LOCUS       NZ_CP116604            26012 bp    DNA     circular CON 01-MAR-2024
DEFINITION  Streptococcus sp. HN38 chromosome, complete genome.
ACCESSION   NZ_CP116604
VERSION     NZ_CP116604.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus sp. HN38
  ORGANISM  Streptococcus sp. HN38
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2521977)
  AUTHORS   Yang,Q.
  TITLE     Integrative and conjugative elements can act as vectors for
            unconventional circularizable structure carrying optrA in
            streptococcus suis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2521977)
  AUTHORS   Yang,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2023) College of Veterinary Medicine, China
            Agricultural University, No. 2 Yuanmingyuan West Road, Beijing,
            Beijing 100193, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. Unicycler v.0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1.5x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/01/2024 01:35:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,496
            CDSs (total)                      :: 2,423
            Genes (coding)                    :: 2,347
            CDSs (with protein)               :: 2,347
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 27 of 76
            Pseudo Genes (incomplete)         :: 47 of 76
            Pseudo Genes (internal stop)      :: 23 of 76
            Pseudo Genes (multiple problems)  :: 20 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 985522
            Orig. end                         :: 1011534
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116604.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26012
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26012
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26012
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16012](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16012
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            302..2182
                     /locus_tag="PHA78_RS04865"
     CDS             302..2182
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768984.1"
                     /locus_tag="PHA78_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="WP_024378760.1"
                     /transl_table=11
                     /translation="MVVTKHFAVYSTKYRKSLIKYILNPEKTKKLKLVSDFGMSNYLDF
                     PSYEELVEMYQANLTNNDRLYDSRNDRQQLKQTKIHAHHLIQSFSPEDKLTPEEINRIG
                     YETIKELTGGNFRFIVTTHTDKNHIHNHILINSVDLNSDKKLRWDYAQERNLRMISDRL
                     AKESGAKIIPPNRYSHEKFETYRKTNHKFELKQRLYFLMENSKNFEDFVVKASALNVEM
                     DFSRKYARFFMTDRDMKQVIRGHQLYKRQPYTEDYFREHFATRAIEQRLDFLLPRVRNL
                     SHLLEIAEQLNLKISPKKKHVTFTLKEDDRTISIENKKVSTKHLYDVQFFEDYFDKRDI
                     TPEHDLANLVSDFEAYQEERDKDKLPIEELLAAYKDFKEKRDQVQEFEVALAEHQIDKL
                     VKDGLFVRINYGIKKDGLVFIPNRKLDIHESDQDKTYHVFIRETAQFFIYNKENSDLNR
                     YMRGRELIRQLTHDSKHIPKRRRPTMASLKEKIAELNLLIELDINNKSYQEVKDELIKD
                     IAQLDLTITELQDKVAHLNKVAEVLLNLNNSDPENRRLARYDYAKMNLTAAVKIEGVEK
                     EIETSQNELSKSIDEYEYLVRRLEKFVKILNCVKSIDANIEYYSRKIMKT"
     gene            2274..3638
                     /locus_tag="PHA78_RS04870"
     CDS             2274..3638
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719507.1"
                     /locus_tag="PHA78_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_024376477.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4e-37, bitscore:
                     125.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNLVLNIFLSSIILSFNNLPMQVKANENADVRYNILLKNPES
                     VDDIEMNFEKQGIKVTDKIPEINFLTVSTNKSIDEIRELNDSYIEEIVANNTLTVKPNI
                     TYLYGENVYTNNSFDFWSNQWDMQKSISTGTKFRHKSTGKATIGVIDSGITYDNPQIYS
                     NIISVKNFTADLDTGVVDEQNIIDKTGHATSVVGQISSNGEYKGIAPGMKIRMYRVFDE
                     GNAQDQWILKAIIQAAKDDVDVINLSLGEYLLENSTDEDDNTALVNIYQRAINYAYNQG
                     SVVVASVGDEGIDLDNQAELKDYLGSLNGKDYNQVDGFVRDIPAELDNIVTVGSVDDDD
                     YISSFSNRGSSVDIYATGGGTKALAEVGYENWVSKKLYEKDWVIVPTLEGKFTYAYGTS
                     IATPKVSAALGLIIEKYNLKDQPDEAIKILYDNSWLSKDDNNQEIRSLNITNFVQ"
     gene            3677..4360
                     /locus_tag="PHA78_RS04875"
     CDS             3677..4360
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677617.1"
                     /locus_tag="PHA78_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_017768982.1"
                     /transl_table=11
                     /translation="MYKILAVDDDFEILKLMRTILEMRNYEVTTYQEVKVPLSINDFKG
                     FDLILLDVMMPNIDGLQICKKIRDEVDTPIVFVSARDSENDIVSGLNLGGDDYITKPFS
                     VHQLVAKVAAHLKREERHKTSKEKESVVRELLPITFYLQEKQVCINGDIIPLTRREYDI
                     LELLSRKTNKVYTREDIYEQVYDDEADALFRSISEYIYQIRGKFSPYGINPIRTIRGMG
                     YKWYD"
     gene            4353..5705
                     /locus_tag="PHA78_RS04880"
     CDS             4353..5705
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="PHA78_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_024376476.1"
                     /transl_table=11
                     /translation="MTKKNYSIKQRSWKVVFEVIILTICNVVVILFLSAVLSELGLVTY
                     GTTGMDFPIQKEMTAEELSEVMKPYRYDFAIFSRMSEEVSQGHFVNNELHYYKSVIEKQ
                     KNLKVDLIHYEQFQTDDYFLVVRYSEVPEFSNQYFRKIPYNYLTITLFLLLFALSIIIC
                     LTRYIKEISANFRSIQNTSVQMGSRAFPLNDRYSQIDEFDAVLKTLHRKGNDLATLIEK
                     EKSEKKDFSFQVGALAHDIKTPLTVLKGNLELLEMTNLTEQQEDFISSMNHSINTFEKY
                     FNEMLSYSRLLIEDGESHKNIFLSEFLDDLLAEAEDIMVTKKVTFELTNSTSAKNFYGN
                     QLNLNRALINILANAARYANAEKKVILSVKDTADFLIFEVWNSGSAFTPEALSNANKLF
                     YTENFGRSSSHYGIGLSFAQKVAQKHEGRLVLTNPETGGAKVELYIKNKLL"
     gene            complement(5901..7180)
                     /locus_tag="PHA78_RS04885"
                     /pseudo=""
     CDS             complement(5901..7180)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002937360.1"
                     /locus_tag="PHA78_RS04885"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS4 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFDQIKSHLLNSIDDIVSDANQFVRQPAKDFSRNSPLTMKTMLKS
                     LLALGGKSLAKELLDLDLPSLSLLSFNDVIRLNSKHLKGILEILLLKSPLLTLCQS"
     gene            7448..8140
                     /locus_tag="PHA78_RS04890"
     CDS             7448..8140
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006532171.1"
                     /locus_tag="PHA78_RS04890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_017768979.1"
                     /transl_table=11
                     /translation="MQVKINNLSKNYGDRHVLKGVNFTIKAGSICGLLGVNGAGKSTLM
                     KIMFGLEKETSGEIFFDNRKRQVNEYNDRIGALIETPAIYMNLSAFDNLKTKALLYDIT
                     DDRIKEVLKKIGLENTGRKKAGKFSLGMKQRLGLGMAILTNPSLLILDEPTNGLDPDGI
                     KELLDLLKDLQRNGMTILISSHQLHEISKVADNIVILNEGYICYNELNNHDDNLEKIFF
                     NIVHGGLK"
     gene            8137..8856
                     /locus_tag="PHA78_RS04895"
     CDS             8137..8856
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768978.1"
                     /locus_tag="PHA78_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_024376473.1"
                     /transl_table=11
                     /translation="MKNIIRSEFLKINNNSYRKLLVALPLLAALIAFLLVGPQILESFT
                     IYWWEALFLFALVGLLFLKDFKSEEKAGQFQNVTLGKLGYKIRVSKMILVAVQVFFSSA
                     FLMLIIKVMESYLYPNYMEVNTLHDSITLLFMLLSVVWNIAFLYYLSDKLNPYLLVVGN
                     TFICLLIAPLIAQTKFWFIFPYTYHYKVAQTILHLRPSGDLEQSFGNLNHSIVLLCVLL
                     SAMLTLIICMLMYRKKE"
     gene            8859..9527
                     /locus_tag="PHA78_RS04900"
     CDS             8859..9527
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_050571415.1"
                     /transl_table=11
                     /translation="MKIIQSEWLKIKMSYPSYLILGFSLIEIITILPYLIFVKSSKALE
                     AAIFFPMLVIAVIISLVAILICEQEEQANHFQILISEREGAKLWAAKIIILDLMLLLPT
                     IGVWSLLYLVFKQDSYLTVGLIYWLLSAFLNHFHLLLAFLLGNSGNLIVAFIECLLIIF
                     ATNKVFLEMHWLPIALPINMILEPVDGYLVNLSIFISWIVLLFLAQIYLLKYSKIKILK
                     "
     gene            9652..9816
                     /locus_tag="PHA78_RS04905"
     CDS             9652..9816
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="PHA78_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_079267797.1"
                     /sec_met_domain="TIGR03731 (E-value: 7.2e-15, bitscore:
                     51.9, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNNDFNLDLVSTSKEKKQGASPRITSISLCTAGCITGRIMGCHK
                     TPTVSCNCH"
     CDS_motif       9652..9723
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MQNNDFNLDLVSTSKEKKQGASPR"
                     /locus_tag="PHA78_RS04905_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9724..9816
                     /prepeptide="core"
                     /locus_tag="PHA78_RS04905_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="21.80"
                     /molecular_weight="2964.5"
                     /monoisotopic_mass="2962.4"
                     /core_sequence="ITSISLCTAGCITGRIMGCHKTPTVSCNCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQNNDFNLDLVSTSKEKKQGASPR"
                     /leader_location="[9651:9723](+)"
                     /alternative_weights="2982.5"
                     /alternative_weights="3000.6"
                     /alternative_weights="3018.6"
     gene            10001..12994
                     /locus_tag="PHA78_RS04910"
     CDS             10001..12994
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="PHA78_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_099779888.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.6e-82, bitscore:
                     274.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.5e-19,
                     bitscore: 67.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.2e-25, bitscore:
                     85.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNDKYFKTDSYLIRSSILETQTKNFVNNIDFLEHLKNDQMFLEQ
                     LFFANSSLYYQLLKYYQGNISNTKKVDKIAISVYRYYKRSHGRPTPLGLFSETSIGTFQ
                     ENNHMKLNENVNKIITLDAEWLMLLVYKFESEYYNSLSFTINNACYKKGDRIYQLYSLI
                     EDQEKISIRETSVYKIISKNCSRGYCNYRKLIEELVSVYGIESSNLAEDYILTLIKNHY
                     LLSDIQKDILCGSPREKLLDFISRNYIDIHIKTSLRNIFEMIDLYSKLPIGEGVALLEK
                     IYETMSSIVRSKSYLKIDLISNYSEFSFSTQIQEKFERFANFIALSTESTNKTHLDYYS
                     EAFLEKYGLEREVKLVELLDPCIGLGAPFGYNHPSNDFIMEEPPFEFYSEAEEQMYLDL
                     YTKAVSERRPIELSSIVNHYEKINSEKLSNIDGFDLFFNMVKKDGKTIFSLSNIIGSNT
                     LGGGSGRFAGLSGTLQNFHEKLLQHEDRIGDLDNISTCEILFLPENLRHRNIMNTVSNR
                     NFCLPISTDVSGKKILLEDIYIGLSSDLKFYARDIRSGEFIRFYSTNMYNLTLFCNELR
                     FLVEISIKNNIGKIPWEIIYKNFSYVPRLTFEDIIIAPAKWRVRVNDTMNSVNQIVKKY
                     GLPQTFYIEEGDSRILINLTKQLDYNSFENLLSSSFQNKTQLILTEVIGDDSPVVRNGK
                     STSSDLVIPFRNTNYLSNCSHGYKKIVETQDFELMDRERRQLPFQEWTYFKIYISEDRQ
                     DEFLIGYLTRLKNHILENEGKVFYLRYRDPKPHIRLRISGLSENIELYYSVLSIINEAI
                     KNCIVSTFSIDIYERELERYGGSLLMREIEDIFCVDSQICIEMINSSKLDSELSILDYA
                     VLVNYIYLKTLFIRDDSIIEFLEDVSPSNRSKNLNKTKHHYINMIKNYILKNNLQSNFP
                     IITELSILLHSIQFKINKFEKFRKTSIVDSIIHVHNNRLIGIDREQEKEIYNILRLVFQ
                     NEKFTKDK"
     aSDomain        10430..10687
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PHA78_RS04910_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.90E-21"
                     /identifier="RREFam001.1"
                     /label="PHA78_RS04910"
                     /locus_tag="PHA78_RS04910"
                     /protein_end="229"
                     /protein_start="143"
                     /score="67.0"
                     /tool="antismash"
                     /translation="TINNACYKKGDRIYQLYSLIEDQEKISIRETSVYKIISKNCSRGY
                     CNYRKLIEELVSVYGIESSNLAEDYILTLIKNHYLLSDIQK"
     gene            12996..14774
                     /locus_tag="PHA78_RS04915"
     CDS             12996..14774
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="PHA78_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_225585635.1"
                     /transl_table=11
                     /translation="MDKITSKQLLSTVFTIPNTLKLIFRLEKKYATYLIVINVLIALFP
                     LGIFYVYQELINAILLQSNKVLQTLVIYFIVQSVSSIFVQINAFFLEKFNLNLSYSLSK
                     KLITKTSSLELADFENADTYNLVENLTQDSTYKPYQLFNAIISFFSSIISLLVCLFYIS
                     TWKTSIALFLLCIPLISLVTFLKIGQLEFLIQWNRVGAERKVWYYIYLLTHDFSFKEIK
                     LNNISDYLINKFSLIKEEFISQDSEISKKKNIFNAILDILLNFINCLVIIMLISAVRAG
                     EILLGNLISLIQALTRINTYSQSMIQSVYIIYNTSLFMEQLFNFFESEQYDQSNIYINN
                     TDISLKEVSEINLVDVSYCYPNSSINALSEISLSFKCGELVAIVGKNGSGKSTLVKLLC
                     GLYKPSQGEIVFNGISNKNLDLAFYQKHVSVLFQDFVKYELTLRENIALSNLEILNDTQ
                     AIKLALKKFSFEVDRDIDMQLGTWFQDGRQLSGGQWQKLALVRTFLKNASVYILDEPSS
                     ALDPVSEKEIFDKFIELSRDHVSIFISHNLKSAKKADKIIVMKDGKVDGVGNHETLLRT
                     NEHYKKMYYSEQYEEL"
     misc_feature    13020..13038
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 28.3"
                     /tool="antismash"
     gene            14771..16012
                     /locus_tag="PHA78_RS04920"
     CDS             14771..16012
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="PHA78_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_050572115.1"
                     /sec_met_domain="LANC_like (E-value: 3e-54, bitscore:
                     181.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKMDELLEDVSKITIAEYDFELDNIINSNNNYDVVTLSRGLPGY
                     ILLVSELNSNHVSSYEEKLTSYIEILVSILSERGVMTGSLYSGAAGIGISLLHLNENKY
                     KRLVESLDEYIEYFVSEFLPSIDTGNMSPTDYDIIEGVSGILVYISLHDRERLKDVQRK
                     IVNFLTSSFKEDIWNDIFYVTSQNQMSESESVLFPKGCLNLGVAHGLAGVGIALAYTMI
                     KGNFSCQIEETLRHIIDVYEQFETPSLYTWKDGLDIDELKQGYSNSKFLPNIDAWCYGS
                     PGISLLYMYCGVALNDEYLKNKAVEILKTSMERQAGIDSPILCHGYAGLLEICQFFKYV
                     YQTDEFDKYIYDFDKKITQYLQSKRNNELQIISQFGYLNGDVGVLLSMLHIYSKNVNTY
                     WQAGLLLFKDIIFE"
     gene            <16119..16394
                     /locus_tag="PHA78_RS04925"
                     /pseudo=""
     CDS             <16119..16394
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01168.1"
                     /locus_tag="PHA78_RS04925"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif.; incomplete; partial in the middle
                     of a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="YSIRK-type signal peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="FSVRKYSIGVTSVLLVVCLFGATQKSVSADEIAAAIAFQEVIVNQ
                     NTASGNEIAEEFSQMDDVPLENEKINDSLEDVKTNIDVSNGKIAYS"
     gene            16445..16669
                     /locus_tag="PHA78_RS04930"
     CDS             16445..16669
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS04930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_024375789.1"
                     /transl_table=11
                     /translation="MHTESVTATSPESSKAEPADEELSKQSAITEDLNDTIPVEVVKQA
                     TNEVKSSKDGGFLMTIWLQLKTSLSKIMI"
     gene            16627..16863
                     /locus_tag="PHA78_RS04935"
     CDS             16627..16863
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS04935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_142350595.1"
                     /transl_table=11
                     /translation="MVAIEDFLEQNNDLKLSKGATSRAGKVIGDDYPASWKKRPDEFDT
                     WGYNKSTCTSFVAHRLHSVNKFEVPRAMGDAGQ"
     gene            <16909..>16995
                     /locus_tag="PHA78_RS12475"
                     /pseudo=""
     CDS             16909..>16995
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017102.4"
                     /locus_tag="PHA78_RS12475"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVGSVAWTTNGTFGHVSWVASVSGNTVTV"
     gene            17152..17511
                     /locus_tag="PHA78_RS04940"
     CDS             17152..17511
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020049.4"
                     /locus_tag="PHA78_RS04940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SH3 domain-containing protein"
                     /protein_id="WP_017768970.1"
                     /transl_table=11
                     /translation="MLLQPGTYRFTSRKGIKSEPKIYSTDIAYYDSGDTVNYDKTLVAD
                     NHEWISYVSYSGARRYIAINQLAKPVSPVVKGTTNIQNKNDQLGTFDVVISNVSGRQWI
                     SYIAYSGNRRYIAIS"
     gene            17648..17869
                     /locus_tag="PHA78_RS04945"
     CDS             17648..17869
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011922422.1"
                     /locus_tag="PHA78_RS04945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_017768969.1"
                     /transl_table=11
                     /translation="MYRRVKDLREDKDYSQDYLAKYLSCSQSAYSRLENGKRQLSIEYL
                     IKLSTLYHVSTDYLLGLTDYPYRLHHKK"
     misc_feature    17951..17966
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.26"
                     /tool="antismash"
     gene            18142..18282
                     /locus_tag="PHA78_RS04950"
     CDS             18142..18282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003069254.1"
                     /locus_tag="PHA78_RS04950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017768968.1"
                     /transl_table=11
                     /translation="MTKIIIGEDTSQVVIEGYKVTVKVTDKPLSLTDILDDLLGRKLEK
                     I"
     gene            18381..19955
                     /locus_tag="PHA78_RS04955"
     CDS             18381..19955
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158591.1"
                     /locus_tag="PHA78_RS04955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_024375788.1"
                     /transl_table=11
                     /translation="MTQTCIYLRLSRDDGDNIESNSIVNQRSLLRDYAQKHDLIILEEF
                     VDDGISGLTFNRPDFNRMMTMVNEKRIDTIIVKDLSRFGRDYIETGKYIQRIFPSIGVR
                     FISVNDHYDSLTADTNETHLVLPIKSLINDSYCRDISMKVRSTQKAKRQNGEFIGAFAP
                     YGYRKDDNVRNHLVVDESARSIIEKIFTLKLEGYSSNRIATYLNKAGIATPLQYKKSCH
                     ENFKGFYGNSNQWNAKMVNRILVNRVYTGTLEQGKHTKLNYKSKQSLKVSPDDWVRVEN
                     THEGIVSESTFEIANSLLLRDVKNGKGQPSLFTGLLFCKDCQSQMIQRKVRYKKIETIQ
                     YICSTYNKGKGCSRHSIKDDSLLEVISTLIAQHLEWKSYLIERIPHYLSQEPFLEIDFT
                     GLVTERKKYELLIQSLYMDLDDGLINELEYQEFQRHYRQKLKQVEETIALKKELAQELY
                     HKLQDREAWLKQLSELRDTDCLNRLTLVSLLDRINIGEDHEITLVFHDIKEMDILQQFS
                     QSETEAV"
     gene            19955..21571
                     /locus_tag="PHA78_RS04960"
     CDS             19955..21571
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768966.1"
                     /locus_tag="PHA78_RS04960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_024375787.1"
                     /transl_table=11
                     /translation="MARTKNRYRTEETKTTQVTIYRTGIYIRLSKERTETWRNKSQSLE
                     TQESLARTFAKDKGLMVVKAYTDYEYSGTKFNRPAFQEMMEDIKKGHINCILIRDLSRL
                     GRDYIEMGRLIDKVFPFLGVRFISINDNLDTLNGLEEKKSFEVEIKNLVNDLYSKDISK
                     KVTASHIYHASRGYYIGSFAPYGYQLDKQEHGVKLMIDPLVKPILRIAFDILVQGKSIS
                     KVTAYLNKARVAVPTVYRRTGQLYRSEDDRTEWRNSTILRLIQSPVYQGHLVQRKSNKT
                     LTETDYIRFEYAHEAYITREEYDKIVTYLHSRRSIKKRLQPKRPNRYKGLIYAQGNSKQ
                     MYRYCRHFSNQKSDYDYYYFTDHVYDPQISEKQTVYISEIALDRIISELLQAEIERLGI
                     AEQLLSKLKTKKDDCIKVYYRQVRQHQQAILRLLEEISDLYASYSLVRTEKATYLTQKS
                     EKEAQIETLSQEIRHCEVAIGQLEEEHQKQISWVKSLTQCQGTETLTSELLQAIIERIE
                     VDVNKQVTITFRCQLGGAVNV"
     gene            21564..23000
                     /locus_tag="PHA78_RS04965"
     CDS             21564..23000
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041341.1"
                     /locus_tag="PHA78_RS04965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_099806522.1"
                     /transl_table=11
                     /translation="MSKVALYLRLSVDEAGTDESISIVNQRYLLHHYLDNSSDFQNFQR
                     EEFVDDGFSGTTVNRPAFQRLMTKVKSGEIRHVIVKDLSRFMRDYLELGNYLENIFPFL
                     GVRFIALNDQYDSLTSENNGVEIDVPFKNLLNEFYAKDVSEKIKSAMNSMKRSGKNMSW
                     LPPFGYLKDPEDRFKIIIDETVAPIVRRIFALYLDGNSYQTIARLLNEEQVITPAERKM
                     QISQARYAKSLRLTTEQKRNVWSSTTVGQILKNEAHKGTYLFNTRTYVRGKHVFRPKSE
                     WERIENNHEAIISSELFEQVVQLKGSKATKRKQHQIPKTSSVLTGLIRCEHCDHSLIGH
                     YNHQGYQYFSCRYCKGQGEKMKSCRVDRIEQAIKGKLGDEAVKPHQKVSKTLVLREIER
                     LKTEKLACFQDYKDSLLTREDYIAKKKEVDKSVQALEEQMKEANCVQLPTDKKLSKEIV
                     VAHVDKVVVDCLGFFTVIYK"
     gene            <23110..23454
                     /locus_tag="PHA78_RS04970"
                     /pseudo=""
     CDS             <23110..23454
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012028182.1"
                     /locus_tag="PHA78_RS04970"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="8-oxo-dGTP diphosphatase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GHIEEGENFHDSVVREVQEETGLTVTDARLVGLKHWPDKEGHRYI
                     VFLYKATEFTGTIRSTEEGEVRWVEKSDLPQMDLAYDLLEILKVMDEPDLSEFFYTRKN
                     DDGEWDINFR"
     gene            23648..24463
                     /locus_tag="PHA78_RS04975"
     CDS             23648..24463
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018364850.1"
                     /locus_tag="PHA78_RS04975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_306537715.1"
                     /transl_table=11
                     /translation="MMMKKYIMTGLVLLATMTLSACSGNATQEDTSLKDVQEKGKLIVA
                     LNPEFPPFEFRTLVDGKDTIVGADIELAKSIGQELGVEVEFSAMSFDNVLNNVQSGQSD
                     IAISGISATEERAKVYDFSIPYYTSTNKVIINKEDLAQYTSLDSLAEANIGAQKGSIQE
                     QIVKEQLPSSTVIALASNGELINQLKSQKLEAVIFEEPIAKAYVAKNDDLVILDTEIKS
                     SYSDAYAIALPKGSTALKEKVDSVITKLVESGQMDQFVQEAYELSIANN"
     gene            24635..25435
                     /locus_tag="PHA78_RS04980"
     CDS             24635..25435
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014735814.1"
                     /locus_tag="PHA78_RS04980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_024394614.1"
                     /transl_table=11
                     /translation="MKKILALAATVLAGLTLAACSSTSSQSALDKIKEKGTLVVATSPD
                     YAPFEFQALVDGKNEVVGADIMLAQKIADELGVKLEVSAMSFDNVLSSVQNGKADIAIA
                     GLSYSEERAKVFDFSESYYQISDVLLIKKDSANSLTSIDAMSGKTLAVQKGSTQESYAQ
                     ENISQANIISLTLMGEAVNELKSGKVDAILMDSPVAAGYVSQNSDLAVASVEFPTIDEN
                     SKVIALPKGSTELKTAIDKVIAEVKASGEFDTFLEKAATYTSVE"
     misc_feature    complement(25830..25845)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.44"
                     /tool="antismash"
ORIGIN
        1 gagttggaaa ccctgaacaa ccgtatcggt cagagtggct gtaaaaattt ctctgcttat
       61 gctagaaaag ttctgctcaa tcccaacatg acctttctga ccattgacac cagtaactat
      121 gacgacttgg tatttgagtt gagacgaatc ggaaacaacc tcaatcaaat cgcacggacc
      181 gtcaaccaga ctcacatctt aacaccaagc gaccgtggat ttttggtgca aggcattggc
      241 caactcataa aggaagtgga gaaggacttt aacataaagt gtcagcagct gaaggagttt
      301 tatggtcgtc actaaacact ttgcggtgta tagcaccaag tatcgtaaga gcctcatcaa
      361 gtatattctc aatccagaaa agacgaagaa gctgaaactg gtctctgatt ttggcatgag
      421 caattacttg gactttccca gctatgagga attggtggag atgtatcagg caaacttgac
      481 caacaatgat cggctctatg attccagaaa cgaccgccag caactcaagc agaccaaaat
      541 ccatgcacac cacttgattc aatcattttc tcctgaagac aagctgacac cagaggaaat
      601 caatcgcatt ggttacgaga ctatcaagga gttgacaggg ggcaactttc gtttcatcgt
      661 cacgactcac acagacaaga atcatatcca taatcatatc ctgataaact ctgttgacct
      721 aaactctgac aagaagctca gatgggacta tgcccaggag agaaatcttc gcatgatttc
      781 tgaccgcttg gcgaaggagt caggggcaaa gattattccg cccaatcgct attcgcatga
      841 gaagtttgaa acctaccgca agaccaatca caagtttgaa ctcaagcagc gtctctattt
      901 tctcatggag aacagcaaga actttgagga ctttgtggtc aaggcttccg ctctcaacgt
      961 ggagatggat ttctctcgca agtacgccag atttttcatg accgaccgag acatgaagca
     1021 ggtcattcgc ggccatcagc tgtataagcg ccagccctac accgaggatt atttcagaga
     1081 gcattttgcg acacgagcta ttgagcagcg actggatttt ctcttgccca gagtacgaaa
     1141 cctctctcat cttttggaaa tagcagagca gttaaacctg aaaatctccc cgaagaaaaa
     1201 gcatgttacc tttaccttga aagaggacga ccgaacaatt tccattgaga acaaaaaggt
     1261 cagcacaaaa cacctctacg atgtccagtt ttttgaggac tattttgata aaagagacat
     1321 cacaccagaa catgacttgg ctaacctggt ctcagacttt gaagcctacc aagaagagcg
     1381 ggacaaggac aagctcccaa ttgaggaact cttggcggcc tataaggatt tcaaagaaaa
     1441 acgagaccag gtccaggagt ttgaagttgc attagcggag caccagattg acaagttagt
     1501 taaagacggt ctctttgtca gaatcaatta tggtatcaaa aaagacggct tggtctttat
     1561 accaaaccgc aaattggata ttcatgagag tgatcaggac aagacctacc atgtctttat
     1621 ccgagagacc gcccagtttt tcatttacaa taaagagaac tctgacctca accgctacat
     1681 gcgaggacgg gagttaatcc gccaactcac tcacgacagc aagcatatcc ctaaacgcag
     1741 acgcccgact atggccagtc tcaaagagaa aatagcagag cttaatcttc ttattgaatt
     1801 agacatcaac aacaaatctt accaggaagt caaagatgag ttaatcaagg acatcgccca
     1861 gctggatttg accattacgg agttgcagga taaggtcgct catctcaaca aagtagcaga
     1921 agtcctgctc aatcttaata actctgaccc agaaaacaga cggctagcca ggtatgatta
     1981 tgccaagatg aatctgactg cggctgtaaa aatagaaggg gttgagaaag aaattgaaac
     2041 ttctcaaaat gaactcagta aatccataga tgagtatgaa tatctagtga gaaggttgga
     2101 aaagtttgtt aaaatcttaa attgtgtaaa gtcaatcgat gctaatatag agtattactc
     2161 tagaaaaatt atgaaaacat agaaaaattc aaataaaatg tgtaataatt attctgaaga
     2221 aattctgaaa tacagttggt ataatatagt cgaaaaatat agaggttata atcatgaaaa
     2281 aaagaaattt agtattaaac atttttttgt cgtcaattat tctttcattt aataatttac
     2341 caatgcaagt gaaagctaat gaaaatgcag acgttaggta taatattcta ctaaaaaatc
     2401 ctgagtcggt tgatgatatt gaaatgaatt ttgaaaaaca aggaatcaag gttacagata
     2461 aaattcctga aataaacttt ttaactgtat ctactaataa aagtattgat gaaattagag
     2521 aactaaacga ttcgtatatt gaagaaattg tggctaataa tacgttaact gtaaaaccta
     2581 atataaccta tttatatggt gaaaatgttt atacaaataa tagctttgat ttctggtcaa
     2641 atcagtggga tatgcaaaaa agtatcagta cggggaccaa atttagacat aaatcaactg
     2701 gcaaggcaac aattggagtc atagactcag gtattacata tgataatcca caaatttatt
     2761 caaatattat ttcagtaaaa aactttacag cagatttaga tacgggtgta gttgatgagc
     2821 aaaatatcat cgataaaaca ggacatgcaa cgtcagttgt tggacaaatt tcatcaaatg
     2881 gtgaatataa aggcattgct ccaggaatga aaataaggat gtatcgtgta tttgatgagg
     2941 gaaacgctca agatcaatgg atattaaaag caattattca agcagcaaaa gatgatgttg
     3001 atgtcattaa tttaagttta ggagagtatc tgttagaaaa ctcaactgat gaagatgaca
     3061 atactgcctt agttaacatt tatcaaagag caatcaatta tgcttataat caaggttcgg
     3121 ttgttgttgc ctctgttgga gatgagggga ttgatttaga taatcaagct gaattgaaag
     3181 attatctagg aagtctaaat ggcaaagact ataatcaggt agacggtttt gtgagagata
     3241 tcccagcgga attagataac attgttacag ttggttccgt agatgatgat gattatattt
     3301 ccagtttttc aaataggggt agcagtgtag atatttatgc tactggaggt ggaactaagg
     3361 cattagcaga agttggttat gaaaactggg ttagtaaaaa gttatatgag aaagattggg
     3421 taattgttcc tacattagaa gggaaattca cttatgctta tgggacctct attgctactc
     3481 ctaaagtatc tgcggcatta ggactgatta ttgaaaagta taacttaaaa gatcaaccag
     3541 atgaagcaat taaaattcta tatgataata gctggttaag taaagatgac aataatcaag
     3601 aaattagatc gctgaatatt acgaattttg tgcaataata gtgtaaaata gaaatataat
     3661 attttgaggt atcaggatgt ataagatatt agctgtagat gatgattttg aaattttgaa
     3721 actgatgaga actattttag agatgagaaa ttatgaggta acaacctacc aagaggttaa
     3781 agttcctctt tctattaatg attttaaagg ttttgattta atacttcttg atgtcatgat
     3841 gcctaatatt gacggactac agatttgtaa aaaaattcgt gatgaagtag atacaccaat
     3901 tgtcttcgta agcgctagag atagtgaaaa tgatattgta tcaggtttaa atttaggcgg
     3961 agatgattat attactaaac cgtttagtgt ccatcaatta gtagcaaagg tcgctgctca
     4021 tctaaagaga gaggagaggc acaagacttc taaagagaaa gaaagcgttg ttagagaatt
     4081 gctccccatc actttctatc ttcaggaaaa acaagtttgt attaatggag acattatacc
     4141 tcttactcga agagagtatg atattttaga attgttatca cgtaaaacca ataaagttta
     4201 cacaagggaa gatatttatg agcaagtata tgatgacgag gctgatgcat tgtttaggtc
     4261 tatttctgaa tatatatatc aaataagagg gaaattttcg ccatatggaa ttaatccgat
     4321 tcgtacaata agaggcatgg gatacaagtg gtatgactaa aaagaactat tcgataaagc
     4381 agagaagttg gaaagttgtt tttgaagtta ttattttgac aatttgtaat gtagtagtga
     4441 ttttattttt atcagctgtg ctttccgagt taggtcttgt gacatatgga acgacaggaa
     4501 tggacttccc tatacagaaa gagatgacgg ctgaggaact tagtgaggtt atgaagcctt
     4561 atagatatga ctttgctatt tttagtagaa tgtcagaaga ggtcagtcaa ggtcatttcg
     4621 tcaataatga attgcattac tataaatcag tgatagaaaa gcagaaaaat ctcaaagtag
     4681 atttgataca ttatgaacag tttcaaactg acgattattt tttagttgtc agatatagtg
     4741 aagtcccaga attttcaaat caatatttta gaaaaattcc ctataattac ctgactataa
     4801 ctttatttct cttacttttt gctctgtcaa ttattatttg tttaacgaga tacataaaag
     4861 agatttctgc aaattttaga tctattcaga atacgtctgt ccagatggga agtagagctt
     4921 tcccgctcaa tgatagatat tctcaaattg atgagtttga tgctgtttta aagactcttc
     4981 atagaaaggg caatgattta gcgacactta ttgaaaaaga aaaatcggag aagaaagatt
     5041 tttctttcca agttggtgct ctagctcatg atatcaaaac gccactaact gtattaaagg
     5101 gaaatctcga gttacttgaa atgactaatt tgacagagca acaagaagat tttatctctt
     5161 cgatgaacca tagcattaat acttttgaaa agtattttaa tgagatgtta agctattcga
     5221 gacttttaat tgaagatgga gaatctcata aaaatatttt tttatcagaa tttttagatg
     5281 atttattggc cgaagctgag gatattatgg ttaccaaaaa ggtgacgttc gaacttacta
     5341 attcgacatc agctaagaat ttttatggga atcaacttaa tttgaataga gcattaatta
     5401 atattttggc aaatgcagca cgttacgcta acgctgaaaa aaaggttata ttatcagtaa
     5461 aagatacagc agattttctt atttttgaag tttggaatag cggttcagca ttcacaccag
     5521 aggctcttag taacgctaat aaattatttt acactgaaaa ttttggtcga agtagtagtc
     5581 attatggaat tggattatca tttgcccaga aagttgccca aaaacatgaa ggaagattag
     5641 ttttgacaaa tcctgaaact ggaggagcaa aagtggaatt gtatattaag aacaaactct
     5701 tatgaagtaa aaattgaatt ttattatatc ataggaataa aggatagcat tcaaggagtc
     5761 aatgtcatta agttaacctc atccttcatc aaacaaccta ttcctacact cgtatattag
     5821 tgcatattct gggataggtt gtgcttttta tcgcattttg gccgcacaaa aggaaagttt
     5881 tttcccccat ttttcattaa ttatggaact ctataagtga aacttactgg actttggctt
     5941 tttatcattc ttggaaatgt tcgattgggt cgaacaatgg ataaatgctt ggctatgtag
     6001 gtgttcaatt tggaggaagc aagtatacct ctgagaaatt tttgacaggc ataaacagcg
     6061 tctgaaaagt tgattttata agcttttttc gcctttgatt gtttaatggt aacatgtgag
     6121 atgagccatt tacaaaagtt aacattgata aaacgtgcat agatttcttg gagaatccct
     6181 tccttctttt tggcatgaaa atgagtcaac cccacactgt atttaaggtc acgaaaactg
     6241 gtctctatgc tccagctgct ggcatagagg tcttttaatt tttccacggg attatctgta
     6301 tttgtaacta aggtttcata gcaaccaggt tggatttcca gtcgtaccat acgaaatgtt
     6361 agctcataaa agctgatggg ttccgctttt cgactagagc tcggtaagaa atcaaaaggg
     6421 tagtgatgcg ttaaatagtg atattggttg ggaaagtctc gatagttttg cttcatctcc
     6481 tgggtttgtt tccgacagag tttgaggttg aaatgttcat caaaacaagg cgtgtcaggc
     6541 aggttcaaac ctgatttgat ggaggcattt ccatcccgaa ttcggatgac atacaaccaa
     6601 tttttctctt ggcaatggac catgacattg taagattcat agcctctatc cacgatgaca
     6661 agtgctcgtg cgaaagggag aattctccat catgtcaatg attcatcatt atcgaccttg
     6721 tcttgaatcc gcaggtcacg ataaacagcg ttttctaaat cgtaaagtgc attgatatga
     6781 gtcaaattgt aaggcgtacg atttgccccc gtttggatac aggtcgtctt atcaaagcga
     6841 tttctaggca aaatgacatc actgccatcc acagctaaga ttggcatagg gttaacagtg
     6901 gggattttag cagtaaaatc tctaaaatgc ctttcaaatg cttggaattt aatctgataa
     6961 cgtcgttgaa cgaaagcaga ctgagagacg gcaagtccag atccagcagt tctttagcta
     7021 aactcttgcc acccaaggca aggagagatt tcaacatcgt tttcatggtc aatgggctgt
     7081 ttcgactgaa atcttttgct ggttgacgga caaactggtt ggcatctgaa acgatgtcat
     7141 caatactatt aagcaaatga cttttaattt ggtcaaacat gattttctcc ttttattttt
     7201 agtctaacat agaaaaaaat cccctgccac tcaaaatttg gagtagtagg ggatttaact
     7261 taatgacatt gttcaaggag tgactatctt tttttatatg attttgagat agttgctcta
     7321 actgaaaacg ccttaggaga tttcttccta taagaaaaat gactcgtttt cataaaagtt
     7381 ttgactctga acaaaatctg aacaagaagt aatatgatgt ttgtataaag taaggaggaa
     7441 actatttatg caagtaaaaa tcaataatct atccaaaaat tatggagata gacatgtact
     7501 aaagggtgtt aatttcacaa ttaaagctgg cagtatctgt ggcttattag gtgtgaatgg
     7561 agcaggaaaa tcaacactaa tgaaaattat gtttggttta gagaaggaaa caagtggaga
     7621 gatctttttt gataatcgta aacgtcaagt aaatgaatat aatgatagaa taggagcttt
     7681 aatagaaaca cctgctatct atatgaatct ttcagcattt gataatttaa aaaccaaagc
     7741 attgctgtat gatattacag atgatcgaat taaagaagtt ttaaaaaaga ttgggctaga
     7801 aaatactgga agaaagaaag caggtaagtt ttctttagga atgaagcaac gcttgggctt
     7861 aggaatggct attttgacga acccgagttt acttattctt gatgaaccaa caaatgggtt
     7921 agatccagat ggaattaagg aactattaga tttattgaag gatttgcaga ggaatgggat
     7981 gacaattctt atctcaagtc atcaattgca tgaaatcagt aaggtggctg ataatattgt
     8041 aatcttaaat gagggctata tttgctataa cgaattaaat aatcacgatg ataacttaga
     8101 aaagattttc tttaacattg ttcatggagg tttgaaatga aaaatattat ccgatcagag
     8161 tttttgaaaa taaataataa tagttatagg aaactattgg tagccctccc cttgttagca
     8221 gcattgattg ctttcttatt agttggacca cagattttag aaagttttac aatttattgg
     8281 tgggaggcac tatttctctt tgctttagtg gggttacttt ttcttaagga ttttaaaagc
     8341 gaagagaagg caggtcaatt tcaaaatgtt actttaggaa aattaggata taaaattcgg
     8401 gtatctaaaa tgattttagt agcagttcaa gtcttttttt caagtgcatt cttgatgctt
     8461 atcataaaag taatggaaag ctatttatat ccgaattata tggaggttaa tactttacat
     8521 gattcaataa cattattgtt tatgctatta agtgtggttt ggaatatagc ttttctgtat
     8581 tatttatcag ataagttaaa cccttacctg cttgtagttg ggaacacttt tatttgcctt
     8641 ttgattgcac cattgattgc acagacaaag ttctggttta tttttcctta tacctatcat
     8701 tacaaggtgg cacagactat actacattta cgaccgtctg gtgacttaga acaaagtttt
     8761 ggaaatctaa atcattccat agttttattg tgtgtactct tgtcagcaat gttaacgctt
     8821 attatttgta tgttaatgta tcgaaagaag gaatgaatat gaaaataatt caaagtgagt
     8881 ggctgaaaat taaaatgtca tatccaagct atcttatatt aggtttttcg ctaattgaaa
     8941 taatcacgat tttgccatat ttaatatttg tgaaaagtag taaagcttta gaagctgcta
     9001 tcttctttcc aatgctagtt attgcagtaa tcattagctt agtagctatt ttgatttgtg
     9061 aacaagaaga gcaggctaat cactttcaaa tattgattag tgaacgggaa ggagctaagt
     9121 tatgggcggc taagatcata attttagatt taatgctttt actaccaaca attggggtat
     9181 ggagcttatt atacttagtt ttcaagcaag attcatattt aacagttgga ttaatctatt
     9241 ggttattaag tgctttccta aatcattttc acttattgtt agcctttctt ttaggaaata
     9301 gtgggaattt gattgtagcg tttattgagt gtttacttat tatctttgca acaaataagg
     9361 tatttttaga gatgcactgg ttaccaatag cactaccaat taatatgatt ttagaacctg
     9421 tagatgggta tttagtaaac ctatctatct ttatcagttg gatagttttg ctatttttag
     9481 ctcaaatata tttactaaaa tactcaaaaa ttaaaatatt gaagtaatta atcattttat
     9541 tcaaaaaaat atatatagaa aaattttttc tgaacaaatt ctgaaatacg agtattataa
     9601 tacaggtgtt cgaacaaata aaataaattt caaaaattgg aggaaattat aatgcaaaat
     9661 aatgatttta atcttgacct agtgtcaact tcaaaagaaa aaaaacaggg tgcttcacca
     9721 cgtattacta gtatctcatt atgtacagct ggttgtatta caggtagaat tatgggatgt
     9781 cataagacac caacagtttc atgtaactgt cactaattaa ctttttattt gggtagcagc
     9841 tatttagtca tgctaccttt atttttatca gttttgttcg atattgaata aagctgataa
     9901 aagtaaaata aatgctgtag aatgtaattt atttaaaatc tataatcact aatctataat
     9961 cactaaatga agttatgaaa taccaaagga gataggaaaa atggtgaatg acaaatattt
    10021 taagacagat tcttatttaa ttcgaagttc aattttagaa actcagacta aaaattttgt
    10081 gaataatatt gactttttag aacatttgaa gaatgatcaa atgtttttag agcaattatt
    10141 ttttgccaat tcgtctctct actatcaact actaaaatac tatcaaggta acatttctaa
    10201 tactaaaaaa gtagataaaa ttgcaatttc agtatatcga tattataaac gttctcatgg
    10261 aaggccaact ccattgggat tattcagcga aacctctata gggacatttc aagagaataa
    10321 tcatatgaaa cttaatgaaa atgtaaataa aattattaca ttggatgctg aatggttaat
    10381 gttattagtc tataaatttg aatctgagta ctacaactca ctaagtttta ctattaataa
    10441 tgcttgttat aaaaaaggtg ataggattta tcaactttac tcactcattg aagatcaaga
    10501 aaaaattagt attagggaaa cttcagtata taaaataatt tcaaaaaatt gtagtcgggg
    10561 ttactgtaat tatcgaaaac ttattgaaga gttagttagt gtatatggaa tagaaagttc
    10621 taatcttgcc gaggactata ttttaacttt aataaaaaat cattaccttt tatcggatat
    10681 tcaaaaagat atactatgcg gttcaccaag agaaaaattg ttagatttta tttcacgtaa
    10741 ttatatagac attcatataa aaacttcatt gcgtaatatt tttgaaatga ttgatttata
    10801 ctcgaaactt ccaattggag aaggggttgc actcttagaa aaaatttatg aaacaatgtc
    10861 atcaatcgta agaagtaaat cgtaccttaa aattgatctg atatctaact attctgagtt
    10921 ttcattctca actcaaatac aagagaagtt cgaaagattt gcaaacttca tagctctttc
    10981 aacagaatct actaataaaa cacatcttga ttactattca gaagcttttt tagaaaaata
    11041 tggacttgaa agagaagtca aattagttga actattggat ccctgtattg gtttaggagc
    11101 tccatttggt tataatcatc ctagtaatga tttcataatg gaggaaccac cttttgaatt
    11161 ttactccgaa gcggaagaac aaatgtatct ggatctatat actaaagcag ttagtgagcg
    11221 aagacctatt gaactttcat caatagtaaa tcattatgaa aaaattaatt cagaaaagtt
    11281 atctaatata gacggttttg atcttttttt taatatggta aaaaaggatg gtaaaacaat
    11341 ctttagtctt agtaatatta ttggttcaaa tacattaggt ggcggttccg gtcgttttgc
    11401 tggcttgagt ggcactctac agaattttca tgagaaacta ttacaacatg aagatagaat
    11461 tggggactta gataatatta gtacttgcga aattttattt ttaccagaga acttgaggca
    11521 tagaaatatt atgaatactg tttcaaatag aaatttctgc cttcctatat ctacagatgt
    11581 ttctggtaag aaaattttat tagaagatat ttatatagga cttagctcag atttgaaatt
    11641 ttacgctagg gatataagaa gtggagagtt tatcagattt tattctacca atatgtacaa
    11701 tttgacgtta ttttgtaatg agctaagatt tttagttgaa atttcaataa aaaataatat
    11761 tggaaaaata ccttgggaaa taatttataa aaattttagt tatgtaccta gattgacttt
    11821 tgaagatatt atcatagctc ctgcaaagtg gcgtgttcgt gttaatgata ctatgaactc
    11881 agttaatcaa attgtaaaaa aatatggtct acctcaaact ttctatatcg aagaaggaga
    11941 tagtagaatc cttatcaact taactaaaca attggattac aatagttttg aaaatctgtt
    12001 atctagcagc ttccaaaata aaactcagtt aattttaact gaggtcatag gagatgatag
    12061 tccggtagtg agaaacggga aatcaacatc gtctgattta gtgattcctt ttagaaatac
    12121 aaattatttg agtaattgtt cgcacggtta taaaaaaatt gtggaaactc aggattttga
    12181 attgatggat cgagaacgta ggcaattacc atttcaagag tggacgtact ttaaaattta
    12241 tatatcagaa gataggcagg atgagtttct aataggttat ttaacgagac ttaagaatca
    12301 tattttagaa aatgaaggta aggtctttta cttaaggtat agggatccca aacctcatat
    12361 caggcttaga atatcaggat tatcagagaa tatagaattg tattatagtg tactatcaat
    12421 tataaatgaa gcaataaaaa actgtattgt ttctacattt tcaattgata tctatgagag
    12481 agagcttgaa agatatggtg gtagtttact tatgagagaa attgaagata tcttctgtgt
    12541 agattctcaa atttgtattg aaatgattaa ttcctctaaa cttgactccg agctatctat
    12601 tttagattat gcggttttgg ttaattacat atatttaaaa actctcttta taagagatga
    12661 ctcaattatt gaattcctag aggatgtttc cccatcaaat agatcaaaga atttgaataa
    12721 aacaaagcat cactatataa atatgataaa aaattatatt ttgaagaata atctccaatc
    12781 aaattttcct ataataactg aactaagtat attgcttcac tctatccagt tcaaaataaa
    12841 taagttcgaa aaattccgaa aaacatctat tgtggatagt ataatccatg ttcataataa
    12901 tagattaata ggtattgatc gagaacaaga aaaagagata tataatattt taagattggt
    12961 ctttcaaaat gaaaaattta caaaggataa gtaatatgga taaaattacc tccaaacaat
    13021 tattgtctac agtattcacg attccaaata cattaaagtt aatttttcga ctagaaaaga
    13081 aatatgccac atatttaatt gttatcaatg tattaatagc tctatttcca ttaggcatat
    13141 tttacgttta tcaagagtta ataaatgcaa ttttgttgca gtctaataaa gttttacaaa
    13201 cattagtcat atattttata gtgcaaagtg ttagttctat ttttgtacaa attaatgcat
    13261 ttttcctaga gaagttcaat ttaaatttat cttatagctt aagtaaaaaa ttgattacaa
    13321 aaacatcttc actagaattg gctgattttg aaaatgctga cacatataac ctagttgaga
    13381 atctaacaca ggatagtaca tataaaccat atcaattatt caatgctatc ataagtttct
    13441 tttcctctat tatttcttta ctagtttgtt tattttatat aagtacatgg aaaactagta
    13501 ttgcactttt tttgttgtgc atacctctta tttctttagt cactttttta aaaattggac
    13561 aactagaatt tttaatccaa tggaatcgtg ttggtgctga gagaaaagtc tggtattata
    13621 tctacttatt aacacatgac ttttcattta aggaaattaa attaaataac atcagtgact
    13681 atttaattaa taagtttagt ttaataaaag aagaatttat ttctcaagat tcggaaattt
    13741 caaagaaaaa gaatattttt aatgctattt tagacatttt gctgaatttt ataaattgtt
    13801 tagttatcat aatgttaatt tctgctgtta gagcagggga gattttatta ggaaatctaa
    13861 taagtcttat tcaggctctt acaagaatca atacgtactc tcaatctatg atacagagcg
    13921 tatatataat atataatact agcttattca tggagcaatt atttaacttt tttgagtcag
    13981 agcaatatga tcaatcaaat atatatataa ataacacaga tatttcacta aaggaagtat
    14041 cagaaatcaa tttagtggat gttagttatt gttatcccaa tagttctatt aatgcattat
    14101 cagaaatcag cctaagtttt aaatgtggtg aacttgtcgc tattgtgggg aaaaatggtt
    14161 cgggtaaaag tacattagta aaattattat gtgggcttta taagccaagt caaggtgaga
    14221 tagtatttaa tggtatctcg aataaaaatt tagatttagc cttttatcaa aagcatgtat
    14281 cagttctttt tcaagacttt gttaaatatg aattaacttt gagagaaaat atagcattaa
    14341 gtaatttaga aattttaaac gatacacaag ctattaagtt agctttaaag aaattttctt
    14401 ttgaagtgga tcgggatatt gatatgcaat tggggacttg gtttcaagat gggcgccaat
    14461 tgtctggtgg tcaatggcaa aaattagcct tagtaaggac tttcttaaaa aatgcttctg
    14521 tttatatttt agatgaacca agttcagcac tagacccagt atctgaaaaa gaaatattcg
    14581 ataaattcat agagctttct cgtgaccatg tatctatttt tatttcacac aatttaaagt
    14641 cagctaaaaa agcagataag attattgtaa tgaaagatgg aaaagttgat ggagtgggta
    14701 atcatgaaac tttattaagg acaaatgagc actataaaaa aatgtactat tcagaacaat
    14761 atgaggaatt atgatgaaaa tggatgaatt acttgaagat gtctcaaaaa taacaatagc
    14821 tgaatatgat tttgaacttg ataacattat aaatagtaat aataactatg atgttgtgac
    14881 tttatcacgt ggacttccag gttatatatt actagtatcg gaactgaaca gtaatcacgt
    14941 gagttcatat gaagaaaaac tgacttctta tattgaaatt ctagtttcaa tattatcaga
    15001 aagaggtgtt atgacaggct ctctgtattc gggtgctgct ggaattggga ttagcttatt
    15061 acatttaaat gaaaataagt ataaaagatt agtggaaagt ttagatgaat atatcgaata
    15121 tttcgttagt gaatttttac cttcgataga tacgggaaat atgtccccaa cagactatga
    15181 tattatagag ggagtatctg gtatcttagt ttatatctcg cttcatgata gagaaaggtt
    15241 aaaagatgtt caaagaaaaa ttgtaaattt tttgactagt tcattcaaag aggatatatg
    15301 gaacgatatt ttttatgtca cttctcaaaa tcaaatgtct gaatcggaga gcgtactatt
    15361 tcccaaaggt tgcttaaatt taggggtagc acatggctta gcgggagttg gaattgcttt
    15421 agcttacaca atgataaaag gaaactttag ttgtcaaatt gaagaaacct tgcgacatat
    15481 cattgatgta tatgaacaat ttgaaacacc tagtttgtat acatggaagg atggattaga
    15541 tattgatgaa ttaaaacaag gatattctaa ttctaaattc ttaccaaata ttgatgcatg
    15601 gtgctatggt agtccaggca tatctctatt atatatgtat tgcggagttg cattaaatga
    15661 tgagtatctc aagaataaag cagtcgaaat tttaaaaact tcaatggaaa gacaagctgg
    15721 aatagattct cctattttat gtcatggtta tgctggatta ctagaaatat gtcaattttt
    15781 caagtatgta tatcaaacag atgaatttga taaatatatt tatgattttg ataaaaaaat
    15841 tacccaatac ctgcagtcca aaaggaataa cgaattacaa ataatttcac agtttggcta
    15901 tttaaatggc gatgtgggtg ttttattatc tatgttgcac atatattcaa agaatgtgaa
    15961 cacctattgg caggcaggac tacttttatt taaggatata atttttgaat aaacggttcg
    16021 atattctgaa caaaccctga acttttaact ttacaatatc aagtgtaaag gagtacaaat
    16081 tcatgaaaaa agaattttga tcaactgagc gtcaacgttt ttctgtacgc aagtattcaa
    16141 ttggtgttac ttcagtgttg cttgtggtat gtttatttgg ggcaactcag aagagtgtat
    16201 ctgcagatga aatagcagct gcaatcgctt ttcaagaagt tatagtcaat caaaatactg
    16261 cttctgggaa tgaaatagct gaggaattct ctcaaatgga tgatgtacca ttagaaaacg
    16321 aaaaaattaa tgatagtctt gaagacgtca aaactaatat agatgtttct aatgggaaaa
    16381 tagcttattc ctaaaatatt gatgtaaaaa acaagctgaa tcaaatatac tagacgagtt
    16441 agcggtgcat acagaaagtg taacggctac ttcgccagaa tcaagcaaag cagagcctgc
    16501 agatgaagaa ttatctaaac agtcagcaat tacagaggac ttgaatgata caatcccggt
    16561 agaggttgta aaacaagcta ctaatgaagt taaatctagc aaagatggtg gatttttgat
    16621 gacgatttgg ttgcaattga agacttcctt gagcaaaata atgatttgaa attatctaaa
    16681 ggagctactt ctagagcagg gaaagtaata ggtgatgatt atccagctag ttggaaaaag
    16741 agaccagatg agtttgatac ttggggatac aataaatcaa catgtacttc atttgtagcg
    16801 cataggttac atagcgtaaa caaatttgaa gttccaagag caatgggaga tgctggacag
    16861 taggggaata tagcccgtcg attaggctat tgagtagata atactccagc tgttggctca
    16921 gtagcttgga caacaaatgg aacatttggg catgtttctt gggttgcctc agtatcagga
    16981 aatacagtaa cagtagaaga atataactgg aactgggatt atgcttatca cacgcgaata
    17041 caaccgattt cagcatatac tggctttgtt cattttaaag atttaactag cagtaattct
    17101 tctgatgcat caggcggtaa ttcttcagga ggacagacta atctaggaac tatgttactt
    17161 cagcctggaa catatagatt tactagccgt aaaggcatta aatcagaacc taaaatctat
    17221 agtaccgaca tagcttatta tgacagtgga gatacagtca attatgataa aacattagta
    17281 gccgataatc atgagtggat atcatatgtt tcatattctg gggcacgcag atatatcgct
    17341 attaaccagt tagccaaacc agtttcgcct gttgtcaaag gaacaactaa cattcaaaac
    17401 aaaaatgatc agttaggtac ttttgatgtt gtaatttcaa acgtttcagg acgccaatgg
    17461 atttcgtaca ttgcttatag tggtaataga agatatattg cgattagtta actgaattga
    17521 agggaatagc actttgtgag taattcattt tagtgctatc cctctttttt acaataattt
    17581 atgccaatct ggcataaatt ataagattcg ttcaaagctt gactataatg gtgttaggag
    17641 tggacggatg tataggcgtg ttaaggattt aagagaggat aaagattact ctcaagacta
    17701 tcttgcaaag tatttatcct gtagtcaatc agcttattca aggcttgaaa atggtaaaag
    17761 acaattatca atcgaatact taattaaact atcaacttta tatcatgtta gtaccgatta
    17821 tttgcttggt ttaacagatt atccttatcg ccttcatcat aaaaaatagt ctctccttgt
    17881 ttgttcattg acaactgaat agaccaaggt gggactttct tatttgtcga gcagtttagc
    17941 ttgattcgcc atgatatgag cgaacaaaat cagctataaa atagaatggt attctatctg
    18001 ccaagacaca aattaaggat aatgatactt ctgcacgttc gggctgccag cgataaaggc
    18061 cagcgggtgt aactcccatg aatgacctaa ccagtcattc ccgctgaggt cattatttta
    18121 aattttaagg aataatatag tatgacaaaa ataataatag gtgaggacac atcgcaggtt
    18181 gtcattgaag gctacaaagt aacggtaaag gttaccgata agccattgag cctaacggat
    18241 attttagatg atttacttgg tagaaagtta gaaaaaatat aaacttttag cggacaagta
    18301 acagtaaatt atgtaaaata gaatagtaga acttcaatcc ttgattgatc cgcacctaat
    18361 attcgattaa ggagaagaca atgacacaaa cctgtattta tttacgccta tcacgagacg
    18421 atggagataa tattgaaagt aactccattg tcaatcagcg ttcactttta cgagactatg
    18481 cccaaaagca tgaccttatc atcttagaag aatttgtaga tgatggtatt agtggcctaa
    18541 cctttaatcg tccggatttc aaccgtatga tgacgatggt taatgagaaa aggatagata
    18601 ctattatcgt caaagacctg tctcggtttg ggcgagacta tattgagact gggaagtata
    18661 ttcaaaggat tttcccttct attggtgtta ggtttatctc ggtcaatgat cattatgata
    18721 gtttgactgc tgataccaat gaaacacatc ttgtcctgcc gattaaaagc cttatcaatg
    18781 atagctactg tcgggatatt tctatgaaag tccgtagcac acagaaggct aagcgtcaga
    18841 acggagaatt tataggagct tttgcccctt acggttatcg taaagacgat aacgtgagga
    18901 accacctagt agtggatgag agtgctcgtt caatcattga aaaaatcttt acactcaagt
    18961 tagaaggata ttcttccaat aggattgcca cttatctcaa taaagctggc attgcaaccc
    19021 cactccaata taagaaatct tgtcacgaaa atttcaaggg attttatggt aattctaatc
    19081 agtggaatgc caaaatggtt aatcgtattc tggtcaatag agtttataca gggactttag
    19141 aacagggaaa acatacgaaa ctgaattaca aatcgaaaca gtctctaaag gttagtccag
    19201 atgactgggt gcgggtagag aacacacacg aaggtattgt atctgaaagc acctttgaga
    19261 ttgccaatag cttattactt agagatgtca aaaatggaaa agggcagcct tctttattta
    19321 caggattact cttttgtaaa gactgtcaat ctcagatgat acagcgaaaa gtccgttaca
    19381 agaaaataga gaccattcag tacatctgta gtacatacaa caagggaaaa ggttgtagtc
    19441 gtcattctat taaggacgac agcctactgg aagtcatttc aaccttgata gctcaacacc
    19501 tggagtggaa gtcctatctg attgaacgta tccctcatta tctttcacaa gaaccttttc
    19561 ttgaaattga ctttacagga cttgtgaccg aacgaaagaa gtatgagcta ttaatccaat
    19621 ccctgtatat ggacctagat gatggtctta tcaatgagtt ggagtatcag gaatttcaga
    19681 gacattatcg ccaaaagctg aagcaggttg aagaaaccat tgctcttaaa aaagaattag
    19741 ctcaggaact ctatcataaa ctccaagata gggaagcttg gttgaagcaa ttaagtgagt
    19801 tgagagacac agactgctta aaccgcttga cattggtttc cctcttagat cggattaata
    19861 ttggagaaga ccacgagatt acgctggtct ttcatgatat aaaagagatg gatattctcc
    19921 aacagttttc tcaatcggaa acggaggcgg tttgatggct cgcacgaaga atcgctatcg
    19981 tacagaagaa acaaagacta ctcaggttac aatctatcga actggtattt acattagatt
    20041 atctaaggaa agaacagaaa cttggagaaa taaatcacag tcattagaga cacaagaaag
    20101 cttagcgaga acattcgcca aagataaggg cttaatggtt gtcaaggcat atactgatta
    20161 tgagtattca ggcacgaagt ttaaccgccc tgcctttcaa gaaatgatgg aggacattaa
    20221 aaaaggtcat atcaattgta ttctgattcg tgacttatca cgcctgggta gagattatat
    20281 cgaaatgggt cgtcttattg ataaagtttt ccccttcttg ggtgttcgtt tcatctctat
    20341 caatgataac cttgataccc ttaacggact tgaagaaaag aagtcgtttg aggtagaaat
    20401 taagaatttg gttaacgacc tttattctaa agatatttca aagaaagtga ctgcgagtca
    20461 tatttatcat gctagccgtg gctactatat tggaagtttt gctccgtatg ggtatcagtt
    20521 ggacaaacaa gagcatggtg tcaaactgat gatagaccct cttgtaaagc cgattttaag
    20581 aatagctttc gacattttag ttcagggaaa atccattagt aaagtaacgg catatctcaa
    20641 taaagctaga gttgcagttc caaccgtata taggcgaact ggacaactat atcgtagtga
    20701 agatgatcga acagagtgga gaaattcgac tatccttcgt ttaatccaaa gtcctgttta
    20761 tcagggacat cttgtgcagc gtaaatccaa taaaactctt acggagacgg attatattcg
    20821 atttgaatac gctcatgaag cttatatcac tcgagaagaa tatgataaaa tcgttaccta
    20881 tcttcacagc agacggagta ttaaaaaaag gctacagccg aagaggccta atcgatacaa
    20941 gggattgatt tacgctcaag gaaattctaa gcaaatgtat cgctattgtc gtcacttttc
    21001 aaatcagaaa tctgactatg attattatta cttcacggac catgtctatg accctcaaat
    21061 atctgaaaaa cagacagttt atattagtga gatagcttta gatagaataa tctcagagtt
    21121 gcttcaagca gaaatcgaac gtttaggaat agctgagcag ctactgtcta agttgaaaac
    21181 aaaaaaagat gattgtatta aggtttatta taggcaagta aggcaacacc aacaagctat
    21241 cttgcgatta ctagaagaaa taagtgactt atatgcttca tatagtttgg tacggactga
    21301 aaaagcaacc tatctcactc aaaaatctga aaaggaagct caaattgaga cactttcgca
    21361 ggaaataaga cattgtgagg tggctattgg gcaactggaa gaagaacatc agaagcagat
    21421 aagttgggta aaatcgctaa ctcaatgcca aggaacagag actctaacct cggaactatt
    21481 acaggcaatt atcgaacgca tcgaagttga cgtaaataaa caagtaacga ttacttttcg
    21541 ctgtcagctg ggaggtgcag tcaatgtcta aagtagcttt atatcttaga ttatctgtcg
    21601 atgaggctgg aacggatgag agtatttcca ttgtcaatca aagatacttg cttcatcatt
    21661 atctagataa ttcatctgac tttcaaaact ttcagcgaga agaatttgtg gatgacggtt
    21721 tctcagggac aaccgtcaat cgtcctgctt ttcaacgatt gatgacaaag gtaaaatctg
    21781 gcgagattcg tcatgttatt gttaaagacc tctcacgatt tatgcgtgat tatctggagt
    21841 taggaaacta cctggaaaat atattcccct ttctaggagt gaggttcatt gctctaaatg
    21901 accaatatga tagcctgaca tcagagaata atggtgttga gattgacgtt ccctttaaga
    21961 atttgcttaa tgaattttat gctaaggatg tttctgaaaa gatcaagagt gcgatgaaca
    22021 gcatgaaacg ctcgggcaaa aacatgagct ggttgccgcc gtttggttat ctcaaggatc
    22081 cagaggaccg tttcaagatt attattgacg agacagttgc accaattgtt cgacggattt
    22141 tcgccttgta ccttgatggt aatagttacc aaacaattgc tcgactcctg aatgaagaac
    22201 aagtcattac tccagcagaa cgaaagatgc aaatcagtca ggcacgttac gcaaagtcac
    22261 tccgtttaac aactgagcaa aaacgaaatg tttggagtag cactaccgtt ggtcaaattt
    22321 taaagaatga agcccataag ggaacttatc tttttaatac tcggacgtat gtaaggggga
    22381 agcatgtttt cagaccaaaa tcagagtggg agcggattga gaacaatcac gaagcgatta
    22441 tttcatcaga actatttgaa caagttgtcc aattaaaagg atcaaaagcc actaaaagaa
    22501 aacagcatca gatacctaaa acatcatctg tattgacagg tctgattcgt tgtgagcatt
    22561 gtgatcattc tttgattgga cattacaacc atcaaggtta ccaatatttt tcctgtcgtt
    22621 attgtaaggg gcagggagaa aaaatgaagt cttgtcgagt ggataggatt gaacaagcaa
    22681 tcaaagggaa actaggagat gaagcagtaa aacctcatca aaaggtatct aagacccttg
    22741 ttcttcgtga aattgaacgt ttgaagacag aaaaacttgc ctgctttcag gactacaagg
    22801 atagcctgtt gaccagagaa gattatattg ccaagaaaaa ggaagtggat aaatctgttc
    22861 aggctttgga agaacagatg aaagaagcga actgtgttca gttaccaact gacaagaagt
    22921 taagcaaaga aattgtagtt gcacacgttg acaaagttgt ggttgattgt cttggctttt
    22981 ttacagttat ctataaatag ttgaggaaga gacttgaatc ctatcaagtc tctttctcga
    23041 taggttgctt tgtgatataa ttagtgtgaa atctagtaaa taaatagtgt cagtagcttg
    23101 acacaagagg gacatattga agaaggcgag aatttccatg attcggttgt tagagaagtg
    23161 caagaagaaa cgggtttaac agtcactgat gctcgcttgg ttggtcttaa acattggccg
    23221 gataaggaag ggcatcgtta cattgtattt ctctataagg caacagagtt tacaggaact
    23281 atccgatcaa ctgaagaagg cgaggtgcgt tgggtcgaga agtcggacct gcctcagatg
    23341 gatttggcct atgatttgct agaaatactg aaagtcatgg atgagccaga tttgtccgag
    23401 ttcttttata ctagaaaaaa tgacgatgga gagtgggata taaattttag gtagaagcta
    23461 gaaatagctt cttttttatg ctgtttgaat aaaaatacaa caaactagtt gacaaatgta
    23521 taaaaatgac gtaaaatgtt tttatctttc aaaaaaggag aaaaaatatg cattttacta
    23581 taatgaaagt ccgatgtttt atataaaaaa cggtataagt atgcacagga ttgttttaaa
    23641 ggagaatatg atgatgaaaa aatatattat gacgggattg gttttgttgg caacgatgac
    23701 cctaagtgct tgtagtggaa atgctactca agaagatact tccttgaagg atgttcagga
    23761 aaagggaaaa ctaattgttg cattgaatcc agaatttcca ccatttgagt ttagaacact
    23821 ggttgatggc aaagatacaa tcgttggagc tgacattgag cttgcaaaat ccattggtca
    23881 agaattgggt gtagaagtcg aattttcagc gatgagtttt gataatgttt tgaacaatgt
    23941 ccagtcaggg caatcggata ttgccatttc aggaatttca gccactgaag agcgtgcaaa
    24001 agtgtatgat ttttccattc cttactacac ctcaaccaat aaagttatta taaataaaga
    24061 ggatcttgca caatatacat cgcttgattc tctagctgag gcaaatatag gagcacaaaa
    24121 aggttctatt caagaacaaa ttgttaaaga acagcttccg tcttccacgg ttattgctct
    24181 agcttcgaac ggcgagctga ttaatcaatt aaaatcacag aagctagaag cagttatttt
    24241 tgaagagccg attgcgaaag cctatgttgc caaaaatgat gacttggtta ttttagatac
    24301 tgagataaaa agtagctatt cagatgccta tgctattgcc ttgccaaaag gaagtacagc
    24361 tttaaaggaa aaagttgact ctgtcattac aaaactagtg gaatctggac agatggatca
    24421 atttgttcaa gaagcctatg aattatccat tgctaacaat taaattttat acgattaaat
    24481 tgaataaaaa taatattttc ttgacaaatg tataaaaata aattaaaatg agaatacatt
    24541 ctgaaaaact gcaagaaaat acaatgaaaa tcaataagct tgtgtttttt agaataagta
    24601 ttttattaaa ataaagagaa ggtatttagg aaatatgaaa aaaatcttgg cattagcagc
    24661 aacagtttta gcaggactga cattggcagc ttgttcttcg acatcatcac aatctgcatt
    24721 agataaaatt aaagaaaaag gaacattggt agtggcaact agtccagact atgctccatt
    24781 cgagtttcag gcactagttg atggaaagaa tgaagttgtt ggtgcagata ttatgttggc
    24841 tcaaaaaata gccgacgaac ttggggtcaa gcttgaagtt tcagcaatga gttttgacaa
    24901 tgtattgtct agcgttcaaa atggcaaagc tgatattgca attgctggtc tatcttattc
    24961 ggaagagcgt gcaaaagttt ttgatttctc tgaaagttac tatcaaattt ctgatgtatt
    25021 acttatcaaa aaagatagcg ccaattcact cacttcaatt gatgctatga gcgggaaaac
    25081 tctcgcggta caaaagggtt caacacaaga atcctacgca caggaaaaca ttagtcaagc
    25141 taacataatt tctttaacct tgatgggtga agctgtaaat gagctcaaat caggaaaagt
    25201 tgatgctatt ttaatggatt ctccagttgc tgctggttat gtttcacaga attcagattt
    25261 agccgttgca tccgttgaat ttccaacgat tgatgagaat tcgaaagtca ttgctttgcc
    25321 aaaaggtagt acagaactaa aaactgcgat agacaaggtt atcgcagaag taaaagcaag
    25381 tggtgagttt gatactttcc ttgagaaagc tgcaacatat acaagtgttg aataagagaa
    25441 acgagaggct gggcaaaaag tccaaagcca cttctcagag ttcgtgtcaa catctcagcg
    25501 cagtggttga ttggcagatt tgttcgtgtt tcacactcca aatctgacct aatcaactgt
    25561 gcgggggtgg gaagacgaac tcttttttga ctagttgagt tctttcccac tcccttttgc
    25621 atgcaaaaaa gaatggagta agtgagtcac accccaaaag ttagacagaa aattggggtc
    25681 ggttcaatac tccatttttt atagataatt atttcacacg ctctagataa aaactggtca
    25741 aacgtggtac agtaattctg gctccatttt catcgggata gaggctaaat gtgtctattg
    25801 gaatagcatt agatgagaag acaagtttat attcgctctc agctggcaaa tccaagtgta
    25861 cgtcaaatag ttcttgatca ttaaagttat gtatagtcaa gatttcttgc tcatcactag
    25921 tgcgagaaaa agcatacagg cttgcttctt catctatttt tacccaatta aatccttttt
    25981 cataggcttg gtaatcatat ttccagaaag ca
//
