LOCUS       NZ_JAQCYD010000005     12887 bp    DNA     linear   CON 23-FEB-2024
DEFINITION  Streptococcus mutans strain AF36-21BH AF36-21BH.Scaf5, whole genome
            shotgun sequence.
ACCESSION   NZ_JAQCYD010000005
VERSION     NZ_JAQCYD010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 174326)
  AUTHORS   Lin,X., Hu,T., Chen,J., Liang,H., Zhou,J., Wu,Z., Ye,C., Jin,X.,
            Xu,X., Zhang,W., Jing,X., Yang,T., Wang,J., Yang,H., Kristiansen,K.,
            Xiao,L. and Zou,Y.
  TITLE     The genomic landscape of reference genomes of cultivated human gut
            bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 174326)
  AUTHORS   Zou,Y., Lin,X. and Hu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2022) BGI Reaserch, BGI-Shenzhen, Beishan
            Industrial Zone, Shenzhen 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: MGI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/23/2024 01:23:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,988
            CDSs (total)                      :: 1,943
            Genes (coding)                    :: 1,890
            CDSs (with protein)               :: 1,890
            Genes (RNA)                       :: 45
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 38
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 53
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 33 of 53
            Pseudo Genes (incomplete)         :: 28 of 53
            Pseudo Genes (internal stop)      :: 23 of 53
            Pseudo Genes (multiple problems)  :: 22 of 53
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:29:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 12887
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQCYD010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12887
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     gene            <1..178
                     /locus_tag="PGX70_RS06975"
                     /pseudo=""
     cand_cluster    1..12887
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="interleaved"
                     /product="RRE-containing"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..12887
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2563:2887](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2564..2887
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     protocluster    1..12567
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[388:2567](+)"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      389..2567
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="2"
     CDS             <3..178
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311998.1"
                     /locus_tag="PGX70_RS06975"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /pseudo=""
                     /transl_table=11
                     /translation="KVKLFDVYAGEKLGQGKKSMAYSLTFQNPNDNLTDEEVAKYMEKI
                     TSALTEKVGAEVR"
     gene            389..1246
                     /locus_tag="PGX70_RS06980"
     CDS             389..1246
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804849.1"
                     /locus_tag="PGX70_RS06980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rgg/GadR/MutR family transcriptional regulator"
                     /protein_id="WP_002313012.1"
                     /sec_met_domain="TIGR01716 (E-value: 2.2e-49, bitscore:
                     161.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEYGKIFKKFRESRGLKMKEVAGSNLSTSHLSRFENGESELTIS
                     KLMTALYEINMPIEEFMYAANDFHQDELNELLKDVRECVNNKDVERLKAVLIKQQENLK
                     EGRIFHHLNVILVKIRLQDLSGETYYSKADLVYLTNYLFKVEYWGFYELLLFTNTIDVF
                     KHETFMVLSREMMRRSDFYKEIPRNRRLISRMALNSFITCIERDKLIDALYFEKQLSIC
                     HFDETEIYERLVFHYAQNLFAYKKYKTTLAIIEMKKSVAAMKLAGSLHIAETYENHLQK
                     ILEG"
     misc_feature    complement(1294..1307)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 26.23"
                     /tool="antismash"
     gene            1452..2567
                     /locus_tag="PGX70_RS06985"
     CDS             1452..2567
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265228.1"
                     /locus_tag="PGX70_RS06985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="radical SAM protein"
                     /protein_id="WP_002270807.1"
                     /sec_met_domain="PF04055 (E-value: 6.4e-23, bitscore: 75.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 6.1e-48, bitscore:
                     157.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.1e-12, bitscore: 40.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 9.9e-10, bitscore: 31.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-13, bitscore:
                     44.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.1e-11, bitscore: 38.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDYSPYPLLVDVCVTNRCNLSCSYCSAEAGPFASKKGEMSVEKL
                     DSIFRELNLMGVPRVGVTGGEPFIRDDILDILKAFDKYHFAKVLNTNGNLITDSVAKEL
                     SKLHLDRICVTVDGSCSKVHDSQRGKGSFKKAIEGIKNLQRYNLPVSTLFTLGRHNVDD
                     LINTIRLNDMLRIKYMSVMIICPTGRANDGSILADKKHWYPVFLDLTERLSRGEFKVKF
                     KIVPPNESDVFWTHYFPLAFYNRLDLLESVWHQSLNFNSNKKREISCQAGVRACSINHK
                     GDVYGCDLMNGIDELVAGNVKEKSFYEIWHNSSIFHKLRNITFDDISGKCAGCPLPWCG
                     GGCRCSALELDGTLLGSDLACFYDEEESVLV"
     gene            2564..2887
                     /locus_tag="PGX70_RS06990"
     CDS             2564..2887
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265227.1"
                     /locus_tag="PGX70_RS06990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_002265227.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.8e-10,
                     bitscore: 34.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 4.8e-40, bitscore:
                     129.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.7e-09, bitscore: 29.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNHFTIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYC
                     ISKNFSLDKIIEVIQEEYDVTYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFR
                     EAL"
     aSDomain        2579..2800
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PGX70_RS06990_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.00E-11"
                     /identifier="RREFam002.1"
                     /label="PGX70_RS06990"
                     /locus_tag="PGX70_RS06990"
                     /protein_end="79"
                     /protein_start="5"
                     /score="34.2"
                     /tool="antismash"
                     /translation="TIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNF
                     SLDKIIEVIQEEYDVTYDDCKKAIVHFLE"
     aSDomain        2579..2878
                     /aSDomain="Streptide_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM enzyme in a
                     streptide-like cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PGX70_RS06990_Streptide_RRE.1"
                     /evalue="8.00E-41"
                     /identifier="RREFam022.1"
                     /label="PGX70_RS06990"
                     /locus_tag="PGX70_RS06990"
                     /protein_end="105"
                     /protein_start="5"
                     /score="129.5"
                     /tool="antismash"
                     /translation="TIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNF
                     SLDKIIEVIQEEYDVTYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFRE"
     gene            2884..4164
                     /locus_tag="PGX70_RS06995"
     CDS             2884..4164
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803472.1"
                     /locus_tag="PGX70_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_002265226.1"
                     /transl_table=11
                     /translation="MSYSKEVNRYVFPLVATNLVQVLIGQISLHFAVDNSNAALSGISV
                     IQNFLFAFGGILGAFSLSFNIRGAKAFYNKEYQRFKNLLKSSLLIDIGIGLSFILFCLG
                     LSRPFLKVFYGFDGQLLELSTTYFKIMSPYILLTLLIFLFSNLLKIEKKTKPIFWIGTL
                     SSVLDVLLNYYLVPLLGIRGAAISSILSLLVIVLGYFIFVKSLVFQALQEASTSKLELI
                     RFGIPLSIQEILESVLFIMAFDAFMGRQGLRILSIYAVVSQLFAIVRTPAFMYAGSIAI
                     FLPEARKKEDEKALIATIFRNSYAVIFIFACLVTVFSNPFAHFLSDEVIDNVLPFTLYT
                     VVVMGATPLYESSKMLLQSNDDEQWVLKITSIVNILSILILLVLQLMGKQTYQSLYGIY
                     GLSLIVLSILFIKRNSEKRVSSRKMTM"
     misc_feature    complement(4338..4353)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    complement(4633..4646)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            4938..5264
                     /locus_tag="PGX70_RS07000"
     CDS             4938..5264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803471.1"
                     /locus_tag="PGX70_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002266136.1"
                     /transl_table=11
                     /translation="MTHVVSEIFKDGPVDRFGLRGDPVFWNYLEKHFQKVAMPYSERKL
                     EEDIRTIYQDLTGKEFRMGEMALVKDFISKSGGMSSGWLSDDFWLKSAIPLLKKRLAKW
                     NETL"
     gene            5439..5684
                     /locus_tag="PGX70_RS07005"
     CDS             5439..5684
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261618.1"
                     /locus_tag="PGX70_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SemiSWEET family transporter"
                     /protein_id="WP_002262921.1"
                     /transl_table=11
                     /translation="MLILGWVATFMSIMMYVSYIPQIMNNLAGNKGDFIQPSVAALNCT
                     LWVIYGLCKEKRDLPLAAANMPGIVFGLIAAITALV"
     gene            6553..9795
                     /gene="rexB"
                     /locus_tag="PGX70_RS07010"
     CDS             6553..9795
                     /GO_process="GO:0000724 - double-strand break repair via
                     homologous recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="rexB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012997660.1"
                     /locus_tag="PGX70_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="WP_270513825.1"
                     /transl_table=11
                     /translation="MKLLYTDIPYNITEILAEEAQIAAKAGKRVFYIAPNSLSFEKERA
                     VLETLPERASFAITITRFEQMARYFVLNDIHQGETIDDNGLAMVFYRALSSFSDQDLRV
                     FGRLKQDAHFINQLVDLYKELKASNLTVLELNQLNSAEKQEDLIKIFTEVETILSAGHF
                     DNQSKIAFFAQQIKFGHLDTALQDLTIVVDGFTRFSAEEENLIGLLYEKGVDIIIGTYI
                     SQKAYRSTFSNGNVYQASLDFIRNLAGKFQTKPEYVVSKQEALPAFTKLSQLFESCHDF
                     SDSQLVLTDKDKEHVTIWDVINQKEEVEHVAKSIRRKLYEGHRYKDILVLLGDVDAYKL
                     QIGKIFDKYEIPYYFGKAESMSSHPLVHFVDSLERVKRYNFRAEDVMNLLKSGLYGKIR
                     QNQLDKLEQYVIYADIKGKTKFFKDFTLDNHGQFDLKALNKLRAEVMSPLQELVKIQAQ
                     KGDSILQKLTNFLEAISLTNNFSKLIQGVSDTEQEKNEQVWKTFTVILEQFHTIFGQEK
                     MKLADFLALLRSGMLAADYRTVPASVDVVTVKSYDLVEPHSNKFVFALGMTQSHFPKIV
                     QNKSLISDEERAKINEATPDNRRFDIVTKENLKKNHFTALSLFNAATQELVLTLPQILN
                     EAEDNTSSYLLELQDMGVPVVEKGGNRLAADPEDIGNYKALLSRVIELNRSAIDQELSK
                     EEQTFWSVAVRYLRQKLAKEGLTIPEVNDKMQTKQVAAEVMAARFPIDQPLNLSSSALT
                     TFYNNQYLYFLQYILGLQELETIHPDARNHGTYLHRVFELVMQDQSTDDFDSKLNRAID
                     ITNHEDSFHLVYNEDEESRYALGILEDIARSTATVLKGDNPVQAESEEEAFELMLDQAV
                     KIRGVIDRIDRLSDGSLGIVDYKSSKNTFDLQKFYNGLSPQLVTYIEALRSCKNLNDTD
                     KIFGAMYLHMQEPKTDLANMKSIEKIPETVHKNLSYKGLFLEDEKAHLANGKYHLHDAV
                     YSQKEVDLLLDYNKRLYRSAAKQIRKGNFLINPYSQDGKSVQGEQLKAITHFEADRHMP
                     YARKLYQLPRKEKRQGFLALMQSKKEEEGNDL"
     misc_feature    complement(10704..10714)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    12604..12618
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.01"
                     /tool="antismash"
     misc_feature    12796..12811
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.01"
                     /tool="antismash"
ORIGIN
        1 caaagtaaaa ctctttgacg tttatgctgg tgaaaaattg ggacaaggta agaaatcaat
       61 ggcctacagc ctgactttcc aaaatcctaa tgataatctc acagatgaag aagttgccaa
      121 atacatggaa aaaatcactt cagccctaac cgaaaaagtt ggtgcagaag tgaggtaacg
      181 aaaaaatcta ccttcaaagg tagatttttt tggtatgtaa gctagtgagc ctacccaccg
      241 ccgataatga taattgtttc taataccact atcaaagtca taaaaatttt atttctcatg
      301 tttttctcct cactcacttt tcttatatgt tataataaat tgcaattaac tgaatataaa
      361 tcccatatag acaattgagg tactattgat gactgaatat ggaaaaatat ttaaaaaatt
      421 tagagaatca cgcggtctaa aaatgaagga agtagctggt tcaaatttat caacttcaca
      481 tctttcaaga tttgaaaatg gagaatctga gctgacaata agtaaactta tgacagcact
      541 gtacgaaata aatatgccta ttgaagaatt tatgtatgct gccaatgatt tccatcagga
      601 tgaattaaat gagctcctta aagatgtgag ggagtgtgtt aataataaag atgttgaacg
      661 attaaaagcg gtattgatta agcaacaaga gaatttaaaa gaaggtcgaa tttttcacca
      721 tttgaatgtt attctagtaa aaataaggtt gcaagattta tccggtgaaa cttattatag
      781 taaagcagac ctagtttact taacaaatta cttatttaaa gttgaatact ggggtttcta
      841 tgagctgtta ctttttacga atactattga tgtttttaaa catgaaactt ttatggttct
      901 ctctagagag atgatgagac ggtcagattt ttataaagaa atacctcgaa atcgacgtct
      961 tatttcacgt atggctctga attcttttat aacttgcatt gaaagagata aactgattga
     1021 tgcactgtat tttgaaaaac aattaagcat ctgtcatttt gatgaaacag aaatttatga
     1081 acgcttggtc tttcattatg ctcaaaatct atttgcctat aaaaaatata agacgacact
     1141 tgctattatt gaaatgaaga aatcagtagc agcaatgaaa ttggcaggga gtttgcatat
     1201 tgctgaaacc tatgaaaacc atcttcaaaa aattttagaa ggataatatg aaattgtgta
     1261 tatgggataa aaatctctct ttttggattt gatttataat aattctatca aatcaaggag
     1321 gtaaatacta tgttgactaa aaaagagttt agtgttccta aaacaactaa ggtaaactgt
     1381 tggggtaagc actagtaaaa caaggtctgt aggtcattgc atggcttaca gattttttag
     1441 gaggtatttt aatgagagat tattcaccat atccgttatt ggttgatgtt tgtgtaacaa
     1501 atcgttgtaa tttaagttgt tcatattgtt cagcagaagc aggccctttt gccagtaaaa
     1561 aaggagagat gtctgttgag aagctggatt ctattttccg tgaattaaat ttaatgggag
     1621 ttccgcgagt aggtgttact ggaggtgaac cgtttattag agatgatata ttagacatct
     1681 taaaggcttt tgataaatat cattttgcta aagttttaaa tactaatggt aacctcatta
     1741 cagattctgt agctaaggaa ttatctaaac tgcatttgga tagaatttgt gtgaccgtgg
     1801 atggaagttg ctctaaagtt catgatagcc aaagaggtaa aggaagcttt aaaaaggcaa
     1861 tagagggtat taaaaattta caaaggtata atcttcctgt ttctacactt tttacattag
     1921 gaaggcacaa tgtagatgat ttgattaaca ctattaggtt aaacgatatg cttagaatta
     1981 aatatatgtc tgtaatgatt atttgcccaa caggtagagc taatgatgga agcattctag
     2041 cagataagaa acattggtat cctgtatttt tagatttaac agagagattg tctcgtggag
     2101 aatttaaagt gaagtttaaa atagttcctc caaatgaaag tgatgtcttt tggacacatt
     2161 atttcccact agctttttac aaccgattag atttacttga aagtgtatgg catcaaagcc
     2221 tgaactttaa tagtaacaag aaaagagaaa tatcttgcca agctggagta agagcttgtt
     2281 ctatcaacca taaaggtgat gtttatggtt gtgatttgat gaacggcatt gatgaacttg
     2341 tagcaggtaa tgtaaaagaa aaatcttttt atgaaatttg gcataattct tctatatttc
     2401 ataaattgag aaatattaca tttgacgata tttcggggaa atgtgctggt tgccccttac
     2461 cttggtgtgg tggtggatgt agatgcagtg cactggagtt agatggaact ttgcttggat
     2521 ctgatttagc atgtttttat gatgaagagg aaagcgtatt ggtatgaaaa atcattttac
     2581 aataaaaggg aagagagatt ttgttgttga taaaattgac gatgagttta taggatatga
     2641 tagattagat ctagagtatt attcttttga tgatataggt gctgaaattt tatattgtat
     2701 ttctaaaaac ttttctttgg acaaaatcat tgaggtcatt caagaagagt atgatgtgac
     2761 ttatgacgat tgtaagaaag ctattgtcca ttttttagag gagacaccta tattacatat
     2821 tatttatgca aatcttatta aatcagacat ttatttatac ctaaaaccat ttcgggaggc
     2881 attatgagtt attctaaaga ggtgaaccgt tatgtttttc ctctcgttgc cacaaacctt
     2941 gttcaagttt tgattggtca aatttctctt cattttgctg tcgataattc taatgctgct
     3001 ctgtctggca tttctgttat ccagaatttt ctttttgcat ttggaggtat tcttggagcc
     3061 tttagtttgt cgtttaatat tagaggtgcc aaggcttttt ataataaaga ataccaacga
     3121 tttaaaaatc ttttaaaatc atccctgcta attgatattg gaattggact gtcattcatt
     3181 cttttttgtc tgggattgag cagacctttt ttgaaagttt tttatggttt tgatggtcaa
     3241 ttattggaac tatcgactac ctattttaag atcatgtctc cttatatttt attgacctta
     3301 ttaatctttc ttttttcaaa tcttttgaaa attgagaaga aaacaaagcc cattttttgg
     3361 attggaaccc taagttccgt gctagatgtc ttgttaaact attacttagt tcctcttttg
     3421 ggaattcgtg gagctgctat ttcgtctatt ttatcgctgc tagtcattgt tttagggtat
     3481 ttcatttttg taaaatctct tgtttttcaa gcgcttcaag aggcttcgac aagtaagtta
     3541 gagcttatcc gttttggaat ccctttatcc atacaagaaa tactggagag tgttttattt
     3601 atcatggctt tcgacgcttt catgggaaga caagggctac gcattttgtc catctatgcg
     3661 gtagtcagtc aattatttgc aattgtgaga acacctgcct ttatgtatgc gggttcaata
     3721 gcaatctttt tgcctgaagc taggaaaaaa gaagacgaaa aagcattgat tgcaactatt
     3781 tttagaaata gctacgctgt tatatttata tttgcttgtt tagtaacagt attttcaaat
     3841 ccttttgctc attttttgtc tgatgaagtt attgataatg tgctgccttt tactttgtat
     3901 acggttgtgg tcatgggagc aacacctcta tatgaaagct ctaagatgct tttgcaaagc
     3961 aatgatgacg aacaatgggt tttaaaaata acaagcattg tcaatatatt aagtatcctt
     4021 atcttattag ttctccagtt aatgggcaag caaacctatc aatctctgta tggcatttat
     4081 ggtttgagtt taatagtgct tagtattctt ttcataaaaa gaaatagtga gaagagagta
     4141 tcatcacgta aaatgacaat gtaaggcttg tagggagtaa tacaagtctt ttttagaact
     4201 ttaatgaata aaagtttttt gacagtttac actagtttca cctaaaaaat attatcgatt
     4261 tttcaaacga aacgtcgcag taatctttgg tggctacatt aggaggtgat ctaaggcctt
     4321 gaaaatccct ttgaagattg acaaatcagt taatcaatct tcttctgccc acggtggtac
     4381 ctatagttct tagtgacctt acggtcgctt tcgataagct aatgttttag gcaataagta
     4441 ggaaatctat gaatatgggt tcttaatatc tcaaagtaaa actctttgac gtttatgctg
     4501 gtaaagaagt tgccaaatac atggaaaaaa tcaccaaagc cctaaccgaa aaaattggtg
     4561 cagaagtgag gtaaaaattg acagctgata agcttatagc cgtctgtttc ttatttttaa
     4621 acagataact tagcaaggac agtgcccatc aacgatgttt gctgttagtt caatatgaaa
     4681 agaaaattaa tttctgtaaa cgtcgtttgt caagcctata aaagacctgt gtttgtgaaa
     4741 acaatttccc gttttaaagg gatgatagtc atttagttta tcctttatga ctttgttagc
     4801 gcgtcttacc gtacgttttt gtgactaact ttgtcagttt aattatcacc cttcaaccct
     4861 cccagttgtt aaaactgtct gcggcttgct gccttgtctt acaatcaaac caaaagacta
     4921 gaataaggag aaaggttatg acacatgttg tatctgaaat ttttaaagat ggcccggtag
     4981 acaggtttgg tttacgaggg gatcctgttt tttggaacta tttagaaaag cattttcaaa
     5041 aggtggctat gccatattcc gaaagaaaat tagaagagga tataagaacg atctatcaag
     5101 acttaactgg aaaagaattt agaatgggtg agatggctct tgttaaagac tttataagta
     5161 aatccggcgg catgtcatca ggatggctta gtgatgattt ttggcttaaa tcagctatac
     5221 cgcttctgaa aaaacgattg gcaaaatgga atgaaacttt ataaagactg caatttattg
     5281 attatgaaga atgataaatc aagcaatggt gtcataaaag acaaacggga tggcttatca
     5341 ttcttttgaa aacaatttga cattttcaaa gaaaagtcta aaatggaaaa cagtctgaag
     5401 aattgaggta atgaagaact ttgcggaaag aaaaaaatat gttgatatta ggttgggtag
     5461 cgacttttat gtctataatg atgtatgtgt cttatatccc tcagattatg aataatttag
     5521 caggaaataa gggggatttt atccaaccgt cagtggctgc tcttaactgc acactgtggg
     5581 taatttatgg tctttgtaaa gaaaagcgag accttccttt agctgccgcc aatatgccag
     5641 gcattgtttt tggcttgatt gcagcgatta cggcattagt ttagctttat aaaagcattt
     5701 atttcataaa ggttgtgaat tgagtctgtg aaatagagat ttctgtggaa cggctctttt
     5761 tttctgtcat ttatcaacct tttcctgaga tgatacctac ttaatcacaa tcaaatagac
     5821 gaggaaatgt gtcaaagtta atgagggcta agcaagaaaa gctgttagcg acggtctgtc
     5881 tagccacctt gctagctttc tttctcagtg ttattgattg ctcgaacgtg tatcgcaagg
     5941 tttcaagaaa attcactgac gctggatttt ctacgaattt tggataaaag tgttctaact
     6001 ttttattgtg tagtggtttt agtttaacgc agtgataaat tggaattttc gcgtcttgtt
     6061 ttttagtctc aaccctttaa agttcggtgt tctgccggag cttatctaat ctattttaag
     6121 gaaagcaaga cgacaaaatt gaatcgagct ttcattacga ttggccgaac tttttatacg
     6181 taattttata tatttacact attttgtgaa taattgcgca gcaatcagtt ttacccgcac
     6241 gagcgggggt gatcccagtg acaacaacga atcagataca gaaatcatgt tttacctata
     6301 catatagact tgtgatgtta gaccgattga aattgattct tttggataga aggaaatcaa
     6361 atatgtatat taagtggatg acaataaaag taaaatatta gataatagag attaagaatt
     6421 ataaagaatt ggaaaatgtt tagtcgtcaa acctaaaatc attataatga tacgaatatt
     6481 tttttgatca attttgtgat aatataaaga agctacatgc ttaccaatta tttcaatctg
     6541 atagaggtaa taatgaaact tttatatacc gacattccat acaacataac agagattttg
     6601 gccgaggaag cacaaatagc tgctaaggct ggcaagcggg tcttttatat tgctcccaac
     6661 tccttgtctt ttgagaagga gcgagctgtt ttggagaccc tgcctgagcg ggcttccttt
     6721 gctattacca ttacgcgttt tgagcaaatg gcacgctatt ttgttttaaa tgatattcat
     6781 cagggcgaaa ccattgatga taatggactt gccatggttt tttatcgtgc tttatccagt
     6841 ttttcagacc aagatttgcg tgtttttggg cgtcttaagc aagatgctca ttttatcaat
     6901 caattggtgg atttgtataa ggaactcaag gcttctaatc tgactgtctt agaattaaat
     6961 cagctaaatt cggctgaaaa gcaggaagat ttgattaaga tttttacaga ggttgaaacc
     7021 attttaagtg ctggccattt tgataatcaa agcaagattg ccttctttgc acaacagatc
     7081 aaatttggtc atttagatac ggctttgcag gatctgacaa ttgttgttga tggtttcaca
     7141 cgtttttctg ctgaagaaga aaacctgata ggactgttat atgaaaaagg tgttgacatt
     7201 atcattggga cttatattag tcaaaaagct tatcgttcaa ctttttcgaa tgggaatgtc
     7261 tatcaggcta gccttgattt cattcgtaac ttagctggta aatttcaaac caaaccagaa
     7321 tatgtggtat caaagcaaga agctttgcct gcctttacca aactttctca gctatttgaa
     7381 agttgtcatg atttttcgga cagtcagctg gtcttgacag ataaggacaa ggaacatgta
     7441 actatctggg atgtcattaa tcaaaaagaa gaagtggaac atgttgctaa gagcattcgc
     7501 cggaaactct atgaaggtca tcgttacaag gatattttgg tccttcttgg ggatgtggat
     7561 gcctataaac tgcagattgg caagattttt gataagtatg aaattcccta ttattttggc
     7621 aaagcggagt ccatgagttc gcacccgctg gttcattttg tggattcttt ggagcgggtt
     7681 aaacgttata attttcgtgc tgaggatgtc atgaatctgc tcaaatcagg cctatatggc
     7741 aaaatcaggc aaaatcagtt agataaattg gagcagtatg tcatttatgc tgatattaaa
     7801 ggaaaaacaa agttttttaa ggactttacg ctagataatc atgggcaatt tgatctaaaa
     7861 gccttaaata aactgcgggc agaagtcatg tcacctttac aagagctggt taaaatacag
     7921 gctcaaaagg gagacagtat cctgcaaaaa ttgaccaact ttttagaagc catttcttta
     7981 acgaataatt tttcaaaatt aatccaaggt gtcagtgaca ctgagcagga aaagaacgag
     8041 caagtttgga aaacttttac ggttatttta gagcaatttc atacgatttt tggacaagaa
     8101 aaaatgaagt tggctgattt tctggcactc ttacgcagcg gcatgctggc ggctgattat
     8161 cggacggttc ctgccagtgt tgatgttgtg acagttaagt cttatgattt ggtggagccc
     8221 catagcaata aatttgtttt tgctctggga atgacccagt ctcattttcc taaaattgtc
     8281 caaaataaga gtcttatttc ggatgaagaa cgtgcaaaaa tcaatgaagc aactcctgac
     8341 aatcgtcgtt ttgatattgt cactaaggaa aatctcaaga aaaatcattt caccgccctg
     8401 tcactcttca atgcggccac tcaggaattg gtcttaacct tgccgcagat tttaaacgag
     8461 gcagaggaca acacctcctc ctatttgctt gaattgcaag atatgggtgt gccagttgtc
     8521 gaaaaggggg gcaatcgttt agctgcggat ccagaagata ttggcaatta caaggcgctt
     8581 ttgtcgcgtg tgattgagct taaccgctct gctattgacc aagaattatc taaagaagag
     8641 cagacctttt ggtcagttgc tgttcgctat ttacgccaaa aattggcaaa agaaggactt
     8701 acgattcctg aagtgaacga taagatgcag accaagcagg tcgctgcaga ggttatggca
     8761 gcacgttttc caatagatca acctttaaat ctatcatcgt ctgccctgac aactttttac
     8821 aataaccagt atctctattt ccttcaatat atccttggtt tgcaagagct tgaaacgatt
     8881 catcctgatg ctagaaatca tgggacttat ttgcaccgcg tgtttgaatt ggttatgcaa
     8941 gatcaatcta ctgatgattt tgacagtaaa ttaaatcgtg ccattgatat aaccaaccat
     9001 gaggatagct ttcacttggt ttataatgaa gatgaggaaa gtcgctatgc tttgggtatt
     9061 ttagaagata ttgctcgtag tacagctacc gttttaaaag gggataatcc tgttcaggca
     9121 gaaagtgaag aagaagcctt tgagttaatg ctggatcagg ctgttaaaat cagaggggtt
     9181 attgatcgca ttgatcgctt gtcagatggc agtttaggaa ttgttgatta taaatcaagt
     9241 aaaaatacct ttgatctgca aaaattttac aatggactca gtccgcagtt agtgacttat
     9301 atagaagctc ttcggtcttg taaaaatttg aatgatacag ataagatttt tggagccatg
     9361 tatcttcata tgcaggaacc taaaactgat ttagccaata tgaaatccat cgaaaaaatt
     9421 ccggaaacgg ttcataagaa tttaagttat aagggactct ttttagaaga tgaaaaagca
     9481 catttggcta atgggaaata ccatttgcat gatgctgtct atagtcaaaa agaagttgat
     9541 ttgctgcttg attataataa aagactctat cgcagtgccg caaagcaaat cagaaaagga
     9601 aactttctca ttaaccccta cagtcaggat ggcaaatctg ttcagggaga acagctgaag
     9661 gctattacac attttgaagc agatcgccac atgccttatg ctcgtaaact ttatcagctg
     9721 ccacgcaaag aaaaacgtca gggtttcttg gcgttaatgc agtctaaaaa agaggaggaa
     9781 ggcaatgacc tttaaaccat ttttaacaga tcaagaaata gcttccttac aaattcaaga
     9841 agctcagtct gataagaaac aaaaacgaac gcctgagcaa attgaggcta tttacacttc
     9901 aggaaccaat attttggttt ctgcctctgc tggttcagga aaaacctttg tgatgattga
     9961 gcggattatg gataaaattc tgcgtggtgt aacgattgat cagcttttta tttccacctt
    10021 taccgttaag gctgctggtg agcttaagga gcgtttagaa aagaaaatca ccgagcaatt
    10081 gcgtttgaca aatgacactg ccctcaaaca atttctcagc gaacaactct tgggattgca
    10141 gactgcggat attggaacca tggatgcctt tacccaaaaa ttagtgatac agtacggcta
    10201 taccttggga atttcaccga attttcgaat tttacaagat aaaagcgagc aggatcttct
    10261 taaaaatgat gtctttgacg acctttttac tgattacaga actggcgatc aagcagagct
    10321 tttcactaag cttgttagga attttgctgg aaatcgaaaa gattcgagca attttagaca
    10381 aatcatttac aaaatttatg atttcagtca ggcaaccgat aatccccaaa gatggctttt
    10441 ggagaatttc ttaaaaggag ccaataccta taaggatttt tcagctattc ctgaacaaga
    10501 agtgaaagac tttttgaata ctttgcagga aactgctctc gctcttcgtg atgtgacgga
    10561 tttagaagat tacaagcaag taacggctaa aggaactcca acagcagctt atcaaaggca
    10621 ccttaaaatg attgagcagc tgcaggattg ggtcttgcat tttgacagtc tatatgggcg
    10681 agatggtctg gggaaattag caaatgacat tgcaacactc attccatctg gtaacgatgt
    10741 gacagtagca ggagttaaat atcctgtctt tcgcagtttg cacagtcgct taagaggact
    10801 aaaacacttg gaaacaattt tcaagtatca ggatcaaagt ctgcctttgt tgcaagtact
    10861 gcaatctttt acacttgatt tttcaaaaca atacctgcaa gcaaagatgc aggaaaatgc
    10921 ctttgagttt tcagacattg cacattttgc tatccagatt ttagaagaaa atgatgctat
    10981 tcgtcagctt tatatagata agtatcacga agtcatggtg gatgaatatc aggataataa
    11041 tcacacccaa gagcgcatgt tggaactttt atctaatggg cgcaatcgct tcatggtagg
    11101 agatattaag cagtctatct atcggtttcg tcaggcagat ccacagattt ttaatcaaaa
    11161 atttaaggat tttcaagaac atccagaaca tggaaaactc attctcttaa aagaaaactt
    11221 tcggagtcag tcagaagtct tagatgctac caatagtgtt tttacgcatc ttatggatga
    11281 aacggttgga gaaattctct acgatgatac ccatcagctt gtggctggca gttcagctca
    11341 gaaaattcct tatccgcaaa atgaaacaca agtcctcatc tatgatacaa aggatcagca
    11401 aaatcaagat cttgctgtag aagatgatag taatcaaatc agtctaggtg aggtcaaatt
    11461 ggttgctaag gagattattc gccttcataa tgaagaaaag gttcagtttg aagatattac
    11521 cttgcttgtc tcatcgcgga cacgcaatga tggtatcttg caaacatttg atgattatgg
    11581 cattcctttg gtgactgatg gtggtgaaca aaactatctg aaatcagtgg aagttatggt
    11641 catgttggat actctgcgtt ctattgataa tcctctcaat gattatgctc tagtagctct
    11701 tttgcgttca cctatgtttg cttttgatga ggatgacttg gctcgtctag ctctgcaaaa
    11761 tctaccagat caacacaaac aaaatcttta tgaaaagatg gagaatgcca gaaatggcca
    11821 aggccagcaa gttcagttga tcacagaagc attgtctgcc aaattggatg ctttctttga
    11881 aactttcctc agttggcgtg agtttagtct cttaaattcg ctctatgatt tgatttggaa
    11941 aatttataat gataagtttt actatgatta tgtgggaagt ttaccaaaat ctgagcagcg
    12001 ccaagccaat ctttatgctc tagccctgcg tgccgataac tttgagaaaa caggttttaa
    12061 ggggttgtcg cgcttcattc gtatgattga caaaattcta gaaaatcaaa atgacttggc
    12121 tgatgttgaa gtcgctttac ctaaaaatgc agtgacgctg atgacgattc ataagagtaa
    12181 gggattggaa tttaaatatg tctttattct taatattgat aaaaaattta gcattcaaga
    12241 tatgacatca cccttaatct tatcgcggca aaacggtgtt ggtatcaagt atattgctga
    12301 tatgaaagaa gaactagagg aaaaattatt gccgacagtt aaagtcagca tggatactct
    12361 tccttatcaa ctgaataagc gtgagcttcg cctggcaacc ctatctgaac aaatgcgatt
    12421 gctttatgtt gccatgacac gatctgaaaa gaaactttac ttggtcggaa aaggcagtca
    12481 ggaaaaatta ggggatcagt atgatggcaa atcagaaaac aatcatttgc cagtagctga
    12541 tcgtgaacac tatttgactt ttcaggattg gcttttggcg attgaagctg cttatgctgc
    12601 cgatgaactt cattttaaaa caagttttat aacggatgaa gacttaacag aagataaaat
    12661 gggaagttta gaagcagagc aggcttatga tgcggataat cttaaggata atcggcaatc
    12721 agatgatatt gcgcgtgctt tagatatgtt agaagcagtt gaaaaattaa atcagcacta
    12781 taaggctgct atccatttac caactgttcg tacgccaagt cagatcaaaa aattttatga
    12841 gcctgttatg gaaacagaag gtgtagaggt gatgcaaact tcctatc
//
