LOCUS       NZ_JAQMJT010000006     22781 bp    DNA     linear   CON 28-FEB-2024
DEFINITION  Streptococcus salivarius strain 1001095st1_G4_1001095IJ_161003
            NODE_6_length_118876_cov_18.2303, whole genome shotgun sequence.
ACCESSION   NZ_JAQMJT010000006
VERSION     NZ_JAQMJT010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus salivarius
  ORGANISM  Streptococcus salivarius
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 118876)
  AUTHORS   Chen-Liaw,A.
  TITLE     Human gut microbiome strain richness
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 118876)
  AUTHORS   Chen-Liaw,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JAN-2023) Precision Immunology Institute, Icahn School
            of Medicine, 1470 Madison Ave, New York, NY 10029, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 26.073790043805616x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/28/2024 01:16:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,217
            CDSs (total)                      :: 2,158
            Genes (coding)                    :: 2,099
            CDSs (with protein)               :: 2,099
            Genes (RNA)                       :: 59
            rRNAs                             :: 1, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 50
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 19 of 59
            Pseudo Genes (incomplete)         :: 40 of 59
            Pseudo Genes (internal stop)      :: 17 of 59
            Pseudo Genes (multiple problems)  :: 13 of 59
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:19:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 23410
            Orig. end                         :: 46191
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQMJT010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22781
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22781
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22781
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12781](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12781
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            493..1506
                     /locus_tag="PNU26_RS06505"
                     /old_locus_tag="PNU26_06505"
     CDS             493..1506
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887337.1"
                     /locus_tag="PNU26_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06505"
                     /product="ERF family protein"
                     /protein_id="WP_195918045.1"
                     /transl_table=11
                     /translation="MTENTETMVNNTNMISELIEAKVALAKAEMQLEWQKAEQAKDHSK
                     PEPEVMAPLFEALAKAQAEFGTVSATSRVTFKNVDFKFAPLSEILGAVRSALNKYGLTL
                     TQQTKHIPFGNANGIKVVTTLLHESGVSYDIESVPVFYNVNDIKNLGAQVTYLRRYEVK
                     TLLGIEADSEELDMDNVPNHSQSVQQTGNYDSNHNYQSAQAKTPRKPTGARYGKTAQSA
                     SLATSLSSSEQTSLSEMTSANNVASDSVSQATSEAESSSQKSETATLKPKGTKTVCNDD
                     QLIQMVARGEEAALSLGATESQLLEWSQIGESQGLTVQLKALSDFVSKQRQQAQQQ"
     gene            1866..2150
                     /locus_tag="PNU26_RS06510"
                     /old_locus_tag="PNU26_06510"
     CDS             1866..2150
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887335.1"
                     /locus_tag="PNU26_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06510"
                     /product="hypothetical protein"
                     /protein_id="WP_230310579.1"
                     /transl_table=11
                     /translation="MAKVNTLLKNEGHKVHLGYISLTGLEALDKRGVNSMSEMVPGKRA
                     WLIVYDDANPCKSYTNEDIRYYKEFVDLFSSRIKRRLCFEEILHELELA"
     gene            2210..2518
                     /locus_tag="PNU26_RS06515"
                     /old_locus_tag="PNU26_06515"
     CDS             2210..2518
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887334.1"
                     /locus_tag="PNU26_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06515"
                     /product="hypothetical protein"
                     /protein_id="WP_195918046.1"
                     /transl_table=11
                     /translation="MTKTEKAKWLKEHYKSYSLKWYLEDDARLNAIFRKVYNRYMSDLN
                     ARASKAQLSHIEDLGKRMREVYEDVYGTKFDSDCRLDRAETNRKVQAIRSMWVVAPA"
     gene            2531..2707
                     /locus_tag="PNU26_RS06520"
                     /old_locus_tag="PNU26_06520"
     CDS             2531..2707
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002892455.1"
                     /locus_tag="PNU26_RS06520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06520"
                     /product="hypothetical protein"
                     /protein_id="WP_195918047.1"
                     /transl_table=11
                     /translation="MDRISILLETLPRESTISFLYKGGAAIVVARDKQERLLFKVTTTV
                     AVAMQLQAEWLVV"
     gene            2727..3374
                     /locus_tag="PNU26_RS06525"
                     /old_locus_tag="PNU26_06525"
     CDS             2727..3374
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887332.1"
                     /locus_tag="PNU26_RS06525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06525"
                     /product="JAB domain-containing protein"
                     /protein_id="WP_195918048.1"
                     /transl_table=11
                     /translation="MTLTTITRRQVRHPRDFRDRELFKRAFSHWIPSEKVDALYSELQG
                     DSKKVCELSIEELKHYGLTQRDAIAFLSMLELFKRSEGEEEKPTCVTGTGYFAQSIQKA
                     YGHKKQEHLVVWYLDVHCNVIEERVVFIGSVHRSMACPREIFHYAVKNLARYVLVAHNH
                     PSGSVYPSSNDINVTEALEDAAKLFEMEVLDHVIVTKDNYYSFRDNGRMRCF"
     gene            3389..3877
                     /locus_tag="PNU26_RS06530"
                     /old_locus_tag="PNU26_06530"
     CDS             3389..3877
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887331.1"
                     /locus_tag="PNU26_RS06530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06530"
                     /product="hypothetical protein"
                     /protein_id="WP_195918049.1"
                     /transl_table=11
                     /translation="MGNISHAFGKVTISAPTLTDIEVLVATHRVINEKAWNPTTIEGSP
                     SEADCITTEEGFVSVTLPFTACGNWNIRENIDSFLTDILKQDSTLSDIPISATFDYVDA
                     ESGVNFIYKATVMTRNVPGKGVTTELLTDEDLGDYSESYLKELEGVYEQELALASITV"
     gene            3897..4370
                     /locus_tag="PNU26_RS06535"
                     /old_locus_tag="PNU26_06535"
     CDS             3897..4370
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002892450.1"
                     /locus_tag="PNU26_RS06535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06535"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_195918050.1"
                     /transl_table=11
                     /translation="MKKTLERMMAMKETFFWDFSQEDISTLSDLTSEGFEFDWSAISSP
                     NAITSGFVIQGEVSGMIEFTPEPTDYYNFIHKLEVRMDKRNQGIAGVLLAHVAQDAFNR
                     GFEGFMMLISKTALRDFYVSRYGGSRIGNTNRVIFNTAASQGLIDRFLKGGVD"
     gene            4373..4552
                     /locus_tag="PNU26_RS06540"
                     /old_locus_tag="PNU26_06540"
     CDS             4373..4552
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002892449.1"
                     /locus_tag="PNU26_RS06540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06540"
                     /product="hypothetical protein"
                     /protein_id="WP_073945594.1"
                     /transl_table=11
                     /translation="MRIVERFKEDWRSLGLPDKPYKTPEEIEMIKNGNLVWAARVEQNL
                     GRKLTPSELDEMQW"
     gene            4667..5218
                     /locus_tag="PNU26_RS06545"
                     /old_locus_tag="PNU26_06545"
     CDS             4667..5218
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002892446.1"
                     /locus_tag="PNU26_RS06545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06545"
                     /product="hypothetical protein"
                     /protein_id="WP_195918051.1"
                     /transl_table=11
                     /translation="MTTLVPTTLLLGKKLLEVNGSFSGMTLHQFLNETGNSHLFIKKDG
                     MVAINTLLEQSRLMPISCDEALVAMEDLKMTSLRSQFGFFIKPTQYKRQNPEVLVRLGN
                     NRKVVFHRYYFGNGYMANLVYQVEDDQIEFCQSSVFKSWDNGEYHITYDTPVTEDVEDI
                     NTRKELLSFLSRVEELPFIK"
     gene            5264..5617
                     /locus_tag="PNU26_RS06550"
                     /old_locus_tag="PNU26_06550"
     CDS             5264..5617
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002892445.1"
                     /locus_tag="PNU26_RS06550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06550"
                     /product="hypothetical protein"
                     /protein_id="WP_195918052.1"
                     /transl_table=11
                     /translation="MTKKIYVYKNKKAQEVFADLFAKDLLEGVTTFPRIDNAQSYSFLE
                     LSCFYLKRILEMKERKVQTLFVEGKPEPALASALLQARAMGLNVVIKLKTTESNVETQE
                     GLKELGLDDVVMA"
     gene            5641..6264
                     /locus_tag="PNU26_RS06555"
                     /old_locus_tag="PNU26_06555"
     CDS             5641..6264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887324.1"
                     /locus_tag="PNU26_RS06555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06555"
                     /product="hypothetical protein"
                     /protein_id="WP_195918053.1"
                     /transl_table=11
                     /translation="MTITQGIYYIEKVHQYNRNIAGYPSDLIDDRIASIIDSNKAEMQQ
                     SLRCRPVRNVVLNREGVSNLPPIEIPFESSLYYEVEEINPGLSKLTISTEHAKAFQEAD
                     IRMLETRLTMLQRAKECGNFTTSNYPSRFPKEARVDLSQLDLLAWGTKDMPTYLFCLME
                     SALDSYRGFYSLRDLMEDANGTLQQGYDKAVYWIYSGVKGQYEY"
     gene            6276..6437
                     /locus_tag="PNU26_RS06560"
                     /old_locus_tag="PNU26_06560"
     CDS             6276..6437
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887323.1"
                     /locus_tag="PNU26_RS06560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06560"
                     /product="hypothetical protein"
                     /protein_id="WP_181717495.1"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYGTKRDILY
                     LDLVPAGQ"
     gene            6550..6735
                     /locus_tag="PNU26_RS06565"
                     /old_locus_tag="PNU26_06565"
     CDS             6550..6735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006531554.1"
                     /locus_tag="PNU26_RS06565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06565"
                     /product="Paratox"
                     /protein_id="WP_037601381.1"
                     /transl_table=11
                     /translation="MMTYDEVMEAIERGFIKGDKISIIRRNGKIHDYVLPGEKVEPGEI
                     VEKEDLDVVLEELKEF"
     gene            complement(6913..8277)
                     /locus_tag="PNU26_RS06570"
                     /old_locus_tag="PNU26_06570"
     CDS             complement(6913..8277)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003098077.1"
                     /locus_tag="PNU26_RS06570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06570"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_195918054.1"
                     /transl_table=11
                     /translation="MNVFKKGILKFILAFLTIIFIDFVLLVATTNFIRSQQSPIDIIQG
                     VSSNITPSNGTYKVNQTAEKLIKKHNLWVMILDQESGNEKFNIKKPKNIKTQFDYADVI
                     KFSRYYLDDYPIFTQIKKEQKDIYIIAFPKESIIRYGNNFFDLKRVQIFPILILVIIFV
                     NCLFCLFLYLYSVTFLNRNIQPIINAIGKLPVGLNKQVNSVQELNRLTLAVNSANKKLR
                     KNEEFKENWISGIAHDIKTPLSVIVANTSLAIEKTDNDGLLKNLKPTLVESHYIQNLLN
                     DLNIFARLTNSNLKLNQEITDIIPFFKEIIIQIINQEIWNDFNFEFIPDNKLLGKKMYI
                     EKSLMSRVIHNLIYNSVLHNPSGCNIQIVLNYISRNKFSVIIRDNGIGTSTDRLKNINK
                     IEEFNFDISGVRRSGMGLKISNQIVDLHGGSMIITSEQGEYFQTEIILPIESPTL"
     gene            complement(8294..8992)
                     /locus_tag="PNU26_RS06575"
                     /old_locus_tag="PNU26_06575"
     CDS             complement(8294..8992)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002294154.1"
                     /locus_tag="PNU26_RS06575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06575"
                     /product="response regulator transcription factor"
                     /protein_id="WP_037601374.1"
                     /transl_table=11
                     /translation="MNFEAQLLNKRILIVDDDVSLSKSIKEVLVSRGFKNISNAYSISE
                     GIDIFSISKIDLIILDVMLPDGEGYLLAQYIRKTSDIPILFLTAKNNPDDEVKGLDSGG
                     DDFVTKPFLPKTLIYRIIALLRRAYKGESELITLTSCIIDLNNASVKKEEQHLSLTPTE
                     IQILRKLYTNKNYIVSTEAICDTIWGIDSFGYEKSLMVHIRNIREKIELSPSKPHHLIT
                     VKGLGYKLVI"
     gene            9250..9399
                     /locus_tag="PNU26_RS06580"
                     /old_locus_tag="PNU26_06580"
     CDS             9250..9399
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410306.1"
                     /locus_tag="PNU26_RS06580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06580"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_037601371.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.8e-26, bitscore:
                     84.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 2.6e-06, bitscore:
                     20.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKDVVIESIKEVSLEELDQIIGAGNGVFKTISHECHLNTWAFLA
                     TCCS"
     CDS_motif       9250..9321
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKDVVIESIKEVSLEELDQIIGA"
                     /locus_tag="PNU26_RS06580_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9322..9399
                     /prepeptide="core"
                     /locus_tag="PNU26_RS06580_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2650.0"
                     /monoisotopic_mass="2648.2"
                     /core_sequence="GNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKDVVIESIKEVSLEELDQIIGA"
                     /leader_location="[9249:9321](+)"
                     /alternative_weights="2668.0"
                     /alternative_weights="2686.0"
     gene            9428..9577
                     /locus_tag="PNU26_RS06585"
                     /old_locus_tag="PNU26_06585"
     CDS             9428..9577
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410306.1"
                     /locus_tag="PNU26_RS06585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06585"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_195918055.1"
                     /sec_met_domain="L_biotic_A (E-value: 7.6e-27, bitscore:
                     85.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 2.6e-06, bitscore:
                     20.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKDAIIESIKEVSLEELDQIIGAGNGVFKTISHECHLNTWAFLA
                     TCCS"
     CDS_motif       9428..9499
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKDAIIESIKEVSLEELDQIIGA"
                     /locus_tag="PNU26_RS06585_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9500..9577
                     /prepeptide="core"
                     /locus_tag="PNU26_RS06585_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2650.0"
                     /monoisotopic_mass="2648.2"
                     /core_sequence="GNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKDAIIESIKEVSLEELDQIIGA"
                     /leader_location="[9427:9499](+)"
                     /alternative_weights="2668.0"
                     /alternative_weights="2686.0"
     gene            9823..9981
                     /locus_tag="PNU26_RS06590"
                     /old_locus_tag="PNU26_06590"
     CDS             9823..9981
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000794682.1"
                     /locus_tag="PNU26_RS06590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06590"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_080702563.1"
                     /sec_met_domain="L_biotic_A (E-value: 5.9e-26, bitscore:
                     83.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNKIHLEALEALQELKMEEIDNLLGGAGHGVNTISAECRWNSL
                     QAIFTCC"
     CDS_motif       9823..9906
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNNKIHLEALEALQELKMEEIDNLLGG"
                     /locus_tag="PNU26_RS06590_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9907..9981
                     /prepeptide="core"
                     /locus_tag="PNU26_RS06590_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.10"
                     /molecular_weight="2509.8"
                     /monoisotopic_mass="2508.2"
                     /core_sequence="AGHGVNTISAECRWNSLQAIFTCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNNKIHLEALEALQELKMEEIDNLLGG"
                     /leader_location="[9822:9906](+)"
                     /alternative_weights="2527.8"
     gene            10001..12781
                     /locus_tag="PNU26_RS06595"
                     /old_locus_tag="PNU26_06595"
     CDS             10001..12781
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001072114.1"
                     /locus_tag="PNU26_RS06595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06595"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_037601363.1"
                     /sec_met_domain="DUF4135 (E-value: 7.8e-77, bitscore:
                     251.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.1e-56, bitscore:
                     183.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHQEQLYSQFNKFPKVFIEKKIPEVLNEDVKVLKQVEKNISDYY
                     RSTLIYLINEKRIEGKLIGDTAELRYDYFNNVLCKNGDILEEIEERFPTISQRVIISIE
                     QYLDLLKCVKKHFSIDFSILKKIKFICSDDENPNLNNLDIKVTGDIHNGSGVCILSYDG
                     QKLVYKKKSSKPNHLLKKLDNQVSKYLKKEIQFVPDFLDREGYFWETFIDSKPVCSIDE
                     AKEFYKRMGYLVAYAYILNISDLHFENLISHNVQPILVDAETVFSVSPYETVADNNATL
                     EIIRDSRNSVLSTGLLPVSEADKIFGGDTSGVLGGTLIGEARVLINQNRDDIHVEKQKY
                     KTENQAHLPYRVGQTGLRNYLNAEDYIDSIKMGYLELSHFIIDNKEFLKQLYLSFSDLK
                     TRVLFRNTRDYSLVRQLLTSPIYCNQSNVLFEKMSDKLSNFESLNLCESEEKQLLNMNI
                     PYFYSRISDVDIKDNETIVWKLKDSALTEALKKLERFDLSIMREQVDLIEFSIKTPNAL
                     YSTELQESYKKFNNLNSDKEVLFAGINTLVDTILNNEKCSKLDGSTNWLTLKVTDYDAF
                     ELEPMDLSIYEGISGLSIALCEVYDLVNSERQEKIYNCIHRIFLTLSNSYDSVQNQSYY
                     VGKLGILSALKRIQLITGQKISKSILDRNKDYSLDLNVSSADFLSSFPNEIVALYRSDL
                     SIKNLRQALDKLIDLKINYENYIAWDNLESNNVSLAHGNLGIELALHYIAGILDNSKAL
                     EMLFQANNFDNRQKISQGWIDKRNNSTSANWCHGSTGVLVARLAQLELDKKFQLIPSAR
                     RKELEADIRHAVSQIIEVGFNMTNFSICHGTSGNLLALNYYRSYLKGHEAQELEKILEI
                     EYRKLHSFGLENGWMCSFNTKYNVYGIMNGLSGILYSTAKYIKRDNSLDLLIPTL"
     gene            12808..14880
                     /locus_tag="PNU26_RS06600"
                     /old_locus_tag="PNU26_06600"
     CDS             12808..14880
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268663.1"
                     /locus_tag="PNU26_RS06600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06600"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_037601360.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.5e-38, bitscore:
                     122.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLQNNEEDCLLACYTMLLNDLGHKVPLYEVYNKDTLPADGLN
                     VSYLLSLNERFGVTLNAYHATYEDICKIYKEQKRRMILHWNNDHFVVLEKITATQVMIV
                     DPAIGRVKYSYEEFIKHYSKTIVLISKSKNFQKQKYNQIFWKYFIQTLKTKTIILFLVS
                     LVLIQISVLIFSVVLRYMLAEKFKFWASIILLAGVVLFQLFGYFIKNNALDEYNLDFDN
                     NYSRILFEKLLKKPLLYFRNHLSGGISEKINFKSTLRDNVTLKIIPSCVSFISAIVIFI
                     YLMTISVKLTVILVTMISAYSIISIFLYRKQNEYNQTYLQYLIDFNSELQMDLDDIDYI
                     KIMRREGLTFSSWMDINKKVTEKYSQILKFENLTQLIGTIFNYISLSVIIIVAVYYENY
                     IHVSISDLLVYQTSISLLVSAIEQVKGAAFEAIRLGVYAEKQSDLLKDSKPILVQSSSS
                     DEYLIKAEKLNFSYGMKPIYNDIDLTIGKGEKVAIVGKSGSGKSTLLLLLAGMLRYNGS
                     LKYGIENFEECLSVVLQNMTLRKGSVLENLEWDSDDLTPLFQVLKDTSADEVINQLPNK
                     VHSKLLKQGKNLSGGQIQKLLIAKSLLKNEGIIFWDEAFSNLDEQSKNKIYTNILKNSN
                     YSKKTMLMVSHHLDIVEYVDYIIYIDDETGKVYKDTHSNLIKTNESYFNFINSKV"
     gene            14987..15895
                     /locus_tag="PNU26_RS06605"
                     /old_locus_tag="PNU26_06605"
     CDS             14987..15895
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263495.1"
                     /locus_tag="PNU26_RS06605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06605"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_037601358.1"
                     /transl_table=11
                     /translation="MNNIIELKNLKKVYKDTTTVDLKKLTVREGEIYGFLGPNGAGKTT
                     TMKMILSLVEPTLGEILVNGQNIKEDNDYLNQIGSMIEEPSYYPNLTGYENLLVFQKMV
                     GFDEDNIWPTLKLVGLAEDKNRKKLVKAYSLGMKQRLALAFALVKKPQILLLDEPTNGL
                     DPAGIHEIRELIVKLAKEEGLTVFISSHILSEIEQIADRVGIINHGCLVYEGEIREIKS
                     NTWIGIGGDFSQNNIVQHLVDFCSVKVREASASEVKLDDMSNDRLADIITYITDLGFRI
                     FRVTRESETLEDIFLELTKEV"
     gene            15897..16640
                     /locus_tag="PNU26_RS06610"
                     /old_locus_tag="PNU26_06610"
     CDS             15897..16640
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943276.1"
                     /locus_tag="PNU26_RS06610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06610"
                     /product="ABC transporter permease"
                     /protein_id="WP_037601355.1"
                     /transl_table=11
                     /translation="MKGVYIEWLKSRRTKSFSIVTLLMIVATLWSIAMFMSAFSHPELK
                     NVGTLFSNQNVNLLMLPIAVSVFVSRIVSNEREGQTFKLQATNGLGLMTIFRHKFLFTM
                     VFFFVMSFAEIVAICCFGKQSGISIPMDIVGVQFLGQLLSIFALVSIYLTLAMVLEKQG
                     VLLALGLLGGFLGIVLNPRSYGFASLLNPLTGAGSLAPYKYHFLGDGAYTYLLDQQLPW
                     KLVFFMIYCLMLYGLANVILRKRGS"
     gene            16642..17376
                     /locus_tag="PNU26_RS06615"
                     /old_locus_tag="PNU26_06615"
     CDS             16642..17376
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943275.1"
                     /locus_tag="PNU26_RS06615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06615"
                     /product="ABC transporter permease"
                     /protein_id="WP_037601352.1"
                     /transl_table=11
                     /translation="MRPYVFAEWKKTRKLQLFMIGMAFLVFSSFIGLGAYFANRAVLID
                     KTQSLVLWGQLTFYNSTLLYPPMLAIIVGQLLMPEFERKNIEMLKANQVSMDKLYFGKL
                     LSGFFLILSVQLFLILIFVVAAKVDGISFDLSLAVHIKWLLLSVVASFPIMTLQSFVTA
                     KTRNFSKAVGVATIGSMLNFVLIFINENLTKFFPYSQPMIALRSRSLTDMSLIDLTIFL
                     VVNSLYSLLFYKLTVAALKKNE"
     misc_feature    16666..16682
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 23.28"
                     /tool="antismash"
     gene            17662..17817
                     /locus_tag="PNU26_RS06620"
                     /old_locus_tag="PNU26_06620"
     CDS             17662..17817
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002982773.1"
                     /locus_tag="PNU26_RS06620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06620"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_037601350.1"
                     /sec_met_domain="L_biotic_A (E-value: 3.8e-19, bitscore:
                     61.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 2.5e-07, bitscore:
                     23.5, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAMKNSKDVLNNAIEEVSEKELMEVAGGKKGPGWIATITDDCPN
                     SIFVCC"
     CDS_motif       17662..17748
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIAMKNSKDVLNNAIEEVSEKELMEVAGG"
                     /locus_tag="PNU26_RS06620_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       17749..17817
                     /prepeptide="core"
                     /locus_tag="PNU26_RS06620_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.40"
                     /molecular_weight="2314.7"
                     /monoisotopic_mass="2313.1"
                     /core_sequence="KKGPGWIATITDDCPNSIFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIAMKNSKDVLNNAIEEVSEKELMEVAGG"
                     /leader_location="[17661:17748](+)"
     gene            17901..19592
                     /gene="lanM"
                     /locus_tag="PNU26_RS06625"
                     /old_locus_tag="PNU26_06625"
     CDS             17901..19592
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491806.1"
                     /locus_tag="PNU26_RS06625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06625"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_328287994.1"
                     /sec_met_domain="DUF4135 (E-value: 6.7e-82, bitscore:
                     268.4, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKRDELKLEYQQHQFYEYFNSIFNYDILDTSISENIYLLRETTH
                     KLFYSEFENQLFETIMFLSMKTLVLDINNFSKEIENKSEAYEQYIQQIGEKDGISNFFD
                     RYPYLLKQINREVGLIEESYSLLFDRFLKDLSEIRLCFNITEPLSNVEFSLGDSHSKKQ
                     TVVKIEFKEKSVYYKPKSYDSYNILLELIGLLKSNNIPSFSLPESLVKVGYCWQLGVDY
                     TRSNNDEVKKIYFKYGVLAAFSEIFSITDLHMENVIVSGGNLYLIDVETFFQRKLNVQN
                     NNFEGITVDTYQRIYETSLSNGLFPVQFEKNSAPNISGISGKGGKRKKGKYELINKNRG
                     DMKLVRTDYFQEDGYNIPILNGKVVEPLDYANEIITGFRECYIFLLSQRAKTKEILEDF
                     PKLKTRAIFRNTSDYGKFLQASTNPKYLFSEKKRENLFSILYESKHIEQFIVANEIKDL
                     MNGDIPYFSMDTSGNVYNSLGTLIGNLGDTTSLFDNIATLNDERMEFTCELIEIVLKKP
                     IKHWERKEGKSYHFPSISSEQSFSEEILDSVRQIFIEANKNCFSSL"
     gene            complement(19816..21018)
                     /locus_tag="PNU26_RS06630"
                     /old_locus_tag="PNU26_06630"
     CDS             complement(19816..21018)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713014.1"
                     /locus_tag="PNU26_RS06630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06630"
                     /product="IS110 family transposase"
                     /protein_id="WP_270281696.1"
                     /transl_table=11
                     /translation="MRTVFGIDVSKASSEVAILVNGERVHGYTMPNDIIGFSHLLKDLK
                     TVSNPEIIFEATGVYSRRLQAFLEENSYDYTRLNPLEAKKQLDGLRVRKTDKIDAEKLA
                     SSQFVLNRMPTYVQEKVYQNLHDLSRFYQNLTEDIVRTKNRLHKVLQVAFPEIEILLST
                     PAGEQYWNLVSIFPTKHWVLELSEVELKETIRQSTSKRISENRAGNLAEKLVGLAKQSY
                     SAISKTSPMIEEVKYNAQELIRLTNRREQVLEQLIELAKPLPEYEILLSIPGIAETTAT
                     SIIGELGDIRRFQSTNQINAFIGIDLRHYESGNFLAKEHITKRGNPYARKILFKCIHNI
                     ASASHTNPCHIADFYEKRKRQSQTTSTKPHTIASIHRLIRTMYYLIMHNKLYDYTLAQS
                     H"
     gene            21321..21476
                     /locus_tag="PNU26_RS06635"
                     /old_locus_tag="PNU26_06635"
     CDS             21321..21476
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PNU26_RS06635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PNU26_06635"
                     /product="hypothetical protein"
                     /protein_id="WP_195917972.1"
                     /transl_table=11
                     /translation="MATTTIFFIKTITFLEKKLWRRRRKTTPPYSSPEGKNNDLYPGKI
                     LNTLLV"
     gene            21592..22674
                     /locus_tag="PNU26_RS06640"
                     /old_locus_tag="PNU26_06640"
     CDS             21592..22674
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887312.1"
                     /locus_tag="PNU26_RS06640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PNU26_06640"
                     /product="hypothetical protein"
                     /protein_id="WP_230310569.1"
                     /transl_table=11
                     /translation="MVEFKDYENTQELEGWYNWPVRASKKIKSIRAINSVISYFRRHRL
                     KRTLIISYTLLGTMVWTATTGYFSPKRVTYTDTQLRATQTFGNGLGSITATSMTYSPSN
                     GMVVMELATSDATSAIQKGINTENLDWQVFLPSSVKNSEAVTLEVIPLTGDKVYLVLRN
                     VPSDYTLMVIRVTNKTPNSNSLKLDVQEYDDYLSSSSNSVSNQKKQKDTDANKTYVDFF
                     VTPQNELLKNKYVKNLSREKFALNIFEEELKYQKGQRKELLNSAKTLDDSIKEDTKTLE
                     QLKRESEYLVGNELTDKQSDMEAIEKSMDSKEKDGAKARENAAYVQTIIEQIEKNIKAV
                     KNGTYKFNSPVRSVKQDIGE"
ORIGIN
        1 attcccttca agtgcaaaat tgatagtctg aatctttcag gcggttattt catagacctg
       61 aaaacgatgg agagtcttca gtcggaaaaa tattcgacga cacttcatcg ttatacgaag
      121 tctcttctct ataacattgt agaatatcag tatacgctac aaatgtacgt atatcaggag
      181 ttgctgaagc aaacctacgg ttatgagttt acaccttata ttatggcagt ttcaaaggaa
      241 cctgttccag ataaggagtt aattctgatt gatgatacta tcattgaaat ggggggagac
      301 atcttctatg ggcatcttga agtacttaaa gatgctttag cacataagtc tgtcgaagga
      361 tgcggtcact gtgattactg tttaacgaat aagtcgttaa caacagcaaa aacagtggca
      421 gaatttttac aacaataaac aggaacacag tggtttaaaa aagccacttt ttaacattta
      481 aggagaaaaa caatgactga aaatactgaa actatggtaa ataacacaaa catgatatct
      541 gaactcattg aggcaaaggt ggctttagct aaggcggaaa tgcagttaga atggcaaaag
      601 gctgaacaag ctaaagacca ttctaaaccg gagccagagg ttatggctcc attgtttgag
      661 gctttggcca aggctcaagc tgagtttggg acagtatcag caacaagtag agtcacgttt
      721 aagaacgtgg actttaagtt cgcccctctc tcagagattt taggggctgt acgttcagct
      781 cttaataagt atggtttaac attgacgcaa caaaccaaac acattccgtt tggtaatgca
      841 aacggaatca aagtcgtgac aacattacta catgaaagtg gtgtctctta cgacattgag
      901 tcggttcctg tattctataa tgtcaatgac ataaagaatc taggagctca agtaacctat
      961 ctgcgacgct acgaggtcaa aacacttctt ggcattgagg ctgatagcga agaactagat
     1021 atggacaatg tgccaaatca ttcgcaatca gttcaacaaa ctggtaatta tgatagtaac
     1081 cataattatc agtctgccca agcgaaaaca cctcgcaagc caacaggtgc ccgctatgga
     1141 aagactgctc agtcagcgtc gcttgctact tctttgagta gtagtgaaca gacatctcta
     1201 agtgagatga catcagctaa caatgttgca agtgatagtg tatcacaagc aactagtgaa
     1261 gctgaatcat cttcacaaaa gagtgaaaca gctactctaa agccaaaagg gacaaaaact
     1321 gtttgtaacg atgatcaact gattcaaatg gttgctcgtg gtgaagaagc agcactgtct
     1381 cttggagcca cagaaagcca gttgcttgag tggtctcaga taggagaaag ccaagggttg
     1441 actgttcaac tcaaagcctt atctgatttt gtttctaaac aacgtcagca ggcacaacaa
     1501 caatagtaaa aaagtggtca aaagaccact ttttatatta aggagaaaaa aatgacacaa
     1561 attacagagt tattcaatac taatctaagc tatactcaac aacagcaggt atggtatgaa
     1621 ttctttaatc aaacactccc agagtggttg ttcatcggat tcgtggctat actttgctac
     1681 gttatcttgt gtaacttact tcgaaataaa ttaattttta agttggttgt agcaatagta
     1741 tttctgatcc cgattctctt tgtagaaggg attcagcatc tgtttcgaag ttgagaggag
     1801 aaaaaatgat aaatgtatta tgttttgtag atggagtgaa taagccaaat aaacatacta
     1861 aatgtatggc taaggttaac actcttttaa aaaatgaagg gcataaagtt catctagggt
     1921 atatttcact cactggacta gaagcattgg ataaacgtgg tgtcaactct atgagtgaaa
     1981 tggtaccagg gaaacgggca tggctaatcg tgtatgatga tgccaatccc tgtaagtctt
     2041 atacgaatga agatattcga tactacaagg aatttgtaga tttattttca tctcgtatta
     2101 aacgtagact ttgctttgaa gagatccttc acgaacttga acttgcttaa ataatagcaa
     2161 caacaaaaga aaaatggtcc tagggccatt tttttagagg agaaaaacaa tgacaaaaac
     2221 tgaaaaagcc aagtggttaa aagagcatta taaaagctac tcactgaagt ggtatcttga
     2281 agatgatgcc agactgaatg cgatttttag aaaagtctat aatcgctaca tgtctgacct
     2341 caatgcacgc gcttcgaaag cacaattgtc tcatattgag gacctgggca aacgtatgcg
     2401 agaggtatac gaagatgtct acggtactaa gtttgatagc gattgtcgct tagaccgtgc
     2461 agaaacaaat agaaaagtgc aagctatccg ctccatgtgg gtagtagcac cagcctagga
     2521 ggaggtagtt atggacagaa taagtatcct actagaaaca cttcctcgag aaagtaccat
     2581 ttcgtttttg tataaaggtg gtgctgctat tgtagttgca agggataaac aagaacgttt
     2641 actctttaaa gtaacaacaa cagtagcagt cgcaatgcaa ctacaagctg aatggcttgt
     2701 ggtttaacag gtaaaggaga aaaacaatga cattaacaac tattactagg agacaagtaa
     2761 ggcatcctag ggattttcgt gatagagagc tattcaaaag ggctttcagt cactggatcc
     2821 cttcagaaaa ggtggatgcc ttgtattctg aattgcaagg agattctaag aaggtctgtg
     2881 agttaagtat cgaggagtta aaacattatg gattaactca gagagatgct attgcctttc
     2941 tttcaatgct tgaacttttt aaacgttcag aaggtgagga agaaaagcca acttgtgtca
     3001 ctgggactgg atattttgct caaagtatcc aaaaagccta tggacataag aaacaagagc
     3061 atcttgtagt gtggtacttg gatgtgcatt gtaacgttat cgaggagcga gtagttttca
     3121 tcggtagcgt tcatcgtagt atggcgtgtc caagagagat ttttcactat gcagtgaaga
     3181 atttagctcg ctacgtgctg gtagctcaca accatccctc tggaagtgta tatccttcaa
     3241 gtaacgatat taatgttact gaggcccttg aggatgctgc aaagctcttt gaaatggagg
     3301 tcttagacca tgttatcgta acgaaggata attactattc tttcagagat aacggaagaa
     3361 tgcgttgttt ctaggagagg agaaaactat ggggaatatt tctcatgcct ttggcaaggt
     3421 aactatttcc gcaccaacat taacggatat agaggtgctt gtggctactc atagagtaat
     3481 caatgaaaaa gcttggaacc ctacgactat agaaggttct ccaagtgaag cggattgtat
     3541 cacaactgaa gaaggatttg tctcagtgac acttcctttt acagcttgtg ggaactggaa
     3601 tattcgagag aatatcgata gctttttgac tgacatctta aagcaagata gcactcttag
     3661 cgatatccca atatctgcta catttgatta tgtagatgca gagtctggcg tgaactttat
     3721 ttataaagca accgttatga ctcgcaatgt cccaggtaaa ggggtaacca ctgaactctt
     3781 aactgatgaa gaccttggag attattccga gtcttatctg aaagagttag agggagtcta
     3841 tgaacaagag ctagctctag caagtatcac agtctgaaga aaggtgttat aataagatga
     3901 agaaaacact agagaggatg atggccatga aagagacatt cttttgggac ttcagtcaag
     3961 aggatatctc gacactttct gatttgacat ccgagggttt tgaatttgac tggtcggcta
     4021 ttagttctcc caatgcaatt accagtggtt ttgtaattca aggtgaggtt tctggtatga
     4081 ttgaattcac tcctgagcct actgactatt acaattttat ccataagctg gaggtgcgaa
     4141 tggataaaag gaaccaaggg attgcaggtg tcttgcttgc tcatgtagca caagacgctt
     4201 tcaatcgtgg ctttgagggg tttatgatgc tgatttcaaa gacagctctt cgagactttt
     4261 atgttagtcg gtacggaggc agtcgtattg gaaacactaa ccgagtgatt tttaatacag
     4321 cagcatctca gggactcatt gaccgttttt tgaagggagg agtagactaa ccatgagaat
     4381 agttgaacga ttcaaagagg attggaggtc gttaggctta ccagataaac catacaagac
     4441 accagaggag attgaaatga tcaagaatgg taatcttgtc tgggctgcgc gtgttgagca
     4501 aaatttgggg cgtaagttaa ccccaagtga actcgatgag atgcagtggt gagccacaaa
     4561 acaaattaca tagtacgtta tacatcgtat atcgtacata gaagaggaag aggaaggtag
     4621 tagccctagg ctacaccttc ctctttttct atggaggaga aaaacaatga caacacttgt
     4681 accaacaaca cttttactag gaaaaaaact gttagaggtc aatggttcat tctcaggaat
     4741 gaccttgcat cagtttttga acgaaactgg gaatagccat ctttttatca agaaggatgg
     4801 aatggttgct atcaatacct tgttagaaca aagtaggtta atgcctattt cttgtgatga
     4861 ggcgttggtg gcaatggaag acttaaagat gactagttta aggtcacaat ttgggttctt
     4921 cattaaacca acccaatata aacgccaaaa tccagaagtt ttggtgcgtt tgggaaacaa
     4981 tcgtaaggtt gtattccatc gctattactt tggtaatggc tatatggcta acctggtcta
     5041 tcaggtagaa gatgatcaga ttgagttctg ccagtcttct gtctttaaga gctgggataa
     5101 tggtgagtat catattactt acgatacgcc agtaacagaa gatgttgaag acatcaacac
     5161 acgcaaggag ttgctttctt tcttaagtcg tgttgaggaa cttcctttta ttaagtaagg
     5221 aagttattga aattgagttt gtaaaataaa aaggagaaaa acaatgacta aaaaaatcta
     5281 tgtatacaaa aataaaaaag cacaagaggt ctttgcagat ctttttgcta aggaccttct
     5341 tgaaggcgtt acaactttcc ctcggattga taacgctcaa tcctattcat tcttggaact
     5401 ctcttgtttt tatctcaaga gaattctgga aatgaaggag cgtaaggttc aaaccctttt
     5461 cgttgaggga aaacccgaac cagcacttgc ttcagcattg ttacaagcac gtgctatggg
     5521 actgaatgtt gtcattaaat tgaagacaac tgagagtaat gttgagactc aagaagggct
     5581 caaagagctt ggtcttgacg atgttgtaat ggcttgaccg aataaaaaaa ggagaaaaca
     5641 atgacaatca ctcaaggtat ctattatatt gaaaaagttc accaatataa taggaatatt
     5701 gctggctatc cgtcagactt aattgatgac cggattgcgt cgattattga tagcaacaag
     5761 gcggaaatgc aacaaagttt gcgatgccga ccagttagga acgtggtttt gaatcgagag
     5821 ggagtatcta accttcctcc gattgagatt ccatttgaat cttcacttta ttatgaagtt
     5881 gaagaaatca atcctggcct atcgaagttg actatttcta cagagcatgc aaaagccttt
     5941 caagaggctg atatacgcat gttggaaact cgcttaacta tgttacagcg tgccaaagaa
     6001 tgtggaaatt ttacgacaag taattatccg agtcgttttc caaaggaagc aagagtcgat
     6061 ttaagtcagt tagatcttct agcttgggga acaaaagata tgcctacata tcttttctgt
     6121 ctgatggaat cagcattaga tagttaccga ggattttatt ccttgaggga cttgatggag
     6181 gatgctaacg gtacccttca gcaaggttat gataaagcag tttactggat ctatagtggt
     6241 gtcaaaggac aatatgaata ttagaaggag aaaaaatgac taaacatagt tatgttgcga
     6301 aatttaagcg taaagacgaa accgtcttta cgaaaaggtt tctagcttca gatttatttg
     6361 aggctgttga acatgcgcta gagtatggca ctaagcgaga tattctctat ctcgacttag
     6421 tgcctgcagg acagtagtca gtagaaatta aaaaggcact taaagttttt taactttgag
     6481 tgcctttttt tgttactttt tggtatcttt tacgaataga tatattgtag aaaataggag
     6541 gtatataaaa tgatgactta tgatgaagta atggaagcga tagaaagagg gtttatcaag
     6601 ggagataaaa tcagtattat tcgacgaaat ggcaagatac atgattatgt tttaccagga
     6661 gagaaagtag agcctggaga aatagtggaa aaagaggact tagatgttgt ccttgaagag
     6721 ttgaaggagt tctaaaatga tgcagctttt tagtaagatg attgcttagt taatagcact
     6781 ccttctacga gcttataaaa ttcattttat gatctcgtgg aagggcgcta gcttttaatt
     6841 ttcctcccaa aatgtgtcca aaatattgac agaatcccaa acctcaatta tttaaaatgg
     6901 aatgactggg tactataagg taggtgactc aataggaagg ataatttctg tttgaaaata
     6961 ttctccttgt tcacttgtga taatcatact acctccatgt aaatcaacaa tttggttaga
     7021 aatttttagt cccataccac ttctgcgaac cccagaaata tcaaaattaa attcctcaat
     7081 tttattaata tttttaagtc tatctgtaga agttccaatt ccattatcac gtataataac
     7141 tgaaaattta ttacgggaaa tatagttaag gacaatctga atattacaac cagaagggtt
     7201 atgcaataca gaattataaa tgagattgtg aataactcta gacatcaaag atttttcaat
     7261 gtacattttt ttacccaaca atttattatc aggaataaac tcaaaattaa aatcattcca
     7321 aatctcttga ttaataattt gtatgattat ttccttaaag aagggtataa tgtctgttat
     7381 ttcttgattt aattttaaat tactgtttgt tagtctagcg aatatgttga gatcgtttag
     7441 caaattttga atatagtgac tctcaaccag cgtaggtttc aaatttttta ataggccatc
     7501 attgtctgtt ttttcaatag ctaatgatgt attagccacg ataactgaga gaggggtttt
     7561 gatgtcatga gctattccag aaatccaatt ctctttgaat tcttcatttt tacgtagttt
     7621 tttgttagca gagttaaccg ctaaagttaa tctatttaat tcttgaacag agtttacctg
     7681 tttgtttaaa ccgacaggta atttacctat tgcgttaata attggctgga tgttgcgatt
     7741 taagaaagta acactataaa ggtataggaa taggcaaaat aggcagttaa caaatatgat
     7801 aactaaaatt aaaatcggaa aaatttgaac tctttttaga tcaaagaaat tatttccgta
     7861 tctaatgata ctttcttttg gaaatgcaat tatataaata tctttttgtt ctttttttat
     7921 ttgagtgaat attggatagt catctaaata ataacgtgaa aactttatga catcggcata
     7981 atcaaattgt gtttttatat ttttaggttt tttgatatta aacttttcat ttccactttc
     8041 ttgatcaaga atcatgaccc ataagttgtg ctttttaatc agtttttctg cagtttgatt
     8101 aactttatat gttccatttg atggggtgat gttcgaagat acaccttgta tgatatctat
     8161 aggagattgt tggctacgga taaagttggt tgtagctact aatagaacaa aatcgataaa
     8221 tattatggta agaaaggcga gaataaattt taatatacct tttttgaaaa cattcataga
     8281 ggactccgta aattcagata actaacttat aacccagccc tttgactgta atgagatgat
     8341 gtggttttga tggggataat tctatcttct ctcttatatt acgaatatgt accattaagg
     8401 atttttcata tccgaaacta tctattcccc aaatagtatc gcagattgct tctgttgaca
     8461 caatatagtt tttattggta tatagttttc ttagaatctg tatttcagtt ggagttagtg
     8521 ataaatgctg ttcctctttt tttacactag cattatttaa atcaatgata caagaagtta
     8581 aagttattaa ttctgattct cctttatatg ctctcctcag taaagcaatt atacgataga
     8641 ttaaagtttt aggaagaaat ggttttgtga caaagtcatc accacctgaa tctaatcctt
     8701 taacttcatc atctggatta tttttggctg ttaaaaacaa aattggtata tcagaagttt
     8761 ttctgatgta ctgagcaagt agataacctt ctccatccgg caacattacg tctaggataa
     8821 tgagatctat tttagaaata gaaaaaatat ctattccttc gctaatactg taagcattac
     8881 taatattttt aaatcccctg ctcaccaaaa cttctttaat agatttacta agtgaaacat
     8941 catcgtctac tattaatatc cgtttgttta atagctgcgc ttcgaaattc atatacgcgc
     9001 ctcccataaa atttatttta attataccat aaaccatctt actttaataa actgtaggca
     9061 gataggaaat ttaaattctt aaaaataatt ttaagatttc tttactctgt cttaacctag
     9121 tcttcgtaaa atttacttgt aacaaagata cttagtctca aaataataac ggattatcaa
     9181 tagctttgaa tagtcatgtg ctagaggtaa cttagtagat tattcttaaa tcttagaaag
     9241 aggaaaaata tgaaaaaaga tgtagttatc gaatcaatta aagaagtaag tcttgaagag
     9301 cttgatcaaa ttattggagc tgggaacggt gtgtttaaaa ctatctcaca tgagtgtcat
     9361 cttaatacct gggcatttct tgctacatgt tgctcataat aattattaat ttagagagag
     9421 gaaaaatatg aaaaaagatg caattatcga atcaattaaa gaagtaagtc ttgaagaact
     9481 tgaccaaatt attggagctg ggaacggtgt gtttaaaacc atttcacatg agtgtcactt
     9541 gaatacttgg gcatttcttg ctacatgttg ctcataattt ttgatgacta agtatctaca
     9601 ttgttatata aagaagaggg aaacctcttt ttttatatga tgaattttgt ttatttattc
     9661 attcatgtag ttcatataat ttatgactat atattaaatt agaaatttat cttgacttta
     9721 ctttgcctta aacttgtctt tatgttgcaa ttttagaatc aatttataaa gaaaaataat
     9781 ttcgagccag actcgacatg aaatttaatg aggttataga ctatgaaaaa taataaaatt
     9841 catctagaag ctttggaagc gttacaagaa ctaaaaatgg aagaaataga taatcttttg
     9901 ggcggagctg gtcatggagt aaatactatt tctgctgaat gtcgttggaa tagcttacaa
     9961 gctatcttta cctgttgtta atttttagaa aggtaagaca atgaatcatc aagaacaatt
    10021 atatagtcag tttaataaat ttcctaaagt ttttattgaa aagaaaatac ctgaagttct
    10081 taatgaggat gttaaggtac taaaacaggt tgagaaaaat atatcagact attatcgatc
    10141 tacattaatt tatttgatta acgaaaaacg tattgaaggg aagttaattg gcgacacagc
    10201 tgagctacga tatgattatt ttaataatgt attatgtaaa aatggtgata ttttagaaga
    10261 aatagaggaa agatttccga ctattagtca acgtgtcatc atcagtatag agcagtacct
    10321 tgatttgctt aaatgcgtaa aaaaacattt ttcaatagac ttttcaatat tgaaaaaaat
    10381 aaaatttatt tgctcagatg atgaaaatcc taatttaaac aatcttgata ttaaagtaac
    10441 aggtgatatt cataatggaa gtggtgtttg tattttatct tatgatggac aaaaattagt
    10501 ttataagaaa aaatcgtcaa aaccaaatca tcttttaaaa aaattggata atcaagttag
    10561 caagtattta aaaaaagaga ttcagtttgt acctgacttt ttagataggg aaggttactt
    10621 ttgggaaact tttatagaca gtaagccagt ttgttcgatt gatgaagcga aagagtttta
    10681 taaaagaatg ggttatcttg tagcatatgc ttacatttta aatatttctg acttgcattt
    10741 cgaaaatctt atttcacata atgttcagcc tatcctagtc gatgctgaga cagtattttc
    10801 tgtaagtccg tatgaaacag tagcggataa taatgctact ttagagataa ttcgggatag
    10861 cagaaattca gtactatcta caggattgtt acctgtgtct gaagccgata aaatttttgg
    10921 aggagatact agtggagttt tagggggtac tcttattggt gaagcaagag tgctgataaa
    10981 ccagaataga gatgatatac atgttgaaaa acaaaaatat aaaacagaaa atcaagctca
    11041 cttaccttat cgagtaggac aaacgggatt aaggaattat ttaaatgctg aagattacat
    11101 tgattccatt aaaatgggct acctagagtt aagtcatttt attattgata ataaagaatt
    11161 tctaaaacaa ctttatttaa gttttagtga tttaaaaaca agagttttat ttagaaatac
    11221 tagagattac agtttagtcc gtcaattgtt gacttcacca atttattgta atcagtcaaa
    11281 tgttttattt gaaaagatgt ctgataaatt atcaaatttt gaaagtttga atttatgtga
    11341 atctgaagaa aaacaattac ttaatatgaa tattccatat ttttattctc gtattagtga
    11401 tgtcgacatt aaagataatg agactatagt atggaaatta aaagattctg ctttaaccga
    11461 ggcattaaaa aaattggaaa gatttgactt gagcataatg agggaacaag tcgatttaat
    11521 tgaattttct attaaaacac caaatgcttt gtatagtacc gagcttcaag aatcgtacaa
    11581 aaaatttaat aatttaaatt cagataaaga ggttttgttt gctggtatca atacgctagt
    11641 tgataccatt ttgaataatg agaaatgctc taaattagat ggaagtacaa attggttaac
    11701 gcttaaagtt acagattatg atgcatttga acttgaacct atggatctat ctatttatga
    11761 gggaatttct ggattatcaa ttgcattatg tgaagtctac gatttagtga atagtgaaag
    11821 acaggagaaa atttataatt gtatacatag aatttttcta actctctcaa actcttacga
    11881 tagtgtgcaa aatcaatcgt actacgttgg aaaattaggt attctttctg cattgaaaag
    11941 aatacagttg attacgggac aaaaaatctc aaagtctatt ttagatagaa ataaggatta
    12001 cagtttagat ttgaatgttt cgagtgcaga ttttctttca agttttccta atgagattgt
    12061 tgctctgtat agaagtgatt tgtcaattaa aaatcttcga caagccttag ataaattaat
    12121 tgatttaaag attaattatg agaattatat tgcttgggat aatttggaat caaataatgt
    12181 tagtttagca catggaaatc taggaataga attggcatta cactatattg ctggaatttt
    12241 ggataattct aaagccctag agatgttatt tcaagcgaat aactttgata atcgccaaaa
    12301 aatatctcaa ggttggatag ataaaagaaa taattcaacc agtgctaatt ggtgtcatgg
    12361 ttcaacagga gttcttgttg caagattagc tcaactagaa ttggataaaa aatttcagct
    12421 aattcctagt gctagaagaa aagagttaga agctgatatt agacatgcag tatctcaaat
    12481 aattgaagtt ggattcaata tgacaaattt ttctatttgt catggaacta gtggaaattt
    12541 gttagcactt aactattatc gttcatatct taaaggacac gaagcacaag agttggaaaa
    12601 aattttggaa attgagtata ggaagttgca ttcatttggt ttagaaaatg ggtggatgtg
    12661 cagttttaat actaaatata atgtttatgg gattatgaat ggtttgtcag ggatattata
    12721 ttctacagcc aagtatataa aaagagataa ttctctagac cttctaatcc ctactctata
    12781 atcagcgata ggaaggaaac tttatacatg aagattgttt tgcaaaataa cgaggaggat
    12841 tgcttattag catgttatac aatgctatta aatgatctgg ggcacaaagt ccctttatat
    12901 gaggtatata ataaagatac cttaccagcg gatggtctga atgtatcgta cttactatct
    12961 cttaacgaga ggtttggagt aaccttgaat gcataccatg ctacatatga ggatatatgt
    13021 aaaatctata aggaacagaa acgaaggatg attctccact ggaataatga tcattttgtt
    13081 gttttagaaa agattactgc aacccaagtt atgatagtag atccagcaat tggtcgagta
    13141 aaatatagtt atgaagaatt tataaaacac tactctaaaa caatagtgtt gataagtaaa
    13201 agtaagaatt ttcaaaaaca aaaatataac caaatttttt ggaaatattt tatacaaact
    13261 ttgaaaacaa aaacaattat tttattttta gtttcattag tgttaatcca gatcagcgtt
    13321 ttaatatttt cggtagtatt aagatacatg ttagcggaaa aatttaaatt ctgggccagt
    13381 atcattcttc tagcgggggt agttttattc caactatttg gatattttat taaaaataat
    13441 gcactggatg aatataattt agattttgat aataattata gcagaatact ttttgaaaaa
    13501 ttattgaaaa agccactttt atattttaga aatcatttaa gcggtggaat ttcagaaaag
    13561 attaatttca aatctacctt aagggataat gttactttaa aaattattcc gtcatgtgtt
    13621 agttttattt cagcaattgt tatttttata tatctgatga ctatttcagt caaattaaca
    13681 gtgattctag ttacgatgat ttcagcgtat agtattattt caatatttct ttatcgcaaa
    13741 caaaacgaat ataatcaaac ctatttgcag tatctaattg attttaattc ggaattgcaa
    13801 atggatttag acgatattga ctatatcaaa attatgaggc gggaaggttt gacctttagt
    13861 tcatggatgg atattaataa aaaagttact gaaaagtatt cacagatttt gaaatttgaa
    13921 aatcttacac agctgattgg tacgattttt aattatatta gtctctcggt aatcatcata
    13981 gtagcagttt actatgaaaa ttatatacat gtttccattt cagacctatt agtttatcag
    14041 actagtattt cgttattagt atcagctatt gagcaagtta agggggctgc ttttgaagct
    14101 ataaggttag gtgtctatgc agaaaaacaa agtgatttat taaaagacag taaaccaatt
    14161 ttagtacaaa gctcgagttc agacgagtat ttgataaaag ccgaaaagtt gaatttttct
    14221 tatggcatga agccgattta taatgacatt gatttaacaa ttggtaaagg agaaaaagtt
    14281 gctatcgtag ggaaatcagg tagtgggaaa tcaacgttat tactgttatt agcaggtatg
    14341 ttacgttata atggctcatt aaaatatggt atcgaaaatt ttgaagaatg tttgagtgtt
    14401 gttcttcaga atatgacctt aagaaaggga agtgtattag aaaatttgga gtgggattca
    14461 gatgatttaa cacccctatt tcaagtatta aaagatacct cggcagatga agttattaac
    14521 caattgccaa ataaagttca ttcaaaatta ttaaaacaag ggaaaaattt atcgggggga
    14581 caaattcaga aactattaat agctaaatcg ttacttaaaa atgaaggtat cattttttgg
    14641 gatgaagcat tcagtaacct cgatgaacaa agtaaaaata aaatttacac caatattcta
    14701 aaaaatagta attattcaaa aaagactatg ctgatggtta gtcatcatct agatattgtt
    14761 gaatatgttg attacattat ctatatagac gatgagacag gtaaagtcta taaagatact
    14821 catagtaatc taataaaaac caatgaaagt tacttcaact ttattaattc aaaagtatag
    14881 taaatatcct gttctatctt aatgttatct ttaagatgat aaagtagaat tacattgtaa
    14941 agaaaggagt aatcctggct aaaaggatta caaggtaatt aatgagatga ataatattat
    15001 tgaattgaaa aatcttaaaa aggtctataa agatactact acagtggatc ttaagaaact
    15061 gacagtcaga gaaggggaaa tctatggttt cttaggaccc aacggtgcag ggaaaacaac
    15121 tacgatgaaa atgatcttat ctttagtgga gcctacttta ggagagattt tagtcaatgg
    15181 tcaaaatatc aaagaggata atgattactt aaatcaaatt ggatcaatga ttgaggaacc
    15241 atcttattat ccaaatttaa cgggatatga aaacttatta gtatttcaaa aaatggtagg
    15301 ttttgatgag gataatattt ggccaacttt gaaattagtt ggattggcgg aggacaaaaa
    15361 tcgtaagaaa ttagtgaaag cctattccct agggatgaag caacgtttag ccttagcttt
    15421 tgctttagtt aaaaagcccc aaatcttatt attagatgaa ccgactaatg gtcttgatcc
    15481 agcagggatt catgaaattc gtgagttgat tgttaaatta gcaaaagaag aaggcttaac
    15541 agtctttatc tccagtcaca ttttatcaga gatagaacaa attgctgatc gggttggtat
    15601 tataaatcat ggttgtttag tttatgaagg agagattcga gagatcaaat caaatacttg
    15661 gattgggatt ggtggcgatt tttcgcaaaa taatattgtt caacacttag ttgatttctg
    15721 ttcagtcaaa gtacgggaag catcggcgag tgaggttaaa ttagacgata tgagtaacga
    15781 tcgtcttgcg gatattatca cctatataac agaccttggg tttagaattt ttcgtgtcac
    15841 tagagaaagt gagacattag aagatatttt tctggaacta acaaaggagg tataagatga
    15901 aaggtgtgta cattgaatgg ttaaaaagta gacgaacaaa atctttttca attgttactc
    15961 ttttgatgat tgtagcgaca ttgtggagta ttgcaatgtt tatgtctgct ttttcgcatc
    16021 cagagttaaa aaatgtcgga actttattta gtaatcagaa tgtcaacctt ctcatgcttc
    16081 ctattgctgt ttctgtattt gtgagtcgaa ttgtgagtaa tgaacgtgaa ggacagacct
    16141 ttaaattaca agctacaaat ggcttaggtt tgatgactat ttttagacat aaatttttat
    16201 ttacaatggt cttcttcttt gtcatgtctt ttgcagaaat tgtagctatc tgttgctttg
    16261 gaaaacaatc tggtatctca attcctatgg acattgtagg agttcaattt ttaggacaat
    16321 tactatctat tttcgctcta gtttctatct atttaacgtt agcaatggtt ctagaaaaac
    16381 aaggcgtatt actggcttta ggattgttag gaggtttttt aggaatcgtc ttaaatccaa
    16441 gaagttatgg ttttgctagt ttgcttaatc cgttgaccgg agcaggcagt ttagcacctt
    16501 ataagtatca ctttcttggg gatggggcat atacctacct cttggatcaa cagttacctt
    16561 ggaaactagt attctttatg atttattgtt tgatgttata cggtttagct aatgttattt
    16621 tgagaaagag aggaagttga aatgagacct tatgtttttg ctgagtggaa aaagactcgc
    16681 aaattacaat tgttcatgat tggaatggca tttttggttt tttctagctt tatcggttta
    16741 ggagcttatt ttgctaatag ggctgtctta attgataaga cacaatccct tgttttatgg
    16801 ggacaattaa cattttataa cagtacactt ctctatcctc ctatgttagc cattattgtg
    16861 ggacagttac tgatgccaga atttgagaga aaaaacattg agatgttaaa agctaatcaa
    16921 gtttcaatgg ataaattgta ctttggaaaa ctattaagtg gcttctttct gattctttcc
    16981 gtccaacttt ttttaatact tatttttgtt gtagctgcca aagttgacgg gatttcgttt
    17041 gacctcagtc tagcagttca tattaaatgg cttctgttat cagtggtggc ctcttttccg
    17101 ataatgacgc ttcaatcctt cgtaaccgca aagactcgta attttagtaa agctgttgga
    17161 gttgctacaa ttggtagcat gttaaacttt gtgctgattt ttattaacga gaatcttaca
    17221 aagtttttcc cttattctca accaatgatt gccctacgca gtcgttcttt aacagatatg
    17281 tccttaatag atttgacgat ttttctagtt gttaatagtc tatatagttt acttttctat
    17341 aaattaacag tggcagcttt gaagaaaaac gaataatgtt ttaaaaatat atccattgtt
    17401 tatgtcagaa taaggaaatt tcaatcaaaa ttattgacag taactattgg attgcaaaat
    17461 agctacaaag aatgaaattt atttatttat catatgagag tttacttttt ataaagcgat
    17521 attttatttt acattttaaa aatattaata aaaaagaaat ataaaaaaac aatttttgca
    17581 ctttttactc attaaaaata aaaatgtatt gtttacaata aaagtgtaga aattatttac
    17641 tacatactaa cagaaaggag aatgattgcc atgaaaaact caaaagatgt tttgaacaat
    17701 gctatcgaag aggtttctga aaaagaactt atggaagtag ctggtggtaa aaaaggtcca
    17761 ggttggattg caactattac tgatgactgt ccaaactcaa tattcgtttg ttgttaatta
    17821 aaacaatctt gataagtaga ctaaaaattt cctgtttaga cttagtttag gcaggatttt
    17881 tgagtaatgg taggataaat atgataaaaa gagatgaatt aaagttagaa tatcaacaac
    17941 atcaatttta cgaatacttt aactcaattt ttaattacga catactagat acttctatta
    18001 gtgaaaatat ttatttgtta agggaaacga cacataagtt attttatagt gagtttgaaa
    18061 atcagttatt tgaaaccata atgttccttt caatgaaaac gctagtttta gatataaata
    18121 atttttccaa agaaattgaa aataagtcag aggcatatga acaatatata cagcagatag
    18181 gggaaaaaga cggaataagt aatttttttg acagatatcc gtatttgcta aaacaaatca
    18241 atagagaggt cggattgata gaagaatcat attctttact atttgataga tttttaaaag
    18301 atttgtctga aataaggttg tgctttaata ttactgagcc attaagtaat gttgagtttt
    18361 cacttggaga tagtcattcc aaaaaacaaa cagttgttaa aattgaattt aaagagaaat
    18421 ctgtttacta taagcctaaa agttatgatt catacaatat cttgttagaa cttattggtt
    18481 tattgaaatc taataatata ccctcgttca gtcttcccga aagtttagtt aaagtaggtt
    18541 attgttggca acttggtgta gattatacac gttctaacaa tgatgaggtg aagaaaattt
    18601 attttaagta cggtgttttg gcagcatttt ctgaaatttt ttccattacg gacttacata
    18661 tggaaaatgt gattgtttca ggcggaaatt tatatttaat tgatgttgaa acattttttc
    18721 aaagaaagtt gaatgtacaa aataataatt ttgaagggat tactgttgat acctatcaga
    18781 gaatttatga gacatcactc tcaaatggtt tgtttcctgt acaatttgag aaaaacagcg
    18841 ctcctaacat ttctggaata agtggaaaag gcggaaaaag aaaaaaagga aagtatgaac
    18901 tgataaataa aaatcgtggg gatatgaagt tagtgagaac tgactacttt caggaagatg
    18961 gctacaatat tccaatatta aatgggaaag tggtggaacc tctcgactat gctaatgaga
    19021 taattacagg ttttagagag tgctatatat ttcttctatc gcaacgtgca aagactaaag
    19081 aaattttaga agatttcccg aaattgaaaa ctagagccat attcagaaat acttccgact
    19141 atggaaaatt cttacaagcc tctacgaatc caaaatatct tttctcagaa aaaaagaggg
    19201 agaatttatt ctcgatacta tatgagtcaa aacatattga acaatttatt gttgctaatg
    19261 aaattaaaga tttgatgaat ggtgatattc cttacttttc aatggatacc agtggaaatg
    19321 tatataattc tttagggaca ttaattggaa atctaggaga cacaacctcg ttatttgata
    19381 atatagctac cctgaacgat gaaagaatgg agttcacttg tgaattgatt gaaattgtct
    19441 tgaaaaaacc gattaagcat tgggagagaa aagagggaaa atcttatcat ttcccatcaa
    19501 tatcctcaga acaaagtttt agtgaggaaa tcttagatag cgttagacag atatttattg
    19561 aggcaaataa gaattgtttt tcttctttgt agaaataata ctaggaaaaa gaggtagtcc
    19621 attgagactg gcctcttttt ctaccatttg tcaagtataa tacggtttct gactcaacat
    19681 tatttctgat agagtataaa aggaattttt gagaaatagt tcaagccatt ttttctgaca
    19741 tttgagcata taaaaacgac accttatctg gcattttttg aaataaggtg ttagaattac
    19801 agggcataga cgactttaat gactttgggc taaagtatag tcgtaaagtt tattatgcat
    19861 tataagataa tacattgtcc taataaggcg atgtatagag gcaatcgtat gaggcttagt
    19921 tgaagttgtc tgcgattgtc tttttcgttt ctcatagaaa tctgcgatat ggcaaggatt
    19981 ggtatgacta gctgaagcga tgttgtgaat gcacttgaac aagatttttc tggcataggg
    20041 attacctcgt ttagtgatgt gttccttggc gagaaagttc ccagattcat agtgtctcag
    20101 gtcaatgcca ataaaagcgt tgatttgatt ggtagactga aagcgacgaa tatctcccaa
    20161 ttcgccaatg atagatgtcg ctgtggtctc tgcgatgcca ggaatagaga gaagaatctc
    20221 atattcaggt agaggtttag ctaactctat caactgttct aaaacttgtt cccgacggtt
    20281 tgtcaacctt ataagttcct gtgcattata cttaacctct tctatcatag gagaggtttt
    20341 tgaaatggca gaataagatt gctttgccag tccaactaac ttctcagcca agttacctgc
    20401 tctgttctct gaaatgcgtt tagaggttga ctggcgaata gtctctttca actcaacttc
    20461 cgataattcc agcacccaat gctttgttgg gaagatggac acgagattcc aatattgttc
    20521 acctgcagga gtagatagta gaatctcgat ttctgggaag gcgacttgaa gaaccttgtg
    20581 cagcctattc ttcgtcctta cgatatcctc tgtcagattt tggtagaacc ggctaagatc
    20641 atgcaagttt tgatagactt tttcttgaac ataagttggc atacggttta aaacgaattg
    20701 tgacgaagct agtttctctg catcaatctt atcggttttt cgaactcgta atccatcaag
    20761 ttgcttctta gcttccaaag gattaagacg tgtatagtca tagctgtttt cttctagaaa
    20821 agcttggagt cggcgagagt agacaccagt agcttcgaaa ataatttcag ggttgctcac
    20881 ggtctttaga tccttcagta gatgagaaaa tccgataatg tcattaggca tagtatatcc
    20941 atgaaccctt tcaccattca caagaatagc gacttctgag cttgctttac tcacatcaat
    21001 tccaaaaact gtccgcatta tgtttacctc tttgtcttga atgattcctt attttagtga
    21061 tttcattttc aatactcgac gtctagcgtc caacatactt tgataaaatt ccatctaaaa
    21121 caggtgtctt gccagttttt tgtacgacgt ctagcgccaa aagaagccac gacttaacaa
    21181 gacacctcta ctttaacaca aagaaaaagt agtgagtact ctctcccgtc ggagatttct
    21241 tcactactaa tcttagtatg ttttttgttg tcttgtaaag gttactttga aaaaaaccat
    21301 tggaacaaca ggaagttcca atggccacaa caacaatatt cttcataaaa accataacgt
    21361 ttttagaaaa aaagttatgg aggagaagga gaaagacaac ccctccatat agttcccccg
    21421 aagggaaaaa caatgacttg tatccaggaa aaatcctaaa tacacttcta gtatagctta
    21481 ttgatagtgt tatttcaagg gtaggaaatc aaaataagag tgttattatc tcaaaagtca
    21541 acctatgtca ctaggttgcg acacctatat aaaatagcct atcatggctt catggtagaa
    21601 tttaaagatt atgaaaatac acaggaacta gaaggctggt acaattggcc agttagggcc
    21661 tctaaaaaga taaaatccat tagggcaatc aatagcgtca tctcttactt taggagacat
    21721 cgattaaagc gaacgctaat cattagctat actttactgg gtacaatggt atggacagct
    21781 acgactggct atttctctcc taaacgggtt acttacacag acacacagct acgagcgacg
    21841 caaacctttg gtaatggcct tgggagcatc acagcaacct ctatgacgta ttcaccatct
    21901 aatggaatgg tcgttatgga attagcaaca tcagatgcga ctagtgctat tcagaaagga
    21961 atcaatactg aaaatcttga ttggcaagtt ttcttgccaa gtagtgttaa gaactcagaa
    22021 gcagtgactt tagaagtcat tccgttaact ggagataaag tgtatctggt cttgcgtaat
    22081 gttccttcag attatacgct catggttatt cgagtgacca ataagacgcc aaactctaac
    22141 agtctaaagt tggatgttca agaatatgac gattacttgt cttcaagtag taattcagtt
    22201 tccaatcaga aaaaacaaaa agatacggat gctaacaaga cctatgttga tttctttgta
    22261 actcctcaaa atgaacttct caaaaacaag tatgttaaga atttatcacg tgagaagttt
    22321 gctcttaata ttttcgaaga ggagttgaag taccaaaaag gtcaacggaa agaacttctg
    22381 aattctgcaa aaacacttga tgacagtatt aaggaagata ctaagacatt ggagcagttg
    22441 aaacgtgagt cagaatactt ggttggtaat gagttaaccg ataagcagag tgatatggaa
    22501 gctatcgaga aaagtatgga ctctaaagag aaagacggag cgaaagcgcg tgaaaatgct
    22561 gcttatgttc agacaatcat tgaacagatt gaaaagaata tcaaagcagt taagaatggt
    22621 acctacaagt ttaattcacc agtacgatca gtaaaacaag atattgggga ataaatataa
    22681 aaaggaaaga aaggacttta ttaacgatta tgacaattga cgaacaacgc tatttactta
    22741 accaggattg cctattgatg aaatatcagc gaggtaacgc t
//
