LOCUS       NZ_CP116962            20729 bp    DNA     circular CON 10-MAR-2024
DEFINITION  Enterococcus faecalis strain DM86 chromosome, complete genome.
ACCESSION   NZ_CP116962
VERSION     NZ_CP116962.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 2959291)
  AUTHORS   Shen,W. and Cai,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JAN-2023) Clinical Microbiology Laboratory, The Second
            Affiliated Hospital of Zhejiang University School of Medicine,
            Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v.0.4.4
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore
            PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/10/2024 16:14:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,086
            CDSs (total)                      :: 3,005
            Genes (coding)                    :: 2,954
            CDSs (with protein)               :: 2,954
            Genes (RNA)                       :: 81
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 18 of 51
            Pseudo Genes (incomplete)         :: 29 of 51
            Pseudo Genes (internal stop)      :: 12 of 51
            Pseudo Genes (multiple problems)  :: 6 of 51
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:47:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1399348
            Orig. end                         :: 1420077
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116962.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20729
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="3"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20729
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20729
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10729](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10729
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    2..16
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.5"
                     /tool="antismash"
     gene            163..558
                     /locus_tag="PO880_RS06715"
                     /old_locus_tag="PO880_06715"
     CDS             163..558
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002407764.1"
                     /locus_tag="PO880_RS06715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06715"
                     /product="hypothetical protein"
                     /protein_id="WP_025191811.1"
                     /transl_table=11
                     /translation="MDGMFANLTLRERRLLKQAQLGATISFILLFVPILTISLLHTSDL
                     LAKWLGIVGVIMVLPLLYFAWQILKIAYKDQKDNPTPPLWVPKVYGIGLSINPYHRFGK
                     LIFILLAVLIVGIIISLLFTPASQINH"
     gene            1062..6689
                     /locus_tag="PO880_RS06720"
                     /old_locus_tag="PO880_06720"
     CDS             1062..6689
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016633936.1"
                     /locus_tag="PO880_RS06720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06720"
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="WP_025191812.1"
                     /transl_table=11
                     /translation="MGSNFKEEKMNKEYQGKKIYGKKHWLTFLLVSSSVLAFHSFVTMD
                     SQVVDAQEQTAKEDVADSATSVGAIVSIEKAEKNFVITYASGKKAQISILNDHLFRYHL
                     DPTGKFEEYPTPNDPKHVAKITAKTMADYGTQAFEQTNVTDSGNQFILENNGLKIIFEK
                     ESALMKVLDKKKNQVILEETAPLSFKNDKATQTLKQSSQENYFGGGTQNGRFTHKGTAI
                     QIVNTNNWVDGGVASPNPFYWSTAGYGVVRNTWKPGNYDFGSHDPQTTTTTHEGTDFDA
                     FYFFNDSSAGILKDYYELTGKPALMPEYGFYEAHLNAYNRDYWVKVAEGTAGAVKFEDG
                     NFYKEYQPGDLGNLNGTLESLNGEKENYQFSARAVIDRYKKNDMPLGWFLPNDGYGAGY
                     GQTDSLDGDVQNLKGFTEYAQANGVEVGLWTQSNLHPADPKNPKKGERDIAKEVSVAGV
                     KALKTDVAWVGYGYSFGLNGVEDAANVFVKETDGAVRPMIVSLDGWAGTQRHAGIWTGD
                     QTGGQWEYIRFHIPTYIGTSLSGQPNVGSDMDGIFGGKNKEVNIRDFQWKTFTPVQLNM
                     DGWGSNPKTPFAFDQEATDLNRAYLKLKSMMMPYNYSIAKESVDGLPMVRAMALEFPNE
                     GTAYTKDSQYQYMWGPNLLVAPIYNGNQDEAGNSIRDGIYLPDEKQVWVDLFTGEKYQG
                     GRVLNGVKTPLWKVPVFVKDGSIIPMTNPNNNPKEIQRDQRSFLIYPNGTTSFNMYEDD
                     GISTSYEAGQSATTKINSQGPKSNEKGDLTVTIEPTKGSYKGFVDERSTTLDLLASEAP
                     ESVTAMVGGTEVTLKQAANKEEFLAGTNLYYFDKEFQVNQYLSEASGEKLNQSALSVKL
                     AKQSVTAKDVQITVKGFINKGTVDGGNTTVDDQLTIPANVAINEEKTTPSSLTLQWDQV
                     TEATSYEVERDGTVFGNIQTNTATFDGFSFLSEHTFRVRAVGKNGVSEWSEPIKGKTQD
                     DPYKETINQVKATSNLPEQPGAELKKLTDKDLSTGWHTNWSTGIANPSDGNFLSLKFDL
                     GAEYQMDKIEYLPRDNAGNGNILQLQYRTSKDGANWTEFSEPINWKQDALTKTIETKEQ
                     AYRFVEMKVLKSVGNFGSGREMLFYKQPGTEGILHGDITNDGTIDENDAMSYRNYTGLE
                     SVDSDFNGYVEKGDLNKNGVIDAYDISYVLRQLDGGIEIPDVEEIAGGLSLAVVNENGK
                     DTYLPGDTLTFTLKGQDLKNINALSTKMSFDSSKFELVGQPATTNNTKQMENYSKYRKH
                     SNDVENLYLVLSNQGNKQLLNGSMDLVTFKVKVKETTRVKRATTVEQPLQFDMSQGLLV
                     GQGFQQATLSDFSVTVKPTELVDKELLQALITLNQARVEKEYTPETWAIFKPVLDEAVA
                     VLANEQATQTDVSAAVENLEKAASQLEKMPDVANKADLEKAIQEGLAKKPSDGQEFTEE
                     TKKVLEDSLAAAQKVFAQEKVTQEEIDQATKTLREAIAQLKEQPVAVDKETLKEKIAQA
                     RGRKPEEGYQFTKETEKQLQEAIQAAEAIVAKETATKEEVSEALNALETAMAQLKEVPL
                     VNKDQLQEVVKRAQQVTPSEGHQFTASSLQDLQKALLAAKNTLENPAANQKMIDEAVAE
                     LTSAIDGLQEEALVTDKKALEAMIAKAKAIKPSAGKEFTSESKARLTEAIDQAEGILAD
                     KNARQEQIDTAEKNVKTALDSLEEQVLQADKTKLRELLQKAETLKPKAGKQFTKASQEA
                     LAEAIKQAKALVEDPSATQEAVDKCLSILAQAIEAMAEEPISSNSTGNNRNHGTVSGTG
                     SVTSPGKGTAAGGTTTKTTTSGTLPKANEVVSPIWSISGFLLIVSIGLGKLFFKNKKDQ
                     N"
     gene            6771..8762
                     /locus_tag="PO880_RS06725"
                     /old_locus_tag="PO880_06725"
     CDS             6771..8762
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401391.1"
                     /locus_tag="PO880_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06725"
                     /product="amidase domain-containing protein"
                     /protein_id="WP_010710272.1"
                     /transl_table=11
                     /translation="MKRKKIKNQLLVLTSILVLLSLEVAPVVTLAAELPSSSLQTALSS
                     ETTITSEEKVIETTETTETTETTVATSTTSTSSSSSESNSSTDTTTESTSHSTTETTTT
                     NTSSETKKEPTEPTVSSEITQPIEQSQPPQVQPPQVPVTKQEPEEPIQVPEATNNVVEE
                     NQAVSLNPSLKVDEIASSNLKGYELPLLSSFGEKKRAVVVAEALRHIGKTKKEFNLTEQ
                     ALTSSFLAQKIYQQLFKIDIGSTPQEQMTFGKVRSIEEAEPGDLIFWQTAEGKTLQNGV
                     YLGQGKYLIAAAEADSKEKPEVIAQLENIYTAKQQPDSKEEKRLVVTNPFKEFILTEYG
                     KEVLATYGASFEMQKSEQTTAFIKKIGETARELGEKYDVFASVMIAQAILESGSGESQL
                     AKEPYYNLFGVKGSFQGNSVSFSTKEADQRGQLYTISAGFRDYGGYNDSLQDYVQLLRQ
                     GIDGNQDFYKPAWRSEAKNYLQATRFLTGKYATDKQYDNKLNSLIAVYNLTQFDLPKTV
                     DGLIIQSKNKLSEAEQQQMHFPVYDGINYNRSGSYPVGQCTWYVYNRFKQLGTSVDEFM
                     GNGSDWGRKGRALGYQVSSLPKAGRAISFQPGVAGADNQYGHVAFVEAVTSDGIIISES
                     NVINDQTISYRVLPNVIAYSSGVTYIGA"
     misc_feature    complement(9054..9069)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            9181..9912
                     /gene="fsrA"
                     /locus_tag="PO880_RS06730"
                     /old_locus_tag="PO880_06730"
     CDS             9181..9912
                     /codon_start=1
                     /gene="fsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109506.1"
                     /locus_tag="PO880_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06730"
                     /product="response regulator FsrA"
                     /protein_id="WP_073340375.1"
                     /transl_table=11
                     /translation="MAIYILEDQIIQAKALEALVTNILHSRNIYNETIHLFSRSDELLQ
                     VAHQDAQLNIFFLDIQMNNHIQAGFEVAKEIRKTDSESLIVFISTHTELVLTSYKYMVS
                     ALQFIQKNVDFLDFQKEVETCVDAYIQQKENIKTKSEYIIINLKASSIKMDINDIYFFQ
                     TEYDHRVSMVGKNFKREFYGTLSKIEQLHPDLIRVHQSIIINKKYASKLNYKTHLLTMR
                     DGTEVPVSRRYYTQVKALFLT"
     gene            10001..10729
                     /locus_tag="PO880_RS06735"
                     /old_locus_tag="PO880_06735"
     CDS             10001..10729
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016634271.1"
                     /locus_tag="PO880_RS06735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06735"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_002377181.1"
                     /sec_met_domain="AgrB (E-value: 1.2e-31, bitscore: 106.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIDWILKNIMDMDQEDQSGKTQWTKYYLTVYFSGLFNFLMILIL
                     SVLFGTLSETFIVYVVLIFLRPVAGGWHAKTKWLCRLESIVIYVAIPFVLKNSSVSLPF
                     IYKILLICLLVVLFYWYAPQGTAIEPVQPSDLNVLKKQSLIRVCLLILCSLFVKEKIAS
                     VILYGLVIQGLMILPVTKNLIEGSVFMKFGKKIIKNVIEKRVAKVSDGVGTKPRLNQNS
                     PNIFGQWMGQTEKPKKNIEK"
     gene            10726..12069
                     /gene="fsrC"
                     /locus_tag="PO880_RS06740"
                     /old_locus_tag="PO880_06740"
     CDS             10726..12069
                     /codon_start=1
                     /gene="fsrC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402207.1"
                     /locus_tag="PO880_RS06740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06740"
                     /product="sensor histidine kinase FsrC"
                     /protein_id="WP_010710273.1"
                     /transl_table=11
                     /translation="MILSLLATNVLLVSSFIVFVFLRVTLIKIECKIPLLSLLIVINLC
                     SFAALMLGCSWLIYALTVVIFTGFLLIHKKRFSIFKAIFLSVFTLLMVSFINYTEQTIL
                     SVFFQQIYQNKLLWIASNVILLLINIWIALKIPNSVFLRLNRVLENSRIFFGCLLLLLI
                     LLLLFVFLISPEISPDFMRGFVTVNSSKLELLISVGLFLILIGLVIEAYLEEQRINTQL
                     LNNLTIYTEKIESINEELAMFRHDYKNLLYSLQIAISYEDILEIKRIYEETIAPTKKII
                     DNEEFELMKLNRLKNMELKALISMKINTAKQAKLKVIVDVPEVFILDTSIDLVVVIRLL
                     AILLDNAIENSAKSELKMFAISIFNKNETQEFVITNSVQAEFDFKVMKKTKFSSKSNPE
                     EHGWGLLYVKEIVDFSDQFDLQTSFNEGSVTQHLIIEKNHNSKKVVNE"
     gene            12304..13836
                     /gene="gelE"
                     /locus_tag="PO880_RS06745"
                     /old_locus_tag="PO880_06745"
     CDS             12304..13836
                     /EC_number="3.4.24.30"
                     /codon_start=1
                     /gene="gelE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002369251.1"
                     /locus_tag="PO880_RS06745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06745"
                     /product="M4 family metallopeptidase coccolysin"
                     /protein_id="WP_104680765.1"
                     /transl_table=11
                     /translation="MMKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLS
                     KLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDKNGAVTSV
                     TGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDLVFLAIDKRVNNEGQLFYKVRVTS
                     SPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVTFNVPVEKSNTGIALHG
                     TDNTGVYHAVVDGKNNYSIIQAPSLVALNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRG
                     MPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAG
                     LEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMA
                     QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQ
                     FSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVNQPSESVLVNE"
     gene            13885..14739
                     /gene="sprE"
                     /locus_tag="PO880_RS06750"
                     /old_locus_tag="PO880_06750"
     CDS             13885..14739
                     /codon_start=1
                     /gene="sprE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002364098.1"
                     /locus_tag="PO880_RS06750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06750"
                     /product="serine proteinase SprE"
                     /protein_id="WP_002364098.1"
                     /transl_table=11
                     /translation="MKKFSIRKISAGFLFLILVTLIAGFSLSANAEEYIVPAESHSRQK
                     RSLLDPEDRRQEVADTTEAPFASIGRIISPASKPGYISLGTGFVVGTNTIVTNNHVAES
                     FKNAKVLNPNAKDDAWFYPGRDGSATPFGKFKVIDVAFSPNADIAVVTVGKQNDRPDGP
                     ELGEILTPFVLKKFESSDTHVTISGYPGEKNHTQWSHENDLFTSNFTDLENPLLFYDID
                     TTGGQSGSPIYNAQFEVVGVHSNGGIKQTGNHGQRLNEVNYNFIVNRVNEEENKRLSAV
                     PAA"
     gene            complement(14887..15717)
                     /locus_tag="PO880_RS06755"
                     /old_locus_tag="PO880_06755"
     CDS             complement(14887..15717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002397393.1"
                     /locus_tag="PO880_RS06755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06755"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_272731683.1"
                     /transl_table=11
                     /translation="MKINYLGTGAAERIPGIFCNCKLCKYAREKKGREIRTQTQLIIDD
                     VLLIDFPGDSYLHLLQYDLCFADFDSLLISHWHSDHFYGEDLAYRMSGYALDIPNRLTV
                     YGNEAVKTFYQRAFDLEGRQDDTRLHYQVIQPYKCFTIANYTIYPLPAQHGNFSEDCFI
                     FVIDDGKDAFLSTHDTGYFTSEMFEYLEKNHLLLSIVSLDCTSQTNETGNSHMNWEENL
                     KLIAELKERKLVTDKTIYVANHFSHNGGLSYAEMAALSQKHEIITSYDGLEILT"
     gene            16109..16963
                     /locus_tag="PO880_RS06760"
                     /old_locus_tag="PO880_06760"
     CDS             16109..16963
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010821679.1"
                     /locus_tag="PO880_RS06760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06760"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_002361978.1"
                     /transl_table=11
                     /translation="MTIEKLEYFYTIAKYNSISKAASELHVSKSTLSASLKDLESELGH
                     LLFDRNGNSLTLNSYGDKIVQSVYIILNEAKKMKLNLHEMIENPVMRLGFGNTSLMYKV
                     TENEDQLNRFWECYHGSSFELLNKLENHELDFVITSADVNSPVLKKEQLIELKMYLCVS
                     REIKQEIEEEGFSCLTNYPFLFLPHHLDHLEATKSVLEMLQLTSPLVCCYDTLMLTRLI
                     EKSKGVYAVISLRKEQLQEIDSKLFFLPIERKQKFYLYRNVSSSVFVQPGQIKATLQKL
                     LET"
     misc_feature    17067..17083
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            17345..18733
                     /locus_tag="PO880_RS06765"
                     /old_locus_tag="PO880_06765"
     CDS             17345..18733
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010712556.1"
                     /locus_tag="PO880_RS06765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_06765"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_002391405.1"
                     /transl_table=11
                     /translation="MIDRKKVILYTCCMSLFVVTMDVTVVNVALPSIQSDFHTNLSTLQ
                     WVTDGYTLMVASLLLLSGSTADRIGRKRVLQLGLACFGLASFLCGISQTPGQLIAFRML
                     QGIGGSMLNPVAMSIITQVFTEKLERAKAIGLWGSVTGISLGMGPIIGGLIVSYFSWRY
                     VFFVNVPIIAAAIILTQKFVPESKVEKTAKNDFVGQALMILFLFSSIYSIIGLPRKGLF
                     APDILSTGIIGCLAIVIFFIYEYNIDNPLINPRFFLSIPFTSASFLAIFGFIIYNGYLF
                     LNTLYLQEMRGFSPLEAGLSTIPLAFVSFLVAPRAGEMVGRIGTKRPIMLCGISMLAVS
                     FLQLFVTKTTPMIILFIIYIFLGIGFGMLNSPITITAIEGMPLSQSGTAAAIAVTCKQI
                     GNSLGVALPSLLITKPITSSLTRTPFTNVWLLFGCCAIAIIFLSYLSNSPLAKKSLRRV
                     RFYF"
     misc_feature    complement(20138..20152)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(20608..20623)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: strong, score: 28.99"
                     /tool="antismash"
ORIGIN
        1 aggaaaagtt gttcctgttt gtcaaacacg tcaaccagaa gaaattaatg ctatttttga
       61 agaaatggaa caaggaaaaa ttcgcgggcg catggtcatt gattttcgca tttaatttgt
      121 ttttttagtg attcgttgat ttaatctgaa taccatgaaa ggatggatgg aatgtttgcg
      181 aatcttactc tccgtgagag acgactgctt aaacaagcac aattgggagc cacaattagc
      241 tttattcttt tgtttgtacc aattctgaca atcagtcttt tgcatactag tgacttatta
      301 gcaaaatggc taggtatagt tggggtaatt atggttttac cattgttgta ttttgcgtgg
      361 cagattttaa agatagccta taaagatcaa aaagataatc caacgcctcc tttgtgggtt
      421 ccgaaagttt atggaattgg gctttcgatc aatccctatc atcggtttgg aaagttaatt
      481 tttatattgc tagcggtact gatagttggc atcatcatta gtttgctttt cacaccagca
      541 agtcaaatca atcactaaaa aacgagtaat caacaccctc ttgccgagca ggagggtgtt
      601 gattattttt aaatagacta aatttgagta acaggtatta gatttttgaa aaagtctttc
      661 tttttctgat gtagatattt tcgcaataaa atcatcattt taagtgaatt aacaggttta
      721 tcaagggtta atacttgtta atggtggctg ctataattaa ccgttgacaa acacaaaaaa
      781 accatcatac gataattatg ttattaaaaa agtgaaaaat tggtagtcaa caaatgaaaa
      841 cgcattcatt gggaaattgt gattctgtac taaaattttt atataagatg aaaatggatt
      901 gttttcattt aatattttat tgaaaggatg tgtttatgaa ggggttactg aaactgactt
      961 gcttacagtc tcagtaaact aagaaaatcg ttatgacttt tcatctggat aaaactttgt
     1021 tgggttttgg attttgtgag taattgtgtc ggaactattc tatggggagc aattttaagg
     1081 aggaaaaaat gaacaaagag tatcagggta aaaaaattta cggtaaaaag cactggttga
     1141 catttttatt agtgagttcg tctgtattgg cgttccattc gtttgttacg atggattctc
     1201 aagtggttga tgcgcaagag caaacagcaa aagaagacgt agctgattca gcaacgtcag
     1261 tcggagcaat tgtgtcgatt gaaaaagcgg agaaaaactt tgtcattacg tatgcttctg
     1321 gaaaaaaagc acaaattagt attttaaacg accatctttt tcgctatcat ctagatccaa
     1381 ctggtaaatt tgaagaatat ccaacgccaa atgatccaaa gcatgttgcg aaaattacgg
     1441 ctaaaacaat ggccgactat ggcacacaag cctttgagca aacgaacgtc acagattcag
     1501 gaaaccaatt tattctagaa aataatggtt taaaaattat attcgaaaaa gaaagcgctt
     1561 taatgaaggt tctagacaag aaaaagaatc aagttatttt agaagaaacc gctccgctat
     1621 cctttaaaaa tgataaagct acacaaacgt taaaacaaag tagtcaagaa aattattttg
     1681 gcggaggaac tcaaaatggt cgatttacgc ataaaggaac agctatccag attgtcaata
     1741 cgaacaattg ggtagatggc ggagtagcat cgcctaaccc attttattgg tcaactgcag
     1801 ggtatggcgt tgttcgaaat acatggaaac ctggcaacta tgattttgga agtcatgatc
     1861 cacaaacaac cacaacaacg cacgaaggaa cagattttga tgctttttat ttctttaatg
     1921 attcctcagc aggtatttta aaagattact atgaattaac cgggaaacca gctttgatgc
     1981 cagaatacgg gttctatgaa gcacatttaa acgcgtataa tcgggactat tgggtgaaag
     2041 tagcagaagg aaccgcggga gcagttaagt ttgaagatgg taatttttac aaagaatacc
     2101 aaccaggcga tctaggaaac ttaaatggca cgctagaatc tttaaatgga gaaaaagaga
     2161 attatcaatt ttctgcacgc gcagttattg atcgatataa gaaaaacgat atgccgttag
     2221 ggtggttctt gccaaatgac ggctacggtg ctggctatgg ccaaacagat tcattggacg
     2281 gcgatgtaca aaacttaaaa ggatttacag agtatgctca agccaatggt gttgaagtgg
     2341 ggctgtggac tcaatctaat ctccatccag cggatcctaa aaatcctaaa aaaggagaac
     2401 gggatattgc gaaagaagtt agtgtcgctg gtgttaaagc tctcaaaact gacgtggcgt
     2461 gggtcgggta tgggtattcc tttggcttaa atggtgtaga agatgccgcg aatgtttttg
     2521 taaaagaaac agacggcgca gttcgtccga tgattgtttc attagatggt tgggccggaa
     2581 cccaacggca cgctggtatt tggacaggcg atcaaacggg tggtcaatgg gaatatattc
     2641 gcttccatat cccaacatat atcgggactt cgttgtctgg acaaccaaat gtcggttcag
     2701 atatggatgg aatttttggt ggaaaaaata aagaggtcaa catacgtgat ttccaatgga
     2761 aaacttttac accagtgcag ctaaatatgg acggctgggg ctccaatcca aaaacgccat
     2821 ttgcttttga tcaagaagcc acagatttga accgagcgta tctaaaatta aaatcaatga
     2881 tgatgcctta taactacagt attgccaagg aatcagttga tggactacca atggtacggg
     2941 ccatggcttt agaatttcct aatgaaggaa cagcatatac aaaagattct caataccaat
     3001 atatgtgggg acccaattta ctcgttgccc caatttataa tggcaatcaa gatgaggcag
     3061 gaaattcaat ccgtgatgga atctacttac cagatgaaaa acaagtctgg gttgacttat
     3121 ttacaggcga aaaatatcaa ggtggccgtg tcttaaatgg agtaaaaaca ccgctgtgga
     3181 aggtgcccgt tttcgtcaaa gatggcagta ttatcccaat gacgaatcca aacaacaatc
     3241 caaaggaaat ccaacgagat caacgatctt tcttgattta tccaaatggc accacttctt
     3301 ttaatatgta tgaagatgac ggaatttcaa ctagttatga agctgggcaa tcagctacga
     3361 ctaaaataaa tagtcaaggc cctaaatcaa acgaaaaagg ggatctgacc gttactatcg
     3421 aaccgacaaa aggaagttat aaaggctttg ttgatgaacg aagcaccacg cttgatttgt
     3481 tagcttcaga agcgcccgaa agcgtaacag caatggtggg gggaacagaa gtaaccttga
     3541 aacaagcagc taataaagaa gaatttttag ctggcacaaa tctatattat tttgataaag
     3601 aattccaagt gaatcagtat ctttctgaag cttcaggaga aaaactgaac caatcagcgt
     3661 tatcagtaaa actagcgaaa caatctgtga ccgccaaaga tgttcaaata actgtcaaag
     3721 gtttcattaa taaaggaacg gttgacggag gaaatacaac ggtcgatgac cagttaacta
     3781 ttccggcaaa tgtcgcaatc aatgaagaaa aaacaacgcc atcttctttg actcttcaat
     3841 gggatcaagt aactgaggca acaagctatg aagtagagcg tgacggaact gttttcggaa
     3901 atattcaaac gaatacagca acatttgatg gattttcctt cctaagcgaa catacttttc
     3961 gagttcgagc tgttggaaaa aacggggtct ctgaatggag tgaaccgatt aaaggaaaaa
     4021 cacaagatga tccctataaa gaaacaatta atcaagtcaa agcaacaagt aatttaccag
     4081 aacaaccagg cgcagaattg aagaaattaa cagataaaga tttgagtaca ggttggcata
     4141 cgaactggtc aaccggcatc gctaatccaa gtgatggaaa tttcttgtct ttaaaatttg
     4201 atcttggtgc ggagtatcaa atggataaaa ttgaatactt gccaagagac aatgccggca
     4261 acggaaatat tttgcaactc cagtatcgga cgtcgaaaga tggagctaat tggacagagt
     4321 tttcagaacc tattaactgg aagcaagatg ctttgacaaa aaccattgaa acgaaggagc
     4381 aagcgtatcg ttttgttgaa atgaaggtat taaaatcggt gggtaatttt ggctctggtc
     4441 gtgagatgct cttttacaaa caaccaggaa cagaaggaat cttacatgga gacattacta
     4501 atgatggaac gattgatgaa aatgatgcaa tgagttatcg aaactataca ggcttagaat
     4561 ctgtggacag tgactttaat ggctatgttg aaaaaggcga tttaaataaa aatggggtaa
     4621 ttgatgctta tgatatcagt tatgttttac gacaattaga tggtgggatt gagatacctg
     4681 atgtcgaaga aattgcgggc ggtttatccc ttgctgtggt taatgaaaat ggcaaggata
     4741 cctatcttcc tggcgataca ttaaccttta cacttaaagg tcaagactta aaaaacatta
     4801 atgcgttaag cacaaaaatg tcctttgatt ctagcaaatt tgaacttgtc ggtcagcctg
     4861 caaccacgaa taatacaaaa caaatggaaa attattctaa atatcggaaa cattcaaatg
     4921 atgtggagaa tctgtattta gttcttagta atcaaggaaa taaacaattg ttaaatggtt
     4981 caatggactt agttaccttt aaagttaaag taaaagaaac aactcgcgta aaacgtgcga
     5041 caactgttga gcagccatta caatttgata tgagtcaagg cttattagta ggccaaggat
     5101 tccaacaagc cacactttca gatttttctg taacagtgaa gcccacagag ctagtagata
     5161 aagagttatt acaagcgcta attacgctaa atcaagcacg tgtcgaaaaa gaatatacgc
     5221 ctgaaacttg ggcaattttt aaaccagtct tagatgaggc agtagctgtt ctagccaatg
     5281 aacaagccac acagacagac gtttctgctg ctgtggaaaa cctagaaaag gctgcaagtc
     5341 agttggaaaa aatgcctgat gtagcgaata aagctgattt agaaaaagca attcaagagg
     5401 ggctggcgaa gaaaccaagt gatgggcaag aattcaccga agaaactaaa aaagttctcg
     5461 aagactcatt agcagcagct caaaaagtat ttgctcaaga aaaagttacc caagaagaaa
     5521 tagaccaagc gactaaaaca ttgcgtgaag caattgcaca attaaaagaa caacccgtcg
     5581 ccgttgataa ggaaacctta aaagagaaaa tcgctcaagc tcgaggaaga aagccggaag
     5641 aaggatacca atttacaaaa gaaacagaaa aacaattgca agaagcaatt caagcggctg
     5701 aagcaatcgt agcgaaagaa acggcgacaa aagaagaagt ctctgaggct ctaaacgcat
     5761 tggaaactgc aatggctcaa ttaaaagaag taccccttgt aaataaagac caattacaag
     5821 aagtagtcaa acgagcgcag caagtcactc caagtgaagg gcaccaattt actgcctcct
     5881 cgttacaaga tttacaaaaa gcgcttttag cagctaaaaa cacattggaa aacccagcag
     5941 ctaatcaaaa aatgattgat gaagcggttg ctgaattaac tagtgccatc gatgggttac
     6001 aagaagaagc gttagttaca gataaaaaag ccttagaggc aatgatagcc aaagcaaaag
     6061 caatcaaacc atctgccgga aaagaattta ccagcgagtc taaagcgcgc ttaactgaag
     6121 caattgacca agcggaaggg attttagctg ataaaaatgc tcggcaagaa caaattgata
     6181 ctgctgaaaa aaatgtaaaa actgctttgg atagtttaga ggaacaagtc cttcaagcgg
     6241 ataaaacaaa gttgagagaa ctgcttcaaa aagcagaaac cttgaaacct aaagcaggaa
     6301 aacaatttac aaaagcatcg caagaagctt tagctgaagc aattaaacaa gcaaaagcac
     6361 ttgttgagga cccaagtgcg acgcaagaag ctgtggacaa atgtttaagt attttagcac
     6421 aagccattga agcaatggca gaagagccaa tcagtagcaa ctctacaggc aacaatagaa
     6481 atcatggcac ggttagcggg actggtagcg taaccagtcc aggaaagggc acagcagcag
     6541 gtggaacgac aacaaaaacc accacttctg gtactttgcc aaaagcaaat gaagttgttt
     6601 cgccaatctg gtcaatcagt ggttttctat tgatagtaag tattggttta ggaaaattat
     6661 tcttcaaaaa taaaaaagac caaaattagc gtatcattaa cttacaaggc gcatttgtac
     6721 aaaaacagtg tgcaaatgcg caagtaagta ataggagagg atttttacga atgaaaagaa
     6781 agaaaatcaa gaatcaacta cttgttttaa caagtattct cgttcttctg agtttggaag
     6841 tcgctccagt tgttacgttg gctgcagaat taccaagtag ctcgctacaa acagctctgt
     6901 cctcggaaac gacaattact tcggaagaaa aagtaattga aacaaccgaa acaaccgaaa
     6961 caactgaaac aactgttgct acatcgacaa cgtccactag tagttcgtca tctgaatcaa
     7021 atagttctac cgatacgact accgaatcaa cgagtcattc aacgacagaa acgacaacca
     7081 caaatactag ttctgaaaca aaaaaagaac ctacagagcc aacggtatca tcagaaatca
     7141 cgcagcctat tgaacaatcg caaccaccac aagttcaacc accacaagtt cctgtgacca
     7201 agcaagaacc tgaagaacct attcaagttc ctgaagccac caataacgtt gttgaagaaa
     7261 atcaggctgt atcgttaaat ccgtccctca aagtagatga aatagcttct tcaaatttaa
     7321 aaggctacga actgccactg ttgtcgtctt ttggcgaaaa gaaacgggca gtcgtggtgg
     7381 ctgaagcatt aagacacatt gggaaaacaa aaaaagaatt taatttgacg gagcaagcat
     7441 tgaccagtag tttccttgcc caaaaaattt accaacaatt atttaaaata gacattggca
     7501 gtacaccgca agaacaaatg acatttggta aagttcgttc tatagaggag gcagaacctg
     7561 gtgatctgat tttttggcaa acagctgaag gaaaaacgct tcaaaatggt gtttatcttg
     7621 gccaaggaaa atatttaatt gccgcagcgg aagcggattc taaagagaaa ccagaagtaa
     7681 tcgctcagtt agagaatatc tatactgcca aacaacaacc agactcaaaa gaggaaaaac
     7741 gcttggtagt gactaatcct tttaaggagt tcatattaac ggagtatggc aaagaagttt
     7801 tagcaacata tggtgcgtca tttgaaatgc agaagtcaga acaaaccaca gcgtttatta
     7861 aaaaaattgg tgagacagcc agagaacttg gcgaaaaata cgatgttttt gcatcagtga
     7921 tgatagctca ggctatttta gaaagtggct ctggcgaaag tcaactagcc aaagaacctt
     7981 attataatct ctttggcgtg aaaggttcgt tccaaggaaa tagtgttagc ttttcaacaa
     8041 aagaggctga tcagaggggc caactttata caatttccgc tgggtttcgc gattacggtg
     8101 gctataatga ctcactgcaa gattatgttc aattactccg acaagggatt gacggaaatc
     8161 aagattttta taaaccagcg tggcgttcgg aagccaaaaa ctaccttcaa gcaacgcgtt
     8221 ttttaacagg taaatatgca acagacaagc aatacgataa taaattaaat tcgttaattg
     8281 cggtttataa cttaacgcaa tttgatttac caaaaacagt ggacggtttg attatccaat
     8341 ctaaaaataa gctgtcggaa gcggaacagc aacaaatgca ttttccagtc tatgatggga
     8401 tcaattataa tcgaagtggt agctatcccg tgggccagtg tacgtggtat gtctataatc
     8461 gtttcaaaca gttaggcact tctgtggatg aatttatggg aaatggcagt gactggggaa
     8521 gaaaaggacg tgcattaggc tatcaagtta gttcattgcc taaagctggt cgtgcgatta
     8581 gtttccaacc aggagttgct ggcgcagata atcaatatgg acatgttgct tttgttgaag
     8641 cggtcacttc tgatggaatc attatttctg aaagcaatgt catcaatgat caaacgattt
     8701 cgtatcgtgt cttacctaat gtaattgctt atagtagtgg cgtgacctac attggcgctt
     8761 aatcgactca ttcaacagga agaagtgtgg atgtttaagt aaaaaattag cacaatgatc
     8821 catgtgtgaa ctaacaaatt aaaataacca gaatcgacca atgaattgat tttgtcatgt
     8881 ataaaatgac aagaacagtt tggtggttga ttctttgttt ttcatcaacg aagagacaat
     8941 agtcctcatg attcgttaga aaaagatgaa tagtccaaag tactctttct tgatgctttg
     9001 ttattttatg tttttgtttg caggaaacta ctgaaatcgc tatactaaat ttatgtgaat
     9061 atactaacag acaatcaatt ttttatctct tttattggtg tataaattga ttgaacatta
     9121 taatcatttg tcttttgttg tgtaatttta tatcttcttg agaaagggat gagtgaacaa
     9181 atggctattt atatattaga agaccaaatt attcaagcaa aagcgttaga agcattggta
     9241 acaaatatcc tacattcaag aaatatttat aatgaaacaa tccatttatt ttcacgttca
     9301 gatgaattat tacaagtggc acaccaggac gcccaactaa atatcttttt cctagatatt
     9361 caaatgaaca atcatatcca ggcaggattt gaggttgcta aagaaatcag aaaaacagac
     9421 agtgaaagtc tgattgtatt tatttctact cacacagaat tagttttaac ttcctacaaa
     9481 tatatggttt cagctcttca atttattcaa aagaacgtgg attttctaga tttccaaaaa
     9541 gaggtcgaaa catgtgtcga tgcatatatt caacaaaaag aaaatataaa gacaaaaagt
     9601 gaatatatta tcattaactt aaaagcgtct tctataaaaa tggatattaa tgatatttat
     9661 ttctttcaaa cggaatacga tcatcgtgtg tcaatggttg gtaaaaattt taaaagagaa
     9721 ttttatggaa cgttatcaaa aattgaacaa ctgcatccag atttgattag agtccatcaa
     9781 tcaatcatca tcaataaaaa atatgcgtca aaattaaatt ataaaacgca tcttttaact
     9841 atgagagacg gaacggaagt accagtctca agaagatatt atactcaggt caaggcacta
     9901 tttcttactt agggagggat aatgactaat taaggaatta tctatctatt agtcgctata
     9961 ttcgttataa tttagtgcaa tacttgaaga ggagggcgat atgctaatcg attggattct
    10021 aaaaaatatt atggatatgg atcaggaaga tcaatcagga aaaacacaat ggacaaagta
    10081 ttatctaacc gtttattttt ctggcttatt taattttctg atgattctga ttttatcagt
    10141 tttatttggg acgttaagcg aaacctttat tgtatacgtc gtactgattt ttttacggcc
    10201 tgtcgcaggt ggctggcatg caaaaactaa atggctctgt cgtctagaaa gtattgttat
    10261 ctatgttgcc ataccatttg tattgaaaaa ttcttctgtg agcttaccgt ttatttataa
    10321 aattttattg atttgcctct tagtcgtatt attttattgg tatgcgccac aaggaacagc
    10381 aatcgaacct gttcagccat ctgatttaaa cgtgctcaaa aagcaaagcc ttataagggt
    10441 gtgtttactt attttatgta gtctgtttgt caaagaaaag attgcttcag taatactcta
    10501 cggtctcgtc atccaaggtc tgatgatact ccctgtaaca aaaaatttaa ttgaaggaag
    10561 tgtttttatg aaatttggta aaaaaataat taaaaatgtt attgaaaaaa gagttgcaaa
    10621 agttagtgat ggtgtgggaa ctaagcctag attaaatcaa aattcgccca atatatttgg
    10681 acaatggatg ggacaaactg aaaaacctaa aaagaatatt gaaaaatgat tttgtcgtta
    10741 ttagctacta acgttttgct tgtatctagc tttatcgttt ttgtcttttt acgagtaaca
    10801 ttgatcaaga ttgaatgtaa aataccgtta ctttcattgc ttattgtcat taatctttgt
    10861 tcgtttgcgg cattaatgtt gggttgctct tggttgattt atgcgctgac agtcgttatt
    10921 tttacaggat ttttactcat tcacaaaaag aggttctcaa tttttaaagc gatatttttg
    10981 tctgttttta cattgcttat ggtttcgttt atcaattaca cggagcaaac gattttaagt
    11041 gttttttttc aacagattta tcaaaataaa ttattatgga ttgcctcaaa tgttattctg
    11101 ttgcttataa atatctggat tgctttaaaa attcccaata gtgttttttt aagattaaat
    11161 cgtgtgttag aaaatagccg aatttttttt ggttgtttac ttttattgtt gattctgttg
    11221 ttactttttg tgtttttgat ttcgccagag atttcacctg actttatgcg aggatttgtc
    11281 acggtaaata gttctaaatt ggagttatta ataagtgtag gtttattttt aattctgatt
    11341 ggcttagtca ttgaagctta tttggaagaa caacgtatca acactcaatt attgaataat
    11401 ttaacgattt atactgaaaa aatagaatcc attaacgaag agctagcgat gtttcgtcat
    11461 gattataaaa atttattgta tagtttacaa attgctattt catacgaaga tattctggaa
    11521 atcaaaagaa tttatgaaga aacgattgca ccaaccaaaa aaattattga taatgaagaa
    11581 tttgaactta tgaagttaaa tcgtttgaaa aatatggaac ttaaggcact cataagtatg
    11641 aaaattaata ccgcaaagca agcaaaacta aaagtgattg ttgatgtgcc agaagtattt
    11701 attcttgata catcaatcga cttagtggtt gtgattcgtt tgttggctat tctattagat
    11761 aacgcgattg aaaacagtgc aaaatcagaa ttgaaaatgt tcgctatctc aattttcaat
    11821 aaaaatgaaa cacaagagtt tgtgataaca aatagtgtcc aagccgaatt tgattttaag
    11881 gttatgaaga aaaccaaatt tagttctaaa agtaacccag aagagcacgg ttggggattg
    11941 ttatatgtaa aagaaattgt tgatttttca gatcaatttg atttgcaaac gtccttcaat
    12001 gaaggatcgg ttactcaaca tttaattatt gaaaaaaatc ataatagtaa aaaagttgtt
    12061 aacgaatgaa tttgttaaca acttttttgc tatggtattg agttatgagg ggcaatacag
    12121 ggaaaaatgt cggctgatta aggaatttag atagtgccgg ttaggtagtt gtctataatg
    12181 aaaatagcaa caaatattta cgcagggaaa ggggcggtcg tttaacggga aagattaggg
    12241 aggataaagt aatacttttg ttgggaaaag aaataaaagg aaactgggga aggagttaat
    12301 tgtttgatga agggaaataa aattttatac attttaggta caggcatctt tgttggaagt
    12361 tcatgtctat tttcttcact ttttgtagcc gcagaagaac aagtttattc agaaagtgaa
    12421 gtttcaacag ttttatcgaa gttggaaaag gaggcaattt ctgaggcagc tgctgaacaa
    12481 tatacggttg tagatcgaaa agaagatgcg tgggggatga agcatcttaa gttagaaaag
    12541 caaacggaag gcgttactgt tgattcagat aatgtgatta ttcatttaga taaaaacggt
    12601 gcagtaacaa gtgttacagg aaatccagtt gatcaagttg tgaaaattca atcggttgat
    12661 gcaatcggtg aagaaggagt taaaaaaatt attgcttctg ataatccaga aactaaagat
    12721 cttgtctttt tagctattga caaacgtgta aataatgaag ggcaattatt ttataaagtc
    12781 agagtaactt cttcgccaac tggtgacccc gtatcattgg tttataaagt aaatgctaca
    12841 gatggaacaa ttatggaaaa acaagattta acggaacatg tcggtagtga agtaacgtta
    12901 aaaaactctt ttcaagtaac gtttaatgta ccagttgaaa aaagcaatac gggaattgct
    12961 ttacacggaa cggataacac aggggtttac catgcagtag ttgatggcaa aaataattat
    13021 tctattattc aagcaccatc actagtagca ttaaatcaga atgctgttga tgcctatacg
    13081 catggaaaat ttgtgaaaac atattatgaa gatcatttcc aacgacacag tattgatgat
    13141 cgagggatgc ccatcttgtc agttgttgat gaacaacatc cagatgctta tgacaatgct
    13201 ttttgggatg gaaaagcaat gcgttatggt gaaacaagta caccaacagg aaaaacgtat
    13261 gcttcctctt tagatgtagt tggtcatgaa atgacacatg gtgtgacgga acatactgcc
    13321 ggtttagaat atttaggaca atcaggtgcg ttgaatgaat cttattctga tttgatgggt
    13381 tatattattt cgggtgcatc taatccagaa attggtgcgg atactcagag tgttgaccga
    13441 aaaacaggta ttagaaattt acaaacgcca agtaaacacg gacaaccaga aaccatggct
    13501 caatacgacg atcgagcacg gtataaagga acgccttatt atgatcaagg cggtgttcat
    13561 tataacagtg gaattattaa tcggattggt tacaccatta tccagaactt aggcattgaa
    13621 aaagcacaga ctattttcta cagctcatta gtaaattact taacacctaa agcacaattc
    13681 agtgatgctc gtgatgcgat gcttgctgct gcaaaagttc aatatggcga tgaagcagct
    13741 tcagtggtgt cagcagcctt taactctgct ggaatcggag ctaaagagga tattcaagta
    13801 aatcaaccaa gtgaatctgt tctggtcaat gaatgaaaaa aattccccaa ttaaataaaa
    13861 atggataagg agtggcataa tcttatgaaa aagttctcca tacgaaaaat tagtgctggt
    13921 tttttgtttc tgattttagt aactttgatc gccggtttta gcttgtctgc aaatgcagaa
    13981 gagtatatcg ttcctgccga aagtcattca cgacaaaaaa gatcgttact ggaccctgaa
    14041 gacagaagac aagaagtggc agatacaacc gaagcgcctt ttgcgtcaat cggaagaatc
    14101 atttcccctg ccagtaaacc aggctatatt tctttaggaa caggctttgt tgttggaacc
    14161 aatacaattg tcaccaataa tcatgtggct gaaagtttta agaatgccaa agtattaaat
    14221 ccgaatgcta aagatgatgc ttggttttat ccaggtcgag atggcagtgc gacaccattt
    14281 ggcaaattca aagtgattga tgtagctttt tccccgaatg cggatattgc ggtagtgact
    14341 gtcggcaaac aaaacgatcg tccagatggc ccagagttgg gagaaatttt aacgccattt
    14401 gttttgaaaa agtttgaatc ttcagatacc catgtaacaa tatcaggcta tccaggtgag
    14461 aaaaaccaca cacaatggtc tcatgaaaat gatttgttta catctaactt tacagactta
    14521 gaaaatccat tactatttta tgatatcgat acaacaggtg gtcaatctgg ttcaccaatc
    14581 tataatgctc agtttgaagt agttggtgtt cattccaatg gcggcattaa gcaaacagga
    14641 aaccatggtc aaagactaaa tgaagtgaat tataacttta ttgtcaatcg agtgaatgaa
    14701 gaagaaaata aacgtttatc cgctgtgcca gcagcgtaaa gaaccataaa aatactcgga
    14761 atttccagaa tcacgggaaa tctcgagtat ttttgttttt taagatagtg taagttacga
    14821 taaaagtacc ttgtaattat cggttaaaag catataatag tgctgaaaag aaggcaaata
    14881 atccgattaa gttagtattt ctaaaccatc ataactcgta atgatttcat gcttttgaga
    14941 taaagccgcc atctccgcat aagacaagcc gccattgtga gaaaaatggt tggcaacgta
    15001 aatcgtttta tctgtgacga gttttctttc ttttaattct gcaattaatt ttaaattttc
    15061 ttcccaattc atatgactat tgccagtttc gtttgtttga ctagtacaat ctaaagaaac
    15121 aatactaaga agtaagtggt tcttttcaag atattcaaac atttctgacg taaagtaacc
    15181 tgtatcatgg gtggataaaa aagcatcttt accatcgtca ataacgaaaa taaaacaatc
    15241 ttcactgaaa tttccatgtt gtgcaggaag gggataaatc gtatagttcg caatagtaaa
    15301 acatttgtag ggctgaataa cctgataatg taatcgggta tcgtcttgac gaccttctaa
    15361 atcaaaggcg cgctgataaa acgtcttaac tgcttcattt ccgtaaacag ttaaacgatt
    15421 gggaatatct aatgcataac cagacattcg ataagccaaa tcctcgccgt aaaaatgatc
    15481 ggaatgccaa tgagagatta gtaaagagtc aaagtctgca aaacacaagt catactgcaa
    15541 caagtgtaaa taagaatccc ctggaaaatc aatcagcagg acatcatcaa taattaattg
    15601 agtttgtgta cgaatttctc gtcctttttt ctctcgagcg tacttacata atttacaatt
    15661 acaaaaaatt cctggaatcc gttctgctgc acccgtacct aaatagttga ttttcattgg
    15721 gagtacctaa cctttctttg acattcttca tacttagtag ataacgctga accttaaagt
    15781 aaatgggcat ggaaactgaa acatttgttg tgtccatctt acctttttta gagaagaatt
    15841 gaaatggaat ttcttaagta aatatgcgta aaatagaaaa agctagacgc cttttttgat
    15901 aagctgaatt tactgcgaat gctcgtacta tttccgaaaa aaagttttac caaaggcact
    15961 ttcatatcca tctgctatta gttatagaaa aataacaaga tggacatagc ttattagagc
    16021 aaaaataact acgctattga taaagagtga ggcgtgtttt gaacaggttg cgtgggcaaa
    16081 tgaatttgaa taaaagggat gacaaaagat gactattgaa aaattagaat atttttatac
    16141 cattgcaaaa tataatagta tttccaaagc agcctctgaa ctccatgtta gtaaatcaac
    16201 cttaagtgcg tcattaaaag atttggaaag tgaattgggc catttacttt ttgaccgtaa
    16261 cgggaattct ttgacgttaa attcctatgg tgataaaatc gtccaatctg tatatatcat
    16321 tttaaacgag gccaagaaaa tgaaacttaa tttgcatgaa atgattgaga atccagtgat
    16381 gcgtttaggt tttggaaata cgtccttgat gtataaagtg acagaaaatg aggatcaact
    16441 gaatcgtttt tgggaatgtt accatggttc atcgtttgag ttattgaata aattggagaa
    16501 tcatgagttg gattttgtga ttacttctgc agatgtgaat agtccagttt taaagaaaga
    16561 acaattaatt gaactaaaaa tgtatctttg tgtttcaaga gaaattaaac aagaaattga
    16621 ggaagaaggc ttcagctgtt tgaccaacta tccatttcta tttttgcctc atcacttaga
    16681 tcatttagaa gctaccaaga gtgtgctaga aatgttgcaa ttaacaagtc cgcttgtttg
    16741 ttgctacgat acattgatgc ttactcgtct cattgaaaaa agtaaaggag tttatgcggt
    16801 aatctctctt cggaaagaac aactgcagga aattgattct aaactcttct ttttaccgat
    16861 tgaacgaaaa caaaaatttt atttataccg aaatgtttcc agttcggttt ttgtccaacc
    16921 tggtcaaatc aaggcaactt tacaaaagtt gctagagact tagccattaa aattactttg
    16981 gaatagttac caaaaatagc tttattcgct tagatttact tttgctgcgg ataaggctat
    17041 ttttgttgtt cattgtttaa aagagatgct caattatggg gctgttcgat atttctgaac
    17101 agaatgttca attatttaat aacttaagaa tcgataaatc gtatctatta cggttcaatt
    17161 taaaggggtt ctggtgtata gtttggctat ctaaagattt atttttttaa gtataaaata
    17221 actaaatggc aaggaatata aagaactgtt gatacgtgag tacttgcgat aactgtgtcg
    17281 ttagaagttt aagtgtcatt gttgcttttc ctgttttatg tagttgctag aaaggactgt
    17341 ttttatgatc gatagaaaaa aagttatttt gtatacttgt tgcatgagtt tgtttgtagt
    17401 gaccatggat gttacggttg tcaatgtggc gttaccatcc attcaaagtg attttcacac
    17461 gaatctgtct acattacagt gggtaacaga tggctacact ttaatggtag catccttatt
    17521 attgttatct gggtctacag cagaccgaat tggccgtaaa cgagtccttc aattgggctt
    17581 agcctgtttt ggtttagcgt ctttcctatg tgggatttcg caaaccccag ggcaattgat
    17641 tgcgtttcgc atgttgcaag ggattggtgg ttctatgtta aatccggtag caatgtctat
    17701 tattacacag gtatttaccg aaaagttaga acgagcgaaa gcaattggct tgtggggctc
    17761 tgttacaggg atttccttag gcatgggccc aattattggc ggactgattg tttcttattt
    17821 tagctggcgg tatgtctttt ttgtaaatgt accgatcatt gctgcggcaa tcatccttac
    17881 acaaaagttt gtacctgagt caaaagtaga gaaaacggcg aaaaatgatt ttgttggtca
    17941 agcattgatg attctttttc tatttagttc tatctattcc attatcggac tacctagaaa
    18001 agggcttttc gcgccagata ttttaagtac tgggataatc ggctgtttag ccattgtcat
    18061 tttctttatt tatgaatata acattgacaa tccgttaatc aacccgcgtt tctttttatc
    18121 tattccattt acatcggctt cttttttagc tatttttggc tttatcatat ataacggcta
    18181 tttattttta aacacgctat atttgcaaga gatgagaggc ttcagcccgt tggaagctgg
    18241 cttatcaacc attcctttgg cttttgttag ttttcttgtt gcaccgagag ccggcgaaat
    18301 ggtagggaga atagggacga aacgtcctat tatgctttgt ggtatttcaa tgttggctgt
    18361 tagcttttta caattatttg taactaaaac aacgcctatg attattttat ttattattta
    18421 tatcttttta ggcattgggt ttgggatgtt aaattcaccg attaccatta cagcgattga
    18481 aggaatgcca ctttctcagt caggaactgc agcagccatt gcggtgacat gtaagcaaat
    18541 tggcaattct ttaggggtgg cgctaccaag tcttttaatt acaaagccta ttactagttc
    18601 gcttactcga acacctttta caaacgtatg gcttttattt ggatgttgcg ccattgcgat
    18661 tatcttttta agttatttat ccaattctcc gctagcgaaa aagtcattgc gcagagttag
    18721 gttttatttt taacaaatca agattttttt gaagggaaag gaagacaaac ttagatgaaa
    18781 aaaataaata accgattagg actcttttta ttttttgttt tactcttttg ggcaaaaacg
    18841 attctggcgt attacctaga tttctcattg ggcgttaagg gcagtctcca acgagaaatt
    18901 ttatggttca atccagttgc tactacgctg ttattatttg gttttagttt gtattttaaa
    18961 aagcataaaa catttatgct tagcttaact cttttaaatg ttttaaatac attaatttta
    19021 tatttgaata ttatttttta tcgtgaattc actgacttta ttaccatcca atctgttttt
    19081 ggcttttcaa aagtttcaga agggatttct ggtgatttac ttgctttaat gagagtccac
    19141 gatgtctttt attggctaga tactttagtg ctgctcgttt tggtatttta ctcttttaaa
    19201 cagcgacgga atcatcaagt ctttgtgacc aaacctatca acagaagatt ggcgatctca
    19261 attagttgtt taagtgtctt gctcttttcg gttaacttat ttttaagcga aaccgatcgt
    19321 cctcaattgc ttcaaagaat ttttgaccgt aattatattg taaaatatct tggcttggat
    19381 gcattcacag ccatcgatgg tgtcaaaaca gccatgtcaa atgaggtaag agcagaagct
    19441 agttcaaacg aattacctga aatcatgaaa tttaccaagc aaaacaattt accgcttaat
    19501 ccacagtatg ccgggattgc caaaggaaaa aatgtatttg tgattcattt agaaagtttt
    19561 caacaatttt tgattaatat gaaagtccaa ggccaagagg ttacaccgtt tttaaatcag
    19621 ctctatcaaa acaaagcgac aatcagtttt gataatttct ttcatgaagt agggcaagga
    19681 aaaacgagtg atgcggagaa tatgttggaa acaggaacat tcgggctccc gcaaggctct
    19741 ctttttacac aattaggatc agacaatact ttcgaagcgg ctcccgcagt tttaggacaa
    19801 aaaggctata caaccgctgt tttccatgga aatgtgggga gtttttggaa tcgggaccat
    19861 gtgtataaaa acttaggtta tcaatacttt tttgatcggt catatttttc aaaagatgac
    19921 aaaatgctag gttacggtat tttagataaa caattgttgc gtgaatcagc tagtgagctt
    19981 gagcatttac agcagccatt ctatgcgaag tttttaactg tgaccaatca taccccttat
    20041 tatacggatg accaaaactt cccgtttcct aaattgaaca caggcaattc gattgtggat
    20101 gattatgttc gaacagcgca ctatttggat caatcgctag aacaattttt ccattacttg
    20161 caaacaacaa gtttatacaa tcattctatt tttgttattt atggtgacca cttcggtatt
    20221 tcagatgcga acaacaagga cttatgtaaa gccttcaacc gcgatccaaa aacgtggaca
    20281 aactatgaca atgcgcaatt gcaaagagta cctttgatgt tttacatgcc aggctatacg
    20341 caagggaaaa tcatgcacga atatggtggg gaaattgacg ttttaccgac actgtaccat
    20401 cttttaggtg tcgatgataa aaattatatc cattttggca cggacctttt atctcctcaa
    20461 tataaacaag tggttccttt tagaaatggc gattttgtaa cgcctcaatt ttcgtatcta
    20521 ggtggggaaa tctacaataa tcaaggaaaa aaattagacc aagttccagc agatttaaaa
    20581 gcagaagtca cgaaagataa cgattgggtg aaaaaatcgt taagtttatc tgacaaatta
    20641 aatcaggaaa accttttacg tttttataaa ccacaaggat tccaagaagt gcaaccaaag
    20701 gactacaact atgatgtagc ttttgaaaa
//
