LOCUS       NZ_CP115937            24584 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces goshikiensis strain CGMCC 4.1796 plasmid punmamed1,
            complete sequence.
ACCESSION   NZ_CP115937
VERSION     NZ_CP115937.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces goshikiensis
  ORGANISM  Streptomyces goshikiensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 510574)
  AUTHORS   Mo,P.
  TITLE     The genome sequence of Streptomyces sporoverrucosus CGMCC 4.1796T
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 510574)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JAN-2023) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 184.03x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027942015.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 07:01:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,266
            CDSs (total)                      :: 7,170
            Genes (coding)                    :: 7,009
            CDSs (with protein)               :: 7,009
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 55 of 162
            Pseudo Genes (incomplete)         :: 131 of 162
            Pseudo Genes (internal stop)      :: 14 of 162
            Pseudo Genes (multiple problems)  :: 36 of 162
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:49:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 418488
            Orig. end                         :: 443072
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP115937.1.
            Bacteria and source DNA available from Mo Ping.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24584
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24584
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24584
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14584](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14584
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(79..94)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.05"
                     /tool="antismash"
     gene            complement(422..919)
                     /db_xref="GeneID:91414042"
                     /locus_tag="PET44_RS34135"
                     /old_locus_tag="PET44_34135"
     CDS             complement(422..919)
                     /codon_start=1
                     /db_xref="GeneID:91414042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740893.1"
                     /locus_tag="PET44_RS34135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34135"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_008740893.1"
                     /transl_table=11
                     /translation="MTFTSAAKPVLVRAAEAETLQDGATSLITLLADANATGGALTANR
                     ATLHKGSPGAPAHFHTRATEMFYVLGGSMRILLDDQVLTLGQGDFLTVPPTVPHAFAPA
                     PDSEAEMLVVFTPGMDRFDYYRLLERVYQGEASVQDIRDSSEQFDNHYFESPVWQRELA
                     RR"
     misc_feature    910..924
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            1164..1667
                     /db_xref="GeneID:91414043"
                     /locus_tag="PET44_RS34140"
                     /old_locus_tag="PET44_34140"
     CDS             1164..1667
                     /codon_start=1
                     /db_xref="GeneID:91414043"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566596.1"
                     /locus_tag="PET44_RS34140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34140"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_271245366.1"
                     /transl_table=11
                     /translation="MRTHHKTAIALAAALLTAVAPAVAQAAPAAGRGAAPSACRPANHT
                     AKITSAPASAGHHHYRVTLTAPRGYDPCALAGSPTDVRFSDHGSHTPVTAGRYGDQSAV
                     VTFGPGRPVHFDIQVPGDARQVRADEASFTLRGPDGPIPGASFAEGALMVAPGTLVGPV
                     EQGA"
     misc_feature    1730..1745
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.21"
                     /tool="antismash"
     misc_feature    1943..1958
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            1973..2710
                     /db_xref="GeneID:91414044"
                     /locus_tag="PET44_RS34145"
                     /old_locus_tag="PET44_34145"
     CDS             1973..2710
                     /codon_start=1
                     /db_xref="GeneID:91414044"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PET44_RS34145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PET44_34145"
                     /product="hypothetical protein"
                     /protein_id="WP_271245367.1"
                     /transl_table=11
                     /translation="MRSTSRRGVTTAAGVALAGVTLAMLPGSAQADDSWTSTVRIAKYT
                     AYLASQSAQGDTQAEETAQGFGALSKADKARFLDLIEDHAVMRKVFDPAEAPSALVGSS
                     QQVLAGGDVVVQHESLSGVDEASPHSSVALRASGYRDMWASYSITDRVMGVKVSRVTVR
                     TNYQVKGKDTTKVYPGSATHSLSVPGCSFSHSPVKEWISSAPADNAQSETIWSASCWGS
                     EWDKRERVWADYRGFVGGYLKDE"
     gene            complement(2745..>2951)
                     /db_xref="GeneID:91414045"
                     /locus_tag="PET44_RS34150"
                     /old_locus_tag="PET44_34150"
                     /pseudo=""
     CDS             complement(2745..>2951)
                     /codon_start=1
                     /db_xref="GeneID:91414045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131221.1"
                     /locus_tag="PET44_RS34150"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34150"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="PPGAPHTFANPGDRPAVMLSTFTPDLYLQYFRELRDGLGDGRRTL
                     TPQAAIDTMSRYATGAAAGLIRE"
     gene            2973..>3068
                     /db_xref="GeneID:91414046"
                     /locus_tag="PET44_RS34155"
                     /old_locus_tag="PET44_34155"
                     /pseudo=""
     CDS             2973..>3068
                     /codon_start=1
                     /db_xref="GeneID:91414046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670311.1"
                     /locus_tag="PET44_RS34155"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34155"
                     /product="LysR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSQPPLSRAIKGLEAEAGAPPFARSPAGATLT"
     gene            complement(3123..4082)
                     /db_xref="GeneID:91414047"
                     /locus_tag="PET44_RS34160"
                     /old_locus_tag="PET44_34160"
     CDS             complement(3123..4082)
                     /codon_start=1
                     /db_xref="GeneID:91414047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740889.1"
                     /locus_tag="PET44_RS34160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34160"
                     /product="phospholipase"
                     /protein_id="WP_271245368.1"
                     /transl_table=11
                     /translation="MRALLALMAALCAVIGTTALTTTPAAAADQRHPIYAIAHRVDTLA
                     GVDAALKHGANSIEIDVCAWWNPNEWRAYHDCSSAGDNRLGPSFDGMIDRILSNANAGR
                     RLSLVWLDIKDPNYCGERENRGCSVAGLRDKAQRLTAAGIQVLYGFYEYHGGNTPDVGG
                     RGWQSLEGRLGSLEGITSTGTRDQVQGAFNRSGSGFPAGRRAMDYGDSDITKGFGNCTE
                     PTYNTCAELKKGAGDRDAGRLAATLSWTTTYNDPWYVDKLLGDGRVDGIIAGYGAFTGV
                     REYDDSWQCANSIGLIRDWVNRHGGTHRMAGPGDRLFH"
     misc_feature    4110..4123
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.85"
                     /tool="antismash"
     misc_feature    complement(4149..4162)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            4487..4936
                     /db_xref="GeneID:91414048"
                     /locus_tag="PET44_RS34165"
                     /old_locus_tag="PET44_34165"
     CDS             4487..4936
                     /codon_start=1
                     /db_xref="GeneID:91414048"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PET44_RS34165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PET44_34165"
                     /product="hypothetical protein"
                     /protein_id="WP_271245369.1"
                     /transl_table=11
                     /translation="MREDSVVVAEFGALENSGGRPVRFAVLRGAGPEGTWLVEITPYLL
                     GTAGAEDLRNFARGILDTLSAGAGESDFFTLYKDTRNQVQAVIGFDEGLPYLIVDAYTE
                     FAGNRTGTSPMDEPVYAHMEAVSPSRADPASLESGARALLGALGV"
     gene            5148..6734
                     /db_xref="GeneID:91414049"
                     /locus_tag="PET44_RS34170"
                     /old_locus_tag="PET44_34170"
     CDS             5148..6734
                     /codon_start=1
                     /db_xref="GeneID:91414049"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PET44_RS34170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PET44_34170"
                     /product="hypothetical protein"
                     /protein_id="WP_271245370.1"
                     /transl_table=11
                     /translation="MAALSYEILTDPVPLQTSGSDDAQTSVAGTVYIVVSNPTTHWVPW
                     YQIEVVLPCGKEAGDLTDRPDMIKTGIEPYAVRFGDVPKDEWDAGTRTFTVSAALGGLF
                     TPGDSMVLSLDGFPVSDKEGLVRLTVNEISGGDPGDGVRTHPLTLSLLKRAPKAPRNFR
                     PEEALVGGGENVVLVWDGPDTLTYTIEGPDGLSVPVPQRTGPDWRWSPGPDDAPLRDAT
                     YTLVATSPDGRQPGYFLTTTVAVRRPEFEAVTATQGLFAPRIEGTTDKGVIVLTEDGVE
                     VLAADGEPGLVSAGKAEVEGVTTRWVRGRDAAAGWIEFPAAGLNVFRGEGDRKWGTVAA
                     DKADLNGINTAWVQGRDAAAGWIEFPAAGVNVFRGEGDRQWGTVAADKADLNDLLADRA
                     RVKDRLTLDGGLTVTDVLETQSGPSRLIVHGRLDAEGELSVNGELRASQSAEIAGAVVA
                     SDLTVRGKLRTNHEQFKLIVEGESLFREQANANGGLAVRNEHAGWLVHAKGEQVSIQGD
                     LRVHGAFRSDS"
     gene            6863..7000
                     /db_xref="GeneID:91414050"
                     /locus_tag="PET44_RS34175"
                     /old_locus_tag="PET44_34175"
     CDS             6863..7000
                     /codon_start=1
                     /db_xref="GeneID:91414050"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PET44_RS34175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PET44_34175"
                     /product="hypothetical protein"
                     /protein_id="WP_158074271.1"
                     /transl_table=11
                     /translation="MPQLEIEFPAFAENWLEVESVPQIGRDAAEERAWVPAYWAAPAAA
                     "
     gene            7080..8648
                     /db_xref="GeneID:91414051"
                     /locus_tag="PET44_RS34180"
                     /old_locus_tag="PET44_34180"
     CDS             7080..8648
                     /codon_start=1
                     /db_xref="GeneID:91414051"
                     /inference="COORDINATES: protein motif:HMM:TIGR04267.2"
                     /locus_tag="PET44_RS34180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34180"
                     /product="HEXXH motif-containing putative peptide
                     modification protein"
                     /protein_id="WP_037792652.1"
                     /transl_table=11
                     /translation="MSVAAINNNSPESLECPESPEFLERPESQAVRRADRMLVDDRRFG
                     DSRSIEERNVARFSIGAELLAEHDPGHGPVLRRISRADREQLLPLLGDPVLRNAFEDDL
                     VKLENGVRSGFSFGALASRIPDEPAGLGPCERMATPHVRPWADHGSAWVWTEMFPADRV
                     PGELATRLRQLYDGSIEGGPSADPVVPGPEMCRALGRGARLLTALLPRVGPSVLGHVSV
                     VGFTRGESADGPLQSLSGGDPLPSAILMAPERLADPWTVAETLLHESVHLKLFDALRAG
                     ALLTDPERSVPIPWRQTPWRLIRVLVALHFYVHLLVFQEAVRNAAPELRAEFGRPPVGE
                     VVDEVTPGTEAARNGTFGTGLERVRYLAGYIRELPPGTLTPAGRQLMRWLGEVTAVLDP
                     EPPAAPEPPAAPGPAATPVTAPAAPAAPAATRDAGPEEAVPHRTAGILARPMPAHGELL
                     LADTGTCTLHWLNARSWLVYSLCDGRDVPSVQAEYARRTGTDAPAAASHVTACLEELRN
                     SGLLS"
     gene            8765..8947
                     /db_xref="GeneID:91414052"
                     /locus_tag="PET44_RS34185"
                     /old_locus_tag="PET44_34185"
     CDS             8765..8947
                     /codon_start=1
                     /db_xref="GeneID:91414052"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="PET44_RS34185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34185"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_037792650.1"
                     /transl_table=11
                     /translation="MTAVLIEPIVRDLVMDDFDLDVRIAVSADFETAEAGFSNWYSCKS
                     TCVRECLGLSINGCN"
     CDS_motif       8765..8863
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAVLIEPIVRDLVMDDFDLDVRIAVSADFETA"
                     /locus_tag="PET44_RS34185_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8864..8947
                     /prepeptide="core"
                     /locus_tag="PET44_RS34185_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="2.70"
                     /molecular_weight="2852.2"
                     /monoisotopic_mass="2850.3"
                     /core_sequence="EAGFSNWYSCKSTCVRECLGLSINGCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAVLIEPIVRDLVMDDFDLDVRIAVSADFETA"
                     /leader_location="[8764:8863](+)"
                     /alternative_weights="2870.2"
     misc_feature    complement(9008..9020)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            9027..10004
                     /db_xref="GeneID:91414053"
                     /locus_tag="PET44_RS34190"
                     /old_locus_tag="PET44_34190"
     CDS             9027..10004
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91414053"
                     /inference="COORDINATES: protein motif:HMM:NF012888.4"
                     /locus_tag="PET44_RS34190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34190"
                     /product="sulfotransferase domain-containing protein"
                     /protein_id="WP_271245371.1"
                     /transl_table=11
                     /translation="MSAERVLVISPRKSGTHLVQELLVHLGYRIYGEPVPPPEGRPDFS
                     IRERLAMAERYLDPGEFRALDPRRDREAFLRTTDQVWLQLAWAWQTRMAVAPLTHVEAV
                     APAAGFGPKMSPDIWTAPFSQTPPGIAWIFHSADIWRMDASFLAEWVNTGSPKVILNYR
                     DPRDVLLSLVDFFSRNNGLRFRRFPETAIFGPVLESIQDPAAKIDYALSDPAMPLLGDY
                     ESAISFLHHPNVCTVSFEELVGPQGGGGHQTQRDAVRRVAAWLDQDADADAVAEELFTP
                     RSFTLNKGRAGRWREAFTPAHTERFEARFGHLLDTFGYDREVSR"
     gene            10001..11311
                     /db_xref="GeneID:91414054"
                     /locus_tag="PET44_RS34195"
                     /old_locus_tag="PET44_34195"
     CDS             10001..11311
                     /codon_start=1
                     /db_xref="GeneID:91414054"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="PET44_RS34195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34195"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_271245372.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-40, bitscore:
                     134.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISASLAGQARATAAMITSRLADPAHIEAAVAASTPDPNALGPRP
                     PSSLLAGDAGIALLLRHAGDAPHEEADRWRRAGHAALLRAVRDTREAPLTSAGIVTGSA
                     GLALAMAEFAATDHRYRPGLDGVHIGLADQTRRRLADGGPAGGPRFEDYDVLGGASGVL
                     GHLLTQAPDRTDPAPVHALIDDLVRFCTAESEGHEPRWVVPLEHYPLPPRTTREAHGFI
                     NLGMAHGIPGPLAALALAWKSGYRRPRMGEAIANTVAALSAAAVRDEFGVIWPGEIPVG
                     PDGRHTDEHHPARSAWCYGVPGIAVALLTAADALADRRLRNFAIEAIEADLRRVEATLD
                     RRSPSLCHGLAGLLSIAEVFARTTGSATARAFLPFLTEHLLSHCSADLPFGVQNREPPD
                     LKIDNPDFLCGAAGVAAALWTVSTPVSRGWQRALLIA"
     gene            11390..14584
                     /db_xref="GeneID:91414055"
                     /locus_tag="PET44_RS34200"
                     /old_locus_tag="PET44_34200"
     CDS             11390..14584
                     /codon_start=1
                     /db_xref="GeneID:91414055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="PET44_RS34200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34200"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_271245373.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.9e-159,
                     bitscore: 525.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-11,
                     bitscore: 39.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.6e-35, bitscore:
                     116.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLYTPAGYFLLRTPTLPFTPYAQALDGTGAAGRDRIREVAGQPL
                     VRQALRVASDSLAEQLRKDARDDRTDASLLRYVSRMSSRPTPYGLFAQVAAGEFGPRTS
                     LTRTGARPAATRTRADMGWLEQLVQQIEDDRDVRPGLTVVLNPLLQRSHDRLTLPVSHS
                     LRPTDQRVSSVRITRAVETVLDRAATRPTWAELTARAARDFPAVPAARIDALLDRLWDL
                     RMLTSDLRPPMTHPLPETAVLDRLAGLAGAERYRGALGRTRDLAARADAAPPEHAERLL
                     AELQTYQRTLVPGHTESPLQLDARAALATDTTAAAAATVTDPAATLSAAVADAAADAAD
                     VLLRLGHHTRDTALAAYHEHFLDRYGSGAEIPVLELLNPETGLGAPDGYHFPARELPLE
                     LGPRPRPATGRSALTALAAAALHQGATEVELTDAFLAGLPSANGGGAGPRPRPGLDVLG
                     QLMAESRQDLDTGRWRFVLTTGAVRDGGRIGARFFDLLGEDFGRRMKRYAEAEEARCPG
                     VLFAELNYRPLHSRGGNIAIHPSVRSHEICVNTEPTAGVGQIGLDDVLVGATSERLYLR
                     SAAHDQELKVTQSHLFNWSTAPNVCRFLLEVSQDGWAALAEFEWGDLLEAADFLPRVTR
                     GRVVLKPARWRFGPGAPGFPAGLASGTPEAERFFEIFQKWRRDWHVPRWVNLAMLDNRL
                     LLDLDSPVCVAEIQRELRSTAPHKGGNLIMEEALFDPLRPQWLRDGAGRSYTAEIAVPL
                     LARNTATGAAVPVAPATAIAAGRTAARRPALAKHQLPGGDWSHLKLYAAASRHEDLLTG
                     EVPRLVHGLREEGLIDRWFFIRYADPHPHLRIRVRRRPGAAPHAAMNRLVDWAGDLVGH
                     GPARDAALISYDRETERYGGPVALEALEAVFEAGSDMTTTVLALVRDRPGMDLDVVGAL
                     ALHRLYEAWGHQDGAPADTAPHHTVEARDREAFRAVRTTLCDLVAPWDARPDARARQWA
                     PDLDRLLAIQDQAVRQAGDLVRRLARAGELTGTEQDVLGSLAHMQSNRLLGIDRTRELR
                     SHSFRALALRAVRGRP"
     aSDomain        11819..12085
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PET44_RS34200_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.70E-13"
                     /identifier="RREFam001.1"
                     /label="PET44_RS34200"
                     /locus_tag="PET44_RS34200"
                     /protein_end="232"
                     /protein_start="143"
                     /score="39.8"
                     /tool="antismash"
                     /translation="VLNPLLQRSHDRLTLPVSHSLRPTDQRVSSVRITRAVETVLDRAA
                     TRPTWAELTARAARDFPAVPAARIDALLDRLWDLRMLTSDLRPP"
     gene            14581..16350
                     /db_xref="GeneID:91414056"
                     /locus_tag="PET44_RS34205"
                     /old_locus_tag="PET44_34205"
     CDS             14581..16350
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91414056"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="PET44_RS34205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34205"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_008740882.1"
                     /transl_table=11
                     /translation="MTGQWRRVLALLWSISPRQILAVTAASLATALLPAAQVFLTALTV
                     QSVADALTSPAAADRGALRAGACLAALLVAGHLLGVLHANQEALLRSRLPDVLTLRIMA
                     KAGRLTLGQFEEPDTYDNLQRATREAAFRPLQVFTGMLTVVSAALSFLAVATVLLRESI
                     AMAAAICLAPVPAALAGLWFSRRTHAAHHAQAEGRRTLTYLEHLLTNDRTYKETRLFNL
                     VPLLLDRSRRLTDDFHATNRRIENGQARWTALLGLLSTGTTAAAVLLAVRSALHTGQVG
                     ALAGYVAGVAVIQAAVSALFTSGVQLYENGLFLRHLFGFLDMPEPAVREGTLALPPVLS
                     KGIEFREVTFTYPGQREPVLDGVSFTVPAGARAALVGSNGAGKSTLIKLLTRFYEPTGG
                     TILIDGRPLSDYSLQGLREGIGAIFQDYQEYEAPVRENIGFGKPALLDDDGRIREAAHR
                     VGALAFLDTLPEGIDTRLGRWFPGGRQLSGGQWQKVALARALVGEAPVLILDEPTAAID
                     AAAEADILDVLRTVGTGATSLLVAHRFSAVRTADHIVVLDGGRVLEQGSHEQLMESGGR
                     YASLFGLQAAGYR"
     gene            complement(16394..17080)
                     /db_xref="GeneID:91414057"
                     /locus_tag="PET44_RS34210"
                     /old_locus_tag="PET44_34210"
     CDS             complement(16394..17080)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91414057"
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523488.1"
                     /locus_tag="PET44_RS34210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34210"
                     /product="response regulator transcription factor"
                     /protein_id="WP_008740881.1"
                     /transl_table=11
                     /translation="MTTYASVSHSPLHVAVVERNPLLRAGICAALTAAAGIEVVMDTGS
                     APGLGALVGAAAPDVILLDLDLPGSAALEVCRELMAGTGRRRAVLGMTGRGADAALVRS
                     ALLAGVRGCLAKDAGGPEVVGAVHMVARGLMVAGSPMDQVLSGLLTTGGRTAERQVLPE
                     LTRREREILDLVARGFDNRCIARTLTLADKTVRNHVSAVLGKIGVSSRGQAIVLAREAG
                     LGTSAR"
     gene            17173..20550
                     /db_xref="GeneID:91414058"
                     /locus_tag="PET44_RS34215"
                     /old_locus_tag="PET44_34215"
     CDS             17173..20550
                     /codon_start=1
                     /db_xref="GeneID:91414058"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="PET44_RS34215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34215"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_271245374.1"
                     /transl_table=11
                     /translation="MRSDRGAMFEYRILGPLDVRRAGRAVPVTAPKERDLITLLLLRAD
                     RTVPAEDLIDGLWGTTPPATARTTLQNYIKRLRRILQQPGTGHPETLVTRPGGYLLRLE
                     DAFLDLREFDGLVRAAAEATARGDDTTAAARLDAALSHWRGEALSGSRSQHLRQLEAPR
                     LEESRTVAFEQRVEAGLRLGMHAELIAGLRVEAARHPLRERLQAQLVLALYRSGRRGDA
                     LAAARQARDHLVRELGLEPGPHLARLHDRILADDPALMDPRPKAPAVDAAPGAPTPTAP
                     STPPGRPGPAGPDPAAAASLSVLPAQLPPSTMVFTGRAEALRRLDELLPTAGPQPSGAA
                     RIAQISGQGGVGKTALAVHWGHGRRNRFPDGQLYVNLRGHGGQRPLRPVDALGGFLEAL
                     GVPAREVPVSEDRCAARFRSLCAGRRLLVILDDASSEEQVRPLLPGSADCMVIVTSRRT
                     LAGLVARDGALPVPLPVLEPSEAERLLINILGAGRVSREPGAAAALTAACARLPLAVGI
                     SAADLALHPERTLAEQVERLVAEDRLSALELPGDSHSALRTVFAMSYATLDPDAARMFG
                     LLGTMPGADITVRAAAALAGVTRERSQALLDDLTRSHLLDEGAVGRYAFHDLLRAYARE
                     RVLDEQPEDVRSAATDRLYAWYLANVDKAAKVIQPQMLRLGTYTDGADLSFATPEDAAG
                     WLDSERANVVAMVQRAAEHGPRAAAWGLADAFRPYLMHSSYTAEWLAVGEAGLAAAEAD
                     GNAVGQAAGHRILSSAYLVLGRYDDCVRHDLAAVELYHGQGHTSGEAAAYNSLSLAAWY
                     GGRLDDAVEYGNRGLAIARTLEDKVPELIISTNVCGILHEAGMLREAEEHFEGMIGGQA
                     VDQTSTTESHTFTNFAALLHDRGLPERAAELLAKAEAIRRRAGQAPSSLSYTLYWKAVM
                     ALQAGDRASALEHVEEGFSSAGGDIRAQAYLYVARGMLAERTGGHETALRSFQQARDLA
                     EQCASRKPELEALTGMARCNLRAGRVETARSFAEELLQDATASGYRLFHGYALTLLAEI
                     ACEEGDPAEAQRRAGEAAAVQEANGHPRGRAEALIALARALRAAGDTEGARARVHQAAH
                     LWSGFAPRRAASILSLAD"
     gene            complement(20576..21037)
                     /db_xref="GeneID:91414059"
                     /locus_tag="PET44_RS34220"
                     /old_locus_tag="PET44_34220"
     CDS             complement(20576..21037)
                     /codon_start=1
                     /db_xref="GeneID:91414059"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="PET44_RS34220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PET44_34220"
                     /product="hypothetical protein"
                     /protein_id="WP_100582267.1"
                     /transl_table=11
                     /translation="MSERDNAPAVETSLWSAVTLLDERGPAAARAAVEEVLSALPGRRG
                     RDWTAPQEARIRALVKGMDALRTLDRAPEGWWGRRRARRARRRLAVLMRVAGPKLVDEA
                     ALRCWKSARVLEVLKAFAAGRRDRAEVAEVLDRLRVVQRATYLDLGQAA"
     gene            complement(21220..21933)
                     /db_xref="GeneID:91414060"
                     /locus_tag="PET44_RS34225"
                     /old_locus_tag="PET44_34225"
     CDS             complement(21220..21933)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91414060"
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740878.1"
                     /locus_tag="PET44_RS34225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34225"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190032549.1"
                     /transl_table=11
                     /translation="MAKDVVPEERRRRRRPTRRGTVLSERLIVETALRMVREHGSAGLS
                     ARRLGAALGADPSTLYRYFDGMDGLTLAIGEELIGRALAGWAPTGRWREDLRSLGLRIH
                     GAYLAHPQAALLTASRVTGRPREIAADEAILASLRGAGFGDVDAVRIYHAYIDQCLAFA
                     ALDAGALALSEKARDSDEERWESTYARLPAREYPNIAATAGLLAARMPHSAYPVALEML
                     LDAAERELGGGEPRG"
     gene            22036..23268
                     /db_xref="GeneID:91414061"
                     /locus_tag="PET44_RS34230"
                     /old_locus_tag="PET44_34230"
     CDS             22036..23268
                     /codon_start=1
                     /db_xref="GeneID:91414061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057045.1"
                     /locus_tag="PET44_RS34230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34230"
                     /product="saccharopine dehydrogenase C-terminal
                     domain-containing protein"
                     /protein_id="WP_271245375.1"
                     /transl_table=11
                     /translation="MRVLLVGAGGVGSAITKIAARRDFFDHFVVADYDLTRAEAAVAAL
                     GDEERRFSACRVDASDESAVTRLLTERGCDVLMNATDPRFVMPLFNAALAAGSHYLDMA
                     MSLSRPHPDHPHRACGVKLGDEQFERAAEWEKSGRLALVGMGVEPGLSDVFARYAADHL
                     FDEIEEIGIRDGANLTVEGHDFAPSFNIWTTIEECLNPPVVYERERGWFTTEPFSEPEV
                     FDFPEGIGPVECVNVEHEEVLLVPRWVGARRVTFKYGLGDDFIGKLKTLHALGLDSTDR
                     VAVRGEDGREVRVSPRDVVAACLPDPATLGDRMTGKTCAGTWVKGTKDGLPREVYLYHV
                     VDNQWSMREYGSQAVVWQTAVNPVVALELLATGVWSQPGVLGPEALPPTPFLDLLTVYG
                     SPWAIREHPTP"
     gene            complement(23219..23641)
                     /db_xref="GeneID:91414062"
                     /locus_tag="PET44_RS34235"
                     /old_locus_tag="PET44_34235"
                     /pseudo=""
     CDS             complement(23219..23641)
                     /codon_start=1
                     /db_xref="GeneID:91414062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016894700.1"
                     /locus_tag="PET44_RS34235"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="PET44_34235"
                     /product="gamma-glutamylcyclotransferase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSMAAPYLLFSYGTLQLEQVQLARFGRLLEGAPDALPGYTTSVVR
                     ITDPDVIAASGSDLHPVVVLSGD"
ORIGIN
        1 tggtggctcc ggtcctcgcg gcgaagggcc tgcgcgagcg ctggacgggc gtggtggacc
       61 agctcacctt cgcggacctg atcgcctccg gcgcctacga ccggcacgtc cggcagatgc
      121 gccagcgcta ccgcgaccgc cggggccgcc tggtcgccgc gctcgccgag cacgcgccgc
      181 acatcgaggt caccgggatc gcggcggggc tgcacgcggt gctgcgcctg cccccgggca
      241 ccgagaccgc ggccgtggac gccgcttccc tgctcggcct cggactcgac gggctcgccg
      301 gcttccggca tcccgacacc gccgaggccc tgttcgacgg gctggtcgtc ggctacgcgg
      361 ccccgccgga ccacgcgtac gccgccgctc tggacgcgct ctgcacgatc ctgccccccg
      421 ttcagcgacg ggcgagttcc cgctgccaga ccgggctctc gaagtagtgg ttgtcgaact
      481 gctcggagct gtcacggatg tcctgcaccg aggcctcgcc ctggtacacg cgctccagca
      541 gccggtagta gtcgaaccgg tccatccccg gggtgaagac gacgagcatc tcggcctcgc
      601 tgtccggggc cggcgcgaag gcgtgcggca cggtcggcgg cacggtcagg aagtcgccct
      661 ggccgagcgt gaggacctgg tcgtcgagga ggatccgcat ggacccgccc agtacgtaga
      721 acatctcggt cgcccgggtg tggaagtgcg cgggagcgcc gggcgaaccc ttgtgcagcg
      781 tcgcccggtt ggcggtcagc gcaccgccgg tggcgttcgc gtcggcgagc agcgtgatca
      841 ggctggtcgc cccgtcctga agcgtctcgg cctcggcggc gcggacgagg acgggcttcg
      901 cggcgctggt gaacgtcatg ggcactcctt ggtttcagtg gttccgccga ccggtcactc
      961 ccggcgacac cactgaatct agtctccgga aagacccacg gaagggtgca ttgaaggccc
     1021 ggaatcatgg gtcaattcag gggcggtcag ggccgtgacg atctcgggac attctctgac
     1081 agcgcaccgg ggaacaggtc ataccgacca gggacccggc ggaccacacc cgcggggccg
     1141 acgtgcaagg caaggagtgc tccgtgcgca cccaccacaa gaccgccatc gccctcgccg
     1201 ccgcgctgct gaccgcggtg gccccggccg tcgcgcaggc cgccccggcg gcgggacgcg
     1261 gcgccgcccc ctcggcgtgc cgtccggcca accacaccgc gaagatcacc tcggcgccgg
     1321 ccagcgcggg gcaccaccac taccgcgtca ccctgaccgc gccgcgcggc tacgacccct
     1381 gcgcgctggc cggttcgccg accgacgtgc ggttctccga ccacggctcg cacaccccgg
     1441 tcaccgccgg ccgctacggc gaccagagcg ccgtggtcac cttcggcccc ggccgcccgg
     1501 tgcacttcga catccaggtc ccgggcgacg cccgtcaggt ccgcgcggac gaggcgtcct
     1561 tcacgctccg tggcccggac gggccgatcc cgggtgcctc cttcgccgag ggcgcgctga
     1621 tggtcgcccc cggcaccctc gtcggcccgg tggaacaagg cgcctgaccg cgaccgagcg
     1681 ggagaaatcg ggcttcgcgg ccgattattc ggattcgcca attccgtata ttgcgaagcc
     1741 tttgccgtgg cgttcgtctt aactcaggtc tacctcaaat cccggaagat cgattgacgc
     1801 gtcgcgtcct ccccgtgcag tctttgcgaa gcgcggcccg gcccagggga atgaaagagc
     1861 cggggcgcgc aacacggggg gaacggggga tttgcagggt gtacattcat gcccttttcc
     1921 ctttcctgct cgaacggctt cgagtggtat ggacctaagg ggaaagaacg ttatgcgctc
     1981 cacttccaga agaggtgtca ccacggccgc cggcgtcgct ctcgccggag tgaccctggc
     2041 catgctgccg ggctcggccc aggccgacga ctcctggacc tcgaccgtac ggatcgccaa
     2101 gtacacggcc tacctcgcgt cgcagtcggc ccagggggac acgcaggccg aggagaccgc
     2161 ccagggattc ggcgccctct cgaaagccga caaggcccgc ttcctcgacc tgatcgagga
     2221 ccacgcggtg atgcgcaagg tcttcgaccc ggccgaggcc ccgtccgcgc tcgtgggctc
     2281 gtcgcagcag gtgctggccg gcggcgacgt cgtggtgcag cacgagtccc tcagcggcgt
     2341 cgacgaggcc tcgccccaca gctccgtggc gctcagggcc tccggctacc gggacatgtg
     2401 ggcctcgtac tcgatcaccg acagggtcat gggtgtcaag gtctcgcggg tcacggtgcg
     2461 gaccaactac caggtgaagg gcaaggacac cacgaaggtg tacccgggca gtgcgaccca
     2521 ttccctttcc gtgccgggat gctctttctc ccacagcccg gtgaaggaat ggatttcctc
     2581 tgcgccggca gacaatgccc agagcgagac catttggtcg gcatcgtgct ggggcagcga
     2641 atgggacaag cgggagcggg tctgggccga ctaccgcggc ttcgtgggcg gttacctcaa
     2701 ggacgagtaa acggaaatgc cggtgaattc tccttcaggt gaattcactc tcggatgagg
     2761 ccggcggcgg ccccggtcgc gtagcggctc atggtgtcga tggcggcctg cggcgtcagc
     2821 gtccgccggc cgtcgccgag cccgtcccgc agctcccgga agtactgcag gtacaggtcc
     2881 ggggtgaagg tgctgagcat gacggcgggc cggtcgcccg ggttggcgaa ggtgtgcggg
     2941 gcgccgggcg gaaggccgcc gcccgactgc acatgagcca gccgccgctg agccgggcga
     3001 tcaaggggct ggaggccgag gccggggccc cgccgttcgc ccgctcaccc gccggcgcca
     3061 cgctgacgcg atgtcgtgcg ctcgcgcgga agcgcacgac atcgcggggg acaggcccgt
     3121 gcctagtgga acagacggtc cccggggccg gccatgcgat gcgtgccgcc gtggcggttc
     3181 acccagtcac ggatgaggcc gatcgagttg gcgcactgcc agctgtcgtc atactcgcgc
     3241 acccctgtga aggccccgta gcccgcgatg atgccgtcca cgcgcccgtc gcccagcagc
     3301 ttgtccacgt accacgggtc gttgtaggtg gtcgtccagg acagcgtggc cgcgagccgt
     3361 ccggcgtcac ggtccccggc gcccttcttc agctccgcac aggtgttgta ggtgggctcc
     3421 gtgcagttgc cgaacccctt ggtgatgtcg ctgtcgccgt agtccatcgc ccggcggccg
     3481 gccgggaacc cggaaccgga ccggttgaag gcaccctgga cctggtcgcg ggtaccggtc
     3541 gaggtgatcc cctccaggct gccgagccgg ccttccagac tctgccagcc ccggccgccc
     3601 acgtccgggg tgttgccgcc gtggtactcg tagaacccgt acagcacctg gatcccggcg
     3661 gccgtcagcc gctgcgcctt gtcgcgcagt ccggcgacgc tgcacccgcg gttctcccgc
     3721 tccccgcagt agttcgggtc cttgatgtcc agccagacca gcgacagccg gcgccccgcg
     3781 ttggcgttgg acagaatgcg gtcgatcatg ccgtcgaagc tggggcccag ccggttgtca
     3841 ccggccgagg aacagtcgtg gtaggcccgc cattcgttcg ggttccacca ggcacagacg
     3901 tctatctcga tgctgttggc gccgtgcttg agggccgcgt ccacaccggc cagggtgtcg
     3961 acgcggtgcg cgatggcgta gatcgggtga cgctgatcgg ccgctgccgc cggggtcgtc
     4021 gtgagcgcgg tggtaccgat gaccgcgcac agggccgcca tcagcgccaa gagagcccgc
     4081 acccgtgaac cggcagcacg cctgaggtga gtggtcaaga aaactccccg tcatgtcggt
     4141 gtcctgatcg gacatttgtt ctggtcccgc acatgctggc acgcgataaa tgcatgatga
     4201 atggacctgg tggaaggcag ccacggagtg gcgggaaccc gcctccggcc gttcttgacc
     4261 agcccctcgg cccggatcgc gtacgccatg ctcgacaact cctcgtcagt tcctcgttct
     4321 cgacgcccca gaccctgccg cccctccctg acaccccccg gccaccccgc tgacagcccc
     4381 cgccgaaccc tgtcagcccc tgtcagcgcc ggggcccggc ccgcccaggt accgtcgtcc
     4441 cgtgaacggg gacatgggca ggggagtgac cgcggaagtg cgcgccatgc gtgaagacag
     4501 cgtggtcgtg gcggagttcg gcgcgctgga gaacagcggg ggacgcccgg tccggttcgc
     4561 ggtcctgcgc ggcgccgggc cggagggcac ctggctggtg gagatcaccc cgtacctgct
     4621 cggtacggcg ggagccgagg acctgcggaa cttcgcccgc ggcatcctcg acaccctctc
     4681 ggccggggcc ggcgaatccg acttcttcac cctgtacaag gacacccgca accaggtgca
     4741 ggcggtcatc ggcttcgacg aggggctgcc ctacctcatc gtcgacgcct ataccgaatt
     4801 cgccgggaac cgcaccggta cctcgccgat ggacgagcct gtgtacgccc acatggaggc
     4861 cgtcagcccc tcccgggccg accccgcgtc cctcgaatcc ggcgcccgcg ccctgctggg
     4921 cgcgctcggg gtctgacgag cgggagccgc ccttcgaacg gggggcgatt tcggatcacc
     4981 tgcgtgccgt gccggattcg gtcctgttct ggccattgcc cacctgtttc gcgccggtca
     5041 tggcgtatcg gggttttcgc ggggtccgga tggagagcgc tccgtgcggc ggggaccgcg
     5101 tccgtggggg gcgagcgccc gccagtcgaa caagggggtt ttgagcgatg gctgctctga
     5161 gctacgagat ccttaccgac ccggtaccgc tccagacgtc cgggtcggac gacgcccaga
     5221 cgtccgtggc gggcacggtg tacatcgtcg tctccaatcc gacgacacac tgggtgccct
     5281 ggtaccagat cgaggtggtc ctgccctgcg ggaaggaggc cggggacctt acggaccggc
     5341 cggacatgat caagaccggg atcgagccct acgcggtccg gttcggggac gtaccgaagg
     5401 acgagtggga cgcggggacc cgcaccttca cggtctccgc cgccctcggc gggctgttca
     5461 ccccgggtga ttcgatggtc ctgtcgctgg acgggttccc cgtctccgac aaggagggcc
     5521 tggtccgcct cacggtgaac gagatctcgg gcggggaccc gggggacggg gtgcgcaccc
     5581 accccctgac cctgagcctg ctgaagcgcg cgccgaaggc accgcgcaac ttccgcccgg
     5641 aggaagccct ggtgggcggg ggcgagaacg tggtcctggt gtgggacggc cccgacaccc
     5701 tgacctacac gatcgagggc ccggacggcc tctccgtacc cgtcccgcaa cgcaccgggc
     5761 ccgactggcg gtggtcgccc ggcccggacg acgcacccct gcgggacgcc acctacaccc
     5821 tggtggccac ctccccggac ggacggcagc ccggctactt cctcacgacc accgtcgccg
     5881 tgcgcaggcc cgagttcgag gccgtcaccg ccacccaggg cctcttcgcg ccccggatcg
     5941 agggcaccac ggacaagggc gtgatcgtcc tgaccgagga cggcgtcgag gtcctcgccg
     6001 ccgacggcga acccggcctg gtctcggccg ggaaggccga ggtggagggc gtgaccacac
     6061 ggtgggtgcg gggccgcgac gccgccgccg gctggatcga gttccccgcc gccgggctga
     6121 acgtcttccg gggtgagggc gaccgtaagt gggggaccgt cgccgccgac aaggccgacc
     6181 tcaacggcat caacaccgcc tgggtgcagg gccgggacgc cgccgccggg tggatcgagt
     6241 tcccggccgc cggggtcaac gtgttccggg gcgaggggga ccggcagtgg gggaccgtgg
     6301 cggccgacaa ggccgacctc aacgacctcc tcgccgaccg ggcacgggtc aaggaccggc
     6361 tcaccctgga cggcgggttg acggtcacgg acgtactgga gacacagagc gggccgtccc
     6421 ggctgatcgt ccacggccgg ctggacgccg agggcgagct gagcgtcaac ggcgagctgc
     6481 gggcctcgca gagcgccgag atcgccggcg cggtcgtggc gagcgacctg acggtccggg
     6541 gcaagctgcg gaccaaccac gagcagttca agctcatcgt ggagggcgag tcgctcttcc
     6601 gcgagcaggc gaacgccaac ggcgggctcg cggtgcgcaa cgagcacgcg ggatggctgg
     6661 tgcacgccaa gggagagcag gtctcgatcc agggagacct gcgggtccac ggcgcgttcc
     6721 gctcggactc ctgaccccgg ggggaggccg caccgcccgc cgggtcggga caattccggg
     6781 acggccgccc catgattgcg ggacggtatt ccggtcattc tggcggggtt cgcccaccag
     6841 ggcgacggaa aaggagtgac cgatgccgca gctggagatc gaattccctg ccttcgccga
     6901 gaactggctt gaggtggaaa gcgtcccgca gatcgggcgg gacgccgccg aggagcgtgc
     6961 gtgggttccc gcgtactggg cagcgcccgc cgctgcctga cgcagcaggc cgggggtggc
     7021 atcgatgcga tgccaccccc ggccgtcctt tttctcacct ccgcacgaac ggtggcccga
     7081 tgtctgtcgc tgcaatcaac aacaattccc cggagtccct ggaatgcccg gaatccccgg
     7141 agttcctgga acggccggaa tcccaggcgg tccggcgcgc ggaccgcatg ctggtggatg
     7201 accgcaggtt cggcgattcc cgctccatcg aggagcggaa cgtcgcccgg ttctccatcg
     7261 gcgcggaact cctcgcggag cacgatccgg gccacgggcc ggtgctccgc cgcatctccc
     7321 gggccgaccg ggagcaactg ctgccgctcc tcggcgaccc cgtcctgcgc aacgccttcg
     7381 aggacgacct ggtcaagctg gagaacgggg tcaggtccgg cttcagcttc ggggcgctgg
     7441 cgtcgcggat ccccgacgaa ccggcgggac tcggcccgtg cgagcgcatg gcgaccccgc
     7501 acgtacggcc gtgggcggac cacggctccg cctgggtctg gaccgagatg ttcccggccg
     7561 accgcgttcc gggggagctg gccacccggc tgcggcagtt gtacgacggc agcatcgagg
     7621 gcggcccctc cgcggacccc gtcgtgcccg gccccgagat gtgccgggcg ctgggccgag
     7681 gcgcgcggct gctcacggcg ctcctgccgc gggtcgggcc cagcgtgctc ggccacgtgt
     7741 cggtggtcgg cttcacccgg ggggagtcgg cggacggccc gctgcagtcc ctgtccggcg
     7801 gcgacccgct gccctcggcg atcctgatgg ccccggagcg gctggcggat ccctggacgg
     7861 tcgcggagac gctgctgcac gagagcgtgc acctcaagct gttcgacgcg ctgcgggcgg
     7921 gcgccctgct cacggatccc gagcgctccg tgccgatccc gtggcggcag acgccgtggc
     7981 gcctcatccg cgtcctggtg gcgctccact tctacgtgca cctgctggtc ttccaggagg
     8041 ccgtccgcaa cgccgccccg gaactgcggg cggagttcgg ccggccgccc gtgggtgagg
     8101 tcgtcgacga ggtgaccccg ggcaccgagg ccgcgcggaa cggcaccttc ggtaccggcc
     8161 tggagcgggt ccgctacctc gccggctaca tacgcgagct gcctccgggc accctcaccc
     8221 ccgcgggccg gcagctgatg cgctggctgg gcgaggtcac ggcggtgctc gaccccgagc
     8281 cgcccgccgc ccccgagccg cccgccgccc ccggtcccgc cgcgacaccc gtcacggctc
     8341 ccgccgcccc ggccgcgcct gcggcaacgc gcgacgccgg cccggaggaa gccgtaccgc
     8401 accgcaccgc cggcatcttg gcccgtccga tgcccgccca cggtgaactg ctcctcgccg
     8461 acaccgggac gtgcaccctg cactggctca acgcccgctc atggctcgtc tactcgctgt
     8521 gcgacgggcg cgatgtgccc tccgtacagg cggagtacgc ccgccggacc ggtaccgacg
     8581 cgccggccgc cgcctcgcac gtcacggcct gcctcgaaga actgaggaat tccggactgc
     8641 tttcctgaga aatgtcccgc acgggggtcg ggacatttca gggacagcgg catcaggaat
     8701 ccgggacacc agccgggtga agatatgact gtccgaatcg gacaccacca gaaggagaaa
     8761 tgaaatgact gctgtcctca tcgagccgat cgtacgggat ctcgtcatgg acgacttcga
     8821 cctcgacgtc cgcatcgccg tcagtgcgga cttcgagacc gccgaggccg gcttcagcaa
     8881 ctggtactcc tgcaagagca cctgcgtccg ggaatgtctc ggcctttcca tcaacggttg
     8941 caactgatct cgcgggacaa gtgaattcgg gcggcctgcc ggttccgggc gggccgcccg
     9001 ttcgtctttg gaaagggcaa accgaagtgt cggcagagcg ggtcctcgtc atatctccca
     9061 ggaagtccgg aacccatctg gtccaggaac tcctggtcca cctcgggtac cggatctacg
     9121 gggagcccgt acccccgccc gagggccggc cggacttcag catccgcgag cggctcgcca
     9181 tggcggagcg gtacctcgac cccggggagt tccgggcgct cgacccccgc cgggaccggg
     9241 aggccttcct gcgcaccacc gaccaggtct ggctccagct ggcctgggcc tggcagacgc
     9301 ggatggcggt ggcaccgctg acccatgtgg aggccgtggc tcccgccgcc gggttcggcc
     9361 cgaagatgag cccggacatc tggacggccc cgttctcgca gaccccgccc ggcatcgcct
     9421 ggatcttcca ctccgccgac atctggcgga tggacgcgtc cttcctcgcc gagtgggtga
     9481 acaccggttc ccccaaggtg atcctgaact accgggaccc ccgcgacgtc ctgctctcgc
     9541 tggtcgactt cttctcgcgg aacaacggcc tgcggttccg gcggttcccg gagacggcga
     9601 tcttcggccc ggtcctggaa tccatccagg accccgcagc caagatcgac tacgcgctgt
     9661 ccgaccccgc gatgcccctc ctcggcgact acgagtcggc catcagcttc ctgcaccacc
     9721 ccaacgtgtg cacggtctcc ttcgaagaac tcgtcggccc ccagggcgga ggcggccacc
     9781 agacccagcg cgacgccgtc cgccgggtcg ccgcgtggct ggaccaggac gccgacgcgg
     9841 acgcggtggc ggaggaactc ttcacccccc gctccttcac cctgaacaag ggccgggccg
     9901 gccggtggcg cgaggcgttc accccggcgc acaccgaacg cttcgaagcc cgcttcggcc
     9961 acctgctgga caccttcggc tacgaccgcg aggtgtcccg gtgatctccg cgtccctcgc
    10021 cgggcaggcg cgcgccaccg cggccatgat cacctccagg ctcgcggacc ccgcccacat
    10081 cgaggcggcg gtggccgcct cgaccccaga ccccaacgcc ctggggccgc gcccgccgag
    10141 ctccctgctc gccggggacg ccgggatcgc gctgctgctc cgccacgccg gcgacgcgcc
    10201 gcacgaggag gcggaccggt ggcgccgcgc cggccacgcg gcgctgctcc gggcggtccg
    10261 cgacacgagg gaggcacccc tcaccagtgc cgggatcgtc accggatcgg ccggactggc
    10321 cctcgccatg gccgagttcg ccgcgaccga ccaccgctac cggcccgggc tggacggtgt
    10381 gcacatcgga cttgccgacc agacccgccg acggctcgcc gacggggggc cggcgggcgg
    10441 cccccggttc gaggactacg acgtgctcgg cggcgcctcg ggcgtactcg gccacctgct
    10501 gacccaggcg cccgaccgca cggaccccgc gcccgtccac gccctgatcg acgacctggt
    10561 ccgcttctgt acggcggaga gcgaaggaca cgaaccccgc tgggtcgtcc cgttggagca
    10621 ctacccgctg ccgccccgca ccacgcggga ggcccacggc ttcatcaacc tgggcatggc
    10681 ccacggcatc ccgggacccc tcgccgcgct cgccctcgcc tggaagtccg gctaccggcg
    10741 cccccgtatg ggcgaggcca tcgccaacac cgtcgcggcg ctctccgcgg ccgcggtccg
    10801 ggacgagttc ggcgtcatct ggcccggcga gatcccggtg ggacccgacg gccggcacac
    10861 cgacgagcac catcccgccc gctccgcctg gtgctacggc gttcccggca tcgccgtcgc
    10921 cctgctcacc gctgccgacg cgctcgccga ccggcggctg cgcaacttcg ccatcgaggc
    10981 gatcgaagcg gacctgcggc gcgtcgaggc gacgctggac cgccgctcgc cctcgctctg
    11041 ccacggcctc gccggactcc tctcgatcgc cgaggtgttc gcccgcacca ccggcagcgc
    11101 gacggcgcgg gcgttcctcc ccttcctcac cgagcacctc ctgtcccact gctcggcgga
    11161 cctgccgttc ggcgttcaga accgggaacc cccggatctg aagatcgaca acccggactt
    11221 cctgtgcggt gcggccggcg tggccgccgc cctgtggacc gtgtccaccc cggtctcccg
    11281 cggctggcag cgcgccctgc tgatcgcctg aagccggacc ggaccggacc ggttcggttc
    11341 ggtccgcgca ccccaccccc tctgaccccg cgtgagaacg agcgacccga tgaacctgta
    11401 cacgcccgcg ggatacttcc tcctgcgcac ccccaccctg cccttcaccc cgtacgcgca
    11461 ggccctcgac ggcacgggag cggcaggccg cgaccggatc agggaggtgg ccggccagcc
    11521 gctggtccgc caggccctgc gggtggccag cgacagcctc gcggagcagc tgcgcaagga
    11581 cgcccgggac gacaggacgg acgcgtccct gctgcgctac gtgtcccgga tgagctcccg
    11641 gcccacgccg tacggactgt tcgcccaggt cgccgcgggg gagttcgggc cgcggacgtc
    11701 cctcacgcgc accggtgcgc ggcccgcggc cacccggacc cgggcggaca tgggctggct
    11761 cgaacagctc gtccagcaga tcgaggacga ccgggacgtc cgccccggac tgacggtggt
    11821 cctcaacccg ttgctccagc gcagccacga ccgcctcacg cttccggtct cccacagcct
    11881 ccggccgacc gaccagcggg tcagcagcgt ccggatcacc cgggccgtcg aaaccgtcct
    11941 ggaccgcgcc gccacccggc ccacctgggc cgagctgacc gcccgcgccg cgcgggactt
    12001 ccccgccgtg ccggcggccc ggatcgacgc cctcctcgac cggctgtggg acctgcgcat
    12061 gctgacgagc gacctgcggc ccccgatgac ccacccgctg cccgaaacgg cggtgctcga
    12121 ccggctggcc gggctggccg gcgccgagcg gtaccgcggc gcgctggggc gcacccgcga
    12181 tctcgccgcc cgcgcggacg ccgcgccgcc cgaacacgcc gagcggctcc tcgcggaact
    12241 ccagacgtac cagcggaccc tggtgcccgg ccacacggag agcccgctcc aactcgacgc
    12301 ccgcgccgca ctcgccaccg acaccaccgc agccgctgcc gccaccgtca ccgaccccgc
    12361 cgccaccctc tccgccgcgg tggcggacgc cgccgcggac gccgccgacg tcctgctccg
    12421 cctgggccac cacacccggg acaccgccct cgccgcctac cacgagcact tcctcgaccg
    12481 gtacggaagc ggcgccgaga tccccgtact cgaactgctg aaccccgaga ccggcctcgg
    12541 cgcccccgac ggctaccact tcccggcccg cgaactcccg ctggagctcg gcccgaggcc
    12601 ccggcccgcc accgggcgca gcgcgctgac cgccctcgcc gcggccgccc tgcaccaggg
    12661 cgcgaccgag gtcgagctga ccgacgcgtt cctcgcgggc ctgccgtcgg cgaacggggg
    12721 cggcgccgga ccgcggcccc gccccggcct cgacgtcctc gggcagctca tggccgagag
    12781 ccggcaggac ctggacaccg gccggtggcg gttcgtcctg accaccgggg cggtacggga
    12841 cggcggccgg atcggcgccc ggttcttcga cctgctgggc gaggacttcg gccggcggat
    12901 gaagcggtac gccgaggccg aggaggcccg ctgtcccggc gtgctcttcg ccgagctcaa
    12961 ctaccgcccg ctgcactccc gcggcggcaa catcgccatc cacccgtcgg tgcgaagcca
    13021 cgagatctgc gtcaacaccg aacccaccgc gggcgtcggg cagatcggcc tggacgacgt
    13081 cctggtcggt gcgacgtcgg agcgcctcta cctccgctcc gccgcccacg accaggagct
    13141 gaaggtcacc cagtcccacc tcttcaactg gagcaccgca cccaacgtct gccggttcct
    13201 cctggaggtc tcccaggacg gctgggcggc gctcgccgag ttcgaatggg gcgacctgct
    13261 ggaggccgcc gacttcctgc cccgcgtcac ccgcggccgc gtcgtcctca aacccgcccg
    13321 ctggcggttc ggccccggcg caccgggctt cccggccggc ctggcgtccg gcacaccgga
    13381 ggcggaacgc ttcttcgaga tcttccagaa gtggcgccgc gactggcacg tcccccgctg
    13441 ggtcaacctg gccatgctgg acaaccggct gctcctcgac ctcgacagcc ccgtctgcgt
    13501 cgccgagatc cagcgggagc tgcgctccac cgcaccccac aagggcggga acctcatcat
    13561 ggaggaggcc ctcttcgacc ccctgcgccc ccagtggctc cgcgacgggg cgggccgctc
    13621 gtacaccgcc gagatcgcgg tgccgctgct cgcccggaac acggccaccg gcgccgcggt
    13681 gcccgtcgca ccggccacgg ccatcgccgc cggccgcacc gcggcgagga ggcccgcgct
    13741 cgccaaacac cagctcccgg gcggggactg gagccacctc aagctctacg ccgccgcctc
    13801 ccggcacgag gacctgctca ccggtgaggt cccccggctc gtccacggcc tccgcgagga
    13861 gggcctgatc gaccgctggt tcttcatccg ctacgccgac ccccacccgc acctgcggat
    13921 ccgggtgcgg cgccgccccg gggccgcacc ccacgcggcc atgaaccggc tggtcgactg
    13981 ggccggcgat ctcgtcggcc acggaccggc gcgcgatgcc gccctgatct cgtacgaccg
    14041 ggagaccgag cgctacggcg gaccggtggc cctcgaagcg ctggaggccg tcttcgaggc
    14101 gggcagtgac atgaccacga cggtactggc actagtgcgc gaccggcccg gcatggacct
    14161 cgacgtcgtc ggcgccctgg ccctgcaccg gctgtacgag gcgtggggac accaggacgg
    14221 cgccccggcc gacacggcac cgcaccatac ggtcgaggcc cgtgaccgcg aggccttccg
    14281 cgccgtacgc accacgctgt gcgacctcgt ggccccctgg gacgcccgcc ccgacgcccg
    14341 cgcccggcag tgggcccccg acctcgaccg cctcctcgcc atccaggacc aggccgtacg
    14401 gcaagccggc gacctggtac gacggctcgc acgggcgggg gagctgaccg gcaccgaaca
    14461 ggacgtcctc ggcagcctcg cccatatgca gagcaaccgg ctcctgggca tcgaccgcac
    14521 ccgggaactg cggagccaca gcttccgggc gctggcgctg cgcgccgtac ggggccggcc
    14581 gtgaccggcc agtggcgacg ggtcctcgca ctgctgtggt ccatcagccc ccggcagatc
    14641 ctcgcggtca ccgcggcgtc gctcgccacc gccctcctgc ccgccgcaca ggtgttcctc
    14701 accgccctca ccgtgcagtc cgtggccgat gccctgacct ccccggcggc cgccgaccgg
    14761 ggcgcgctgc gggccggggc ctgcctcgcc gcgctcctgg tggccgggca cctcctgggg
    14821 gtcctgcacg cgaaccagga ggcgctgctg cgcagccgcc tcccggacgt gctcaccctg
    14881 cggatcatgg cgaaggcggg gcggctgacg ctcggccagt tcgaggaacc ggacacctac
    14941 gacaacctcc agcgcgccac ccgcgaagcg gcgttccgcc cgctccaggt gttcaccggc
    15001 atgctcaccg tcgtctcggc cgccctctcc ttcctggcgg tcgcgaccgt cctgctgcgc
    15061 gagagcatcg ccatggcggc ggcgatctgc ctcgcccccg tccccgccgc cctggcaggt
    15121 ctgtggttca gccgccgcac ccacgcggcc caccacgccc aggccgaagg acgccgcacg
    15181 ctgacctacc tcgaacacct cctcaccaat gaccgcacct acaaggagac ccgcctcttc
    15241 aacctggtgc cgctgctcct cgaccggtca cggcggctca ccgacgactt ccacgccacc
    15301 aaccggcgga tagagaacgg ccaggcccgg tggaccgccc tgctgggact gctcagcacc
    15361 ggcaccaccg ccgccgccgt cctgctggcc gtgcggtccg cgctgcacac cgggcaggtc
    15421 ggtgcgctcg ccggatacgt cgcgggcgtc gccgtcatcc aggccgccgt gtccgccctg
    15481 ttcaccagcg gcgtccagct ctacgagaac gggctcttcc tgcggcacct gttcggcttc
    15541 ctggacatgc ccgaacccgc cgtccgggag ggcacgctcg ccctgccgcc cgtactgtcg
    15601 aagggcatcg agttccgcga ggtcaccttc acctacccgg gacagcgcga acccgtcctc
    15661 gacggcgtct ccttcaccgt gcccgccggc gcccgcgccg ctctcgtggg cagcaacggc
    15721 gccgggaagt ccaccctgat caagctgctg acccggttct acgaacccac cggcgggacg
    15781 atcctgatcg acggacggcc cctgagcgac tactcgctcc agggcctgcg ggaaggcatc
    15841 ggcgccatct tccaggacta ccaggagtac gaggccccgg tccgcgagaa catcggcttc
    15901 ggcaagcccg ccctgctcga cgacgacggg cggatccggg aggccgccca ccgggtcgga
    15961 gccctcgcct tcctcgacac cctccccgag ggcatcgaca cccggctcgg ccgctggttc
    16021 ccgggcggca gacagctctc cggcggtcag tggcagaagg tggccctggc ccgggcgctc
    16081 gtcggcgagg cccccgtact catcctcgac gagccgacgg cggccatcga cgccgccgcc
    16141 gaggcggaca tcctcgacgt cctgcggacc gtgggcacgg gggcgacctc cctgctggtc
    16201 gcccaccgct tctcggccgt ccggaccgcc gaccacatcg tggtgctcga cgggggcagg
    16261 gtcctcgaac agggctccca cgaacagctc atggagtccg gcggccggta cgcgtcgctg
    16321 ttcggcctcc aggcggccgg ataccgctga acgggcgggg cgggcgggcg gcggaggcgg
    16381 gggagggggc gcgtcagcgg gcggacgtcc ccagccccgc ctcccgggcc agcacgatgg
    16441 cctggccccg gctcgacaca ccgatcttgc cgagcacggc ggacacgtgg ttgcgtaccg
    16501 tcttgtccgc cagcgtcagc gtccgggcga tgcaccggtt gtcgaacccc cgcgccacca
    16561 gatcgaggat ctcccgctcc cggcgggtca gttccggcag gacctgccgc tccgccgtcc
    16621 ggccccccgt cgtcagcagc ccgctcagca cctggtccat cggcgatccg gcgaccatga
    16681 gcccccgcgc gaccatgtgg acggcgccga ccacctccgg tccgcccgcg tccttggcca
    16741 gacaccccct cacccccgcg agcagggcgg accgtaccag ggccgcgtcc gctccccgcc
    16801 ccgtcatgcc cagcaccgcc ctgcgccgcc ccgtacccgc catcagctcg cggcacacct
    16861 ccagggcggc ggaccccggc aggtccagat cgagcaggat cacatcgggc gccgcggcgc
    16921 ccaccagcgc gccgagcccc ggggccgagc cggtgtccat cacgacctcg atccccgcgg
    16981 ctgcggtcag ggccgcgcag atcccggcgc gcaggagcgg attgcgttcg acgacggcga
    17041 cgtggagcgg gctgtgcgaa acggatgcat acgtggtcaa ggctgcgact ccgatgagat
    17101 tccgacaggt tgccgcagca tgggaagtac ccgctagcgg atcactaggg agccgcccct
    17161 taccctccac acatgcgaag tgatcggggc gcgatgttcg agtaccggat cctggggccg
    17221 ctcgacgtgc ggcgcgcggg ccgagccgtg cccgtcaccg cccccaagga gcgcgacctg
    17281 atcacgctgc tcctgctgag ggccgaccgg accgtccccg ccgaggacct catcgacgga
    17341 ctctggggca ccacgccgcc cgcgaccgcc cgtaccaccc tgcagaacta catcaagcgg
    17401 ctgcgccgga tcctccagca gcccggcacc ggacaccccg agacgctcgt cacccggccg
    17461 ggaggctacc tgctgcgcct ggaggacgcc ttcctcgacc tcagggagtt cgacgggctg
    17521 gtacgggccg ccgccgaggc caccgcccgc ggggacgaca cgaccgccgc cgcccgcctc
    17581 gacgccgcgc tctcccactg gcgcggcgag gcgctgtccg gcagccgctc gcagcacctg
    17641 cggcaactgg aggcgccccg cctcgaagag tcccgtaccg tcgccttcga acagcgggta
    17701 gaggccggcc tgaggctggg aatgcacgcg gagctcatcg ccggactgcg cgtcgaggcg
    17761 gcacggcatc cgctgcggga acgcctccag gcacaactgg tgctcgccct ctaccgttcg
    17821 ggccgccgcg gcgacgcgct cgccgccgcc cgccaggccc gcgaccacct cgtacgggaa
    17881 ctgggcctgg agcccggccc ccacctcgcg cggctgcacg accggatcct ggccgacgac
    17941 ccggccctga tggacccgcg cccgaaggcc ccggcggtcg acgccgcgcc gggcgcgccc
    18001 accccgaccg ccccctcgac tcctccggga cggcccggac cggccgggcc cgaccccgcg
    18061 gccgcggcct cgctctccgt gctccccgcc caactcccgc cctccaccat ggtgttcacc
    18121 ggccgcgccg aagcgctccg gcgactcgac gaactgctgc ccactgccgg accccagccc
    18181 tccggcgcgg cccgcatcgc ccagatcagc ggccagggcg gagtcggcaa gacggccctg
    18241 gccgtccact ggggacacgg ccggcgcaac cggttccctg acggccagct ctacgtcaac
    18301 ctgcgcggac acggcggtca gcggccactg cggccggtcg acgccctcgg cggcttcctt
    18361 gaggcgctgg gcgtaccggc ccgggaagtc ccggtctcgg aggaccgctg cgcggcccgg
    18421 ttccgctcgc tgtgcgccgg ccggcggctg ctggtgatcc tggacgacgc cagctcggag
    18481 gaacaggtcc gacccctgct gcccggcagc gccgactgca tggtgatcgt gaccagccgc
    18541 cggaccctgg ccgggctggt ggcccgcgac ggcgccctgc ccgtgcccct gccggtcctg
    18601 gaaccgtccg aagcggaacg gctgttgatc aacatcctcg gagccggccg cgtctcgcgc
    18661 gaacccgggg cggccgccgc gctgaccgcc gcctgcgccc gtctgcccct cgccgtcggc
    18721 atcagcgcgg ccgacctcgc cctccacccg gagcggaccc tggccgagca ggtcgagcgg
    18781 ctcgtcgccg aggaccgcct ctccgcgctg gagctccccg gggacagcca cagcgcgctg
    18841 cgcaccgtct tcgcgatgtc ctacgccacc ctcgacccgg acgcggccag gatgttcggc
    18901 ctcctcggca ccatgccggg cgcggacatc accgtccgcg ccgcggccgc gctggccggc
    18961 gtgacgcgcg agcgctccca ggccctcctg gacgacctga cccgctccca cctcctcgac
    19021 gagggagccg tcggacggta cgccttccac gacctcctgc gcgcctacgc ccgcgaacgc
    19081 gtcctcgacg aacagcccga ggacgtgcgc agcgccgcca cggaccgcct ctacgcctgg
    19141 tacctggcca atgtcgacaa ggcggcgaag gtgatccagc cgcagatgct gcggctgggg
    19201 acctacacgg acggcgccga cctgtccttc gccaccccgg aggacgcggc cgggtggctc
    19261 gattccgaac gggccaatgt ggtggccatg gtccagcggg ccgccgagca cggcccccgg
    19321 gcggcggcct ggggcctggc cgacgccttc cggccgtacc tgatgcactc ctcgtacacc
    19381 gccgagtggc tggcggtggg cgaggccggg ctggcggccg ccgaagccga cgggaacgcc
    19441 gtcggtcagg cggccggcca ccgcatcctg tcgagcgcct acctcgtcct gggccggtac
    19501 gacgactgtg tccgccacga cctcgcggcc gtggagctct accacggcca ggggcacacc
    19561 agcggggaag cggcggcgta caacagcctc tcgctggccg cgtggtacgg aggccggctc
    19621 gacgacgcgg tggagtacgg caaccgcgga ctcgccatcg cgaggaccct ggaggacaag
    19681 gtccccgaac tcatcatcag caccaacgtg tgcggcatcc tccacgaggc cggcatgctg
    19741 cgggaggccg aggaacactt cgagggcatg atcggcggcc aggccgtgga ccagacgtcg
    19801 acgacggaaa gccacacctt caccaacttc gccgccctcc tgcacgaccg gggcctgccg
    19861 gagcgggccg cggaactcct cgcgaaggcc gaggcgatca ggcgccgcgc cggacaggcg
    19921 cccagcagcc tgagctacac cctgtactgg aaagcggtca tggcgctcca ggccggagac
    19981 cgggccagcg ccctggagca cgtggaggaa ggattctcca gcgcgggcgg cgacatcagg
    20041 gcccaggcgt acctgtacgt cgcccgaggg atgctcgccg agcgcaccgg ggggcacgag
    20101 acggccctgc gcagcttcca gcaggccagg gacctggccg aacagtgcgc ctcgcgcaaa
    20161 ccggaactcg aagctctgac ggggatggcg cgctgcaatc tgcgggcggg ccgcgtcgag
    20221 accgcgcgct ccttcgccga agagctgctg caggacgcca ccgccagcgg ctaccggctc
    20281 ttccacggct acgcgctgac gctcctggcc gagatcgcgt gcgaggaggg cgacccggcc
    20341 gaggcgcaac gccgggccgg ggaagcggcc gccgtccagg aggcgaacgg ccaccccagg
    20401 ggccgggccg aggcgctcat cgccctggcc cgagcgctcc gcgcggccgg cgacaccgag
    20461 ggcgcacggg cccgcgtcca ccaggcggcg cacctgtggt ccggcttcgc cccgcgccgc
    20521 gccgcaagca tcctgagcct ggccgactag tgtcctgaat ctctgactca ggacactagg
    20581 cggcctgccc caggtccagg tacgtcgccc gctgcaccac gcgcagccgg tcgaggactt
    20641 cggcgacctc cgcccggtcc ctgcggccgg cggcgaacgc cttcaggacc tcaaggaccc
    20701 gcgcggactt ccagcaccgc agcgcggcct cgtccaccag cttcggaccc gccacccgca
    20761 tcaggaccgc cagccgccgg cgagcgcgcc gcgccctgcg ccggccccac cagccctccg
    20821 gcgcccggtc gagggtgcgc agagcgtcca tccccttcac cagggcccgg atccgggcct
    20881 cttgcggggc cgtccagtcc cgcccccggc ggccgggaag cgcggacagg acctcctcga
    20941 cggccgcccg ggccgcggcc ggcccccgtt cgtccagcag ggtgacggcc gaccacagcg
    21001 aggtttccac cgcgggcgcg ttgtctcgtt cggacacgac ttaccccctc tccgttcctg
    21061 actcatgccc gcacgaccgc cacgcgcaac gcgaaggggg tgcagcggcc ctttcaggaa
    21121 cgcacggacc ggcgagatcc ggcccgcggg cctgggccgc ccgggtgagg gccgctccgc
    21181 tcacccgctc cgctcacccc cgcggctcac ccgcgcccct cacccgcgcg gctcaccccc
    21241 gcccagttcc cgctcggcgg catccagcag catctccagc gcgaccggat aggcactgtg
    21301 cggcatgcgc gcggccagca gcccggccgt cgccgcgatg ttcgggtact cccgcgccgg
    21361 cagccgggcg tacgtcgact cccaccgctc ctcgtccgag tcgcgcgcct tctccgacag
    21421 cgccagcgcc cccgcgtcga gcgccgcgaa ggccaggcac tggtcgatgt acgcgtggta
    21481 gatccgtacg gcgtccacgt ccccgaaccc cgccccccgc aggctcgcga ggatcgcctc
    21541 gtcggcggcg atctcgcgcg gccggccggt cacccggctc gcggtcagca gcgcggcctg
    21601 cgggtgcgcg aggtacgccc cgtggatgcg cagcccgagt gagcgcaggt cctcgcgcca
    21661 ccgcccggtc ggggcccagc cggcgagcgc ccggccgatc agctcctcgc cgatggccag
    21721 ggtcaggccg tccatgccgt cgaagtaccg gtacagggtg ctcggatccg cccccagggc
    21781 ggcgcccagc cgccgggcgg acaggcccgc gctgccgtgc tcgcgcacca tccgcagggc
    21841 cgtctcgacg atcagccgct cggagagcac cgtcccccgc cgcgtcggcc gccgccgtct
    21901 gcggcgctcc tccggaacca cgtccttcgc catccacccg ctcccgtcct tatgccaaca
    21961 ccattgacct taatccggag cacccggttc catcagtccc ctgaggcaca cgcctcacag
    22021 agaaaggacc tcgccatgcg tgttctgctc gtgggtgccg gcggtgtggg tagcgcgatc
    22081 accaagatcg ccgcccgccg cgacttcttc gaccacttcg tcgtcgccga ctacgacctg
    22141 acccgcgccg aggccgccgt cgccgccctc ggcgacgagg agcggcgctt cagcgcctgc
    22201 cgcgtcgacg cctccgacga gagcgccgtc acccggctgc tcaccgagcg cggctgcgac
    22261 gtcctgatga acgccaccga cccgcggttc gtgatgcccc tgttcaacgc cgcgctggcg
    22321 gcgggcagcc actacctcga catggcgatg tccctctccc gcccgcaccc cgaccacccg
    22381 caccgcgcat gcggcgtgaa gctcggcgac gagcagttcg aacgggccgc ggagtgggag
    22441 aagtcgggcc gcctcgccct cgtcggcatg ggagtcgagc ccggcctctc ggacgtcttc
    22501 gcccgctacg ccgccgacca cctcttcgac gagatcgagg agatcggcat ccgcgacggc
    22561 gccaacctga ccgtcgaggg ccacgacttc gccccgtcct tcaacatctg gaccacgatc
    22621 gaggagtgcc tgaaccctcc cgtggtctac gagcgcgagc gcggctggtt caccaccgaa
    22681 ccgttcagcg agccggaggt cttcgacttc cccgagggca tcggtcccgt cgagtgcgtc
    22741 aacgtggaac acgaggaggt cctcctcgtc ccgcgctggg tcggggcccg ccgggtcacc
    22801 ttcaagtacg gcctcggcga cgacttcatc ggcaagctca agacgctcca cgccctcggc
    22861 ctcgactcca ccgaccgggt cgccgtccga ggcgaggacg gccgcgaggt ccgcgtctcg
    22921 ccccgcgacg tggtcgccgc ctgcctgccc gacccggcga cgctcgggga ccgcatgacc
    22981 ggcaagacct gcgccggcac ctgggtcaag ggcaccaagg acggcctgcc ccgcgaggtc
    23041 tacctctacc acgtggtcga caaccagtgg tccatgcgcg agtacggctc ccaggccgtc
    23101 gtctggcaga ccgccgtcaa cccggtggtc gccctcgaac tcctcgccac gggcgtctgg
    23161 tcccagcccg gcgtcctggg ccccgaagcc ctcccgccca cccccttcct cgacctcctc
    23221 accgtctacg gctccccctg ggccatccgc gaacacccca ccccctgacc ccccgggcgt
    23281 cacccgaccg cgcgccgcgc cccaggtacg cccaggccgt cgccccggac cgcagcacca
    23341 cctcggtcct ggcgtagtcg tcgacctcac attcgtcggc cgcggccagc tccgacccgg
    23401 tgatccggaa cagggtccct gacacggcat cggcctaatc gccggaaagc acgaccacag
    23461 ggtgcaggtc gctgccgctc gccgcgatca cgtcggggtc cgtgatcctc acgaccgacg
    23521 tggtgtaccc cggcagcgcg tctggggctc cttccagaag cctcccgaac cgggccagct
    23581 gcacctgttc gagctgaagc gtgccgtagg agaacaacag gtacggcgcg gccatggaca
    23641 tgactactca cccgggagtc ggaaccgaca actacccctg aacctaaagc cagagcctcg
    23701 gcgcgtacca gccgtgtcgg aacaggccga ggagctgcgc gaacgaacca ggctcgaagc
    23761 ccgaaccgcg acgttcccgg ccagccgccc cggaccgttc ccgaggagga tggtacgagc
    23821 aaagtccgtc tcgcgtccgg tgcggcccgg gccgagcacg cgacgagtcc gtccgctcgc
    23881 tgaagaacca ctgggagcgg taggagaaag aacgcagcgg tagtggagcg ggttggacgg
    23941 acagggttct cgtcttcaca ccccgaccgg cggcccactc gaccctgcta acctctccga
    24001 ggcctcctcg accgggcatg gctgcgccgc acccgcttcc acaaccaacg gcactcgacc
    24061 gccaccctgc tctggtaata gggagtcgac ctcgtcgtca tccacctccc atgccaagcc
    24121 accaacaccc tgggcgatgc cctccacacg atcaacgatg ccgctgggga cccatccgcc
    24181 gtagcggtcg tccgccgacg cttccgtcgc cattcccgtc agacgcccgc tcggaagact
    24241 ccttatatcg caccctcccc gaagaagacg tcgccttact tgtggaggag caccggggtg
    24301 gagcctgcgg gagcacgtag taggcataag cgggccaatt tgccgcacac tgaacgctgt
    24361 tgtcgaaact atcagcggcc ccaacggaaa cgaatccgtt ggggccgctg agtaactacc
    24421 taagagctcg taacacgatc ttgatgagat gctctggtca gccgtgaccg gtgtgatgat
    24481 tcggccgttc gtggtggtgt gagtactcgg ccgtggatcg tggacgacga cttgtgggcg
    24541 ctgatcgagc cgctgctgcc gccctggccg gcgaggtcac cagg
//
