LOCUS       NZ_JAQCYD010000003     27033 bp    DNA     linear   CON 23-FEB-2024
DEFINITION  Streptococcus mutans strain AF36-21BH AF36-21BH.Scaf3, whole genome
            shotgun sequence.
ACCESSION   NZ_JAQCYD010000003
VERSION     NZ_JAQCYD010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 218156)
  AUTHORS   Lin,X., Hu,T., Chen,J., Liang,H., Zhou,J., Wu,Z., Ye,C., Jin,X.,
            Xu,X., Zhang,W., Jing,X., Yang,T., Wang,J., Yang,H., Kristiansen,K.,
            Xiao,L. and Zou,Y.
  TITLE     The genomic landscape of reference genomes of cultivated human gut
            bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 218156)
  AUTHORS   Zou,Y., Lin,X. and Hu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2022) BGI Reaserch, BGI-Shenzhen, Beishan
            Industrial Zone, Shenzhen 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: MGI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/23/2024 01:23:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,988
            CDSs (total)                      :: 1,943
            Genes (coding)                    :: 1,890
            CDSs (with protein)               :: 1,890
            Genes (RNA)                       :: 45
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 38
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 53
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 33 of 53
            Pseudo Genes (incomplete)         :: 28 of 53
            Pseudo Genes (internal stop)      :: 23 of 53
            Pseudo Genes (multiple problems)  :: 22 of 53
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:29:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 143957
            Orig. end                         :: 170990
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQCYD010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27033
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..27033
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27033
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17033](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17033)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(352..1041)
                     /locus_tag="PGX70_RS05480"
     CDS             complement(352..1041)
                     /EC_number="7.4.2.11"
                     /GO_function="GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0048473 - D-methionine transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019323372.1"
                     /locus_tag="PGX70_RS05480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methionine ABC transporter permease"
                     /protein_id="WP_002262134.1"
                     /transl_table=11
                     /translation="MHFIQTYLPNAYELGLTGDAGWLTAILNTLYMTIVPFVIGGGVGL
                     VFGLLLVLMGPEGVIENKVVCWIIDKVTSVFRAIPFVILIAVLAPLTMLLMQTNLGATA
                     ALVPLSFATFPFFARQVQVVFSELDRGVIEAAQASGATFWDIVKVYLSEGFPDLIRVST
                     VTLISLVGETAMAGAIGAGGLGNVAISYGYNRFNNDVTWVATLLILLLIFTIQFIGDTL
                     TRKVSHR"
     gene            complement(1043..2107)
                     /locus_tag="PGX70_RS05485"
     CDS             complement(1043..2107)
                     /EC_number="7.4.2.11"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0033232 - ABC-type D-methionine
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0048473 - D-methionine transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314924.1"
                     /locus_tag="PGX70_RS05485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="WP_002280241.1"
                     /transl_table=11
                     /translation="MSKAIIKLDHIDITFHQKKRTIEAVKGVTVHINQGDIYGIVGYSG
                     AGKSTLVRVINLLQTPTKGKITVDQDVIFENGEKRLSSQELRKKRHEIGMIFQHFNLMA
                     QKTARQNVAFALRHSNLSAAEKESKVTELLELVGLTDRAENYPSQLSGGQKQRVAIARA
                     LANDPKILISDEATSALDPKTTKQILALLQDLNKKLGLTVVMITHEMQIVKDICNRVAV
                     MQEGSLIEEGSVLDIFSNPREDLTKDFIKTATGIEEALIKIKQQEIVKNLPANAALVQL
                     KYAGKTTDEPILNNLYKKYQVTANILYGNIEILEKTPVGEMIVILEGAATNIEQALNDL
                     THSDLTVTVLKRGV"
     gene            complement(2100..3473)
                     /locus_tag="PGX70_RS05490"
     CDS             complement(2100..3473)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002307175.1"
                     /locus_tag="PGX70_RS05490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_151416437.1"
                     /transl_table=11
                     /translation="MAFSSEQEQIAKFWQDEVAQHYFEVLRTLISKKSIFAQQIGLQDV
                     AGYLGEIFANVGAEVTIDETYTAPFVIAKFKSSKPQAKTIIFYNHYDTVPADNDQIWTD
                     NPFKLTLRRGYMYGRGVDDDKGHITARLTAVRKYIREVGDLPVNVTFIIEGAEESASTD
                     LDKYLKKYTDSLLPADVLIWEQGVKNSQGQLEITGGNKGIITFNLSVSSAEVDIHSKYG
                     AVIESAAWYLLNAISSMRADDGQILIDGIYDQVLEPNERELDLVERYALENSEGLRKVY
                     GLKLPTLKKERRDFLKTYFFEPALSIEGLSSGYQGQGVKTILPSAASAKMEMRLVPGLS
                     PQYVFEKINSHLRKLGFEHVKVTYTLGEESYRSDMSAPAILTIIDLAKQFYEAGVSVLP
                     TAAGTGPMHTVYDALGIPMLAFGLGNPNSRDHGGDENVNLADYYTHIELIKELIRSYE"
     gene            complement(3668..4510)
                     /locus_tag="PGX70_RS05495"
     CDS             complement(3668..4510)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002295595.1"
                     /locus_tag="PGX70_RS05495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_002267930.1"
                     /transl_table=11
                     /translation="MKLKKILGLLGLALAAAFVLTACGQKNDKNTLTVGVMTMTDSDKE
                     RWDKIEELLKKENIKLKFKEFTDYSQPNKALKNGEIDINSFQHYNFLNNWNKENKGDLV
                     TVAETYISPINLFSGTENGKAKYSSAKEIPDGGQIAIPNDATNESRALYVLQDAGLIKL
                     NVSGDELATVKNIKSNPKNLDIKEVDASQTARNLASVDAAVVNNSYAVPAKIDFKTSLY
                     KEKVNEGSKQWINIIAAQKNWKKSKKAAAIKKLIKAYHTDAVKKVIKKTAKGVDEPVW"
     gene            complement(4677..5480)
                     /locus_tag="PGX70_RS05500"
     CDS             complement(4677..5480)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804427.1"
                     /locus_tag="PGX70_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_002271514.1"
                     /transl_table=11
                     /translation="MKLKHILRIGAVAFASILLLTACGSKSSKKTVTLATVGTTNPFSY
                     EKKGKLTGYDIEVAKEVFKASDKYDVKYQKTEWTSIFSGLDSDKYQIGANNISYTKERA
                     NKYLYSNPTASNPLVLVVPKDSDIKSYNDIAGHSTQVVQGNTTVPMLQKFNKNHENNQV
                     KLNFTSEDLAHQIRNVSDGKYDFKIFEKISAETIIKEQGLDNLKVIDLPSDQKPYVYFI
                     FAQDQKDLQKFVNKRLKKLYENGTLEKLSKKYLGGSYLPDKKDMK"
     gene            complement(5597..>5865)
                     /locus_tag="PGX70_RS05505"
                     /pseudo=""
     CDS             complement(5597..>5865)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014608093.1"
                     /locus_tag="PGX70_RS05505"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="amidohydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LTCSSQLTPLFFYNSKKFVEVLEVESSAGGEDFRVHQKKFLASLR
                     DQMAMRMQLTGTIMILS"
     gene            5981..>7209
                     /locus_tag="PGX70_RS05510"
                     /pseudo=""
     CDS             5981..>7209
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057303.1"
                     /locus_tag="PGX70_RS05510"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="ISL3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEPINNTTLLIGIKDKHISLNEAIQRDTHTKIIATLDYHPPNGNT
                     ARENRLSMTSRNLLKFLSSKLVVLLVLSA"
     gene            complement(7365..7553)
                     /locus_tag="PGX70_RS05515"
     CDS             complement(7365..7553)
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268652.1"
                     /locus_tag="PGX70_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lichenicidin alpha family lanthipeptide"
                     /protein_id="WP_002268652.1"
                     /sec_met_domain="mature_ha (E-value: 1.1e-15, bitscore:
                     50.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEIQKAGLQEELSILMDDANNLEQLTAGIGTTVVNSTFSIVLGN
                     KGYICTVTVECMRNCSK"
     CDS_motif       complement(7467..7553)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKEIQKAGLQEELSILMDDANNLEQLTAG"
                     /locus_tag="PGX70_RS05515_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7365..7466)
                     /prepeptide="core"
                     /locus_tag="PGX70_RS05515_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.00"
                     /molecular_weight="3395.0"
                     /monoisotopic_mass="3392.7"
                     /core_sequence="IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKEIQKAGLQEELSILMDDANNLEQLTAG"
                     /leader_location="[7466:7553](-)"
                     /alternative_weights="3413.0"
                     /alternative_weights="3431.0"
                     /alternative_weights="3449.0"
                     /alternative_weights="3467.0"
                     /alternative_weights="3485.1"
     gene            complement(7581..7769)
                     /locus_tag="PGX70_RS05520"
     CDS             complement(7581..7769)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268653.1"
                     /locus_tag="PGX70_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002268653.1"
                     /transl_table=11
                     /translation="MKSNLLKINNVTEMEKNMVTLIKDEDMELAGGSTPACAIGVVGIT
                     VAVTGISTACTSRCINK"
     CDS_motif       complement(7674..7769)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKSNLLKINNVTEMEKNMVTLIKDEDMELAGG"
                     /locus_tag="PGX70_RS05520_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7581..7673)
                     /prepeptide="core"
                     /locus_tag="PGX70_RS05520_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.60"
                     /molecular_weight="2750.2"
                     /monoisotopic_mass="2748.5"
                     /core_sequence="STPACAIGVVGITVAVTGISTACTSRCINK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSNLLKINNVTEMEKNMVTLIKDEDMELAGG"
                     /leader_location="[7673:7769](-)"
                     /alternative_weights="2768.3"
                     /alternative_weights="2786.3"
                     /alternative_weights="2804.3"
                     /alternative_weights="2822.3"
                     /alternative_weights="2840.3"
     gene            complement(7868..9964)
                     /locus_tag="PGX70_RS05525"
     CDS             complement(7868..9964)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019781436.1"
                     /locus_tag="PGX70_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_063330941.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.7e-29, bitscore:
                     96.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQTECGLCVAVMLMEYYDVRITLNDIPKEFSAGRDGTRIRGLKK
                     IFDHFGFSMNMFKVTDRLSEIKNSSLPGIAYRIGGHFVVVESISSNEVIILDPAFGRTK
                     ISKDELDNDYKNLILKITPNENFKTVNTRGQEFSLIKEAVFFNKKLVVQVLIAAVIVYS
                     LTLVAPLLLKGLVDNFLVSKQIDTTIWALSIGTIASSLVYFVVNRVKQITSIRLSISVD
                     KFLSKKVVDKLFKNKFEFYLNRTSSDIQYRLVLLKNLKTIISDIIIQTFLDIGSMVIIL
                     IYIMNLQPLYAVFLAFITLLVLSMSRFMREKMLLYKNKELATDSKLQVFQYDIFRAIFD
                     VKVLGLSSKKHRSWHRYYEDYIKSHEKNQRFITLYQNILAYITLYVPIFIPILGIWISG
                     LAHSNQVGTIISLQSITGTYISGLISIAQLSDNITTAKSYLIRIDDILLQEDEAVRNRT
                     IDFKGNIRVNNLSFVYPGAEDKTLDDISFSINEGESVAIVGESGSGKSTLFYILLGAYD
                     NYEGDIYFEGLDLKILNKDALREQIGVVPQDALLFNGSIKENLVEDFEVADNDIYDALK
                     KVTLLDFVYSLPMGINTVVSENGFNFSGGQRQRLALARAILNQKSMLFLDEATSALDNI
                     TEHQIVEYLSEDSKTKIVIAHRLSTIKNSDKIIVLKDGQVSEVGDHHSLMAQKGEYYRM
                     YSGK"
     gene            complement(10001..12616)
                     /locus_tag="PGX70_RS05530"
     CDS             complement(10001..12616)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002280552.1"
                     /locus_tag="PGX70_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_151416439.1"
                     /sec_met_domain="DUF4135 (E-value: 9.8e-48, bitscore:
                     156.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.4e-16, bitscore:
                     51.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENIRNSAYPSIEGKFENYFSHYISKIYEQLLSIDSKGLFSSQND
                     QEKCYYALIEGILKNISSVAISSLIDYYQEERAINPNLSYKDYNENLQKDRYFQEFHQI
                     YPTVKDNCEVVICNYIQRTKEVFSLLQNYQVEIRNVASLKESESLSLSNLNIFEGDFHI
                     NTFVAILTLNEKRILIKKRPNLGDRLLRIFQKYFDKENIKLPIANTIFLDDDLCLQEYI
                     KSDSAVLNSIELQNFYYKFGIMTAIFTILGSKDLHSENIISTKYGPYFIDLEAAITDTL
                     NREKLDSLLTETYLFNSKEKRLVYGSLDLSAFSGGDITTRRYGVIHKGQDDINIGVYSY
                     TEKHSNIPQDINGAKVNPEEYSADVLKGFDTGIRIFLKYKERLIQKLELIESYDYRVVL
                     RNTAFYGKYLDDLNLPMYTKSKEKSEKYIHLLRKHSKRDKKIVDKEMACLKQQAIPYFL
                     ISEVTDNKIIKDNLIKRIEGLSLSDLNKEKYYLQLILGLDVPIEGRSHYLDNGNKVDNE
                     LQAFESFCSNDVGFKFGVIDHTVQNTLLHYCNDIYTFGASLLFLARYCKNSKLREKIIT
                     TVRNGGTSEGLSGLIGRQSSYLLYHYFNLESEKQNYTSSKDIVHEKDIVDFSTYGSAIL
                     VLNYLYKETSNKAYLDDIKLLGEIYLKTYTKRNLTGLFHGYAGDILVLSVLRQYIEHQT
                     IDKDILDLIQLENSNFNKVSNNWNDTRHNISNTEDLCALSYGAVGILFSRHLLYRSSNL
                     YKKLKDIVMTDLFKALNCILVRNRSDYVDDSLVNGYAGALVVLKIILQSGLLNNHYSKL
                     IKVKTYIEEGEKLLENTQWRYEQFNNLLNPSFFSGRLGTAFTLWFISQNDFYIEKFLGV
                     "
     gene            complement(12616..13332)
                     /locus_tag="PGX70_RS05535"
     CDS             complement(12616..13332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268656.1"
                     /locus_tag="PGX70_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_002280551.1"
                     /transl_table=11
                     /translation="MSNKWATVLFVRPIIMKFSVFIFLMLSLLLGGGIIYSIENLKGPF
                     QVYNIYSVFSTVSNFLLMYAAINAFGREFRYKTINHLRISGRSSIEIILRKLLAVEFLA
                     ILTSLVSFVEVAFYKIYFNHPQIDLFEIFNHLVPAYLVYALFLFSLGSIITLVLKNSLY
                     SFITLFLTLRLGVTIMNVMNNFESTADLTKYIPLSFVENAFSFAKYTPEQYVVTIVWSV
                     ALMALLPVIYRKWGYA"
     gene            complement(13322..14146)
                     /locus_tag="PGX70_RS05540"
     CDS             complement(13322..14146)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002280550.1"
                     /locus_tag="PGX70_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002280550.1"
                     /transl_table=11
                     /translation="MRILDIQNLNFKYGKDYVLKNINLTLEQGDILGLVGENGAGKSTL
                     MKLISGIIPNYEGDIKIQAHNVGTLIEHPSLYADMTVLSNLKFYCRLFGKSYGVIDDYK
                     YVLQVDSYLHKKVSKLSLGMKQRVGLFIALIASEEFILLDEPTNGLDPIGIKNLLDLIK
                     KLSSEKGITFIISSHILQNLEQICNKAVLLRNHTISSLDAKKHMKYKIYHPDLSQSELI
                     CLLEDNGFDYEQNGRDIIVRDIDAIEEMLQREKNITIQKEKISLSEVYFDEQ"
     gene            complement(14157..17033)
                     /gene="lanM"
                     /locus_tag="PGX70_RS05545"
     CDS             complement(14157..17033)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002280549.1"
                     /locus_tag="PGX70_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_063330939.1"
                     /sec_met_domain="DUF4135 (E-value: 3.5e-67, bitscore:
                     220.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.1e-73, bitscore:
                     240.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METRTDNIFIKLSDNSNIEKLYKKFGMNLLEDINASIDEFEVYES
                     WNRFHLLGSNTFSNLYLSFLEPYLLEIRNQLQKYDDNFQSDTIERTITENMLENISSLS
                     EGVWIAEMRNINKNQTEYLVYLNQDYKNLAEVVKKYPYWYFSIISFIRDTTKYLLEFLS
                     HLIQDKALVANQFLEADGMITDIKLSMGDRHRGTFVIKVESKFGNYFYKPRRSKLDTLF
                     KEVIDKIGEQDGILKMKAPKIIDQGSYSWAEEIRYIPLQSKNENERYYIRLGQLLAITY
                     ILNGSDLHYENIISCGEFPVAIDVETLLTSRLRFKKQTTPKMLQEDNINYLEDSVSNLI
                     ILPTIVKSNGDFYDLSPLKIYSGELPNTLAETWKKSNHLIQKNELKDVIGFIQRGFINI
                     YNEVLKDKERYKEYFNRLFNNAPIRYLNRETHDYSQILRLLKNPVCLFHFKYAFAVSMK
                     LLSEEIQEEEVLEYKELLKFNIPYFELDTDSTDLLLFDDKRIKNYFIETPLESLEHKLN
                     ILCEEDLERQLRLITQMLTVVSAEFDVKEINEVTIHEGESLQKQRAQTVEQMIATVFEN
                     KLINPLTKQYFWITPELEGDNNRSFYQIHENPDSYYSGSVGILRCLLLLEKSGYKDLPI
                     NKLISDIEIDIDAIINYGTVDTSIGAYNGIAQYLRYYAYIYKNNNFSVLSLKRIHYLLD
                     LIENGFKNDEKLDILDGTAGVILTLIEIFQLDLSDCLNNRVIKLVEKCRLHLIDSIIYD
                     KGEAYFPIAQEKNRYFTGFAHGSSGITLAIYRASKLLNIDDYTLIRSLLKTERRLFDKT
                     NQMWFKDNNRNSYSWGWCHGIPGILLSRLELIKHGYQDDYIIEEAYELYEIAIKKSLGV
                     NLTFCHGDLGNIVICKYAEVMLDIENSKVDKYIQEIFPYLTNATRYHIRGTETIGVMHG
                     LVGVATFLDSTICDNYLRFLDILKITSD"
     misc_feature    17265..17276
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.02"
                     /tool="antismash"
     misc_feature    17296..17309
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.93"
                     /tool="antismash"
     gene            complement(17750..20251)
                     /gene="leuS"
                     /locus_tag="PGX70_RS05550"
     CDS             complement(17750..20251)
                     /EC_number="6.1.1.4"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004823 - leucine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006429 - leucyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677748.1"
                     /locus_tag="PGX70_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="leucine--tRNA ligase"
                     /protein_id="WP_226711745.1"
                     /transl_table=11
                     /translation="MVYYNHKAIENKWQKFWEDNHTFKTGTASSKPKFYALDMFPYPSG
                     AGLHVGHPEGYTATDILSRFKRAQGYSVLHPMGWDAFGLPAEQYAMDTGHDPADFTAQN
                     IATFKRQIKSLGFSYDWDREINTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELG
                     TAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEDLDWPESIKDMQRN
                     WIGKSTGANVTFKVKDTDEEFTVFTTRPDTLFGATYAVLAPEHDLVDIITTAGQAQAVA
                     DYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGTGAIMAV
                     PAHDERDWEFAKQFNLDIIPVLKGGNVAEAAYTDDGLHINSGFLNGLDKAAAIDKMVTW
                     LETEGVGNKKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALPENELPLVLPVTKDIK
                     PSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYFLRYIDPHNDQKLADED
                     LLKQWLPVDVYVGGAEHAVLHLLYARFWHKFLYDLSVVPTKEPFQKLFNQGMILGTSYR
                     DHRGALVATDKVEKRDGSFFNIETDEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRV
                     YEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEIAAKNNGHLDKVYNEVVKTVTE
                     HLEAMRFNTAISQLMIFVNAANKEEQLFLDYAKGFIQLLAPFAPHLAEELWQFLTQSGQ
                     SITYVAWPSYDESKLVEDEIEIVLQIKGKVRAKVVVSKDSSREDLEKIALANDKIQAEI
                     AGKDIVKVIAVPNKLVNIVVK"
     misc_feature    complement(20209..20227)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.83"
                     /tool="antismash"
     misc_feature    20531..20547
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.52"
                     /tool="antismash"
     gene            20651..21415
                     /locus_tag="PGX70_RS05555"
     CDS             20651..21415
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305906.1"
                     /locus_tag="PGX70_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyphosphate polymerase domain-containing
                     protein"
                     /protein_id="WP_002265135.1"
                     /transl_table=11
                     /translation="MLNETIQKEFQRKEIKYLIEADTFEQLQKEFKDYLTPDRFTHSSI
                     TNIYFDNPDFQLIKDSINHRHASEKIRMRTYDPKPTQKSQAFLEIKKKEYQGEQEIGYK
                     YRLTSTPLSLCNYVQQGIIDNNIKQDDRANHELAILRERYKKLVPKMFIHYERFSLRGI
                     ENPKLRVTFDRNVIYRHENVNLTSGFNGYPLLKNNQIVMEVKVKNGLPAWMEKIFHKHQ
                     LIPQSFSKYTTAYLKAYGLTPEDIREEPTSIA"
     gene            21408..22097
                     /locus_tag="PGX70_RS05560"
     CDS             21408..22097
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265438.1"
                     /locus_tag="PGX70_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4956 domain-containing protein"
                     /protein_id="WP_151416442.1"
                     /transl_table=11
                     /translation="MLNQIFNSVFSNRDITISPSMFALSILISLLLGLLLAKIYKYKTI
                     YTKEFIITLATLPVLISMIIFLVNGNLGTSVAVAGTFGLIRFRSAAGGAKEILYIFFAT
                     AVGIATGMGFLVLAILFTLTLTLVLWLYENSGFSQVSTSRRQATFIVPNNEIDYIPILE
                     KILNKTCREINLISVKNINKNNTIQMEYHLDLKPEMNDIGLINSIMTYNPDIEVTLDTS
                     AKKKKIL"
     gene            complement(22314..22850)
                     /gene="nusG"
                     /locus_tag="PGX70_RS05565"
     CDS             complement(22314..22850)
                     /GO_process="GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /gene="nusG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262142.1"
                     /locus_tag="PGX70_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcription termination/antitermination protein
                     NusG"
                     /protein_id="WP_002262142.1"
                     /transl_table=11
                     /translation="MDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPT
                     QTVNVEKNGKTKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPL
                     LEEEIRSILLSMGQTVDIIDTNIKEGDVVQIIDGAFVGQEGRVVEIENNKVKIMINMFG
                     AETQAELELYQIAEL"
     gene            complement(23008..23184)
                     /gene="secE"
                     /locus_tag="PGX70_RS05570"
     CDS             complement(23008..23184)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262143.1"
                     /locus_tag="PGX70_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="preprotein translocase subunit SecE"
                     /protein_id="WP_002262143.1"
                     /transl_table=11
                     /translation="MKFIGGVFSVLKHTTWPTRKQSWHDFISILEYSAFFALVIFIFDK
                     LLTLGLAELLKRF"
     gene            complement(23196..23348)
                     /gene="rpmG"
                     /locus_tag="PGX70_RS05575"
     CDS             complement(23196..23348)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /locus_tag="PGX70_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_002262144.1"
                     /transl_table=11
                     /translation="MAQKKASLACVECGSRNYSIGVSGNPKPNRLEVNKFCKYCKKYTL
                     HKETR"
     gene            complement(23399..25675)
                     /gene="pbp2a"
                     /locus_tag="PGX70_RS05580"
     CDS             complement(23399..25675)
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pbp2a"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803810.1"
                     /locus_tag="PGX70_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="penicillin-binding protein PBP2A"
                     /protein_id="WP_002280243.1"
                     /transl_table=11
                     /translation="MSILELLKKKFFPNKNIDHQDSKEVENGMPQNLDNQASQASDNHY
                     HRRYAQEEASKFSNILSKIGLSKNGLVRRYWRRYHVGKILLIAVGIFVLLTGSYLFYLA
                     KTTKVSDLKQALKATTVIYDKNEKQAGTLYGQKGTYVELDAISDDLENAVISTEDRSFY
                     KNSGINYKRMLLAIVTLGYSGGGSTITQQLAKNAFLTQEQTVKRKAREFFLALELTKKY
                     SKKEILTMYLNNAYFGNGVWGVEDASQKYFGTSASRLTLDEAATLAGMLKGPGIYNPLY
                     SIENATSRRDTVLQNMVAAGKISQKQANEAKKVGMGNRISDTYVAKTDDYQYPSYFDAV
                     ISEASSVYGISEKDIVNNGYRIYTELDQNYQTGMQQTFDEESLFPVSTYDNTSAQAASV
                     ALDPKTGGVRGLVGRVNSTKNVTFRNYNYATQSNRSPGSTIKPLAVYTPAIASGWSMDK
                     LLPNTSRDFDGYKPNNYGNIETEDIPMYQALANSYNIPAVYTLDKLGINKAFSYGKRFG
                     LNMDAAKKELGVALGGSVTTNPLEMAQAYATFANGGVMPTAHLISRIETASGEILKKFT
                     PNDKRVISKSVADKMTSMMLGTFSNGTGVNANAYGYTLAGKTGTTETNFDSNLASDQWV
                     IGYTPDVVISQWLGFNKTDENHYLNDSSSGTASNIFSTQASYILPYTKGTEFKVKNAYF
                     QDGIKSTYDSDDTSDETNSNSQNIIDGIREKAQNATDSIKKKVDDSNIIDKAKKVWDSV
                     VNYFE"
     gene            25719..26585
                     /locus_tag="PGX70_RS05585"
     CDS             25719..26585
                     /EC_number="5.4.99.-"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279: pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299283.1"
                     /locus_tag="PGX70_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RluA family pseudouridine synthase"
                     /protein_id="WP_002266909.1"
                     /transl_table=11
                     /translation="MTFTVKIINPYPIGTVKELLEEHFLIPRKIRHFLRIKKNVTVNSQ
                     AVNWQSLVRRGDIIQLNFDNTDYPIKKIPMGNKTLIDCLYQDEHLIIVNKIEGMKTHAN
                     DPNEIALLNHVSAYVGQTCYVVHRLDMKTSGTVMFAKNPFILPILNRLLENKSIKREYW
                     ALAQGQFSERAIIYREPIGRDRHDRRKRVVDHKHGQTAITQVSLLKHFPNNTSLIKCQL
                     QTGRTHQIRVHLAYHDHAIVGDPLYSQQTAGRLMLHAHQLTFTHPLTLEKIKVEAPSAT
                     FEKGLPK"
ORIGIN
        1 ctgtattgta aaattggcct tttcgtttag tcgctacaga tccagcaact aaagtaactc
       61 catgtttctc agcaaattga ctaagccaag gacgactgac tttcccatct tcatcagcaa
      121 ttctttctaa tttatccaac gcataaccac tgttccataa ttctggtaaa acaatgacac
      181 ccggctcttc taagagtgct tcttgtaaaa gattttggac gtttgcctga ttaacatgag
      241 actgaccatc ttttatatct aattgcaaaa gactaatttt caaaaaaaca cctcctcaag
      301 caaggtcaca agaaacaaaa tcgtaatctc aattttttcc taccttaagt attaacgatg
      361 acttactttt cgagttagcg tatctccaat aaattggatt gtaaaaataa gcaaaagaat
      421 aagtaaagtt gcaacccaag tgacatcatt attaaaacga ttatagccgt aagaaatagc
      481 aacattccca agtcccccag ctccgattgc tccggccata gccgtttcac caacaagaga
      541 aatcaaggtt accgttgaga cacgaataag atctggaaaa ccttcactga gatagacctt
      601 tacaatatcc caaaaggtag ctccagaagc ttgtgctgcc tcaataacac cgcgatccaa
      661 ttcagaaaag acaacctgta cttgccgtgc aaagaaagga aaagtcgcaa aagataaagg
      721 aaccaaggct gctgtcgcac ctaaattcgt ttgcatcaaa agcatggtta atggtgctaa
      781 gacagcaatc aaaataacaa aaggaatagc gcggaaaaca gatgttactt tatcaatgat
      841 ccaacaaaca accttatttt caataacacc ttcaggtccc atcaatacta agagaagacc
      901 aaaaaccaga ccaacgcctc ctccaataac aaaaggaaca atagtcatat aaagtgtatt
      961 cagaattgct gttaaccaac cagcatctcc tgtcaaacca agctcataag cattgggtaa
     1021 ataggtttga ataaaatgca ttttaaactc ctctcttcaa aaccgttact gttaaatctg
     1081 aatgtgttaa atcattaagt gcttgctcaa tattagtagc tgcgccctct aaaataacaa
     1141 tcatctcacc aacaggtgtc ttttctaaaa tttctatatt gccatacaga atattagcag
     1201 tgacttgata ttttttataa aggttattta aaataggctc atccgtggtt ttacccgcgt
     1261 attttaactg caccaaagca gcattagccg gcaagttttt aacgatttct tgctgtttaa
     1321 tctttatcaa agcttcttca attcccgttg ctgttttgat gaagtctttg gttaagtcct
     1381 ctctaggatt tgaaaaaata tctaaaacag atccttcttc aattagagaa ccttcctgca
     1441 tgacagccac acgattgcaa atatctttaa caatttgcat ctcatgagta atcatgacaa
     1501 cagtcaatcc caatttttta tttaaatctt gtaaaagtgc taaaatttgc ttggttgttt
     1561 tgggatctaa ggccgaagta gcttcatctg aaatcagaat tttaggatca ttagcaagag
     1621 ctcgagcaat cgcgacacgt tgtttttgac cgccagaaag ctgtgaaggg tagttctctg
     1681 cacgatcagt taagcccacc aattctaata attctgttac tttgctttct ttttccgctg
     1741 cactaagatt ggaatgacgc aaggcaaaag caacattttg gcgcgcagtc ttctgagcca
     1801 ttaaattaaa atgctggaaa atcataccaa tttcatgacg cttctttctg agttcctgac
     1861 tggataaccg cttttcacca ttttcaaaaa tcacatcttg atctactgta atttttcctt
     1921 ttgttggggt ctgcaaaaga ttaatcacac gaacaagagt ggacttaccg gcgccagaat
     1981 aaccaacaat accataaata tcaccttgat taatatgtac tgtgacacct ttaaccgctt
     2041 caatagttcg cttcttttgg tgaaaagtga tatcaatatg gtcaagtttt ataatcgctt
     2101 tactcataac ttctaattaa ctccttaatt aattcaatat gggtataata gtctgctaaa
     2161 ttaacatttt catcaccacc gtgatcgcga ctattgggat tgccaagtcc aaaagctaac
     2221 ataggaatgc ccaaagcatc ataaaccgta tgcataggac ctgtaccagc agcagtgggc
     2281 agaacagata cgccagcttc ataaaattgc ttagccaagt caataatggt caaaatagcc
     2341 ggagcactca tatcactgcg ataagattct tcgcctaagg tataggttac cttaacatgt
     2401 tcaaagccta attttctcaa atgactatta atcttttcaa aaacgtactg gggactgaga
     2461 ccgggaacta aacgcatttc catcttagca ctggcagcag aaggcagaat tgttttcaca
     2521 ccttgccctt gataaccaga agaaagtcct tctatggata aggcgggttc aaaaaaatag
     2581 gttttaagaa aatcacgacg ctcttttttt aaagttggta attttaaacc ataaactttg
     2641 cgcaaacctt cactattttc aagagcataa cgctctacta aatccaattc acgctcattg
     2701 ggctccaaga cctgatcata aataccatcg attaaaatct gaccatcatc tgctcgcata
     2761 ctggaaattg catttaagag ataccatgct gccgattcaa taaccgcacc atattttgag
     2821 tgaatatcaa cctctgcact ggatacagaa agattaaaag taataatacc tttattacca
     2881 cctgtaattt ctaactgacc ctgactattt ttaacacctt gttcccaaat caaaacatct
     2941 gcaggaagca aactatccgt atattttttt aaatacttgt caagatctgt tgaagcagat
     3001 tcttcagctc cttctattat aaaagtaaca ttaacaggaa gatccccaac ctcacgaata
     3061 tactttcgaa cagctgtcaa acgagctgta atatgccctt tgtcatcatc aacaccacgg
     3121 ccatacatat aacctcttct taaggtcagt ttaaagggat tatctgtcca aatctgatca
     3181 ttatctgcag gtactgtatc ataatggtta taaaaaataa tggttttagc ctgaggtttg
     3241 gaacttttaa atttagcaat aacaaaagga gccgtatagg tttcatcaat tgtcacttca
     3301 gcaccgacat tggcaaaaat ttcgcccaaa tagcctgcaa catcctgcag gcctatctgt
     3361 tgtgcaaaaa tagatttttt ggaaattaag gtccgtaaaa cctcaaaata atgctgagca
     3421 acttcatcct gccaaaattt agcaatttgc tcttgttcac ttgaaaatgc catttttctc
     3481 cttttatatg actaagaggt gagacaaaat cattatctta tataatttta tcgctctcat
     3541 atcgcagagc taaggaaaaa accactcact gatgagtttt tccacctctg aacttaattg
     3601 tcattatctt aaaataagtc tgggtagctt ttctcccaga ctcattgtta tttgccttta
     3661 cccactctta ccaaacaggt tcatcaacgc ctttggcagt ctttttaata acctttttaa
     3721 cagcatctgt atgataagcc ttaatcaatt tcttaatcgc tgctgccttc tttgattttt
     3781 tccaattctt ttgagctgca atgatattaa tccattgttt agagccttcg ttcacttttt
     3841 ctttataaag agaagttttg aaatcaattt ttgctggaac agcgtaactg ttattaacaa
     3901 cagcagcatc aacggatgct aaattacgag ctgtttgact ggcatctact tctttaatat
     3961 caagattttt gggatttgac ttaatatttt taacggtagc caattcatca ccagaaacat
     4021 ttaatttaat taagccagca tcttgaagaa cgtaaagagc gcggctttcg ttagtagcat
     4081 cattaggaat agcaatttga ccgccatctg gaatttcctt agcactactg tattttgcct
     4141 taccattttc tgtgcctgag aaaagattaa tcggactgat atatgtctca gctacagtaa
     4201 ctaaatcacc tttgttttcc ttgttccaat tattcaagaa attataatgc tggaaagaat
     4261 tgatatcaat ttcaccgttt tttaaagctt tattcggctg tgaataatct gtaaactctt
     4321 taaatttaag tttgatattt tcttttttaa gcagttcctc aattttatcc caacgttctt
     4381 tatcagaatc agtcatagtc atcacaccaa cagttaacgt atttttatca tttttttgac
     4441 cgcaagccgt taaaacaaat gccgcagcta aagccaatcc taaaagacct aatatttttt
     4501 taagtttcat cggttatcca ccttttctat taaagtaaac ctattctctc atatttaatg
     4561 agagctatca aattgttatt tcaaagattt ccttatagct aaaaactata gccatatcgt
     4621 taaaacactg gttttctcaa ttccaaaaaa tcaggtgaaa acctgatttt aacgaattat
     4681 ttcatatctt ttttatctgg aagatagctt cctccaaggt attttttcga taatttttca
     4741 agtgtaccat tctcgtaaag ttttttgaga cgtttattga caaacttttg taagtctttt
     4801 tggtcttgcg caaaaataaa gtaaacatat ggtttttggt ctgaaggaag atcaataact
     4861 ttcaaattat caagtccttg ctctttgatg atcgtttctg ctgaaatttt ttcaaaaatt
     4921 ttaaaatcat acttaccatc actgacatta cggatttgat gcgcaagatc ttcactggta
     4981 aagtttagtt taacttgatt gttttcatgg tttttattga atttctgcag cataggcact
     5041 gttgtatttc cttgaacaac ttgagtgcta tgcccagcaa tatcgttata agacttaata
     5101 tcactatctt ttggaaccac taataccaat ggattggaag ccgttggatt agaataaaga
     5161 tatttattgg cacgctcttt agtataactg atattgttag ctccgatttg atatttgtca
     5221 ctatctagac cagagaaaat gctggtccac tctgtttttt gatatttgac atcgtattta
     5281 tcagaagctt tgaaaacttc cttagcaacc tcaatatcat atcccgtcaa ttttcccttt
     5341 ttctcataag aaaatggatt tgttgtccca acagtcgcaa gggttaccgt ttttttagat
     5401 gattttgatc cgcaagcagt taacaaaaga attgaggcaa aagcaaccgc tccaattctt
     5461 aaaatatgtt tcaatttcat aattttcctc caagaatatg attataccta tcttatcact
     5521 aattgaaaag cttgcctatt atataattcc tatcacggcg ataagaaaat tctatcactg
     5581 ctcaaatcag gtactcttag cttttctgat aataatccag ccaaaagaga gcaatttcaa
     5641 tatggtaatt gacagcaact ggtagagctt catctttcac gataaaatca ttatagtgcc
     5701 agtcagctgc attctcatcg ccatttgatc ccgcaaggat gccaggaatt ttttctgatg
     5761 gactctaaaa tcctcaccac ctgctgaaga ctctacttcc agaacttcca caaatttttt
     5821 ggaattataa aaaaataaag gtgttaactg tgaactgcac gtcagcagtc tatccaaaac
     5881 tcagcttttt tacaatttaa ttttatctta actctatcaa aaaaaaaatc ccataagact
     5941 tataatgaaa agcaaccaac ctatcattag aaagcatttt atggaaccta tcaataatac
     6001 cactttactc atcggaatta aagacaaaca tatcagtttg aatgaggcaa ttcaacggga
     6061 tacacatacc aaaattatag ctacactaga ttatcatcct cctaatggaa acactgcacg
     6121 ggaaaacaga ttaagtatga cttccagaaa ccttctaaaa ttcctttcat cgaaattggt
     6181 ggttctccta gtcttatccg cttgaaaaag agaaggtttc agtgtaaatc ctgtcgaaag
     6241 ttaactgtct ctgaaaccac tctcgttaag aaaaattgcc aaatctctga ggtatctcag
     6301 ctcctactca acagaagaag ctcttaccct atcgcttcta aactcgctat ctttacctct
     6361 accatctatt gaaaactaaa ccagttccaa ttcaaagacg atgacacaac cttacctgaa
     6421 atactgtctt gggacgaatt ttcttatcaa aaaggctagc tagcttttat tgctcaaaat
     6481 ttctactccg agaaaatcat cactctcctc gataacagaa aacaagcaac catccgaaat
     6541 ctcttcttca agtattccaa agatgctaga aataaggaca aagttatcat tgtcgatatg
     6601 tctggtagat atatccctct tcattaagct attatttccg aataccaaaa tcgttcttga
     6661 ccgctttcat attgttcagc acatgaatag agcactcaag caaacccgta ttcaaatcat
     6721 gaagctattt gataagaaat cgctggaata tcgggcactg aaatactact ggaagatcat
     6781 tcaaaaagat agcagaaaac tctctcttaa tactttctac tctagaacat ttagagaaac
     6841 catgacgcct agagagtgtt ctcaataaga tcttcaaact ggttccggaa ctaaaagatt
     6901 attatgacct ctatgggtta ctcctttttt catttacaaa acaagaatgc cgaacgctta
     6961 tttagcttaa taaacgaggc gcttccacat cttaatcaca ccttcaaaac tgctttaaac
     7021 atctttattc gctataaaaa ctatatcact aatgccattg aactgcctta ttctaatgcc
     7081 aaacttgaag ctacaaacaa actcatcaag gacattaagc aaaatgcttt tgggtataga
     7141 aactttgaca actttaagaa acacacttcc ctcgctttga atataacaaa agagaagaca
     7201 acttttgtct ttagctataa gtcgcccact acagttgaca atgagacaaa aaaagtctta
     7261 ctaaccacat tgactaactg atcaatataa ttaaataaga ctattagata ggaatattta
     7321 tcatcatgta agtagtctat aaaattaata ttcactaata cgtattactt actacaattt
     7381 ctcatgcatt caacagtaac cgtacagata taacctttat ttcccaatac aatgctaaaa
     7441 gtagaattta ctactgttgt accaatacca gcagtaagtt gttctaagtt attagcatca
     7501 tccatgagaa ttgataactc ttcttgcaag cctgcttttt gaatctcttt cattataatt
     7561 tactcctatt ttctaattac ttatttgtta atacagcgag atgtgcacgc agttgatata
     7621 ccagtaactg ctacagtaat accaacaacc ccaattgcac atgccggagt agagccccca
     7681 gctaattcca tatcttcatc tttgatgagc gttaccatat ttttttccat ctctgttaca
     7741 ttatttattt ttaataaatt acttttcatt ttatattcct tcctattctt tataaactac
     7801 ctatcatcat aatgctccta tcttctcctt gtcccacccg gccacccaaa agttattgct
     7861 caatatatta tttaccagaa tacattcggt aatattctcc cttttgagcc atcaagctat
     7921 gatggtctcc aacttcagac acttgaccgt cttttaaaac aattattttg tcactatttt
     7981 ttatagtgct taatctatga gcaataacaa tctttgtttt agaatcttca gataaatatt
     8041 ctacaatttg atgttcagta atattatcaa gagcactcgt tgcttcatct aagaatagca
     8101 ttgatttttg atttaaaata gctctggcca aagctagtct ctgtctctgt cctcctgaga
     8161 agttgaaccc attttccgat actactgtat taatccccat aggcaatgaa taaacaaaat
     8221 caagcagagt aacttttttt agagcgtcat atatatcatt atcagcaacc tcgaaatctt
     8281 caactaaatt ttcttttata cttccgttaa acaataaggc atcctgagga accactccta
     8341 tctgctcacg taaagcatct ttgtttaaaa tctttaaatc tagtccttca aagtatatat
     8401 caccttcata gttatcataa gcacctaaca atatataaaa caacgtagac ttaccagaac
     8461 cactttcgcc aacaatggct acagactcgc cttcattaat tgaaaaacta atatcatcta
     8521 atgttttgtc ttcggcaccg ggatagacaa atgacaagtt gtttaccctt atattccctt
     8581 taaaatctat tgtacgattt cttactgctt cgtcctcctg caaaaggatg tcatctatac
     8641 gtatgaggta agactttgct gttgtaatat tgtctgataa ttgagctatg gagattagac
     8701 ctgaaatgta tgtacctgta atcgattgta aagatataat cgttccaact tggttactgt
     8761 gagccaatcc actaatccaa attcctaaga taggaatgaa aattggtaca taaagtgtaa
     8821 tatatgctag tatattttga tacaaagtga taaatcgctg atttttttca tgagacttga
     8881 tataatcctc ataatatcta tgccacgacc tatgcttttt tgagcttagc cctaacactt
     8941 ttacatcaaa aattgcacga aaaatatcat actgaaaaac ttgcaattta ctatccgttg
     9001 ccaactcctt gtttttgtac agcaacattt tctctcgcat aaacctgctc atggataata
     9061 ctagcaatgt aataaatgct aaaaagactg catataaagg ttgtaaattc ataatgtaaa
     9121 tgaggataat aaccatagaa cctatatcta aaaaagtttg aatgataata tcactaatta
     9181 tcgtttttaa attttttaat agtactaatc tatattggat atccgagcta gtacggttaa
     9241 gataaaattc aaatttattt ttaaataatt tatcaacaac cttttttgat aagaatttat
     9301 caacggagat agacagacgg atgctagtaa tttgcttgac tctattcact acaaagtaga
     9361 ccaaactgct tgcgattgta cctatagata gcgcccaaat tgtagtatct atctgtttgc
     9421 taactaaaaa attatcaaca agtcctttta atagtaacgg agcaactagt gtcaacgaat
     9481 agacaattac cgctgcaata agcacctgta caacgagttt cttgttaaag aatactgctt
     9541 ctttaatcag tgaaaattct tgtcctctag tattaacggt tttaaaattt tcgttaggcg
     9601 ttatcttaag tattaaattt ttatagtcat tatcaagttc atcttttgaa atttttgttc
     9661 gcccaaaagc tggatccaat ataataacct cattagaaga gattgactct actacgacaa
     9721 aatgtcctcc gattctataa gcgatgcctg gtaacgagga gttttttatt tctgagagtc
     9781 tatcagtcac cttaaacata ttcatggaaa aaccaaagtg gtcaaaaatt ttcttaagtc
     9841 ccctaatacg cgtcccgtct cttcccgcag agaattcttt aggaatatca ttcaaagtta
     9901 tgcgaacatc atagtattcc attaacatta cagcaacaca taatccacat tctgtttggc
     9961 tcatctgtag aagtggtgta atttttttct ttttaatttc ctacaccccc aaaaactttt
    10021 caatataaaa atcattttgg cttatgaacc ataaagtaaa tgctgtgcct aatcttccac
    10081 taaaaaatga aggatttaaa agattattaa attgctcata acgccattgg gtattttcta
    10141 ataatttttc tccttcttct atataggttt tgacctttat caatttacta taatggttat
    10201 tcaacaagcc tgattgtaaa attattttta gaactacaag agcacctgca tagccattaa
    10261 ctagagaatc atctacataa tcgctcctat ttctgaccaa aatacaatta agagctttaa
    10321 agagatcagt cataacaata tcttttaatt tcttgtaaag attggatgaa cgatagagta
    10381 agtgcctact aaaaagtatt cccacagctc catacgataa tgcacataga tcctcagtat
    10441 tagaaatatt gtgcctagta tcattccaat tattagaaac tttattaaaa ttagaattct
    10501 cgagttgaat aaggtcgaga atatctttat caatagtctg atgttctata tattggcgga
    10561 gaactgataa cactaaaata tcgcctgcat atccatgaaa caaaccagta agattacgct
    10621 tagtgtacgt ctttaaatat atttctccta atagttttat atcatctaga taagccttat
    10681 ttgaagtttc tttgtagaga tagtttaaaa ccagaatggc acttccatac gttgaaaaat
    10741 ctacaatatc tttttcatgt actatgtctt ttgaggatgt gtagttttgc ttctcagatt
    10801 ctaaattaaa ataatgatag agtaagtacg acgattgtct acctattagt ccagaaagac
    10861 cttcacttgt gccaccattt ctgactgtag ttattatttt ttctctcaat ttactatttt
    10921 tgcaatatct agctaaaaac aagagagaag cgccaaatgt atatatatca ttacaataat
    10981 gtaatagcgt attctgaaca gtgtgatcaa tcactccaaa tttaaaaccc acatcattcg
    11041 agcaaaatga ttcaaatgct tgtagttcat tatccacttt gtttccatta tccaaataat
    11101 gagatcgtcc ttctattgga acatctaatc ccaaaattag ctgcaaatag tatttttctt
    11161 tatttaaatc actaaggcta agcccctcaa ttctctttat gaggttgtcc ttaattattt
    11221 tattatcagt tacttcgctg attaaaaaat aagggatagc ttgttgtttc aaacaagcca
    11281 tttctttgtc aactattttt ttatcgcgct tactgtgctt cctcaatagg tggatatatt
    11341 tttctgattt ttccttactc ttagtgtaca ttggtaagtt taaatcatct aaatatttgc
    11401 cataaaaagc cgtgttacga agtacaaccc tataatcata gctctctatt aattctagtt
    11461 tctgaattaa cctctcctta tattttagaa aaattctaat tcctgtatcg aaacctttca
    11521 gtacatctgc tgaatactct tcaggattaa ccttggcacc atttatatct tgtggtatat
    11581 tactatgctt ttcagtataa ctgtagactc ctatattaat gtcatcttgc cccttatgaa
    11641 tgacaccata ccgccgagtg gttatatcac ctccactaaa tgcacttaaa tctagtgaac
    11701 catatacaag tcttttttct ttagaattaa atagataagt ttctgtcaat agtgagtcta
    11761 atttttctct atttagtgtg tccgttatag cagcttctaa atcaataaaa tagggaccat
    11821 attttgtaga aataatattc tcactatgaa ggtccttact tcctaaaatt gtaaaaatag
    11881 ctgtcataat tccgaattta taataaaaat tttggagttc tatgctattt aaaactgcac
    11941 tgtctgactt gatgtattct tgaaggcaca agtcatcgtc taagaaaatt gtatttgcaa
    12001 taggtagttt gatattttcc ttgtcaaaat atttttgaaa aattctcaaa agacgatccc
    12061 ctaaattggg acgcttcttg atcaatattc ttttttcatt tagtgtaagt atagctacaa
    12121 atgtattaat atggaaatca ccttcaaaga tattaagatt actaagagac agcgactcac
    12181 tttcttttaa actagcaacg tttcttattt ctacttggta attttgaagt aggctaaata
    12241 cttctttagt cctttgaata taattacaaa taacaacttc acaattatct ttcactgttg
    12301 gataaatctg atgaaattct tgaaaatatc tatctttttg aagattttca ttataatctt
    12361 tgtatgataa attaggattt atagcccttt cttcctgata atagtcgatt agagaactaa
    12421 ttgctactga tgatatattc tttaaaatac cctcaataag tgcatagtaa catttttctt
    12481 ggtcattttg gctgctgaat agtccttttg aatcaataga taataattgc tcatatatct
    12541 ttgaaatata gtgagaaaaa tagttttcaa atttgccctc tatactggga taggccgaat
    12601 ttcttatgtt ttccactatg cataacccca tttacgataa atcacaggca ataatgccat
    12661 caatgcaaca ctccaaacaa tagtaacaac atactgttcc ggagtgtatt tagcaaaact
    12721 aaaggcattt tcaacaaatg ataaaggaat atatttagtc aaatcagctg tagattcaaa
    12781 attattcata acattcatga tagtcacccc taatcttaat gtaaggaata gagtgatgaa
    12841 tgaatataat gaatttttta aaactaatgt gataatgctt cctaatgaaa agagaaatag
    12901 cgcataaact aagtaagccg gtaccagatg attaaaaatt tcaaataaat caatctgcgg
    12961 atgattaaaa taaattttat aaaatgcaac ttctacaaag gaaactaagc tagtcaaaat
    13021 agctaaaaac tcaactgcta ataattttct caaaataatt tcaatacttg atcgcccact
    13081 gattctaaga tgattgatag ttttatagcg aaactctcta ccaaaggcgt tgatagctgc
    13141 atacatcaat aagaaattgg aaacagtaga aaatacactg tagatattat aaacctgaaa
    13201 aggtcctttt aaattctcaa tagaatagat gattccccca ccaagcaata gggatagcat
    13261 cagaaaaata aatacactaa atttcataat aattggtctt acaaacaaga ccgttgccca
    13321 tttattgctc atcaaaatat acctcactca aacttatttt ttccttctga atagtaatat
    13381 tcttctctct ttgtaacatt tcttcaatgg catcaatatc acgaacaata atatccctac
    13441 cattttgttc atagtcgaaa ccattatctt ctaataagca gattagctca gattgagata
    13501 aatcaggatg ataaatctta tatttcatat gtttcttagc atccaagctg ctaattgtgt
    13561 gatttctcag cagaactgct ttgttgcaga tttgctccaa attttgtaag atgtggctgg
    13621 aaataataaa agtaatacct ttttcagatg ataatttttt tattaagtcc agtaaatttt
    13681 taataccaat aggatccaga ccattggtcg gttcatctaa taagataaac tcttcagaag
    13741 caatgagagc aataaacagt ccaactctct gcttcatccc caaagatagt tttgaaactt
    13801 ttttatgtaa ataactatcc acctgtaaaa catatttata atcatcaatg acgccgtaac
    13861 tcttgccaaa tagacgacag taaaacttca aattactcaa cactgtcata tcagcataga
    13921 ggctggggtg ttcaattaaa gtaccaacat tatgagcttg aatcttgata tctccttcat
    13981 agttaggaat gatacctgaa ataagcttca tcaaagttga cttaccagca ccattttcac
    14041 caactaagcc taggatatct ccttgttcta aagtaagatt aatgtttttc aatacataat
    14101 cttttccata tttaaaattt aaattttgaa tgtctaaaat tctcatgtca gcctccttaa
    14161 tctgatgtta tttttaaaat atccaaaaac ctaagatagt tatcacaaat cgtactgtcc
    14221 aaaaaagtag ctaccccaac taaaccatgc atcactccta tggtttcagt tcctcgaatg
    14281 tgatacctcg ttgcatttgt taaataagga aagatttctt gaatgtattt atctacctta
    14341 ctattttcaa tatcaagcat cacctcagca tatttacaaa taacaatgtt ccctaggtca
    14401 ccatgacaaa aagttaaatt cacacctagg gattttttta tagcgatctc atataattca
    14461 taagcttctt caataatata gtcatcctga tagccatgtt ttataagctc aagtctcgat
    14521 aaaagaatac ctggaattcc gtggcaccat ccccatgaat agctgtttct attattgtcc
    14581 ttaaaccaca tttgatttgt cttatcaaat aagcgtcttt ctgtttttag taacgatcga
    14641 ataagggtat agtcatctat atttaatagc ttgcttgctc tgtaaatagc taaagtaatt
    14701 ccagatgatc catgtgcgaa accagtaaaa taacgatttt tttcctgtgc aataggaaaa
    14761 taggcttccc ccttatcata aataatcgaa tctattagat gtaagcgaca tttctcaact
    14821 aatttaatca cacgattatt taaacagtca ctcaaatcta attgaaaaat ctctattaaa
    14881 gttaatatga cacctgccgt tccatctaag atgtccaatt tctcatcatt tttaaagccg
    14941 ttttctatta agtctaataa gtaatggatg cgtttcaaag ataagacact gaagttgtta
    15001 ttcttatata tataagcata atatcttaaa tactgagcta ttccgttgta agcaccgatg
    15061 ctggtgtcca ctgttccata attaataatt gcatctatat caatttcaat atcacttatt
    15121 aatttattaa taggtaaatc tttatagcct gatttttcga gcagtagcaa acatctcagt
    15181 attccaacgc tacccgaata ataactatca ggattttcat gaatttggta aaaacttcta
    15241 ttattatcac cttctaattc aggagttatc caaaaatatt gtttagttaa tggatttatc
    15301 agtttatttt caaaaacagt tgcaatcatt tgttcaaccg tctgcgccct ttgcttttgt
    15361 agactctctc cctcatgaat tgttacttca tttatctctt ttacgtcaaa ttctgcagaa
    15421 actactgtca gcatttgagt tattagtctt aattgtcttt caagatcctc ctcacatagt
    15481 atatttagtt tatgctctag gctttctagg ggcgtttcta taaagtagtt ttttattctc
    15541 ttatcatcaa ataaaagtaa atcagtacta tcagtgtcta attcaaaata tgggatgtta
    15601 aactttaaca attctttgta ttctagtact tcttcttcct gtatttcctc gcttaaaagt
    15661 ttcattgata ctgcaaaagc gtatttaaaa tgaaataggc acaccggatt ctttaatagt
    15721 cttaatattt gcgaatagtc atgggtttct ctatttaaat agcgaatagg agcattgtta
    15781 aataatcgat tgaaatattc tttatagcgc tctttatctt tgagaacctc attataaata
    15841 ttaataaaac ctctctgtat aaaacctatg acatctttca attcattttt ttggattaga
    15901 tggttagatt ttttccaagt ttctgcaaga gtatttggta actctccact atatattttc
    15961 agcgggctca aatcataaaa atctccatta ctttttacaa ttgtaggtaa tattatcaaa
    16021 ttacttacag agtcctccaa atagttaata ttatcctctt gtaacatttt tggagtcgtt
    16081 tgcttcttga acctcaatct actagtcaaa agtgtctcaa catctattgc tacaggaaat
    16141 tctccacaag atataatatt ttcataatgt aaatcgctgc cattaagtat atatgtaata
    16201 gctaataact gtcccagcct aatataatat ctctcatttt cattctttga ttgtaatggg
    16261 atatatcgaa tttcttcagc ccaagaatag cttccttgat caataatttt aggagctttc
    16321 atttttaata ttccatcttg ctcccctatt ttatctataa cttctttaaa taatgtatct
    16381 aacttacttc ttctcggttt ataaaaataa ttaccgaatt ttgattctac cttgatgaca
    16441 aatgttcctc tatgtctgtc tcccatagat agtttaatat ccgttatcat tccatctgct
    16501 tccaaaaact gattagcaac caaggcttta tcttgaatca aatgagaaag aaactctagt
    16561 aaatactttg tggtatctct tataaatgaa attattgaaa aataccagta aggatacttc
    16621 ttaacaactt ctgctaaatt tttatagtcc tgatttaaat aaactaaata ttcagtttga
    16681 tttttattga tatttctcat ctctgctatc cagacacctt cagatagaga agaaatattt
    16741 tctaacatat tctctgttat agttcgttca atggtatcac tttgaaaatt gtcatcatat
    16801 ttctgtaatt gatttcttat ctcaagtaaa tacggctcaa gaaatgataa atacaaatta
    16861 gaaaaagtat tgctgccaag aagatgaaat ctattccagg actcataaac ctcaaactcg
    16921 tctatgctag cgtttatatc ttctaataga ttcatcccaa attttttgta caatttttca
    16981 atatttgaat tatcacttaa cttaataaaa atattatcag tccttgtttc cacaacttcc
    17041 cccttaccaa gtttttacca ttttactatc taaaatcata tttttctgat attcctaaat
    17101 atgaaattaa ttttttatct ggctgcgcaa ccaacatctt tagtataaca atttattttc
    17161 aaaatggagc gaaatatcct aaacggtagc tattttgtct taaacggtca tttttgatgt
    17221 tctgaaacta tcattaccag ctatttttac attatgtatc ctaagaaaaa gattactttt
    17281 tcaagaaaat ccatgatttt ttcataaaaa aatagtatac tgaaaatgta taaaaagtct
    17341 tcttttgaga cttttcttag gtgatacgga cagtagcgat gaggaaactt tcgtttcctt
    17401 atgtcccaat ctgaaatagc tttatgacta tttcagcctt cagaattcca tacctaagat
    17461 ttgagcctag ggtctcaaat cttccgatat tttttatttt attaagacta tctctacaac
    17521 aacaaaaagc aacggcatca aaaccattgc tttttacgtt agtagggaag acattgtccc
    17581 agactcatct actgtgattc tagtaactgc ttcaaatttt ctcttaaaaa catgggaacg
    17641 agtggatctg ctaactctct gaccttgtct ataaaattct ctaatttccc caatattgtt
    17701 gtcccatttt ccatgtgatc aaggattgga attgtccagt cttcaatttt tatttcacaa
    17761 caatattaac cagtttgtta ggcactgcaa taacttttac aatatctttt cctgcaattt
    17821 ctgcttggat tttgtcgttg gcaagagcaa ttttttcaag atcttcacgg ctggaatcct
    17881 tagaaacaac aaccttggca cgaacttttc ctttgatttg aaggacaatc tcgatttcgt
    17941 cttcaaccaa tttggattca tcataacttg gccaagcaac ataagtaata gattgtccag
    18001 actgcgttaa gaattgccaa agctcttcag ctaaatgcgg tgcaaatggt gccaataatt
    18061 ggataaatcc cttagcataa tcaagaaaga gttgttcttc cttgttagcg gcattgacaa
    18121 aaatcatcaa ttgagaaata gctgtgttaa agcgcatagc ttcaagatgc tctgttacgg
    18181 ttttaaccac ttcattataa accttgtcta agtgtccatt gtttttggca gctatttctt
    18241 ttgttgtgat aagacggtag acacggtcaa ggaatttacg gctgccttca agaccttctt
    18301 cagaccaagc aatagaagca tcaagcggcc ccatgaacat ttcgtaaaca cgaagggtat
    18361 cagcaccata ttgttcgaca acatcgtcag gattgacaac gtttttgagt gatttggaca
    18421 tcttagccgg tgcttgttcc aactcttcat ctgtttcgat gttgaagaaa gaaccatcac
    18481 gtttttcaac tttatctgtt gctactaaag caccacgatg atcgcgatag ctggttccca
    18541 aaatcatccc ttggttaaag agtttttgga aaggttcttt ggttggtaca acactaagat
    18601 catagagaaa cttatgccaa aaacgtgcat aaagcaagtg gagaacggca tgttcagcgc
    18661 cgccaacata aacatcaact ggcaaccatt gtttcaaaag atcctcatcg gccaattttt
    18721 ggtcattatg cggatcaata tagcgtagga aataccagct agaacctgcc cactgcggca
    18781 tagtgttggt ttctcggcga cctttaacac cgtcttcacg cgtcacttcc aaccagtctg
    18841 tcaagttggc aagtggagat tcacctgtgc ctgaaggttt gatgtccttg gttactggta
    18901 agacaagtgg caattcattt tcaggaagag ctgtactcgt tccatcttcc caatgaataa
    18961 ttggaatagg ctcaccccag tatcgttggc ggctaaagag ccagtcacgc aagcgatagg
    19021 tcactttctt attaccgaca ccttcagttt caagccaagt caccatcttg tcaatagcgg
    19081 cagccttgtc aaggccgttt aagaaaccag aattaatatg caatccgtca tctgtataag
    19141 ctgcttctgc tacatttcca cctttaagaa cgggaatgat atcaagatta aactgtttag
    19201 caaattccca gtcgcgttcg tcatgagctg gaacggccat gatagcacct gttccgtagc
    19261 tagcaagcac gtagtcggct atccaaattg gaatctcctt gccattgaca ggattgatag
    19321 cataggcacc cgtccaaaca ccagtctttt ctttggcaag gtctgtacga gctaagtccg
    19381 atttgagact agcttgatgt ttataatcag caactgcttg cgcttggcca gcagtagtaa
    19441 taatatctac caaatcatgc tcaggagcaa gaacagcata agtagcacca aagagtgtat
    19501 caggacgagt ggtgaaaacg gtaaattcct catctgtgtc cttgactttg aaagttacat
    19561 tggcaccagt tgatttacca atccagttgc gttgcatatc tttgattgac tcaggccagt
    19621 ccagatcttc caaatcttct aagagacgtt cagcataagc tgtgattttc aacatccatt
    19681 ggcgcatagg tttacggaca acaggataac caccgcgttc agaagttccg tctggcagca
    19741 cctcttcatt tgcaatagct gtccctagtt cttcaaccca gttgacaggc acttcagctt
    19801 cataagccag acctttttca taaagtttgg taaaaatcca ctgagtccat ttatagtagt
    19861 taggatctgt cgtgttgatt tcacggtccc aatcataaga gaaaccaagt gatttaattt
    19921 ggcgtttaaa ggtcgcaata ttttgcgctg taaagtcagc aggatcatga cccgtgtcca
    19981 tagcatattg ctcagcaggt aaaccaaaag catcccagcc catagggtga aggacactgt
    20041 agccttgcgc acgtttgaaa cgactgagaa tatctgtcgc tgtatagccc tcagggtgtc
    20101 caacgtgtag gccagctcca gatggataag gaaacatatc aagggcataa aattttggtt
    20161 ttgaggaagc cgttccagtc ttaaaagtat ggttatcttc ccagaatttt tgccatttat
    20221 tctcaattgc tttgtgattg tagtaaacca taatattctc cgataaaaat atagtcttta
    20281 ttattatagc atttttataa ggaatgaaca gagtcaaata agaaacttgc agaggaaaca
    20341 gcatctagcg actgctgact gagtctcact aaaaaagctt acctactcca aatgataatt
    20401 acaagctgcc tacattttaa agggcatact ttttggaaaa aatactttag tttagactta
    20461 ggaattgaca agaaaaaaag acaagtgtag aatatcacaa agatatttta caagcgtaat
    20521 aatatctata tgcttaataa tgcggcatcc caattcttta ctgactatcc ctctacaaaa
    20581 atcttaagat aagagaataa tgccatattt taagtataat ctacaagaca atgcagaaag
    20641 aaggactatc atgttaaatg aaactatcca aaaagaattc caaagaaaag aaatcaaata
    20701 tttaattgaa gctgacacct ttgaacaatt acaaaaagaa tttaaagatt atcttactcc
    20761 ggatcgcttc actcattcct ccattaccaa tatttatttt gataatcccg actttcaatt
    20821 gattaaggat tcaatcaacc accgccatgc cagtgaaaaa attagaatgc gtacctatga
    20881 cccaaaacct actcaaaaaa gtcaagcttt tttagaaatc aagaaaaaag aatatcaggg
    20941 tgaacaagaa atcggttata aataccgtct gacatccacc cctttgtctc tttgcaatta
    21001 tgttcagcaa ggaataattg acaataacat aaaacaagat gacagagcta atcatgagct
    21061 tgctatttta cgagaacgtt ataaaaaact agtaccaaaa atgttcattc actatgaacg
    21121 cttttcacta aggggaattg aaaatcctaa acttcgcgtt acttttgacc gcaatgttat
    21181 ttatcgccac gaaaatgtta acctcacttc gggttttaat ggttatccac ttctaaaaaa
    21241 caatcaaatc gttatggaag tcaaagttaa aaatgggctt cctgcttgga tggaaaaaat
    21301 attccataaa caccagctaa ttccacaatc tttttcaaag tataccactg cttatttaaa
    21361 ggcttatgga ctaacacctg aagatatcag agaggagcct acgtcaattg cttaatcaga
    21421 tttttaacag tgttttctca aatcgagata ttactattag tcccagcatg ttcgccttat
    21481 ctatcttaat cagcctgctt ttaggattgt tactggctaa aatttataaa tacaagacta
    21541 tctatactaa agaattcatt attaccttgg ctaccttgcc tgtactcatt tccatgatta
    21601 tttttcttgt taatggtaat ttaggaacca gtgtcgctgt tgcaggaact tttggtctga
    21661 ttcgttttcg ttcagctgca ggcggtgcta aagaaattct ttatattttc tttgcaactg
    21721 ctgttggtat tgcaacaggt atgggctttc ttgtcctagc catcctgttt accttgacct
    21781 tgacccttgt gctttggctt tatgagaatt caggattttc acaggtcagc acaagcaggc
    21841 gacaggcaac ttttattgtt cctaataatg agattgatta tatccctatt ctggaaaaaa
    21901 tcctaaacaa aacttgccgt gaaataaatc tcatttctgt taaaaacatt aacaaaaaca
    21961 acaccattca aatggaatat catttagact taaaaccaga aatgaatgac ataggactta
    22021 tcaatagtat catgacttat aaccctgata ttgaagtcac tcttgatacc agtgccaaaa
    22081 aaaagaaaat tttatgacat ataacatgaa aaaggtctct tggtaacact atcccgagac
    22141 ctttttgttt cttccaattg ataattgact ctttataccc tatatccttc aacaagtaaa
    22201 acgataggtt gtcagactga taataccagc tgttctgcct ttatttcaca ttttctcgtt
    22261 gattaggcgc tgacatgtaa catggggttc agaatacaag ccccaaaagt tttttatagt
    22321 tctgcaattt gatacagttc aagttcagct tgagtttctg ctccaaacat attaatcata
    22381 attttaacct tattattttc aatttcaaca acacgaccct cttgacctac aaaggcacca
    22441 tcaataattt gcactacatc tccttctttg atgttagtat caataatatc aactgtttgt
    22501 cccatagaca agagaataga acgaatttct tcttcaagaa gcggagttgg tttagagcga
    22561 ttaccgtgtg agccgacaaa accagtaacg tttggtgtgt tacgcacaac aaaccaagcc
    22621 tcatctgtca taaccatctc gaccaaaaca tagcctggga agcgattttc ttcaacttct
    22681 ttagtcttgc cgtttttttc gacattaaca gtctgtgttg gaatttctac gcgtaaaata
    22741 ttatccaaca tattataagt ttgtgcccgt tgcaacagat tttcctttac tttattttca
    22801 tagccagaat aagtttgcag cacaaaccat cctttatcaa atgaatccat gatttacctc
    22861 caattttgta tattataaaa aagcctagat ggcttttgga aattttcgta cattattata
    22921 tcataaaagc ttaagaaccc ctagtctttt ttattaaata aacaaatttc ttcataaaaa
    22981 acagcctttt ccagctgttt tttactttta aaaacgtttt aataattcag ccaatcccag
    23041 agttaacagc ttatcaaaaa taaagatgac aagagcaaag aatgctgaat actccagaat
    23101 tgaaataaaa tcatgccaag attgtttacg tgttggccat gtcgtatgct ttagaactga
    23161 aaaaacgcca ccgatgaatt tcattgtttt ttctcctaac gtgtttcctt atgcaaggta
    23221 tattttttac aatatttaca aaatttatta acctctagtc gatttggttt aggattacca
    23281 ctcacgccga tagaataatt ccgtgagccg cattctacac aagctagact tgcttttttc
    23341 tgcgccataa tacctccata acttttttat tttaacatgg ttttcttatt cttgcaagtt
    23401 attcaaaata attcacaaca ctatcccaaa ctttcttggc cttatcaata atatttgaat
    23461 catccacttt tttcttaata gaatccgtag cattttgagc tttctcacga ataccatcaa
    23521 tgatattttg ggaattagaa ttagtttcat ccgaagtatc atctgaatca taggtagatt
    23581 taatgccgtc ttggaaataa gcatttttaa ccttaaattc tgttccttta gtatagggta
    23641 aaatgtaact tgcctgagtg ctaaagatat tggaagccgt tcctgaacta gaatcattca
    23701 aatagtgatt ttcatcagtc ttattaaaac ctaaccattg actaataaca acatcaggtg
    23761 tataaccaat cacccactgg tcactggcaa gattagaatc aaaattcgtt tcagttgttc
    23821 ctgtcttacc ggctaaagta taaccataag cattggcatt gacaccagtc ccgttagaaa
    23881 aagttcctaa catcatacta gtcattttgt ctgccacaga tttactgata acacgtttat
    23941 cattgggtgt gaatttcttc aaaatttcac cgctggcagt ttcaatgcga ctaatcaagt
    24001 gagcagttgg catcacgcct ccattagcaa atgttgcata agcctgagcc atctcaagtg
    24061 gattagttgt gacgcttcct cccaaagcaa cacctaattc ttttttagca gcatccatat
    24121 taagaccgaa ccttttacca taagaaaacg ccttattgat acccaattta tcaagcgtat
    24181 aaacagcagg aatgttatag gaattggcta gtgcctgata cataggaatg tcttctgttt
    24241 caatatttcc atagttattg ggtttgtaac catcaaaatc acgggaagta ttgggtaata
    24301 gtttatccat agaccagcct gaagcgattg cgggagtata aacagctagt ggtttaatcg
    24361 ttgaacccgg acttctatta gactgagtcg catagttata atttctaaaa gtaacatttt
    24421 ttgtgctatt aacacgtcca actaagcctc taacaccacc tgttttagga tccaaagcca
    24481 cactagcagc ttgagcactg gtattatcat aagtggatac aggaaagaga ctttcctcat
    24541 caaaggtttg ctgcatgcca gtttggtaat tctggtctaa ttcagtgtaa atcctataac
    24601 cattgttaac aatgtctttt tcactgatac catagacaga gctagcctca ctaataacag
    24661 catcaaaata agatggatat tgataatcat ctgtcttagc aacataagta tcacttatac
    24721 ggttccccat tcccactttt ttagcctcat tggcctgttt ctgcgatatt ttccccgcag
    24781 ccaccatatt ttgcaggaca gtatcgcgtc gactggtcgc attctcaata gaatacagtg
    24841 gattgtagat acccggaccc ttcaacatac ctgccaaagt agctgcctca tcaagtgtca
    24901 gccgactagc agaagttcca aaatactttt gactagcatc ttcgaccccc caaacaccat
    24961 taccaaagta ggcattgtta agatacatgg ttaaaatttc ttttttacta tattttttgg
    25021 tcaattccag agcgaggaaa aactcgcgtg cttttctttt aactgtttgt tcttgggtta
    25081 aaaaggcatt tttagccaat tgctgtgtaa tggtagatcc tccgcccgaa taacctaagg
    25141 taactatcgc taaaagcatc cgcttgtaat tgatgccact atttttatag aagcttctgt
    25201 cttctgttga aatcactgca ttttctaaat cgtcggaaat agcatcaagt tcaacataag
    25261 tccccttttg cccataaaga gttccagctt gtttttcatt tttatcataa ataaccgttg
    25321 ttgccttcaa agcctgtttt aaatcagaaa ctttggttgt cttagctaga taaaacaggt
    25381 aagagcctgt caaaagcaca aaaataccta ccgcaatcag caaaatctta ccgacatgat
    25441 aacggcgcca atatcttcta accaaaccat ttttagaaag acctatcttg ctcaaaatgt
    25501 tgctgaattt actagcctct tcctgtgcat aacgacggtg ataatggttg tcagaggctt
    25561 ggctagcttg attatcaaga ttttgaggca tcccattttc aacctctttg gagtcttgat
    25621 gatcaatatt tttatttgga aaaaatttct tttttaacag ttctaatata ctcatgacct
    25681 tattatatca attttaaaga aaatgatata ataaaatcat gacttttact gtaaaaatta
    25741 taaacccata tcctataggg actgtcaagg aactattaga agagcatttt ttaatcccaa
    25801 gaaagattag gcactttcta agaataaaaa agaatgtcac agttaatagt caagccgtca
    25861 attggcaaag tcttgtcagg cggggagata ttatccagct gaactttgat aacacagact
    25921 atcctatcaa gaaaattcct atgggaaaca agactttaat agactgtctc taccaagatg
    25981 aacatcttat tattgtcaat aaaatagaag gcatgaaaac acatgctaat gaccccaatg
    26041 aaatcgcact tctcaatcat gtttctgctt atgtcggaca gacctgctat gttgttcatc
    26101 gacttgatat gaaaaccagc ggtactgtca tgtttgctaa gaatccattt atcctgccga
    26161 tccttaatcg tcttttagaa aataagtcta tcaaacgcga atactgggct ttagcacaag
    26221 gtcaattttc tgaacgtgca attatttata gagagccaat tggacgcgat cgtcatgatc
    26281 gacgtaaacg agttgtggat cataagcatg gccagacagc tatcactcag gtttcactct
    26341 taaagcattt tcccaataat accagcctga tcaaatgcca acttcaaaca ggacgaaccc
    26401 accaaatccg tgtccatcta gcctatcatg atcatgccat tgttggcgat cccctataca
    26461 gtcagcaaac agctggtaga ctcatgctgc atgctcacca gttaaccttt actcatcctc
    26521 ttacacttga aaaaattaag gttgaagctc catctgcaac atttgaaaag ggacttccta
    26581 aataggaaat cctttttttc tgacttattt cttagttaag ctaatgcctg ttttaggact
    26641 gccactagta tcgcctgatt cccaatagac agtcgttata ctggagccat taatcttaac
    26701 accataagtg tattgatcat tagcaccgat atcatctaaa acggtaaaag cagcacgatc
    26761 tcctgattga tagtaatagc gataagtacc atctgaagtc ttttctgttt tttcaacttt
    26821 tgctgtctta gtcgtatctt cctttttatc atccttgtaa tccgtttttt tgattactgt
    26881 accatcttct gagaaggtca tggtaatggt cttatcatcc tgcttcgttt cccaagttcc
    26941 tattaattct tctggtaatg gcatcggact tttcacctga ttgtcttcac tgacaactgt
    27001 cggaccacta atagatttac gaatggtata gcc
//
