12"
                     /label="L3476_RS06755_NAD_binding_4.1"
                     /locus_tag="L3476_RS06755"
                     /protein_end="127"
                     /protein_start="7"
                     /score="38.8"
                     /tool="antismash"
                     /translation="ITGGTGSWGVELVKQLLVKEPKEIRIFSRNESLQVHMRRQFGDSR
                     LRFVIGDIRDRAELAMACSGVDEVYHLAALKHVPICEEQPESALKTNVIGTQNVIEAAI
                     ENSVRKVMYVSTDKAA"
     CDS_motif       complement(21038..21133)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L3476_RS06755_0001"
                     /evalue="1.20E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="L3476_RS06755"
                     /protein_end="36"
                     /protein_start="4"
                     /score="11.6"
                     /tool="antismash"
                     /translation="TILITGGTGSWGVELVKQLLVKEPKEIRIFSR"
     misc_feature    complement(21200..21215)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(21319..21336)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.69"
                     /tool="antismash"
     misc_feature    22207..22222
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.24"
                     /tool="antismash"
     misc_feature    23482..23497
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.61"
                     /tool="antismash"
ORIGIN
        1 gttgctcccg tggcacctgt agctccagtg actccggtgg ctccagtgtc tcccgtggca
       61 cctgtagctc cagtgactcc agttgctcca gtgactccgg tagctccagt gactccggtg
      121 actcccgttg ctcccgtggc acctgtagct ccagtgactc cggtggctcc tgtggcacct
      181 gtagctccag tggctcctgt cgctcccgtt actccagtgg ctccagtgtc tcctgtgact
      241 ccagtcgctc ctgtagctcc agtgactcca gtggctccgg tcactccagt ggctccagtg
      301 tctccagtgg ctccggtcac tccggtggct ccagtcgctc cggtttctcc tgtagctcca
      361 gtcactccgg tggttcctgt tgctccggtg gttcctgttg ctccggtggt tccagtgact
      421 ccggtggctc cggtgactcc agtggctccg gtcgctccgg tggctcctgt tactcccgtg
      481 actcctgttg ctcctgtcgc tccagttgct ccagttgctc cagtttctcc gattgctcca
      541 gttgctcctg tggctccggt agccccggtg actcccgttg ctcctgttac tccagttgca
      601 cccgtggctc ctgtcactcc cgtggcccca gtgtctccgg tcgctcccgt gactcctgta
      661 ggtcctgttg ctccagtgac tccagtggcc cctgtggccc ctgtagctcc agtgactccg
      721 gtagttcccg gtgttcctgt agctccggta gctcctgtcg ccccggtggc tcccgttgga
      781 ccagtggctc cagtggctcc tctaggtaac aagggaaaaa tagttcgaca gttcttcggg
      841 ggccttaaag aagaagggag ggagtttaga ggataaaatt tgacgttcat aaacaaaccc
      901 ctttttaaga ggagattaga ggagattaaa tcaagctttc atcgtttcga atatattatg
      961 caggttagca gttcaatgta catttttccc ttgttgagaa tccacctttt cgtaggtact
     1021 ggttagccga atgtctttgg ctaagttttc cactcgacac atgtctgaga gtcggaactc
     1081 gtatgagaac gctgctatgt tttttcggtc caccacgtca gcggcattcc tcatactttt
     1141 ctcaacctac tctaacataa caagtgctcc ccctaagcat cgagaaagaa gtaaaggcag
     1201 taacgtggcc ataacctcaa ccgactactc tcatgtactt cttgtccatg ataaccccct
     1261 cccttcttct atggtgagct atacttacct cgataacctc aaaatcccta tttcttatta
     1321 aacaaaaacc cggaaaacag ccactctttt tcaaaagtgt ctatcttccg ggtgacatga
     1381 ttttattttt tgttatctac aggaatcgaa attttcttat tgtaggtttt aatataatgg
     1441 aatccgtcca gcagcaggaa ttccggtgtc tccgtggtgt taaacgaata cgtctgctcc
     1501 cacagagtgt taccgttctt cggatcccaa gggcgtgctg tggaaagcga tgatacggga
     1561 actacgatac caccagcttt tatggatata agctccttta tccactttac aaattgtttt
     1621 ctggtgataa cgatatcatg gcctgtatcg gttttggtta cgcttcgaat ccataacttt
     1681 tcgtcaccta ctgtgatgga acgatctgat ggcgaggcaa gcgaaatagg ttcttctagt
     1741 tgtgtgataa gctccgaaat gtacgaattc aagctttttt tctgaaaatc tcggggattc
     1801 ctctacttca taatgcgtct ttccgatggt cgaagttggc gaaggggtaa tggagtcata
     1861 gtggacagtc cctgatcgac agcgatgaat ttgaaatatc cgctttaatc atactgaatc
     1921 agtacagaac cctgtaatac atgagcaatg cattatcgtc ctcaacaaca ccattaatgg
     1981 taatgactgg tcatgaagcg cggtgctttt gtctacccgt tgcccgtaga taattgatta
     2041 ttcattattt gatcttcctg ttcttacgct tacggatgag agttcccttg aaaatgtcca
     2101 tcatgccgct gcgtgaagca taacaagata atcgtgccgc gctttataaa aggtagtaat
     2161 cttcatcatt caataatcac tcagatgctt atctgttata atcattccct tctgcacgaa
     2221 ccactatcat ctttaataat agccggagag cttctttaat accacaaggc ttaggaagtg
     2281 gtggtataaa acatgcctga tcttggcggc tgtttcattg caacagaatt tcattttgag
     2341 tcgaaatctt aatcattgga atcgggtgaa atcacatccc actttccaaa cagcgtcaaa
     2401 cccgccgctt tagcgagaga cgcagacgcc aggttatcga gctggtatcg atactgaggt
     2461 tcgtatcctt gttcacaagc gtacttaact gatggaacgc accactttgc gggcgtgacc
     2521 ttttcctcgg aagggcgtca gagtcagtac gccgagatcc gcaatttgcg cattgtccca
     2581 gggatacatg ctggcggcgc taaccaagcg gtgttcctca aaagagccga acaccgccca
     2641 gcccagttat ccaattccac ataagcgtca tccatttatt cgtattgggc taattcattt
     2701 ttatgcaaac acttgacctt aggtctgacc caaggtgtat cgttgagtta ttccaagctt
     2761 tatcacttag gagtgaacga gatgaaaagt gaaattacca ttagtgaatt agccaagctt
     2821 atgaacgtgt ctgttcacca aattcgttat tttgaagaga aaggagttct tcagcccagc
     2881 tacacagata acaatcagta tagaatgtac ggcatcgagc aagtatacga gctggcgcat
     2941 attctattgc ttcgcaagct gggagtccct gttccatcca ttaaggaatg catgacttcc
     3001 tttactgcgg atcaatttcg acagcttctt cattcttccc tacgagatat agagatggag
     3061 cagcagcgtc tcatggagct tcaacagttc attaccaaag tgctgcagga acagcacaac
     3121 gtaactacac ggtccaaccc gtaccaaatc aagcggcgag acaccaccta ttttgtgcgc
     3181 tggctggaga tggatttccg cacgaagctt actgccaaac gattagctga tcacacgaag
     3241 cgcattccga acttgttcga aatggatatt cattatatat atgacggttc acacatcaac
     3301 gcgttgtgcc tggaagcaca agaacctggc gatttttgtt tgcctgaggg agattacctg
     3361 tcgatgcagt gctccactca ggaagaggat gagcttgaac aagttattga acagttctac
     3421 gactatgctg ctgcacaatc ttatgttata tcagggcccc tagtcctcat cgaaaaatct
     3481 tatttatctc tctttatcaa ccacaagctt caatacgagc tgcaagtctt gatagagccg
     3541 gtgacaaatc cgtaggaggg aatgatcatg actgccactg cctcacgaat aacgattgaa
     3601 gcgatgcagg ccaagtacaa tccacaggtt agccgattga tcgttcacgg gtttcgcggg
     3661 aaattccaac acctgacgaa cctgagcgat gaagagcttg ctcttttttt cgagaagctg
     3721 tttgatcaat ttcccgctga agcggcaagt cgaaggattg tcgctctgca agaggggcaa
     3781 gttctcggaa ctctgtctat caaatggaat gcggattcag gaaaaaagca agaaaataga
     3841 aagcttcctt cgtggaggag ttttcacagc attggaacgt gggactttct taaactgtta
     3901 attgggctct ctttattaga ccatcaaccg caagctgggg aatgttatat tgctgacgtt
     3961 gctgtccatc ccgatcatcg aagcaaggga attggaaaaa tgctattgga atgggcacag
     4021 cagcttgtcc acgcagagcc aagcctaaat atgctaagcc tgcacgtctc gggtaaaaac
     4081 ccgcgggcca agcatctgta cgagcagtta tccttctata ctcattcaca aggaaatagt
     4141 atcatgcgtc attttttgtt caatgaaagg aaatggcact atatgatcct gagattgaaa
     4201 tagttgagac acttcacaag gagaactaag atgaaaaaga aaattatgac ttccatgata
     4261 atcatcgtcc tgttatttgg aggtgcagga ctttatattt tgcggcaaaa cacctttaac
     4321 atggttgaac aagcggttga aatccatacg ccacaaggaa aattgaccgg cactttcgtg
     4381 ctgcctaaac actacttgga caagctggga ctggttttgt ttattcatgg ggacggcccc
     4441 attgacgcct cccacgatga tggctataag ccgctgtggg agcggttggc atcccttggt
     4501 tacgcctctt tgtcccttaa caaaagagga attaacgggt cggaaggcaa ctggctgcat
     4561 cagagtatag atgatcgtgt ggaagaagcc cgtcaggcca ttgcatgggc acaacagcag
     4621 ccgatgattg acgagaagca aatcggggtt tggggagcaa gccaagcggg ttgggttatt
     4681 cccaagcttg ccaagaagga accgctcgca tttagcctcc ttctatcgcc cgcaattaat
     4741 tggttaagtc aaggacaata ctatacacgc attgaaatga aaaacgatgg atactccgaa
     4801 gcggagatta aagacaaaga ggcgtatgac cggcaagtgc gcaagctttt ggaaaaacaa
     4861 gcttcctatg aagagtatgt aaaaatagct cgcgaaaata gcctcatgtc aaaagacaga
     4921 tggacatttg tcagcaaaaa tttcttatcg gatgccactg atgatcttcg taatttcaat
     4981 acacctgtgt tattgattat gggcgaagaa gacttgcagg tcgatgtgaa gaagacggaa
     5041 cgggtatatc gcgatatcgt acaacatgat ctgctgaccg tagctgtctt ccctgatgcc
     5101 gatcattcca tgttaagcaa gcaaacggcg aattcgaatc tgcgggcact cttcattagt
     5161 ctcttcgctc ccagacaaat tacgataccg ggttacatgg atgaaatcga gcaatttctg
     5221 aagaaacttc ctaaacacac ataatcagaa aaggatgctc ttcacgattt cgaagaccat
     5281 cctttttata cttccatatg agattaaatg atgcgtttct cagtctctat catttgagtg
     5341 gctctctttt tttatttctc gctttggaca ttcaacggta aggcctgctg cctgttatct
     5401 cactccgtat aaaacgcctc gcaccgagta taacgagtga tacgatgatt cctccaataa
     5461 tcatcatact gatagagagt gagtggctga gtccaggcgc ggattcgtgg aaggttatga
     5521 ttggcggtac gccatatggc gggatggcaa acctcatgat ttccaagtag gccaggtgaa
     5581 aaccaatcga tgcccagaga ctcccggtcc atagacgaag cagctgcaaa catattccaa
     5641 agcttagaat tattatgata taaggcatgt taatgatatt tccgggagca agtccaaaga
     5701 gcacttgaag ctgggtaact gtaataggga caagtataaa tagaataatt tgaaataaca
     5761 ccgctagcca agccgcgaat cgatgacgta agagatcata cagcatgcct cgcaatccga
     5821 attcctctgg taaagcttca tatagaaaag caatgataac attgataagc agcgcagtaa
     5881 gccactgatc gggggtatgc cattttccca tgacgatcca cccttgagaa ctggctatta
     5941 tgaaacctga tgaagccagt gcaatggcca agagaacccc agtcataaag tgaggcagtc
     6001 ttttccagga atatactggt gttgtgggtg taacaccagt tatcttatag acatgcggat
     6061 acaaatacaa aattagcgga acaaccagcc cgctcattac tataccctga acgaacaatt
     6121 tagaatttgt tgataagtcg aacaattgtc cggcgacata accggaaaga gcacctagga
     6181 acagacccac gactaatgtt gaccatccgg ctagcaataa acataaccat ttcatatttt
     6241 gattttttcg caagagcatt acatcgcagt cctttcatta ataagatgaa tcgattcctt
     6301 ttctagaaag ttattcataa tcgcacctat taatgcaggc aggagtaatg ttacggcaca
     6361 aaatatctga atcaagcagt tgtatgtcgc ctttcacttt tccgtataaa acgcttcgca
     6421 ccgagtataa cgagtgatac aatgatgccc ccaacaataa tcataatcat tgtgaacaag
     6481 ccgacgagtc caggcactga ttcgtggaag gttatgattg gcccgccata ttgatgcggc
     6541 aagatgacaa acctcatgat ttctaagtag gcaaggtgaa acccaatcga cgcccagaga
     6601 ctcccggtcc atagacggag cagctgcaaa catgttccaa agcttagaat taatatgata
     6661 taaggcatgt taatgatatt tccgggagca agtccaaaga gcacttgaag cccggtagct
     6721 gtaataggga caagtataaa tagaataatt tgaaataaca ccgctagcca agccgcgaat
     6781 cgatgacgca agagatcata cagcatgcct cgcaatccta gttcctctgg taaagcttca
     6841 tatagaaaag caatgataac attggtaagc agcgcagcaa gccactgatc gggggtatgc
     6901 cattttccca tgacgatcca cccttgcgaa ctggctatta tgaaccctaa tgaagccagt
     6961 gcaatggcca agagaacccc agtaataaag tgaggcagtc ttttccagga gtatactgat
     7021 ggtttggatg tagcaccagt tatcttatag acatgcggat acaaatacaa aattatcgga
     7081 acaaccagcc cgctcataac aataccctga acgaacgttc gagaatttcc tgataggccg
     7141 agcaactggt tagcagcatc accggcaaga ccagctagga acagactcac gactaatgtt
     7201 gaccatccgg cgagcaccaa aagtatccat ttcttatctt tcatttgcac agcccttcct
     7261 tattattcat caccttggcc atacaactgc gcggcctcct ataagtcctt tctcgtgaac
     7321 agatgtacag ttaagtaata ggaaacgatg agtaacagta agatcccgat tgaaataaga
     7381 aataaaattt gactactgat aaagctgtca tcgttcatca tgctcatcaa cataactaaa
     7441 ggattcatca gagcaaacag gactataatt gatacgacat taataatttc agcacctttt
     7501 ttactaaatg tataaaaaaa cggcatataa atcgaaatga aaacaagcat cacgcctggt
     7561 agaacgaata agcccaagaa cgaatagtct ggtttgataa gctgcgggaa tgctagtgta
     7621 acgagcaagt gaatcccgta ggaagcaagg actccacaaa gcgtagtaat gatggttgtt
     7681 atgtatttag caagaacaat atgctttcgc tttatcggca gcgtaaccag aaaattatgg
     7741 ttatggtttc tgatatctat cagcgtactc atattgagtg cgacgatagc tacagtgaac
     7801 cccacagtaa aaagagacat atcatgtttt ggtataaaag caatactgaa tacagccaga
     7861 caaatgataa gcaccccaag tgagcttttt aaagcgatga agtctttgcg aagtaagtta
     7921 agcatgaatg cgtcctccct tggtggtgaa atatatgatt tcttctaagg agggtttttc
     7981 gaacacagca taatttccga acaaatgctc ggcctcctgc ctattatcta ctaagccttc
     8041 aaacccaaca gcagtctcgc gaatcccgac gaatttattt cggatatctg aatcgagcag
     8101 ttgtgagtca ccttttacaa tcgcgtatct gtccagcact tcatctttcg cctcattgaa
     8161 aacgagcttt ccacgattga tgaacgcaat gtagtcagca atacgatcta aatctgttgt
     8221 aatatgggtc gagaaaataa tcgaatttct ctcgtcctgc atcatatccg caagcaggtc
     8281 gagtaattcc cttctaaaca cgggatcaag tccagaggta ggctcatcca tgatgaggag
     8341 ctcagcctca tgcgataacg caacagcaag ggataacttg actttcatcc ccttggataa
     8401 ctctttgatc ttcttcttgg gagacaactc gaattgttca agatagctgt tgaacttctt
     8461 ttcgttccat ttcttataga aaggtgcaat cattctcttc gtgtcacaaa tcgtaagatg
     8521 ctcataatag aagcaatcat ccgatacaat accgatgcgc tgcttaatgt caatctcttg
     8581 gttcggcata tcgcagccta gtattttgac actcccggag tcaggacgga tcaggccgat
     8641 catcatcttg atcaaggtgc ttttaccaac gccattcgga ccaatgagac cggtaatgta
     8701 accctgcttc acatccaaag atacttgatc tactgtaaat tcaggatatg ttttcgttaa
     8761 attacgtaat tctattgcat tcatggtgtc tgttcctcct cgaacaataa agtcagatgc
     8821 tcgattacat cttgctgact catgcttagt tccttgctat ctcgaatgat ttctaacatt
     8881 ttctcttcta atcttttcat gcgctgctcc cgaatgaact ctttatttgc tcctgataca
     8941 aaacacccct tacctacaac agagtcgatt agctcctcct tctccaactc ttcataggca
     9001 cgcttggtcg tgataacact aacctgcaga tccttggcaa gctgtctaat ggaaggaagg
     9061 ctgtctcctg cttgcaattc accgctcagg atgctctgtc taatctggtt catgatctgt
     9121 atgtaaatcg ggtcgctcga tgcgttggat atgatgatgt tcaggttccc tcacctcgct
     9181 gctgtcaata gggtgcatac cgtatatata tactatatac actatatact tgtgcgtcaa
     9241 ttgaaaaatg cgaaaccatt gcttaccgcc atctttatat tcctacaaaa ataaaccaac
     9301 cagaaattct gattggccta atcatacaaa aagccgcata ttacgaggca ttggggcacc
     9361 tgcccatttt atcgggtcaa gtgccctttt ttcaatctca gcatattgta aattatgcaa
     9421 gcgaaggctt ccaaatcgag attttccaga agagggttaa caatgctttg cccctcacaa
     9481 gattaggagg aaaaccaact atgacgtacc atcaaccttt cgttcagaac ccggccggct
     9541 tccagggttc cgctccgtcc gagcaagcac tcgcgcagcc gattattcaa attagacctc
     9601 gcgatgacgt gtttcacgag tcccattcta cctggcacca tattcctcat catcacgaac
     9661 accatcctgg gatgtgtcat ccttgggggg acgtgatggt tcacccgtgg gagcattctc
     9721 acgatccgtc catgatccat cccttcatgc atcatccatg ggatccgcat atggatgact
     9781 ttcatcctta tctatcttca gggtgggatt gctgcccggt cgactaccat tatgattggt
     9841 tccatccatg tccatgggac catccccacg cgcacggcca tcattcgtgg gattcccatc
     9901 attggtaaga gaagtccggt ctcccatgct tgaaagaggg ggtttcatcg ctaacaacat
     9961 gaccgtttgc gtcaatgttg ttagcgatga ttcatttata ttaacggatc aaactgcccg
    10021 ccagccgcaa tcgttgacga tagggaccga ccggtataaa aatcagaccc gcctcatccc
    10081 gggcagctgt tcgataaagc gcatcgctgg aattggcgtc aaacgcgaga agcggacgcc
    10141 ctcccatccc gagggcggat gctgccagca ataaccggtg tacgagcatc cccgcctcca
    10201 tttgctgtat acggtatccc cgcttgccga gctgcgattg caagaacccc ctctttcctg
    10261 ccacatgcaa gcagagcggg acttgagaca aattgatatt gggaagcggc attccctcct
    10321 gcatccgctg ccggtgatct ccaaggcaca ccgactgcag cgaatgcgtg gcaccatcgt
    10381 accgataggc gccatccgga acgtcttcga ccccgtagaa gcagccataa aggcatacac
    10441 ggggttccgg ccgctcctgc aggccgtcca ggtcgttgcg atacgtgaag gaagccgtcg
    10501 cttcgcgaag cagagcggca agccgggaga gaccgatcgg cttcagaaca aattccgtct
    10561 cgggcgagaa ccggttgcgg cacaccgccg ccaaatcata cgacaagcgg tctacaggcg
    10621 gcagaggcag tgtgagcgct tgatccggga gtgcttgctc ctcttgcctg atctgtcgga
    10681 acaatcgtgc cgaatccagc cgggacgcat cactcatccg aagcagcagc ggataatctg
    10741 cgatccgccg cgacctgaca tagtgatcat gactgatggg cgacaactcc cggcacagat
    10801 cggaggcgga atccatgtcc tcctcctctc tcccgctttc cacccaccgg atcgcgggtt
    10861 ctgtcgataa cgggattacc gcatacacgc tctcctcctg ttccgatagt ccgagcagat
    10921 ggttgatggc ttgatcgaga aattgaaaat gcacgctaga cgaaaatccg aatcgtttcg
    10981 cgacttcgag cagctgtcca atcaacacgc cggcgtccag tccctgcagc cggtaggcga
    11041 tattattata tttgtaaaag tttttccagt aaacggtaga tacaaacgcg gctccgaagc
    11101 aaccgttcgc gtcgcagcga ttaccgagcg accttgccaa aaaatcgtcg aaattccctt
    11161 cgcgcagcaa cgccaaccga tgatgcgcgg catcgtaatg gtatacgccg gcaggcaatt
    11221 cgccaagctt cagataaaga tacaattcgc tcggatatag cccgcctccg gaagcaacga
    11281 agcgccggca catttgcaag acgcctcccg attcttccga tggatcccgt tccatgacgg
    11341 attgggtcaa ttgcgcaagc ccgtatacat agtagaggaa atgtccgata tcgcggaggc
    11401 tgggtacacc gggcgtatcc ctgccttcga gcgtagccgg cacttccctg gatagcggaa
    11461 acatcggcaa gccgcgataa agcttgtaag gaagcggcgc atcatcccag tccgtctccc
    11521 aatccaaggg cttgacctta tccggatcat attgcaaacg gtgaagaaaa tcgtccagat
    11581 tcatcagact catcgctttc ctccctggct tcaaccgccc agccccatat cgtaattatg
    11641 ggaacggatg cggatatgga ttaagctgct cgggcgacaa gggctccggc gaataagaca
    11701 gctctgcagg gaccctgagc actctatcca gtcccgtcac acggatgaga tgctgcccga
    11761 acgtcatcgg cagcatgccg ggaatgagta ctttcacgca atacagtccg ttgcggcgcg
    11821 tctccggagt cgtctggtcg accacgatca cttcaagatt caattgtcga aaaacatgca
    11881 gcatggcctt cagatcatcg gtcagatcgg cgttccagcc cttcggttca aacgcttcgg
    11941 cgaacgtttg tatcggacga tcgttattca acagaaaatc gagccgttcc tccgcctgct
    12001 tcaacccgta cagcatggag tggtcctcca tctgaacgac ctggtatgga tcgagaagca
    12061 tccgttcata ctgctgacgg ttttcctcga atttctcgct gaccgtaagc agcatacccg
    12121 ccacctcgtg aatcgcgctc tttgccgcgc gtatcggatc cggatgggcg cccgccgcgc
    12181 aaatgaggtt cacgccccgc tctttcttat ttttcgcgag cgcccacacg cttggtattc
    12241 catgctccat tgtcgaatta tacaaataca ggtcatagcc cgccacggcc tccaaacgat
    12301 ccgtcatcca tctcaattcc cggtccggga ccgctcggag atccaggcga ggcaggggca
    12361 gccgcgcata ccaggtcatg agaaaggagt cgcgctctac cacttcaagc atcccgtaga
    12421 agatcgcttc ctccagactg ccgcccagcg cgcagccatt tgacgtttca taaacgaatc
    12481 cgtgtccgca gcccgcactg taataggcca gcagctccgg tacgagaatc ggacgctcct
    12541 gcaggaacga atagccccat acccaatcga tcggccgttc gggatcgaag ggcttgaacg
    12601 ggaagcagga gcgttcgtac tgttccttcg catggacgcc tacgcggaga ggatcgagcg
    12661 cccggtcctg tacattgcgg aaactgtcat gaacgacggt tcgtttgccg cggggcgaca
    12721 gaccgcaata acgctccaat cccctccagg atggccgtca tttcgctatc cgcataggag
    12781 tgggttcggc ctgcgcaagc ctcatctccg ccgaacaagg gcaaattgat gcttgcatcg
    12841 gcgaaaggag acacaaggtc aaccattttc ccgttcagaa agccggtcct ggcatcaagg
    12901 taatctttgg ccaacacatc cttcagctcg tctagcgaac ggctgcgata cgttttggcg
    12961 ctgattttca ggcttggctg cagcgtaatg cgggccaact gcgcatcgtc ttccggcaat
    13021 cggctgcaga tcggacacag cggatcgggc aggaagaagt gcgaggagct ttgcagcgtt
    13081 tgcagatcga tcaagtacat ccggctgtct gtctccggcc gcacgctctc tagaatcttc
    13141 acggcttctg ccgcgacaag gtgcgccacc tgcaataatc ccgtgcgaga cgcccaagcg
    13201 tcccgggcaa ttcccccatg cgacgccagc ttctgctgca ggccccacga ttccctgcgg
    13261 tcgcttcccg ccagcaagag ccgggtatcc gcgcattgcg agcatccttg ttcctccgga
    13321 cgaaccagcg gaccgacaat cccctctccg aatgcaacaa agccgcgcag ccagggcgtt
    13381 cccgtctgtc ggaaccgctc ctccgccgca ggatgaacgg aaggatccca agcatcattc
    13441 aacacgagcg ccaagtctcc cattgccgtt tctccggatt cgatgctctt ctgccagacc
    13501 agccgatagc ggtcatcagc agacaatagc ttccttacaa aatccgcgag ctgtccttct
    13561 ccgatgaccg tcacgatcgc gctcaatgcg tctcctcctc tcgcagcgat acgccaaaca
    13621 cgcctgccag ctcttttttc atgaacggtt ctgtggacaa atcaacgacc gcgattcgct
    13681 tacggttccc ttgcaggatc tgccggaccg actgcagcat catcccgtat tccgactcat
    13741 cgaagccggg gatcgtcaga ctttgcggca aggcatcttc caccttgacc gaagagcgct
    13801 ccagtatgtg gccttggatg tccgccgcat cgttttggat tgtcatcagc gcctgccgga
    13861 gcgcttctcg cagcgccatc gtgcggttga ctccgactcc gccgtaccag taaccgttcg
    13921 taccgaccca gatgaccgga aagcccgccg cttcttgtcc cagtccgatc accggggcgt
    13981 cctgcatcgt ctccaatgcg cgcaagcaat agcggcaaaa atcgtcctct accttgctta
    14041 atgtggttcg atacacgaag ggcaggctgg aatcggaacg acttttcaac tcctcgaaca
    14101 gacatttccg cagtccgcgg aggatcgctt ccgctacggt ctctcccgct ccgatcccta
    14161 catattcctg tagttccccg gccagtcgcg acacgtacgc ctcgatgccg gtcaagcccg
    14221 cttccctcct tgcttcatgg tgagtcattc ccatacagac gatctgcggc agcagctcgg
    14281 cggggccttc cgacagcggg tcgactgcct ggacgcgaca ctgcgagagc ggaagctgct
    14341 tcgagtcccc ttcctcccag cggtgaagaa tgccggtctt cgccgaagtc aagcgataga
    14401 aataggagag gagacggtct gcttcctgcc gcgccgtacc ttgattggcc ggaaggcaga
    14461 acggatccgt gggctcggcc ggacgaaggc ccctgaccag cggatgggga agtaccgaat
    14521 gccactcgcc ttccaatgtt tccggattca gcaggaacag ctgtccgttc aattccgaag
    14581 tcgcccccga cacggtctta agccattcga atacgaccac attcgcgagc atggcttccg
    14641 ccgtagtaga gacggcggtc gggtgatctg aatcgcccag ggcgattcgg tgaatcctgc
    14701 gccatgcgga ttcgaagcag acgtccgaat ccgggtgcac caatggccct gctatgcccg
    14761 cctgtcgcaa gtagatggca ggtaccaaca gcttcttcgc gtccctgcag gccgcgtgca
    14821 gtgctctaag ctctccggga tcgtcatcct gagcgacgta taggacggta tccgccagcc
    14881 gtacgatttc ccgccaatcg agggagccgt catccgacgg acagatctcc tcgacctcga
    14941 cctcgctgtc cgatagacgt gcagtcgccg tcagctcgga gatccgctgg cgatccgtgg
    15001 ccgcccggtt cgtgatcagc atgcgaaacc ggggcaaccc ggattccaac aaggccgcaa
    15061 cgagtgagac aaatatcgga ccggaaccga ccgcaatcgg attagcctcg cgataggttt
    15121 ggaagcggta agcccccgaa ccgcccaagc tgtccaggaa ttcgatctgt gcggcatatt
    15181 gccgttctac cgcttccggg aggctgtgcg ggcggtcttg gctggcatcc cggacaaagc
    15241 cgttattgag cagtacttct gcgatttcat aaacccgtaa cctgtacggt tccggcaatc
    15301 cgtccgtcag atccgccatg gaatattccc cgctgaacat gggcatcaat ttttcaatcc
    15361 accggtcgac catgtcgcct tccattcgga acgaacccgt attgttgcgg aagtagacgc
    15421 cgccatttga atcggggaga aagaacgtat cccctttcac tttcagacgc acagaaggat
    15481 tcaagttttt tattcctcct taaggttttg ccggaggaaa aaccgcattg tacacaagac
    15541 ttcggtttcc ccccgctttt aagttatgta gatcgttttg tccttcatgc ctggaacgaa
    15601 aaataggaac agcccctgca ggacgataca tctgcagggg catgccgttt ttgcggttcg
    15661 ccaagcgagc ttatcggtat tcagcggcag cgagcgcagc ttccgcaacg cgcgcagcca
    15721 ccgcagcgga agcagttgaa gcagctgctg cagcggaaac agttgctgca tgaacaaaat
    15781 ccgccgcaaa agccggcgca aaaaaagcaa acgccaacac ataagcgggg atcacccggg
    15841 ccgcttggat tttgccccga cgcaggcgtc atccccgtcg aactgaactg gccgacattt
    15901 aagttttgca gatccttctg aaaatcgctc atttcatacc ctccgtatca ttcatttcac
    15961 tgaccctgca tgtgacaatc aatcgttaaa tgagaatgtt tcgatccggg cccgaccggc
    16021 aagctgccca tcctcaatct tgacgagata tcttatgaaa ttcgctccgc tagtgttcct
    16081 atgatatccg cccacccaaa aaaatggtta cggcagggat ccataataac tgaatttcac
    16141 tgttacgttt cgggctgtcg gaccttcgta tgaacaaaat taaaaaagca ccattaaggt
    16201 gctttaccaa ggatgaatga ttaatgcggt agcccgaaga aatatgaaaa catgctcgtg
    16261 aaataggatt ttatcaagcc ctccatctgc ttacgcagat cgggggctgt tcaccttgaa
    16321 atagatataa aaatgaatcg tttcttcttt tgtctccaca tggcagcgga agccgtgcct
    16381 ttccagaatt gttttgacaa tcgtaagccc gagacccgtt cccgacattt ctttatgccg
    16441 cgagctttcc tctacgtaaa agggctccca caatcgagat gcatcagaga tctctctcgg
    16501 aaggctgttg ctcatatgca gcaccatttc ggtatcctgc ttctcgaaaa ccacatcgat
    16561 ccgttcgccg gccgcatatt tcaccgcatt gccgagcagg ttctgaaaaa ccatccggat
    16621 tttgtccgga tccgctgcaa tcagaggatt acctggcagt tcatcgcgaa taactaactg
    16681 caaattcctt gacctgagct cgatgccaaa ttttccggca cattcctgga acaaatcttt
    16741 cacggcaact ggcctaaatt caagctcgtc cctttcaatt ttcgcaaaat tcaaaaactc
    16801 gttaatcaac cttgccatgc tttcattatg acgcaaaatg gtggtagggt aacttccatc
    16861 gtctaaccca tcctgaatcc cctcggcata agcctgaatg agcgaaaccg gcgttttcaa
    16921 ctcatgtgtc atatccgaca taaaccgctt cagactcagg tttttcctgg ataattcggc
    16981 atgcgctgcg ctcagcttat cgctcatcgt gttaatgctt tccgccagct caccgatttc
    17041 atcccgggta tcgacccggg ctcttcggaa gcggagttcc gatatgtctt tcgccacctg
    17101 tcccagttct ttgagcggct tggtcatccg atatgacaag atccagacca caaacacgat
    17161 gatcagcacc gaacaaaagg ccaagatcaa gatgaactcg ttgatcatcc cgaccgtatc
    17221 gctgatatag gccatcgaaa gcccgattag gacaatggtt tcgtcctttg ggataaaact
    17281 tgcgtaaaag ctggatttga gcttgccctg atcgtatatt tcatttatcc gggtacctgc
    17341 tttaaccttc aagcgcgatt cgtccgtaat ccagaacttg tttagggtca ccctcttttt
    17401 cgcaagctgt tgcttaagcg attcattcag gtcattttcc cgtttctgca aatcgtcata
    17461 cacgatcgtc acgcggtatt gttgctcaat ctgcgggatt gcttcgatcc attccgcttc
    17521 cgaaagcctg tttatcgtat ttatcgcttc cctaagttgt tctttcgttt tgtaaatata
    17581 gtatttcggc ataaacaggt tcgccagcaa tacaaaaatc acgaaaatga gcaagacaga
    17641 gactaagatg cttataaaca gcttgcgccc cagcttattc atcgcccgcc tccacgctgt
    17701 agccaagccc ccggtgcgtt ttgatcacgt cttcgcccac cttctcccgc aacctgcgta
    17761 catgggtatc caccgttctt ggatcgccga aataatcgag tccccacacc aagtccagca
    17821 gttgctgacg cgacagaatc tgggctttat ggcggacaaa acagcacata agctcaaatt
    17881 ccatttttgt taagcccaga tctacgccgt ctttatatat tttatttcct tccggatcga
    17941 ttcgcagcga ttgatagtgc agtccctttt cgtcgcccag cagcttttta gcccggtgaa
    18001 cgagaatctt cggatggaac ggcttacgga tatattcgtc cgcaccgatg ctgagcgccc
    18061 tcagttcatc ttcttcttcg ctttttgctg ttaaaatcaa cacttttttg tccgaccgcg
    18121 ctttgattgc ccggcatact tctattccgc tcacctttgg catcatccaa tccagaatgg
    18181 agagatcgac tttctctcga taaaaaacat ccaatgcttc ctcgccgttt tcggccgtaa
    18241 atacctcgta cccttccttt ttgaaatacg ccgttaaaat ccggagcata tcctgttcat
    18301 cgtccgcaat taatatccgc atagcaatct ccctttgtcc cttgcttcct tcaccttcag
    18361 tttgaatcgt agcggccgct tcgtccatcg tctttttatt gtcaactatc tgctgcaggt
    18421 ccattataga cacgctaagt tacatgaatg ttacgtctga attctcctaa aaagtcggta
    18481 gagaattcct tataaactaa ccccccttat gggggaagaa gaattagtaa atcgtcgcaa
    18541 tcagaaagtt atccaaccgt tgatagcaat cttatccatg agcacatgca gttcagtacc
    18601 cacgaaggta gagagaaaaa agactttcaa ggaagttctt tgctttttag aaaatagagt
    18661 cattgccttc ggcattgttg tcagtcctag cataaccagt agagtcaaga tgatagggca
    18721 agcaaaaccg cctaaaaaag gtttcatccc gtccccctcc atttacaccc cccgggataa
    18781 tggaatgtaa acaaagacgt gagtcattat atcaggaaac gccattcctg caaataaagc
    18841 ggttaagttt tacaaattcc tgctcgattt gaacggatcg attacacttt aattacattt
    18901 gtgtaagact actttactga caagcttctg agttttccaa ttcaagtgac attttcaccg
    18961 acccaccaac taacgactct ttattcccgc ttccgagggc attattataa gccaacgtaa
    19021 ggacaatcag gacgagcaga gtgaaagcaa caagtaatac tttaggaaac atcctcaact
    19081 ctctgcccct cctttccttt aaccgccatc tcaatgagtg ccattacctt gtctacagcc
    19141 ccatccgtct tgctcgcctt catcctatcc acatacgatt tctggttacg ataagtacta
    19201 tctatggctt tcagtaaggc ttctttcgtg agatccgttt cataaagcac ctctgaatag
    19261 cccgcatcct taaaattttc cgcattcaag gtttgtcctg ttcgtgctcc accgatagaa
    19321 tgtggaatca gaagcatcgg ctttcgcaga agcagcagtt catggatcgc atttgaaccc
    19381 gccctcgaca cgattagctc tgccattgcc attagatccg ggagttcttc gcgggcatac
    19441 tcaagctgta tataaccttg ataccgccga taagcagcat ttgtctttcc gattccgcaa
    19501 atatgaacga cttgatagct ctttaagagc tctcggagtg tttccctgac ggcatggttg
    19561 attcgttccg ctccttggct ccctcccatg acaagaataa tgggcttatc ctcgaagaag
    19621 ctgcagagac gcatgccgcg aacgcggctg cccagcttca gttcctccct tacgatcgga
    19681 ccggcataca ccattttccc atcatcgttg ccgtcattgt caaccgtttc cctgaaggtc
    19741 gtacacattg ctcgagcgaa cttgcgggag atacgatttg caagccccgg atgtagatcg
    19801 ggctcgaata taataacggg aactcgcttt aaagcggcac ctaccacgac cggtaccgcg
    19861 acgaagccgc ccaaggaaaa cacaacatct ggcttgatcc gggaaatgag cagaaatgcc
    19921 tgtataattc ctatcataag cttaaacaga tccgttacgt tcgcccatgc ccaatatcgt
    19981 cttagcttcc ccgtactaat cgggttgtat tgaaggcctt tgaatccggc aaccagttcg
    20041 cgctctatcc cgttcttaga gccgatgtag gtgatatccc agtcttcctc taacaaacgg
    20101 gaaatcagta ctagattcgc tgtaacgtga ccagccgatc cgcctcccgt tagtacaatt
    20161 ctccgtttca ttccacaaac ccgcctttcc gaagcagtgg tccgatctca tcgagtgaca
    20221 tcatacaatc ctgagaatga tatcctctgc gtatatcgcc tcgatgcact tcatccaccg
    20281 ccaacgagtc actttggacg tctggcatga ttacaaaata tcgttcatga ctttcattca
    20341 cccggctgct ctccgattcc gtaatcaacg tctcatgaag cctttctccc gaacgaatgc
    20401 ctacgtagtg aattttggca tgctttgaat tagaatgatt gattaacgct tgggcaagag
    20461 ccgttattct gcaagctccc atcttcggga cgaatatttc gcctccgagg ctattctcca
    20521 tcgccgtcac caagatttgg acggcgtcct ccacagtgag aaagaaacgc gtcattcccg
    20581 gcgcagttac tctgagatct ctcccctctt tgagttgctg tatgaacaag ggcactacgc
    20641 ttcccgtcgt tccgatcaca ttcccgcttc taaaacttac aaaccttgta tccgatcttc
    20701 catttgcgca taagatcagc ttctctccga tcgctttcgt cataccatag atatttgcag
    20761 ggttggctgc tttatccgtg gaaacataca ttacttttcg gacgctattt tcgattgccg
    20821 cctcgatcac attttgcgtg cctattacgt ttgttttaag cgcactctcc ggctgctcct
    20881 cacagatcgg aacatgtttc agcgccgcca gatgataaac ctcatctaca ccactgcacg
    20941 ccatggccaa ttccgctcta tctcgaatat caccaatcac aaaacgcaat ctagagtctc
    21001 caaattgacg tcgcatatga acttgcagtg attcattgcg ggaaaatata cggatctcct
    21061 tcggctcttt caccagcagt tgcttgacaa gttctactcc ccaagagccc gtgccgcctg
    21121 taattaaaat cgtgctatct atcatatgtt atccctccgt tagtatttct atctgacatc
    21181 cctatcttag gtgtgttgtg ttacgccaat gtgacatata ggggcaaaca aataaaatcg
    21241 gctataatcc cccggggcca gcagtttctt catctaatgc aatccagtaa cttggcggag
    21301 aattagtagg aacgtgatgt aacactggtg taacagaagg tggctatgat tactcatgca
    21361 ttcctgagtt gattccagca tggcaagtac tagcttgaaa atatcctatc tcaaggaatg
    21421 aataattcat atttggaggt atgcacatga aaaagacgtt attaaccgta ctgtcgatcg
    21481 caatggcgtt cagtgtattc gccggaagca gtctgcctct ggccggaaag gcgggcgcag
    21541 tacatccagt gaagagcact tcaactgtgg cgtatcatga tttcaaattt aaggtggatc
    21601 cggccacctt cgatatcgtg attgaaagag gaggcgtgaa ggaacatgca tctgtgccgc
    21661 tgaagccccg agccgtgcgc gatgtgaaga aaacagcgaa ccgaatggaa tggacgtacc
    21721 ccgatgacaa agtcaacgtg gtcgttcaga aaaaaaacca aaaatatctg gacattcgta
    21781 ttgaatccat cggagcagaa caatttgctt ggccgaccgt gcaagccgac agttatatgc
    21841 tgcctctcgg ggaaggcaag cggattcccg ccaatgatct caactggaag cagttcctga
    21901 atggagaaac gatgacatgg ggcgaatctt tctcgatgaa ctttatggcc ttgaacaaaa
    21961 agcattactc cctgctctat atcgtagaga atccgttcaa taatgaagta gcgttccggg
    22021 cagagcctaa gctcgatatg acattccaac acgaatttcc atccatcaat ccgaaaaagg
    22081 agtatagctt ccggctgtac attaccgaca acgatcccgt ggccgtcgcg aagctgtaca
    22141 aagaatatgt gaaggagcag caaggcttta agacgctggc cgataaagcg aaggataacc
    22201 cggaaatcga aaagctgttc ggggcgccgc atatttatat gtggaacagt caggtgcttg
    22261 aggccgacaa tattcgctgg aaaaagatga agaataagtt gaatgagccc atctggtcct
    22321 ggatcgcgga gcttgcggac cgatacgcca tggatggcgc cgatcaactg aacagcgtat
    22381 tgaaagaact aaagcaggag cagttcgtta acaactacca aaaacgggtt attgtaaata
    22441 ccctgaacca ggcgttgaag ctgaagcaac tctaccgggc cgagtatttt ccggcgctcg
    22501 atgctgccgc caagcaagct gtagctggcg gcgtggagaa gctgagtgag cagaagctgt
    22561 acgagctgaa taaaaacctg ctcaagagcg tgtttcagga cgctatcgat gatccggaga
    22621 aatggggacg cgaccagtct tctgtattgg aagaaatgcg tcagctcggc attgggaagg
    22681 catggatcgg ccttccgaac tggtcgaatg ggctcctgaa tcctgctttc gttgcgaagg
    22741 cgaaccagca gggatactta atcgggccgt atgattcgta ccactcgatt caaaagaaag
    22801 aagataagga ctggaatacg gcatttttcc cggacccgac actgtatgaa caggcaacca
    22861 tctcaaataa gaaaggcgtt aagatcgggg ggttcctcaa tcgggggcgg aagctgaatc
    22921 ctaccctttc tcttccaagc gtgaagcagc gggttgagga tattttgcag gacggcatcc
    22981 tttacaactc ctggttcatc gattgcgacg caactggaga gatttatgat gactatacgc
    23041 caggccatat cacgacacag gagcaagatc ttgcagcacg cttgaagcga atggactata
    23101 tcgggaaaga gaagcacatg gtcatcggtt cggaaggcgg taacgacttc gcgagcaaca
    23161 cgatcgcatt tgcgcacggc attgagacgc ccgtgatcaa atggggcgat aaagatatgc
    23221 gcgaaaacaa ggaaagcccg tactatgttg gcggttatgg cgctgcccaa ggcactatac
    23281 cagaacgata tgtgaagcag gtgccggtga aggagttgta tcagcatgtg tacctcgatc
    23341 ccgcctactc gctgccgcta ttcaagctcg tgtacaacga ttccgtcatt acgacccatc
    23401 actgggaatg gggcagcctg aagattaagg atgaagtcgg tgcacgtatg ctttatgagt
    23461 tgctgtacaa tgttccgccg ctttaccatt tggacagtca ggaatgggag agccacaagg
    23521 aactgatttc ttcctatttg aaagtctggt cgccgttcca cgccaaagcc gtaacacagg
    23581 aaatga
//
