LOCUS       NZ_CP116257            21128 bp    DNA     linear   CON 15-DEC-2024
DEFINITION  Streptomyces lienomycini strain DSM 41475 chromosome, complete
            genome.
ACCESSION   NZ_CP116257
VERSION     NZ_CP116257.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces lienomycini
  ORGANISM  Streptomyces lienomycini
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7863969)
  AUTHORS   Ding,W.
  TITLE     Streptomyces riduolalong sp. nov., isolated from the soil of Tibet
            exhibits against Gram-positive bacteria activity
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7863969)
  AUTHORS   Ding,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2023) School of life sciences and biotechnology,
            Shanghai Jiaotong University, 800 Dongchuan, Shanghai, Shanghai
            200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. August-2022
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027947595.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 16:03:07
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,183
            CDSs (total)                      :: 7,093
            Genes (coding)                    :: 6,850
            CDSs (with protein)               :: 6,850
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 243
            CDSs (without protein)            :: 243
            Pseudo Genes (ambiguous residues) :: 0 of 243
            Pseudo Genes (frameshifted)       :: 141 of 243
            Pseudo Genes (incomplete)         :: 121 of 243
            Pseudo Genes (internal stop)      :: 14 of 243
            Pseudo Genes (multiple problems)  :: 26 of 243
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:34:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4449561
            Orig. end                         :: 4470689
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116257.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="22"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11128)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            1000..1128
                     /locus_tag="BJ961_RS20115"
     CDS             1000..1128
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BJ961_RS20115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_271414173.1"
                     /transl_table=11
                     /translation="MGSGWTQPAPRDLDDRLVRRLIAEQFPRWAGLPARAVLAEPG"
     gene            complement(1125..2588)
                     /locus_tag="BJ961_RS20120"
     CDS             complement(1125..2588)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894182.1"
                     /locus_tag="BJ961_RS20120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase family protein"
                     /protein_id="WP_381160805.1"
                     /transl_table=11
                     /translation="MSTPEAATHDARVMHRRSRPAVVAAALAAVFLGTLGNVSAAPARA
                     AERPVTADCPPALAGKATCYTGQDANGAHYTMAVPHRWNGSLVVHAHGGPDLGDTSDPA
                     RSTEDLERWAVMVDQGYAWAGSSYRRGGYGARMAAADTENVRRVFTDRFGRPDRTYLHG
                     QSWGGNVAAKAAETYGRRPGAYDGVLLTNGVLGGGSRGYDYRVDLRVVYQYYCHNHPRP
                     SEPQYPLWQGLRAGSTMTTAGLRARLQECTGYASEAADRTAPQQRNLDDILAVTGIPER
                     TLESHLRFATFTFRDIVTDRLGGRNPWSNRGVRYTGSHDDKALNAGVARFSADPTARRD
                     LSWDSDLTGRVSLPVLTLHAIDDPTAFVEHEAAYRATLRGAGRDGNLVQTFTNEHEHSS
                     LSDSEYANSLSALDSWVRTGHRPSPRAIAASCSAFDATYGEGCFYDPGFQPSAYASRVR
                     PRPGGLAWPAMTAAQERAWSRIEGVGIAP"
     gene            complement(2768..3874)
                     /gene="paaE"
                     /locus_tag="BJ961_RS20125"
     CDS             complement(2768..3874)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="BJ961_RS20125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_271414174.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPVRTRRRPAFHRLRVAAVERLCADAAAVSFEIPRE
                     LAGEFAFAPGQSLTLRREVDGRDERRSYSICAPAGSAPRIGVRVVPGGLFSAWLVEDVR
                     PGDTVEVMAPTGLFTPDLTAPGHHVLIAAGSGITPMVSIAESVLAADDRSTVTLFYGNR
                     RTDTVMFADELADLKDLHPTRFHLAHVLSREPREAEVLSGRLDAGRLSALVDSLVDVPA
                     ADHWWLCGPQGMVADAQQVLTGLGVPAERVHRELFFADDEPVREVRHEDSGPQGPVSEV
                     TVTLDGRSTTSPLSRERSVLDGAQQTRPDLPFACKGGVCGTCRALVTDGSVDMRRNYAL
                     EAAEVDAGYVLTCQSYPVSEKVTVDYDS"
     gene            complement(3874..4389)
                     /gene="paaD"
                     /locus_tag="BJ961_RS20130"
     CDS             complement(3874..4389)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="BJ961_RS20130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_271414175.1"
                     /transl_table=11
                     /translation="MVTGGPALLDAHRARHVAEQVPDPELPMLTLADLGVLRDVEVGED
                     GTVVASLTPTYSGCPAMAEMRADVAARLRRAGYARVEIRTVLDPPWTSDWITGSGRLKL
                     AEHGIAPPGAAPRGPVSLVLSPTRPAVPCPRCGSADTEETSRFAATSCKALWRCRACRE
                     PFEYVKEI"
     gene            complement(4383..5210)
                     /gene="paaC"
                     /locus_tag="BJ961_RS20135"
     CDS             complement(4383..5210)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="BJ961_RS20135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_271414176.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVDTTVPEGVDAGE
                     LAAECVALADDALVSAQRLAEWVTRAPELEEEVALANIGLDLLGQARLLYSRAGQVDGT
                     GRGEDAYAYFRDADDFRNIRLAELPGGDFAFAVVRLLVLSSWRLAHFRRLETHPDPVLA
                     AVAAKGVKELTYHRQYAAEWCVRLGDGTEESHRRTRAALDEVAPYLGELHTAYDVRDEV
                     ADDLRQVTEAAGLTLPVHRPLPGSGRAGEHTEHLAPLLTELQGVARAHPEATW"
     misc_feature    5217..5231
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            complement(5220..5531)
                     /gene="paaB"
                     /locus_tag="BJ961_RS20140"
     CDS             complement(5220..5531)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388027.1"
                     /locus_tag="BJ961_RS20140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_271414177.1"
                     /transl_table=11
                     /translation="MSADKPQTYEKQGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALT
                     HARDLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            complement(5528..6514)
                     /gene="paaA"
                     /locus_tag="BJ961_RS20145"
     CDS             complement(5528..6514)
                     /GO_function="GO:0097266 - phenylacetyl-CoA 1,2-epoxidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031683.1"
                     /locus_tag="BJ961_RS20145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_164386001.1"
                     /transl_table=11
                     /translation="MTTTHAAEAPPPDAPDGLQEHFDATIARDQRVEPRDWMPDGYRKT
                     LIRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTERLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTDAQREMVQDAVDRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEESGHHDFGTPDWDELMR
                     VIKGDGPCNDRRMERRRTAHEEGAWVREAATAHAAKQAARAEKGAAA"
     misc_feature    6533..6546
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    6651..6666
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.71"
                     /tool="antismash"
     gene            6691..7140
                     /gene="paaI"
                     /locus_tag="BJ961_RS20150"
     CDS             6691..7140
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971672.1"
                     /locus_tag="BJ961_RS20150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /protein_id="WP_271414178.1"
                     /transl_table=11
                     /translation="MSQATEQTPAEVMFAADEASRGLGIELVEHGEGTAVARMTVTPAM
                     VNGHRIAHGGFLFLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAEERAR
                     FGRSGIYDVSVWRGDELIAEFRGRSRSARDDTARETPGTTTKESR"
     gene            7137..8483
                     /gene="paaK"
                     /locus_tag="BJ961_RS20155"
     CDS             7137..8483
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (101-352). E-value: 4.4e-20.
                     Score: 63.5. Matches aSDomain:
                     nrpspksdomains_BJ961_RS20155_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345129.1"
                     /locus_tag="BJ961_RS20155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_271414179.1"
                     /sec_met_domain="AMP-binding (E-value: 8.6e-25, bitscore:
                     85.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTGAAPAPRPGEPLPHDLLDDAERLTREQLRELQLDRLRA
                     TLRHAYDHVELYRKKFDAAGVTPEDCRSLADLSRFPFTTKADLRETYPFGMFAVPMADV
                     RRLHASSGTTGRATVVGYTDNDLSMWADVIARSIRAAGGRPGHKVHISYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGQTARQVQIIQDFRPEIIMVTPSYLLTLLDEFERQGIDPRGS
                     SLKVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGVAQECVETKDGLHIWEDH
                     FYPEVVDPLTDAVLPEGEEGEVVFTSLTKEALPVIRYRTRDLSRLLPGTARPAFRRMRK
                     VTGRCDDMIILRGVNVFPTQVEEIVLRTPGVAPHFQIRLTARGRMDHMTVRVEARTDAG
                     PEQREAAARAIGQGVKDGVGVTVEVEVVEPETLERSLGKIRRVWDMRST"
     aSDomain        7440..8192
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BJ961_RS20155_AMP-binding.1"
                     /evalue="4.40E-20"
                     /label="BJ961_RS20155_AMP-binding.1"
                     /locus_tag="BJ961_RS20155"
                     /protein_end="352"
                     /protein_start="101"
                     /score="63.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ADVRRLHASSGTTGRATVVGYTDNDLSMWADVIARSIRAAGGRPG
                     HKVHISYGYGLFTGGLGAHYGAERAGCTVIPASGGQTARQVQIIQDFRPEIIMVTPSYL
                     LTLLDEFERQGIDPRGSSLKVGIFGAEPWTEEMRREIEERMDIHAVDIYGLSEVIGPGV
                     AQECVETKDGLHIWEDHFYPEVVDPLTDAVLPEGEEGEVVFTSLTKEALPVIRYRTRDL
                     SRLLPGTARPAFRRMRKVTGRCDDMIILR"
     CDS_motif       8160..8222
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BJ961_RS20155_0001"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="BJ961_RS20155"
                     /protein_end="362"
                     /protein_start="341"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQVE"
     gene            8595..9893
                     /locus_tag="BJ961_RS20160"
     CDS             8595..9893
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="BJ961_RS20160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_271414180.1"
                     /sec_met_domain="FMO-like (E-value: 3.6e-82, bitscore:
                     275.2, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.7e-11, bitscore:
                     41.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAAAHALKERGISFVCLEKAPDVGGIWRQPGAG
                     EQGPGYQTLHLNTAKQLTGYADFPMPSSYPLYPRHSQFAAYLRSFAEWAGLLGHVELRT
                     EVVSVRRDADGMWTVVSRGADGAETSRRFEQVVVASGHHTDPALPDPLPAGADSFTGTI
                     LHSLDYRDGGDFAGRRVVVVGLGASAVDIAADLSRHAERTLLSVRRGLHVVPKQLFGMS
                     VDEIAEAPWWNEMSFAERRQWVEQALLVARGRLSDYGLPEPDHPVFSSATTLSDEILSR
                     IRHGAVTPKPAIASFDGDRVVFTDGSSEAADAVVYCTGFRMTFPFLPAGCPVSADGSVE
                     LYRRVVPADRPGLYFVGLVRPVGAITRLVEAQAEWVARIIDGAAPLPPAEEMREEIGTY
                     LTGIVQRYGRTEGASIQVDVGPYLAEFREALPV"
     gene            complement(10001..11128)
                     /locus_tag="BJ961_RS20165"
     CDS             complement(10001..11128)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971675.1"
                     /locus_tag="BJ961_RS20165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_271414181.1"
                     /sec_met_domain="indole_PTase (E-value: 1.1e-145, bitscore:
                     483.7, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAAPTGAGPRGTPTLGSFTSGQLRRLGAVAGLSGADAETYAQVL
                     TDTLGPEAERPLNLPPPHRTFLSDDHTPVEFSLSFRPDAAPSMRVLLEPGCGADSLALG
                     GRAGLRAVRDMARRWNFTTDALDDVRDLFLPDAPQGPLALWCALELTPGGVPRVKVYLN
                     PAANGEERSAATVREALHRLGHRRAYDSLPKGSGHPFLALDLGDWAEPRVKVYVRHENL
                     TAGQAGRLSRTDSGPGPAAVEGFFRTAAGLGPDTAGLGRRPGLTCHSFTDTTTARPSGF
                     TLHIPVRDYARHDGEVLARASRVLRHHGMDSDVLDRALAALTERRPEDGVGLIAYLALA
                     HQRGSAPRVTAYLSSEAYAVRPPVVEAVRRPLPVS"
     misc_feature    complement(11254..11267)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            complement(11336..12685)
                     /locus_tag="BJ961_RS20170"
     CDS             complement(11336..12685)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388030.1"
                     /locus_tag="BJ961_RS20170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_271414182.1"
                     /transl_table=11
                     /translation="MNAHDTAPVPPPGCPAHGSGARVPLHGPEFAADPQAYYEYLRHYG
                     AAAPVELAPGVEATLVTDYAAALQLLQDSGSFRKDARRWRAFNEGKVGPDSPVAPLLAY
                     RPNCMFADGADHIRLRQAVTDSMARVDTRRLSRSTEQISGYLISQFAARGSADLLGDYA
                     KQLPLFVFNELFGCPADIGDRVLFGISGMFDGVNAEKATAVLFQAVGELVALKRRKPGD
                     DVTSWLMRHEAGLDDEEMVHQLALLLGAGAEPLRNLLGNTLHRLLTHERYAREGGLIDE
                     AIDDTLWENPPMANYAPHYPAADTELAGQHLEAGDLVLVSFAAANTGPTLKASRQAGSN
                     RAHLAWSAGPHACPSKEPARHITVTAIEHLLNELPDVQLAVPEDSLTWRPGPFNRALAT
                     LPARFTPARSSRRAEPLSAGAPAERDKATGAARPTERNGMWSQFLNWLTR"
     misc_feature    complement(12678..12689)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            complement(12701..13294)
                     /locus_tag="BJ961_RS20175"
     CDS             complement(12701..13294)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971676.1"
                     /locus_tag="BJ961_RS20175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_271414183.1"
                     /transl_table=11
                     /translation="MGSAPSLGERDYVREGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAESVDDLKGVRSKTTTTVAMDFGRLTISDRVVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEHYGLDYAIAVNHFAGTPPRDEPALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRYLLDRTR"
     gene            complement(13269..13646)
                     /locus_tag="BJ961_RS20180"
     CDS             complement(13269..13646)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="BJ961_RS20180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_271414184.1"
                     /transl_table=11
                     /translation="MTGHDGWQPEAPELVRQYVITKGRGLPDEDDLSLVTLVTASAEDT
                     RRPARLSPEEQSLLDLCSAGYLSVAEIAGHSHFPLGVVRILLASLMEGGHLTTRPPVAR
                     ARLADREILEEVLNGLRAKFG"
     misc_feature    complement(13605..13607)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13643..14044)
                     /locus_tag="BJ961_RS20185"
     CDS             complement(13643..14044)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="BJ961_RS20185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_271414185.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFGKDDADRV
                     AAAMSGVQSLSRTLAFFCEDPSQTWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVGQLGKRLTTPPRENLGAHS"
     gene            complement(14041..15231)
                     /locus_tag="BJ961_RS20190"
     CDS             complement(14041..15231)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="BJ961_RS20190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_271414186.1"
                     /transl_table=11
                     /translation="MTEYTGNPLLWVALVALVAAAVLVSRQRRAARALRQQVQGLRDHY
                     TELENDYGKSVLAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLSRLQNKYGDSALLQD
                     LLEIDHTNSQFGRRAQSIAVLCDGWLGGRRDTASVYDVVRSAQGRVRHFRRVEILSQVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINIRTVPKGICVVVDDAGVGMSDEER
                     TRADKLLATERASGVAGLGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     ELLTAMPEKKAPAPAARGTARPVQDAGGPESASLASSSETGDGLPRRRRKRPMAIVPGS
                     ASTPRPAGRSDSEQAQVMGAFQRGTQSGRVTEQGPGDNTGRTSRTPGASSEGHEVS"
     gene            15572..16324
                     /locus_tag="BJ961_RS20195"
     CDS             15572..16324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104742.1"
                     /locus_tag="BJ961_RS20195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_271417110.1"
                     /transl_table=11
                     /translation="MAGVFAAGVGAGAINSVVGSGTLITFPVLLATGLSPVTATVSNAL
                     GLVPGSVSGAIGYRRELRGQRRRVLKLGVGCLLGALTGATLLLSLPADAFETIVPVLVG
                     LALVLVALQPRLAKLVQRRRERSGARPRRDGGPALFAGLTLASVYGGYFSAAQGIIYLS
                     VMGMLLDEPMQRLNAVKNVLSALVNTVAAVFFLFAADFDWTAVALIAAGSGLGGYVGAK
                     VGRRFSPVVLRTLVVTVGTVALVQLVLR"
     gene            16498..17895
                     /locus_tag="BJ961_RS20200"
     CDS             16498..17895
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158115.1"
                     /locus_tag="BJ961_RS20200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_271414187.1"
                     /sec_met_domain="p450 (E-value: 8.3e-77, bitscore: 257.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDSKGHALVTLVAPPPIPRAAGSLPFLGHATQLMRDNLGFIAAL
                     RTTYGPLVEITLQPGTRTLVVQDPGLIRTMLTDLGPSLDKGRFFEKMGQLLGDSVVTAA
                     GQVHVRKRRHLQPAFARERIARYVDTMRGETDAAVDGWVPGRGLDVREAMVGLSLDMLA
                     KTVFSGSLDDATFRRLRADLSVVMNGVGARVMLPDWVERLPLPANRRFLAARDAVRATV
                     DRAVTELQDSGHDTGDMLSLLLRTTDEETGRPLSGHEISSEILTLAVAGTETTASVLSW
                     VLYELARDPGIEARVLAELGEVLGDRPVAFDDLGRLPYLRRVVEETLRLHHTGWLVTRR
                     TVTETRLGPWTVPAGTELAYCQHALHRDPVLFPDPLRFDPDRWLDDSGPRPTQAFLPFG
                     AGKHKCIGDRFALTELLTATATIVRRVRLELAPGQTVRPVAAATVRPRTLLMTVRPRAD
                     AAAPAAG"
     gene            18061..18789
                     /locus_tag="BJ961_RS20205"
     CDS             18061..18789
                     /EC_number="3.4.21.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016328090.1"
                     /locus_tag="BJ961_RS20205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypsin-like serine protease"
                     /protein_id="WP_271414188.1"
                     /transl_table=11
                     /translation="MRTTRLVPTVLAALLAALLSALALAPTASAVEPRPGDGGPRPIIG
                     GGYAQNAPWAARLFSGGQQTCTSTIISPTWILTAKHCVSGGNLAFRIGSLDQGSGGTVA
                     NGVQTVTSPSADLALVRLDRSVSASYARLGQPGTVRVGQTVQVYGWGATSRCGSEINCQ
                     SQYLKVANVSVTQGCYDAYYGQAICARPVDGITAGGDSGGPMMSGGVQVGVASTSDRQS
                     TTAYTNVTAYRSWIQSVAGV"
     gene            18944..19783
                     /locus_tag="BJ961_RS20210"
     CDS             18944..19783
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388049.1"
                     /locus_tag="BJ961_RS20210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_271414189.1"
                     /transl_table=11
                     /translation="MTAQTANSQVDEYEAAVLRLRDVGVRRFTTDQLILDGVDWTVRPG
                     EHWALLGANGAGKTTLLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVNSAQRV
                     PQDLTAHAVVLTGHSGTVQPLWRTYDDEVRLRARDLLTELGVKELADRPYGVCSGGQRA
                     RVLIARALMADPALLLLDEPFNALDLPSREDLVEAMHQLAEGRTQLATVTVTHHLEELS
                     PAVSHALLLREGRIMSRGAVDEVLTDSRLTACFGRDITVARRDGRWSAYSGRRVSGT"
     gene            19870..19944
                     /locus_tag="BJ961_RS36185"
     CDS             19870..19944
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042934.1"
                     /locus_tag="BJ961_RS36185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative leader peptide"
                     /protein_id="WP_356626429.1"
                     /transl_table=11
                     /translation="MRRFRQFTKRRAIDLMRVATAVCC"
     gene            19994..21070
                     /locus_tag="BJ961_RS20215"
     CDS             19994..21070
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994291.1"
                     /locus_tag="BJ961_RS20215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_271414190.1"
                     /transl_table=11
                     /translation="MTSRTRMPGFRRLSVLAALALPLTLASCVTPAQSTTGGRDLSRER
                     IPAAVDPGTTLTVGAPDLRVALELSGQADRLPFKVKWANISGGPQCSEAFRADALDICS
                     AADIPSINAHWTGLDTKLVAVKFRTDPVAHPVYELGTAPGSGIRTLADLRGKKIAYSPG
                     QAQGALVLRILAKAGLTQQDVELVELASTGDVYPTALGNRQVDAAPIADVNIKRYLAHY
                     GEEGGATIRHGLRDDPAHLWALTESVADAQKSAAVRELVRFWARAQTWIDQHPREWVAG
                     YYVKDQGLDREDGAYLVRRVGHPDLPADWTDAIRRQQQTIDLLAEEQNREPFDADQLFD
                     RRYEAVAAQALAGEGTPS"
ORIGIN
        1 ggcccggccg cctcctggcc tgcgcgctcg cgctgtacgc cacgggactg atcgcgatcc
       61 tcctcggcct gggccgcgtt ccgacggcct gcgccgtcct gctcgcggtg ttcacggggc
      121 tgctgggtcc cgcgctctcc ggcggctgga ccgcgcagtt gccccgggtg gcggcgggcg
      181 gccacctgcc ccgggccaac gcgctggacg cgatgacctt cagcgcggcg agcctggccg
      241 gtcccgccct ggccggcggc gtggcggtga ccctgggggc ctccacggcg gtcgtggtcg
      301 ccgcggcact ggtggccgcg gcggcgcccg ccgcgtggcg cctgccgacg cgtccgcggc
      361 cggccccggg ggacggccgg ccgccgtgac cggcgcgctc gccgccgggt tccgggtcat
      421 cgtccggcgc ccgcttctcg cccgggcgac gtacacctcg gtcgtctgct gcgtcgccca
      481 gggcatgctg gcggcctgtg tcccgctcct gggcgcacgg gttctgggcg cggccgggcg
      541 cggcgccctg ctgctctcct gcgcggccgt ctccgccctc gcggccaacg ccgtactcgc
      601 ccgccatccg cgcgccctcg ccccggacac ggtcgtccgg gcctcggccc tggtccaggc
      661 ggcggcgttg gccctggcgg ccaccggtcg gcccgcgatc ctcctggtgg ccgcactcgt
      721 cctgggcgtc ggcgaaggcc cccagctcac cgcgctgttc gcggtacggc accgggaggc
      781 ccccgatcgg ctgcgcggcc agatcttcac caccggggcg agcctcaagg tcaccgcgtt
      841 cgcgctgggc gcggccgtcg ccggcccgtt ggccacgtgg tccctgccgg gcaccctgac
      901 ggtggcggcg ggcacggcgg tgggcgcggc ggcgggtgcg gcgttcgtcg gccgcaaacc
      961 gtttgacggc cctccgcgtc cgggggtcgg atgaggccca tgggttcagg gtggacgcag
     1021 ccggccccac gcgacctcga cgaccgactc gtgcggcggc tgatcgccga acagttcccg
     1081 cggtgggcgg ggctgcccgc ccgggcggta ctcgccgaac cgggctaggg cgcgatgccc
     1141 acgccctcga tcctgctcca cgcccgctcc tgagcggcgg tcatggcggg ccaggcgagg
     1201 ccgcccggcc ggggccgcac ccgcgaggcg tacgcggagg gctggaagcc ggggtcgtag
     1261 aagcagccct caccgtacgt cgcgtcgaag gcgctgcagg aggcggcgat cgcccgcggg
     1321 ctcggcctgt gccccgtgcg cacccagctg tccagcgcgg agagggagtt ggcgtactcg
     1381 gagtcactca gcgagctgtg ctcgtgctcg ttcgtgaagg tctggacgag gttcccgtcc
     1441 cgtccggccc cccggagtgt ggcgcggtag gccgcctcgt gctccacgaa cgccgtcggg
     1501 tcgtcgatgg cgtgcagggt gaggacgggg agggagaccc tgccggtgag gtcgctgtcc
     1561 caggacaggt cacggcgtgc ggtggggtcc gccgagaagc gtgcgacgcc cgcgttgagc
     1621 gccttgtcgt cgtgcgagcc ggtgtagcgc acaccccggt tgctccaggg gttccgcccg
     1681 ccgagccggt cggtcacgat gtcccggaag gtgaaggtgg cgaacctcag atgtgattcc
     1741 agggtgcgct cggggatgcc cgtgacggcg aggatgtcgt ccaggttgcg ctgctgcggt
     1801 gcggtccggt ccgccgcttc ggaggcgtag cccgtgcact cctggaggcg ggcgcgcagc
     1861 ccggcggtcg tcatcgtgga accggcgcgc aggccctgcc acaacgggta ctgcggctcg
     1921 ctcggccgcg ggtggttgtg gcagtagtac tggtagacca cccgcaggtc cacgcggtag
     1981 tcgtagccgc gcgaaccgcc gccgaggacg ccgttggtca gcagcacccc gtcgtaggca
     2041 ccggggcgcc ggccgtaggt ctcggcggcc ttggcggcga cgttgccgcc ccaggactgg
     2101 ccgtgcaggt aggtgcggtc cgggcggccg aagcggtcgg tgaacacgcg gcgcacgttc
     2161 tcggtgtcgg cggcggccat gcgggccccg tagccgccgc gccggtagga ggagccggcc
     2221 caggcgtatc cctggtcgac catcaccgcc cagcgttcca ggtcctcggt gctgcgggcg
     2281 gggtcggagg tgtcgccgag gtcggggccg ccgtgggcgt gcacgacgag cgagccgttc
     2341 cagcggtggg gcacggccat cgtgtagtgg gccccgttcg cgtcctggcc ggtgtagcag
     2401 gtggccttcc cggcgagggc gggcgggcag tcggcggtca ccggccgctc ggccgcccgt
     2461 gcgggggcgg cggagacgtt gccgagggtg ccgaggaaga cggcggcgag cgcggcggcc
     2521 acgaccgccg gacggcttct gcggtgcatg acccgggcgt cgtgcgtggc tgcttcgggt
     2581 gtggacaagg tgcggctcct gtacgtgctc tgctgctgcg gtccggcgcg agtcgcgctg
     2641 cgagcaggga tgttaggaac acggcggagc cggagccacc ccttccgccg ttgcgttcat
     2701 agtgttcgcc cggaaaccct cgcccacggc ggcaaccccg cctgaacggg cgggaaccga
     2761 cgcccggtca gctgtcgtag tccacggtca ccttctcgga gaccgggtac gactggcagg
     2821 tcaggacata gcccgcgtcg acctcggccg cctcgagcgc gtagttgcgg cgcatgtcga
     2881 cgctcccgtc ggtgaccagg gcccggcagg ttccgcagac cccgcccttg caggcgaagg
     2941 gcaggtcggg gcgggtctgc tgggcgccgt cgaggacgga gcgctcccgg gagagggggg
     3001 aggtcgtgga gcggccgtcc agggtgacgg tgacctcgct gacgggcccc tgcggaccgc
     3061 tgtcctcgtg acggacctcc cgcacgggct cgtcgtcggc gaagaacagc tcccggtgga
     3121 cgcgctccgc cgggacgccg aggccggtca ggacctgctg ggcgtcggcg accatgccct
     3181 gcgggccgca cagccaccag tggtcggcgg ccggcacgtc caccagggag tcgaccagcg
     3241 cggagagtcg tccggcgtcc aggcggccgg agagcacctc ggcctcgcgg ggttcgcggg
     3301 agagcacgtg ggcgaggtgg aagcgggtcg ggtggaggtc cttcaggtcg gccagctcgt
     3361 cggcgaacat caccgtgtcg gtgcggcggt tgccgtagaa gagggtgacg gtggagcggt
     3421 cgtcggcggc gagcaccgac tcggcgatgg acaccatcgg ggtgatgccc gatccggccg
     3481 cgatcaggac gtggtggccg ggggcggtca ggtcgggggt gaagaggccg gtgggcgcca
     3541 tcacttccac ggtgtcgccc ggccgcacgt cctcgaccag ccacgccgag aacagtccgc
     3601 ccggcaccac ccgcaccccg atgcgcggcg ccgagccggc cggtgcgcag atcgagtagg
     3661 agcggcgctc gtcccggccg tccacctcgc gccgcagggt gagcgactga ccgggcgcga
     3721 aggcgaactc gccggccagt tcgcgcggga tctcgaagct cacggccgcc gcgtccgcgc
     3781 acagccgctc gacggccgcg acgcgcagac ggtggaaggc gggccggcgg cgggtgcgca
     3841 ccggggccgc cgggacgggg gcggtcgggg ccatcagatc tccttgacgt actcgaacgg
     3901 ctcgcggcag gcccggcagc gccacagcgc cttgcaggac gtggcggcga agcgggaggt
     3961 ctcctcggtg tccgccgacc cgcagcgcgg gcagggcacc gcgggccggg tgggcgacag
     4021 gaccagggag acggggcctc ggggtgcggc ccccggcggg gcgatgccgt gctcggcgag
     4081 cttcaggcgg cccgacccgg tgatccagtc gctggtccag ggcgggtcca ggacggtgcg
     4141 gatctcgacg cgcgcgtatc ccgcccgccg cagccgcgcg gcgacgtccg cccgcatctc
     4201 ggccatcgcc gggcagcccg agtaggtggg ggtcaggctc gcgaccacgg tgccgtcctc
     4261 gccgacctcg acgtcgcgca agacgccgag gtcggcgagg gtcagcatgg gcagctcggg
     4321 gtcgggcacc tgctcggcga cgtgccgggc gcggtgggcg tccaggagtg cggggccgcc
     4381 ggtcaccatg tcgcctccgg gtgggcgcgg gcgacgccct gcagctcggt gaggagcggc
     4441 gccaggtgtt cggtgtgctc gcccgcgcgg ccggaccccg gcagcggacg gtggacgggg
     4501 agggtcagtc cggcggcctc cgtgacctgg cgcagatcgt cggcgacctc gtcccgtacg
     4561 tcgtacgccg tgtgcagttc gccgaggtag ggggcgacct cgtccagcgc ggcgcgcgtg
     4621 cggcggtgcg actcttcggt gccgtcgccc aggcgcacgc accactcggc ggcgtactgc
     4681 cggtggtacg tcagctcctt gacgcccttg gcggcgaccg ccgcgagcac cgggtcgggg
     4741 tgggtctcga ggcgccggaa gtgggccagg cgccagctgg agaggaccag cagtcgcacg
     4801 accgcgaacg cgaagtcgcc gcccgggagt tccgccaggc ggatgttgcg gaagtcgtcg
     4861 gcatcgcgga agtaggcgta cgcgtcctcg ccgcggccgg tgccgtccac ctgcccggcg
     4921 cgggagtaca gcaggcgggc ctggccgagg aggtcgaggc cgatgttggc cagcgccacc
     4981 tcctcctcca gctccggggc gcgggtgacc cactcggcga gccgctgggc gctcaccagg
     5041 gcgtcgtcgg cgagcgccac gcactcggcg gccagttcac cggcgtcgac gccctcgggc
     5101 acggtggtgt cgacgccgtg cagcgggtcc tcgaagccgg tgccgtaggc ccagcgggtg
     5161 tcgtcctcgt gcccctcggc cagggtgagg tagacgtggt cgtcactcat gccctgctcc
     5221 tagatgtggg ggacgtcgtc ggggatgtcg tagaaggtcg gatggcggta gaccttgtcg
     5281 gcgctggggg cgaagaaggg gtccttctcg tcgcgggtgg aggcggcgat gtgctcggag
     5341 cgcaccaccc agatgctcac gccctcgttg cgccgggtgt agaggtcgcg ggcgtgggtg
     5401 agcgccatgg cgtcgtcggc ggcgtgcagc gagccgacgt ggacgtggtt gagtccgcgc
     5461 ttgccccgca cgaacacctc gtacagcggc cagccctgct tctcgtacgt ctggggcttg
     5521 tcggcgctca tgccgccgct cccttctccg cgcgggcggc ctgcttggcg gcgtgggcgg
     5581 tggccgcctc gcgcacccag gcgccctcct cgtgagcggt gcgcctccgc tccatccgcc
     5641 ggtcgttgca ggggccgtcg cccttgatga cgcgcatcag ctcgtcccag tcgggggtgc
     5701 cgaagtcgtg gtgtccgctc tcctcgttcc agcgcagctc cgggtcgggc agggtgacgc
     5761 cgagcttctc ggcctgcggg acggtcatgt cgacgaagcg ccggcgcagt tcgtcgttgc
     5821 tgtgccgctt gatcttccag gccatcgacc gcgccgagtt gggcgaggcg tcgtcgggcg
     5881 ggccgaacat catcagggac ggccaccacc agcggtccac cgcgtcctgg accatctcgc
     5941 gctgggcgtc ggtgccgcgc atcatcgtca tcagcagctc gtaaccctgc cgctggtgga
     6001 aggactcctc cttgcagatg cgcaccatcg cgcgcgcgta gggcccgtag gagctgcggc
     6061 acagcggcac ctggttgcag atcgcggcgc cgtccacgaa ccagccgatc acaccgacgt
     6121 cggcgaagct cagggtcggg tagttgaaga tcgacgagta cttctgccgt ccctcgatca
     6181 gccgctcggt gaggtcgtcg cggtcggctc cgagggtctc ggccgccgag tacaggtaga
     6241 gcccgtgccc ggcctcgtcc tggaccttgg cgaacaggat cgccttgcgg cgcagcgacg
     6301 gcgccctggt gatccactcg ccctcgggct gcatgccgat gatctccgag tgcgcgtgct
     6361 gcgcgatctg ccggatcagc gtcttgcggt agccgtcggg catccagtcc cgcggctcca
     6421 cgcgctggtc gcgcgcgatc gtcgcgtcga agtgctcctg gagcccgtcc ggcgcgtccg
     6481 ggggcggtgc ctcggcggcg tgtgtcgtgg tcatcgtcac cagcttccca accgaccatt
     6541 cgttcggtat cagtgtgtcg cgtttccgtt cgccgggcaa gagccggggc cccgccgtcg
     6601 cactcttgac agcgccgccg cgtggctgga ttacttggcc gtgccgcgag ctaaccgaat
     6661 ggtcggtcgg gagacaaggt ggtgggtacg gtgtcgcagg ccactgagca gacgcccgcg
     6721 gaggtgatgt tcgccgcgga cgaggcctca cgggggctgg gcatcgagct ggtcgagcac
     6781 ggcgaaggga ccgcggtggc caggatgacc gtgaccccgg cgatggtcaa cgggcaccgg
     6841 atcgcccacg gcggcttcct cttcctgctc gccgacaccg ccttcgcctg cgcctgcaac
     6901 agccacggac cggtgacggt cgcggccggc gccgacatcg tcttcgtcgc cccggcccgc
     6961 gagggcgacg tgctggtcgc ccgcgccgag gagcgcgccc ggttcgggcg cagcggcatc
     7021 tacgacgtga gcgtgtggcg cggcgacgag ctgatcgcgg agttccgcgg ccgcagccgc
     7081 agcgcccggg acgacacggc gcgcgagacg ccgggcacga cgacgaagga gtcgcgatga
     7141 gcagcgagcc gacgaccggg gcggccccgg cgccccgacc gggcgagccc ctcccccacg
     7201 acctgctcga cgacgccgag cggctcaccc gcgagcagct ccgtgagctc cagctcgacc
     7261 gcctgcgcgc gaccctgcgg cacgcctacg accacgtgga gctgtaccgc aagaagttcg
     7321 acgccgccgg ggtgacgccc gaggactgcc gcagcctggc ggacctgtcc cggttcccct
     7381 tcaccaccaa ggccgacctg cgggagacct accccttcgg catgttcgcc gtcccgatgg
     7441 cggacgtacg gcgcctgcac gcctccagcg gcaccaccgg ccgcgccacc gtcgtcgggt
     7501 acaccgacaa cgacctgtcc atgtgggccg acgtcatcgc ccgttccatt cgcgccgccg
     7561 gcggccgccc cggccacaag gtgcacatct cctacggcta cggcctgttc accggaggtc
     7621 tcggcgcgca ctacggcgcc gagcgcgccg ggtgcacggt gatcccggcg tccggcggcc
     7681 agacggcacg tcaggtgcag atcatccagg acttccggcc cgagatcatc atggtcaccc
     7741 cgtcctacct gctcaccctg ctcgacgagt tcgagcggca gggcatcgac ccgcgcggca
     7801 gctccctgaa ggtcggcatc ttcggcgccg agccgtggac cgaggagatg cggcgcgaga
     7861 tcgaggagcg catggacatc cacgccgtcg acatctacgg cctgtccgag gtgatcggcc
     7921 cgggcgtggc gcaggagtgc gtcgagacca aggacggact gcacatctgg gaggaccact
     7981 tctaccccga ggtggtggac ccgctcacgg acgccgtgct gcccgagggc gaggaggggg
     8041 aggtcgtctt cacctccctc accaaggagg cgctcccggt gatccgctac cgcacgcgcg
     8101 acctgtcccg cctgctgccc ggcacggcgc ggcccgcctt ccgccggatg cggaaggtca
     8161 ccggccgctg cgacgacatg atcatcctgc gcggggtgaa cgtcttcccc acccaggtcg
     8221 aggagatcgt gctgcgcacg cccggcgtcg ccccgcactt ccagatccgg ctcaccgccc
     8281 gcggccgcat ggaccacatg accgtacggg tcgaggcccg caccgacgcc ggcccagagc
     8341 agcgcgaggc cgccgcgagg gcgatcggac agggcgtcaa ggacggcgtg ggcgtcaccg
     8401 tggaggtgga ggtcgtcgag ccggagaccc tggagcgctc gctcggcaag atccgcaggg
     8461 tgtgggacat gcggagcacg tgaaacgtga tcacggacac gcccgttcat cagccgtgct
     8521 ggtgtgcgag gagatacgga tgggcagtaa gtgcatgatc gggggaggtt gagtacatcc
     8581 tggggggaca tcccgtgcgt gtgtgtgtga tcggtgcagg cctgtcgggg ctggcggcgg
     8641 cccatgccct gaaggagcgc ggcatctcct tcgtctgcct ggagaaggca cccgacgtcg
     8701 gcgggatctg gcgtcagccg ggagccggcg agcagggccc gggctaccag accctgcacc
     8761 tgaacaccgc caagcagctg acgggttacg cggacttccc catgccgtcc tcgtacccgc
     8821 tctacccgcg gcacagccag ttcgccgcct acctgcggtc cttcgccgag tgggcgggtc
     8881 tgctcggtca cgtcgagctg cggaccgagg tggtgtccgt ccgccgggac gcggacggca
     8941 tgtggaccgt cgtcagccgg ggtgcggacg gcgccgagac ctcgcggcgg ttcgagcagg
     9001 tggtcgtcgc ctcggggcac cacaccgacc ccgccctgcc cgatcccctg ccggccggcg
     9061 ccgactcctt caccggaacg attctgcact ccctcgacta ccgcgacggc ggcgacttcg
     9121 ccggccggcg cgtggtcgtg gtgggcctcg gcgcctccgc ggtggacatc gcggcggacc
     9181 tctcccggca cgcggagcgg accctgctgt cggtgcgccg ggggctgcac gtcgtaccca
     9241 agcagctctt cgggatgtcg gtcgacgaga tcgccgaggc cccctggtgg aacgagatgt
     9301 ccttcgccga gcggcgccag tgggtggagc aggctctgct ggtggcgcgc ggcaggctgt
     9361 cggactacgg cctgcccgag cccgaccacc cggtcttctc ctccgccacg accctctcgg
     9421 acgagatcct cagccgcatc cggcacggcg cggtgacccc gaagcccgcg atcgcctcgt
     9481 tcgacggcga ccgggtcgtg ttcacggacg gcagttccga ggcggccgac gcggtcgtct
     9541 actgcaccgg cttccgcatg accttcccct tcctgcccgc cggctgcccc gtctcggcgg
     9601 acggctcggt cgagctgtac cggcgggtcg tgccggcgga ccggcccggt ctgtacttcg
     9661 tcgggctggt gcggcccgtg ggcgcgatca cccggctggt ggaggcccag gcggagtggg
     9721 tggcgcggat catcgacggc gccgccccgc tgcccccggc cgaggagatg cgcgaggaga
     9781 tcggtacgta cctcaccggc atcgtccagc gctacggccg gaccgagggc gcctcgatcc
     9841 aggtcgacgt gggcccgtac ctggccgagt tccgggaggc gctgcccgtg tgaccgtccc
     9901 gccgggcgcc ccgcgcggtc ggcggcggca cccggccgcg tccgcgcccg gggctcccgg
     9961 tggatcgcgc cgggagcccc gtcgtgtgcg cacggtccgg tcaggacacc ggcagcggtc
    10021 ggcggacggc ctccaccacc ggcggccgca ccgcgtacgc ctccgaggag aggtacgccg
    10081 tcacccgcgg cgcgctgccc cgctgatggg cgagggccag gtaggcgatc agccccaccc
    10141 cgtcctcggg ccgccgctcg gtgagggcgg ccagggcgcg gtcgagcacg tcggagtcca
    10201 tgccgtgatg gcgcagcacc ctggatgccc tggccagcac ttccccgtcg tgccgggcgt
    10261 agtccctgac cgggatgtgc agggtgaatc cgctcggccg cgcggtggtg gtgtcggtga
    10321 aggagtggca ggtcaggccg ggcctcctgc cgagccccgc cgtgtcgggg ccgagtccgg
    10381 cggccgtgcg gaagaacccc tcgacggccg cgggccccgg acccgagtcc gtccgggaca
    10441 ggcgcccggc ctggccggcg gtgaggttct cgtgccgtac gtagaccttc acccggggct
    10501 ccgcccagtc acccaggtcc agggcgagga acgggtgtcc gctgcccttg ggcaggctgt
    10561 cgtaggcacg gcggtggccg agcctgtgca gggcctcgcg caccgtcgcg gcggaacgtt
    10621 cctccccgtt cgccgccggg ttcaggtaca ccttcaccct gggtacgccg ccgggcgtca
    10681 gctccagggc gcaccacagg gcgagggggc cctgcggtgc gtcgggcagg aacaggtccc
    10741 ggacgtcgtc gagggcgtcg gtggtgaagt tccagcgccg cgccatgtca cggaccgccc
    10801 ggagtccggc acgcccgccg agagccaggc tgtctgcgcc gcagccaggt tccaggagca
    10861 cccgcatgga gggtgcggcg tcgggccgga aggagaggga gaactccacg ggggtgtggt
    10921 cgtcggacag gaaggtgcgg tggggcggcg gcaggttcag cggccgttcg gcctccgggc
    10981 ccagggtgtc ggtcaggacc tgtgcgtagg tctcggcgtc ggccccggac aggccggcga
    11041 ccgcgccgag tcttcgcagc tgaccgctgg tgaaggaacc gagcgtcggg gtgccccgcg
    11101 ggcccgcgcc cgtcggtgcc gcgctcaccg gcccgtcccg tgtcggagcc gcacagagcg
    11161 atacccgcct cgggaggcgg gtatcggggg gttcggcgcc gggaaagcgg cgtacgtgga
    11221 tatgtggtcc acgacacctc cttttactcg taagcaactt gaatgccgcg ttgctcacta
    11281 cccgtgccgt tggatcttca tgcgggaggg gcgggtcgga caggtgttgc gcacatcacc
    11341 gtgtgagcca gttgaggaac tggctccaca tgccgttgcg ttcggtcggc cgggccgcgc
    11401 ccgtcgcctt gtcccgctcg gccggggccc cggccgacag cggctcggca cgccgcgagg
    11461 accgtgccgg ggtgaagcgg gccggaagtg tggccagggc ccggttgaag gggcccggac
    11521 gccacgtcag actgtcctcg ggtacggcga gttggacgtc gggcagctcg ttgaggaggt
    11581 gctcgatggc cgtgacggtg atgtgccggg ccggttcctt ggacgggcag gcgtgcgggc
    11641 ccgcgctcca ggcgaggtgc gcgcggttgc tgccggcctg gcgggaggcc ttgagggtcg
    11701 ggccggtgtt ggccgcggcg aaactgacca ggacgaggtc gccggcctcg aggtgctgtc
    11761 cggccagttc ggtgtcggcg gccgggtagt gcggggcgta gttggccatg ggcgggttct
    11821 cccacagcgt gtcgtcgatc gcctcgtcga tcagaccgcc ctcgcgtgcg taccgctcgt
    11881 gggtgaggag ccggtgcagg gtgttgccga ggaggttgcg caggggttcg gcgccggcgc
    11941 cgaggagcag cgcgagctgg tggaccatct cctcgtcgtc gagaccggcc tcgtgccgca
    12001 tcagccagga ggtgacgtcg tcgccgggct tgcgccgctt gagcgcgacg agttcgccca
    12061 ccgcctggaa gagcaccgcg gtggccttct cggcgttgac gccgtcgaac atgccggaga
    12121 tgccgaacag cacccggtcg ccgatgtcgg cggggcagcc gaagagttcg ttgaacacga
    12181 acagcggcag ctgcttggcg tagtccccga gcaggtcggc cgaaccccgg gcggcgaact
    12241 gggagatgag gtagcccgag atctgctcgg tgctgcggct cagccgtcgg gtgtccaccc
    12301 gcgccatgct gtcggtgacc gcctgacgca acctgatgtg gtcggcgccg tcggcgaaca
    12361 tgcagttggg ccggtaggcc agcaggggcg cgaccgggct gtccgggccg accttgccct
    12421 cgttgaaggc acgccagcgg cgggcgtcct tgcggaagga cccggagtcc tgcagcagtt
    12481 ggagcgccgc cgcgtagtcc gtgaccagcg tcgcctcgac gcccggggcg agttcgacgg
    12541 gggccgcggc cccgtagtgg cgcaggtact cgtagtacgc ctgcgggtcg gcggcgaact
    12601 ccggcccgtg cagcggcacc cgggcgccgg agccgtgggc cgggcagccg ggaggcggca
    12661 ccggggcggt gtcgtgggcg ttcatgtctg ctcccagctc ctagcgggtg cggtccagca
    12721 agtagcggac gagggtggtc agtgcggcgg ccgacgactt ctcgtcacgg gcgtcgcagg
    12781 tgacgacggg ggtgtcgtcg agcaggtcga gtgcctcgcg cagcgccggc tcgtcgcgcg
    12841 ggggcgtgcc ggcgaagtgg ttgacggcga tggcgtagtc gagtccgtag tgctcgatga
    12901 ggtcgatcac ggggaaggag tccgccagcc gctccgggtc gaccagcacc agggcgccga
    12961 gcgcgccgcg ggccatgtcc tcccacatct gcacgaagcg ctgctgcccc ggggtgccga
    13021 agaggtagag cacgacgcgg tcgctgatgg tgaggcggcc gaagtccatg gcgaccgtgg
    13081 tggtggtctt gctccggacc cccttgaggt cgtcgaccga ctcggcggcc tgcgtcatcg
    13141 tctcctcggt ggacagcggc tcgatctcgg agatggagcc gatgagggtg gtcttgccca
    13201 ccgcgaagtg cccgacgacg aggatcttca ccgccgtctg ggtcgctccc tcgcgtacgt
    13261 agtcccgttc acccaaactt ggcgcggagc ccattgagca cctcctccag gatctctcgg
    13321 tccgcgagac gggcgcgggc caccggcggg cgggtcgtga ggtgtccgcc ctccatcagg
    13381 gaggccagca ggatccgcac cacgcccagc gggaaatggc tgtgtccggc gatctcggcg
    13441 accgagaggt agccggcgga gcagaggtcg agcaggctct gctcctccgg ggagagccgg
    13501 gcgggacgcc gtgtgtcctc ggccgacgcg gtgaccaggg tgacgaggga gaggtcgtcc
    13561 tcgtcgggca ggccgcgccc cttggtgatg acgtactgcc ggactaattc gggcgcctcg
    13621 ggctgccagc cgtcgtggcc ggtcatgagt gggcgccgag gttctcgcgc ggcggtgtcg
    13681 tcagccgctt gccgagctgg ccgacgagct gctgcatccg gaaggtgatg tcggccatgt
    13741 cgacctccgg ggaggcggac acgccgaggt aggcaccctc gccggcggag atcaggaaca
    13801 cccagccgcc gtcgaactcg acgagggtct gccgccacgt ctggctgggg tcctcacaga
    13861 agaacgcgag ggtgcggctg agcgactgca cgccgctcat ggcggcggcg acccggtcgg
    13921 cgtcgtcctt gccgaagtcc tgcgtccggg ccatcaacag gccgtcggcg gatatcagga
    13981 ccgcgtgcag ggcgcctgga atctccaggg cgctgtcgag catccatgac agatcgtcgt
    14041 tcacgagacc tcatgtcctt cgctgcttgc accaggtgtt ctgctcgtcc ggccggtgtt
    14101 gtccccgggc ccctgctcgg tgacccggcc ggactgcgtt ccgcgctgga aggcacccat
    14161 gacctgtgcc tgctcggagt cggagcggcc cgccgggcgc ggggtggacg cgctgccggg
    14221 gacgatggcc atcggccgct tgcggcggcg ccggggcagg ccgtcgccgg tctcggagga
    14281 ggaggcgagc gaggcggact ccggtccgcc ggcgtcctgg accggccggg cggtgccgcg
    14341 ggcggccggg gcgggcgcct tcttctccgg catggcggtg agcagttcgt gcgggagcag
    14401 gaccaccgcc cgtacacctc cgtaggggga ggaggagtcc accgacacct cgaagccgaa
    14461 tcgctcgcag agcaggccga tgaccgcgaa gccgaactgc ggcgggttgc cgagccccgc
    14521 cactcccgag gcacgctcgg tggcgagcag cttgtcggcc cgggtccgct cctcgtcgct
    14581 catgccgaca ccggcgtcgt cgacgacgac gcagatgccc ttgggcacgg tccggatgtt
    14641 gatctcgacg acggtgtccg ggctggagta gctggtggcg ttgtcgagca gctcggcgag
    14701 ggccagggcg acgggctcca ccgcccggct ggtgatgccg aagtcgacct gggagaggat
    14761 ctccacccgg cggaagtgcc ggacccggcc ctgggcgctg cgcaccacgt cgtacaccga
    14821 ggcggtgtcg cgccgcccgc ccagccagcc gtcgcacagt acggcgatgg actgggcccg
    14881 ccggccgaac tgcgagttgg tgtggtcgat ctccagcagg tcctggagga gggccgagtc
    14941 gccgtacttg ttctgcagcc gggagagcac cagttgctgt tcggcggcga ggccctgaag
    15001 ggtccgcatg gcggatttca gcaccgtctt ggtctcgtcc tcggcccgct cctgggcggc
    15061 cagcaccgac ttcccgtaat cgttctccag ctcggtgtag tggtccctga gcccctggac
    15121 ctgctgtcgc aacgctcgcg ccgccctgcg ctggcggctg acgagcacgg cggcggcgac
    15181 gagggcgaca agggcgaccc agagcaaggg gttccctgtg tattccgtca taagactctc
    15241 ttcaggcgac tgacagccgg cttgcggctt gctgaattcc cgtccacgcg ggcggcccgg
    15301 tggactgccc gcaccggggg tgactgcccg ggctgtccct tacgtcgggg atgccgtctt
    15361 tcacccatcc gcccgctccg caaacgcggt gatcgtatca ccgcgtgatc aggtgaattt
    15421 acgtcaagaa gtgcgcactc aggacgggtt ggagaccggt tcggatgccc tctccgacag
    15481 tgggtacagt cggccccgtg aaagatgcac aagacacctt ccggccgagt acgggccggg
    15541 cgcggaacgg cacggcgtga cgcctgaggc catggcgggt gtgttcgccg cgggtgtcgg
    15601 cgccggcgcc atcaacagcg tcgtcggttc cggcacgctg atcacctttc ccgtgctgct
    15661 ggccacgggg ctgtcgccgg tcacggcgac cgtctccaac gccctcggtc tcgtccccgg
    15721 ttccgtcagc ggggccatcg gctaccgcag ggagctgcgc gggcagcggc ggcgcgtcct
    15781 gaagctgggc gtcggctgcc tgctgggcgc gctgacgggc gccacgctgc tgctgtccct
    15841 gccggccgac gcgttcgaga cgatcgtgcc ggtcctggtg ggcctggccc tggtcctcgt
    15901 ggcgctgcag ccccggctcg ccaagctggt gcagcgccgc cgcgagcgct ccggcgcgcg
    15961 gccccgtcgc gacggcggcc cggcgctgtt cgccgggctg acgctggcca gcgtctacgg
    16021 cggctacttc tccgcggcgc agggcatcat ctacctgtcc gtgatgggca tgctcctcga
    16081 cgagccgatg caacgcctca acgccgtcaa gaacgtcctg tccgccctcg tgaacacggt
    16141 cgccgcggtc ttcttcctct tcgccgcgga cttcgactgg accgccgtcg cgctcatcgc
    16201 ggccggttcg gggctcggcg ggtacgtggg cgccaaggtg ggccgcaggt tcagtccggt
    16261 cgtcctgcgg acgctggtcg tgacggtcgg caccgtggcc ctcgtgcaac tggtgctccg
    16321 ctagtccgcg cggcggcagg gtgacggggc ggcggcccac gagactcagg acaagagtgg
    16381 aacctgcccc gccgcttgcc ctcgcacacc tcttccgccc acccggcgga cgtggcgtgg
    16441 accacgccgt cgcgcggatt gccaccggga gcgatcgggg aagccatgga ggcgcccatg
    16501 atcgactcga agggacacgc cctcgtgacg ctcgtagcgc ctccccccat acccagggca
    16561 gcgggctcgc tgccgtttct gggtcacgcg acacagctca tgcgcgacaa cctcggcttc
    16621 atcgccgcgc tgcgcaccac ctacggccca ctcgtcgaga tcaccctcca gcccggcacc
    16681 cgcaccctcg tggtccagga ccccggcctc atccgcacca tgctcaccga cctgggaccg
    16741 agcctcgaca agggccggtt cttcgagaag atgggacagc tgctgggcga ctccgtggtc
    16801 accgcggccg gccaggtcca cgtccgcaaa cggcgccacc tccagcccgc gttcgcccgt
    16861 gagcgcatcg cccgctacgt cgacaccatg cgcggcgaga cggacgccgc cgtcgacggc
    16921 tgggtccccg gccgcgggct ggacgtgcgc gaggcgatgg tcggtctcag cctggacatg
    16981 ctggccaaga ccgtcttctc gggcagcctg gacgacgcca ccttccgccg gctgcgcgcc
    17041 gacctgtcgg tcgtgatgaa cggcgtcggc gcccgcgtca tgctgcccga ctgggtggag
    17101 cggctgccgc tgcccgccaa ccgccgcttc ttggccgcgc gcgacgccgt acgggccacc
    17161 gtcgaccggg cggtgaccga actccaggac tccggtcacg acaccggcga catgctctcc
    17221 ctgctgttgc gcaccaccga cgaggagacc ggccggccgc tgtccgggca cgagatctcc
    17281 tccgagatcc tcacgctggc cgtggccggc accgagacca ccgcctcggt gctctcctgg
    17341 gtgctgtacg aactcgcccg cgatcccggg atcgaggcgc gggtcctggc ggaactcggc
    17401 gaggtgctcg gcgaccgtcc ggtggccttc gacgacctcg gtcggctgcc gtacctgagg
    17461 cgggtggtcg aggagacgct gcggctgcac cacaccgggt ggctcgtcac ccgccgcacc
    17521 gtcaccgaga ccaggctcgg cccctggacg gtgcccgccg ggaccgaact ggcctactgc
    17581 cagcacgccc tgcaccgcga cccggtgctg ttccccgacc cgctgaggtt cgatcccgac
    17641 cgctggctgg acgactccgg gccccggccc acgcaggcgt tcctgccctt cggcgcgggc
    17701 aagcacaagt gcatcggtga ccggttcgcc ctcaccgagc tcctcaccgc caccgccacg
    17761 atcgtgcggc gcgtacggct ggagctcgcc cccggccaga cggtccggcc ggtcgccgcg
    17821 gccacggtcc ggccccggac cctgctgatg accgtgcgcc cgagagcgga cgccgccgcc
    17881 ccggccgccg gctgaggaca ccgggcccgg ccgggcccct cccccggccg gcccggactg
    17941 ccggggcata acgccgtgtt atgccaagtc gggattgttc gcgccgcggc cgggccggac
    18001 atgctgggcg cccccacaca tcagcacgcg tccagcgcgt gccgtcggaa acgaggagcc
    18061 ttgcgaacca cgagactcgt ccccaccgtg ctggccgctc tcctggccgc gctgctgtcc
    18121 gcgctcgcac tcgccccgac cgcctcggcg gtggagcccc ggcccggtga cggcggcccc
    18181 cggccgatca tcggcggcgg ctacgcgcag aacgccccct gggcggcacg gctgttctcg
    18241 ggcggccagc agacctgcac ctcgaccatc atctccccca cctggatcct caccgccaag
    18301 cactgcgtca gcggcggcaa cctcgccttc cgcatcggca gcctcgacca gggctccggc
    18361 ggcacggtgg cgaacggcgt ccagaccgtc accagcccct cggccgacct cgcgctggtc
    18421 cggctcgacc gctccgtctc cgcctcctac gcacggctcg ggcagccggg cacggtgcgg
    18481 gtcggccaga ccgtccaggt ctacggctgg ggagcgacct cccggtgcgg ctcggagatc
    18541 aactgccagt cccagtacct caaggtggcc aacgtgagcg tcacccaggg ctgttacgac
    18601 gcctactacg gtcaggcgat atgcgcccgt cccgtcgacg gcatcaccgc gggcggcgac
    18661 tccggcggtc cgatgatgtc cggcggcgtc caggtgggcg tcgcctcgac cagcgaccgc
    18721 cagtccacca cggcgtacac caacgtgacc gcctaccgct cgtggatcca gtcggtggcg
    18781 ggcgtctgac cgcctccgct caccaaggtc cgcccgcccg gcccgggcct gtcggacgtc
    18841 gtcgtcgggc cgtccaggaa ccggacggcc cggcaggcgc gtggtccgta catctactgt
    18901 tcacggtgac cgaggagagt cccgcgcgcg aaggagccac ggcatgaccg cccagacagc
    18961 caactcccag gtggacgagt acgaggcggc cgttctccgg ctccgggacg tgggcgtgcg
    19021 ccgcttcacg acggaccagc tgatcctcga cggcgtcgac tggacggtcc ggccgggtga
    19081 gcactgggcg ctgctggggg ccaacggcgc cgggaagacc acgctgctgc ggctgctcgg
    19141 cgcgctcatg caccccacca cgggcaccgt cgaggtgctc ggcagccggc tcggccgggt
    19201 ggacgtgcgg gagctgcggg cccgcatcgg ccacgtgaac tccgcgcagc gggtgccgca
    19261 ggacctcacc gcccacgcgg tcgtgctcac cggccacagc ggcaccgtgc agcccctgtg
    19321 gcggacgtat gacgacgagg tccgcctgcg ggcccgcgac ctgctgaccg agctgggcgt
    19381 caaggagctg gccgaccggc cgtacggggt ctgctcgggc gggcagcgcg cgcgggtcct
    19441 gatcgccagg gcgttgatgg ccgatccggc cctgctgctc ctggacgagc cgttcaacgc
    19501 cctggacctg ccttcccgcg aggatctcgt ggaggccatg caccaactgg ccgaggggcg
    19561 gacgcagttg gccaccgtga cggtcaccca ccacctggag gagctgtccc cggcggtgag
    19621 ccacgccctg ctgctgcgcg agggccggat catgtcgcgg ggcgcggtgg acgaggtcct
    19681 gaccgactcc cggctgaccg cctgcttcgg ccgggacatc acggtggccc ggcgcgacgg
    19741 ccgctggtcg gcctattccg gccggcgcgt ttccgggaca tgacacgccc acgaaggtgt
    19801 cgttgcggtc ctggcgcggc cgaccggtag gccttgaccc cccttcgcgc cctggttagc
    19861 gtccccggca tgcggagatt ccggcagttc acgaagcgac gcgccatcga tctgatgcgc
    19921 gtcgccaccg cggtgtgttg ctgagcccca ccgcccgact gtcctcttcc tcccgcatcc
    19981 cgtgaaggcc gcgatgacct ctcgcacacg catgcccgga ttccggcgcc tttccgtcct
    20041 ggccgcactg gccctccccc tgaccctcgc ctcctgcgtg accccggcac agtccacgac
    20101 gggcggccgg gacctctcgc gggagcggat cccggccgcg gtcgaccccg gcacgacgct
    20161 cacggtcggg gcgcccgacc tcagggtcgc cctcgaactg tcgggccagg ccgaccggct
    20221 gcccttcaag gtgaagtggg ccaacatcag cggtggcccc cagtgctccg aggccttccg
    20281 ggccgacgcc ctcgacatct gctcggccgc ggacatcccg tcgatcaacg cgcactggac
    20341 cggcctcgac accaagctcg tggcggtgaa gttccgcacg gatcccgtcg cccaccccgt
    20401 ctacgaactg ggaaccgccc ccggctccgg catcaggacc ctcgcggacc tgcgcgggaa
    20461 gaagatcgcc tacagcccgg gacaggccca gggcgccctg gtgctgcgca tcctcgcgaa
    20521 ggccggactc acccagcagg acgtcgaact cgtcgaactc gccagcaccg gcgacgtgta
    20581 tccgacggcg ctgggcaacc gccaggtgga cgccgccccc atcgccgacg tcaacatcaa
    20641 gcgctacctc gcccattacg gcgaggaggg cggcgcgacg atcaggcacg gcctccggga
    20701 cgacccggca cacctgtggg cgctcaccga atccgtcgcc gacgcacaga agtcggccgc
    20761 cgtccgggaa ctggtgaggt tctgggcacg ggcgcagacc tggatcgacc agcacccccg
    20821 cgagtgggtc gcgggctact acgtgaagga ccagggactc gaccgcgagg acggcgcata
    20881 cctggtacgg cgagtcggtc acccggacct tccggcggac tggaccgacg ccatccgccg
    20941 gcagcagcag accatcgacc tgctggccga ggagcagaac cgcgaaccgt tcgacgcgga
    21001 ccagctcttc gaccgccgct acgaggcggt ggccgcacag gcactcgccg gtgaggggac
    21061 gccgtcatga gcgccacgac cttcgaccag caggcgcccc cggcggcgcc gcccgcaccg
    21121 gacgcggc
//
