GCF_027697525.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAQESL010000001.1 (Coprococcus sp. AM97-35)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	269,953	290,843

NZ_JAQESL010000010.1 (Coprococcus sp. AM97-35)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	lanthipeptide-class-ii	1	18,907

NZ_JAQESL010000017.1 (Coprococcus sp. AM97-35)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	ranthipeptide	4,044	25,700

NZ_JAQESL010000041.1 (Coprococcus sp. AM97-35)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 36.1	cyclic-lactone-autoinducer	4,030	14,368

NZ_JAQESL010000043.1 (Coprococcus sp. AM97-35)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 38.1	lanthipeptide-class-ii	1	12,062

NZ_JAQESL010000059.1 (Coprococcus sp. AM97-35)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 55.1	lanthipeptide-class-ii	1	3,232

Region	Type	From	To
Region 1.1	terpene-precursor	269,953	290,843
Region 2.1	lanthipeptide-class-ii	1	18,907
Region 9.1	ranthipeptide	4,044	25,700
Region 36.1	cyclic-lactone-autoinducer	4,030	14,368
Region 38.1	lanthipeptide-class-ii	1	12,062
Region 55.1	lanthipeptide-class-ii	1	3,232

No secondary metabolite regions were found in these records:: NZ_JAQESL010000011.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000012.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000013.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000014.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000015.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000016.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000018.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000019.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000002.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000020.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000021.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000022.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000023.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000024.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000025.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000026.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000027.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000028.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000029.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000003.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000030.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000031.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000032.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000033.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000034.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000035.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000036.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000037.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000038.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000039.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000004.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000040.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000042.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000044.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000045.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000046.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000047.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000048.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000049.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000005.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000050.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000051.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000052.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000053.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000054.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000055.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000056.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000057.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000058.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000006.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000060.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000061.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000062.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000063.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000064.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000065.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000066.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000067.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000068.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000069.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000007.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000070.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000071.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000072.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000073.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000074.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000008.1 (Coprococcus sp. AM97-35); NZ_JAQESL010000009.1 (Coprococcus sp. AM97-35)

Compact view

NZ_JAQESL010000001.1 - Region 1 - terpene-precursor

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Location: 269,953 - 290,843 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase

PG840_RS01285: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: back translocase

PG840_RS01355: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase

PG840_RS01320: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

PG840_RS01325: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.38	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0000663.5	0.38	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.39	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.38	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0000663.5	0.38	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

PG840_RS01325: PT_FPPS_like

Domain 1 (31 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.45 out of 27.78

Confidence: medium

Additional weak hits (2):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.00 out of 39.62

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.96 out of 30.22

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAQESL010000010.1 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 18,907 nt. (total: 18,907 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

PG840_RS09150: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.44	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000504.5	0.37	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000539.5	0.35	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.34	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000521.3	0.33	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001407.5	0.33	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.44	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000504.5	0.37	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000539.5	0.35	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.34	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000521.3	0.33	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001407.5	0.33	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PG840_RS09150

PG840_RS09145

Leader:

MRKFDRTNMKYNNPAGDLLTELEAA

Core:

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

Core with dehydrations:

DLDhbDhaNKVDDhaLADhaDhaGVVCysDhbIDhaVECysGDhaIFDhbLACysCys

antiSMASH-DB 4.0 matches for PG840_RS09145

100.0%

NZ_JAQDBP010000004.1and 18 others:

NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptideNZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptideNZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptideNZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptideNZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptideNZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptideNZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide

Lanthipeptides: PGY07_RS07085_lanthipeptide

1

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

32

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

1

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

32

62.5%

NZ_CP022413.2and 1 other:

NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide

Lanthipeptides: CGC63_RS01420_lanthipeptide

13

SGVVCTISVECGSIFTLACC

32

SGVVCTISVECGSIFTLACC

1

SGVVCTISVECGSIFTLACC

20

40.6%

NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

13

SGVVCTISVEC-----GSIFTLACC

32

GVV T+S EC SIFT CC

5

QGVVPTVSYECRMNSWQSIFT--CC

27

with 122 more sequence matches

Only the first 10 are displayed here.

37.5%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

11

ASSGVVCTISVECGSIFTLAC

31

ASSG CT+++ECG+ F AC

1

ASSGWFCTLTIECGT-FICAC

20

37.5%

NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

11

ASSGVVCTISVECGSIFTLAC

31

ASSG +CT+++ECG+ F AC

1

ASSGWLCTLTIECGT-FICAC

20

36.4%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

12

SSGVVCTISVECGSIFTLACC

32

S G CTI+ EC +FT+ACC

14

SCGRACTITAEC-PVFTVACC

33

34.4%

NZ_CP069183.1:

Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

11

ASSGVVCTISVECG---SIFTLACC

32

SGV+ TIS EC F CC

2

GGSGVIHTISHECNMNSWQFVFTCC

26

34.4%

NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

11

ASSGVVCTISVECGSIFTLACC

32

ASSG +CT + EC + F+ CC

1

ASSGAICTATTEC-TYFSAICC

21

32.4%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

12

SSGVVCTISVECGSIFTLACC

32

S G CTI+ EC I T+ CC

15

SCGRRCTITTEC-PIATVVCC

34

32.4%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

11

ASSGVVCTISVECGSIFTLACC

32

AS G +CT + EC I T+ CC

14

ASCGRLCTGTAEC-PIMTIICC

34

31.2%

NZ_AP025017.1:

Lanthipeptides: MANAM107_RS05920_lanthipeptide

13

SGVVCTISVECG---SIFTLACC

32

+GV+ TIS EC F CC

1

NGVITTISHECHLNTWAFAFTCC

23

31.2%

NZ_CP034248.1:

Lanthipeptides: EIM92_RS14995_lanthipeptide

11

ASSGVVCTISVEC

23

AS GV+CTIS EC

5

ASGGVICTISHEC

17

31.2%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

12

SSGVVCTISVECGSIFTLACC

32

SSG +CT++ EC + T CC

7

SSGDICTLTSECDHLATWVCC

27

MIBiG 4.0 matches for PG840_RS09145

21.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

10

LASSGVVCTISVEC

23

L + G CT++VEC

10

LGNKGAYCTLTVEC

23

18.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

DSLASSGVVCTISVEC

23

++L ++G CT++ EC

10

NALGNNGGWCTLTKEC

25

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

17

CTISVECGS

25

CT+S EC

28

CTLSKECQP

36

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.31 out of 28.14

Confidence: medium

Lanthipeptides

TFBS Finder

Core peptide predictions

PG840_RS09145 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3059.5 Da

Molecular weight: 3061.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3079.5 Da N = 1; 3097.5 Da N = 2; 3115.6 Da N = 3; 3133.6 Da N = 4; 3151.6 Da N = 5

TFBS definitions

Regulator	Description
PerR	Peroxide regulator

NZ_JAQESL010000017.1 - Region 1 - ranthipeptide

Download region GenBank file

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Location: 4,044 - 25,700 nt. (total: 21,657 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transferase

PG840_RS11700: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: hydrolase

PG840_RS11635: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: dehydratase

PG840_RS11690: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

PG840_RS11695: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000794.5	0.54	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000790.3	0.54	saccharide	O-antigen	Escherichia coli
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000766.3	0.51	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000767.3	0.49	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000773.3	0.49	saccharide	lipopolysaccharide	Escherichia coli
BGC0000899.4	0.49	saccharide	desosamine	Streptomyces narbonensis
BGC0000792.3	0.48	saccharide	polysaccharide	Enterococcus faecalis OG1RF

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000794.5	0.54	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000790.3	0.54	saccharide	O-antigen	Escherichia coli
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000766.3	0.51	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000767.3	0.49	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000773.3	0.49	saccharide	lipopolysaccharide	Escherichia coli
BGC0000899.4	0.49	saccharide	desosamine	Streptomyces narbonensis
BGC0000792.3	0.48	saccharide	polysaccharide	Enterococcus faecalis OG1RF

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.07 out of 18.46

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19

Confidence: medium

Additional weak hits (3):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.08 out of 20.47

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.81 out of 32.74

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 111; Score: 94.1

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 1	Zinc-responsive repressor

NZ_JAQESL010000041.1 - Region 1 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 4,030 - 14,368 nt. (total: 10,339 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000620.3	0.40	ribosomal	lacticin Q	Lactococcus lactis
BGC0000563.4	0.36	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000571.3	0.35	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002116.3	0.32	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0002447.3	0.31	ribosomal	cerecyclin	Bacillus cereus
BGC0000600.3	0.28	ribosomal	thurincin H	Bacillus thuringiensis
BGC0001388.3	0.27	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.27	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.27	ribosomal	gassericin-T	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000620.3	0.40	ribosomal	lacticin Q	Lactococcus lactis
BGC0000563.4	0.36	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000571.3	0.35	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002116.3	0.32	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0002447.3	0.31	ribosomal	cerecyclin	Bacillus cereus
BGC0000600.3	0.28	ribosomal	thurincin H	Bacillus thuringiensis
BGC0001388.3	0.27	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.27	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.27	ribosomal	gassericin-T	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.57 out of 30.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JAQESL010000043.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 12,062 nt. (total: 12,062 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

PG840_RS15985: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000527.5	0.47	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000539.5	0.47	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001787.3	0.47	ribosomal	suicin 3908	Streptococcus suis
BGC0000547.5	0.46	ribosomal	salivaricin 9	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000527.5	0.47	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000539.5	0.47	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001787.3	0.47	ribosomal	suicin 3908	Streptococcus suis
BGC0000547.5	0.46	ribosomal	salivaricin 9	Streptococcus salivarius

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PG840_RS15985

PG840_RS15950

Leader:

MEGNTSKENLKSCRVQGKYAGTVEDIHKGTVFVRLELGVNAIA

Core:

HSCYDSRTVGKKDKVSFVVTHIDEERNV

Core with dehydrations:

HDhaCysYDDhaRDhbVGKKDKVDhaFVVDhbHIDEERNV

antiSMASH-DB 4.0 matches for PG840_RS15950

100.0%

NZ_JAQESL010000043.1:

Lanthipeptides: PG840_RS15950_lanthipeptide

1

HSCYDSRTVGKKDKVSFVVTHIDEERNV

28

HSCYDSRTVGKKDKVSFVVTHIDEERNV

1

HSCYDSRTVGKKDKVSFVVTHIDEERNV

28

32.1%

NZ_AUJG01000009.1and 1 other:

NZ_FNUL01000010.1 Lassopeptides: allorf_098220_098354_lassopeptide

Lassopeptides: allorf_05182_05316_lassopeptide

10

GKKDKVSFVVTHIDEERNV

28

GK K SF IDE N+

1

GKSIKPSFDAFRIDENGNL

19

21.4%

NZ_CP035119.1:

Lanthipeptides: EP007_RS17290_lanthipeptide

1

HSCYDSRTVGKKDKVSF

17

H C K DK++F

6

HGCMMQAVTNKADKLTF

22

with 1 more sequence matches

20.0%

NZ_CP034351.1and 1 other:

NZ_CP034351.1 Lanthipeptides: D1J60_RS35670_lanthipeptide

Lanthipeptides: D1J60_RS35670_lanthipeptide

8

TVGKKDKVSFVVTHIDE

24

T G K S +++ +DE

7

TCGSKSATSTIISCVDE

23

PG840_RS15980

Leader:

MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS

Core:

QFCTSTKECNWGTIMFVCC

Core with dehydrations:

QFCysDhbDhaDhbKECysNWGDhbIMFVCysCys

antiSMASH-DB 4.0 matches for PG840_RS15980

100.0%

NZ_CP102267.1and 11 others:

NZ_FMUW01000051.1 Lanthipeptides: BLP57_RS16830_lanthipeptideNZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07130_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: PGR68_RS13915_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: PG840_RS15980_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: PG808_RS00050_lanthipeptideNZ_LN913006.1 Lanthipeptides: BN3261_RS01470_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: DWZ74_RS14610_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03120_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06255_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03580_lanthipeptide

Lanthipeptides: NQ550_RS04155_lanthipeptide

1

QFCTSTKECNWGTIMFVCC

19

QFCTSTKECNWGTIMFVCC

1

QFCTSTKECNWGTIMFVCC

19

42.9%

NZ_QRHZ01000008.1and 2 others:

NZ_QSRF01000021.1 Lanthipeptides: DXC87_RS15310_lanthipeptideNZ_QUEQ01000033.1 Lanthipeptides: DXA48_RS19000_lanthipeptide

Lanthipeptides: DW272_RS13830_lanthipeptide

2

FCTSTKECNWGTIMFVCC

19

FCTST ECN GT+ CC

11

FCTSTGECNMGTLNIFCC

28

40.0%

NZ_JAFCGV010000005.1:

Lanthipeptides: JQI09_RS04275_lanthipeptide

4

TSTKECNWGTIMFVCC

19

T+T EC GT FVCC

7

TATSECYLGTFAFVCC

22

with 18 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_WBPF01000002.1:

Lanthipeptides: F8162_RS00195_lanthipeptide

1

QFCTSTKECNWGT--IMFVCC

19

QF T + EC+W T +F CC

4

QFDTISHECHWNTWQFLFTCC

24

36.0%

NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

4

TSTKECNWGTIMFVCC

19

T+T EC GT F CC

7

TATSECYLGTFAFACC

22

34.6%

NZ_CP117876.1:

Lanthipeptides: PQ460_RS01735_lanthipeptide

4

TSTKECNWGTIMFVCC

19

T+T EC GT+ F+CC

7

TATSECYLGTVAFICC

22

33.3%

NZ_CYXV01000003.1:

Lanthipeptides: ARB75_RS04585_lanthipeptide

3

CTSTKECNWGTIMFVCC

19

CT T ECN GT + CC

12

CTLTGECNIGTHIKFCC

28

29.2%

NC_012470.1and 42 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

4

TSTKECNWGTI--MFVCC

19

T + EC W ++ +F CC

7

TISAECRWNSLQAIFTCC

24

29.2%

NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

4

TSTKECNWGTI--MFVCC

19

T + EC W ++ +F CC

7

TISAECRWNSLQAIFSCC

24

27.6%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

1

QFCTSTKEC

9

QFCT TKEC

15

QFCTLTKEC

23

26.3%

NZ_CP059557.1:

Lanthipeptides: H2Q94_RS19875_lanthipeptide

7

KECNWGTIMFVC

18

+ C+WG + VC

3

QSCSWGPVTAVC

14

25.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

1

QFCTSTKEC

9

Q+CT TKEC

15

QWCTLTKEC

23

24.1%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

1

QFCTSTKEC

9

+FCT TKEC

15

RFCTLTKEC

23

MIBiG 4.0 matches for PG840_RS15980

26.3%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

7

KECNWGTIMFVC

18

+ C++G FVC

3

QSCSFGPFTFVC

14

20.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

2

FCTSTKEC

9

+CT TKEC

18

WCTLTKEC

25

17.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

2

FCTSTKEC

9

+CT T EC

16

YCTLTVEC

23

with 3 more sequence matches

13.6%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

9

CNWGTIMFVCC

19

C + ++ V C

10

CEYSSLSVVLC

20

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

3

CTSTKEC

9

CT +KEC

28

CTLSKEC

34

10.8%

BGC0001229.4 (SBI_06989)and 1 other:

BGC0002110.3 (QKV49894.1) Lanthipeptide: birimositide

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

2

FCTSTK

7

FC +TK

27

FCPTTK

32

allorf_02084_02182

Leader:

MIRSSIIFFVLNKLQGS

Core:

CQVSVRFLSEKYIIL

Core with dehydrations:

CysQVDhaVRFLDhaEKYIIL

antiSMASH-DB 4.0 matches for allorf_02084_02182

100.0%

NZ_CP102267.1and 7 others:

NZ_JAQDBP010000004.1 Lanthipeptides: allorf_177044_177142_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: allorf_20164_20253_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: allorf_02084_02182_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: allorf_017059_017148_lanthipeptideNZ_LN913006.1 Lanthipeptides: allorf_0097924_0098022_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: allorf_103379_103477_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: allorf_092199_092297_lanthipeptide

Lanthipeptides: allorf_0889319_0889417_lanthipeptide

1

CQVSVRFLSEKYIIL

15

CQVSVRFLSEKYIIL

1

CQVSVRFLSEKYIIL

15

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.55 out of 30.11

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PG840_RS15950 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 3157.6 Da

Molecular weight: 3159.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3177.5 Da N = 1; 3195.5 Da N = 2; 3213.5 Da N = 3; 3231.5 Da N = 4

PG840_RS15980 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2127.9 Da

Molecular weight: 2129.5 Da

Number of bridges: 4

allorf_02084_02182 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 1761.0 Da

Molecular weight: 1762.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1780.1 Da N = 1

TFBS definitions

Regulator	Description

NZ_JAQESL010000059.1 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 3,232 nt. (total: 3,232 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

PG840_RS16500: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000532.3	0.51	ribosomal	mutacin II	Streptococcus mutans
BGC0000626.3	0.48	ribosomal	thuricin	Bacillus thuringiensis
BGC0000548.4	0.47	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000520.5	0.43	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0002110.3	0.42	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000532.3	0.51	ribosomal	mutacin II	Streptococcus mutans
BGC0000626.3	0.48	ribosomal	thuricin	Bacillus thuringiensis
BGC0000548.4	0.47	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000520.5	0.43	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0002110.3	0.42	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.05 out of 25.88

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description