LOCUS       NZ_CP094446            20876 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Paenibacillus thiaminolyticus strain Mbale2 chromosome, complete
            genome.
ACCESSION   NZ_CP094446
VERSION     NZ_CP094446.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus thiaminolyticus
  ORGANISM  Paenibacillus thiaminolyticus
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 6487160)
  AUTHORS   Hehnly,C., Shi,A., Ssentongo,P., Zhang,L., Isaacs,A., Morton,S.U.,
            Streck,N., Erdmann-Gilmore,P., Tolstoy,I., Townsend,R.R.,
            Limbrick,D.D., Paulson,J.N., Ericson,J.E., Galperin,M.Y.,
            Schiff,S.J. and Broach,J.R.
  TITLE     Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of
            Paenibacillus thiaminolyticus
  JOURNAL   mBio 13 (6), e0268822 (2022)
   PUBMED   36374038
REFERENCE   2  (bases 1 to 6487160)
  AUTHORS   Zhang,L. and Hehnly,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAR-2022) Institute for Personalized Medicine,
            Pennsylvania State University College of Medicine, 500 University
            Dr, Hershey, PA 17033, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-APR-2021
            Assembly Method :: Canu v. 08/2018; Pilon v. 08/2018
            Assembly Name                     :: PSU_P.thiaminolyticus_Mbale2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 40.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028554415.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 07:15:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,889
            CDSs (total)                      :: 5,780
            Genes (coding)                    :: 5,579
            CDSs (with protein)               :: 5,579
            Genes (RNA)                       :: 109
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 201
            CDSs (without protein)            :: 201
            Pseudo Genes (ambiguous residues) :: 0 of 201
            Pseudo Genes (frameshifted)       :: 146 of 201
            Pseudo Genes (incomplete)         :: 68 of 201
            Pseudo Genes (internal stop)      :: 17 of 201
            Pseudo Genes (multiple problems)  :: 26 of 201
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:53:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 653069
            Orig. end                         :: 673945
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094446.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bacteria and source DNA
            available from Schiff/Broach Lab, 500 University Drive Hershey, PA
            17033.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20876
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10876](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10876
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    12..25
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 19.82"
                     /tool="antismash"
     gene            805..1605
                     /gene="spoIIIAF"
                     /locus_tag="L3476_RS02965"
                     /old_locus_tag="L3476_02955"
     CDS             805..1605
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676750.1"
                     /locus_tag="L3476_RS02965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02955"
                     /product="stage III sporulation protein AF"
                     /protein_id="WP_272827299.1"
                     /transl_table=11
                     /translation="MQWFSQWLKEIIMVILLAAFIDLLLPNRSMQRYVKLMLSLIILLT
                     LLSPVLRLFDSNVTAELAREWDSLLSTSSAKSPEGKTLEQIRREGERLARAREQEALRL
                     AGAQMEASMKEQINRALLQADAAGSSGGTAVQVAALHVTLAQDARQGQLAIEQIALTLE
                     EAPATGQAAAPGPGGPPEPNPVAAIEPVRIEPIEAGTMAGSPAPGTPERAPQEAPASGT
                     GSGELLRLEAAAVGALTSAWLVKPEQITVSWSPERGLPAGAFKR"
     gene            1716..2375
                     /gene="spoIIIAG"
                     /locus_tag="L3476_RS02970"
                     /old_locus_tag="L3476_02960"
     CDS             1716..2375
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676751.1"
                     /locus_tag="L3476_RS02970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02960"
                     /product="stage III sporulation protein AG"
                     /protein_id="WP_143800912.1"
                     /transl_table=11
                     /translation="MAKWLQQIEQWIGKGSNGSTRIKAFRWLLLLGLTGAALLLYGTFQ
                     SGGGGWPKGTSNVSREPPAAGVFDGTEQSASSTPAAPGSFESVEMTFEARVKSILEEIV
                     GVGQVDVLVTIDSTEEIVVQRNFKDNQQLTDESDANGGKRHTTQHTRDGEIVMYESTDG
                     KTPIVTKRIKPKVRGVVVVAKGAENAVVKSLIVDAVEKGLNVPAYRISVVPRKIAE"
     misc_feature    complement(2385..2397)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            2425..3141
                     /locus_tag="L3476_RS02975"
                     /old_locus_tag="L3476_02965"
     CDS             2425..3141
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676752.1"
                     /locus_tag="L3476_RS02975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02965"
                     /product="SpoIIIAH-like family protein"
                     /protein_id="WP_143800911.1"
                     /transl_table=11
                     /translation="MNTKRQTIWLVSMLSLMVVLSAYYLFTEDTPKAPEMAAEQQHLKG
                     DATEATQLPQVEVTEVSVGEDAQAKAAENGMAAPEQGADPAVNVEGGQPEQGVAAPDAT
                     PEDKEQAMLDQVVAEGVMKRSTIEQKQMERNEHYQQELEKLMGMINDDKTTGDKLAQAY
                     EDMNQLEEREVKISNLETELQKDYNSAVITQNDDRFTVVVQSNKMEVTEAVDIISKMMK
                     ELNITQDKVSVQYVSE"
     gene            3295..3783
                     /gene="accB"
                     /locus_tag="L3476_RS02980"
                     /old_locus_tag="L3476_02970"
     CDS             3295..3783
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676753.1"
                     /locus_tag="L3476_RS02980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02970"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="WP_272827300.1"
                     /transl_table=11
                     /translation="MFKISEIKELIKLLDQTSVHELEIENEGCRIAIRKPGKTEVFNVQ
                     SAAPLTYPAPSPAAAAAPAEAVTAAAEPQPEKKEEQAGLIRIVSPMVGTFYSAPSPESP
                     PYVKAGDKINEKTVVCILEAMKLMNELEAEVKGEIVEVLATNGQLVEFGQPLFLVKPE"
     gene            3830..5173
                     /gene="accC"
                     /locus_tag="L3476_RS02985"
                     /old_locus_tag="L3476_02975"
     CDS             3830..5173
                     /EC_number="6.3.4.14"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004075 - biotin carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676754.1"
                     /locus_tag="L3476_RS02985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02975"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_143800909.1"
                     /sec_met_domain="ATP-grasp (E-value: 1.2e-05, bitscore:
                     23.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.8e-09,
                     bitscore: 34.4, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFHKILIANRGEIAVRIIRACRELGIATVAVYSEADREALHVRL
                     ADEAYCIGPTASKDSYLNFTNLMSVATLTECDAVHPGYGFLAENADFAEICESCGITFI
                     GPSADAIERMGDKSVAKQTMKDAGVPVIPGSDGLVEDLEQALMIARDIGYPVIIKATAG
                     GGGKGIRIAEDEGALIKQMTAAQQEAEKAFGNPGVYLEKYLTGMKHVEIQIIADKHGHA
                     VHLGERDCSVQRRRQKLVEEAPCPVLTPEVRERMGEAAVRAALAVDYSGAGTLEFLLGP
                     DGNFYFMEMNTRIQVEHPVTEMITGIDLIQEMIRVAQGEPLSFRQEDVVIDGWAIECRI
                     NAEDPARNFMPSAGQIGFYLPPGGFGVRVDSAAYPGCQISPHYDSMIAKLIVWAPTREE
                     AIDRMKRALAEFAIEGIHTTIPFHIRLLEHPAFIKGDFDIKFLEEHEV"
     gene            5285..5692
                     /locus_tag="L3476_RS02990"
                     /old_locus_tag="L3476_02980"
     CDS             5285..5692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676755.1"
                     /locus_tag="L3476_RS02990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02980"
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="WP_143800908.1"
                     /transl_table=11
                     /translation="MNQAIASEFERTDLGNIQIAPEVIAVIAGLATIEVEGVEGMSGGF
                     AGGIAEMLGRKNLSKGVKVEVGQREAAVDVNIIIEYGHRIPTVASEIQQNIKRSIEMMT
                     GLHVVEVNVHVHDVHFKSQEKVEETDPGRVK"
     gene            5768..6307
                     /gene="amaP"
                     /locus_tag="L3476_RS02995"
                     /old_locus_tag="L3476_02985"
     CDS             5768..6307
                     /codon_start=1
                     /gene="amaP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006286554.1"
                     /locus_tag="L3476_RS02995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02985"
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="WP_143800907.1"
                     /transl_table=11
                     /translation="MSKIVDRLFLFIYSFAIGTIAIAVILAASGFISQPIRLTEPFWLQ
                     STVIATAAVLFLLSIRFFYVSIRRERAALPSIDQRTEIGDIKISIETIENLALKAAGRV
                     RGVKDLKARIRTNEAGLDIVIRTVVDGETSIPELTEDVQRQVRDYVQQITGIPVSYVSV
                     YVANVVQTQTFKARVE"
     gene            6324..6554
                     /locus_tag="L3476_RS03000"
                     /old_locus_tag="L3476_02990"
     CDS             6324..6554
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676757.1"
                     /locus_tag="L3476_RS03000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02990"
                     /product="DUF2273 domain-containing protein"
                     /protein_id="WP_087442582.1"
                     /transl_table=11
                     /translation="MWNEWWESHRNRIIGIAAGIFFGVIYLIAGFWDMLFFALLVFIGY
                     NVGRQQDLKLGPMFPWRRIGLWLSERFDRFK"
     gene            6751..7269
                     /gene="nusB"
                     /locus_tag="L3476_RS03005"
                     /old_locus_tag="L3476_02995"
     CDS             6751..7269
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nusB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006039364.1"
                     /locus_tag="L3476_RS03005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_02995"
                     /product="transcription antitermination factor NusB"
                     /protein_id="WP_240927200.1"
                     /transl_table=11
                     /translation="MKRRIAREMAVQSLYQLEMTDVTPEQAVDMIVSESNQEENEIGLK
                     PEHARAMHEHVLEWVRDTWKKRDEIDALLARYLKGWQVDRLSRVDRQVLRLACYEMAFR
                     TDVPPKVAINEAIILAKHFGTEESGKFVNGVLGQMLRDRSGKQDGADASAGASGSAHSD
                     AMRQRLDPR"
     gene            7335..8210
                     /gene="folD"
                     /locus_tag="L3476_RS03010"
                     /old_locus_tag="L3476_03000"
     CDS             7335..8210
                     /EC_number="1.5.1.5"
                     /EC_number="3.5.4.9"
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /gene="folD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006286552.1"
                     /locus_tag="L3476_RS03010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03000"
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD"
                     /protein_id="WP_272827301.1"
                     /transl_table=11
                     /translation="MTAQLLNGQALSQTIREEIKQQAARLIEQGTRPGLAVIIVGDDPA
                     SHVYVNSKHKACLELGFYSEVHRLAEQTSQEELLDLVGRLNGQSTIHGILVQLPLPSHI
                     DEKAVIDAIAVEKDVDGFHPVSVGNMVLGDESLLPCTPAGIMEMLKRNDIPIAGKHAVV
                     IGRSNIVGKPISLLLQREHATVTMCHSRTQHIEELSRMADILVVAIGKAHFVNRSFIKP
                     GAVVIDVGMNRLENGKLVGDVDTDDVKELCSWITPVPRGVGPMTITMLMSNTLKSAERL
                     HRLGQASVEV"
     gene            8344..9699
                     /gene="xseA"
                     /locus_tag="L3476_RS03015"
                     /old_locus_tag="L3476_03005"
     CDS             8344..9699
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676760.1"
                     /locus_tag="L3476_RS03015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03005"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_272827302.1"
                     /transl_table=11
                     /translation="MANQARVLSVKDLNRYIRMKLDGDARLQDVWVRGEISNFTHHSSG
                     HMYFTLKDADSRLRTIMFASYNQRLPFRPKEGARVIARGNVTVYERDGQYQFYAQHMQP
                     DGIGSLYAAFEQLKERLGAEGLFAAERKRPLPRYPKKIGVITSQTGAAVRDIIITLRRR
                     QPGVHVVLYPVLVQGNQAAVSIAAAIEAMNRHQEADVLIVGRGGGSLEELWAFNEEIVA
                     RAIAQSAIPVISAVGHETDFTIADFVADLRAPTPTAAAELAVTHQEELRQHLQHLAERM
                     RHGMRRTVQQGQERLLRAQRSPVLRKPELLTAKHQERYERLLERLAYRSRSRFKQADER
                     WRELRGRLREQTPVHQVRSARERLNGIERQLHRAMAMQMNERRLKLGAHLKHLDALSPL
                     KIMARGYSLVYDEREENIIRTIRDVQLGDVVRVKLNDGQLDCHVWSMKGDSD"
     gene            9703..9969
                     /gene="xseB"
                     /locus_tag="L3476_RS03020"
                     /old_locus_tag="L3476_03010"
     CDS             9703..9969
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676761.1"
                     /locus_tag="L3476_RS03020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03010"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_272827303.1"
                     /transl_table=11
                     /translation="MDNQEKPTTQEMSFETAMEKLEHIVEQLESGDVPLEQAIELFQEG
                     MGLSGLCARKLEQVERKIEVLSEQNGELKRQPFPVEEAGDRIE"
     gene            10001..10876
                     /locus_tag="L3476_RS03025"
                     /old_locus_tag="L3476_03015"
     CDS             10001..10876
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676762.1"
                     /locus_tag="L3476_RS03025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03015"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_240927338.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.3e-62, bitscore:
                     210.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERHVARIERLLPAQFPAGWQVPAELKESMLYSLMAGGKRLRPLC
                     VVIACESLDGPLEAADPVACAIEMIHTYSLVHDDLPAMDNDDYRRGKPTNHKVFGEALA
                     ILAGDALLTHAFYTVAQCARRHGIPAEIALTITEELSFYAGMRGMVGGQTADMLGEQGM
                     TTLDQVEYIHLHKTSDLIVFALRAGAHLAGANEAQLNAMTEFGTKLGLAFQIQDDILDI
                     TGEEALLGKPKGSDEKSGKVTYPYFIGLEASKQEVARLTEEAKQAVRQAGFPYPARLYE
                     LADYLMARRF"
     misc_feature    10910..10924
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.8"
                     /tool="antismash"
     misc_feature    10959..10975
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.39"
                     /tool="antismash"
     gene            11695..12321
                     /locus_tag="L3476_RS03030"
                     /old_locus_tag="L3476_03020"
     CDS             11695..12321
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676763.1"
                     /locus_tag="L3476_RS03030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03020"
                     /product="hypothetical protein"
                     /protein_id="WP_087442586.1"
                     /transl_table=11
                     /translation="MKFSFKHSVKWSIFIFFVTFALAVILSVASTSMLGKAGWGVGMVI
                     VLMLVLIGVFFDIMGLAAAAAKETPFHAMAAEKVRGAKQAIYIVRNADRFSNFCNDVIG
                     DMTGVISGSATAIVVTNLLWSMNAESVWMTTAVSVAFTGLVSALTVGGKALGKSFAIHY
                     STSIVLLIGKCFYFLETKLHIRLLAKKRGKSKQRKRGNSRAARTD"
     gene            12302..14200
                     /gene="dxs"
                     /locus_tag="L3476_RS03035"
                     /old_locus_tag="L3476_03025"
     CDS             12302..14200
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676764.1"
                     /locus_tag="L3476_RS03035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03025"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_143800902.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 3.5e-124,
                     bitscore: 411.8, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.8e-06, bitscore:
                     25.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLEQINQPSDLKRLTKEELPVLAEEIRQFLIEKLAVTGGHLASN
                     LGVVELTLVLHYLYDSPRDKMIFDVGHQAYVHKILTGRKDRFDSLRQYKGLCGFVKRAE
                     SEHDVWEAGHSSTSLSAAMGMALSRDFKGESNKVIAVIGDGALTGGMALEALNHIGHEK
                     KNLMVVLNDNEMSIAPNVGALHNYLCKIRSDRNYLKAKEEVEQLLKKIPAIGGKLAKTA
                     ERVKDGFKYLVVSGMLFEEFGLKYFGPVDGHDIDKLIDIFQQASRVNGPVLIHVVTRKG
                     KGYTPAEADSHKWHGISPYKIESGQVLKALGNPMYTEVFGKTLVELAEQDDRVVAVTPA
                     MPGGSGLLGFAERFPSRMIDVGIAEQHAATMCAALAMEGMKPVFAVYSTFLQRAYDQVV
                     HDICRQSANVIFAIDRAGFVGPDGETHQGVYDIAFMRHIPNIVLMMPKDENELRHMLKT
                     ALEYDEGPIAVRYPRVNGVGVELDADLIPIPIGTWEMVRPGDHAAVVAIGPMVQVAEEA
                     AEQLRREGIQLRVINARFMKPLDEAMLTLLAREQLPMIVLEEGSVAGGLGSAIMEYYAQ
                     HHVFGVKVKPIGVPDCFVEHGSIKEQRQEAGLTAEQLVKEVHTMLFAHGDNRMSRA"
     gene            14233..15063
                     /locus_tag="L3476_RS03040"
                     /old_locus_tag="L3476_03030"
     CDS             14233..15063
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676765.1"
                     /locus_tag="L3476_RS03040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03030"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_143800901.1"
                     /transl_table=11
                     /translation="MSIPKERIDVLLVEQAYYDSREKAKAAIMAGLVYVNEERIEKAGT
                     KVPRDGTITVKGAVHPYVSRGGLKLEKAIRHFGLSMTDAVMLDIGASTGGFTDCALQHG
                     ARYVYAIDVGYNQLDWSLRNDERVHVMERTNFRYTEPEHLQGPAPDTATIDVSFISLKL
                     ILPPLQALIGKPGRVIALIKPQFEAGRDKVGKSGVVRDPGTHEQVLREILDFAASLGFR
                     LEGLTYSPITGGEGNIEFLAYWSVPDGGSPEPAASREQIHAVVQEANSVFRSTS"
     gene            15129..15644
                     /locus_tag="L3476_RS03045"
                     /old_locus_tag="L3476_03035"
     CDS             15129..15644
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676766.1"
                     /locus_tag="L3476_RS03045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03035"
                     /product="DNA-binding protein"
                     /protein_id="WP_272827304.1"
                     /transl_table=11
                     /translation="MNWQAPAVSVHHSGVVIPLSDIWVMGLIFIGVLIWIGFGLRTYAH
                     SPEPMEDVCLSDRFPEDEEALQLVEDAGYELIGGKFCTPLHFTLDDEEIDARIWIDMIV
                     KRDNQWYIVRIARERMKLDWDGSGMKRQWMPYFAAYPESAGLLVVDMLERRVRLIRMDW
                     GEAYVHGE"
     misc_feature    15648..15661
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 19.15"
                     /tool="antismash"
     gene            15727..16176
                     /gene="argR"
                     /locus_tag="L3476_RS03050"
                     /old_locus_tag="L3476_03040"
     CDS             15727..16176
                     /codon_start=1
                     /gene="argR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676767.1"
                     /locus_tag="L3476_RS03050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03040"
                     /product="transcriptional regulator ArgR"
                     /protein_id="WP_087442589.1"
                     /transl_table=11
                     /translation="MKGQRHIKIREIIMNNEIETQDELVDALRSAGYHVTQATVSRDMK
                     ELHLIKVPMKDGRYKYSLPVDQRFNPAQKLKRALLDNFISIDSTENLVVIKCLPGTANA
                     IAVLMDSIEWPEIMGTVCGDDTILIICRTKQQSDQVVAQIEEYIS"
     gene            16200..17921
                     /gene="recN"
                     /locus_tag="L3476_RS03055"
                     /old_locus_tag="L3476_03045"
     CDS             16200..17921
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676768.1"
                     /locus_tag="L3476_RS03055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03045"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_272827305.1"
                     /transl_table=11
                     /translation="MLIALSITNLAVIESVQLQFHQGFHVLTGETGAGKSIIIDALGLI
                     GGARGSSEFVRYGCDRAEVEASFDLPADHPAWEAVAKLGIQADAEELLIIRRELTANGK
                     SMCRINGQMVNLTMLREVGELLINIHGQHEHQSLLKVERHLDWLDAYGGEDLAALKKRY
                     REEFGCFMALQHELNQLKQTSQQAYQMLDLYRFQIEELHNANLQVGEDELLAEEKRKLA
                     NAEKLMDHVNHAYERLYGQGAMDAVSVAIAKLEDVMPYDAARFQPMVEQLQTAYYQLED
                     AAYQLRDYRENIEFNPERLEQIEDRLEQMNGLKRKYGATVEEMIAYGERIQAEADKIEH
                     KDERIAALEKESEERLAKLAKRAQALSDARRELSGKLTKRIEKQLQHLHMERTRLDVRL
                     ERLQDGQGFDVNGVNVRFTKNGWDDAEFLISPNPGEPLRPLHKIASGGELSRIMLALKT
                     IFAEMDRIPVLVFDEVDTGVSGRAAQAIAEKLAEVSRSGQVFAITHLPQVACMADHHYY
                     IEKLVRDERTSTQVTELQEQGRVAELARMLGGVEVTERTLHHAQEMLKLAERQKGA"
     misc_feature    17968..17985
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            18042..19379
                     /gene="spoIVB"
                     /locus_tag="L3476_RS03060"
                     /old_locus_tag="L3476_03050"
     CDS             18042..19379
                     /EC_number="3.4.21.116"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIVB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006676769.1"
                     /locus_tag="L3476_RS03060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03050"
                     /product="SpoIVB peptidase"
                     /protein_id="WP_143800899.1"
                     /transl_table=11
                     /translation="MNPNAKRLLGLMLAIIVCLCCTTAPFRTYAALPNHLRLFEGEHKQ
                     LNLVMPVQAQATVDRPDILKVNGQSETSFRLSLQKPISLQSSQTGQAELKLKLFGGIPL
                     KTLKVNVVPNLRVVPGGQTIGVKVKSSGILVVGHHLVHVGPDRKISPGEEAGVRLGDMI
                     MSMNGTRLNDVTKVADIVREAGEKKQAIELVIQRGDTEIKTKLKPAYDVEDKTWRLGLY
                     IRDSAAGVGTLTFYAPDQGVYGALGHVITDMDTQTPITVGQGEIVQSNVTSISKSQNGE
                     PGEKRAHFLKESRVLGNIERNTPFGIFGKMTNQPEHSLYKEPIPVAFSEEVQEGPAEML
                     TVVNGQQVERFKLEVVHVTKQTSPATKGMVIRITDPRLLQKTGGIVQGMSGSPIIQNGK
                     LIGAVTHVFVNDPSSGYGCFIEWMLQDAGVVLSPPPTSSREGSHAA"
     misc_feature    complement(19442..19460)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(19468..19481)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.36"
                     /tool="antismash"
     misc_feature    complement(19474..19483)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            19606..20424
                     /gene="spo0A"
                     /locus_tag="L3476_RS03065"
                     /old_locus_tag="L3476_03055"
     CDS             19606..20424
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /GO_process="GO:0042173 - regulation of sporulation
                     resulting in formation of a cellular spore [Evidence IEA]"
                     /codon_start=1
                     /gene="spo0A"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009591253.1"
                     /locus_tag="L3476_RS03065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3476_03055"
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="WP_143800898.1"
                     /transl_table=11
                     /translation="MQKIEILLADDNREFTNLLADFLSEQEDMVVTGVAYNGEEVLQFL
                     EQTRAVPDVLILDIIMPHLDGLGVLERLRSMNLSPQPKIIMLTAFGQESITQRAVQLGA
                     SYYILKPFDMDILANRIRQLAGVASTPSIGSSNAGSYMTSSKSNVVQLGKTKNLDANIT
                     SIIHEIGVPAHIKGYQYLREAITMVYNNIEILGSITKTLYPAIAEKYKTTPSRVERAIR
                     HAIEVAWTRGNIDSISRLFGYTINISKSKPTNSEFIAMVADKLRIEHKVS"
     gene            complement(20641..20820)
                     /locus_tag="L3476_RS03070"
                     /old_locus_tag="L3476_03060"
     CDS             complement(20641..20820)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3476_RS03070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3476_03060"
                     /product="hypothetical protein"
                     /protein_id="WP_272827306.1"
                     /transl_table=11
                     /translation="MKQKWLTNFFPVYFIAIKGEVAEWNSEHLSTTQEKEELQHEQAIV
                     EIRAFDTSYFEVVG"
ORIGIN
        1 gccgtctctt atatggttat tattattttg gccatcaaca gcttccatgt ggcgatcggc
       61 tatgcgaagg aagcgatatc gggcatgatt catttcatga tggcgatggt gccgcttctg
      121 ttcacgctgc ttgcttcgat gggcaatctc gttactgtct cggtcatgca cccgctcatc
      181 gttttcatgg tgcatctcat cggaacgcta atctataccg gcgtctttcc gctgctgttc
      241 ttctccaccc tgctgcacat tgttagcgcc ttgtcggaga agtacaaagt aacgcaactc
      301 gccaatctgc tgcgcactat cagcatcggc atgctgggcg tcctgctgac cgtcttcctg
      361 ggcgttatct ccgtgcaggg ggcgacgagc tcggttaccg acggcgtaac ggtccggaca
      421 gcgaagtata ttaccggcaa cttcgtgcct gtcgtcgggc gcgtcttctc ggatgccgcc
      481 gatacggtca tttccgcttc gctgcttgtc aagaacgcgg tcggcttggc cggggtggtc
      541 atcctgctgt tcatctgcgc gttcccggcg ctgaaaatcg tgacgctggc gctcatctac
      601 aacgtctcct ccgccatcat gcagccgctt ggcgatacgc cggcagccga gtgcctcaag
      661 acggtaggca aaagcatgat ctacgtcttc gcggcgctcg cggccgtcgg cctgatgttc
      721 ttcctggcta ttacgatact gctcacggca ggcaatgtcg cggtcatgat gaggtaggca
      781 ggggaagcga agggaggcag gagtatgcaa tggttcagtc aatggctcaa agagattatc
      841 atggtcattt tgctggccgc cttcatcgac ctgctgctgc cgaaccgatc gatgcagcgc
      901 tatgtcaagc tgatgctcag cctgataatt ttgctcacgc tgctgtcccc ggtgctgcgt
      961 ctcttcgact ctaatgtgac ggcggagctc gcccgcgaat gggattcact gctgagcact
     1021 tcgtccgcca agagccccga agggaagacg ctggagcaga tccggcggga aggggaacgg
     1081 ctggcgcgcg cacgcgagca ggaggcgctc cgactagccg gcgcgcagat ggaagcgagc
     1141 atgaaggagc agatcaaccg ggcgctgctc caggcagacg ctgccggctc cagcggggga
     1201 acggccgttc aggtcgcggc cttgcacgtg acgctggcgc aggacgccag gcagggccag
     1261 ctggcgattg agcagatcgc gctcaccttg gaggaagccc cggcgaccgg gcaggcggca
     1321 gccccgggcc ccggtggccc gcccgagccg aacccggttg cggccatcga gccggtccgg
     1381 atcgaaccaa tcgaggccgg aacgatggcc ggcagcccgg cgccgggaac gccggagaga
     1441 gcgccgcagg aagcgccagc ctctggcacg ggcagcggcg agctcctgcg cctggaggcg
     1501 gctgccgtcg gggcgctgac ctccgcctgg ctcgtgaagc ccgagcagat tacggtgtcc
     1561 tggtcgccgg aacgtggcct cccggcagga gccttcaaaa gatagccgcc gcaaaaaaaa
     1621 tgcggacaaa ccgtcataaa atcgccagcc gcgcgtatag gtgaaaatag gacaagtgag
     1681 agcaggtcca tactacgcaa aggcggtcga tagcgttggc gaagtggttg cagcagattg
     1741 aacagtggat cggcaagggc tcgaacggtt ccacacggat caaagcgttc cgctggctgc
     1801 ttcttctcgg cttgaccggc gcggcgctcc tcttgtacgg cacgtttcag tccgggggtg
     1861 gcggatggcc gaagggcaca agcaatgtta gccgggaacc gccggcggca ggcgtttttg
     1921 acggcacgga acagagcgcg tccagcacac cggctgcgcc gggctcattt gagtcggtgg
     1981 agatgacatt cgaagcccgg gtcaagtcca ttttggagga aattgtaggg gttggacaag
     2041 tcgatgtgtt ggtcacgatt gactcgacgg aagaaattgt tgttcagcgc aacttcaagg
     2101 acaaccagca gctgacggac gagtccgatg cgaacggggg caagcggcat actacgcagc
     2161 atacccggga tggcgagatt gtgatgtatg agtctaccga cggcaagacg ccgatcgtga
     2221 ccaagcgcat caagccgaag gttcgcggcg tagtcgtcgt cgccaaagga gcggagaacg
     2281 ccgtcgtcaa gtcgctcatc gtcgatgcgg tcgagaaagg gctgaatgtg ccggcctatc
     2341 gaatctctgt cgtgccgcgc aaaatcgccg agtagcaaat caacctgcat aatgcatgaa
     2401 tcgcgaagga ggagaaaaag gacgatgaat acgaaaagac aaacgatatg gctggtatcg
     2461 atgctcagct tgatggtggt gctgtccgct tattatctgt tcacggagga cacgcccaaa
     2521 gcccctgaaa tggcggccga gcagcagcac ctaaagggcg atgcgactga agcgacccag
     2581 cttccgcaag tggaagtgac cgaggtgtcc gtaggggagg acgcacaggc caaggcggca
     2641 gagaacggaa tggccgctcc ggagcaagga gccgatcctg cggtcaacgt cgagggcgga
     2701 cagccagaac agggtgtggc ggcgccagat gcgactccgg aggacaaaga gcaggcgatg
     2761 ctggatcaag tcgtggccga aggcgtcatg aagcgaagca cgatcgagca gaagcagatg
     2821 gagcgtaacg agcattatca gcaggagctg gaaaagctga tgggcatgat caacgatgac
     2881 aagacgacgg gcgacaagct ggcgcaagcc tatgaagata tgaatcaact ggaagagcgg
     2941 gaggtcaaaa tctccaatct cgaaaccgaa cttcagaaag attacaacag cgcggtcatt
     3001 acgcagaatg acgaccggtt caccgtcgtc gtgcagagca acaagatgga agtgaccgaa
     3061 gcggtggaca tcatctcgaa aatgatgaaa gagctgaaca ttacgcagga caaggtaagc
     3121 gtgcagtatg tctcggaata atgcggagtt gccgcggagt tgtcggaact ggcccggtta
     3181 aaaactgggc tctttccatt tgaggcgatt atgatataat acatacgtcg tagattgtcc
     3241 gcctgataac ataatctact tgctcataca tatcgtctca aggagtgatt caagttgttc
     3301 aaaattagcg aaatcaagga actgatcaag ctcctggacc agacatccgt gcatgaactg
     3361 gaaatagaga acgaaggctg ccgcatcgcg atccggaagc ccggcaagac tgaggtgttc
     3421 aatgtacagt cggccgcgcc gcttacatat ccagcgcctt cgccagcagc ggccgctgcc
     3481 cctgcagagg cggtcacggc agcggctgag ccacagccgg agaagaagga agagcaggcg
     3541 ggcttgatcc gcatcgtatc cccgatggtc ggcaccttct acagtgcgcc ttcgccggaa
     3601 tcaccgccgt atgtcaaggc gggcgacaag attaacgaga agacggttgt gtgcattctg
     3661 gaagcgatga aattgatgaa cgagctggaa gccgaggtca agggcgagat tgtcgaggtg
     3721 ctagcaacga acggccaatt ggtcgaattc ggccagcctt tattcctggt gaagccagaa
     3781 tgacgtatcc cgtcattcca ttacgatgcc cagccaagga ggtccaagga tgaagttcca
     3841 taagatttta atcgctaacc gcggtgagat tgccgttcgc atcattcgcg cctgccgcga
     3901 gcttggtatc gcgacggtcg ccgtctattc ggaggcggac agggaagcgc tgcatgtgcg
     3961 tcttgcggac gaagcctatt gcatcggtcc caccgcgtcc aaggacagtt atttgaactt
     4021 tacgaatctg atgagtgtcg ccacgttgac ggaatgcgac gccgtgcacc cgggctacgg
     4081 gttcctggcg gagaacgcgg acttcgcgga gatctgcgaa tcgtgcggca ttacgttcat
     4141 tggtccgtct gcagacgcca tcgagcgcat gggcgacaaa tccgtcgcca agcagacgat
     4201 gaaggacgcc ggcgttccgg ttattcccgg atcggacgga ctagttgagg atctggagca
     4261 ggcgcttatg atcgcgcggg atatcggata tcctgtcatt attaaggcaa ccgcaggcgg
     4321 cggaggcaaa ggaatccgca tcgcggagga cgaaggagcc ctgatcaagc agatgacggc
     4381 tgctcagcag gaagccgaga aagcgttcgg caatccgggc gtgtacctgg agaagtattt
     4441 aaccggaatg aagcatgtgg aaattcagat cattgccgac aagcatggtc atgccgttca
     4501 tttgggtgag cgcgactgct ccgtgcagcg gcgccgccag aagctggtcg aggaagcgcc
     4561 gtgtccggta ttgacacccg aagtccggga gcggatggga gaagcggcgg ttcgggccgc
     4621 gctggctgtc gattactccg gtgcaggcac gttggagttt ttgctcgggc cggacggcaa
     4681 cttttacttt atggaaatga atacccggat tcaagttgag cacccggtga cggagatgat
     4741 tacgggaatc gatctcattc aggagatgat tcgcgtcgct caaggcgaac ctttatcttt
     4801 ccgtcaagag gatgtcgtca ttgacggatg ggctatagag tgccgtatta atgctgagga
     4861 tccggcacgc aatttcatgc cttcggccgg ccagatcggt ttctatctgc cgccgggcgg
     4921 atttggcgtt cgcgtcgaca gcgccgccta tccaggctgc cagatctcgc cgcattatga
     4981 ttcgatgatt gcgaagctta ttgtgtgggc gccgacgcgc gaagaggcga tcgaccgcat
     5041 gaagcgggcc ttggccgaat tcgccatcga gggcattcat acgacaatac cgtttcatat
     5101 ccgcctgctt gaacaccctg cgttcatcaa gggcgatttt gacattaagt ttttggaaga
     5161 acacgaggtc taatagtcct aggtaagcca gcgccgtttg tcttacgcag ggtcaaatgg
     5221 tatagttagg ttaatcatgg acaggaactg cctctagtac aaaaagatga ggagagtgtg
     5281 acggatgaat caggcaatcg catcggaatt tgagcgcacg gatctgggca acatccagat
     5341 tgcgccggag gttattgcag ttatcgccgg tcttgcgaca atcgaagtgg aaggtgtaga
     5401 aggcatgagc ggcggattcg ccggcggcat cgcagagatg ctcggacgga agaacttgtc
     5461 caagggcgtg aaggtagaag taggacagcg tgaagcggct gtcgatgtca atataattat
     5521 tgagtacggc catcgcattc ctaccgtagc cagcgagatt cagcagaaca tcaagcgctc
     5581 gatcgagatg atgaccgggc ttcatgtggt ggaagtgaac gtgcacgtgc atgatgtcca
     5641 tttcaagtcg caagagaagg ttgaagagac cgatccggga cgagttaaat aagatcgata
     5701 tggaaccccc tcttggaggg ggtttactgc cattcaatac gatattgttc aaaggaggca
     5761 ggctagtgtg agcaaaattg tggacaggct cttcctgttt atatacagtt tcgcgatcgg
     5821 cacgattgcc atagctgtca ttcttgccgc ttcaggcttc atctctcaac ctattcggct
     5881 gacggagccg ttctggctgc agtcgacggt catcgcgacc gctgccgtct tgtttttgtt
     5941 gagcatccgt tttttctatg tgtcgattcg cagagagcgt gcggcgctgc cttcgatcga
     6001 tcagcggaca gagattggcg atatcaaaat ctcgattgag acgatagaga acctggcgct
     6061 caaggcggcc ggacgggtac ggggagtcaa ggacttgaag gcccgcatcc gcacgaatga
     6121 ggccggtctg gacattgtta tccggacggt cgtagacggc gagacatcca ttcctgagct
     6181 gacggaggac gtccagcgcc aagttcgcga ctatgtccag caaattacgg ggattccggt
     6241 ctcatacgta tcagtgtatg tggcgaatgt ggtccagacg cagaccttca aagcgcgagt
     6301 ggaataggtg gtgagctttc cggatgtgga atgaatggtg ggagagtcac aggaatcgca
     6361 tcatcggcat cgcggctgga atttttttcg gcgtcattta tttgatcgcc ggattttggg
     6421 atatgttatt ttttgcgctg ctcgtcttca tcggatacaa tgtaggcagg caacaagatt
     6481 tgaagctggg ccccatgttc ccgtggcggc gtatcggatt atggctgtca gaacggtttg
     6541 ataggtttaa gtagtcctat ggacgctccg aacgactgct tgaccgccgg tctcataccg
     6601 acggaacaac aatcggggcg gtcataggat tttttggact gggcatgatt ccggatgacc
     6661 catggcagcc tagagagaag gagccgcctt ccggcggttg gatgtaagtg gcgattcgga
     6721 tgctatatag atgcaggagg agtttttttc atgaagagac gcattgccag agagatggca
     6781 gttcaaagct tgtatcagct ggaaatgacg gacgtgaccc ctgaacaagc ggtggacatg
     6841 atcgtttcgg aatcgaatca agaagagaat gaaatcgggt tgaagccgga gcacgcgcgg
     6901 gcgatgcatg agcatgtgct ggaatgggtt cgcgatactt ggaagaagcg ggacgagatc
     6961 gatgctcttc tggcccgtta tttgaagggc tggcaggtcg accggctgtc gcgggtcgat
     7021 cgtcaggtgc tgcgccttgc ctgttatgag atggcgttcc gcaccgatgt gccgccgaag
     7081 gtggccatca acgaggcaat cattttggcc aagcatttcg gcaccgagga atcgggcaaa
     7141 ttcgtgaacg gcgtgctcgg ccagatgctg cgcgatcgca gcggcaagca ggacggagct
     7201 gacgcgagcg caggcgcaag cggaagtgct cattccgatg cgatgaggca gcggctggac
     7261 ccgcgttaga cagcgaattg cggggataat ctgcgacatt ggactagctt acatgagcga
     7321 acggaggaga gaccatgaca gcgcaacttt tgaatggcca agcattatca cagacgatcc
     7381 gcgaagaaat caagcagcag gcggcacggc tgatcgagca aggaacccgc cccggattgg
     7441 cggtcatcat cgtgggcgat gacccggctt cccacgtata cgtgaacagc aagcacaaag
     7501 cctgtctcga attgggattc tattcggaag tgcaccgtct ggcggaacag acctcccaag
     7561 aagagcttct ggatctggtc ggccgtctga acgggcaatc gacgattcac ggcatcctcg
     7621 tccagctccc gctgccgtct catatcgatg agaaggcggt cattgacgcg attgcggtgg
     7681 agaaggatgt cgacggtttc cacccggtca gcgtggggaa catggtgctt ggcgacgagt
     7741 ctcttcttcc ttgcacgccg gcgggcatta tggagatgct gaagcgcaac gacattccga
     7801 tcgccggcaa gcatgccgtc gttatcggcc gcagcaatat cgtcggcaag ccgatctcgc
     7861 tgcttctgca gcgggagcat gcgacggtga cgatgtgcca ttcgcgcacg cagcacatcg
     7921 aagagctgtc ccgcatggcc gatattcttg tcgtggccat cggcaaggcg catttcgtga
     7981 accgttcctt cattaagccc ggagccgtcg tcatcgatgt cgggatgaac cggctggaga
     8041 acgggaagct cgttggcgat gtcgacaccg atgacgtgaa ggagctgtgc tcctggatta
     8101 ctccggtgcc gcggggcgtc gggccgatga cgataacgat gctgatgtcc aatacgctca
     8161 agtcggcgga aaggctccac cgcttgggcc aggcttcggt cgaggtgtag ctggcggcaa
     8221 ggcggatacc cgtgcggcgg atcggggcat gaacccgaag acgcttcgaa gcgcgataag
     8281 cagcatgggc cgcggccgct aacgttcgat tggcaggatg tctcggggga ggaggctgcc
     8341 ggaatggcga atcaggcacg ggttctgtcc gttaaggatc tgaaccgtta tatacgaatg
     8401 aagctggatg gggatgcgcg gctgcaggat gtctgggtgc ggggcgaaat ctcgaacttc
     8461 actcaccatt ccagcggtca tatgtatttc acgcttaagg atgcggacag ccgcctgcgg
     8521 accattatgt tcgcatccta caatcaacgg ctccccttcc ggccgaagga aggggcgcgc
     8581 gtcatcgccc gcggcaacgt gacggtgtat gagcgcgacg gccagtatca attctatgcg
     8641 cagcacatgc agccggacgg catcggcagc ctgtatgcgg cgttcgagca gttgaaggag
     8701 cgcttgggag ccgaagggct gttcgccgcc gagcgcaagc ggccgctgcc ccgctatccg
     8761 aagaagattg gggtcattac ttcgcagacg ggcgccgcgg tgcgcgatat tatcattacg
     8821 ctgcggcggc gccaaccggg ggttcatgtg gtcctctatc cggtgctggt gcagggcaac
     8881 caggctgccg tctcgatcgc tgcggccatc gaggccatga accgccacca ggaagccgat
     8941 gtgctgatcg tggggcgcgg cggcggatcg ctggaggaat tgtgggcctt caacgaggaa
     9001 atcgtggccc gcgccatcgc ccaatcggcc atcccggtca tttcggccgt tgggcatgag
     9061 acggacttca cgattgcgga tttcgtcgcc gacctgcgcg cgccgacgcc gacagcagcc
     9121 gccgagttgg cggtgacgca tcaggaggag ttgcggcagc atcttcagca tctggcggag
     9181 cggatgcggc acggcatgcg gcgaacggta cagcagggcc aggaacggct gctgcgcgcc
     9241 cagcgctcgc ctgtgctgcg gaagcccgag ctgttgacgg cgaagcatca ggagcggtat
     9301 gaacggctgc ttgagcggct cgcataccgg tcgcgcagcc gcttcaagca ggcggacgag
     9361 cggtggaggg agctgcgagg acggctgcgg gagcagacgc cggtgcatca ggtccgttcc
     9421 gcccgggagc ggctgaacgg catcgaacgg cagcttcacc gggcgatggc gatgcagatg
     9481 aatgagcgcc gcttgaagct cggcgcgcat ctgaagcatc tggacgcgct gagtccgttg
     9541 aagattatgg cgcgcggcta cagcctcgtc tatgacgagc gggaagagaa cattatccgc
     9601 acgattaggg atgtgcagct gggagacgtc gtccgcgtga agctgaacga cgggcagctc
     9661 gattgccacg tctggtcgat gaaaggagac agcgattgat cgatggataa tcaagaaaaa
     9721 cctaccactc aggaaatgag cttcgagacg gcaatggaga agctggagca tatcgtcgag
     9781 cagttggaga gcggagatgt gccgctggag caggcaatcg agcttttcca ggaagggatg
     9841 ggcctgtccg gtctatgcgc ccgcaagctg gaacaggtgg aacgcaaaat cgaggtcttg
     9901 tcggagcaga atggcgaatt gaagcggcag ccgttcccag tggaagaagc gggtgatcgg
     9961 attgagtagc actggagcgg aagaacggtt cgcttcttat ctggagcgtc acgtcgcgcg
    10021 gattgagcgg ctgctgcccg ctcaattccc tgccggctgg caggtgcctg ccgaattgaa
    10081 ggaatcgatg ttgtattcgc tgatggccgg gggcaagcgc ctgcggccgc tctgtgttgt
    10141 catcgcatgc gagagcctgg atggcccgct ggaagccgcc gatccggttg cctgcgccat
    10201 cgagatgata catacctact ccctcgttca tgatgatctg ccggcgatgg ataacgatga
    10261 ttaccgccga ggcaagccga ccaaccataa ggtgttcggg gaagctctgg ccatattggc
    10321 gggcgatgcg ctcctgaccc atgccttcta tacggttgcg caatgcgcgc gccgtcatgg
    10381 catcccggcc gagatcgccc tgaccatcac cgaggagctg tccttctatg ccggcatgcg
    10441 gggaatggtg ggcggccaga cggccgatat gctgggcgaa cagggaatga cgacgctgga
    10501 ccaggttgag tatattcatc ttcacaagac gagcgatctg atcgtgttcg cgctccgcgc
    10561 gggcgcccat ctggcggggg ccaatgaagc tcagctgaac gcgatgaccg aattcgggac
    10621 gaagctcggc ctcgccttcc agattcagga cgatattctg gatatcaccg gcgaggaagc
    10681 gctgctcggc aagccgaagg gaagcgatga gaagagcgga aaggtgacct acccgtattt
    10741 tatcggtctg gaggcatcga agcaggaggt cgcccggctg acggaggaag cgaagcaagc
    10801 cgtgcggcag gccggatttc cttatccggc gcgcctgtac gagctcgcgg attatttgat
    10861 ggcgcgccga ttctgaatcc ccgccggtct gatgaccggt ggaattccag ggcagcgctt
    10921 ccatggaaat gatatcgcgt gattcgcttt cccgttttgt gatataatag agcgtacata
    10981 gagtggtgca gtattctagt cggcctcccg acaccgaagg cgggcctaaa aattcgccaa
    11041 agggcacatc gatgaagttc ctggtgttgg cttgcgacgc ccagtcgtgg gctgatgctg
    11101 ggagttaagg ttgtggggcg atccacaatg gcatgtgggc gttgaccccg cttccgcgga
    11161 ggcccaagtg cgtggtacgg cgccctcgcg cgccgcatta cggcttgggg tatgaaccta
    11221 taccgcgagt cacgcggaac gctctccggc ttgccggatc gttccgtgat ggtggcttgt
    11281 atgtagcgta gcctgccttg agtgagtctg cagggattgc ggatgtgtag agacgccggt
    11341 cttaggccaa tgaccggcct atcggatgcc gcatgaaatc tgatttgcaa aagaggctaa
    11401 gggtcggttc agggctgctc gaggaaaact cctagactgt tcacattgtg aggctttgtg
    11461 gggattatag tgtggtctaa gtggtaatcc agtctgacgt ccggcgacgg cgtcaagacg
    11521 ctcttaattg gaaacggcct gcccggcgac ggggaggcgg gcgtctggga aaacctactg
    11581 gacctaagcc acagcgttta tccagaaagc taccactcca accatcattg gttatcaaga
    11641 cacatataat ggggtcgttc gtggacctca taaaaggatg agttgacagc gataatgaag
    11701 ttttcattca aacattccgt caagtggagc atattcattt ttttcgtcac ctttgcgctg
    11761 gccgtcatat tgtctgttgc ctccacgtca atgctgggga aagcgggctg gggcgtcggt
    11821 atggtgattg tgttgatgct cgtgcttatt ggagtgtttt ttgatattat gggcttagct
    11881 gcggctgccg cgaaggagac tccgttccat gcgatggcgg cggagaaggt gcgcggagcc
    11941 aagcaagcga tctatatcgt gcgcaacgcg gatcgtttct cgaacttctg caatgacgtg
    12001 attggtgaca tgacaggggt tataagcggt tcggccacgg cgatcgtagt gacgaatttg
    12061 ctatggtcca tgaatgcgga gagcgtatgg atgacgacag cggtaagcgt tgcatttact
    12121 ggccttgtat ccgcattaac cgtcggaggc aaagcgttgg ggaagtcatt tgcgattcat
    12181 tactccactt cgattgtatt gctgatcggc aaatgcttct atttcttgga gaccaagctc
    12241 catattcgct tgctcgccaa gaaacgcggc aaatcgaaac aacgaaagcg agggaattcc
    12301 cgtgctgctc gaacagatta accaacctag cgatctgaag cggttgacga aggaagaact
    12361 gcctgtcctg gcggaagaaa ttcgacaatt tctcattgaa aagctggcgg tgaccggagg
    12421 acatctggca tcgaacctgg gcgtcgtcga gcttacgctt gtcttgcatt atttatatga
    12481 cagtccccgg gacaaaatga tattcgacgt tggccatcag gcatacgtcc ataaaatatt
    12541 gaccggccgc aaggaccggt tcgattcgct gcgccagtat aaagggctgt gcggcttcgt
    12601 caagcgcgcg gagagcgagc atgacgtatg ggaagccggc catagcagca cctcgctgtc
    12661 ggcggcgatg ggaatggcgc tttcccggga tttcaagggc gagagcaaca aggtgatcgc
    12721 ggtcatcggc gacggtgcgc tcactggcgg catggcgctt gaggcgctca atcacatcgg
    12781 gcatgagaag aagaatctga tggtcgtgtt gaacgacaat gagatgtcga ttgccccgaa
    12841 tgtcggagcg ctacataact atttgtgcaa gattcgctcc gaccggaact atttaaaggc
    12901 gaaggaagaa gtcgagcagc tgctcaaaaa gattccggcg attggcggca agctggccaa
    12961 gacggcggaa cgagtgaaag acggctttaa atatttggtc gtgtccggca tgctgttcga
    13021 agagttcgga ctgaaatatt tcggccccgt cgacgggcat gacattgaca agctgatcga
    13081 tatttttcag caagcgagcc gcgtgaacgg cccggtgctt attcatgtcg tgacccgcaa
    13141 aggcaaagga tacacgcccg cggaagccga ttcgcataaa tggcacggca tctcgccgta
    13201 caagattgaa tccgggcaag tgctgaaggc gttaggcaat ccgatgtata ccgaggtgtt
    13261 cggcaagacg ctcgtcgagc tggcggagca ggatgatcga gtggtggccg ttacgcctgc
    13321 catgccgggg ggctccggac tgctcggatt cgctgagcgc ttcccgagcc gcatgatcga
    13381 tgtcggcatc gccgaacagc atgccgccac gatgtgtgcc gcgttggcta tggaagggat
    13441 gaagccggta ttcgcggtat actccacttt cctgcagcgt gcatacgatc aggtggtcca
    13501 tgacatctgc cgccagagcg cgaacgtaat cttcgcaatc gatcgcgccg ggttcgtcgg
    13561 accggacggg gagacgcatc aaggcgtgta cgatatcgct tttatgcgcc atattccgaa
    13621 tatcgtgctg atgatgccga aggacgaaaa tgagctgcgc catatgctga agactgcgct
    13681 cgaatacgat gaaggtccga ttgcggtgcg gtacccccgc gtgaacgggg tcggcgtcga
    13741 actggatgcc gatctgattc cgattccgat cgggacatgg gaaatggttc gccccggcga
    13801 tcatgccgct gtcgtcgcga tcggcccgat ggttcaggtc gccgaggaag cggcggagca
    13861 actgcggcgc gaaggcattc agctgcgcgt catcaatgcg cgcttcatga agccgctcga
    13921 cgaggcgatg ctgactctgc tcgccagaga gcagctgccg atgatcgtgc tggaggaggg
    13981 ctccgtggca ggcggcctgg gcagcgccat catggaatat tatgcgcagc atcatgtatt
    14041 cggcgtcaag gtgaagccga ttggggttcc cgattgcttc gtagagcacg gcagcatcaa
    14101 ggagcagcgc caggaggcag gcctaacggc ggaacagctg gtaaaggaag tccatacgat
    14161 gctcttcgct catggcgata accggatgag ccgggcctag cccgagtaag caatgacaga
    14221 caggagtaca gcatgtccat accgaaggaa cggattgatg ttctgctcgt agagcaggcc
    14281 tattacgaca gtcgtgaaaa agcgaaagcc gccattatgg ccggcttggt atatgtgaac
    14341 gaggaacgga ttgagaaggc ggggacgaaa gtcccgcggg acggaacgat tacggtgaag
    14401 ggcgcggttc atccttatgt aagccggggc ggcttgaagc tggagaaggc gattcgccac
    14461 ttcggcctct ccatgacgga tgccgtcatg ctcgatatcg gcgcttcgac aggaggattc
    14521 accgattgcg cccttcagca tggggcacgt tacgtgtacg ccatcgatgt cggctataac
    14581 cagcttgact ggtcgcttcg caatgacgag cgggtgcatg tcatggagcg gaccaacttc
    14641 cggtatacgg agccggagca tctgcaaggc ccggccccgg atacggcgac catcgatgta
    14701 tccttcatct cgctcaagct gattctgccg ccgcttcagg cgcttatcgg caagccgggg
    14761 cgcgtcatcg cgctaatcaa gcctcaattc gaggcgggaa gagacaaggt cggcaaatcc
    14821 ggcgtcgtcc gcgatccggg gacgcatgag caggtgctga gggagatatt ggattttgcc
    14881 gcatcgttgg gcttccgcct agaaggattg acttattctc ccattacggg aggagaaggc
    14941 aatatcgagt ttttggccta ttggagcgtg ccggacggcg ggtcgccgga acctgcggcc
    15001 tcccgcgagc agattcacgc ggtcgtccag gaggccaatt cggtgttccg ctcgacctct
    15061 taatccttcg tacgattcca tccgcagaag ctcatccggg agagacatcc gacggatgag
    15121 ctttctttat gaattggcag gcaccggcgg tgtctgtcca tcatagcggg gtggtgattc
    15181 cattgagcga tatatgggta atgggattga ttttcatcgg ggtattgatt tggatcggct
    15241 tcggcttgcg gacgtacgcg cattctcccg agccgatgga ggatgtctgc ttgagcgatc
    15301 ggtttcctga ggatgaggag gctctgcagc tggtcgagga tgccggctat gaactcatcg
    15361 gcggcaagtt ctgcacgccc ctgcacttca cgttagacga tgaggagatc gacgcccgca
    15421 tctggatcga catgatcgtc aaacgcgaca atcaatggta tattgttcgt atcgcacgcg
    15481 aacggatgaa gctcgattgg gacggaagcg gcatgaagcg gcaatggatg ccttacttcg
    15541 ccgcctatcc cgagagcgcc ggcctgctcg tggtagatat gttggaacgc agggtgcgcc
    15601 tgattcgcat ggactggggg gaagcctatg tccacggcga ataaggctat actaagtata
    15661 attaacaacc gtcttgctgg ctgcggccaa ggccaagagt agaaggaaca aaaacggagg
    15721 gctcacatga aaggtcaacg acatatcaaa attagggaaa tcattatgaa caacgagatc
    15781 gaaacccagg atgaattagt cgatgcctta cggagcgcag gctaccacgt gacgcaggct
    15841 accgtgtcta gggacatgaa ggagctgcat ttgatcaaag ttccgatgaa agacgggcgg
    15901 tacaaatatt cgctgccggt cgaccagcgc ttcaacccgg cccaaaagct gaagcgggcg
    15961 ctgctggata acttcatcag catcgacagc acggaaaatc tggtcgtgat taaatgtctg
    16021 cctggcacgg caaacgccat tgccgtattg atggatagca tcgagtggcc agagataatg
    16081 ggcaccgtct gcggagacga cacgatactt atcatttgcc ggaccaagca acaaagcgac
    16141 caagtcgtag cgcaaattga agagtatatt tcgtaaacgg catcctggga gggaagtcca
    16201 tgttaatcgc attatccatt acgaatctag cggtcattga atccgttcag cttcagttcc
    16261 atcaaggctt tcacgttctg accggggaga caggcgccgg caaatccatc attatcgatg
    16321 cgcttggatt gatcggggga gcccgcggtt cctcggaatt cgtgcgttat ggctgcgatc
    16381 gggcggaagt ggaggcatcc ttcgatctgc ccgcagacca tccggcatgg gaagctgtcg
    16441 cgaaactggg cattcaggcc gacgcggaag aattgctcat cattcgccgg gaattgacgg
    16501 ccaacggcaa gagcatgtgc cgcatcaatg gccagatggt caatctgacg atgctgcggg
    16561 aagtcggcga gctgctcatc aatattcacg gccagcacga gcatcaatct ctgctcaagg
    16621 tagagcgtca tttggactgg cttgatgcat acggcggcga agatctggct gcgctcaaga
    16681 agcggtaccg ggaagaattc ggctgcttca tggcactgca gcatgagctg aaccaattga
    16741 agcagacgag ccagcaagct tatcagatgc ttgatctgta ccgttttcag attgaggagc
    16801 tccacaatgc caacctccag gtgggcgaag atgaattatt ggcggaagaa aagcgcaaac
    16861 tagcaaatgc cgagaagctg atggatcatg tcaatcatgc ttatgagcga ttgtatggcc
    16921 aaggtgcaat ggatgcggtc agcgtcgcca ttgcgaagct cgaagacgtc atgccgtatg
    16981 atgcggcgcg gttccagcct atggtcgaac agctgcagac cgcttattat caattggagg
    17041 atgcggcgta tcagctgcgc gactaccggg agaacatcga attcaatccg gaacgtctgg
    17101 agcaaatcga ggatcggctg gagcagatga atggattgaa gcggaaatat ggagcgacgg
    17161 tggaagaaat gatcgcctat ggcgaacgga tacaggccga ggcggataaa atcgagcata
    17221 aggatgaacg gattgccgcg ctggagaagg aaagcgagga gaggctggcg aagctggcca
    17281 agagggctca ggcattgagc gatgcccggc gggaattgtc cggtaagctg acgaagcgaa
    17341 tcgagaagca gctgcagcat cttcatatgg aacgaacccg tctcgatgtc cggctggaac
    17401 ggcttcagga tggacaaggc ttcgatgtga acggggtgaa cgttcggttc acgaagaacg
    17461 gatgggacga tgcggaattc ctgatttcac cgaatccggg cgaaccgctg cggccgctgc
    17521 ataagatcgc atccggcggg gagctgtcgc ggattatgtt ggcgttgaag acgatatttg
    17581 ccgagatgga tcgcattccg gtgctggtct tcgatgaggt ggataccgga gtaagcggcc
    17641 gggcagccca ggcgatcgcg gagaagctgg ccgaagtgtc ccgcagcggt caagtgttcg
    17701 cgattaccca tctcccgcaa gtggcgtgca tggccgatca tcattactac atagagaagc
    17761 tcgtgcggga cgagcgcaca tcgacccagg taacggaatt gcaggaacaa ggacgtgtgg
    17821 ccgaactggc tcgcatgctt ggcggcgtgg aagtaacgga aagaaccctg catcatgctc
    17881 aagaaatgct gaagttggct gaacgtcaaa aaggtgcgta attcaagggc ttgaggaatg
    17941 attttcactc ataaaacgct ggggtcaagg ttaccttaat gttacgaaac gggcacgccc
    18001 tttttcgtca aagcttccgt caacaaagga gtgtgacacc tttgaacccc aacgcaaaac
    18061 ggctgctcgg tcttatgctg gccattattg tttgtttatg ctgcaccaca gcccctttcc
    18121 gcacctacgc ggctttgcct aatcatctgc gcctttttga aggagaacac aagcagctga
    18181 atctggttat gcctgtccaa gcgcaggcta ccgtggaccg gcctgatatt ctgaaggtca
    18241 acgggcagag cgagacctcc ttccgcttat cgctgcagaa gccgatctcg ctgcaatctt
    18301 cccagaccgg gcaggctgaa ttgaagctga agctgttcgg cggcattccg ttgaagacgt
    18361 tgaaggtcaa tgtcgttcct aacctgcggg ttgttcccgg ggggcagacg atcggcgtca
    18421 aggtcaaatc ctcggggatt ctcgtcgtcg gacaccatct tgttcatgtc ggacctgacc
    18481 gtaaaatatc gccgggtgaa gaagcgggcg tccggttagg cgacatgatt atgagcatga
    18541 acggaacccg tcttaacgat gtgaccaagg tggcggatat tgttcgggaa gccggcgaga
    18601 agaagcaggc gattgaactg gtcattcaac gaggcgacac cgagatcaag acgaagctga
    18661 agccggctta tgatgtggag gacaagacct ggcggcttgg gttatatatc cgggattccg
    18721 ctgcgggggt aggcacgctt actttttatg ctcctgatca aggagtgtac ggcgcgcttg
    18781 gccatgtcat taccgacatg gatacccaga cgcccatcac ggtaggccag ggtgagattg
    18841 ttcagtccaa cgtgacctcc atctccaaaa gtcaaaatgg cgagcctggc gagaagcggg
    18901 ctcatttctt gaaggaaagc cgcgtgttgg gcaatattga acgcaataca ccgtttggca
    18961 tttttggaaa aatgacgaat caaccggagc acagtttgta caaggagccc atccctgtcg
    19021 cttttagcga ggaagtgcag gaaggccccg ccgaaatgct tacggtcgtc aacggccagc
    19081 aggtggaacg attcaagctg gaagtggtcc atgtgacgaa gcagacgtca ccggccacca
    19141 aagggatggt catccgcatt acagacccta gattgctgca aaagaccggg ggcattgtcc
    19201 aagggatgag cggaagtccc atcatacaga atggcaaact cattggcgcc gttactcacg
    19261 tgttcgtcaa tgatccgagc tccggctacg gatgcttcat tgaatggatg ctgcaggatg
    19321 cgggcgtggt gctctcgcca cccccgacct ccagcagaga aggctcacat gctgcgtgag
    19381 ccttcttttt ttgcgctaat tcgccttttg catgtcgaag gaatgtgaat gatgtagaaa
    19441 aaatgaataa ctatacatta taaatcatgt tcttaaaaaa ataaagaaaa aaagttttcg
    19501 acagaaggaa tttcattctt ggtgtcgaat aagttattct tgtagaggaa agccaacgac
    19561 atcaatgtac gggaatgcta aactttgaca agggaggatc agaagttgca aaagatcgaa
    19621 atactgttag cggacgacaa ccgagaattc acgaatttat tagctgattt tttatcagaa
    19681 caggaagaca tggttgtcac tggtgtcgcc tataatggcg aggaggtgct tcaattcctg
    19741 gaacagacga gagcggtgcc agatgtgctc attctcgata ttattatgcc tcacctggac
    19801 ggtctgggcg tgttagaacg tttacgcagt atgaatctgt ctccgcaacc aaagatcatc
    19861 atgctgaccg cattcgggca ggagagcatt acacagcgtg ccgtgcagct gggcgcgtcc
    19921 tattatatcc tgaagccgtt cgacatggat atcctggcga accgtatccg tcagctggct
    19981 ggggtcgctt cgacaccgtc tataggcagc tccaatgccg gcagctacat gacctcctcg
    20041 aagtcgaatg tcgtccaatt gggcaagacc aagaatttgg atgcaaatat tacgtccatc
    20101 atacatgaaa tcggcgttcc ggcgcatatt aaaggatatc agtacttgcg cgaagcgatt
    20161 acgatggtgt acaacaacat cgaaattctc ggctcgatca cgaaaacgct ctatccggcc
    20221 attgccgaga aatacaaaac aacgccttcc cgcgtcgagc gcgcgattcg ccatgccatc
    20281 gaggtggcct ggacccgcgg caacatcgac agcatcagcc gcctgttcgg ctacaccatc
    20341 aacatcagca agtcgaagcc aaccaacagc gagttcatcg cgatggtcgc tgataagctg
    20401 cggattgagc ataaggtgag ctgaagggag taggggtgtg gggttgcggg attatttcgc
    20461 tatttataaa ataccgataa actcgctttt gtgattacct ttttttccat tcacacgagg
    20521 gacccggaat tctagggtcc agcctactcc tttttggacg caagagccgc gggatgattc
    20581 ctgcggctct gttagcgcgt ggcaagaaag ccaactttaa ttgttcttct attttcgatt
    20641 ctagcccaca acctcaaaat aagatgtatc aaaagcacga atctctacta tagcttgttc
    20701 atgttgaagt tcttcctttt cttgagtcgt tgacaggtgc tctgaattcc attcggcaac
    20761 ttctcctttt attgctataa aatacaccgg aaagaaattg gtcaaccatt tttgcttcat
    20821 taaataagct tcagtactat caatcctaaa attttattca tttttcacct caccac
//
