LOCUS       NZ_CP116962            22985 bp    DNA     circular CON 10-MAR-2024
DEFINITION  Enterococcus faecalis strain DM86 chromosome, complete genome.
ACCESSION   NZ_CP116962
VERSION     NZ_CP116962.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 2959291)
  AUTHORS   Shen,W. and Cai,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JAN-2023) Clinical Microbiology Laboratory, The Second
            Affiliated Hospital of Zhejiang University School of Medicine,
            Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v.0.4.4
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore
            PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/10/2024 16:14:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,086
            CDSs (total)                      :: 3,005
            Genes (coding)                    :: 2,954
            CDSs (with protein)               :: 2,954
            Genes (RNA)                       :: 81
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 51
            CDSs (without protein)            :: 51
            Pseudo Genes (ambiguous residues) :: 0 of 51
            Pseudo Genes (frameshifted)       :: 18 of 51
            Pseudo Genes (incomplete)         :: 29 of 51
            Pseudo Genes (internal stop)      :: 12 of 51
            Pseudo Genes (multiple problems)  :: 6 of 51
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:47:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 324026
            Orig. end                         :: 347011
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116962.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22985
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22985
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22985
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12985](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12985
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            119..1600
                     /locus_tag="PO880_RS01495"
                     /old_locus_tag="PO880_01495"
     CDS             119..1600
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002368476.1"
                     /locus_tag="PO880_RS01495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01495"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002354844.1"
                     /transl_table=11
                     /translation="MILMMFLNKVDKRKIALFQLLENAPMLTESKETVMQELELSEFIV
                     NKTVAELNADFIEFGLSEDFQIVSDGIFLTLNESGTETSATLIDCYIKESLRFAMFQDF
                     FFQRFDSVNEFALEHFVSHTLAYKEFKELKKMLENYQITINKEFHLVGNETNLREVTTL
                     VFLQLYQRDFSLYGKKVLEQIRNFELFFSEKVHLNQRAGYAQAKCFHFLAVSLVRTQQQ
                     FYVEKKVDSQVLKQLAGDNQQNVFNWLESLQVPEPQRTNEGNYLLLFLIAEEWLQVASA
                     ALCQRFAEIQQLNRDLLSYLKIQFQLSEEVLQGFEQKVTIVHFKLFHFPIEANYSYRKM
                     DITYFAETYTEYFSASRQFIQEQKTNPAVWDARQFLFYRYLLLMVDALPLKKVLAPITL
                     CVDFSFGEAYNRMIQKNIEKITEWNIIFKAHVDESVQLILSDIHFVDWPEITQIIWLAP
                     PRPVDWSHFIKTLSALRPHSGEENKVGTAPLSSEK"
     gene            1837..2334
                     /locus_tag="PO880_RS01500"
                     /old_locus_tag="PO880_01500"
     CDS             1837..2334
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016618616.1"
                     /locus_tag="PO880_RS01500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01500"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_002354845.1"
                     /transl_table=11
                     /translation="MVFDGWKRKKQIRALETLVDTKYEKMYRIAFNYTHSKEDALDVIQ
                     ESFEKALKAIQKGPDIKDFEAWFFRILLSVATDYWRKKKREAVHIEKDEHVLALLNNPQ
                     RSFLEIEEIINQLDSPNREIILLKFFEGFTLKEIALILDINENTIKTKMYRSLNELRSL
                     LN"
     gene            2359..3243
                     /locus_tag="PO880_RS01505"
                     /old_locus_tag="PO880_01505"
     CDS             2359..3243
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402522.1"
                     /locus_tag="PO880_RS01505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01505"
                     /product="RsiV family protein"
                     /protein_id="WP_002370130.1"
                     /transl_table=11
                     /translation="MEDFVKSVVKNFSKEYRQQPLPTDLQAEVKARFHKEKKRYTWLRF
                     RNRSLQSSVVVACGFVLSVNLFPGFSEAARNIPVLDKIVQLVTIKTLTAKKQESEVNID
                     VPKIQTSQESSVADTLNKKYLKEAQTEFQQVKGQLFDGSRVSVTGDYEKVVDDRRFLVV
                     KRTFTEIKGSSATTTKYDTIDKRANVVVSLPLIFKNDFYIDVISSEIKQQIADQMKNDS
                     NKIYWSEKEDAPSDVQPFKKIKKDQPFYINEKHQLVIVFPQGEIAPYYMGTPEFVIPNQ
                     VIENELAAPNYLK"
     gene            3373..4509
                     /locus_tag="PO880_RS01510"
                     /old_locus_tag="PO880_01510"
     CDS             3373..4509
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002365400.1"
                     /locus_tag="PO880_RS01510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01510"
                     /product="ArgE/DapE family deacylase"
                     /protein_id="WP_010710866.1"
                     /transl_table=11
                     /translation="MEKSEKISILQDVVKIKSVNGNEEEVAIYLQNLLKKYEIPSELVS
                     YAPNRSSLVAYLGENREKVLGFSGHMDVVSEGDESQWTFPPFAAHIEGNKLYGRGATDM
                     KSGLVAMVLAMIELKEKEVPLKGAVKFLGTVGEEVGELGAGQLTEKGYADDLSALVIGE
                     PTNYNLMYAHMGSINYSVVSHGKEAHSSMPEEGINAINNLNEFITEANQQMAEVTANYE
                     NPELGRTIHNVTVIKGGTQVNSIPGQATLQGNIRSIPEFSNDQVIALLQKIIDELNKKE
                     KHQLELTIDYNKIPVKAEKDSALIQAIQAQFDQPLPLVTSAGTTDLAEFTKSDNTFDCV
                     VFGPGVTTTAHQVDEYVEIDNYLDMIDKYQAIAKSYLN"
     gene            complement(4563..5354)
                     /locus_tag="PO880_RS01515"
                     /old_locus_tag="PO880_01515"
     CDS             complement(4563..5354)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002367471.1"
                     /locus_tag="PO880_RS01515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01515"
                     /product="hypothetical protein"
                     /protein_id="WP_202492375.1"
                     /transl_table=11
                     /translation="MDLHLTVDLKKTKTLIDLADQAHIIIEQTTKLPKKEAAILFLLRD
                     NQLVALGLAEEKATYKEVSFDHSILLKPTWDTELAYLAQAFLDDAKESGLTLEATPTTV
                     KIPKSAVATVTNYKETVTFILERFGYSLFKKPAPKKARPAKARHKWTKEVSQIPFYIDT
                     RQSKATVFWQKRNEMLIKAGATMMPEAPLNKDGSVGFSARFGEKLRDERKGQFKDFVTT
                     EDIVLKSVNEVGLFLYFAGTNSWLELVDENGKTLNEWTVVE"
     gene            5518..5901
                     /locus_tag="PO880_RS01520"
                     /old_locus_tag="PO880_01520"
     CDS             5518..5901
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354850.1"
                     /locus_tag="PO880_RS01520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01520"
                     /product="YccF domain-containing protein"
                     /protein_id="WP_002358999.1"
                     /transl_table=11
                     /translation="MKTLGNILWFIFGGFFGGLSWLFAGVIWCITIIGIPIGLQCFKLA
                     GLSFWPFKKRVVYSDSGVSLVVNIIWLIISGLPLAIGHCISGLLLCLTIIGIPFGQQSF
                     KLAKLALMPFGARVVSTNDFYFE"
     gene            5990..6415
                     /locus_tag="PO880_RS01525"
                     /old_locus_tag="PO880_01525"
     CDS             5990..6415
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383201.1"
                     /locus_tag="PO880_RS01525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01525"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_002383201.1"
                     /transl_table=11
                     /translation="MAMSTKLSVAIHILSLIETGPQEQVTSEYIASSVNTNPVVVRRLM
                     SQLKKAGLIHSMRGANKNTLLKKPEEISLYEIYTAVELEREIFNIHQNPNPNCSVGANI
                     QSVLETEFTKVQQKMEEELKSITLADVIHEIEVKRDK"
     gene            6474..7103
                     /locus_tag="PO880_RS01530"
                     /old_locus_tag="PO880_01530"
     CDS             6474..7103
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354854.1"
                     /locus_tag="PO880_RS01530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01530"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_002354854.1"
                     /transl_table=11
                     /translation="MIYMKVAVLGATGKEGQLLLAEAKRRGMDVTAIVRNASKITDGTP
                     TIEKDVYQLTTEDIQAFDVLISALGFPDVQDFPKSTQHLIEILTNQKTRLFVVGGAGTL
                     YVDPEHTTQLKDTPSFPAEIQPLASAMGEALNLLKEAQNIHWTYISPAAMFDAEGPATG
                     HYEVAGEELTTNSQGDSYISYADYAVAMLDEVESNAHPNQRISVYQ"
     gene            7798..7887
                     /locus_tag="PO880_RS01535"
                     /old_locus_tag="PO880_01535"
     CDS             7798..7887
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013828.4"
                     /locus_tag="PO880_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01535"
                     /product="ATP-binding protein"
                     /protein_id="WP_229201793.1"
                     /transl_table=11
                     /translation="MNLRYEKKSTVLTSNIALFQWTEVFQDKR"
     gene            complement(8294..8647)
                     /locus_tag="PO880_RS01540"
                     /old_locus_tag="PO880_01540"
     CDS             complement(8294..8647)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002407847.1"
                     /locus_tag="PO880_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01540"
                     /product="hypothetical protein"
                     /protein_id="WP_002407847.1"
                     /transl_table=11
                     /translation="MSNEVKKMISLTWILFLVSIVTMISIGITFKFWGLKGLLIPVFEC
                     SLIAYIGFKIEIIRRRINIKSYNELLNILHYDSLKSTTSPSRKNFFLEKNLLAFLISFV
                     FFLLIISISFVIF"
     gene            complement(8765..9268)
                     /locus_tag="PO880_RS01545"
                     /old_locus_tag="PO880_01545"
     CDS             complement(8765..9268)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002424923.1"
                     /locus_tag="PO880_RS01545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01545"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_002424923.1"
                     /transl_table=11
                     /translation="MNTGEKIRKYRMEKNLSQVELSSILLVSRQTISNWENGRTRPEME
                     NLVLISNFFDVPLEVFLSEDISEIKKQHTEFTFTAKIIFIIFISICVLISSIFMSIKMS
                     KYFLVFPFLLLNIIFACLLTFFLRQTPEKSYLKKFNKLNFLFIILIMGLISFFSIYFLL
                     TLLN"
     gene            9422..9631
                     /locus_tag="PO880_RS01550"
                     /old_locus_tag="PO880_01550"
     CDS             9422..9631
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401134.1"
                     /locus_tag="PO880_RS01550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01550"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_002401134.1"
                     /transl_table=11
                     /translation="MEAEKIVGMQFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSY
                     VASAAGSAALSAVSGLVSYTKKCF"
     CDS_motif       9422..9448
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEAEKIVGM"
                     /locus_tag="PO880_RS01550_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9449..9631
                     /prepeptide="core"
                     /locus_tag="PO880_RS01550_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.60"
                     /molecular_weight="6041.7"
                     /monoisotopic_mass="6038.1"
                     /core_sequence="QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGS
                     AALSAVSGLVSYTKKCF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEAEKIVGM"
                     /leader_location="[9421:9448](+)"
                     /alternative_weights="6059.7"
                     /alternative_weights="6077.8"
                     /alternative_weights="6095.8"
                     /alternative_weights="6113.8"
                     /alternative_weights="6131.8"
                     /alternative_weights="6149.8"
                     /alternative_weights="6167.9"
                     /alternative_weights="6185.9"
                     /alternative_weights="6203.9"
                     /alternative_weights="6221.9"
                     /alternative_weights="6239.9"
                     /alternative_weights="6258.0"
     gene            9652..9849
                     /locus_tag="PO880_RS01555"
                     /old_locus_tag="PO880_01555"
     CDS             9652..9849
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002396812.1"
                     /locus_tag="PO880_RS01555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01555"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_002396812.1"
                     /transl_table=11
                     /translation="MDEKQLDSLVGQKFEDLSKEEMNFIAGGNDNARISPTIILSAATV
                     ASAASSFVGSYTLSAFTKCR"
     CDS_motif       9652..9735
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDEKQLDSLVGQKFEDLSKEEMNFIAGG"
                     /locus_tag="PO880_RS01555_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9736..9849
                     /prepeptide="core"
                     /locus_tag="PO880_RS01555_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.50"
                     /molecular_weight="3594.0"
                     /monoisotopic_mass="3591.9"
                     /core_sequence="NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDEKQLDSLVGQKFEDLSKEEMNFIAGG"
                     /leader_location="[9651:9735](+)"
                     /alternative_weights="3612.0"
                     /alternative_weights="3630.1"
                     /alternative_weights="3648.1"
                     /alternative_weights="3666.1"
                     /alternative_weights="3684.1"
                     /alternative_weights="3702.1"
                     /alternative_weights="3720.2"
                     /alternative_weights="3738.2"
                     /alternative_weights="3756.2"
                     /alternative_weights="3774.2"
     misc_feature    9953..9966
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.36"
                     /tool="antismash"
     gene            10001..12985
                     /gene="lanM"
                     /locus_tag="PO880_RS01560"
                     /old_locus_tag="PO880_01560"
     CDS             10001..12985
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401133.1"
                     /locus_tag="PO880_RS01560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01560"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_202492371.1"
                     /sec_met_domain="DUF4135 (E-value: 1.4e-86, bitscore:
                     288.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7.5e-48, bitscore:
                     160.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCFDKGKALTIEERMSLIKNKIFDDKNSSNIQRWLNRKTTVDSE
                     LFSKILNINNWKLEEFNHCIDENFKIDSYSDRVTYSDFDSLIASIEDQNNLPSTYVKLI
                     RPFLTKLENGLIVDFQDKLSEKAIENIFDCLASRLINLSLKVFVLEMDFIKNSNGLHGE
                     TSKERFINFIDLYDDKEKLLNLYQKYPVMTRKLSITTLYFIDFMNEFLNNLFQSWDSIE
                     DTFFDTEEKIYVESLIFEKGDTHEKEKSVVIIEFNLGKIVYKPRNLYIEKNFQKIIKFF
                     SYSNGFLNMDIPKSLYNSTFTFVQFIEQEPCNNEEEIERFYQRYGQLIALIYLTNGSDI
                     HFENVISHGEYPVIVDYETLFSVPIKLEGRQENIFSEIVGFIRNSVSSSIMLPGKMQLD
                     SEGNSVDISGLSGKTQKLEKKMYVPKNLDNDNAKFVLENVILEGSNNNVFYKDKLINYQ
                     DYYKEIIAGFSNVMDFFLVNKEEYLNLIEGMENNTIRILARNTNTYAQFLEFTKHPNCL
                     KDFVELEKILENLYTFPYENKQISQLEYKDMVFDDIPIFFSKLDENCIYNSEGVRIQNV
                     FENTPRIFLIDKIKNIDSENIAKQIGIIMMKIKGEEGVVKQDVSSLVISKEDSYLQIAE
                     KLAEKLIDSAYIDKNEEYMTWLVINDGVVDEFDLGASKVNFYDGLIGIASLFKSLYKVT
                     GKVKYQRYFDYLVKTTMDLLDTMQTDSAYVGFHSFLQLFSIIEKEDTNYERITHYLNLL
                     QQNSQNFLEREGTVDWLLGYGGIIPLYIDVYKKTKDNQYLEIAIFLGNKLIMFAEKDTN
                     VMKNIGIGHGISGLLISMVELYKVTKDRQYLEYIKKLNERMSISLVQENEDVVSWCNGI
                     LGYLLGQSYLHKNNIKSALSDKEKQRLLLKIKNQYLESDCLCHGNCGIIQFYIDLYLLE
                     NSDKYLEHAKKIGNKMISEIIKNEYIQIREFEGFDNIGLFNGISGVAYTLVRLLEPENV
                     PSVFV"
     gene            13011..13712
                     /locus_tag="PO880_RS01565"
                     /old_locus_tag="PO880_01565"
     CDS             13011..13712
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002396816.1"
                     /locus_tag="PO880_RS01565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01565"
                     /product="flavodoxin family protein"
                     /protein_id="WP_010710868.1"
                     /transl_table=11
                     /translation="MKKILAIIGSRDKNSETLSIVNRIKETVQDLNASFEFEIITPYDY
                     NLNFSDSPRLAFIKGADTNEQDERDDSKKIKAKIENASLVILASPTYFANVSADIKLFI
                     DRFCHLAHLFYFAKKPCITVVTSDGNGHIQTSNYLKSFCDGLGMVRVQEIISIRSNPIS
                     ENEIEASVREGLKYISNPQKISPNLSMEMSFQHWKKSISKQNETLSEYRYWENSGLFSC
                     NSLEEYFDRYR"
     gene            13719..15848
                     /locus_tag="PO880_RS01570"
                     /old_locus_tag="PO880_01570"
     CDS             13719..15848
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002424924.1"
                     /locus_tag="PO880_RS01570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01570"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_002424924.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.8e-33, bitscore:
                     110.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIKVVYQNEHSECGIAVVTSILNFFGSRVTINDLRDKYGSPKG
                     GLTFGNMNYIMKKFGLIYHGIKINDTDYLKNQKKPVILFWDNNHFVVFYKYKRGHFYVM
                     DPKLGKVVYTKHEFEEHFSLYALVFKEINYNDGKKEIKINLKNKTKELICSLLRSTKSI
                     IILMIFVIFLSKMLSLIVPVLTQRLIDNYQILANLSLATLIGGTILIAGIYYLITVSYS
                     LLLTKLQLSWSKKLSNKFMEKVFIKSLNFFVNRSSGSMIYKANLITMVQQMLSKNTIEN
                     IIDYLFMIVYFIYLTNYSSKLTIITIIFCLLILINSLTYSKINYKINGRVIEYQSEIQS
                     LYVEIFSGMETIKSLGKEKVFFTRWSNIFSNSLKSLSQQGKAAAWLSGISTTLLFTLPI
                     IILFFGIHEVQANQMSLGQLIGFTTLIAYFIEPFSTMIGSISQILILKSYLNQISDVTN
                     TDFYNEINGKKKFERFENLKMNNVNFSFSEFEKNVISSVNLEIKKGEKVAIVGKSGSGK
                     STLLKLICGLFIPSEGQVIYNNEEISSFDKSSLRNKVGYVTQSSIVFGNTLEENLMVGD
                     ESPIVVKEVLTATGINELVDNDMLGLNTIISENGMNLSGGQKQKISIARCLLKNPDVII
                     MDEPTSSLDNVSEKKIMDYILNNCKTSVIVAHRLNTIKNMDRIIVLDKGRVVEEGNHEQ
                     LLEMQKVYYSLYNEM"
     gene            15852..16115
                     /locus_tag="PO880_RS01575"
                     /old_locus_tag="PO880_01575"
     CDS             15852..16115
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002396818.1"
                     /locus_tag="PO880_RS01575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01575"
                     /product="hypothetical protein"
                     /protein_id="WP_002396818.1"
                     /transl_table=11
                     /translation="MRYSLEDRADNRINAVAAVYKDESKDLIRESNTHRCGVCGEEKTC
                     TTILDFDNLIRKNMLNIKYDYKFNQCVALYDRKEEFNLVKRM"
     misc_feature    complement(15856..15873)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 24.35"
                     /tool="antismash"
     CDS             complement(16586..16729)
                     /gene="allorf_0340612_0340755"
                     /locus_tag="allorf_0340612_0340755"
                     /protein_id="allorf_0340612_0340755"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGAPRNICTENSDSD
                     YL"
     CDS_motif       complement(16631..16729)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA"
                     /locus_tag="allorf_0340612_0340755_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16586..16630)
                     /prepeptide="core"
                     /locus_tag="allorf_0340612_0340755_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="1572.6"
                     /monoisotopic_mass="1571.7"
                     /core_sequence="PRNICTENSDSDYL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA"
                     /leader_location="[16630:16729](-)"
                     /alternative_weights="1590.7"
                     /alternative_weights="1608.7"
     gene            <16839..16949
                     /locus_tag="PO880_RS01580"
                     /old_locus_tag="PO880_01580"
                     /pseudo=""
     CDS             <16839..16949
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002334253.1"
                     /locus_tag="PO880_RS01580"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="PO880_01580"
                     /product="type II toxin-antitoxin system mRNA interferase
                     toxin, RelE/StbE family"
                     /pseudo=""
                     /transl_table=11
                     /translation="E"
     gene            complement(17177..18382)
                     /locus_tag="PO880_RS01585"
                     /old_locus_tag="PO880_01585"
     CDS             complement(17177..18382)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016627528.1"
                     /locus_tag="PO880_RS01585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01585"
                     /product="hypothetical protein"
                     /protein_id="WP_002367468.1"
                     /transl_table=11
                     /translation="MSVVLVLLGLLGLLVSGGLTIKALIKKQPKKQYGYAALASAALFI
                     GGVATTDSSPTLSLDAESVETDANGSATIKGEYDGNSKLTANGKEVKTKDKTFAYKVKL
                     SDEKTQKITFVAEKKDTKVEKSVEVTPSKEFIASITDSEQELAKTEKALAYAEKQPSQK
                     NYDEAATLVSSLSQEYEEYNDRLEKIKEAVPVDEAVTTAEKSKSKSDYQAAEKLVAAAP
                     VGKEGFQQRLTTVQTAIAEKEKNEQLVASATAAVEKAEQEPTNEAYYNEAVKQIDALNS
                     PNQALTKRVAVVKTQLDAHKEKQRKEAEAQKLAAEKAQKEQAEAAAKAQAEAEAQQAAQ
                     APAEVETAAAEAPSGNALIKGSRNGIYHVPGSRYYNRTTNPVAWFSTVEEAEAAGYRAP
                     KQ"
     gene            18574..19818
                     /locus_tag="PO880_RS01590"
                     /old_locus_tag="PO880_01590"
     CDS             18574..19818
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002365395.1"
                     /locus_tag="PO880_RS01590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01590"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_010710870.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTELLLGQVVNTNATFLSEELAALGIDVYYQTVVGDN
                     GGRLETLLTEAEQRSDLIVLCGGLGPTEDDLTKQVVAQHLHKSLVEDQEGLNRLHQFFQ
                     QSKRPMTENNLRQVLAIEGGQVLQNPTGLAVGSFVTEGTTSYLLLPGPPNELIPMFQQA
                     ARPLLIDAFPQEEQLISRVLRFYGIGESQLVTEIQSLIAHQTNPTIAPYAKPNEVTLRL
                     TVKTKDLVAGEELLTATEEKVLAKVGDYFYGYGDDNSLAKVTVDLLLQNGQTVTAAESL
                     TAGLFQSTLGEIAGASKIFKGGFVTYSQETKENFLGISHELLEEHGTVSEACAKEMAEK
                     ARQLAKSNYGLSFTGVAGDPIEGQPTGTVWIGLAEEGQPTVAECFHFNRDRNYIRQSAV
                     MRGLDLLRRRIINKK"
     misc_feature    19823..19838
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.58"
                     /tool="antismash"
     misc_feature    complement(19824..19837)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.72"
                     /tool="antismash"
     gene            19932..20978
                     /gene="recA"
                     /locus_tag="PO880_RS01595"
                     /old_locus_tag="PO880_01595"
     CDS             19932..20978
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354860.1"
                     /locus_tag="PO880_RS01595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01595"
                     /product="recombinase RecA"
                     /protein_id="WP_002354860.1"
                     /transl_table=11
                     /translation="MADDRKVALDAALKKIEKNFGKGSIMKLGEKADQKISTIPSGSLA
                     LDVALGVGGYPRGRIIEVYGPESSGKTTVSLHAIAEVQRNGGTAAFIDAEHALDPQYAE
                     KLGVNIDELLLSQPDTGEQGLEIADALVSSGAIDIVVIDSVAALVPRAEIDGEMGASHV
                     GLQARLMSQALRKLSGSINKTKTIAIFINQIREKVGVMFGNPETTPGGRALKFYATVRL
                     EVRRAEQLKQGTDIVGNRTKIKVVKNKVAPPFKVAEVDIMYGQGISQEGELLDMAVEKD
                     LISKSGAWYGYKEERIGQGRENAKQYMADHPEMMAEVSKLVRDAYGIGDGSTITEEAEG
                     QEELPLDE"
     misc_feature    complement(21085..21099)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            21375..22931
                     /gene="rny"
                     /locus_tag="PO880_RS01600"
                     /old_locus_tag="PO880_01600"
     CDS             21375..22931
                     /GO_function="GO:0004521 - RNA endonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rny"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005875117.1"
                     /locus_tag="PO880_RS01600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PO880_01600"
                     /product="ribonuclease Y"
                     /protein_id="WP_002354863.1"
                     /transl_table=11
                     /translation="MVLNILLAIVGLIVGLGLGFVIAKSRHDKAINGAKISASSILENA
                     RKESETLKKEALLEAKEENQKYRSEIESELKESRLELKSQENRLIQREQTLDRKDDSLE
                     KREGSLEEKEEKLGARQQLIDEREKEVENLINQQHQELERIASLSKEEAKSIIMKSTEE
                     ELNHELTLMVKESEQRAKEESDRKAKNLLSLAIQRCAADSVSETTVSVVTLPNDEMKGR
                     IIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPIRREIARMTLEKLIQDGRIHPAR
                     IEEMVEKSRKEMDERIREYGEQAAFEVGAHTLHPDLIKILGRLRFRTSYGQNVLNHSIE
                     VAKLAGVLAAELGEDVQLAKRAGLLHDIGKALDHEIEGSHVEIGAELAAKYKENSVVIN
                     AIASHHGDVEATSVISVLVAAADALSAARPGARSESLENYIRRLENLENISNSFEGVDS
                     SFAVQAGREVRVMVKPEEISDLESVRLVRDIRKKIEDDLDYPGHIKVTVIRETRAVDYA
                     K"
ORIGIN
        1 tttcctaacg gacttggtgc aggcggcgat gaagaatctg aaagctattt agcagcggtt
       61 gggtactttc tttcaggaaa tggattgtat gggaaaaaaa tggatgtgag agaagtctat
      121 gatattgatg atgtttttaa ataaagtgga taaaagaaaa atcgccttat ttcagttact
      181 ggaaaatgca ccgatgttaa cagagtcaaa agaaaccgta atgcaggagt tagaattatc
      241 tgaatttatc gtgaacaaaa cggtcgctga attaaatgcc gattttattg aatttggttt
      301 atcagaggat tttcaaattg tgagcgatgg tattttctta acgcttaatg aatcaggaac
      361 ggaaacttcc gctactttga ttgattgcta tattaaagag tcgttacgtt ttgctatgtt
      421 tcaagatttc ttttttcagc gttttgattc tgtaaatgag tttgctttag aacactttgt
      481 tagtcacaca ttggcttata aggagttcaa ggaattaaag aaaatgctgg aaaattatca
      541 aattacaatt aataaagaat ttcacttggt gggaaatgaa accaatttac gcgaagtaac
      601 aacactggtt tttttacaat tataccaacg tgatttttca ttgtacggta aaaaagtttt
      661 agagcagatt cggaactttg agctattttt ttctgagaag gttcatctta atcagcgtgc
      721 aggctatgca caagctaaat gttttcattt tttggcggtt tctttagtac gaacgcagca
      781 acagttttat gtagagaaaa aagtagattc gcaagtgtta aaacaattag ccggtgacaa
      841 tcagcagaat gttttcaatt ggttagagag tcttcaagtc ccagaaccac aacgaacaaa
      901 cgaaggcaat tatttactct tatttttaat tgctgaagag tggcttcaag tagcttcagc
      961 agcactttgc caaagatttg cagaaattca acaattgaat cgtgacttgt taagctattt
     1021 aaaaatacaa tttcagcttt ccgaggaagt cctgcaaggt tttgaacaaa aagtaacaat
     1081 cgtacatttt aaattgttcc attttccaat agaagcaaac tatagttatc gcaaaatgga
     1141 tataacctac tttgcagaaa cgtatacaga gtatttttct gctagtcgac aatttattca
     1201 agaacaaaaa acgaatcccg ctgtttggga tgccagacag tttttatttt atcggtatct
     1261 gttgttaatg gtggatgcgt taccattgaa aaaagttttg gctccgatta cattgtgtgt
     1321 cgacttttcc tttggtgaag cctataatcg tatgatacaa aaaaatattg aaaaaattac
     1381 ggaatggaat atcattttca aagcacatgt agatgaaagt gtacaattaa ttttatcgga
     1441 tattcatttt gtcgattggc ctgagattac ccaaattatt tggctagcgc caccacgtcc
     1501 tgttgattgg tcgcatttta ttaaaacgct gagtgcacta agaccgcact cgggagaaga
     1561 aaacaaggtc gggacagcac cgcttagctc cgagaaataa gaagaaattt ccggaaattg
     1621 ttctttaatt tttggataat ttcggcttat ttccgaagga gctggttctg ttcccgccgt
     1681 ttatcagatt ttgagcgtgg agcaaaaatc caaagtgatt tttgtaccgc gctttttctt
     1741 ttagaatata aaaattaaaa ataataaaaa agttgaaact ttttatgctt gtgattcgtc
     1801 tatataagtg tacaggaaag gaggttccag aaatcgatgg ttttcgatgg ttggaaaaga
     1861 aaaaaacaaa ttcgcgcgtt agaaacgctt gtggatacca aatatgaaaa aatgtatcgc
     1921 attgccttta actatacaca ttcgaaagaa gatgccttgg atgtgattca agaaagcttt
     1981 gaaaaggcac tgaaggccat ccaaaaagga cccgatatta aggattttga agcgtggttc
     2041 tttcgaattc tgctttctgt agcgacagat tattggcgta aaaagaaacg agaagctgtt
     2101 catattgaaa aagatgaaca tgtgttagcc cttttaaata atccccaacg cagtttttta
     2161 gaaattgaag aaattattaa tcaattagat agtcccaatc gtgaaattat tctattaaaa
     2221 ttttttgaag gatttacgct aaaagaaatc gccttgatcc tggatattaa cgaaaacacg
     2281 attaaaacga agatgtaccg cagtttgaat gaactccgaa gtctattgaa ttagtaaaag
     2341 aaaggaagcg aaaaaataat ggaagatttt gtaaaaagcg ttgttaaaaa cttttcaaaa
     2401 gaataccgcc aacaaccgtt gccaacggat ctacaagcgg aagtcaaagc gcgttttcat
     2461 aaagagaaaa agcggtacac ctggcttcgt tttagaaacc gctcactgca aagtagtgta
     2521 gtggtggctt gtggctttgt cttatcagtc aatttgtttc caggttttag tgaagcagcc
     2581 cgcaacattc ctgtgttaga taaaattgtt caattagtca ccataaaaac gttgacagcg
     2641 aaaaaacagg aaagtgaagt aaacatcgat gtccctaaaa tccaaacatc ccaagaatct
     2701 tcagtagccg acacgctcaa caaaaaatac ttgaaagaag cccaaacaga atttcaacaa
     2761 gtcaaagggc aattgtttga tggttctcgt gtttcagtca ctggagatta tgaaaaagtc
     2821 gtggacgacc gtcgcttcct agtggtcaaa cgaaccttca cagaaattaa aggcagttct
     2881 gcgacgacaa caaaatatga caccatcgat aaacgagcca atgttgtcgt ttcactcccc
     2941 ttaattttta aaaatgattt ttacattgat gtcattagta gtgaaattaa acaacaaata
     3001 gcagaccaaa tgaagaacga tagcaataaa atatactggt ccgaaaaaga ggatgccccc
     3061 agtgatgttc aacccttcaa aaaaattaaa aaggaccaac ctttctatat caatgaaaaa
     3121 caccaattag tgattgtgtt tcctcaagga gagattgcgc cttactatat gggcacccct
     3181 gaatttgtga tccctaatca agtcattgag aatgaattgg cagcgcctaa ttatttaaaa
     3241 taaactcagc aaaaaacacg cgacagtttt aagaaatgtc gcgtgttttt aactgaccta
     3301 accaagtcag ttgcggtttt actgagagaa gcgtacacta gaattaagca taacaagaaa
     3361 gggcgaatgg caatggaaaa atcagaaaaa attagtattt tacaagatgt ggttaaaatt
     3421 aaatctgtaa atggaaacga agaagaagtg gcaatctatt tacaaaatct tttgaagaaa
     3481 tatgagatcc cttctgaact tgtttcttat gcaccaaatc gtagtagttt ggttgcttac
     3541 ctaggtgaaa accgagaaaa agtcttaggg tttagtggcc acatggacgt ggtttctgaa
     3601 ggggacgaaa gtcaatggac tttcccgcca tttgcggccc atattgaagg aaataaattg
     3661 tatggccgtg gcgcaacgga catgaaaagc ggcttagtcg caatggtttt agcaatgatt
     3721 gaattaaaag aaaaggaagt tccattaaag ggagcggtta aatttttagg tacagttggt
     3781 gaagaagtcg gtgagctagg tgctggccaa ttaactgaaa aaggctatgc ggatgattta
     3841 agtgccttag tcattggaga accaaccaat tataacttga tgtatgcgca catgggttca
     3901 attaactatt ctgttgtgtc gcacggaaaa gaagcccaca gttcgatgcc agaagaaggc
     3961 attaacgcga ttaataattt gaacgaattt attacagaag caaaccaaca aatggcggaa
     4021 gtcacagcaa actatgaaaa tcctgaatta ggtcgaacga ttcacaatgt aaccgtcatt
     4081 aaaggtggca cacaagtgaa cagtattcca ggtcaagcaa ccttgcaagg gaatatccgt
     4141 tcaattccag aattcagcaa cgaccaagtc attgcattat tacaaaaaat tatcgatgaa
     4201 ttgaacaaaa aagaaaaaca tcagttagaa ttaacgattg attacaataa aattcctgta
     4261 aaagctgaga aagattctgc gttaattcaa gccattcaag cccaatttga tcaaccatta
     4321 ccattagtga caagcgctgg gaccacagac ttagctgaat ttactaaatc agacaataca
     4381 tttgattgcg ttgtctttgg accaggtgtg accactactg cacaccaagt cgacgaatat
     4441 gtcgaaattg ataattattt agatatgatt gataagtatc aagcgatagc aaaaagttat
     4501 ttaaattaaa aaaatgtcgc gcctgaatca taaaaatcag gtgcgacatt tttttataag
     4561 gtttattcca ccacagtcca ttcatttaag gttttgccgt tctcatcaac tagctctaac
     4621 cagctgtttg ttccagcaaa atagagaaac aagccgactt cattaacgct ttttaagacg
     4681 atatcttccg ttgtgacaaa gtctttaaat tggcccttgc gttcatcacg aagtttttca
     4741 ccaaatctag cggagaaacc gacagacccg tctttattta aaggggcttc gggcatcatt
     4801 gtcgcgccag ctttaataag catttcattg cgcttttgcc aaaaaacagt tgctttgctt
     4861 tgtcgagtat caatataaaa aggaatttgg ctgacttctt ttgtccattt gtggcgtgct
     4921 ttggctggtc tggctttctt cggcgccggt tttttaaaca gagagtagcc aaaacgttcc
     4981 aagataaagg tgactgtttc tttatagtta gtcactgtcg ctaccgcact tttcggaatt
     5041 ttgactgtcg ttggggtcgc ttccaatgtt aaaccacttt ctttcgcatc atctaggaaa
     5101 gcttgcgcta aataggcaag ttctgtgtcc caagtcggtt tcaacaaaat cgagtgatca
     5161 aaagaaactt ctttatatgt agctttttct tcagcaagtc ctaaagcaac tagttggtta
     5221 tctcttagca agaaaagaat cgctgcctct tttttcggta atttagttgt ttgttcaatg
     5281 attatgtggg cctgatcggc taaatcaatg agtgtctttg ttttttttag atcaacggtt
     5341 aaatgtaagt ccatgaagtc tactccttta tcgttagttt cttcattgta tcatgaaaca
     5401 gcgtcttcgt cttttaacga gtcagcaacc ttacaatatt gtttgaaaca aaaagaagct
     5461 ttcgtggtat acttactcac atacataatt tttaatgagg aaagtagagg aacaagaatg
     5521 aaaacacttg gcaatatttt atggttcatc tttggcggct tttttggtgg cttatcttgg
     5581 ctattcgcag gcgtgatttg gtgtattaca attatcggta ttccgattgg tttacaatgt
     5641 tttaaattag cggggttgag cttttggccg tttaaaaagc gagtcgtgta tagtgatagc
     5701 ggcgtatctt tggtggtaaa cattatttgg ctgattatca gtggactacc attagcaatt
     5761 gggcattgta ttagtggctt gttgctttgt ctgacaatca tcggtattcc gtttgggcaa
     5821 caatccttta aattggcgaa attagcgtta atgccgtttg gggcccgtgt tgtttcaaca
     5881 aatgattttt attttgaata gtcagaggtt tctcattgac aaataaaacg aaacagcgta
     5941 ttctgtaaat gtaacaaata acgttacatt tagtttggag tgattagaca tggccatgtc
     6001 aacgaaatta agtgttgcga ttcatatttt aagtttgatt gaaacaggtc ctcaagaaca
     6061 agtgacttct gaatacattg cttcgagcgt gaatacgaat ccagtcgttg ttcgacgact
     6121 aatgagccag ttaaaaaaag ccggcttgat tcattccatg cgtggagcca ataaaaatac
     6181 cttattaaag aaaccagaag agatctcact gtatgaaatt tatacagcgg ttgaattgga
     6241 acgagagatt ttcaatatcc atcaaaatcc taatccaaac tgttccgttg gggcaaatat
     6301 ccaatcggta ctagaaactg aatttactaa agtgcaacaa aaaatggaag aagaattgaa
     6361 aagcatcacc ttagcagatg tgattcatga aatagaagtt aagagagata agtaatctct
     6421 ctacttttaa agtattaaat gtaactattt tagttctatt taaaaatgaa aggatgattt
     6481 acatgaaagt agcagtatta ggagcaacag gaaaagaagg acaattactt ttagcagaag
     6541 ctaaacgtcg cgggatggac gtgacagcca tcgttcgtaa tgcctcaaaa ataacagatg
     6601 gcacaccgac cattgaaaaa gatgtttatc aattaacaac agaagatatt caagcgtttg
     6661 atgtattaat tagtgcctta ggattccctg atgtgcaaga tttcccaaaa tctacccagc
     6721 atttgattga gattttaacc aatcaaaaaa cgcgcttgtt tgtcgttggg ggcgctggaa
     6781 ccttgtatgt ggacccagaa cacacaactc aattaaaaga tacaccatca tttccagcag
     6841 aaattcagcc attagcttcg gcgatgggcg aagctttaaa cttattgaaa gaagctcaaa
     6901 acatccactg gacctatatt agtcctgcag ccatgtttga tgctgaaggt cctgcgacag
     6961 gccattatga agtcgctggc gaagaattaa caaccaatag tcaaggtgac agctacatta
     7021 gttacgcaga ctacgccgtt gccatgttag atgaagtgga aagtaatgca cacccaaatc
     7081 aacgaattag tgtgtatcaa taaaagaaaa aattattaat acaaaaaata tactaagatt
     7141 agaggtatcc tctagggctg ttttaagcgt atagttggtt gtaaaaggaa gaccgaccac
     7201 actctctagg actgtgagta caaacaaaaa atgatctcct tcactgtcat ttaaaatctg
     7261 gtttaagtat ggtaggcttc gagaccgtgt gtaggagatg aaaatcatgt atgtacttgc
     7321 tttagatgtc tcaatgggaa aaagttatgc cgttaaaaaa gctccgctca aaaagcttta
     7381 acgaaagcac aagctttact ttcgttggca taaaatacct atctagcaga gtctggacaa
     7441 acgtcaatga ggtctaaccc gccctcacca actacaatga aaacaatcga cctacaaaca
     7501 atttttctgt catattaaaa ctgtcagaag tggtttgtag gtcgattaat aatcgagttt
     7561 cttttccaag ttaccttgag ggacaaacta aatcattata cttatttgta tcaaacatta
     7621 gctcatagaa tctgcgtata aaaagtattt acaaaataaa aagaccatag taaccgagaa
     7681 tgattaatat gggatatatc aatattgttt gactacgtaa ctaagtgaag gtagtctttt
     7741 ttgtttttag agtgaagttg tcgtataaaa aatagggcga atttcttttt ccagctcatt
     7801 aacttacgtt atgagaaaaa atcaacggtt ctaacatcca atatagctct gttccaatgg
     7861 acagaggtat tccaggataa aaggtaaaga atgtgattat tgatcatcta atccatcatt
     7921 ctaaaatttt atcaatcaat aagaaatctt atcgaatgaa agattacatg gaaacgaagg
     7981 gcctcgatat tgaaaaatag cagagagcca aaacatacat ctttatatgg cccttgacac
     8041 tgaatagatt ttgactataa aagtggttta gtattttaga tatatttaat tttagtttca
     8101 tgtcaatatt tattgacacc gctatttatc ggggcaaaag caccgccagc taaaaaggaa
     8161 attgatacag ctacagtaaa atcacttttt tgtaaattat acgtgtaaat gatcttgacc
     8221 tgacaaaaaa acagtaagtc agattaagat cattaaaaat aaatcgacaa aacaattatc
     8281 tattttaatt ttatcaaaat attacaaagc ttatcgaaat gattaatagg aaaaagacaa
     8341 aagagattag aaaagcaagc aggttttttt caaggaaaaa attttttctt gagggtgaag
     8401 ttgtagattt cagagaatca taatgtagaa tatttagcaa ttcattgtag gacttaatgt
     8461 tgattcttct tcttattatt tcaattttga aacctatata tgctattaaa ctacattcaa
     8521 aaacaggtat caataatcct ttcaaccccc aaaatttaaa agtaatacca atggaaatca
     8581 ttgttacgat ggatactaaa aataaaatcc aagttaaaga aatcattttt tttacttcgt
     8641 tactcatttc aattgctcct ttcagataat aatatatacg ttacaagtgt agcatataca
     8701 aaaataagaa ggattaatag cgtaatagtt ttatttagta aagactataa aggtttttta
     8761 cattttaatt taaaagagtt agcaagaaat aaatagagaa aaaactaatc aaacccatga
     8821 tgagaataat aaataagaag ttcaacttgt tgaatttttt taaataagat ttctctggtg
     8881 tttgcctaag aaaaaatgtt aatagacagg caaaaattat atttaatagc aaaaaaggaa
     8941 aaacaagaaa atatttactc atttttatag acatgaaaat acttgaaatc aatacacaaa
     9001 ttgaaataaa aattataaat ataattttag ctgtaaatgt aaattcggtg tgttgctttt
     9061 taatttctga gatatcttct gatagaaaaa cctctaatgg tacatcaaaa aaattactga
     9121 ttagtactaa attttccatt tctggtctag ttcgtccatt ctcccagttc gaaattgttt
     9181 gtctagaaac taatagtatt gatgaaagtt caacttgaga cagatttttt tccattctat
     9241 attttcgaat tttttctcca gtattcataa aaacctccgt tgataaaaga attaaccatt
     9301 tgtataatat attttgcata tgtaaaatgt ataacaaatg gtactttatt ttttatatta
     9361 tcatgataac atgaagatgt gttaacacgc tatataattt ttgaaaggaa gggattgtat
     9421 tatggaagca gaaaaaattg ttggtatgca atttgaagat ttatccaaag aagagatgaa
     9481 ctttattgct ggaggaaata ataacgctag aatttctccg actattgtta ctcctgtcac
     9541 accatacaca agttatgttg catcagcggc tggctctgca gctttgtcag ctgttagtgg
     9601 tcttgtctca tatactaaaa aatgttttta atatgaaagg gagagattat attggatgaa
     9661 aaacaattag actcgttagt aggtcaaaaa tttgaagatt tatcaaaaga agaaatgaac
     9721 tttattgctg gtggaaacga taacgctaga atttcaccta caattattct ttctgctgcc
     9781 actgtagcaa gtgctgcaag ttcattcgta ggatcgtata cattgtctgc ttttacaaag
     9841 tgcagataat aaagtgtttt taattgataa gtagaaataa aaatatatgt ttcattctat
     9901 ttgttggaat ttgaaatgta tggaattaaa ttcaacgaat ttaattccat acatttttta
     9961 aaacaataat tatatacata atactttagg agggggattt atgaactgtt ttgacaaggg
    10021 gaaagcatta actatagagg aaagaatgag tttaattaag aacaaaatat ttgatgataa
    10081 aaatagtagc aacattcaaa gatggcttaa tagaaaaaca actgtggata gtgaactttt
    10141 cagtaagatt ctaaatatca ataattggaa actagaggaa tttaaccatt gtatagacga
    10201 aaattttaaa atagattctt acagtgacag agtgacgtac tctgatttcg atagcttgat
    10261 agcatctata gaggatcaaa ataacttacc tagtacctat gttaaattaa tcagaccatt
    10321 tttaacaaaa ctagagaacg gcttaattgt tgattttcag gataaattat cggaaaaagc
    10381 tatagaaaat attttcgatt gtttagctag tcgattaata aatctaagtt taaaagtctt
    10441 tgtgttagaa atggatttta ttaaaaatag caatggactt catggtgaaa catcaaaaga
    10501 aagatttata aattttatag atttgtatga tgataaagaa aaattgttga atctgtatca
    10561 aaaatatcca gtaatgacaa gaaaattgag tataacaacc ttatatttta ttgatttcat
    10621 gaatgaattt ctgaataatt tatttcaatc atgggattca attgaagata cattcttcga
    10681 tacagaagaa aaaatatatg tagaaagttt gatatttgaa aaaggcgata ctcatgaaaa
    10741 agaaaaaagt gttgttatta tagagtttaa tttgggaaaa attgtttata aacccagaaa
    10801 cttatatata gaaaagaatt ttcagaaaat tataaagttc ttttcttata gtaatggatt
    10861 tttaaatatg gatatcccaa aatctttgta taattctaca ttcacttttg ttcaatttat
    10921 cgagcaagaa ccttgtaata atgaagaaga aattgaaaga ttttatcaac gatatggtca
    10981 gctaattgca ttaatctatt taactaatgg tagtgatatt cattttgaaa atgtaatttc
    11041 tcatggagag tatcctgtta tagttgacta tgaaactttg ttttcggttc ctataaaact
    11101 tgaaggaaga caagaaaata tattcagtga aattgtgggg tttattagaa attctgtatc
    11161 gtctagtatt atgctaccgg ggaaaatgca attagattca gaaggaaata gcgttgatat
    11221 tagtgggctt agtgggaaaa ctcaaaaatt agaaaaaaaa atgtacgttc caaaaaattt
    11281 agacaatgat aatgcaaaat ttgtattaga gaatgtcatt ttagaaggca gtaataataa
    11341 tgtgttctat aaggataaac ttattaacta tcaagattac tataaagaaa ttattgctgg
    11401 ttttagtaat gtaatggact tctttttggt taataaagaa gaatatctga atctaattga
    11461 aggcatggaa aataatacaa ttagaatatt agcaagaaat acgaacacat atgctcaatt
    11521 tttggagttt actaaacacc caaactgttt aaaagatttt gttgagttag aaaagatatt
    11581 ggaaaattta tatacattcc cttatgaaaa taaacagata tctcaattag agtataaaga
    11641 tatggttttt gatgatatcc caatattttt ttcaaagcta gatgagaatt gtatctacaa
    11701 ttcagaagga gttaggatac aaaatgtttt tgaaaatact cctagaatat ttttaattga
    11761 taaaattaaa aatattgatt cagaaaatat tgctaaacag atagggatta ttatgatgaa
    11821 aatcaaaggt gaagagggag ttgtaaaaca agatgtatca agtttagtaa taagtaagga
    11881 ggatagttac ctacagatag ctgaaaaatt agctgaaaaa ctaattgact cagcttatat
    11941 cgacaaaaat gaagaatata tgacttggtt ggttataaat gatggtgtag ttgatgaatt
    12001 tgatttaggt gcttcaaaag tcaattttta tgatgggtta ataggaattg catcattgtt
    12061 taaatcgtta tataaagtaa caggaaaagt aaaatatcaa agatattttg attatttagt
    12121 gaaaactacg atggatcttt tagatactat gcaaacagat agtgcttatg tagggtttca
    12181 ttcattttta caattgtttt ctataatcga aaaagaagat actaactatg aaagaattac
    12241 acattatttg aacctgttac agcaaaattc tcaaaatttt ttagaacgtg agggtacagt
    12301 agactggtta ttaggttatg gaggtataat cccattatat attgatgtgt ataagaaaac
    12361 caaagataat caatatttag aaatcgctat ttttttgggt aacaaattga taatgtttgc
    12421 tgaaaaagat acaaatgtaa tgaaaaatat tggtataggt catggcattt caggcttact
    12481 tatatctatg gttgaactat ataaagttac caaagatagg caatatttag aatatattaa
    12541 aaaattaaat gaaagaatgt ctatttctct agttcaggaa aatgaagatg ttgtatcttg
    12601 gtgtaatgga atattaggtt atctattggg acaatcttac cttcacaaaa ataatattaa
    12661 gagtgcatta tctgataaag aaaaacaaag attactatta aaaattaaaa atcaatactt
    12721 ggaatctgac tgtttatgtc atggtaattg tgggataatt caattttata ttgatttgta
    12781 tttattagaa aactctgata aatatttgga acatgcaaaa aaaataggta acaaaatgat
    12841 ttctgaaatt attaaaaacg aatatataca aataagagag tttgaagggt ttgataatat
    12901 tggtttattt aatggcatat ctggtgttgc atataccttg gttaggctat tagaaccaga
    12961 gaatgttccg tcagtttttg tttaaaaata tgaattatga ggagattatt atgaaaaaaa
    13021 tactagcaat tatcggttca agagataaaa atagtgaaac tctaagcata gtaaatagaa
    13081 taaaagaaac ggttcaggat ttgaatgctt cttttgagtt tgaaattatt actccctatg
    13141 attataatct aaatttttcc gatagcccta gattagcgtt tataaaagga gcagatacaa
    13201 atgaacaaga tgaaagagat gattctaaaa aaataaaagc aaagatagaa aatgcttcac
    13261 ttgttattct agcgagtcca acttattttg ctaatgtatc tgcagatatt aaacttttca
    13321 ttgatcgttt ttgtcattta gcacatttgt tttattttgc aaaaaaacca tgtatcactg
    13381 tggtaacgtc agatggaaat ggtcatattc aaacttccaa ctatttgaaa tctttttgtg
    13441 atggattagg aatggttaga gtacaagaaa ttatatcaat aaggagtaat cctatttctg
    13501 agaatgaaat agaagcatct gtaagagaag gactaaagta tataagtaat cctcaaaaga
    13561 tttcacctaa tttaagtatg gagatgtcgt ttcaacactg gaaaaaatct atttcaaaac
    13621 agaatgaaac gttgtcagaa tataggtatt gggagaatag tgggttattt tcatgtaata
    13681 gtttagaaga atatttcgat agatataggt aaatactcat gaaaaatata aaagtagttt
    13741 atcaaaacga gcatagtgaa tgtggtatag cagtagtaac aagcatttta aacttttttg
    13801 gatctagagt tactataaat gatttacgtg ataaatatgg aagtcctaaa ggtggtttaa
    13861 cttttgggaa tatgaattat attatgaaaa aatttggttt aatatatcat ggaataaaaa
    13921 taaatgatac tgactatttg aaaaatcaaa aaaagccagt tattcttttt tgggataata
    13981 accattttgt agttttttat aaatataaaa gaggtcattt ctatgtaatg gatccaaaat
    14041 taggaaaagt tgtttacaca aaacacgaat ttgaagaaca tttctcctta tatgcgcttg
    14101 tgtttaaaga aattaattat aatgatggaa aaaaagaaat taaaataaat ttgaaaaaca
    14161 agaccaaaga gttaatttgt agtctattac gtagtacaaa atcgataatt atacttatga
    14221 tatttgtaat ttttttatct aagatgttat cattgatagt tcctgttttg actcaaaggt
    14281 taatagataa ttatcagata ttagcaaatt tgtctttagc tactttaata gggggaacga
    14341 ttttaatagc aggaatatat tacttgataa cagtctctta tagtttattg ttaacgaaat
    14401 tgcaacttag ctggagtaaa aaattatcta ataaatttat ggaaaaagtt tttataaagt
    14461 cgttaaattt ttttgtgaac agatcatcag gttcaatgat ttataaagct aatttaatca
    14521 ctatggttca gcaaatgctt tcaaaaaata caatcgaaaa tatcatagat tatttattta
    14581 tgattgtata tttcatttat ttaactaatt attcaagtaa attgacaata attactatca
    14641 tattttgttt attaatatta attaattccc taacatattc taaaataaat tataaaatca
    14701 atggaagagt tatagagtac caaagtgaaa ttcaatcctt gtatgttgaa atattttctg
    14761 gaatggaaac aataaaatcc ttaggaaaag agaaggtttt ttttacaagg tggtctaaca
    14821 tatttagtaa cagtttgaaa agtttgagtc aacaaggaaa agcagcagca tggttatccg
    14881 gaatttctac tacgctactt tttactttac ctattattat tctttttttt ggtatacatg
    14941 aagttcaggc gaaccaaatg tctttaggtc aactaattgg ttttacaacc ttgatagcat
    15001 attttattga accattttct acgatgattg gttctatttc tcaaatttta attttgaaat
    15061 catatcttaa ccaaatatca gacgtcacaa acacagattt ctataatgaa attaatggta
    15121 aaaagaagtt tgaaagattt gaaaatttaa aaatgaataa tgtaaacttt tctttttcag
    15181 aattcgaaaa gaatgtaatt tcaagtgtga atttagaaat aaaaaaagga gagaaagttg
    15241 caatagttgg taaaagtgga agtggaaaaa gtacactctt aaaactaatt tgtggattgt
    15301 ttattcctag tgaaggacag gttatttata ataatgaaga aatatctagt tttgataaaa
    15361 gtagtttgag aaataaagtt ggatatgtaa cacaaagttc aatagtattt ggtaatacgc
    15421 tagaggaaaa tttgatggta ggtgacgaat cgcctattgt tgttaaagaa gtattgactg
    15481 ctacaggaat aaacgaactg gtagataatg atatgctcgg attgaataca ataatatcag
    15541 aaaatggaat gaatctttct ggaggtcaaa aacagaagat ttccattgca agatgcttat
    15601 taaaaaatcc agatgtaatt attatggatg aaccgactag ctcattagat aatgtatcag
    15661 aaaaaaaaat aatggattat attttaaata attgtaaaac tagtgtgatt gtggcacata
    15721 ggttgaatac aataaaaaat atggatagga taattgtttt agataagggt agagttgtag
    15781 aggaaggtaa tcacgaacaa ttgttagaaa tgcaaaaagt atattattct ttatataatg
    15841 agatgtaatg cttgagatac tctttagagg atagggcaga taacagaata aatgctgttg
    15901 ctgcagtcta taaggatgaa agcaaagact tgattagaga aagtaataca catagatgtg
    15961 gcgtatgtgg agaagaaaaa acttgtacaa ctattttaga ctttgataat ttaattagaa
    16021 agaatatgct taatattaaa tatgattata aatttaatca atgtgtggca ttgtatgata
    16081 gaaaagaaga atttaatctt gttaaaagaa tgtagttttg ccaaagtaat catcgagttt
    16141 tattatgttc tttgctgtgc aattaattta ttttggttac gaacattagt aacgagtatt
    16201 taatataata tagtgaagct aatttactta aaagtttgat ataaattcca ataaacagtg
    16261 tttttcaact ctataaaatt caggaacagt caaccaaggc ttaaaaaagc agcaaacaaa
    16321 agaaaagtcc cttgtcaaac gttaattttg caagggattt ttgataggaa accatatcat
    16381 tttttatgaa aatcaagctc tttagcaact ggaagatgtt ggtttatagg cgctccccat
    16441 ccatatcatg ttggctcttt attcccactc gacaataaca actgttggac accacatgct
    16501 aatttctgta tgaatgtttc agaaatatat tttgttttat atcttgaaaa ttctataagc
    16561 tgcttcaaat aaacgtttta cagatttaga ggtaatcact atcactattt tctgtacaga
    16621 tgttccgggg tgctcctcct atgtgtacta acgatgtatt gaccgggccg tattttttta
    16681 gtataaagta tgaatggagg tagttatatg ttttgatcaa caacaacatt tagaattctt
    16741 gatgatgaaa ttgacttaaa aaccttacga aacgcaatgg aaatttccaa agagaaaaaa
    16801 gagattggta tttctcaaga gcaaatggag aagttgttga atagcgctat agaattggaa
    16861 actatcgaat actggctaat atttgtgatt ctaaagttgt gatacaaata ttttcaatag
    16921 gtcataaggg caccatttat aaagaataat ttattgtagt gacaaaaatc tgaaaacaaa
    16981 aaatagtatg aaaagaaagg ctataaactt ttaagttttg catataaacg aatctattta
    17041 acaaagtatt ctataaactt gaatgagtga agaaattaaa acatactaag attagagggt
    17101 aaattcaccc gtcgatgaat tcaccctcta atcttagtat gttttttttt tgtttgatta
    17161 attattacta atgtatttac tgtttgggtg ctcggtatcc tgctgcttct gcttcttcaa
    17221 cagtagagaa ccaagctact ggattcgtag ttctattata atatctactt ccaggtacat
    17281 gataaattcc attacgtgac cctttaatta aggcgttacc gcttggtgct tccgcagcag
    17341 ccgtctcgac ttccgcaggc gcctgtgcgg cttgttgcgc ctctgcttca gcttgcgctt
    17401 ttgctgccgc ttcggcttgt tctttttgcg ctttttcagc ggctagtttc tgagcttctg
    17461 cttcttttcg ttgtttttct ttgtgggcat ctaattgagt tttaacaacg gctacccgtt
    17521 ttgttaaagc ttgatttggg gagtttaaag cgtcaatttg tttgaccgct tcattatagt
    17581 aagcttcatt ggttggttct tgttcagctt tttcaacagc ggcagttgca ctggcgacta
    17641 attgttcatt tttttctttt tcagcgatag cggtttgaac agtcgttaat cgttgttgaa
    17701 atccttcttt accaactggg gcagcagcta ctaatttttc agctgcttga taatcgcttt
    17761 tacttttaga tttttcagca gttgtaactg cttcatcaac aggtactgct tctttgattt
    17821 tttcaaggcg atcattgtat tcctcgtatt cttgacttaa tgaagatact aaggttgcgg
    17881 cttcatcata gtttttctga gaaggttgtt tttcagcgta agctaaggct ttttctgttt
    17941 tggccaattc ttgttcagaa tctgtgatgc ttgcaataaa ttcttttgat ggtgtgactt
    18001 cgactgattt ttcaactttg gtatctttct tctcagccac aaaggtgatt ttttgcgttt
    18061 tttcatcgga cagttttact ttgtaagcaa acgttttgtc ttttgttttt acttccttgc
    18121 cattggccgt tagtttgctg ttgccgtcgt attcgccttt gatggtggct gagccattgg
    18181 catcggtttc aacactctct gcatcaagtg aaagcgttgg ggaagaatct gtcgtggcaa
    18241 ccccaccaat aaatagagcg gcacttgcta atgcggcata gccatattgt tttttcggtt
    18301 gtttcttgat taatgctttg atagtcagac ccccgctgac aagtaaccct aatagaccca
    18361 aaagtactaa tactacactc attcatttct ctcctttcga tataacgtta ttatacaatg
    18421 tattgtgaga aaatgaacat ttttttcgta ataattaata aatttcctga taaaaaaatt
    18481 atttcctgaa gctcaaattc ttttgtaaaa attttgttgt gctaaaatgg aaagtgagtt
    18541 taactacgta tgttattaga gaaggggaaa tcaatgaaag cagaaatcat tgcagtcgga
    18601 acagagttat tacttggaca agtagtgaat accaacgcca cctttttatc agaagagtta
    18661 gctgcgctag gcatcgatgt ttactatcag accgttgttg gcgataacgg cggccgctta
    18721 gaaacgctac taacagaagc agaacaaaga agtgatttaa ttgtcctttg tggagggcta
    18781 ggacctacag aagacgattt aaccaagcaa gttgtcgcac aacatcttca taaatcatta
    18841 gtagaagatc aagaaggatt gaaccgcttg caccagtttt tccaacagtc taagcggcca
    18901 atgacggaaa ataatctacg acaagtgtta gccattgaag gtggacaagt tcttcaaaac
    18961 ccgacaggat tagcggttgg ttctttcgta acagaaggca caacaagcta tttgctctta
    19021 ccagggccgc ccaatgaatt aattccgatg tttcaacaag cggcacgacc tttattgatt
    19081 gatgcgtttc cacaagaaga acaattgatt tcgagagtct tgcgttttta tggcattggt
    19141 gaatcacagc tggtgaccga gattcaatcg ttgattgcgc accaaacgaa tccaaccatt
    19201 gcgccttatg ctaagcctaa tgaagtgaca cttcgtttaa cagttaaaac aaaagactta
    19261 gtagccggcg aagaattatt aacagcgacg gaagaaaagg ttttagctaa agtgggagac
    19321 tatttttatg ggtatgggga tgacaatagt ttagccaagg taacagtgga tttgttatta
    19381 caaaacggac aaaccgtcac ggctgctgag agcctcactg ctggcctatt ccaaagtaca
    19441 ctgggggaaa ttgcgggtgc ttcgaagatt tttaagggag gcttcgtgac gtattcgcaa
    19501 gaaacaaaag agaacttttt aggaatttct catgaacttt tagaagaaca tggcacggta
    19561 agtgaagcgt gtgccaaaga aatggcagag aaagcgcgtc agttagctaa atctaactat
    19621 ggtttatcat ttactggggt cgctggtgac ccaatcgaag gtcaaccgac aggcactgtt
    19681 tggattgggc tggcggaaga aggccaacca accgttgcag aatgtttcca ttttaaccgt
    19741 gaccgaaatt atattagaca gagtgcggtt atgcgagggt tagatctttt gcggcgccga
    19801 atcattaata aaaaataaat atgcgaatgt ttgttcggct ttttcttgct tttttggtac
    19861 aaaagagata tgatagacct actaacagga aatgaaaaat aagtttatat aaattaaagg
    19921 aggattatcc attggcagat gatcgtaaag tggctttaga tgccgcactg aaaaaaattg
    19981 aaaagaactt tgggaaaggc tctattatga aattaggcga aaaagctgat caaaaaattt
    20041 caactatccc tagtggttct ttagcgttag atgttgcatt gggcgtaggt gggtatccac
    20101 gtggccgaat tattgaagta tatggtcctg agagttcagg taaaacaact gtttctttac
    20161 acgcaattgc agaagtgcaa cgaaatggtg gaacagccgc ttttatcgat gctgagcatg
    20221 cattggatcc tcaatatgcg gagaaactag gcgttaacat cgatgaatta cttttatctc
    20281 aaccagatac gggcgagcaa ggcttagaga ttgccgatgc cttagtttca agtggtgcga
    20341 ttgacattgt tgtcatcgac tcggttgctg cgttagttcc tcgtgcagag attgatggtg
    20401 agatgggagc gagccatgtc ggcttacaag ctcgactaat gtctcaagca ctacgtaaat
    20461 tatcaggctc aattaataag acaaaaacaa ttgctatttt cattaaccaa attcgtgaaa
    20521 aagttggcgt gatgttcgga aatcctgaaa caactcctgg tggacgtgca ttgaaattct
    20581 acgcaacggt tcgtctagaa gtccgtcgtg cagaacagtt aaaacaagga acagacatcg
    20641 tcggtaaccg cacaaaaatt aaagtcgtta aaaacaaagt ggcgccacca tttaaagtgg
    20701 cagaagttga tatcatgtat ggccaaggga tttcccaaga aggcgaatta ctagatatgg
    20761 ctgtggaaaa agaccttatc agcaaaagtg gtgcttggta tggctacaaa gaagaacgaa
    20821 ttggccaagg ccgtgaaaat gccaaacaat acatggcgga tcatcctgaa atgatggcag
    20881 aagtgtctaa attggtccgt gatgcatatg gcatcggtga cggttcaacc attacagaag
    20941 aagcagaagg tcaagaagaa ttacccttag atgaataaat aacgagtgaa tacgactcgt
    21001 taagaagaaa gacaacactt actgaacagg acaggtgttg tctttctttg tttagaacta
    21061 aattgttaaa tagactgttg tccatgtccg aacccatcca catcaagcag cttagtcaaa
    21121 cagcagacta tgcggcgttt gttctaaaat ttaaacaatt tgtgacggcg gaaacctaaa
    21181 aatgtgacgt tgtctaatat ttgctgccct ttccaaaaga aagggctttt ttaagttgac
    21241 acctttcgcg acaaacatta gaataaaatt gtgtgtatgc acaaatatgc aagtaggcat
    21301 attgataatt gattttagtt tatcaaaaaa ctacaagata tgaattaaca aaaagatagt
    21361 atggaggtgg aaatatggtt ttaaatattc tcctcgctat cgtcggtttg attgtcggtc
    21421 ttggtttagg atttgttatt gcaaagtcac gtcatgataa agcaataaat ggtgcaaaaa
    21481 tttcagcgtc gagtattctc gagaacgctc ggaaagaatc agaaacactg aaaaaagaag
    21541 cattgctaga agctaaggaa gagaaccaga agtatcgttc agaaattgaa agtgagttga
    21601 aagaaagcag attagaactt aaatctcaag aaaatcgttt aattcaacgg gaacaaacgt
    21661 tggatcgtaa agatgactct cttgaaaaac gtgaaggctc actggaagaa aaagaagaga
    21721 aacttggtgc tagacagcaa ttaattgatg agcgagaaaa agaagtagaa aacttaatta
    21781 atcagcaaca tcaagaatta gaacgaattg cttccctttc aaaagaagaa gcaaaatcga
    21841 ttattatgaa gtcaacagaa gaagagttga atcatgaact aaccttgatg gtcaaggagt
    21901 cagaacaacg tgccaaagaa gaatctgatc gcaaagcgaa gaacttgctt tccctagcaa
    21961 ttcaacgttg cgccgccgat tctgtttctg aaacaactgt ttccgtggtc actttaccaa
    22021 atgatgagat gaaaggtcgc attattggtc gtgaaggacg taatattcgt acattggaaa
    22081 cattaacagg gattgactta atcattgatg atacgccaga agcggttgtg ttatccggat
    22141 ttgatccaat cagacgagaa attgctcgaa tgaccttgga aaaattaatc caagatggtc
    22201 ggattcatcc cgctcgtatc gaagaaatgg tagaaaaatc acgtaaagaa atggatgaac
    22261 ggattcgtga atacggagaa caagcagcct ttgaagtagg tgctcatacg ttacatcctg
    22321 atttaattaa aattttaggc cgtttacgtt tcagaacaag ttatggtcaa aatgtcttga
    22381 accattcaat cgaagtagca aaactagctg gcgttttagc cgccgaatta ggcgaagatg
    22441 ttcaattagc caaacgtgca ggtttactac atgatattgg gaaagcattg gatcatgaaa
    22501 ttgaaggttc tcacgttgag attggcgcag aattagctgc gaaatataaa gaaaattcag
    22561 tagttattaa tgccattgcc tcgcatcatg gtgatgtgga agcaacctca gttatttctg
    22621 ttttagtggc agccgcagat gcgttatctg cagcccgtcc aggtgcacgt agtgaatcgt
    22681 tagaaaacta cattcgccgc ttagaaaact tagaaaatat ttctaatagt tttgaaggcg
    22741 ttgattcaag ttttgctgtt caagcaggac gtgaagttcg tgtcatggtg aaaccagaag
    22801 aaatttctga tttagaatct gttcgtttag ttcgagacat tcggaagaaa attgaagatg
    22861 acttggatta tccaggacat atcaaagtaa cggttatccg tgaaacacgt gccgtagact
    22921 atgcgaaata aaataaaaag cgaataagta tcgcgtgtag tgtctcaacg aacaattgca
    22981 aggat
//
