LOCUS       NZ_CP116604            17731 bp    DNA     circular CON 01-MAR-2024
DEFINITION  Streptococcus sp. HN38 chromosome, complete genome.
ACCESSION   NZ_CP116604
VERSION     NZ_CP116604.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus sp. HN38
  ORGANISM  Streptococcus sp. HN38
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2521977)
  AUTHORS   Yang,Q.
  TITLE     Integrative and conjugative elements can act as vectors for
            unconventional circularizable structure carrying optrA in
            streptococcus suis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2521977)
  AUTHORS   Yang,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2023) College of Veterinary Medicine, China
            Agricultural University, No. 2 Yuanmingyuan West Road, Beijing,
            Beijing 100193, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. Unicycler v.0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1.5x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/01/2024 01:35:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,496
            CDSs (total)                      :: 2,423
            Genes (coding)                    :: 2,347
            CDSs (with protein)               :: 2,347
            Genes (RNA)                       :: 73
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 27 of 76
            Pseudo Genes (incomplete)         :: 47 of 76
            Pseudo Genes (internal stop)      :: 23 of 76
            Pseudo Genes (multiple problems)  :: 20 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:57:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 241690
            Orig. end                         :: 259421
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116604.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..17731
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..17731
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17731
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:12731]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12731
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            461..2794
                     /locus_tag="PHA78_RS01220"
     CDS             461..2794
                     /GO_function="GO:0030983 - mismatched DNA binding [Evidence
                     IEA]"
                     /GO_process="GO:0006259 - DNA metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009659728.1"
                     /locus_tag="PHA78_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endonuclease MutS2"
                     /protein_id="WP_099809128.1"
                     /transl_table=11
                     /translation="MNSKIIETLEFHKVRQKIEPYLLTEQGFEELRQLEPMVEVHRIQQ
                     AFDELTDIAQIFVENPYFSMAATSDIGPAMRRLELDTDLNISELLAVKRVLEVSKTLLD
                     FYGNLENVSLSQLDKLFEKIELFPHLQGSLQSINDAGFVEDFASEKLARIRRKIREAED
                     QVRQVMQDILKTKGDMLSDSILASRNGRNVLPVKNTYRNKIAGVVHDISASGSTVYIEP
                     RAVVTLNEEISHLRAEERHELNRILQELSDMLRPHSGVIRNNAWLIGHIDFVRAKHLFA
                     RDHQAVVPKLSEKQDIALLNVRHPLIAEPVPNDLYFGSQLTAIVITGPNTGGKTIMLKT
                     LGLTHLMAQSGLPILADKGSRVAIFKEIFADIGDEQSIEQSLSTFSSHMTHTVEILRAA
                     DQDSLILFDELGAGTDPQEGASLAMAILDDLRLRGIKTMATTHYPELKAYGIETSGIEN
                     ASMEFDSNSLRPTYKFMQGVPGRSNAFEIARRLGLSDIIIQSAQSWTDTDSDVNRIIEK
                     LESQTVESRQRLDKIRDVEQENYKMNRALRKLYDELNRERENELNKARLEAKEIVDMAL
                     AESEDILKNLHAAASLKPHQIIEAKAELKKLVPEVVDLSKNKVLKKAKIQREAKVGDDI
                     IVTAYGQRGTLTNQLKDGRWEAQVGLIKMTLTKDEFELVKAEKAEQPKKRQVHTVKRAN
                     VRGPKARLDLRGKRYEEAMMELDEFIDQALLNNLAQVDIVHGIGTGVIREGVTKYLRRN
                     KQVKEFGYAPQNAGGSGCTIVTFK"
     gene            2916..>4247
                     /locus_tag="PHA78_RS01225"
                     /pseudo=""
     CDS             2916..>4247
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611311.1"
                     /locus_tag="PHA78_RS01225"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLHKEKPDYNRNQYGFYTLDQLVPADHFLRQVEAVIDFDFIYDLV
                     EDTYSSDNGRPSLDPVMLVKIPLIQCFYGIRSMRQTIKDIEVNTAYRWFLGLTLDDKVP
                     HFTTYGKNYSRRFQEKGLIESIFTHILGLCINAGLIDPTEIFIDGTHIKAAANNRKFIN
                     QEVEKQAKFMSEQLEIEINQDRVKHGKKPLGPAKEPEPIAKKISTTDPESGWFHKGDHK
                     EVFAYSAQVACDKYGWALAYSVEAGNIHDSQAFPALFAKLEPLKPEYIIADSGYKTPSI
                     AKFLIDKEITPVLPYTRPRGKKGQLRPKDFVYDEHFDCVLCPEHQALTYRTTTREGYRE
                     YKSDPAICANCPLLSVCTTSKNHQKVVTRHIWKEYLEQCEDIRHQRGMKELYQHRKETI
                     ERLFGTAKEYHNLRYTREKGKSKMEDKIGLTLACLNLKKLAKRMA"
     gene            complement(4377..4775)
                     /locus_tag="PHA78_RS01230"
     CDS             complement(4377..4775)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_029180393.1"
                     /transl_table=11
                     /translation="MIEIFPYSITSYLTSFIIHLFLIARKQWFAVKTKLGYEPYNSWKP
                     TTYFIVKSRALSSEKMHFFLRDIRQRSELANIIIIGKDIDYEELFRNHYRVFGVIDTSE
                     DQSFGYIRKEIFHYLDALYPSQTPGKKR"
     gene            5001..5228
                     /locus_tag="PHA78_RS01235"
     CDS             5001..5228
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003062179.1"
                     /locus_tag="PHA78_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_024376261.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.7e-08,
                     bitscore: 30.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKIMERFEELRSDKLLTIEGGFPWGTLFSGAIDAMDGGGQTLD
                     QLNGKWPKRNPPRPCTPFGTGGTPNACNGL"
     gene            5209..5514
                     /locus_tag="PHA78_RS01240"
     CDS             5209..5514
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_044672279.1"
                     /transl_table=11
                     /translation="MLVTDYNIQDNPESEIEIWQVSKSGPQPIWVQEAFAKHYFQWLDN
                     RLRILVAGLNKEWWHQSGRYYGQGMYVLAEIGDIVDKTHCRIFTEKQFQKQYGQKA"
     gene            5805..6146
                     /locus_tag="PHA78_RS01245"
     CDS             5805..6146
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016296.4"
                     /locus_tag="PHA78_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_024378069.1"
                     /transl_table=11
                     /translation="MPFLMIRTAKEWIKLPLDQVYDITSHPDKAHYVRIKTAGKSYDVL
                     DSLSRLEKEYSPVLVRCHRNCLVNLSKIREIDVEKRALILESNRPIAFSRRRYQELRQL
                     WLNKGEEIR"
     gene            6146..6886
                     /locus_tag="PHA78_RS01250"
     CDS             6146..6886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012516119.1"
                     /locus_tag="PHA78_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_024376264.1"
                     /transl_table=11
                     /translation="MNVFVLEDDFAQQSRIESIVGSLMERHHIQTKKFEVFGKPDQLIR
                     AVEEKGAHQLFFLDIEIRADDKKGLEVAQQIRDIDPFAIIVFVTTHSEYMPLAFRYQVS
                     ALDFIDKELAPAEFEARIETALLYANGKNSRTVAEDSFYYKSRYAQVQVPFADILYIET
                     SPHPHRVILHTEKDRLEFTGNLADILKQEKRLLQCHRSYLVNPNNVVKVDRQMKVLYFR
                     NGSNCYVARNRMELVHNAIRDLHR"
     gene            6896..8227
                     /locus_tag="PHA78_RS01255"
     CDS             6896..8227
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="PHA78_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_099780237.1"
                     /transl_table=11
                     /translation="MSFLFFVIAIVVMFVLPYLSIAWISGRKLPWTYLALGFLVDLGLN
                     ILTIVYPDLAVITFSSEIITKLLVSYLLFGKESKTLAVFYAFFTSILFNLFHRSLVFFL
                     LPMFGWDKEVLWEPLGRSVSGIVCWALVFFFLKWLGYDFSQLWSRTLDEKDRKVLTVTN
                     YLMIGYFFLNHILIYLEQIYQIDTVVYRQFIVVVYLVLFMGVVYQLDRHIKERLQAALL
                     LQKERQLQDMERYSQHIEGLYREVRGFRHDYANLLTTLRLGIDNQDLSLIEEVYQSVFK
                     GSNASFRHQKYDVGRLIHLDNPALKSLLAVKFMQAAEQGIAVSLEVPNPISPKGIELLD
                     FITIASILCDNAIEATMETEQPSMSIAYLSLGDKQLFIVENTTKEESVALANLTDFGRS
                     SKGEGRGIGLYTVREILNGYLNVSLNTSSCNHTFCQVLEIMVEK"
     gene            complement(8425..8574)
                     /locus_tag="PHA78_RS01260"
     CDS             complement(8425..8574)
                     /GO_function="GO:0005186 - pheromone activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015035.4"
                     /locus_tag="PHA78_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ComC/BlpC family leader-containing
                     pheromone/bacteriocin"
                     /protein_id="WP_079267743.1"
                     /transl_table=11
                     /translation="MDKQKHNTSFTQLSDTELQSIIGGDWWTDFIKLIPKPFDIALPGK
                     RKQG"
     gene            complement(8672..10033)
                     /locus_tag="PHA78_RS01265"
     CDS             complement(8672..10033)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012766651.1"
                     /locus_tag="PHA78_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="WP_024378067.1"
                     /transl_table=11
                     /translation="MNTNLFRSAEFYQRRYHNFATLLILPLVLLVSFLFLFSFLAKKEV
                     TVTSRGEITPTKVIASIQSTSNNPILANHLVANQAVKKGDALIQYAETMEASQKQALES
                     QVHNLEEQKKGLETLRNSLEQGTNLFTGEDNFGYGATFQQFVSQTQDLELGIAKTNAEV
                     TNQAALANHTAAAIDQQLSQLQQDIIAYEELKTAISTQASSLPTGNPHQATLNNYLAQL
                     QGTPNPALSDQYISQINQTIAGLENSMASLSIQRAGTGSIATYDTSLATKIESLRAQFL
                     QNAAQQLTTVESQLLQAKSQLDQAATQLEQTTITAPENGVIALNPEFEGKNLIPVGSDI
                     AYLYPDIKQTKTVLITYYVTSEYVALLKEGQTARLSLEKIGNQPIIVIGSIQSIAQSAT
                     PTEEGNLFKITAQATITENESSLLQYGLQGRVTSVIAKKTFFDYYKDKLLHTNN"
     gene            complement(10043..12196)
                     /locus_tag="PHA78_RS01270"
     CDS             complement(10043..12196)
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0043214 - ABC-type bacteriocin transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000205155.1"
                     /locus_tag="PHA78_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="WP_024376267.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.5e-43, bitscore:
                     145.0, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1129.4,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKIKKTFVPQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTN
                     KEGTTALGIVKAAHEMGFETRAIQADMSLFDMTDIPYPFIVHVNKEGKLQHYYVVYKNL
                     KDQVLIGDPDPTVKVTKMSKERFASEWTGVAIFLAPEPSYKPHKDKKNGLLDFLPLIFQ
                     QRTLIFYIVLASLLVTLINIAGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMM
                     TFSRDYLLTVLSQRLSIDVILSYIRHIFKLPMSFFATRRTGEVISRFTDANSIIDALAS
                     TILSLFLDVTILTIVGGVLLVQNTHLFLLSLISIPIYVVIIFAFIKPFERMNNAVMQSN
                     SMVSSAIIEDINGIETIKSLTSEEQRYQKIDSEFVDYLEKSFTLSKYSILQSTLKQGAQ
                     LILNITILWLGSQLVMTGKISIGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRL
                     NEVYLVESEFQEGQTLTDPSFLKGVIQFEDVSYKYGFGRDTLSDIQLTIKEGDKVSLVG
                     ISGSGKTTLAKMIVNFFEPYKGRITLNHNDLKMVDKKVLRQYINYLPQQAYIFSGSILD
                     NLTLGANQTISQEDILKACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQKQRIALARAL
                     LTKAPVLILDEATSGLDVLTEKKVIDNLMAMTDKTIIFVAHRLSISERTNQVIVLDQGK
                     IIETGSHQELMSRGGFYHHLFSK"
     misc_feature    12413..12427
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.22"
                     /tool="antismash"
     gene            12501..12731
                     /locus_tag="PHA78_RS01275"
     CDS             12501..12731
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018364969.1"
                     /locus_tag="PHA78_RS01275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin class II family protein"
                     /protein_id="WP_024376268.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.8e-14,
                     bitscore: 51.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKTMEQFEVMDVEMLASVEGGYSAGKCLADIGWGMVEGVVTGA
                     IAGGLMGAGIGFGLGQIGGSIYCIGNVLGGK"
     gene            12733..12924
                     /locus_tag="PHA78_RS01280"
     CDS             12733..12924
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS01280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_024376269.1"
                     /transl_table=11
                     /translation="MNLLENLPDQTLELTTGGGSVNWVVAGTQCLGAGVIGLIGGPWTA
                     LGACVISGGRSITGDLLN"
     gene            13427..13567
                     /locus_tag="PHA78_RS01285"
     CDS             13427..13567
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS01285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153308671.1"
                     /transl_table=11
                     /translation="MQLSESKLSEVQGGSRDSYCSGQIAARVIFKRLLGQVILPTDLIC
                     Q"
     gene            13587..13727
                     /locus_tag="PHA78_RS01290"
     CDS             13587..13727
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS01290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153308672.1"
                     /transl_table=11
                     /translation="MKQIQFRELSEIDLEATNGGDWLKDVGDYWSGVIDGIKDAFGIRR
                     K"
     gene            13742..14353
                     /locus_tag="PHA78_RS01295"
     CDS             13742..14353
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="PHA78_RS01295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_024378066.1"
                     /sec_met_domain="Abi (E-value: 3.1e-16, bitscore: 56.8,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVESDKSVRQYIPLLLILLVYPYGIGLVAREFVADALVFVTGLVT
                     LFLLYRQGYGDILVFRKPTWKIVRRVILAFLCKLCWAVIVYHFLSSTKNEEALDSWSYT
                     GVQLFLYNLYLLVYGPICEELVFRGYMMRSLAPVSHLQLDVLCSACLFSLGHVLPTGWV
                     LNDFLVYLGSGLIYAILFKKSATIYPVIILHIMWNSLMVL"
     gene            14515..14811
                     /locus_tag="PHA78_RS01300"
     CDS             14515..14811
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020523.4"
                     /locus_tag="PHA78_RS01300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_024376271.1"
                     /transl_table=11
                     /translation="METREKIMEELINLILNPTTTAEERKLLVAYKQEFERTRDTERTI
                     LALAESIRKLAVRNVFYRISLSPGLSQFYKKISAYGEWEKNLGRGLIATGIIR"
     misc_feature    14873..14886
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.61"
                     /tool="antismash"
     gene            14955..16010
                     /locus_tag="PHA78_RS01305"
     CDS             14955..16010
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024498.4"
                     /locus_tag="PHA78_RS01305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioredoxin fold domain-containing protein"
                     /protein_id="WP_024378065.1"
                     /transl_table=11
                     /translation="MKKNLLASSLVCTIVLTSLQGSVIQAETTGQADSSPVVTEVVQPT
                     EEKEGTAPTSETEETAETTGSSSTVNEEVSQAVEISLEDYLETVAAFQKIDIGAVRAAF
                     TEDNQEHLLYFGRGTCYYCRQFSPELKNLHQLTGGKIEYYDTAGEDFDDTAKEFLFKEV
                     GIPGTPTILYIKNGQVLAGWVGGGISAQELYDYFYLGKTPPQLVAGEEQAPSATDEQAP
                     VETALPTTQEVPQGEQASQDRQEAPKEQGSPQEVETAPKDTQPSQESQEASKNEADASL
                     LELTEPNPSRVSAVRQVKPVLPTSPAQSAGTKILPKTGEASSEIGWPMGLLTLMLALVI
                     QGLAIIHKEAE"
     gene            16010..16711
                     /locus_tag="PHA78_RS01310"
     CDS             16010..16711
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942016.1"
                     /locus_tag="PHA78_RS01310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_272158359.1"
                     /sec_met_domain="Abi (E-value: 9.6e-16, bitscore: 55.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLKKIALFVGLILLTIVFNLLPMLFIGQEAQTPVAMKWVFSIA
                     YLALVGFLIFLIGKRYRQQVTETVRELRFTWKDFGIALLFFLATRVVAVLGTLLVQIGT
                     GNTMSANDAALFATSEQVATMFPLYFIAFHVAIGLFAPVMEEIVFRGFFSQYFFKTGNK
                     WLKLVISSSIFALFHIVYPIEFVTYFALGAIFYLAYARRGSIKDAIAVHILNNSLLVLF
                     SVINYLIILFG"
     gene            16728..16874
                     /locus_tag="PHA78_RS01315"
     CDS             16728..16874
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PHA78_RS01315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153308673.1"
                     /transl_table=11
                     /translation="MKELSKAQLVSIIGGGQLSSLIGLPIVVKGPGREIPKPRPVQPPA
                     EIM"
     gene            16973..17617
                     /locus_tag="PHA78_RS01320"
     CDS             16973..17617
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008087192.1"
                     /locus_tag="PHA78_RS01320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_024376274.1"
                     /transl_table=11
                     /translation="MNIREYQTSDEKGWVYCKALSYLFSPFFDDRETEKPALLTDIYDK
                     RIELVAESDDQIVGLIDIDIYSQETSQTYLYAPSQRTAYLTNLAVHPDYQGQGIAQALY
                     EKAEQALKEAGVEKLAIFTRDGDAANHLYKKWGGQLICTDYLVIGTPKDTPYVRFGVDL
                     PNAKLAFTDEAGQPEPYYLREGVYVVTDQADLELFDIEEVYQELTYVVDLV"
ORIGIN
        1 catttatact cttcgaaaat caaaatcaga cgttgttgat ttgatgagtg ggagtgggaa
       61 agaactcgag cagtctaaaa gagttcgtct tcccaccccc gcacagttga ttaggtcaga
      121 tttggagtgt gaaacacgaa caaatctgcc aatcaaccac tgcgctgaga tgttgacacg
      181 aactctgaga agcgaggatg gactttctgc ccagcctcag cctgttccct tgaaatataa
      241 aaggaacaga gttcgatctg catcagagcg aaacgaacta cgttcgccta tttccaacct
      301 ccaaaggttc ggggaacctt tggagcaagt ctgatttgga ttttcattga gtattagttg
      361 actgttatac ctttaattaa gagattggga aagactatat ttttatcttt tattgttttg
      421 ataatgagat aaagctaagg aaaagattaa gtaggaacat atgaatagta aaattattga
      481 aacccttgaa tttcacaagg taagacaaaa aattgagccc tatctcttga cggaacaggg
      541 ctttgaagaa ttgcgacagt tggagcctat ggtggaagtc caccgtatcc aacaggcctt
      601 tgacgagttg acagatatag cgcagatttt tgtggaaaat ccctatttca gcatggctgc
      661 tacgagtgac attggtccag ccatgcgtcg tttggaattg gatacagacc tcaatatctc
      721 agaattattg gcagtcaagc gagtcttgga agtgtccaaa actctcttgg atttttatgg
      781 aaatctggaa aatgtcagtc ttagtcagct ggataaactc tttgagaaga ttgagctttt
      841 tccacattta cagggctccc tccagtccat caatgatgct ggttttgtag aggattttgc
      901 ctcagaaaag ctagcccgta ttcgaagaaa aatccgtgaa gctgaagacc aagttcgtca
      961 ggtcatgcag gatattttga agaccaaagg cgacatgctg tccgatagca ttttggcaag
     1021 ccgtaatgga cgcaatgtcc ttcctgttaa aaatacctat cgcaataaga ttgctggggt
     1081 tgtccatgac atttcagctt cgggttcgac cgtttatatt gagccgcggg cagtggtgac
     1141 cttgaacgaa gaaatcagtc acctacgtgc agaagaacgc catgagctca accgtatctt
     1201 gcaggaattg tcggatatgc tccgtccgca tagtggcgtg attcgtaaca atgcctggct
     1261 tatcgggcat attgatttcg tccgcgctaa gcatctcttt gcgcgtgatc atcaagcagt
     1321 tgtacccaaa ctatctgaga agcaggatat tgcccttctc aacgttcggc atccgctgat
     1381 tgctgagccc gttccaaacg acctttattt tggcagtcag ttgacagcga ttgtcattac
     1441 aggtcccaac acgggtggta agactatcat gctcaagacc ttgggtttga cccatctgat
     1501 ggctcagtct ggtttgccta tcttggctga taagggcagt cgggtagcta tcttcaaaga
     1561 aatttttgcg gatattggtg atgaacagtc gattgagcag agtttatcaa ccttctccag
     1621 tcacatgacc cacacggtgg aaattttaag agcagctgat caagattctc tcattctctt
     1681 tgacgagttg ggagcgggga cagatccgca ggagggggca tccttggcaa tggctatttt
     1741 ggatgacctt cgtctgcggg gcatcaagac catggcgact acccactacc ctgagctcaa
     1801 ggcctacggg atagaaacct ctggtattga aaatgccagc atggagtttg atagcaatag
     1861 cctgcgtccg acctataagt ttatgcaggg tgttcctggt cgctccaatg cctttgaaat
     1921 tgcccgccgt cttggtctgt cggacatcat tatccagtcg gctcagtctt ggaccgatac
     1981 agatagcgac gtcaatcgaa ttatcgagaa gttagagagc cagacggttg aaagtcgtca
     2041 gcgtctggat aagattcgtg atgtggagca agaaaattac aagatgaacc gagccctccg
     2101 caagctctat gacgagctca atcgtgagcg ggaaaatgag ctcaacaagg cacgcttgga
     2161 agccaaggaa attgtagata tggcattggc agaaagcgag gatattctga aaaatctcca
     2221 tgctgcagct agtcttaagc cccaccagat tatcgaagcc aaggcagagc tgaaaaagtt
     2281 ggtgcctgaa gtggtggatc tgtctaaaaa caaggtgctg aagaaagcta aaattcagag
     2341 ggaagccaag gtgggcgatg acattatcgt tacagcttat gggcaacgtg ggaccttgac
     2401 caatcagctc aaggacgggc gttgggaagc ccaggttggc ttgattaaga tgaccttgac
     2461 caaggatgag tttgaactgg tcaaggcgga aaaggcagag cagcctaaga agcgccaggt
     2521 tcacacggtc aaacgtgcca atgtacgagg accaaaagct cgcttagatc tccgtggcaa
     2581 acgctacgaa gaggctatga tggagctgga tgagtttatc gaccaagctc tgctcaacaa
     2641 cctagcccaa gtcgatattg ttcacggtat cggtacaggg gttatccgag aaggggtgac
     2701 caagtacctc cgtcgcaaca agcaggtcaa ggaatttggc tatgctccac aaaatgcagg
     2761 tggttcaggt tgtaccattg tgacctttaa gtaaaaacac aaagcacctg caggtgcttt
     2821 cagactgaag acaaagtcct tagaattgat tttctaaggg cttttcttcg tatttaggag
     2881 tataatataa gaaaaaggac ttatgaggtt ctcctatgct acacaaagaa aaacctgact
     2941 ataaccgcaa tcagtacggt ttctataccc ttgaccagct tgtgcctgca gatcatttcc
     3001 tgcgccaagt ggaagctgtg attgacttcg acttcattta tgacctagta gaagatacct
     3061 attcgtctga taatggtcgt cctagtcttg accctgtcat gttagttaaa attcctctga
     3121 ttcagtgctt ttatggtatt cgttccatgc gtcagaccat caaggatatt gaagtgaata
     3181 ctgcctatcg ctggtttctt ggtttaaccc tagatgacaa ggtgcctcac ttcacgacat
     3241 acggcaaaaa ttattcccgt cgctttcaag agaaagggtt gattgagtcc attttcacgc
     3301 atattcttgg gctgtgtatc aatgcaggcc taattgaccc gacggagatt ttcatagacg
     3361 gaactcatat taaagctgcg gccaataatc gtaagtttat caaccaagag gtggaaaagc
     3421 aggccaaatt catgagtgaa cagctggaaa tcgaaattaa tcaagatcgg gtaaagcacg
     3481 gaaaaaagcc gctcgggccc gccaaagagc cagagcccat cgctaagaaa atctccacaa
     3541 ccgacccaga aagtggctgg ttccacaaag gtgatcataa ggaagttttc gcttattctg
     3601 cccaagttgc ctgtgataag tatggctggg cacttgctta tagtgttgag gctggtaata
     3661 tccatgacag tcaggctttt cctgcacttt tcgccaagct tgaacccttg aaaccagagt
     3721 atatcattgc ggattcgggc tataaaactc ccagtattgc caagtttcta attgataagg
     3781 aaatcactcc tgtccttccc tacacccgtc cccgtgggaa gaagggtcaa cttcgtccta
     3841 aagattttgt ctatgacgaa cacttcgatt gtgtcctgtg tcctgaacat caggccttga
     3901 cctatcgcac gactaccaga gaaggctacc gagaatacaa aagtgatcct gcaatttgtg
     3961 ccaactgtcc cctattatca gtatgtacga ccagtaagaa ccatcaaaaa gttgtcacgc
     4021 ggcatatttg gaaggagtat ttggaacagt gcgaggatat tcgtcatcaa agagggatga
     4081 aggagctcta ccaacatcgg aaagagacga ttgaacggct atttggcaca gccaaggaat
     4141 accataatct gcgctacacg agagaaaaag gcaagtccaa aatggaggat aagattggac
     4201 tgactttggc gtgcttaaat ctcaaaaaac tagctaaaag gatggcaaga aggccttttt
     4261 attttgtcca gatggggtgg tttcagcatt aaaacagcca tttttctcta aaaacagtaa
     4321 aaaagacaaa caccaaaacg atgtttgtct gcaatctgaa agcacttgca ggtgctttag
     4381 cgttttttcc caggggtctg agaggggtag agggcatcaa gatagtgaaa aatctcttta
     4441 cgaatatagc caaacgattg gtcttcactc gtatcaatca ccccaaagac acggtagtga
     4501 ttgcggaaga gttcttcgta gtcaatatct tttccgatga taatgatatt ggcaagctcg
     4561 gaacgttgtc gaatatccct gaggaagaag tgcattttct cagaagacaa ggccctggac
     4621 ttgacaatga aataggttgt aggcttccaa gaattatagg gctcgtaacc gagtttggtc
     4681 ttcacggcaa accactgttt gcgagcaatg agaaataaat ggataataaa gcttgtaagg
     4741 tagctagtaa tagagtaagg gaaaatttca atcatgtgta cctcctgttt ctttcttgct
     4801 tccatcttat caaaatgctt ggttttttag ctcgccaaat cctgaacagt cactgaatcg
     4861 tcctgaacgg taaaaaaacg aacagttcag gactgttcaa tgaccattca ggaaatgtct
     4921 aattcttttt tcaaaaatga gctatactta atttgtcaga gttgcaactg gacaaaaaca
     4981 atacaatgga ggtattcaac atgaatacaa aaataatgga acgatttgaa gaactaagga
     5041 gtgataaact tctaactatt gaaggaggtt ttccttgggg gactcttttt agcggtgcaa
     5101 ttgatgccat ggacggagga ggacagacct tggatcaatt gaatggaaag tggcctaaaa
     5161 gaaaccctcc acgcccttgt actccatttg gaacaggagg cacacctaat gcttgtaacg
     5221 gactataata tccaagacaa tcctgaatca gagatagaaa tctggcaggt ttctaaaagc
     5281 ggaccacaac ctatctgggt ccaagaggct tttgccaaac actactttca atggctagac
     5341 aatcgcctgc gtatccttgt tgctggtctc aacaaggaat ggtggcatca atctggcagg
     5401 tattatggtc aagggatgta tgttttagca gaaattggcg atattgttga taaaacgcac
     5461 tgtagaattt ttacagagaa acaatttcaa aaacagtatg gtcagaaagc ctagtcctca
     5521 ctctctaaaa agtcttcatt tgacgatgaa ggcttttctt tgtaccagta tttaggagcg
     5581 ttttgcacat tttaaaatgc atcgactttg tattttgtga tacaataggg aatacgaacc
     5641 tccggttttt acttctagca atcttatcag tagacttgaa tgtttaactg gccaaatcct
     5701 gaatggtatt gttttaccat tcaggacgat ttaacgaccg tttaggaaat ggagtctctt
     5761 ttcttctgtt ttatagtatg cttacaggag aaggaggtct gattatgccc tttttgatga
     5821 ttcgaacggc taaggagtgg ataaaactcc cgctggatca agtttacgat attaccagtc
     5881 accctgacaa agctcactat gtgcgaatca agacagcagg aaagtcctat gatgtgcttg
     5941 atagcctcag tcgtctggaa aaagaataca gcccagtctt agtccgctgt catcggaatt
     6001 gtctggtcaa tctctcgaag attagggaga tagatgtgga aaagagagcg ttgatactag
     6061 aaagcaatcg tcccatcgca ttttcaagac gtcgctatca ggaactgcga caattatggt
     6121 tgaacaaagg agaagaaata agatgatgaa tgtatttgtt ttagaagatg attttgccca
     6181 acagtcacgg attgagtcaa tcgttggtag tttaatggag cgacaccaca ttcagactaa
     6241 gaagtttgaa gtttttggga aaccagacca gttgattcgg gcagtagagg aaaaaggagc
     6301 tcatcaactc tttttcttgg acattgagat tcgagcagat gacaagaagg ggttagaggt
     6361 ggctcaacag attcgtgata ttgatccctt tgccattatc gtttttgtta ccactcactc
     6421 cgagtatatg cctctggcct ttcgttatca ggtatcggct ctggatttta ttgataagga
     6481 gctagccccg gccgagtttg aggcacggat tgagacagct ctcctttatg ctaatgggaa
     6541 aaatagtcgg acggtggcag aggattcctt ctattacaag tcgcgttatg cccaggtcca
     6601 agttcccttt gcggatattc tctatatcga aacctctcct catccccatc gggttattct
     6661 gcatacggag aaggatcgct tagagtttac agggaatttg gcagatattt tgaaacaaga
     6721 aaaaagactg ctccagtgtc atcgctctta cttggtcaat cccaataatg tggtcaaggt
     6781 tgatcgacag atgaaagttc tctacttccg aaatggtagc aactgctatg tcgctcggaa
     6841 tcgaatggag ctagttcata atgccattcg agacttgcat agataggagt agctaatgag
     6901 ttttctattt tttgtgatag caattgtagt gatgtttgtt ctcccctatc tttcgattgc
     6961 ttggataagt ggtcggaagc tcccctggac ctatcttgcc cttggttttc tggtggattt
     7021 ggggttgaat atactgacca tagtctatcc agacctagca gtaataacct tttcgtcgga
     7081 aataataact aaattgctag tatcctatct attgtttgga aaagagtcca aaaccttggc
     7141 agtcttctat gccttcttta cctctatcct gttcaatctc tttcatcgta gccttgtctt
     7201 ctttctcctc cccatgtttg gctgggataa agaagtccta tgggagcctc ttgggcgaag
     7261 tgtatcaggg atagtgtgct gggcactggt cttcttcttt ttgaagtggc tgggatatga
     7321 cttttcacag ctatggtccc gaaccctaga tgagaaagat aggaaggttt tgacagtcac
     7381 caattacttg atgatcggct atttcttcct taatcatatt ttgatttatt tggagcaaat
     7441 ctatcagatt gatacggtcg tgtatcgcca gtttatcgtg gtagtctacc tggtcttatt
     7501 catgggggtt gtctaccagt tggaccgaca catcaaggaa cggttgcagg ctgccttatt
     7561 gcttcagaag gagcgtcagt tgcaagatat ggagcggtac agtcagcaca tagagggact
     7621 ctatcgagaa gtgagaggct tccgccatga ctatgccaat cttttgacaa ccttgcgatt
     7681 gggaatcgac aatcaggacc tgtccttgat tgaagaggta tatcagtcag ttttcaaggg
     7741 ctctaatgcc tcttttcgtc atcaaaagta tgatgtgggg cggttgattc atctggacaa
     7801 tccagccctc aagagtctct tggcggttaa atttatgcag gctgcagaac aagggattgc
     7861 agtttcctta gaggtaccaa accctatttc tcccaaaggg atagagctgt tagactttat
     7921 cacgatcgcc tctattcttt gtgacaatgc gatagaagcg accatggaga ccgagcaacc
     7981 aagtatgagt atcgcctatc tctccttagg tgacaagcaa ctctttatcg tagagaatac
     8041 gactaaggaa gagtcggtcg cccttgctaa tctgacagat tttggtagga gtagtaaagg
     8101 agaagggcgg ggaatcggtc tctacactgt cagggagatt ttgaatggct acctcaatgt
     8161 ctcgctaaat accagtagtt gcaaccatac cttctgtcag gttctggaaa tcatggtaga
     8221 gaaatgaggg tagagctgtt gaacttcttg gtgccactaa gaaaacggcc tacttggttg
     8281 ttaaccagct ggctagagat aagtgaagga tgattcagtt cttgacttag tgaccggagt
     8341 ctagattgct gattattgca catgacaaat agttaaaagg cttgaacctt tcgtttcaag
     8401 cctttttgtt atctaggtga tttcctaccc ctgtttacgc ttaccaggga gagcgatatc
     8461 aaatggtttg ggaattaact taataaagtc tgtccaccag tcacctccta tgatagactg
     8521 caattctgtg tcggatagct gtgtaaatga tgtgttgtgt ttttgtttgt ccatgattgg
     8581 acctcctttt ttcttgttta tgttattata aacgaaaatt ctcaaaaaat cttccccata
     8641 tcctaaatgg tcgttgaaac gtcctgaatg gttaattatt tgtgtgaagc agtttatctt
     8701 tgtagtagtc gaagaaggtc ttcttagcaa tcacactggt gacgcgaccc tgtagaccat
     8761 actgtagaag tgagctttca ttttctgtaa tggtagcttg ggctgtaatc ttaaagagat
     8821 tgccctcttc tgtcggtgtt gcggattgag cgatagactg gatggagccg atgactatga
     8881 ttggctgatt gccgattttc tctaagctta gtcgggcggt ctggccttct ttgaggaggg
     8941 cgacatactc cgaagtcaca tagtaggtga taaggacggt cttggtttgc ttgatatcag
     9001 gatagagata ggcgatatcg ctccctactg gaatcaagtt ttttccctcg aactcaggat
     9061 ttagggcgat gacaccattt tctggagcgg taatggtagt ttgttctaat tgagtagctg
     9121 cttgatcgag ttgcgacttt gcctgaagca attgagattc gacagtggtc agttgctgag
     9181 ctgcgttttg tagaaactgg gcacgtaaac tttcgatttt agtcgctaga cttgtgtcgt
     9241 aggtggcgat gctaccagta cctgcccgtt gaatagagag gctagccatt gagttttcca
     9301 atcctgcgat ggtttggtta atctggctga tgtattgatc actaagggca ggatttggtg
     9361 ttccttggag ttgggctagg tagttgttca gagtggcctg gtggggattg cctgtcggca
     9421 agctacttgc ttgggtgcta atcgctgttt taagctcctc gtaggcgatg atgtcctgct
     9481 ggagttgact gagttgttgg tcaatagcag cagcggtgtg attggccaaa gctgcttgat
     9541 tagtgacctc ggcattcgtt ttagcgatac ctaattctag gtcttgtgtt tggctgacga
     9601 attgctgaaa ggttgctccg tagccaaagt tatcttctcc tgtaaagagg ttggtaccct
     9661 gttcaagact gtttcgtaag gtctccaacc cttttttctg ctcttctagg ttatgaactt
     9721 gactttctaa ggcttgcttc tgggaagcct ccattgtttc ggcgtactgg atgagagcat
     9781 cgcctttttt tacggcttga ttggctacga gatgattggc aagaatagga ttgttactgg
     9841 ttgattgaat ggaggcgatg accttggtag gagtaatctc tcctcgtgaa gtgacagtga
     9901 cttctttttt agctaggaag gagaagagaa aaaggaagga gaccagtagt accaagggga
     9961 gaatcaaaag ggtcgcaaaa ttatggtagc gtcgctgata aaattcagca cttcgaaata
    10021 ggtttgtatt cataaaaact ccttacttac tgaacaaatg gtgatagaaa ccgccgcgag
    10081 acattaattc ttggtgagag ccggtttcaa taatcttgcc ctggtccagc acaatgactt
    10141 ggttggtacg ttcggaaatg ctgagacgat gggcaacaaa gataatggtt ttgtctgtca
    10201 tggccatgag gttgtcaatg actttctttt cggtgagaac atccagcccg ctagtcgctt
    10261 catccagtat aagcacaggt gccttggtca agagggctcg tgcaagagca atccgttgtt
    10321 tttgcccgcc agatagacca gctccgtcag aaagctcagt ctgatagccc attggcatct
    10381 gttcaatatc cgagcggatt tctgcaattt cacaggcttt taggatatcc tcttgactga
    10441 tagtttggtt ggcaccgaga gtcagattgt ccaagataga gccactaaag atataggctt
    10501 gttgggggag gtagttgatg tattggcgta ggactttctt atcaaccatt tttagatcgt
    10561 tatgattgag cgtgatgcgt cccttatagg gttcaaaaaa gttcacaatc attttagcta
    10621 gtgttgtttt tccagaacca ctgataccga ctaaactaac cttgtcccct tctttgatgg
    10681 tcagttgaat atcagatagg gtgtctcgtc caaatccgta tttataggaa acatcttcaa
    10741 actgaataac tccttttaag aagcttggat cggttagggt ctgtccttct tgaaattctg
    10801 actcaaccaa gtagacttca ttaaggcgat tgttggcaac tttggcagat tggagcttgg
    10861 tctggaggtt gatgatattt tccaagggat tggtgaagta agagaggagg gtattgaagg
    10921 tgatgagttg tccgatagag atttttcctg tcatgactag ttgagagccg agccagagaa
    10981 tagtaatgtt gaggatcagc tgggctcctt gcttcagagt ggattgcagg atcgaatact
    11041 tgctgagggt aaaggatttt tccagataat ccacaaattc gctgtcaatc ttttggtagc
    11101 gttgttcttc gcttgtcaat gacttaatgg tctcaatacc attgatatct tcgataatag
    11161 cagagcttac catcgaatta ctctgcataa cagcgttgtt cattctttca aagggtttga
    11221 taaaggcaaa gatgatgacc acgtagattg ggattgaaat cagtgagagg aggaagaggt
    11281 gcgtgttttg taccaataag accccgccca caatggttaa aatagtcaca tctaggaaga
    11341 gggagaggat tgtagaggct agggcatcga tgattgagtt ggcatctgta aaacgagaga
    11401 tgacttcacc tgttcgccgt gtcgcaaaga aggacatggg gagtttgaag atatgtcgga
    11461 tataggagag aatgacatca atgctgagcc gttgactgag aacagttaat aggtagtctc
    11521 tggagaaggt catcatttgc tggagaatat aggtgataat cagtccgatg gagatgatgc
    11581 cgagagtgga tttcatctgg tttggaatgt attcatctaa aatcccttgc agatagtagg
    11641 agccagcaat gttgatgagg gtgacgagta agctggctag aacgatataa aagataagtg
    11701 ttcgttgttg gaagatgagg ggaaggaagt cgagcagacc atttttctta tccttgtgcg
    11761 gtttatagct cggttcaggt gcaagaaaga tggctactcc tgtccattcg gaagcgaatc
    11821 tctccttgct catcttggta acttttacag tcgggtcggg atcgccaatg aggacctgat
    11881 ctttcaaatt tttatagacc acatagtaat gctggagttt tccctcttta ttgacatgga
    11941 caatgaaggg ataaggaata tcagtcatat caaagaggct catatcggct tggatagccc
    12001 tggtttcaaa gcccatttca tgtgcagctt tcacgatacc gagggctgtt gttccttctt
    12061 tattagtctt tgctaactct cgcaagtggg ccaaggagta gtctgagccg tagtatttgg
    12121 cgatagaagc gagagcagcg actccgcaat ctcgggcatc tatctgaggg acgaaggttt
    12181 tctttatctt ggtcatatct agtttccttt cctattgaac taaaagtagt ctagtagcat
    12241 tatgtcatag atttaagaaa ataagcatcc aaatcctgaa cggtcgctga aacatcctga
    12301 acggtttctc tttcccgacg gctgttcttc ctgggcggtc acaaaaaagt cctgaacggt
    12361 catttctttc ccattcagga cgattggacg acagttcagg aaatggagca gtatttttct
    12421 aaaaatcagc tatactaaac ttgtcaaagt tgcaacgaga cacattcaaa aaaataaaca
    12481 taaaaaagga ggtgttcgat atgaatacga aaacaatgga acaatttgaa gtgatggatg
    12541 ttgaaatgct tgcgagcgtt gagggaggat actcagccgg taaatgttta gctgatattg
    12601 gttggggaat ggttgaagga gtagttaccg gtgcaatagc tggaggatta atgggcgcag
    12661 gaatcggatt tggactagga cagattggtg gtagcattta ctgtattgga aatgtattgg
    12721 gggggaaata atatgaattt gctagagaat ttacctgatc aaactttaga acttacaacc
    12781 ggtggtggaa gtgtaaactg ggttgttgct ggtacacaat gtcttggtgc aggagtaatt
    12841 gggctaattg gaggaccatg gactgcatta ggtgcttgtg ttattagtgg aggaagatca
    12901 ataactggag acttacttaa ttgattttaa aagatatttc aataatcatt tttagtaaca
    12961 ccttttcata ttttatagtg ttatttatta ttcatgtaat tagttattct aaaaaaaatg
    13021 tggaaatctt aaaaagatct agattaataa ttggggtgtt tgtgctgtta aattttatcc
    13081 gagatatcat acaatacttt tttatgtgat agtattgtga aatatagtgt aagtgagtac
    13141 tcatagagct acaactttcc ataaattgta agtaaccgca tgaacatgtg ataatctgtg
    13201 tatgaaatgg aagaaattta tggaggttgt tctctgggag gtctaacgat atcagttgta
    13261 aaaggtggag gaaacccaac gaaaacagct gttagtgcag ggatatatgt attaacatgt
    13321 tggtggtaat gctaaattgt actgtttatc atctatgtag catataagtg attagaagtc
    13381 tgatgtaact aaacatttga aaggtgctaa aatgagaaaa gattttatgc aactaagtga
    13441 atcaaaactt agtgaagttc aaggtggtag ccgagatagc tactgttctg gtcaaattgc
    13501 ggcgcgtgtg atttttaaga gattactagg tcaggtaatt ttaccaacgg atttaatatg
    13561 tcagtaagtg taaaggagat tcagtcatga agcaaattca atttagagaa ctgtcggaaa
    13621 tcgatttaga agcaaccaat ggtggtgatt ggttgaaaga tgttggcgac tactggagtg
    13681 gtgttattga tggtataaag gacgcatttg gaattcgtcg aaaatagagg tggacaaaga
    13741 aatggtagag agtgataaga gtgtaagaca gtatattccc ttgttgctga ttctcctagt
    13801 atatccttat ggaattggtc tagttgcaag agaatttgtt gcggatgccc tcgtattcgt
    13861 gacagggttg gtgaccctct ttctcttgta tcgacaaggc tacggagata ttttggtctt
    13921 taggaaacct acatggaaaa tagttagaag ggtcattttg gcatttctct gtaagctgtg
    13981 ttgggctgtc attgtctatc atttcctatc ctctactaaa aacgaagaag ctctggatag
    14041 ttggagttat acaggagtcc agctcttcct ttataacctc tatcttcttg tttacggtcc
    14101 aatttgtgag gagcttgtat tccgaggcta tatgatgaga agtttggcac ctgtaagtca
    14161 tctacaacta gatgtattgt gctcagcctg tctcttttct ctcggccatg ttttaccaac
    14221 tggctgggtg ctgaatgact ttctggttta tttgggctcg ggattgattt atgcaatact
    14281 ttttaagaaa tccgcaacaa tttatccagt catcattctc catatcatgt ggaatagttt
    14341 gatggtcttg tagcaaacaa aaaggaaaag tttggagtcc agatagatgc tgggcttcat
    14401 ttttgtattt gtaaccattc aggaagcctg gacgacagtt caggaaatgg gcaaacgaag
    14461 atgcgattac ctgctatact gatgctatca atgacaacat atggaggtta gaaaatggaa
    14521 acgagagaga aaatcatgga agaactaatc aaccttatct tgaatccgac cactacggca
    14581 gaggagcgga aactcttggt cgcctataaa caggaatttg aacggaccag agatacagag
    14641 agaacaatcc tcgctttagc ggagagcatt cgaaagttgg ctgttcgcaa tgttttctat
    14701 agaatcagcc tctcccctgg cctaagtcaa ttttataaaa aaatatcagc ctatggagag
    14761 tgggagaaaa atctgggtag aggtctcatt gctacaggaa tcattcgata aatagtagga
    14821 agtcatcctt ggattttgtc aggatttgca ggcctcttcc attcaggacg cttggatgac
    14881 cattcaggaa atgggcaaat catttggaga aaaatctgta caataagcct ataaagaaaa
    14941 aaggagttgt agaaatgaaa aagaacttac ttgccagttc ccttgtttgc acgattgttc
    15001 ttaccagtct tcaagggagt gtgattcagg cagagacgac tgggcaagca gactcttcac
    15061 cagtggtgac ggaggttgtg cagccgacag aagagaaaga aggaacagca ccaacttctg
    15121 aaaccgaaga gacggcggag acaactggat cgtcctcaac tgtaaatgag gaggtcagtc
    15181 aagcagttga gattagtctg gaagactatc tggagactgt ggcagctttt caaaagattg
    15241 atatcggagc agtgcgagca gcatttacag aggacaatca ggaacacctt ctgtactttg
    15301 ggcgtgggac ctgttattac tgtcgtcaat tctcccctga gttaaagaac ttgcatcaat
    15361 tgacaggtgg aaaaatagag tactatgata cggcagggga agactttgat gatactgcca
    15421 aggaatttct ctttaaggaa gtaggaatcc caggcacgcc gaccattctc tatatcaaaa
    15481 atggtcaagt gttagctggt tgggtcggtg gcggtatcag tgcccaggaa ctctatgatt
    15541 acttttatct aggaaagact cctccacagt tagtagctgg tgaggagcag gctccaagtg
    15601 caactgacga acaagcccct gtggaaacag ctctgccgac tactcaagaa gttccgcaag
    15661 gtgagcaagc ttctcaggac aggcaagaag ctccaaaaga acaagggtct cctcaggaag
    15721 tagagacggc accaaaagat acacaacctt cccaggaatc acaagaggct tcgaagaatg
    15781 aagcggatgc ttctctcttg gagttgacag aaccaaatcc ttcaagagta tctgctgtac
    15841 gacaggtcaa gcctgtttta ccaacaagcc ctgctcagag tgcagggaca aagattcttc
    15901 cgaaaacagg cgaggcttct tcggaaattg gttggcctat gggcttactg actctcatgc
    15961 tcgctcttgt catacaagga ttagcgatta ttcataagga ggctgaataa tgaaacgttt
    16021 gaaaaaaatt gccctatttg ttggcttgat cctattaacg attgttttta atctacttcc
    16081 catgctcttc atcgggcaag aggcacagac tcctgtcgca atgaaatggg tgtttagtat
    16141 tgcctatctc gctttggttg gttttctaat tttcttgatt ggaaagcggt atagacagca
    16201 ggtaaccgag acggttaggg agttacggtt tacttggaaa gactttggga ttgctctgct
    16261 atttttccta gcaacccgtg tcgtcgcagt tttggggacc ttgctggtac agataggtac
    16321 tgggaatacc atgtctgcta atgatgcggc cctgtttgcg accagtgagc aggtagcgac
    16381 tatgtttcct ctctatttca tagcttttca tgtagctatt ggtctgtttg caccggttat
    16441 ggaagagatt gtctttcgag gattcttcag tcaatacttt ttcaagacag gcaataagtg
    16501 gttgaaattg gtgattagct caagcatttt cgccctgttt catatcgtat atccgatcga
    16561 atttgtgacc tacttcgctt tgggagctat tttctacttg gcctacgcac gtcgtggaag
    16621 tatcaaggat gcgattgctg ttcatatttt gaataatagt ctccttgtct tgttttcagt
    16681 tatcaattat ctaatcatct tatttggata gaagggagga gttggctatg aaagaattat
    16741 ccaaggctca gcttgtgagc atcataggcg gagggcaatt atccagtctt atcggtcttc
    16801 ctatagttgt caagggacca ggacgggaaa ttcctaaacc acgccctgtg cagccacctg
    16861 cggaaatcat gtaggctatt aaacgagtaa agcacctctg gttatccaaa ggtgcttttg
    16921 aaattatttg aaaaactcga aaaaaacagt aaaatagagt acggaggttt atatgaacat
    16981 cagagaatac caaaccagcg atgaaaaagg ctgggtttat tgcaaggcac tcagctatct
    17041 cttttccccg ttttttgacg atagagagac ggaaaaacca gcactgctga cggacattta
    17101 tgataagagg attgaactgg tggctgaaag tgacgaccag attgtcggct tgattgacat
    17161 cgacatttac agtcaggaaa ccagccaaac ctacctctat gctcccagcc aacgtacagc
    17221 ttacctgacc aatctcgctg tccaccccga ttaccaggga caaggcattg cccaggccct
    17281 ttatgaaaaa gcagagcagg cattgaaaga agctggagta gaaaagctcg ctatatttac
    17341 ccgagatgga gatgctgcca accatttgta taaaaaatgg ggaggacagc tgatttgtac
    17401 tgattaccta gtcatcggta cacccaaaga cacaccttat gtccgctttg gtgtcgatct
    17461 tcccaatgcc aaattggcct ttacagatga agcaggtcag ccagaaccct actatctccg
    17521 agaaggtgtc tatgtcgtga ccgaccaagc agatttagaa ctgtttgata tcgaagaagt
    17581 ctatcaggaa ctgacctatg tggtggattt ggtctaatga cctctgcgga ctaatttagt
    17641 tctaccaatt tgtttttaca gctgaaattt ttatagggct gtcactccaa tatctcattc
    17701 cgtagcaaat attcgcattc tcttttcttt t
//
