LOCUS       NZ_CP116962            22982 bp    DNA     circular CON 10-MAR-2024
DEFINITION  Enterococcus faecalis strain DM86 chromosome, complete genome.
ACCESSION   NZ_CP116962
VERSION     NZ_CP116962.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 2959291)
  AUTHORS   Shen,W. and Cai,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JAN-2023) Clinical Microbiology Laboratory, The Second
            Affiliated Hospital of Zhejiang University School of Medicine,
            Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v.0.4.4
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore
            PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/10/2024 16:14:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,086
            CDSs (total)                      :: 3,005
            Genes (coding)                    :: 2,954
            CDSs (with protein)               :: 2,954
            Genes (RNA)                       :: 81
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 18 of 51
            Pseudo Genes (incomplete)         :: 29 of 51
            Pseudo Genes (internal stop)      :: 12 of 51
            Pseudo Genes (multiple problems)  :: 6 of 51
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:47:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2700574
            Orig. end                         :: 2723556
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116962.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22982
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="6"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22982
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22982
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12982](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12982)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    37..50
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.65"
                     /tool="antismash"
     misc_feature    286..306
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.3"
                     /tool="antismash"
     misc_feature    584..598
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 16.36"
                     /tool="antismash"
     gene            complement(1237..1773)
                     /locus_tag="PO880_RS12975"
                     /old_locus_tag="PO880_12975"
     CDS             complement(1237..1773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016634928.1"
                     /locus_tag="PO880_RS12975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_12975"
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="WP_002358518.1"
                     /transl_table=11
                     /translation="MEKTKVSVKEETKKENVQGKLTYEDKVIQKIIGISLEKVEGLLTV
                     DGGFFSNLAGKLVNTDDVTSGVVVEVGEKQVAVDLDIVAEYGKDIYKIYNEMKEIITKE
                     VKNMTGLEVIEVNVNVVDIKTEEQHEEDSVSLQDKVGEATESVSNFASEQTEKAKELAS
                     KGSSKAKELTESRVK"
     gene            complement(1802..1993)
                     /locus_tag="PO880_RS12980"
                     /old_locus_tag="PO880_12980"
     CDS             complement(1802..1993)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358517.1"
                     /locus_tag="PO880_RS12980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_12980"
                     /product="DUF2273 domain-containing protein"
                     /protein_id="WP_002358517.1"
                     /transl_table=11
                     /translation="MKELFLEYKYPIIGGLIGLVLALFFFTIGFFKTILLLVMVGIGVF
                     IGSYIKNEDLFGKFFQNK"
     gene            complement(2010..2576)
                     /gene="amaP"
                     /locus_tag="PO880_RS12985"
                     /old_locus_tag="PO880_12985"
     CDS             complement(2010..2576)
                     /codon_start=1
                     /gene="amaP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002417140.1"
                     /locus_tag="PO880_RS12985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_12985"
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="WP_010706722.1"
                     /transl_table=11
                     /translation="MTKGKKILFSFISLVFGTFLFAVFVHYQFMYSLPIYFIKFEEYPF
                     IGNYIQLYLYWGSVIGMVFILLFILGIVLSPAEVTSVKLNDDKGILEIKKSAIVGIVQS
                     QLDQSNLLRDSKVNVKMYKKKIKVRITGNTSDNLDIINQTNQLVKNIELYLKTFIGLDT
                     SIKAEVVFKNISRSGKSKQKQKRVI"
     gene            complement(2846..3133)
                     /locus_tag="PO880_RS12990"
                     /old_locus_tag="PO880_12990"
     CDS             complement(2846..3133)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.4"
                     /locus_tag="PO880_RS12990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_12990"
                     /product="S41 family peptidase"
                     /protein_id="WP_306418522.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 1.5e-10, bitscore:
                     38.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGTINELNLYKLSLHKKKLGKKVAVVINNNTASAAESLLLALKN
                     NPNVKVFGMPSAGYTSVNLGRFFTNQNSDNYWWFVYTVGYYETIKPIKGK"
     gene            complement(3147..3728)
                     /locus_tag="PO880_RS12995"
                     /old_locus_tag="PO880_12995"
     CDS             complement(3147..3728)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401490.1"
                     /locus_tag="PO880_RS12995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_12995"
                     /product="hypothetical protein"
                     /protein_id="WP_002401490.1"
                     /transl_table=11
                     /translation="MSIKKYLLFYIISTCAIIFVSLTFFFLPLKSIDSRSYEVLHTISQ
                     YGVISNKDEWRNILELTRYGRKVTNVDNLNTLVYGVNKHSSVKQISSDKDMDNMETLKL
                     PSISKYEDLTIINIPSVYSNDDNFSIKYASKLTDLIEYTSGNIVLNLSNNYGGLKEPMI
                     IGASSLIPNGMLFSNINNKKEKYPVYLKKW"
     gene            complement(3806..4273)
                     /locus_tag="PO880_RS13000"
                     /old_locus_tag="PO880_13000"
     CDS             complement(3806..4273)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358512.1"
                     /locus_tag="PO880_RS13000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13000"
                     /product="hypothetical protein"
                     /protein_id="WP_002370921.1"
                     /transl_table=11
                     /translation="MDITDKENFQKQMDFLKRHNFYQYVYQFRWLFVFIPVLVFFDLIF
                     IDFFWLIIVKGILLMGILISEYYVMYRFFKPIALDEKQDFSSVQLFLNLFIFNALFMFV
                     MLTNFHQVFVGKEFIIFGSFMGGIFTICLKEQLKEYQKLMNQFIDIKKEVH"
     gene            complement(4710..5273)
                     /locus_tag="PO880_RS13005"
                     /old_locus_tag="PO880_13005"
     CDS             complement(4710..5273)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358511.1"
                     /locus_tag="PO880_RS13005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13005"
                     /product="hypothetical protein"
                     /protein_id="WP_002370925.1"
                     /transl_table=11
                     /translation="MNNEEQQTKQECRTLKKGAEHIKRQRMFESRSNEIKEGLIDEDTF
                     ARHRLTYSNNHLKENLLKSCKKNIDTHIQNLKIYKGNKAHGIFLIEYNEEIALSMAEVI
                     SVSDVNHGEPQIFDHYVFSKDKDMLQLLNDYNEEIEFFIVSTKFNGTEVIKVRDIPNII
                     DSLPYEYIVASNYGEVETEAWVKE"
     gene            complement(5626..6609)
                     /locus_tag="PO880_RS13010"
                     /old_locus_tag="PO880_13010"
     CDS             complement(5626..6609)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358185.1"
                     /locus_tag="PO880_RS13010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13010"
                     /product="site-2 protease family protein"
                     /protein_id="WP_002368282.1"
                     /transl_table=11
                     /translation="MKFISPMIFTLLLVIFTLVFELNLVSTAYFSLLLSIFVHELGHLV
                     FGLFNKVRPESLIFGFIKLSWEKQFKVRLNTQWGFFGGLFRYKPTTFNNKKILRLLTGG
                     PIFSLFFTLTFFVKIEFFQYFSLFNFSIFLITAVPFNFNGFMNDGYNIYKLVTKDYIFE
                     MYYIVSNSLLNKYNQSTFLNSNEVCKIIKKNKELPLYVLNTFLLYVIYEYLIDKNNRKL
                     KLIYPILSKEDKILNNKSYLQNFYLANLYMIEYILSVDNKQTFKKINLKILDSISRSRI
                     KYLNFKCSKSADDEISQSMTEFSNIIKNYSDQTSTMIIAEKQWVQN"
     gene            complement(6610..7848)
                     /locus_tag="PO880_RS13015"
                     /old_locus_tag="PO880_13015"
     CDS             complement(6610..7848)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358184.1"
                     /locus_tag="PO880_RS13015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13015"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_002368283.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 8.9e-36, bitscore:
                     121.0, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRGLTYILISYIFLTLGTTGYASDLSNNISFFIDNSQTTAIEE
                     IESELSSEKVDYIQEIGLVSFKNLDDSDRKFIGKYFNVSEGKKLPDFKPEEVNSSILNI
                     NILNKDFKSFNWPYKKILSHIDPVKEQLGKDITIALIDSGIDRLHPNLQDNNLRLKNYV
                     NDIELDEYGHGTQVAGVIDTIAPRVNLNSYKVMDGTDGNSINMLKAIVDATNDQVDIIN
                     VSLGSYKNMEIDDERFTVEAFRKAVNYARKNNILIVASAGNESRDISTGNEKHIPGGLE
                     SVITVGATKKSGDIADYSNYGSNVSIYGPAGGYGDNYKITGQIDAREMMMTYYPTSLVS
                     PLGKAADFPDGYTLSFGTSLATPEVSAALAAIMSKNVDNSKDSNEVLNTLFENADSFID
                     KNSMLKYKEVRIK"
     gene            complement(7845..9989)
                     /locus_tag="PO880_RS13020"
                     /old_locus_tag="PO880_13020"
     CDS             complement(7845..9989)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002415198.1"
                     /locus_tag="PO880_RS13020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13020"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_002370927.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.8e-42, bitscore:
                     139.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLKYVAQGEHSECALACITMLLNYYGNQSTLVELREKYGVPKG
                     GLTIKNIRTVFDEYGFDVSTFKSSFSNYLDLPTPVISYWNNQHFVVIEKIKKKKVLILD
                     PASNKRWIDISEFKKNFSNILIYAHKKKTKKEGKRKQFFLKSFIFTKFKRYFFSLIILS
                     FVSQLLLLLIPIATKYSIDNIRSFQEIPTYVLLLILTSFFSVLYVVQYLKSSVVAEFQY
                     EFDFKLMFSYIDKLFSMPLMYFSNRSTGELVFRANLNIYIRQILSQKVITTLIDSLFLG
                     IYLFLMVNYSILLTIIALVLISLIAFLSIINSHTIKRFVDKEIMEQGNVQRIITEAIEG
                     IETIKSANAEKSFLLNWKNMFTSQLLITKNKNRYIAIFGILPEIIQSVMPALFLIIGIK
                     LIINNSLSLGSLIGFVSIVTMVMKPILSLVSSYNDFLLLNVYFQKLSEVLTYEEKNDFN
                     NKKGNVGKEEFIYRVNNVYYTISVFEKNILNGISFDIRKGDKVAIVGRSGSGKSTLLKL
                     LAGLLQPSNGEILYEGYPLSNNSNNRRNIFYVNQNAHIFNETIEKNISLEFKPNSSINE
                     KKRLKESMSKSKMDEVLLGIPQYEKTIVSENGSNFSGGQRQKIALARAFYSNVNTLLLD
                     EPTSAMDNISEFEVFSNLLDEKRTVITVAHRISTVRNFDKIILMDNGEIVCIGKHEDLI
                     ENSELYRSLYYKKQQFGGTK"
     gene            complement(10001..12982)
                     /locus_tag="PO880_RS13025"
                     /old_locus_tag="PO880_13025"
     CDS             complement(10001..12982)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002368286.1"
                     /locus_tag="PO880_RS13025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13025"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_002370929.1"
                     /sec_met_domain="DUF4135 (E-value: 3.2e-93, bitscore:
                     310.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-50, bitscore:
                     168.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDNLINVLSINERCFLLKQSGKEKYDIKNLQAWKERKSVLKQDD
                     LDYLIKYKYESLDNFGLGITPIENFPDKEVAIQYIKDQSWYIFFESILDSYNDSEEKLL
                     EVDASYPFRYFLQYARLFLLDLNSELNICTKEFIINLLETLTQELIHLTSKTLVLDLHT
                     FKKNEPLKGNDSSKRFIYYLKKRFNSKKDIIAFYTCYPELMRITVVRMRYFLDNTKQML
                     IRVTEDLPSIQNCFNIQSSELNSISESQGDSHSRGKTVSTLTFSDGKKIVYKPKINSEN
                     KLRDFFEFLNKELEADIYIVKKVTRNTYFYEEYIDNIEINNIEEVKKYYERYGKLIGIA
                     FLFNVTDLHYENIIAHGEYPVIIDNETFFQQNIPIEFGNSATVDAKYKYLDSIMVTGLV
                     PYLAMKDKSDSKDEGVNLSALNFKEQSVPFKILKIKNTFTDEMRFEYQTHIMDTAKNTP
                     IMNNEKISFISYEKYIVTGMKSILMKAKDSKKKILAYINNNLQNLIVRNVIRPTQRYAD
                     MLEFSYHPNCFSNAIEREKVLHNMWAYPYKNKKVVHYEFSDLIDGDIPIFYNNISKTSL
                     IASDGCLVEDFYQESALNRCLNKINDLCDEDISIQTVWLEIALNIYNPYKYINDLKNQN
                     SNKYIYTGLELNGKIIQACQKIEKKIFKRAIFNKKTNTVNWIDIKLDQDWNVGILNNNM
                     YDGLPGIFIFYVALKYITKNHKYDYVIECIKNSIYTIPSEDILSAFFGKGSLIYPLLVD
                     YRLNNDINSLNVAVEIADMLIEKKPINNGELKNDWIHGHNSIIKVLLLLSEITEDEKYR
                     KFSLEIFEKLSEEPYFNFRGFGHGIYSYVHLLSKFNRIDKANSLLHKIKESYFEEEPKN
                     NSWCKGTVGELLATIELYDDNISNIDINKTIAYKNKDCLCHGNAGTLEGLIQLAKKDPE
                     TYQYKKNKLISYMLNDFEKNNTLKVAGSEYLESLGFFVGISGVGYELLRNLDSEIPNAL
                     LFEL"
     gene            complement(13043..13234)
                     /gene="cylL-S"
                     /locus_tag="PO880_RS13030"
                     /old_locus_tag="PO880_13030"
     CDS             complement(13043..13234)
                     /codon_start=1
                     /gene="cylL-S"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358181.1"
                     /locus_tag="PO880_RS13030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13030"
                     /product="lanthipeptide cytolysin subunit CylL-S"
                     /protein_id="WP_002358181.1"
                     /transl_table=11
                     /translation="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGSGDVQAETTP
                     ACFTIGLGVGALFSAKFC"
     CDS_motif       complement(13127..13234)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /locus_tag="PO880_RS13030_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13043..13126)
                     /prepeptide="core"
                     /locus_tag="PO880_RS13030_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="2632.0"
                     /monoisotopic_mass="2630.3"
                     /core_sequence="GDVQAETTPACFTIGLGVGALFSAKFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /leader_location="[13126:13234](-)"
                     /alternative_weights="2650.0"
                     /alternative_weights="2668.0"
     gene            complement(13268..13474)
                     /gene="cylL-L"
                     /locus_tag="PO880_RS13035"
                     /old_locus_tag="PO880_13035"
     CDS             complement(13268..13474)
                     /codon_start=1
                     /gene="cylL-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358485.1"
                     /locus_tag="PO880_RS13035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13035"
                     /product="lanthipeptide cytolysin subunit CylL-L"
                     /protein_id="WP_002358485.1"
                     /transl_table=11
                     /translation="MENLSVVPSFEELSVEEMEAIQGSGDVQAETTPVCAVAATAAASS
                     AACGWVGGGIFTGVTVVVSLKHC"
     CDS_motif       complement(13403..13474)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENLSVVPSFEELSVEEMEAIQGS"
                     /locus_tag="PO880_RS13035_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13268..13402)
                     /prepeptide="core"
                     /locus_tag="PO880_RS13035_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="4019.5"
                     /monoisotopic_mass="4017.0"
                     /core_sequence="GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKH
                     C"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENLSVVPSFEELSVEEMEAIQGS"
                     /leader_location="[13402:13474](-)"
                     /alternative_weights="4037.6"
                     /alternative_weights="4055.6"
                     /alternative_weights="4073.6"
                     /alternative_weights="4091.6"
                     /alternative_weights="4109.6"
     misc_feature    13877..13892
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.29"
                     /tool="antismash"
     gene            13878..14078
                     /gene="cylR2"
                     /locus_tag="PO880_RS13040"
                     /old_locus_tag="PO880_13040"
     CDS             13878..14078
                     /codon_start=1
                     /gene="cylR2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) triceptide_precursor"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002370931.1"
                     /locus_tag="PO880_RS13040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13040"
                     /product="cytolysin regulator CylR2"
                     /protein_id="WP_002370931.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIINNLKLIREKKKISQSELAALLEVSRQTINGIEKNKYNPSLQL
                     ALKIAYYLDTPLEDIFQWQPE"
     gene            complement(14416..14730)
                     /locus_tag="PO880_RS13045"
                     /old_locus_tag="PO880_13045"
     CDS             complement(14416..14730)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002360727.1"
                     /locus_tag="PO880_RS13045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13045"
                     /product="hypothetical protein"
                     /protein_id="WP_002403043.1"
                     /transl_table=11
                     /translation="MILAGDLKDLVNRDTVTVHSTSLFKDSPVFVNSSKNYPILKELVP
                     PNEALYWPNQFLFRTYTGLNVNMEIFDINALNKEESDLMKSNYYHDIYVKDSEVFVHVK
                     "
     misc_feature    complement(14681..14693)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(14903..15547)
                     /locus_tag="PO880_RS13050"
                     /old_locus_tag="PO880_13050"
     CDS             complement(14903..15547)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /locus_tag="PO880_RS13050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13050"
                     /product="IS6 family transposase"
                     /protein_id="WP_272731503.1"
                     /transl_table=11
                     /translation="MIIVAVGYYLRYNLSYREVQEILYDRGINVSHMTIYRWVQEYGKL
                     LYQIWKKKNKQSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWLRKKRDTQAAYAF
                     LKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLNNLIEQDHRPVKR
                     RNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLLGIPA"
     gene            15680..16562
                     /locus_tag="PO880_RS13055"
                     /old_locus_tag="PO880_13055"
                     /pseudo=""
     CDS             15680..16562
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013068.4"
                     /locus_tag="PO880_RS13055"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13055"
                     /product="IS256 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPRDRNGEFKQQTVPAYRRTNDTLEETVIHLFRKGITMSEIAD"
     CDS             complement(16587..16652)
                     /gene="allorf_2717161_2717226"
                     /locus_tag="allorf_2717161_2717226"
                     /protein_id="allorf_2717161_2717226"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVTMLLQFLLYQPGASIILCK"
     CDS_motif       complement(16608..16652)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVTMLLQFLLYQPGA"
                     /locus_tag="allorf_2717161_2717226_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16587..16607)
                     /prepeptide="core"
                     /locus_tag="allorf_2717161_2717226_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.30"
                     /molecular_weight="657.9"
                     /monoisotopic_mass="657.4"
                     /core_sequence="SIILCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVTMLLQFLLYQPGA"
                     /leader_location="[16607:16652](-)"
     gene            complement(16867..17904)
                     /locus_tag="PO880_RS13060"
                     /old_locus_tag="PO880_13060"
     CDS             complement(16867..17904)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007208410.1"
                     /locus_tag="PO880_RS13060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13060"
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="WP_002355369.1"
                     /transl_table=11
                     /translation="MEEKLTPKIFLNKVLAGTATGIIVGLIPNAVLAAILKLFGENTLA
                     VTITQMAVIFQLATPLLIGALIAVQFGFKPMQMLVVAGAAFVGSGVVKFNPDTATYIGA
                     GTGDIINTMITASIAVGMILLIGEKFGSVAIVATPIVVGIGAGLIGYYLYPYVTKITAA
                     IGDLINTFTTLQPILMSILIACSFAFLIISPISTVAIGMAIQLNGVSAGAAAMGVAATT
                     VVLVVNSWKVNKPGVTLAIALGAMKMMMPNLFRKPIILVPCLFTAIISAIPVALFSVSG
                     TPASAGFGLVGLVGPLASLDAGLSIILLLISWFVVPIVAAFVGQILFEKILKLYDRKDV
                     FEFLG"
     gene            complement(17930..18868)
                     /locus_tag="PO880_RS13065"
                     /old_locus_tag="PO880_13065"
     CDS             complement(17930..18868)
                     /EC_number="1.1.1.169"
                     /GO_function="GO:0008677 - 2-dehydropantoate 2-reductase
                     activity [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015081805.1"
                     /locus_tag="PO880_RS13065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13065"
                     /product="2-dehydropantoate 2-reductase"
                     /protein_id="WP_002370935.1"
                     /transl_table=11
                     /translation="MKIAIAGAGAMGSRFGLMLKQGGNDVLLIDGWQEHINAIKENGLK
                     ANYNGEEITVKVSIVNQNEVPTGEQFDLIILFTKAMQLEKMLQDVKPLIADHTEVLCLL
                     NGIGHEDVIEKFVPMEKIFIGNTMWTAGLEGPGKAKLFGSGSVELQNLGIGQEESAKKL
                     AETLSASGLNAKYSDNIHYSIYRKACVNGTMNGLCTILDVNMAGLGATKPAHDMVVTIV
                     NEFAAVAAKENVNLDIPEVIEHVETCFDPTTIGMHFPSMHQDLIKNNRLTEIDYINGAI
                     SRKGKKYGVVTPYCDFLTQLVHSKEEILGAK"
     misc_feature    complement(18900..18915)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            complement(18996..>19265)
                     /locus_tag="PO880_RS13070"
                     /old_locus_tag="PO880_13070"
                     /pseudo=""
     CDS             complement(18996..>19265)
                     /GO_component="GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002409912.1"
                     /locus_tag="PO880_RS13070"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13070"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ENPVNTDTGVVIVAVEDSKPIIQLADGTTKKVEAKEIGADVQKDG
                     TVTVKGSDGRMKVLPKTGETENIALSVLGSLMVLGSAFIFKKRI"
     gene            19355..19540
                     /locus_tag="PO880_RS13075"
                     /old_locus_tag="PO880_13075"
     CDS             19355..19540
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358660.1"
                     /locus_tag="PO880_RS13075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13075"
                     /product="hypothetical protein"
                     /protein_id="WP_002358660.1"
                     /transl_table=11
                     /translation="MKEDKIHVLSLFISSIVLFLITIIFHEIAIGLVIALICFPISNSI
                     AKKGSVAKFSKKSILV"
     CDS_motif       19355..19447
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKEDKIHVLSLFISSIVLFLITIIFHEIAIG"
                     /locus_tag="PO880_RS13075_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       19448..19540
                     /prepeptide="core"
                     /locus_tag="PO880_RS13075_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="3085.8"
                     /monoisotopic_mass="3083.9"
                     /core_sequence="LVIALICFPISNSIAKKGSVAKFSKKSILV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKEDKIHVLSLFISSIVLFLITIIFHEIAIG"
                     /leader_location="[19354:19447](+)"
                     /alternative_weights="3103.8"
                     /alternative_weights="3121.9"
                     /alternative_weights="3139.9"
                     /alternative_weights="3157.9"
     gene            19572..>20180
                     /locus_tag="PO880_RS13080"
                     /old_locus_tag="PO880_13080"
                     /pseudo=""
     CDS             19572..>20180
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010868911.1"
                     /locus_tag="PO880_RS13080"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13080"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNHFKGKQFKKDVIIVAVGYYLRYNLSYREVQELLYDRGINVCHT
                     TIYRWVQEYSKVLYDLWKKKNRQSFYSWKMDETYIKIKGRWHYLYRAIDADGLTLDIWL
                     RKKRDTQAIVTDKAPSLGSAFRKLQSVGLYTKTEHRTVKYLNNLIEQDHRPIKRRNKFY
                     QSLRTASSTIKGMETIRGIYKKNRRNGTLFGFSVSTEIKV"
     gene            complement(20849..21823)
                     /gene="bsh"
                     /locus_tag="PO880_RS13085"
                     /old_locus_tag="PO880_13085"
     CDS             complement(20849..21823)
                     /EC_number="3.5.1.24"
                     /codon_start=1
                     /gene="bsh"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002342103.1"
                     /locus_tag="PO880_RS13085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13085"
                     /product="choloylglycine hydrolase"
                     /protein_id="WP_002355428.1"
                     /transl_table=11
                     /translation="MCTAITYVSKDHYFGRNFDYEISYNEVVTITPRNYKFSFREVGNL
                     DHHFAIIGIAAGIADYPLYYDAINEKGLGMAGLNFSGYADYKKIEEGKENVSPFEFIPW
                     VLGQCSTVDEAKKLLKNLNLVNINFSDELPLSPLHWLLADKEQSIVVESTKEGLRVFDN
                     PVGVLTNNPTFDYQLFNLNNYRVLSTRTPKNNFSDQIELDIYSRGMGGIGLPGDLSSVS
                     RFVKATFTKLNSVSRSSEYESISQFFHILSSVEQQKGLCDVGDEKYEYTIYSSCCNLEK
                     GIYYYRTYDNSQITAVDMNKENLEKDSLIVYPMVETQQINYAN"
     gene            22047..22691
                     /locus_tag="PO880_RS13090"
                     /old_locus_tag="PO880_13090"
     CDS             22047..22691
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /locus_tag="PO880_RS13090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_13090"
                     /product="IS6 family transposase"
                     /protein_id="WP_002377952.1"
                     /transl_table=11
                     /translation="MIIVAVGYYLRYNLSYREVQEILYDRGINVSHTTIYRWVQEYGKL
                     LYQIWKKKNKQSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWLRKKRDTQAAYAF
                     LKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLNNLIEQDHRPVKR
                     RNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLLGIPA"
ORIGIN
        1 actaaacgtt catcgatttt gtagttagca taccaaggcg ttccctttgc agaagttgaa
       61 taagaaaaat tcttttcttt cgttaactta tgatctaaaa ttatagctcc attagcacca
      121 gtagacccag aaccgtcttt tgtttggata ttagcttctt catatttagt atttaccgat
      181 ccatgcttaa attgatcaga attattttcg gatacatcta acttattata gaaatcatct
      241 tgatctgtca aaaagtaacc agtgctttct attccaggta caattttatc gtcatcttga
      301 tgacttacca aatagatacg atacattaaa cggtcgcttt taagattatc tgcaccaatt
      361 tctttaaaaa tttcatctaa atttttttca aatgtaatca caccgttagg agcagtttgt
      421 gtatcagttg tttctgcccc agcaaatagt ccatcatttg ctcgaatgta attaaccttc
      481 caaatgtttg taggtctgcc aagcgaatca ttaattctta caaaagttcg tctactattt
      541 cctacgccct tcttcggatc aacttgaatt ttttcaacat actgggccaa tcgttcatct
      601 aattgaagac gaatttccca gtttgcagtt gaagctgcaa tattatgttt cccataaacc
      661 tcaaaatcaa ttgtatttcc ttgtaacaca tcaccagtta ttgctttagg gttgaattgt
      721 aaatccgaga aattataatt cttcgtatat cccggatttt cttgaaacgt atttcctgaa
      781 gcagaataat ttactaatct tccttcaccc atttgtgcat taactattcc agttgcccca
      841 aaaacaaggc ctacaccaac taatactgat gcaacaccca cacttaattt ttttatgcta
      901 tactttaata ctctttttct cccttttttt aaaatcatat gcttattgtt ttttccaaac
      961 aaactaaatt tgctcccttc cttatttaaa tttaaaatta catttttatt ataaataata
     1021 caaaatagga attcttgtaa atatcacaaa tatttgtaaa aaaatcaaaa aaataaaata
     1081 ttataaaaaa aaccgacctt tacggggtca ctggaacatc cctagaaatc aagtaaaaaa
     1141 aatccagagg attttctcct ctggattcac tattactcta cattttttag ttattttatt
     1201 attcaattat tctcattaaa aatttttctt tctatattac ttaacacgag attccgttaa
     1261 ttcttttgct ttagaacttc ctttagaagc tagctctttt gctttctctg tttgctcact
     1321 ggcaaaatta cttactgatt ctgttgcctc accaacctta tcttgtaaac taacggaatc
     1381 ttcttcatgc tgttcttctg tcttaatatc aacaacattt acatttactt caataacttc
     1441 taacccagtc atatttttta cttcttttgt aataatttct ttcatttcat tgtaaatttt
     1501 ataaatatct tttccatatt ctgcaacaat atctaaatct actgctacct gtttttctcc
     1561 tacttcaacc actacacctg atgtaacatc atcggtattc actaacttac cagctaaatt
     1621 tgagaaaaat ccaccatcaa ccgtaagcaa tccttctact ttttctaaag aaatgccaat
     1681 aattttttga atcactttat cttcatacgt taattttcct tgtacatttt ccttctttgt
     1741 ttcttccttt acacttactt ttgttttctc catttgtatc cactcctaaa tattctttat
     1801 tttatttatt ttggaaaaat tttccaaata aatcctcatt tttaatataa ctccctataa
     1861 atacaccaat cccaaccata actaataaga gaattgtttt aaaaaaacca atagtgaaaa
     1921 agaaaagtgc taataccaat cctattagtc ctccaataat tggatactta tattctagga
     1981 acaattcttt catattctcc cctctttctt taaatcactc gtttttgttt ttgcttactc
     2041 tttcctgaac gagatatatt tttgaaaact acttctgctt ttattgaagt atctaatcct
     2101 ataaaagttt taagatataa ctcaatattt tttactaatt gattcgtttg atttataata
     2161 tctagattgt cacttgtatt tcctgtaata cgtactttta tctttttctt atacattttt
     2221 acatttactt ttgaatccct taataaattg gactgatcta attgcgactg aacaattcct
     2281 acaatagcac tttttttgat ttctaatatt cctttgtcat cgtttaattt cacggatgtt
     2341 acttctgctg gacttaaaac aatccctaaa ataaataaaa ggataaagac catacctata
     2401 acactacccc agtacaaata tagttgaatg taattcccta taaaaggata ctcttcaaac
     2461 ttaataaaat aaataggtaa tgaatacatg aactgataat gaacaaatac tgcaaataaa
     2521 aaagttccaa aaactaaaga aataaaacta aacaaaattt ttttcccttt cgtcatcgat
     2581 tctcccccca ctttcatgtg acttttacca caatataatt ttagcaaaag cctttctcct
     2641 ataaaaattt tatgcttaca agttatacta tacattaaga attcatttac tttaatgtac
     2701 cttcaactca atcagagtta atccaatttt ttatttcttt gaatagtttc ttggtattag
     2761 aaaattgtgt aatatcttga gtatttctat ctaacatcga taaatctaca taataatctg
     2821 gcgggacagg ttgattgtta aacaatcatt ttccctttat gggctttatt gtctcataat
     2881 agccaacagt atatacaaac caccaataat tatcggaatt ttgattagta aaaaaacgtc
     2941 ctaaattaac cgaagtatat cctgcagaag gcataccaaa aacttttaca tttggattat
     3001 tctttaacgc taaaagtaaa ctctcagcgg cacttgctgt gttattattt attacaactg
     3061 caactttttt ccctagtttc tttttgtgta atgataattt ataaagattc agttcgttaa
     3121 tcgttcctgg aatgccacca aataatttac cattttttta agtaaacagg atacttttcc
     3181 tttttattat taatattgct aaagagcatt ccattaggaa ttaaagaact cgcaccaata
     3241 atcataggtt ctttcagccc gccataatta tttgataaat ttaaaacaat gttaccagaa
     3301 gtatattcga ttaaatctgt caactttgat gcatatttaa ttgagaagtt atcatcattg
     3361 ctatagacac ttggaatgtt aataattgta agatcctcat actttgaaat acttggtaac
     3421 ttaagagttt ccatattatc catatctttg tcactactta tttgttttac agaactatgt
     3481 ttgttaacac catatactaa tgtatttaaa ttatccacat tagttacttt tctaccgtat
     3541 cttgttaatt ctaaaatatt cctccactca tctttattag aaattactcc atattgagat
     3601 atcgtatgaa gtacttcata actcctagaa tcaatcgatt ttagaggtaa aaagaaaaaa
     3661 gtaagagaaa caaaaataat ggcacatgtg ctaataatat aaaaaagtaa atattttttg
     3721 atactcatcc tgttcatcgt ccttaacaag taatatacta caatatttca ccatacatgg
     3781 ctgttctaac taattctatt tttcatcaat gtacttcttt ctttatatct ataaattgat
     3841 tcattagctt ctggtattct tttagttgtt cctttaagca aatcgtaaat attccaccca
     3901 tgaaactacc aaaaataata aattcttttc ctacaaaaac ttgatgaaag tttgttagca
     3961 taacaaacat gaataaagca ttaaatataa aaaggttaag gaatagctga acactagaga
     4021 aatcttgttt ttcatcaaga gcaattggtt taaagaaacg atacataaca taatattcac
     4081 tgatcaatat tcccattaat aatatgcctt ttactattat cagccaaaaa aaatcgataa
     4141 aaataagatc aaaaaaaaca agtactggta taaacacaaa tagccatcga aattgataaa
     4201 catattggta aaaattatgt ctcttcaaaa aatccatctg tttttgaaaa ttttctttat
     4261 ccgttatatc catattagca tctccctttt ttaacgatta ctattgctta ttctatcgac
     4321 tttttcccta ttatttactt tgaataaatc ctctttttat tagtgttgtt aatatagacg
     4381 aagcacaccg caaaacagcg ctttcataaa ggacaactat aataagaaat aatagttagt
     4441 tttattaaat cataaataca gctaaaataa atcatacaaa agtcctaaat caagttttat
     4501 tttaagtttc taactttgat tgctttagtt aaaaatgaca caaccatctt atatcttatt
     4561 ccatacattt tcttattatt aaaatatata gttcaaaact taaaaagttt ctgacctgct
     4621 tgtttttagt tagaaatata acgcaactag cttgtgtcat attcaacata ccatgactgt
     4681 actcgaagaa ctgtttaaaa agatttggtc tactctttaa cccaagcttc cgtttcaact
     4741 tctccataat tgctcgccac aatgtattca taaggtaggc tgtctataat gttaggaata
     4801 tcgcgtactt ttattacttc cgttccatta aattttgtag aaacaataaa gaattctatt
     4861 tcttcattgt aatcattaag aagttgtaac atatctttat ctttactaaa aacatagtga
     4921 tcaaaaattt ggggttctcc atgattgaca tctgatacag agattacttc agccattgat
     4981 aatgcaattt cttcattgta ttctattaaa aatattccat gagctttatt acccttgtaa
     5041 atttttaaat tttgaatatg agtatctatg tttttcttac acgactttaa taggttttcc
     5101 tttaaatgat tattagaata cgttaatcta tgtctagcaa aagtatcttc atcgatcagt
     5161 ccttctttta tctcattact tcgactctcg aacattcttt gtctttttat atgctcggct
     5221 ccttttttca aagttctaca ttcttgtttt gtttgttgtt cttcattatt cattttctta
     5281 aactattctc ctgtcttttt ttaatattat gcttttactt tattttgcac gataatctta
     5341 ctccacaaca aattgttaaa ttagcattat taaatgtaaa aattgagtat actcatattt
     5401 tacacaaatg acgtatgccc aacttgaatg tcctactgtt tacctagtaa caattggaat
     5461 atgaaaaaga accaacacgg cataccctgt tggttctttt agttaatata ttttaataga
     5521 aaatttattt attacatcat gaaatactgt ataaaaatcg tagcaagcac acatcacttt
     5581 ttttagccta tcattttacg tcgacagtct agctggtttc ttatctcaat tttgaaccca
     5641 ttgtttttct gctataatca tagttgacgt ttgatctgaa taatttttta tgatattgct
     5701 aaattctgtc attgattggc ttatttcatc atcagcactt tttgagcatt taaagtttag
     5761 atatttaatt ctagatctac taattgagtc tagaattttt aaattaattt ttttaaaagt
     5821 ttgtttatta tctacagata agatatattc tatcatatac aaattagcta aataaaaatt
     5881 ctgtaaataa cttttattat tcagtatctt gtcttcttta ctaagtattg ggtatattag
     5941 ttttaatttc ctattatttt tgtctattaa atactcatat ataacataca gtaagaatgt
     6001 atttagcaca tataatggta attctttatt tttttttatt attttgcata cctcattgct
     6061 atttaagaaa gttgactgat tatatttatt aagtaagcta tttgatacaa tataatacat
     6121 ttcgaaaata taatccttag taactaattt atatatattg tatccatcat tcataaaccc
     6181 gttaaaatta aaaggaactg cagtaatcaa gaatattgaa aaattaaata aagaaaaata
     6241 ttgaaaaaat tcaattttta caaaaaaagt taatgtaaaa aaaagactaa atattggtcc
     6301 tccggttaac aacctcagaa ttttcttatt attaaacgta gttggcttat atctaaataa
     6361 tccaccaaaa aatccccact gtgtatttaa tctaacctta aactgttttt cccacgaaag
     6421 ttttataaac ccaaatatta atgactctgg tctaacttta ttaaataatc caaaaactaa
     6481 atgacctaac tcatgtacaa agatagacaa taacaaggaa aagtatgcag tagacactaa
     6541 atttaattca aaaacaagag taaagattac gagaagtaac gtaaagatca tcggagatat
     6601 aaatttcatc tattttattc tcacctcttt gtatttaagc atgctatttt tatctataaa
     6661 agaatcagca ttttcaaata aagtatttaa tacttcattt gaatctttag aattatctac
     6721 attctttgac ataatagctg ctaaagctgc gcttacttct ggagttgcta aacttgttcc
     6781 aaaagaaagt gtataaccat ctggaaagtc agcagctttg cctagtggag aaactagcga
     6841 tgtagggtaa taagtcatca tcatttcacg agcatcaatt tgtcctgtta ttttgtaatt
     6901 gtcaccatat cctcctgcag gaccatatat agatacatta gacccataat tagaatagtc
     6961 agcaatatca ccactctttt ttgtagctcc gacggtaatt acagactcta gtcctcctgg
     7021 tatatgtttt tcattaccag tgcttatatc acgcgactca tttcctgctg atgcaacaat
     7081 tagaatgtta ttttttcttg catagttaac agcttttctg aatgcttcta cagtaaatct
     7141 ttcgtcgtct atttccatat ttttatatga tccaagactc acatttatta tatctacttg
     7201 atcatttgta gcatcaacta tagctttaag catatttata gagtttccat ctgtcccatc
     7261 catcacctta taagaattta aatttactct tggagcaatc gtgtctatta ctccagcaac
     7321 ttgtgtacca tgaccatatt catctaactc aatatcatta acatagtttt ttaatcttag
     7381 gttattgtct tgaagattag gatgaagcct atcaatcccc gagtcaatta gagctatggt
     7441 tatatctttc cctagttgtt ctttcactgg atcaatatga gataaaattt ttttatatgg
     7501 ccaattaaaa gacttaaaat ctttgtttaa aatattaatg tttaaaatag aactattaac
     7561 ttcttcaggt ttaaaatctg gtaatttttt cccttccgaa acattaaaat atttacctat
     7621 aaacttccta tcactatcat ccaggttttt aaaactaact aatcctattt cctgtatata
     7681 atctactttt tcagaagata attcagactc aatttcttct atagcagttg tttgcgaatt
     7741 atcaataaaa aatgaaatat tatttgagag atctgatgca taacctgttg ttcctaatgt
     7801 taaaaaaata tatgagatta aaatataagt caatcctctt tttttcattt tgtacctcca
     7861 aattgttgtt ttttgtaata cagtgaacga tataactcgc tattttcaat aagatcttca
     7921 tgctttccaa tacatactat ttcaccatta tccattaata taattttatc aaagtttctc
     7981 accgtactaa ttctgtgagc aacagtaata actgttcttt tctcatctaa taaattagaa
     8041 aaaacttcaa attctgaaat attatccatt gcagatgtag gttcatctaa aagtaatgta
     8101 ttcacattag aatagaacgc tctagctaaa gcaatctttt gcctttgacc accagagaaa
     8161 ttactaccat tttctgatac tatagttttc tcatactgag gaattcctaa aagtacctca
     8221 tccatttttg atttactcat actttctttt agtctttttt tctcatttat agaagaattc
     8281 ggtttaaact ctaaagaaat atttttttcg atagtttcat taaaaatatg cgcattttga
     8341 ttaacataaa aaatgtttct tctattattg gagttgtttg ataaaggata gccttcatac
     8401 aatatttctc cattagaagg ttgtaacaat ccagccaata gttttagtaa agtagatttc
     8461 cctgacccac ttctaccaac aatagcaact ttatcccctt ttcttatgtc aaaagaaata
     8521 ccatttaaaa tatttttttc aaaaacagat atagtatagt aaacattatt aaccctataa
     8581 ataaactctt cttttccaac atttcctttt ttattattaa aatcattttt ttcttcataa
     8641 gttaaaactt cagataattt ttgaaaatat acatttaata gtagaaagtc attataagag
     8701 gaaaccaaac ttagaattgg cttcataacc attgttacta tagaaacaaa accaattagt
     8761 gatcctaatg acaaagaatt gttgattatt aatttaatac ctattattaa aaatagagct
     8821 ggcattacac tttgtatgat ttctggtaat attccaaaaa tagctatata tctattttta
     8881 ttttttgtaa ttaatagttg agacgtaaac atgtttttcc aatttaacaa aaaactcttt
     8941 tctgcattag cagatttaat ggtttcaatt ccttcaattg cttctgtaat aattctctgg
     9001 acgtttcctt gttccattat ttctttatct acaaatcttt ttattgtatg cgaatttata
     9061 atacttaaaa aagctattaa agagattaga acaagagcta ttattgtcag taaaatagaa
     9121 tagttaacca ttaaaaacaa atatatccct aaaaaaagac tatctattaa agttgttatt
     9181 accttttgag acaatatttg cctaatataa atatttaagt tcgctctaaa cactaattct
     9241 ccagttgatc tattactaaa atacattagt ggcatactaa aaagtttatc aatataagaa
     9301 aacattaatt taaaatcaaa ttcatactga aattctgcta ctacagagct ttttaagtat
     9361 tgaactacat ataaaacaga aaaaaaacta gttaatatta ataacagaac ataggtagga
     9421 atttcttgaa aagatctaat attatctatc gaatactttg ttgcaatagg aattaagagt
     9481 aataaaagtt gtgaaacaaa tgataatatt attaaactaa agaaatatct tttgaatttt
     9541 gtaaaaataa atgactttaa aaaaaactgt ttccttttgc cttctttttt agtctttttc
     9601 ttatgtgcgt atattaatat atttgaaaaa ttttttttga attctgaaat atcaatccag
     9661 cgtttattac ttgcaggatc taagattaat actttcttct tttttatttt ctctatgacc
     9721 acaaaatgtt gattattcca ataacttatt acaggagtcg gaagatctaa ataatttgaa
     9781 aaacttgatt taaatgtcga tacatcaaat ccatattcgt caaagacagt acgaatattc
     9841 ttgatagtta gtcctccttt gggcacccca tatttttccc ttagttctac tagtgtactt
     9901 tgattaccat aataattaag tagcatagtg atacatgcca aagcacattc actatgctct
     9961 ccttgcgcaa cgtacttcaa tcttttcata attacacctc ttataactca aaaagtaatg
    10021 cattcggaat ttcagaatct aggtttctca ataattcata acccacacca ctgattccta
    10081 caaagaatcc tagtgattct aaatactcac ttccggcaac ctttagtgta ttattttttt
    10141 caaaatcatt tagcatatag ctaataagtt tatttttttt atactgataa gtttcaggat
    10201 cttttttagc taattgaatt agcccttcta aagtacctgc atttccatgg cacagacaat
    10261 ctttattttt atatgctatg gttttattaa tatctatatt tgaaatgtta tcatcatata
    10321 attcaattgt cgctaaaagt tcacctacag ttcccttaca ccaactattg tttttaggtt
    10381 cttcttcaaa gtatgattct ttaattttat gaagtaaaga atttgcctta tctatcctat
    10441 tgaattttga tagaagatgg acatagctat atataccgtg tccgaatcct ctgaaattaa
    10501 aatagggttc ttcggataat ttttcaaaaa tttctaatga aaattttcta tatttttcat
    10561 cctctgttat ctcggataac aataataaaa cttttattat actattatgc ccgtggatcc
    10621 aatcattttt taactcgcca ttatttatcg gtttcttttc aatcaacatg tctgcaattt
    10681 ctacggctac atttaaagag tttatatcat tatttaagcg gtaatctaca agtaaaggat
    10741 atattaaact tccttttcca aaaaaagctg acaatatatc ttcagatggt attgtataaa
    10801 ttgaattttt tatacattca attacatagt catatttatg attctttgta atgtatttaa
    10861 gagccacata aaatatgaat ataccaggca atccatcgta catattatta tttaggattc
    10921 ccacattcca atcttgatcc aactttatgt caatccaatt tacagtattg gtttttttat
    10981 taaaaatagc tctcttgaaa atttttttct ctatcttctg acatgcttga ataattttac
    11041 cgtttagctc taagccagta taaatatatt tatttgaatt ttgatttttc aaatcattaa
    11101 tatatttata tggattataa atattcaaag caatttctag ccaaacggtt tgaatagaaa
    11161 tatcttcatc acaaagatca tttattttat ttaggcatct attcagagcg ctttcttgat
    11221 aaaaatcttc tactaagcac ccgtcactag ctattaatga tgtttttgag atattgttat
    11281 aaaaaatggg tatgtctcca tctattaagt ctgaaaattc gtaatgaact acctttttat
    11341 tcttatatgg ataggcccac atattatgaa gtactttttc tctctctatt gcattagaaa
    11401 agcaattagg atggtatgaa aattccaaca tatcagcata tctttgagtt ggtctgatta
    11461 catttctaac tataagattt tgtaaattat tattaatata tgccaatatt tttttcttag
    11521 aatcctttgc tttcattaaa atacttttca taccagtaac tatatatttt tcatagctga
    11581 taaaactaat tttttcatta ttcataattg gagtattttt tgcagtatcc ataatgtgtg
    11641 tttgatattc aaaacgcatt tcatcagtaa atgtattttt aatttttaat atcttgaacg
    11701 gtacgctttg ctctttaaag tttaacgcac taaggttaac cccttcatcc ttcgaatctg
    11761 acttatcttt catcgctaaa tatggtacta gccctgtcac cattatagaa tctaaatatt
    11821 tatatttagc atctactgtt gcgctattac caaactctat aggaatattt tgttgaaaaa
    11881 aagtttcgtt atctatgata acagggtatt ctccatgagc gattatattc tcatagtgta
    11941 agtctgtaac attaaataag aaagctattc cgattagttt accatacctt tcataatatt
    12001 tttttacttc ttctatgtta tttatttcta tattatctat atattcttca tagaaatagg
    12061 tatttctagt aactttttta actatataaa tatctgcctc taattcttta tttaaaaatt
    12121 caaaaaaatc tcttaattta ttctcgctat taatctttgg cttgtatact atcttctttc
    12181 catcagaaaa agttagtgta gaaacagttt ttccgcgact atgagagtct ccctgtgatt
    12241 ctgatataga gttaagctct gaggattgta tgttaaaaca attttgtatg ctaggtaaat
    12301 cttcagtcac tcttataagc atttgtttag tattatctaa aaaatatctc attctaacaa
    12361 cagtaatacg catcaactca ggatagcatg tataaaaagc tattatatct tttttagagt
    12421 taaatctttt ttttagataa tagataaatc gcttgctact atcatttccc tttagaggtt
    12481 catttttttt aaaagtatgc aaatctagca ctaatgtttt acttgttaag tgaataagct
    12541 cttgtgttaa agtttctaat aaattaataa tgaattcttt tgtacaaata tttaactctg
    12601 agtttaaatc aagtaaaaat aaacgagcat actgtaagaa atatctaaaa ggataactag
    12661 catctacttc taataatttc tcttcactat cattataaga atctaaaatg gattcaaaaa
    12721 aaatatacca tgattgatct ttaatgtatt gaattgcaac ttctttatca ggaaagtttt
    12781 caataggtgt tattcctaat ccaaaattat ccagtgattc atatttatat ttaatcaagt
    12841 agtctaaatc atcttgttta agaacacttt ttctttcttt ccaagcttgt aaatttttaa
    12901 tgtcgtactt ctctttacca ctttgcttta gtaaaaaaca tctttcattt atgcttaaaa
    12961 catttattaa attatcttcc atgtaagcac tcctttttta tgtataagag ggctagtttc
    13021 actagccctc ttaatatata aattagcaaa atttagctga aaataatgca cctactccta
    13081 agcctatggt gaaacatgct ggagttgtct cagcctgaac atctccacta ccttgaatcg
    13141 cttccatttc ttctaaactt aactcttcaa aagaaggacc aacaagttct aatttattag
    13201 agtaatagtt ttcttgattt tccttattta gcactgtgct tcacctcact aagttttata
    13261 gtatatttta acaatgtttt aaagacacaa ctacagttac tccagtaaaa ataccgccac
    13321 caacccagcc acaagcagca ctacttgctg cagctgtcgc cgcaacagca cacaccggtg
    13381 ttgtctcagc ctgaacatct ccactacctt gaatcgcttc catttcctca acacttagtt
    13441 cttcaaaact aggaactaca cttaaatttt ccataattct taccctccat cataaaattg
    13501 ttgtatattg cataacataa tatgttacaa tttaatatta tagagctttt aatcttttgt
    13561 caagtgacac ttgacaaaaa ggaggaatca aaatggctat ttttattttt ttattggata
    13621 tcatttctgt agtctacttt gtttttaatc tgactgattc aaaaaaagat gagcgaattt
    13681 tatatacaat ttctttaaca tctacttaca tgtacttatt tattaacttt tccatactta
    13741 tagtaattgc tatttttctt ttactaccta atgttattac taaaaactat ctatttaatt
    13801 ttatctacta ttacttctct ctatcaatga tattgcactc tctgttacta ctttttttca
    13861 acaagaggac ttcataaatg ataatcaata acttaaaatt aattagagag aaaaaaaaaa
    13921 ttagccaaag tgaattagct gctttattag aagttagcag acaaactatt aatggtatag
    13981 aaaaaaataa atataaccct tctttacagt tagcattaaa aattgcttac tacctggata
    14041 ctccactaga agatattttt caatggcaac ctgaataaaa aagattttta aatttcacca
    14101 cagaatattt aaattaaaag aaaggtgctt cgtatgaaga aaaagtttat atcccttctg
    14161 attttatttt taggaataat tgttggcata gtaacagttt atattttaaa gcataaataa
    14221 ttatgactgt tgttttatac tttaatcata actgattttt tatcagtaaa accctcactt
    14281 atgattacat tcatttaaat aaaaactagg ctcaaatgta tagtaaagac tatctctttt
    14341 tttgggggag acagtctcta aggttataac ttattttagc ctttcaattg ccttgatatt
    14401 acttttattt caagattatt taacatggac aaatacttct gaatctttta cataaatgtc
    14461 gtggtaataa ttagatttca ttaagtcact ttcttcttta ttcaacgcgt taatatcaaa
    14521 gatctccatg ttcacattta agccagtgta cgttctaaat aaaaactgat ttggccaata
    14581 aagggcttca tttggtggaa ccagttcttt taatatagga taattcttcg aactattgac
    14641 aaatactggc gaatccttaa ataaagaggt actatgcacg gtcaccgtgt cacggttcac
    14701 tagatctttt aaatcaccgg ctaatatcat actttgtcgt tcaaaagatt ccttttggtg
    14761 acttaacgca ctagcataaa caaatgtaaa agataaaagg taaacacaga aaaggcaaac
    14821 cgctgttttt gacacataac ctaccgcggg ttctgttgca aagttttaaa taaagaataa
    14881 aatcccttac ggtatctatg atttaagctg ggattcccaa taataccttg atttcagtac
    14941 agaccgaaaa cccgaagaga gtaccttctt ttcgggtttt cttatataat cctcgaatgg
    15001 cttccatgcc tttaatcgtg gtagaggcag tgcgtaaact tcgatagaat ttattgcgtc
    15061 tctttactgg acgatggtct tgttcaatca aattattcag gtatttaatg gtacgatgtt
    15121 ctgtcccttg ataaaagccg tattctttta gtttcttaaa ggcacttgta atagaggggg
    15181 ctttatctgt gactacaacc ttcggttcat caaactgctt cactaaccgc ttaagaaaag
    15241 cataggctgc ttgtgtgtcc cgttttttac gtaaccaaat atccaaggtt aaaccatctg
    15301 catcgatggc tcgatacaaa taatgccatt ttcctttaat tttgatgtac gtttcatcca
    15361 ttttccatga ataaaaggat tgtttatttt tctttttcca aatttgatag agtagtttgc
    15421 catattcttg cacccaacga taaatcgtca tatgagaaac gttaatgcca cgatcatata
    15481 agatttcttg aacttcacga tagctaaggt tataacgaag atagtagccc acggctacaa
    15541 taatcacatc ctactgaaat tgctttcctt taaaatgatt caccgtcatt cctcctgcta
    15601 tctttttcta ttattctacc ttatttgata gtagatttaa aactttgcaa cagaaccgtt
    15661 accacaacac attcacagaa ttccgcgcga ccgcaacggc gagttcaagc aacagactgt
    15721 tcctgcttat agacggacga atgatacctt agaggagacc gtcattcacc tcttccgaaa
    15781 aggtattacc atgtcggaaa tcgcagactg aagaagtaaa tgcatttaaa gttagaactc
    15841 taaatgataa gtatgtcgct attttcatgg atgctactta tatttcttta aaacggcaaa
    15901 ccgtctccaa agaagcaatc tatattgcca ttggtatacg agaagacggc actaaagaag
    15961 tactaagtta tgcgattgct ccgactgaat cgacctacgt ttggaatgag ttgttacagg
    16021 acatttactc cagaggggtt catgatgtct tactgtttat taccgatggc ttaaaaggca
    16081 tgaaagatac gattcaccag atttatccta aagctaaata ccaacattgc tgtgttcacg
    16141 tttaccgtaa tattgctcat aaagtacgtg tcaaagatcg aaaagaaatc tgtgatgatt
    16201 ttaaggctgt ttatcaagct agctcaaagg aagaggcaaa taccttttta gggagtatga
    16261 ttgagaagtg gcagaaaact tatcctaaag tgacgcagtc actgataaaa aatcaagatt
    16321 tattgacttt ttatgagttt ccgcctggta tccgccgaag catttactca actaatttaa
    16381 tcgaatcttt caataaacaa atcaagaaat acagccgcag aaaagagcag tttcaaaatg
    16441 aagaatcact agagcgtttc ctagtatcca tctttgatac atacaatcaa aaattcttaa
    16501 atagaagcca taaaggcttc caacaagtga cggatacatt agcttcaatg tttactgagt
    16561 aacccattat tttgcagaag gacgagttat ttacacaaaa ttattgacgc tcccggttgg
    16621 tacaacaaga attgcagtag catagtcacc attgatgaaa ctacttaatg attaaattga
    16681 gcaatttctc aaatagcaca aactgctctt cataaaacga aaagcagttc ataatgtatt
    16741 tagatatttc attgtgctat tgaccagaaa cacactattt aaggtacctt tctcttttcg
    16801 ctgagattca ccaacttcaa ttgcacaaaa aagcgtgagc acaaggctca cactttttct
    16861 agttgactat cctaaaaatt cgaaaacatc tttacgatca tacaatttca agattttttc
    16921 aaataagatt tgacctacga aagcagctac gattggtaca acaaaccagc tgattaatag
    16981 tagaataata ctcaaaccgg cgtccaatga agccaacgga cctaccaacc ctaccaaacc
    17041 gaaaccagca gaagcaggag tccctgagac tgagaataac gctactggaa ttgctgagat
    17101 gatagcggtg aatagacatg gcaccaagat aattggtttc ctaaacaagt ttggcatcat
    17161 cattttcata gcacccaatg cgatggccaa agtaacccct ggtttgttga ctttccaaga
    17221 gttaactacc aagacaactg ttgttgcggc aacacccata gcggctgcac cagcagaaac
    17281 accgttcaat tgaattgcca taccaatggc aactgtagag atcggcgaga taatcaagaa
    17341 agcaaaggaa catgcaatca agattgacat caaaattggt tgcaaagtag taaaggtatt
    17401 aattaagtca ccgatagcgg cagtaatctt ggttacgtaa ggatataaat aatagccgat
    17461 tagaccagcg ccgataccaa caacgattgg tgttgcaaca attgccacgg acccaaattt
    17521 ttcgccgatc aacaagatca tgccgacagc gattgatgca gtaatcatgg tattgatgat
    17581 gtctccggta ccagcaccga tataagtagc tgtgtcagga ttgaatttca caacaccgga
    17641 gccaacgaaa gctgcaccgg caactactaa catttgcatt ggtttgaagc caaactgcac
    17701 cgcaatcaaa gcgccaatca atagtggagt agctagttgg aaaataactg ccatttgtgt
    17761 gatcgttact gctaaggtat tttcaccaaa taatttcaaa attgctgcca ataccgcgtt
    17821 aggaatcaac cctacgatga tccccgttgc ggtacccgct aatactttat ttaaaaatat
    17881 ttttggagtt aatttttctt ccattttctc atcctctttc taatgattac tatttcgctc
    17941 ctagaatttc ttctttacta tgaaccagtt gcgttaagaa atcacagtaa ggagttacta
    18001 ctccatattt tttaccttta cgagaaatgg ctccgttgat gtagtcaatc tcggtcaaac
    18061 ggttattttt tatcaagtct tggtgcatcg atgggaaatg cataccaatc gtagtcgggt
    18121 caaaacaagt ttctacatgt tcgattactt cgggaatgtc taagttgacg ttttctttgg
    18181 cagcaacagc tgcaaattcg ttaacaatag tcactaccat gtcatgagca ggtttggttg
    18241 caccaagccc cgccatattg acgtctaaaa tcgtgcataa gccattcatc gtaccattga
    18301 cacaagcttt acgataaatt gaataatgaa tgttgtcgga atatttggca tttaaaccag
    18361 acgcggacaa agtttccgcc aattttttcg ctgattcttc ttggccaata cctagatttt
    18421 gcaattcaac agacccgctg ccaaataatt tagccttgcc gggaccttct agaccagcag
    18481 tccacatggt gttgccgata aagatttttt ccatcggtac gaatttttcg attacgtctt
    18541 catgaccgat accgtttaaa agacacaaaa cttctgtgtg atcagcaatt aatggtttaa
    18601 catcctgcag cattttttcc aactgcattg ccttcgtgaa taagataatc aaatcaaatt
    18661 gctcaccagt gggcacctca ttctgattaa caattgagac tttaacagta atttcttcgc
    18721 cattataatt agccttcaat ccgttttctt tgatggcatt gatatgctcc tgccagccgt
    18781 cgattagcaa aacatcgtta ccaccttgtt tcaacatcag tccgaaccgg gaacccatcg
    18841 cgccggcccc tgcaattgca attttcataa ataaaagcct ccaaacttaa tttataataa
    18901 gtgaacattt tcacatttct cattatagag ttttcattcg gaaacttcaa gtaggagagt
    18961 gtaaaacttg cgaccatgct tttataaata cttaattaga ttctcttttt aaaaatgaat
    19021 gctgatccta ataccattaa tgaacctagg acagacaatg caatattttc tgtttctcct
    19081 gtttttggta aaactttcat tcttccgtct gaacctttaa ccgttactgt tccgtctttt
    19141 tgaacgtctg ctccaatttc tttagcttca actttctttg ttgttccgtc tgctaattga
    19201 ataatcggtt tactatcttc aactgcgaca atcacaacgc ctgtatctgt attaactggg
    19261 ttttcgtttg aatgcttttt tcctagcttt tcttttattg ataatttaaa atataaatca
    19321 aacaactatt gtatgacaat aacgggagga tcctatgaaa gaagataaaa tacatgtttt
    19381 aagtttattc atatctagta tagttttatt cttaataaca attatttttc acgaaattgc
    19441 tatcggtctg gttatcgcat taatttgttt tcccattagt aattctattg caaaaaaagg
    19501 ttctgttgca aagttttcca aaaaatctat tttagtgtaa aattgagaaa aaagacagag
    19561 aggacagagt aatgaatcat tttaaaggca aacaattcaa aaaagacgtc attattgtcg
    19621 ctgttggtta ctacctgcgt tacaatctaa gctatcgtga agttcaggaa ttgttatatg
    19681 atcgtggaat aaatgtttgt catactacga tttatcgttg ggtgcaagag tacagcaaag
    19741 tcctctatga tctttggaag aagaaaaata gacaatcctt ctattcatgg aaaatggacg
    19801 aaacctatat caaaattaag ggacgttggc attatcttta tcgtgcaatt gatgcggacg
    19861 gcttaacctt agatatctgg ttacgaaaga aacgggatac gcaagcaatt gtgaccgata
    19921 aagcaccttc tcttggctcc gcctttagaa agttacagag tgtgggttta tatactaaga
    19981 cagagcaccg aactgtgaag tatcttaaca atttaataga acaagaccat cgacctatta
    20041 aacgacggaa taaattttat caaagtctcc gtacagcctc ttccacgatt aagggcatgg
    20101 agaccattcg aggaatatat aaaaagaacc gaagaaatgg aacgctcttc ggattttcgg
    20161 tgtctactga aatcaaggtt aatgggaata ccagcctaag atatttggag ttcagagagg
    20221 gcgcgtttga ttttcaaact ttgcaacaga acccttcact ttatcgacaa acgctataac
    20281 aaacggattc atttgtaatt cattttcatg cgcataattt atttctgctg taaaaattgg
    20341 tacattactg ggcaccattc ctaaaactga cgcagaaatc attaaaatag cacatacttt
    20401 tttcatttcg attcaaactc cttcacattt tttagtcttt taaataaata ctaatacacc
    20461 tatcacattt ataactctat atttttttta cacttcaaaa aaattatgcg gacaatcgta
    20521 gttactctta taacaagcta ttcttcttat taaaaaatta caagtgttta ctattcattt
    20581 ttttatagaa aatatgaata caaaaaaaca actattcgtt ttataagaat agttgttttt
    20641 gatattaatt gttaaaccct ttttttctca aaaatccact ttttcatgta atactgtact
    20701 tttttgtcat ctttccttaa agcatctaat ttgtttaatt tatcatcaat tacctagtag
    20761 ttatcaataa cttaaatcta ctcttctatt attcccgttt atttaaactc atttcgaaaa
    20821 tacttataaa aacaagaatt acaacaaatt aattagcata gttaatttgt tgtgtttcca
    20881 ccattggata aacaattaag ctatccttct ctaaattttc cttattcata tccacagcag
    20941 taatttgact attgtcatac gtacgatagt aataaattcc cttttccagg ttacaacatg
    21001 aagaataaat cgtatactca tatttttcat caccaacatc acacaatcct ttttgttgtt
    21061 cgacagaact taaaatatga aaaaattggc taatactttc atattctgaa cttcttgata
    21121 cagaatttaa cttagtaaaa gttgctttta caaatctaga tactgatgat aaatctcctg
    21181 gcaacccaat accacccatt cctctactat aaatatctaa ctctatttga tctgaaaaat
    21241 tattttttgg agttctagtt gaaagtacac gataattgtt taaattaaat aattggtaat
    21301 caaatgttgg gttatttgtt aatacgccta caggattatc aaatacacgt aagccttctt
    21361 tcgtgctttc aaccacaata gattgctctt tatcagccaa cagccaatgg agaggggata
    21421 acggaagttc atcactaaaa ttaatattta ctaaattaag attcttcaat aatttttttg
    21481 cttcatctac agtagagcat tggcccaata cccaaggaat aaactcaaat ggagaaacat
    21541 tttcttttcc ttcttcaatt tttttataat ctgcatagcc tgaaaagttt aatccagcca
    21601 ttcctaatcc tttttcattt attgcatcat aataaagcgg ataatcagca atcccagcag
    21661 caattccaat tattgcaaaa tgatgatcta aatttccaac ttctcgaaat gaaaacttat
    21721 aatttctcgg cgtaatagta accacctcat tataagaaat ttcataatca aaattccttc
    21781 caaagtaatg atcttttgat acataagtaa ttgctgtaca cataatcaat tcctcctata
    21841 tactaattca gtcactaaaa tagtacaccc aatactcttt tttatcaaat ttaacctatc
    21901 cacaaaatgg ctaaacaata tatgaacatt caatttggtt ctgttgcaaa gttttaaatc
    21961 tactatcaaa taaggtagaa taatagaaaa agatagcagg aggaatgacg gtgaatcatt
    22021 ttaaaggaaa gcaatttcag taggatgtga ttattgtagc cgtgggctac tatcttcgtt
    22081 ataaccttag ctatcgtgaa gttcaagaaa tcttatatga tcgtggcatt aacgtttctc
    22141 atacgacgat ttatcgttgg gtgcaagaat atggcaaact actctatcaa atttggaaaa
    22201 agaaaaataa acaatccttt tattcatgga aaatggatga aacgtacatc aaaattaaag
    22261 gaaaatggca ttatttgtat cgagccatcg atgcagatgg tttaaccttg gatatttggt
    22321 tacgtaaaaa acgggacaca caagcagcct atgcttttct taagcggtta gtgaagcagt
    22381 ttgatgaacc gaaggttgta gtcacagata aagccccctc tattacaagt gcctttaaga
    22441 aactaaaaga atacggcttt tatcaaggga cagaacatcg taccattaaa tacctgaata
    22501 atttgattga acaagaccat cgtccagtaa agagacgcaa taaattctat cgaagtttac
    22561 gcactgcctc taccacgatt aaaggcatgg aagccattcg aggattatat aagaaaaccc
    22621 gaaaagaagg tactctcttc gggttttcgg tctgtactga aatcaaggta ttattgggaa
    22681 tcccagctta aatcatagat accgtaaggg attttattct ttatttaaaa ctttgcaaca
    22741 gaaccgatcg ttgcgccctg gtcttgcatg actatttttt attgtgttaa aattactagt
    22801 acaatcgaat aatcaaaaaa acactactat tcgtctggtc gtttagtagt gttttttatt
    22861 gatttgtaat atctttccga ttcatcgaaa taattcacta tgtgagccta ttcgagctaa
    22921 agttaggatc aatttatcac cgtcaatttt ataaatcagt aaccaatctg gttcaatatg
    22981 gc
//
