LOCUS       NZ_CP116604            22676 bp    DNA     circular CON 01-MAR-2024
DEFINITION  Streptococcus sp. HN38 chromosome, complete genome.
ACCESSION   NZ_CP116604
VERSION     NZ_CP116604.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus sp. HN38
  ORGANISM  Streptococcus sp. HN38
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2521977)
  AUTHORS   Yang,Q.
  TITLE     Integrative and conjugative elements can act as vectors for
            unconventional circularizable structure carrying optrA in
            streptococcus suis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2521977)
  AUTHORS   Yang,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2023) College of Veterinary Medicine, China
            Agricultural University, No. 2 Yuanmingyuan West Road, Beijing,
            Beijing 100193, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. Unicycler v.0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1.5x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/01/2024 01:35:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,496
            CDSs (total)                      :: 2,423
            Genes (coding)                    :: 2,347
            CDSs (with protein)               :: 2,347
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 27 of 76
            Pseudo Genes (incomplete)         :: 47 of 76
            Pseudo Genes (internal stop)      :: 23 of 76
            Pseudo Genes (multiple problems)  :: 20 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 314911
            Orig. end                         :: 337587
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116604.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22676
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="2"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22676
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22676
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12676](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12676
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    174..188
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.23"
                     /tool="antismash"
     gene            241..1725
                     /gene="thrC"
                     /locus_tag="PHA78_RS01605"
     CDS             241..1725
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /locus_tag="PHA78_RS01605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="threonine synthase"
                     /protein_id="WP_272158372.1"
                     /transl_table=11
                     /translation="MTLVYQSTRDAKNTVSASQAILQGLATDGGLFTPISIPTVDLDFS
                     VLKDASYQEVAKLILSAFLDDFTADELDYCINNAYDSKFDTPVIAPIVKLNGQYNLELF
                     RGSTIAFKDMALSILPYLMTTAAKKHGLENEIVILTATSGDTGKAAMAGFADVPGTQII
                     VFYPRDGVSKVQELQMTTQTGANTHVVAIDGNFDDAQTNVKHMFNDEALRAKLATKKLQ
                     FSSANSMNIGRLVPQIVYYVYAYAQLVKAGEIAAGDKVNFTVPTGNFGNILAAYYAKQI
                     GLPVGKLICASNDNNVLTDFFSTGVYDKNRTFRVTTSPSMDILVSSNLERLIFHLFGND
                     AGKTADLMEALNTAGQYDIQGADADILSLFAAAFATEEETAAEIKRVYDESNYIEDPHT
                     AVASAVYKQYVEQTGDQTPTVIASTASPYKFPVVAVEAVTGQSGLSDFEALAKLYEISG
                     VALPPAVNGLETAPVRHTTVVAAADMQAEVERYLGV"
     misc_feature    1792..1806
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.98"
                     /tool="antismash"
     gene            1853..3613
                     /locus_tag="PHA78_RS01610"
     CDS             1853..3613
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983224.1"
                     /locus_tag="PHA78_RS01610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_272158373.1"
                     /transl_table=11
                     /translation="MAQEQEKISREKKKALLKRLKERIKPKMKLVYLAAFLSWVQFLMR
                     IISFYLIAKGFVSYYEGGQVDLGRFVLILLGLNAFGYGVALIAKRLQGLGSQFARDSLK
                     QSFFEALLAKDGQFDSQATAADVFNIASQGIDSLDTYYSYYMASSLRTQFNCATVLLLV
                     FLIFPLGAVIFILALPLIPISIIAMQKRSKRIMNRYWGSYMDVGNLFLDDLKGLNTLYS
                     YQADATYEKTFNEQAEDFRDATMELLSFQLQAVGYMDAVMYLGIGLSGFVAVNSLAAGN
                     LSLFSMLFFVLIATEFFAPIREQGYGMHLVMMNTKMADRIFGFLDSMTAEREIDSVHVP
                     AFESLKLEDLAFAYGEKPVLEDISMTMTAGKVYALAGESGQGKTTLAQLLLGRLRADKG
                     AIYLGQQEISTVSQLSLNEQVLYVSGQSTLLNQSIYENLRMACDWSKEEVLAWADQHGV
                     LQFVKDLPDGLDTIVGDDGAFLSPGQRQQVICARAVLAKRSLYIFDEVTSSVDQDNEGL
                     IYDLINLVAKDAIVIIITHKMKQVEQADDILFLSAEGAVTGNHATLYQTSSVYRQLVDQ
                     QRELEEAVYG"
     gene            3606..5267
                     /locus_tag="PHA78_RS01615"
     CDS             3606..5267
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646400.1"
                     /locus_tag="PHA78_RS01615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_105256286.1"
                     /transl_table=11
                     /translation="MDKKEMPTSVLIPRLLQSMKHLLPRIAVAVCFAVLGQVVTIAIPV
                     MLVYLAFDALAGNPAPLWTLGALILLALLRGAFRYDEHYFGHYVAFHTLAAYRRLIFAK
                     LRVLAPGKLDRQDSGSLLKMIGEDIEALEVFFAHTIAPICTGILVALGLTVYFGLSSWG
                     LALLALVTYALLAIAIPNRFAKQLQSLLKEQNTSRKGYVSYFTESLKSMKDLMQFQQTD
                     ARFANLTQKSQEVNGQERKVAQTNFMQYAVSFLVVGLSIMGFAWLTFDLVGSQSLDLAT
                     GVALLVSFTSSFAPFLELSRLPLGFKRAMNAGRNIYALLDEKEAERTGELVEVSVADIA
                     IEQLDFDYDDRETGLYRNLSVQFEQGGIIGLVGEFGAGKSTLMKLLMRWYDWQQGQIRL
                     SGLDSRQVDKAHLQGAFAYVPQVPQIFRQTIRENLLLGRTDVSDETIMDLAEKCHMKER
                     ILVAPQGLDTLVEASDFSAGEGQRLELMRALLKNADCYIFDEPTSNLDSLNEARFIQLV
                     KEHCQGMVFLISHRSSTMACADTIFRLEDGQLVKEK"
     gene            5268..5861
                     /locus_tag="PHA78_RS01620"
     CDS             5268..5861
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636793.1"
                     /locus_tag="PHA78_RS01620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MptD family putative ECF transporter S component"
                     /protein_id="WP_014637420.1"
                     /transl_table=11
                     /translation="MKKLQVKDLMVTGAFAALYFVCVGLGTLLSLVFDRSGNMMYAPAG
                     AALLAGPVYMLLVAKVGKFGSISLVGAVMACFFFLSGYMTAAFLPSLTFGFLAEMVAKS
                     GHYKQKWTNLLSYVIFSFGNLGPIILMWFMRDAYEASLLARGKSAEYIARVMLDFTPEN
                     VLWLSTTIILTALISGLFGQYMLQRYFKQSGYLS"
     gene            5858..6517
                     /locus_tag="PHA78_RS01625"
     CDS             5858..6517
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636794.1"
                     /locus_tag="PHA78_RS01625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="energy-coupling factor transporter transmembrane
                     component T"
                     /protein_id="WP_105256285.1"
                     /transl_table=11
                     /translation="MKLDARTKIILVIFTSFTYGMRLTILENAVLVLGLSLLFWFSGKR
                     KMAIMSPIAYSIFCLLSYITFLPVWLTHLLLVLTYTWPPLLAGHLLLMTTSGYELIHGL
                     RKWHLPEVFLLTLGVMFRFLPAIKQDSRTICASLKVRGIFLRKRDVVCKPLQYMEFFLV
                     PLMMSLLRTAQELTVASLTKGLAVSTKSPAYIRSSWTVLDWSLCLCCLGFLILVRL"
     gene            6481..7908
                     /locus_tag="PHA78_RS01630"
     CDS             6481..7908
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002941239.1"
                     /locus_tag="PHA78_RS01630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_105256284.1"
                     /transl_table=11
                     /translation="MLSRFSDSRPAVTVKNVALTYSGADKPALQIEDLTIPEGQCVVLC
                     GESGSGKSSFLKVLNGLTPEYYPAQLSGKIFLGDLDLQKSSLEEISRHIASVFQHPSTQ
                     FFHSQVLQELVFPCENQGLSREEIENRLAWVMELFGLASLSQRTISSLSGGQQQRLALA
                     VAAMQGTDVLVLDEPTANLDQEGIAIVEDILKTLKSQGKTIIIAEHRLSYLSQLADRYL
                     YFQDGQVVTDYLADEFLSRTEECRQDMGLRCYDSEPYGRAIAELADQFVNDKEGLLVEN
                     LSVSQKENTLYEIEKLCLAPGQVVGLVGANGSGKTSLARYMVGLAEDKKSRISWQGQTL
                     SSRQRLEKTAFVMQDVRLQLFAESVERELTLGRKNRTVDEHLVARFGLSDLLERHPVSL
                     SGGEQQRVMIVASLLADKEIFIFDEPTSGLDLRRMQQVASALVDLKMKNKLVLLISHDE
                     ELLNLVCDKIVDIKQLK"
     gene            7914..9191
                     /locus_tag="PHA78_RS01635"
     CDS             7914..9191
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002938993.1"
                     /locus_tag="PHA78_RS01635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_105097069.1"
                     /transl_table=11
                     /translation="MNKQTYKEILTIAFPAMGENLLQMLMGVVDSYLVASIGIVALSGV
                     SLANNILAVYQAVFIALAAAVSSRLAQDLGEGGSEGIGGTASESVKFTVFIGLLLGIFS
                     VLAGPIVLTSLGAESEVVQAGGLYLILVGGGAPFLGLMTSLSAILRTLGEPRFPMYISL
                     LSNVLNALFSAFAVFVLHAGVAGVAIGTVLSRLIGCSLLWSRLPISLKPWTWSFDKELL
                     RLALPATGERLMMRVGDVVVVALITSLGTATVAGNAIGETLTQFNYMPALGIATATIIL
                     TAKHRQDKAMVRHIFRTSFGLSLLFMFLVAGVTYFAGPFLISLYTKDIQAVQASQTVLF
                     YAMLGVPFTAGTLIMTALWQGLGNARLPFYATTIGMWLVRIGIAYLLVTFFKIGLSAIW
                     IATILDNAFRSGVLFFQYRYSKQESI"
     misc_feature    complement(9355..9369)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.89"
                     /tool="antismash"
     misc_feature    9635..9648
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.63"
                     /tool="antismash"
     misc_feature    complement(9680..9693)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.68"
                     /tool="antismash"
     misc_feature    9681..9694
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.68"
                     /tool="antismash"
     misc_feature    complement(9718..9732)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.38"
                     /tool="antismash"
     misc_feature    complement(9878..9894)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.95"
                     /tool="antismash"
     gene            10001..12676
                     /locus_tag="PHA78_RS01640"
     CDS             10001..12676
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="PHA78_RS01640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_272158374.1"
                     /sec_met_domain="Pkinase (E-value: 9.7e-09, bitscore: 32.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.4e-08, bitscore:
                     29.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQENMAIHWYASSNSTNFYIMSNQVVTEESFLKLLSYSIDDVSVY
                     TKKPWIFLKFSQSTSEGRTAGWKIHVSATMENYLEIFNIVCGYCIKNKIDFKFLANEKF
                     LKEINSKEVSRLSAGKFIVVYPKESEFRTVIQDISDLTIMYDGPEVLTDYRYSSSKIIY
                     YRYGEIDPIRRINTYGVVETYILDNEANFVKDEKFPYPFTPDWIKKISLEDASNEESLL
                     LKKYIPMQAIKFSSSGGVYEVTEVNSRKIFVMKEARKFTGQDNTKFYSTDRLKREFSFL
                     KLLERTDFVPQVFEIIEEKGNSYLIEEKLEGINLREYIYLHNPLLTNEKDVKKIDDYFK
                     NCLIIFNNIIAGIGKINDFGIYVQDLSETNIIVNFETNEPTVKLIDLEYAILKKELNGI
                     TNIQTPGFSYIGEIEGIDIYKGYIIGICMIFPIQNMFEFNRANVFKSIQYLKNIINNKY
                     AQKMLNQIEKYIRSFDGATNICKISPDDVSQQLDQIINCILESYCVLEVDHKKIFFPAD
                     PQVYNTNPYSIAHGGLGVLYSLLRISDGKERTILTKIQNISNDIINTTYGALFNDSIDI
                     SSGLMIGELSFVYFLMCENKILEAWNVFNRSFQTLKNSDNTGIYYGISGLVILGAYFGF
                     EGCSETMFSELQELLLERRLETDVVGLYEGESGVALIYLVMYMVTNDRRYLDIGESHVA
                     NILTYVYENSHGNLTVDRVGKNNSGNKIESPFLYNGLSGIGYMLLYYYKVTKNDEYSNV
                     LNSICLSLDYDIHYFATLMRGLAGITDLLITCLQEGVLCDEVSERTSKVVDQQIKTLNL
                     FEQRDESEILFGFLGEGNLKISHDLHSGSSGIALVLYRYVKYKQGIQTASSEFALYLLD
                     EIFRKWRTGYEIKTGMENIA"
     gene            12642..14258
                     /locus_tag="PHA78_RS01645"
     CDS             12642..14258
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="PHA78_RS01645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_272158375.1"
                     /transl_table=11
                     /translation="MKLKQVWRILPKFKICLLLLALVGASFDGIIMSQVISRVSQFSSE
                     STVKDVLLFAGCSILFYLLIQLSDLFVSIIKNDLLKNLHKKYKMELLNYLGNKGNALDV
                     TESLAVLTVDLKLVEDKYFSVLFDCLYYSLLGAVSLIYLVYLSPAISVLFIIFSFLPML
                     PAILFSKYLGTATENFTKSNEKFIRSIKDIFQGFSVLWTYGANRKFLGMAETVVNDLEN
                     SNEALNNKHSIVNLVSSMLSWLSYIVPITVALVFVTQGKLDASIVIALFLASDRVIYPF
                     RNVSNYLRMIQSTEPTRKKLEKMLQDSRQQEVSENHIVESILKPEIHFSGVAIGHGAAI
                     IKNFNATVPYGRKVLIRGASGSGKTTLLDSIQGVLQPLEGEISVLNHQKKISNPSNQMA
                     RIQQSPYYFEASLKENLLMALESVREEELLTLLSELGLVEELGEDCLEKYYGENGAQLS
                     GGQKQRIEIARALLHNKKILLVDEGTSAIDKQSSALIRKKLANLPITIFEVAHHYSESD
                     LGLYDEIWEIHPNSGTIEKIL"
     gene            14274..15149
                     /locus_tag="PHA78_RS01650"
     CDS             14274..15149
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037898.4"
                     /locus_tag="PHA78_RS01650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_029185492.1"
                     /transl_table=11
                     /translation="MKEKIASLIKRTRLEKGFSQKELSEGICAQAVISKIEKAEVSPSV
                     ELFFKLVKKLDIDSSVILELFQLKKSTEESILTDELKSILYRREYDTLEYFLQFFSKDS
                     VSPIQSPYIQYLNGVLLFGKYKKSNEALEILEGLLPTLVENANLFLRVGIAIAGIYSEL
                     EEHVASMNQYESLIHHYHESNDWELKVLFQYGYSRILYLCNNFEKALVYNAESLELLKN
                     RNTLFMLGNTLLMRANILAKRSIISEAIDMVKKSIVVYDLEGDELLKNLAQSFFIDLLE
                     QESKDEKEIN"
     misc_feature    complement(15394..15408)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: strong, score: 25.99"
                     /tool="antismash"
     misc_feature    15693..15702
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            15988..16923
                     /gene="mvk"
                     /locus_tag="PHA78_RS01655"
     CDS             15988..16923
                     /EC_number="2.7.1.36"
                     /GO_function="GO:0004496 - mevalonate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016126 - sterol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /gene="mvk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646405.1"
                     /locus_tag="PHA78_RS01655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mevalonate kinase"
                     /protein_id="WP_002941245.1"
                     /transl_table=11
                     /translation="MSVVGKANGKIILMGEHAVVYGQPAIAMPFSAVEITAQVTAQGQA
                     LSVACDFYEGLVHKMPKIWESLKHAIRFSLYRLGAPTDPAIHIEISSTIPAERGMGSSA
                     AVAVAVARALFAYYEKKLTDSELWDIVQSSEKIAHGNPSGIDAATTSGKSPVFFIKHQP
                     IEPFELKLHAYLVVADTGVTGNTLEAISDVADLLEKKPEAIKLVEELGNLTRQAKEDLA
                     TDQAELLGSRMNQAHALLQKLGVSDPSLDKLVSLAQENGALGAKLTGGGRGGCMIALAR
                     TAQDAQKLVHILDQAGARQTWIQYLGETND"
     gene            16916..17941
                     /gene="mvaD"
                     /locus_tag="PHA78_RS01660"
     CDS             16916..17941
                     /EC_number="4.1.1.33"
                     /GO_function="GO:0004163 - diphosphomevalonate
                     decarboxylase activity [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /gene="mvaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921869.1"
                     /locus_tag="PHA78_RS01660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="WP_002941246.1"
                     /transl_table=11
                     /translation="MTKQTGLARAHTNIALIKYWGKRDKELFLPMNSSLSLTLDAFYTD
                     TKVVFDPELTADEFYLNGILQKEKEILKISRFLDLFCEYIGERAFARVESLNFVPTAAG
                     LASSASAFAALALATATALDLDLSPATLSTLARRGSGSSTRSLFGGFVEWDMGTGSEDS
                     MAHPIDDADWDIGMVVLAVNTGPKKIASREGMDHTVATSPFYTAWVETAKQDLVDIKAA
                     IASRDFVKLGQITEHNGMKMHATTLSANPPFTYWSADSLVAQEAVRQVREESGLSAYMT
                     MDAGPNVKVLCRASQMDELVEGLSAVFPREKIITSKPGPAAYVLSEDDWQASQAAFEKG
                     L"
     gene            17943..19022
                     /locus_tag="PHA78_RS01665"
     CDS             17943..19022
                     /EC_number="2.7.4.2"
                     /GO_function="GO:0004631 - phosphomevalonate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016126 - sterol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646407.1"
                     /locus_tag="PHA78_RS01665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphomevalonate kinase"
                     /protein_id="WP_002941247.1"
                     /transl_table=11
                     /translation="MMVQVKIPGKLFLAGEYAVVEAGYPAVIAAFDQYLTVTIETSDQG
                     SLHSSQKADLYLTWERKGNEVFIQDDHPYALIETAMQVTEAYLTAKGYACHGTYSLAVQ
                     SDLDDQTSGAKYGLGSSGAVTVATVKALLTYYGHRPDALLTYKLAALAQTKLGMTGSFG
                     DLASSSFGGLIAYHSLDRSWLLGKMAELSLLDVVESDWQGLSISPIQLPQGLDLLVGWT
                     GSAASTDRLVSQMEDQKSQAEKEQIHSQFLADSKTCVEQLIVACQTNDSASVRQAITQN
                     RKLLQDFARGMGLVIETPQLSQLCDLAQTYGAVAKSSGAGGGDCGICLVDSTEQKVAIE
                     TAWQQAGILPLTLNIASRE"
     misc_feature    complement(17968..17979)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.98"
                     /tool="antismash"
     gene            19033..20130
                     /gene="fni"
                     /locus_tag="PHA78_RS01670"
     CDS             19033..20130
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fni"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646408.1"
                     /locus_tag="PHA78_RS01670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_044781555.1"
                     /transl_table=11
                     /translation="MFYLGEFGLDRKDQHVGLANQQYSATPAKDFTETLFVHHSLPQTK
                     VDEVDISTSVAGLDFAFPFFINAMTGGSKKTREINRLLGIMGHFGKIALASGSVSAAIK
                     DPSVAETFSVMRRENPYGIIFANLGAHHSVENAKRAVDLLEANAIQIHVNAPQEIVMPE
                     GDRDFTMWLKNIETLVREMEVPVIVKEVGFGMSRETVAQLASVGVQTIDVSGTGGTDFA
                     KIENARRTFNDYTYLEGWGQSTVTSLVEAMSVSEEVRPSLIASGGIKTPLDIVKSLALG
                     ADLVGMSNHFLQYVKDGKGHRFDDGLQAIKTYQWQMAEIMTMLGAKNIADLRKKDLVLA
                     PNVQNWCEARGIDWKAYARRSANVS"
     gene            complement(20225..21973)
                     /locus_tag="PHA78_RS01675"
     CDS             complement(20225..21973)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015646409.1"
                     /locus_tag="PHA78_RS01675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_099806862.1"
                     /transl_table=11
                     /translation="MLSKTKQASVFWRLLSYLKAYRLLTVLALSFLLLTTVVRSLIPLL
                     ASYFIDHYISSISETAVAILAAYFALYLLQMLLQYFGNLWFAKVSYSIVRDIRRDAFGR
                     IEKLGMAYFDQTPSGSIVSRITNDTESISEMFSGILSSFISALFIIITTLSTMFALDWK
                     LTCLIILFLPLIFVLVNQYRKRSAPIVAKTRSLLSSINSKLAESIEGIRIIQAFSQEDR
                     LKEEFEAINQEHLDYASRSMALDSLFLRPALSLVKILAYALLMTYFGLDWAQAGISAGL
                     IYAFIQYVNRLFDPLLDVTQHFSTLQTSMVSAGRVFTLMDQTIEEPLQLDRGAKIDKGH
                     IVFEDVCFSYDGKRQILDKVSFEVRQGQTIAFVGATGSGKSSIINVFMRFYEFQSGRIL
                     IDGQDIRNFSQEELRSAIGLVLQDPFLFHGTIASNIQMYQNISRAEIEDAARFVDAAPF
                     IEKLPEKYDHLVTERGTSFSTGQRQLLAFARTMASQPKILILDEATANIDSETEQTVQT
                     SLEKMRKGRTTIAIAHRLSTIQDADCIYVLDKGKIIESGNHEELLALKGHYHRMYQLQA
                     GQLAAT"
     misc_feature    complement(22590..22604)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 19.98"
                     /tool="antismash"
ORIGIN
        1 gcaagtgttt gttaacaaat catttcttaa taatccttgt ataaacaatt ggactagcct
       61 ccaaaacttt ctcaaacacc agtttacatg tagtaggctg gtgttttgat atttcgtaag
      121 agaaggtaag agccaaaacc ggtctagcgt tcggtttttt gttttatctt gccaattttc
      181 tgtcaattta ggtgggtttt atggtagaat agaaaaaata gattttttat gagggatacc
      241 atgacattag tatatcaatc aacacgcgat gctaaaaata ctgtatcggc tagtcaggcg
      301 attttgcagg gcttggcgac agatggtggt ttgtttacac cgatttccat tccaacagtt
      361 gacttggact tttctgttct caaagacgct tcttatcaag aagttgctaa actgattttg
      421 tcagctttct tggatgattt tacggcagat gaactcgact actgtatcaa caatgcctat
      481 gacagcaagt ttgacacgcc agttattgcc ccgattgtaa agctcaatgg tcagtacaac
      541 ttggagcttt tccgtggctc aaccattgcc tttaaggata tggctctgtc catcctgcct
      601 tacttgatga cgactgcggc gaaaaagcat ggtttggaaa atgagattgt catcttgaca
      661 gcgacttcag gcgatacagg caaggcagct atggctggct ttgcggatgt ccctggcacg
      721 caaatcatcg tcttttaccc acgagacggt gtgtctaagg ttcaggagtt gcagatgacc
      781 acgcagacag gggctaatac gcacgtggtg gctattgacg gtaacttcga cgatgcccag
      841 acaaatgtca aacacatgtt caacgatgag gccctccgtg ccaagttggc gactaagaaa
      901 ctccagtttt catcagccaa ctccatgaac atcggccgct tggtgccaca gattgtgtac
      961 tatgtctatg cctacgctca gctggtcaaa gctggcgaga ttgcggcggg cgacaaggtc
     1021 aacttcaccg ttccaacagg taactttgga aacatcttgg cggcttatta cgccaaacaa
     1081 atcggtctgc cagttggcaa gctcatctgt gcgtccaacg acaacaatgt cttgactgac
     1141 ttcttctcga caggcgttta tgacaagaac cgtaccttcc gcgtgaccac cagtccgtcc
     1201 atggacatct tggtgtcctc taacttggag cgcttgattt tccatctctt tggcaatgac
     1261 gctggcaaaa cagccgatct catggaagct ttgaacacag ctggtcagta cgacattcaa
     1321 ggggctgacg cggatatcct ctctctcttt gctgccgcct ttgcgacgga agaagaaacc
     1381 gctgcggaaa tcaagcgtgt ctatgacgag tcaaactaca ttgaagatcc acatacggct
     1441 gttgcctcag ctgtctataa acagtatgtg gagcaaacag gggaccagac tcctacagtg
     1501 attgcttcta cagcaagtcc ttacaagttc ccagtagttg cggttgaagc agtgacaggc
     1561 cagtcaggtt tgtctgactt tgaagccctg gcaaaattgt atgagatttc aggtgtagcc
     1621 ctgccaccag ctgtgaacgg attggaaact gcacctgtcc gccacactac cgtcgttgca
     1681 gctgcagata tgcaggctga ggtagagcgc tatttgggtg tttaatctat aaatgattac
     1741 taacaaactg ttcagctgaa cagtttgttt tctttttgtt atttaaatta aaatttacag
     1801 ataattcaaa gaatgatata ctatatagga atacttgtag atgaggtggc ctatggcaca
     1861 agagcaggag aaaatctcca gagaaaagaa aaaagccctc ttgaagcggc tcaaagaacg
     1921 catcaaaccc aagatgaagc tggtttattt ggcagccttt ctatcatggg tgcaattttt
     1981 gatgcggatt atttccttct atctgattgc taagggtttt gtgagctact atgagggtgg
     2041 tcaggttgat ctgggacgct tcgtcctcat cttgttgggg ctcaatgcct ttggctatgg
     2101 tgtagccttg attgccaagc gtttgcaggg tttgggctcc cagtttgctc gggattcgct
     2161 caagcagtct ttctttgagg ccctcttggc caaggacggt cagtttgatt cacaggcgac
     2221 agcggcggat gtctttaaca tcgcttcaca ggggattgat agcctggata cctactattc
     2281 ttactacatg gcttcttcct tgcggaccca gttcaactgt gcgaccgttc tcttgctggt
     2341 ctttctgatt ttcccgctgg gtgcggtcat tttcatcttg gccttgcctc tgattcccat
     2401 ttccattata gctatgcaga agcggtccaa gcggattatg aatcgctact ggggctccta
     2461 catggatgtg ggcaatcttt tcctggatga cctcaagggg ctcaacaccc tttattccta
     2521 tcaggcggac gcgacttatg agaagacctt caatgagcag gctgaggact tccgcgatgc
     2581 gaccatggag ttgctcagtt ttcagctgca ggcggtgggc tacatggatg cggtcatgta
     2641 tctggggatt ggactgtctg gttttgtggc ggtcaatagc ctagcggcag gcaatttgtc
     2701 cctctttagt atgctcttct ttgtcctcat tgcgacggag ttttttgcac ccatacggga
     2761 gcagggctac ggtatgcact tggtgatgat gaataccaag atggcggatc gtatctttgg
     2821 tttcttggac agtatgacag cggagcggga aatcgattct gtccatgtgc ctgcttttga
     2881 aagtctaaaa ctagaagatc tggcctttgc ctacggagaa aagccggtcc tagaagatat
     2941 ttccatgacc atgacggctg gtaaggtcta tgccttggcg ggcgagtcag ggcaggggaa
     3001 aacgaccttg gcccagctgc tcttgggacg cttgcgggcg gataagggag ctatttactt
     3061 ggggcagcag gagatttcga ctgtcagtca gttgtctctg aatgagcagg tcctctatgt
     3121 gtcgggccag tcaaccttgc ttaaccagtc aatctatgaa aatttacgca tggcttgtga
     3181 ctggtccaag gaggaggtct tggcttgggc agatcagcat ggggtcttgc agtttgtcaa
     3241 ggatttgcca gacgggttgg acacgattgt gggtgatgat ggtgctttct tgtcgcctgg
     3301 tcaacgccag caggttatct gtgcccgtgc ggtcttggcc aaacgctccc tttatatctt
     3361 tgacgaggtg acgtccagtg tcgatcagga caatgaaggc ttgatttacg atctgattaa
     3421 cttggtggcc aaggatgcga ttgttattat tattacccat aagatgaaac aggttgagca
     3481 ggcagatgac atcctcttcc tgtctgctga aggagctgtg acaggcaatc atgctacgct
     3541 ttatcagact agctcggtct atcgtcagct ggtcgatcaa caaagagaat tggaggaagc
     3601 cgtttatgga taagaaagaa atgccaacaa gtgtgctgat tccgagactc ttgcagtcca
     3661 tgaagcacct cttgccacgg attgcggtgg cggtttgctt tgcggtcttg ggacaggtgg
     3721 tgaccattgc tattccagtt atgctggtct atctggcttt tgatgcactt gctggcaatc
     3781 ctgctccgct atggaccttg ggagccctca ttctcctagc tcttttacgt ggtgccttcc
     3841 gctatgatga gcattacttt ggtcactatg tggcctttca tacgctggcg gcctatcgtc
     3901 gtttgatttt tgcaaaactg cgggtcttgg ctcctgggaa attggaccgg caggacagcg
     3961 gtagcctgct taagatgatt ggggaggaca ttgaggcctt ggaagttttc tttgcccata
     4021 ccattgctcc tatttgtaca gggattctag tggctcttgg tttgacggtc tattttggtt
     4081 tatctagctg gggtttggct ttgctggctc tggtgaccta tgcccttttg gcaattgcta
     4141 ttccaaatcg gtttgccaag cagctgcagt ccttgctcaa ggagcaaaat accagtcgta
     4201 agggctatgt gtcctacttt actgaaagtc tcaagagcat gaaggatctc atgcagttcc
     4261 agcagacaga tgctcgcttt gccaatctga cgcagaaaag ccaagaggtc aatggtcagg
     4321 agcgaaaggt cgctcaaact aactttatgc agtatgccgt ttctttccta gtggttggtt
     4381 tgtctatcat gggctttgcc tggctgacct tcgacttggt gggcagtcag agtttggact
     4441 tggcaactgg agtagccctg ctagtttctt tcactagctc ctttgctccc ttcttggagc
     4501 tcagccgtct gccgcttggt ttcaagcggg ctatgaatgc tggtcgcaat atctatgctc
     4561 ttttggatga aaaagaagca gagcgaacag gtgagctggt tgaggtcagc gtggcggaca
     4621 ttgctatcga acaactggac ttcgactacg atgaccgaga aacagggctc tatcggaacc
     4681 tgtctgttca gtttgaacag ggtggtatta ttggtttagt cggtgagttc ggtgcaggta
     4741 aatccacttt aatgaaattg ctcatgcggt ggtatgattg gcagcaaggt caaatccgcc
     4801 tgtctggctt ggatagtcgg caggtagata aggcacattt gcagggggcc tttgcctatg
     4861 taccacaggt gccgcaaatc ttccgccaga ccattcggga aaatctcctc ttgggtcgga
     4921 cagatgtgtc ggatgaaacc atcatggact tggcagaaaa atgccacatg aaagaacgga
     4981 ttttggtagc accgcagggc ttggatacgc tagtagaggc tagtgacttt tcagcaggag
     5041 agggacaacg cttggaactc atgcgggcct tgctcaaaaa cgcagactgc tatatctttg
     5101 atgagccaac tagtaaccta gattcgctca atgaagcccg ctttatccaa ctggttaagg
     5161 aacattgtca gggcatggtc ttcttgattt ctcatagaag ctcgaccatg gcctgtgcgg
     5221 ataccatttt ccgcttggaa gacgggcaat tagtaaagga aaagtaaatg aagaaattac
     5281 aagtaaaaga tctgatggta acaggggctt ttgctgccct ctactttgtt tgtgtgggtc
     5341 taggaacctt gttgagcttg gtttttgatc gttcgggtaa catgatgtat gcacctgctg
     5401 gagcagccct tttggcagga cctgtttata tgttattggt agccaaggtt ggtaaatttg
     5461 gttcaattag tctggttggt gcggtcatgg cctgtttctt tttcctgtca ggctatatga
     5521 cagcggcctt tctcccaagt ttgacctttg gttttttggc agaaatggta gcgaagtcag
     5581 gtcactataa acaaaaatgg accaatcttc ttagctatgt cattttctct tttggaaact
     5641 taggacctat tattcttatg tggttcatgc gagatgccta tgaagctagt ctattggcac
     5701 gtggaaaatc agcagaatac atcgctcgtg tcatgcttga tttcactcca gagaatgtgc
     5761 tatggttgtc aacgaccatt atcttaacag ctcttatcag tggtttgttt ggtcaatata
     5821 tgcttcagcg ctattttaaa caatcaggtt atctttcatg aaattagatg ctcgtacaaa
     5881 aattattctc gtcatcttca ctagttttac ctatgggatg aggcttacaa tattagaaaa
     5941 tgcagtgctg gtcttaggcc ttagcctgct tttctggttt tctggaaagc ggaaaatggc
     6001 tataatgagt ccgatagcct attctatttt ttgtctgttg tcctatatta catttttacc
     6061 agtatggctg acgcatttgt tgcttgtatt gacctataca tggcctccgc ttttggcagg
     6121 gcatctatta ctgatgacga caagtggtta cgaactcatt catggcttgc ggaaatggca
     6181 cctaccagag gtatttcttt tgacgttggg agtaatgttt cgtttcctac ctgccattaa
     6241 acaggattct cgtacgattt gtgcctcttt gaaggttaga ggaatttttt tacggaagag
     6301 agatgtggtt tgtaagccac tccagtacat ggagtttttc ttggttccct tgatgatgtc
     6361 tctcttgcga acagctcagg aattgacagt agccagtctg acaaaaggtt tggctgtatc
     6421 tacgaaatca cctgcctata ttcggtcgtc ttggaccgtg ctagattgga gtctttgttt
     6481 atgttgtctc ggttttctga ttctcgtccg gctgtgacgg tgaaaaatgt agcattaact
     6541 tattcagggg cagataaacc agccttgcag atagaggatc tgaccattcc agaaggccag
     6601 tgtgttgttt tatgtgggga gagtggctct gggaagtcta gttttctcaa ggtgttaaat
     6661 ggtttgacgc cagaatatta tcctgctcag ctttcgggaa aaattttctt aggggacttg
     6721 gatttacaaa aatctagtct ggaagaaata tctcggcaca ttgcttcagt ctttcagcat
     6781 ccgtctactc aattttttca tagtcaggtc ttgcaggaat tggttttccc ttgtgaaaat
     6841 cagggtttgt caagagaaga aatcgagaat cgcctggctt gggttatgga attatttggt
     6901 ttggcttctc ttagccagcg aacgatttcc agtctatcag gtggtcagca acaacgtcta
     6961 gccttggccg ttgcagccat gcaagggaca gatgtcttgg ttttagatga gccgactgcc
     7021 aacctagatc aggaagggat tgcgattgta gaggacatct tgaaaacttt aaaaagccaa
     7081 ggcaagacca ttattattgc cgagcataga ctgtcttatc tcagtcaatt ggcagatcgc
     7141 tatttatatt ttcaagatgg gcaagtggtg acggattatc tagcagatga gtttttaagt
     7201 cggacagaag aatgtcgtca ggatatggga ctgcgttgtt atgactcgga gccttatggg
     7261 cgggcaatag cagagctggc agaccagttt gttaatgata aagagggttt acttgttgaa
     7321 aatttatcgg taagtcagaa agagaatact ctctacgaga ttgaaaaact ctgcttggca
     7381 ccaggacagg tggtgggttt ggttggagcg aatggttctg gaaaaacaag ccttgctcgt
     7441 tatatggtcg gtttagcgga agataagaag agtaggattt cttggcaagg tcaaacctta
     7501 tctagtcgcc agagattgga aaaaacagcc tttgttatgc aggatgttcg actccaacta
     7561 tttgcggaaa gtgttgagcg agaacttact cttggaagga aaaatagaac tgtcgatgaa
     7621 catttggtag ctcgttttgg cctatcggat ttgttggaga gacatccggt cagtttatcg
     7681 ggtggtgaac aacagcgtgt gatgatagta gctagcttac tggcagataa ggaaattttc
     7741 atttttgatg aaccgacgag tggcttggat ttgagacgaa tgcagcaagt tgcttccgct
     7801 ttagtagact taaaaatgaa gaataagttg gttttgttaa tttctcacga tgaagagcta
     7861 ttgaatctgg tttgtgataa aatagtagat attaaacagt tgaaatagag attatgaaca
     7921 aacaaaccta taaagaaatt ttaaccattg cctttccagc catgggggaa aaccttctcc
     7981 agatgttaat gggggtagta gactcttatc tagtagccag tattggtatc gtagctttgt
     8041 ctggagtttc ccttgctaat aatattttag ccgtctatca ggcggttttt attgccctag
     8101 cagcagcggt gtcttctcgt ttggctcagg atttgggtga agggggttca gaaggcattg
     8161 gaggaactgc tagtgaaagt gtcaagttta cagtttttat cggtctcctt ttaggaattt
     8221 tttcagttct ggcaggtcca atagtactta ctagcttggg ggcagagtca gaagtggtac
     8281 aggctggagg tctttatttg atattggttg gtgggggagc accttttttg ggactcatga
     8341 caagtttgag tgcaatctta cgaaccttgg gggaaccacg ttttcctatg tatatcagcc
     8401 tgctctcaaa tgttctaaat gcactatttt cagcatttgc agtctttgtg cttcatgcag
     8461 gtgtagctgg agttgcgatt ggcacggtat tatcgcggtt gattggttgt agcctgcttt
     8521 ggtctcgctt accaatttct ttaaaaccat ggacctggtc ctttgataaa gaactgctta
     8581 gacttgccct gccagcaact ggtgaacggt tgatgatgcg ggtgggagat gtggtagtcg
     8641 tggctttgat taccagttta ggaacagcga cggtagctgg aaatgcgatt ggagaaaccc
     8701 tgacgcagtt taactatatg ccggctttag ggattgctac cgctacaatt atccttacag
     8761 cgaaacacag acaggataag gctatggttc gacatatttt tcgaacaagc tttggtcttt
     8821 ctttgctgtt tatgtttttg gtggctggtg tgacttattt tgcggggcct ttcctaatca
     8881 gtctttatac taaggatatt caagcggtac aagctagtca aacagtatta ttttatgcca
     8941 tgttgggagt tccctttaca gctggcactc ttattatgac agctctttgg caaggtttgg
     9001 gaaatgctag attacccttt tatgccacaa ctatcggtat gtggctagta cggattggca
     9061 tagcttattt acttgtaaca ttttttaaaa tcggtttgtc agccatttgg attgcaacga
     9121 ttttagataa tgctttccga tcaggggtgc tattttttca gtataggtat tcaaaacaag
     9181 aatcaattta agataaggct aagaaaattt tcagtttcgt ttaagcttgt agctatatac
     9241 tatattcaag ctagaaatag cgaatttctt tttcatataa tctccagaga acagtcgacc
     9301 gcggtcggct gttttcgtgt ttgggtgcaa ttagtaattt catagtcaag aaaatatttt
     9361 cagaaaaact ttttgatttt cagtttcgtt taagtttgta gctatatact atattcaagc
     9421 tagaaatagc gaatttcttt ttcatataat ctccagagaa cagtcggccg cggccggctg
     9481 ttttcgtgtt tcggtgtgct ttgaaagtaa tattcgttca tcttttcacc taaaggtgtc
     9541 cctatctacg ttaacagtct ttttcaacta aaatcttttt aaggcttttt tatatctagt
     9601 taaatctgta aagtgaattt ttctcgttag atagattttt agtaaaaaac actaaacaac
     9661 aaaatatagt tcaaaaatat tataaaaatt ataaaatata caaaaaaagt gtttgacttt
     9721 ttaaaatgag tatattatac tgtatttagt tgatcagcta aaaaattaga agggagaaaa
     9781 ctatgtctga tttgcgtcaa ttacaaacat tatctgttaa gagtagtttc gtagacagta
     9841 caggagctac ggcacagggg tcttgtgtat ttgctagttg taatacaact actagagaac
     9901 agtagttaag gtgcgtcttt ttcataattt gttaatgttg aacactgcat agtataaaaa
     9961 ttatgcagtg ttcaatgtta ttttatatgg tggtgtaaaa atgcaagaaa atatggcgat
    10021 tcattggtat gcttcatcga atagtacaaa tttttatatt atgagtaatc aagttgttac
    10081 ggaagaatct tttttaaagc tactctcata cagtatagat gatgtaagtg tatatacgaa
    10141 aaaaccttgg atttttttga agttttctca atctacttct gaaggacgaa cggcaggatg
    10201 gaaaatccat gtgtcagcaa ctatggagaa ttatcttgaa atatttaata tagtgtgtgg
    10261 atactgcatt aaaaataaaa ttgatttcaa attccttgca aacgaaaaat ttttgaaaga
    10321 aattaatagt aaagaagtat ctagactttc agcgggaaaa tttattgtag tttatccaaa
    10381 agaatctgaa ttcaggacag taattcaaga tatttcagat ttaacaatta tgtatgatgg
    10441 accggaagta ttgactgatt ataggtattc ttcatcgaaa ataatttatt atagatatgg
    10501 ggagattgac cctataagaa gaataaatac ttatggtgtg gttgagacat acattttaga
    10561 taatgaagct aattttgtaa aagacgaaaa gtttccttat ccatttacac cggattggat
    10621 aaaaaaaata tctttagaag atgcgagtaa tgaagaatct ttgttactaa agaaatatat
    10681 tcctatgcaa gcaataaagt tttcttcatc aggaggtgta tacgaagtta ctgaggtgaa
    10741 ttcacgaaaa atttttgtaa tgaaagaggc tcgaaagttc actggacaag ataataccaa
    10801 attttattct actgataggt taaaaagaga attctcattt ttgaaattat tggagaggac
    10861 agattttgtt ccacaagtat ttgaaataat tgaagaaaaa gggaatagtt acctaattga
    10921 agaaaaacta gaagggataa atttaagaga atatatttat ctgcataatc cattattgac
    10981 aaatgaaaaa gatgtcaaaa aaattgatga ttattttaaa aactgtttaa taatattcaa
    11041 taatataatt gcaggaatag gcaaaattaa tgattttggt atttatgtac aggatttgtc
    11101 cgagacgaat attattgtga actttgaaac aaatgagccg actgttaaat taattgattt
    11161 agaatatgca attttgaaaa aagaattaaa tggtataacc aatattcaaa cccccggatt
    11221 ctcctatatt ggagaaattg aaggtataga tatttataaa ggttacatta ttggaatatg
    11281 tatgatattt ccaatacaaa acatgtttga atttaaccgt gccaatgttt tcaaaagtat
    11341 ccagtattta aaaaatataa ttaataataa gtatgctcag aaaatgctga atcaaataga
    11401 aaagtatatt agatcatttg atggtgcaac aaatatatgt aaaatttctc ccgatgatgt
    11461 cagtcagcag ttagatcaga taataaattg tatacttgaa agttattgtg ttttagaagt
    11521 agaccataaa aaaatttttt tcccagcaga tccgcaagtt tataatacaa atccctatag
    11581 cattgctcat ggggggctag gtgttttgta ttcgttacta cgaatttctg atggaaaaga
    11641 aagaactata ttaaccaaaa ttcaaaatat tagtaacgat attattaata ctacatatgg
    11701 ggcgttattt aatgattcta ttgatatttc gagtggatta atgattggag aattgagttt
    11761 tgtatatttt ctcatgtgtg agaacaaaat attagaagca tggaatgttt ttaatagaag
    11821 tttccaaaca ttaaaaaata gtgataatac ggggatatat tatggtattt ctggattggt
    11881 tattttaggg gcatactttg gatttgaagg atgttctgaa acaatgtttt cagagttaca
    11941 agaattgttg ctggaaagac ggctagaaac agatgtagta ggattatatg agggggaatc
    12001 tggtgttgcg ttaatatatt tggtaatgta tatggttaca aacgatagac gttatttaga
    12061 tattggagag agtcatgtag caaatatctt gacgtatgta tatgaaaact cacatggaaa
    12121 cctcactgta gatcgagttg gaaaaaataa ttctggaaat aagattgagt ctccattctt
    12181 atacaatggt ttgtcaggaa tcgggtatat gttgctttac tattataaag taactaaaaa
    12241 tgacgaatac tcaaacgtgt taaacagtat ttgtttgagt ttagattatg atatccatta
    12301 ttttgctact ctgatgcgtg gattggcagg gataactgat ttattaatta cttgtttaca
    12361 agagggagta ttgtgtgatg aagtctcaga aagaacatca aaagtagttg atcagcaaat
    12421 caaaactttg aatctttttg aacagagaga tgagagtgag atattatttg gatttttagg
    12481 tgaaggaaat ttaaaaattt cccatgattt acattcaggt agtagtggaa tagcgctcgt
    12541 cttatataga tacgtcaaat ataagcaagg catacaaaca gcatcctcag aatttgcttt
    12601 atatttactt gatgaaatct ttagaaaatg gagaacgggt tatgaaatta aaacaggtat
    12661 ggagaatatt gcctaagttt aaaatatgct tactcttgct tgcattggta ggagcgagct
    12721 ttgacgggat tattatgtct caggttattt cgagagttag tcaatttagt tcggaatcaa
    12781 ctgtaaaaga tgttttacta ttcgccggtt gcagtatatt gttctattta ttgattcaat
    12841 tatcagattt atttgtttca ataataaaaa acgacttact aaaaaatctg cataaaaagt
    12901 ataagatgga actgttaaac tatcttggaa ataaggggaa tgcattagat gttacagagt
    12961 ctcttgcagt attaacagtg gatttaaagt tagtagaaga taaatatttt tccgttcttt
    13021 ttgattgctt atactacagt cttttagggg cagtttcatt gatatatctt gtctatctaa
    13081 gtcctgcaat ttctgtatta tttattattt tctcatttct tccaatgttg ccagcaatac
    13141 tatttagcaa atatctagga actgcaacag agaacttcac taagtcgaat gagaaattta
    13201 ttcgtagcat aaaagatatt tttcaaggtt tttcggttct atggacatat ggtgcgaatc
    13261 gtaagttttt agggatggct gagacagttg tcaatgactt agaaaatagt aatgaggcat
    13321 taaataataa acacagcata gttaatcttg tttcttccat gctgtcgtgg ttaagttata
    13381 ttgttccaat aactgtagct ctagtatttg taacccaagg gaaactagat gctagtattg
    13441 ttatcgcttt atttttagcc agtgaccgtg ttatctatcc atttagaaat gtttcgaact
    13501 atttacgaat gatacaatca acggagccaa ctcgaaaaaa attagagaaa atgttacagg
    13561 attctcggca acaggaagtg tctgaaaatc atattgttga atcaatattg aagcctgaga
    13621 ttcatttttc aggagtagcc attggacatg gagcagcaat tatcaaaaat tttaatgcta
    13681 cagtcccata tggtcgtaaa gtactgatta gaggagcttc aggaagtgga aagacgacct
    13741 tactagatag catacagggt gtactgcaac cgttggaagg ggaaatatct gtattaaatc
    13801 atcagaaaaa aataagtaat cctagcaatc aaatggcaag aatccaacaa tcgccctact
    13861 attttgaggc aagcttaaaa gagaatctcc taatggcgct tgagtcagtg cgtgaggagg
    13921 agttgttaac cttgctttca gagctggggt tggtagaaga gctgggtgaa gattgtttag
    13981 agaaatatta tggtgaaaat ggggcgcagt tatcaggagg acaaaaacaa cgtattgaga
    14041 ttgccagagc cctccttcat aataagaaaa tcttgttagt tgatgagggg acatcggcaa
    14101 ttgataaaca atcctcagcc ctcattcgta aaaaacttgc caatttacca attacaatct
    14161 ttgaggttgc tcatcactat tcagagtcgg atcttggtct atacgatgag atatgggaaa
    14221 ttcatccgaa tagtggtaca atagagaaaa tattatgaat tggaatgtga attgtgaaag
    14281 aaaagattgc tagtcttatt aagcggacgc gtttggagaa aggatttagt caaaaagaac
    14341 tgtctgaggg tatttgtgct caagcagtta ttagtaaaat tgaaaaagct gaagtttctc
    14401 catcagtcga attatttttt aagctcgtca aaaaattaga cattgattct agtgtgatat
    14461 tggaattgtt tcaactaaag aagagtacag aagaatctat tcttacggat gaattgaaat
    14521 ccattcttta ccgaagagag tatgatacat tggaatattt tttgcagttt ttttcaaaag
    14581 attctgtatc tccgattcaa agtccatata tacaatacct taacggggta ttgttatttg
    14641 ggaaatacaa aaagtcaaat gaagctttag agattttgga agggttgctg cctactttgg
    14701 ttgaaaatgc taatctattt ttacgagttg ggattgccat tgcgggaata tattcggagt
    14761 tagaagagca tgtagcatca atgaaccaat atgaaagtct cattcatcac tatcatgagt
    14821 caaatgattg ggagttgaaa gtattatttc aatacggata ttctagaatt ttgtacctgt
    14881 gtaacaactt tgaaaaagcc ttggtttata atgcagaatc actagaatta ttaaagaatc
    14941 gaaacacttt atttatgtta ggcaatactt tgttaatgag agccaacata ttagcaaaac
    15001 gctccattat ttcagaagca attgatatgg tcaaaaaatc aatagttgtt tatgacttag
    15061 aaggcgacga gctcttaaaa aatttagctc agtcattctt tatagattta ttggaacagg
    15121 agtcgaaaga tgaaaaagaa attaattaaa tttagtgtat tattgcttac atatgtgatt
    15181 ttatttggag ataagattcc accagtaata ctaagttgac attaggaatc ggtttagatg
    15241 atgataaaac acctaaattc ctcagaataa gtcggaatta ggtgcttttg attggtgtaa
    15301 aaagatgaga agtattaata tagtggtttg aattaggaaa aggacggttt taagttatag
    15361 tgttaataac ccactcctaa aatgacttta gagttctcaa attgacaaac ttagatatgt
    15421 cctgtttcta attcactcta ctatagttcc gagtttctag gctgtattca aatttttaga
    15481 tacgataata tataaaatcg tatgaatttt acagttcagt ggactgtaag aggtctgagc
    15541 cttgaaactc aaagcaaaga ggaaatatac agcctcattt tgcggccggc tgttttcgtg
    15601 tttcggcgca ttttggaagt ttgtttatac tcatttaaaa tcaaaaatag ccacctacca
    15661 ctcaaagtgg atatggagcg ttttgatttt gttatttttt gagaagaaaa cagctacttg
    15721 aaatccacaa ttctcaactc aaacttataa attaaggttt cgcatgttat aagtagctta
    15781 gacttgctat ttttgatttt tattgagtat tagtttatat tcgctcatct tttcacctaa
    15841 aggtatccct atctctaagt cgcaagcgac aaagagctag gtatcatata atctccagag
    15901 aacagtcgac tgcggtcggc tgttttcgtg tgttctattc ttatgtaaaa atggtataat
    15961 agtagtgatt gtaataagga gaaaagtatg tcagtagtag gaaaagcaaa tggaaaaatc
    16021 attttgatgg gagagcatgc ggtggtctat gggcagccag caattgctat gcctttttct
    16081 gctgtggaaa ttactgctca ggtgactgcc caaggccagg ctctcagtgt agcctgtgat
    16141 ttttacgaag gcttggtgca caagatgcca aaaatctggg aaagcctcaa gcatgccatc
    16201 cgtttctcgc tctatcgtct cggagcgccg acagatcctg ctatccacat cgaaatcagc
    16261 tccactattc ctgccgagcg cggcatgggc tccagtgcag ccgtggcagt agcagtagca
    16321 cgcgccctct ttgcctatta tgaaaaaaag ctgaccgaca gcgaactctg ggacatcgtc
    16381 cagtcttcgg aaaaaattgc ccacggcaat ccctcaggca ttgatgcggc aaccaccagc
    16441 ggcaagtccc ccgtcttttt tatcaagcac cagcccatcg aaccttttga gctgaaactc
    16501 catgcctatt tggtggtggc tgatacaggt gtgacgggaa acaccttaga agccatttca
    16561 gacgtggcgg atttgttgga gaaaaagcca gaggctatca agctagtaga agaactgggg
    16621 aacttgaccc gacaggccaa ggaagattta gccacagacc aagcagagct tctaggtagc
    16681 agaatgaacc aagctcatgc tcttctgcaa aaattaggcg tgtctgatcc tagcctggat
    16741 aagctagtca gccttgccca agaaaatgga gccctcggag ccaaattaac tggtggcggc
    16801 cgaggaggtt gcatgattgc cctggcaaga acagctcagg atgcccaaaa acttgtacac
    16861 atccttgacc aagcaggcgc ccgccaaacc tggatacagt acttaggaga aaccaatgac
    16921 taaacaaaca ggccttgccc gtgcccatac caatattgcc ttgattaaat actggggaaa
    16981 acgcgataag gaattatttc tacctatgaa ttccagttta tccctaaccc ttgacgcatt
    17041 ttatacggat accaaggttg tttttgaccc agaattaact gccgatgagt tctatctcaa
    17101 cggaatttta caaaaagaaa aagaaatttt aaaaatttct cgatttttgg atttgttttg
    17161 cgaatatata ggtgaaaggg catttgcccg agtggaaagt ctaaattttg ttccgactgc
    17221 ggctggtttg gcaagctcag catcagcctt cgcagccctt gcacttgcaa ccgcaactgc
    17281 cttggattta gatttgtccc cagccaccct atcaaccctt gctcgcaggg gttctggctc
    17341 tagcacccgt agcctattcg gtggatttgt tgagtgggat atgggaactg gttcggaaga
    17401 ttctatggct caccccattg acgatgcgga ttgggatatc ggcatggtcg tcttggcggt
    17461 caataccgga ccgaaaaaga ttgctagtcg agagggaatg gaccacacgg ttgccacctc
    17521 accattttac acagcctggg tagaaaccgc taagcaagac ttggtggaca tcaaggcagc
    17581 tattgccagc cgtgattttg taaaacttgg tcagattaca gagcacaatg gcatgaaaat
    17641 gcatgcaaca acgctctctg ccaatccacc atttacctat tggtcagccg atagcctagt
    17701 ggcccaagag gccgtccgtc aggttcgtga ggaaagtggc ttatcagcct acatgaccat
    17761 ggatgctgga ccaaatgtca aggtcctctg ccgagcaagt cagatggatg aattggttga
    17821 gggactatca gcagtctttc caagagagaa aatcatcacc agcaagcctg gacctgctgc
    17881 gtatgttctc agcgaagacg attggcaggc atcacaagca gcatttgaaa agggcttgta
    17941 gcatgatggt acaagtaaag atacctggaa aactctttct agcaggggaa tacgcagttg
    18001 tcgaggctgg ttatcctgcg gtgattgcgg cgtttgatca gtacctaacc gtcaccattg
    18061 aaacaagtga ccaaggcagt cttcattcca gccaaaaggc ggacctttat ctgacctggg
    18121 agcgtaaggg aaatgaggtt ttcatccaag atgaccatcc ctatgctctg attgagacag
    18181 ccatgcaggt gacagaagcc tatctgacag ccaagggcta tgcttgtcat ggaacttaca
    18241 gtctagcggt ccagtctgac ctggatgacc agacttcagg tgccaagtat ggtctggggt
    18301 cgtcaggggc agtaacggtt gcgacggtca aggccttgtt gacctactac ggtcaccgac
    18361 cagatgccct cctgacctac aagctggcag ccttggccca gaccaagcta ggcatgacag
    18421 gctcctttgg ggatttggcg tcctccagtt tcggtggctt gatcgcctat cattccctgg
    18481 accgttcttg gcttttaggg aaaatggcag agctgtccct gctggacgtg gtggaaagtg
    18541 attggcaagg tttgtctatc agccctatcc agttacccca aggcttagac ctcttggtgg
    18601 gatggacagg atcggcggct tcgacggaca ggctagtttc ccagatggaa gaccaaaaaa
    18661 gtcaggcaga aaaagagcaa attcatagcc agtttctagc cgactccaag acctgtgtag
    18721 agcagttgat agtagcttgt cagacaaatg actcagcgtc agtaagacag gctattactc
    18781 aaaaccgcaa gctcttacaa gattttgcga gaggaatggg cttggtcatt gaaacccctc
    18841 aactgagtca actctgtgac ctggctcaga cttatggagc ggtggccaaa tcatctggtg
    18901 caggtggtgg tgactgcggc atttgcctgg ttgacagtac ggaacaaaaa gtagcgatag
    18961 agacggcttg gcaacaagcc ggcattcttc cactcaccct aaacatcgca agtagagaat
    19021 aaggagaacc ctatgtttta tctaggagaa tttggtttag accgcaagga tcaacacgtt
    19081 ggcttggcca accagcaata tagtgccaca ccggccaagg attttacgga gaccttgttt
    19141 gtccatcatt ccctgccgca gaccaaggtg gatgaagtgg atatttcgac cagtgtagct
    19201 ggtttggact ttgcttttcc cttcttcatc aatgccatga ccggtggaag taagaagacg
    19261 cgggaaatca atcgtctgtt gggaattatg gggcattttg gaaagattgc tctggcttct
    19321 ggttcggtta gtgcggcgat taaggatccg tctgttgcgg aaaccttctc cgtgatgcgt
    19381 cgggaaaatc cttacgggat tatctttgcc aacctaggtg cccatcatag tgtggagaat
    19441 gccaagcgag cggtggattt gttggaggcc aatgccattc agatccatgt caatgccccc
    19501 caggagattg tcatgcctga gggagaccgt gactttacta tgtggttgaa aaatattgaa
    19561 acccttgtac gtgagatgga agtacctgtc atcgtcaagg aagttggttt tggcatgagc
    19621 cgtgaaacag tagcccagct ggcttctgtc ggtgtgcaaa ctattgatgt atctggtact
    19681 ggggggacgg atttcgccaa gattgaaaat gcccgccgta ccttcaatga ttatacttat
    19741 ctagaaggtt ggggtcagtc aactgtgact tccttggtag aggctatgtc tgtttctgaa
    19801 gaagttcgcc caagcctgat tgcatctggt ggtattaaga cgccactaga tattgtcaaa
    19861 tcattggccc tcggtgcaga ccttgtcggt atgtccaacc atttcctcca gtatgtcaag
    19921 gatggtaagg ggcatcgttt tgacgacggc ttgcaggcta ttaagactta tcaatggcag
    19981 atggctgaaa tcatgaccat gttgggggct aagaatattg cagaccttcg caagaaagat
    20041 ttggttttgg ctccaaatgt acaaaactgg tgcgaagcgc gtgggatcga ctggaaagcc
    20101 tatgcccgtc ggtcagcgaa tgtgagttaa agagagatag actgatgtct tcagttctca
    20161 acaatgtaga aaaataaaaa agccaggtcc attttggaac ttggcttttg taatggagtg
    20221 gtgcctaggt cgctgctaac tggcctgctt gcaactggta catgcggtgg tagtgaccct
    20281 tgagggctag aagttcttcg tgattgcctg actcgatgat tttccccttg tccaagacat
    20341 agatacagtc ggcatcttga atggttgata aacggtgagc gatggcgatg gttgtccgcc
    20401 cctttcgcat tttttcaaga gaggtttgca ccgtttgctc cgtttccgaa tcgatattgg
    20461 cggtagcctc gtctaaaatg agaatcttag gctgactggc catggtgcgt gcaaaggcca
    20521 gaagttgccg ttgaccagtc gaaaaagagg taccccgctc agtgaccagg tggtcgtatt
    20581 tctcaggaag tttctcaata aagggggcag catccacaaa tcgagccgca tcttcaatct
    20641 ccgctcggga aatattctga tacatctgga tattggacgc aatggtccca tgaaatagaa
    20701 agggatcttg caggactagg ccgatcgcgg accgcaattc ttcctgcgaa aagttacgaa
    20761 tatcctgacc gtcaatcaga atccgcccag attggaactc atagaaacgc ataaagacat
    20821 tgatgataga agacttgcct gaccctgtag cacccacaaa ggcgatggtc tggccctgtc
    20881 tcacttcaaa ggaaacctta tccagaattt gccgcttacc gtcataggaa aagcaaacat
    20941 cctcaaagac aatatgcccc ttgtcaatct tggctcctcg gtccagctgt agaggttcct
    21001 cgatggtctg gtccatgagc gtaaagactc gtccggcaga taccatagag gtttggaggg
    21061 tggaaaaatg ttgcgtgaca tccagcaagg gatcgaaaag acgattgacg tactggatga
    21121 aagcatagat cagaccagca gaaatcccag cctgtgccca gtccaaaccg aaataggtca
    21181 tgagcagagc gtaggccaaa atcttaacaa gtgaaagagc agggcggaga aagaggctgt
    21241 ccaaggccat ggagcgacta gcataatcca gatgttcctg attgatagcc tcgaactctt
    21301 ctttcaatcg atcttcctga gaaaaagcct ggataatccg aattccttca atactttcag
    21361 ccagtttgct gttgatagaa ctcagcagac ttctagtctt ggccacaata ggagctgacc
    21421 gttttctgta ttgattaacc aagacgaaaa tcaagggaag aaagaggatg atcagacagg
    21481 tcaatttcca atccagagca aacattgtcg aaagagtcgt gatgataata aagagagcgg
    21541 agataaaact ggataaaatc cctgaaaaca tctctgaaat actctctgta tcattggtga
    21601 tgcgagagac aatggagcca ctaggagtct gatcaaagta agccattccc aacttttcta
    21661 ttctcccaaa agcatccctg cgaatatccc tcacaatgct ataggaaact tttgcaaacc
    21721 agagatttcc aaaatactgg agcagcattt gaagcagata gagggcgaag taggccgcta
    21781 gaatagcaac cgcagtctca gaaatagaag aaatgtagtg gtcgataaaa taggaagcca
    21841 gaaggggaat caaactgcga acaacagtcg tcagcagcaa aaagctgagg gcaaggactg
    21901 tcagcagtcg ataggctttg agataggaca agagtcgcca aaaaacacta gcttgtttgg
    21961 tcttagagag catcgctttc ctccttttct aattgctgca tcatataggt atcgtaatac
    22021 cagccttttt catctagtaa ttcttggtga cgacctcgct ctacgatttt cccatcttca
    22081 agaaccagaa tcaagtctgc atggacaatg gctgataggc gatgggcagt gataatggtg
    22141 gtcttatcaa ggcgttcttg cttgatggtt tcgagaatag cgtgttctgt tttagcatcc
    22201 accgctgaga gcgaatcatc caagagtaga atatctggat tgagaatcat ggcacgggcc
    22261 atagccaacc gttgtttttg tccgccagaa agggaaatcc ccttttcgcc gaccatggta
    22321 tcaaagcgat cgggcatatc ccgaatatcc tcatagacat gaacagcccg agcggcctct
    22381 tctacctggt ctagtgagag gtctggatta ccaaagcgga tattttcagc aatgctggtc
    22441 gcaaagagga attggtcttg gggtacatag ccgattaatc gtcgcaggtc agctagcttg
    22501 tagttcttga tatcttcttg attgagcaaa atctgtccat ttgtcacatc gtattctcgc
    22561 atcaggagct tgagcaggct ggtcttccca gagcctgttg gccccacaag gccaatcgtc
    22621 tggccttttt cgatgtgaaa ctggatgttt tggaggactg gtatgttatc ataggc
//
