LOCUS       NZ_JAQCYD010000001     20870 bp    DNA     linear   CON 23-FEB-2024
DEFINITION  Streptococcus mutans strain AF36-21BH AF36-21BH.Scaf1, whole genome
            shotgun sequence.
ACCESSION   NZ_JAQCYD010000001
VERSION     NZ_JAQCYD010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 605237)
  AUTHORS   Lin,X., Hu,T., Chen,J., Liang,H., Zhou,J., Wu,Z., Ye,C., Jin,X.,
            Xu,X., Zhang,W., Jing,X., Yang,T., Wang,J., Yang,H., Kristiansen,K.,
            Xiao,L. and Zou,Y.
  TITLE     The genomic landscape of reference genomes of cultivated human gut
            bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 605237)
  AUTHORS   Zou,Y., Lin,X. and Hu,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2022) BGI Reaserch, BGI-Shenzhen, Beishan
            Industrial Zone, Shenzhen 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: MGI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/23/2024 01:23:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,988
            CDSs (total)                      :: 1,943
            Genes (coding)                    :: 1,890
            CDSs (with protein)               :: 1,890
            Genes (RNA)                       :: 45
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 38
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 53
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 33 of 53
            Pseudo Genes (incomplete)         :: 28 of 53
            Pseudo Genes (internal stop)      :: 23 of 53
            Pseudo Genes (multiple problems)  :: 22 of 53
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:29:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 321801
            Orig. end                         :: 342671
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQCYD010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20870
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="3"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20870
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10870](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10870
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            1913..2059
                     /locus_tag="PGX70_RS01620"
     CDS             1913..2059
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299875.1"
                     /locus_tag="PGX70_RS01620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FeoB-associated Cys-rich membrane protein"
                     /protein_id="WP_002264704.1"
                     /transl_table=11
                     /translation="MSTFIIAILIAAGAFLGIRHYIKQKGSCGDCDCACPVKDEMKKSS
                     KTH"
     gene            2180..3034
                     /locus_tag="PGX70_RS01625"
     CDS             2180..3034
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263561.1"
                     /locus_tag="PGX70_RS01625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="WP_002264705.1"
                     /transl_table=11
                     /translation="MTEIIDGKALAQKLQLHLANKVEQMKEKHGLVPGLVVILVGDNPA
                     SQVYVRNKERSAIKAGFKSETIRLSDSISEEELIEIIEGYNQDPSFHGILVQLPLPAHI
                     NDKKIILAIDPHKDVDGFHPMNTGHLWSGRSMMVPCTPAGIMEMLSAYHVDLEGKHAVI
                     IGRSNIVGKPMAQLLLEKNATVTLTHSRTKHLSEVTRCADVLIVAIGQGNFVTEEFVKE
                     GAVVIDVGMNRDKNGKLIGDVNFDHVAQKASLITPVPGGVGPMTITMLLEQTYQAALRS
                     VTK"
     gene            3031..3864
                     /locus_tag="PGX70_RS01630"
     CDS             3031..3864
                     /GO_function="GO:0052855 - ADP-dependent NAD(P)H-hydrate
                     dehydratase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019322331.1"
                     /locus_tag="PGX70_RS01630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-hydrate dehydratase"
                     /protein_id="WP_002282796.1"
                     /transl_table=11
                     /translation="MIIDDLLTKKIIKPRPLNSHKGTFGRVLLIGGNYPYGGAIIMAAL
                     ACVNSGAGLVMVATHKDNITALHSHLPEAMAFDMVEKDRLSEQITAADVVLMGPGLAED
                     DLAQTTFDVVWQAIKPKQILIIDGSAINLLAKRKPAIWPTKQIILTPHQKEWERLSGLT
                     IPEQIEAATQTALAHFPKETILVAKSHQTKIYQGQKIGHIQVGGPYQATGGMGDTLAGM
                     IAGFVAQFHTDRFEVAAAAVFLHSYIADQLSKEAYVVLPTRISAEITRVMKEMSE"
     gene            complement(4189..4920)
                     /gene="lrgB"
                     /locus_tag="PGX70_RS01635"
     CDS             complement(4189..4920)
                     /codon_start=1
                     /gene="lrgB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002271503.1"
                     /locus_tag="PGX70_RS01635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="antiholin-like protein LrgB"
                     /protein_id="WP_002264707.1"
                     /transl_table=11
                     /translation="MALLKSPIFGICFSLILYTIGQDLFKKSKGFFLLQPLFFAMVAGI
                     IVLVLLAKGLGTDVKTLYTQAYKPGGDLIFWFLNPATIAFAVPLYKKNDAVKKYWKEII
                     SSLIIGMVVSLVIIVAISKAIGLSQASTASMLPQAATTAIALPIAHAIGGNTAITAMAC
                     ILNAVIIYALGKKLVAFFHLNKSEIGVGLGLGTSGHTVGAAFALELGELQGAMAAIAVV
                     VIGLVVDLVIPIFSYMIGLVH"
     gene            complement(4922..5389)
                     /gene="lrgA"
                     /locus_tag="PGX70_RS01640"
     CDS             complement(4922..5389)
                     /codon_start=1
                     /gene="lrgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262111.1"
                     /locus_tag="PGX70_RS01640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="holin-like protein LrgA"
                     /protein_id="WP_002270862.1"
                     /transl_table=11
                     /translation="MKHTSKVTQSKSAPMFIQMSIYAAILLVSQLISELLPKALPIPTT
                     VIGLILMYVLLCSHIIKIEWVDSLGSLLISMIGFMFVPSGISLAANLNILKAEGLQLVA
                     VISLSTILMLVIVTYITSIILSIKKVNVASLWEKWIAHSFEKKFSKKVEGK"
     misc_feature    complement(5442..5453)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.05"
                     /tool="antismash"
     misc_feature    complement(5489..5501)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            complement(5565..6299)
                     /gene="lytR"
                     /locus_tag="PGX70_RS01645"
     CDS             complement(5565..6299)
                     /codon_start=1
                     /gene="lytR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262110.1"
                     /locus_tag="PGX70_RS01645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="two-component system response regulator LytR"
                     /protein_id="WP_002262110.1"
                     /transl_table=11
                     /translation="MNILILDDEMLARQELTFLIQQSKELDHPDIFEAEDISSAEKILF
                     RQQIDLIFLDISLSEENGFTLANQLEQLAHPPLVVFATAYDHYAVKAFESNAADYILKP
                     FEQGRVDKALAKVKKIQHLSTIDETATTEKKGMELLTLTLADRSIVLKMPDIVAASIED
                     GELTVSTKNTSYTIKKTLNWFKTRAKTNYFLQIHRNTVVNLEMIQEIQPWFNHTLLLVM
                     VNGEKFPVGRSYMKELNAHLTL"
     gene            complement(6280..8022)
                     /gene="lytS"
                     /locus_tag="PGX70_RS01650"
     CDS             complement(6280..8022)
                     /codon_start=1
                     /gene="lytS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262109.1"
                     /locus_tag="PGX70_RS01650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="two-component system sensor histidine kinase
                     LytS"
                     /protein_id="WP_002267218.1"
                     /transl_table=11
                     /translation="MLMILLFQRLGIIMILAFLLVNNSYFRQLIEERSKREKLVLIIIF
                     GIFVIISNMTGIEITSDKSLVERPILTTISHSDSLANTRTLVITTASLVGGPLVGTVVG
                     FIGGVHRFFQGNFSGAFYIVSSALVGYISGRLGDQLKTNNLYPSTSQVIVISIIAESIQ
                     MLFVGFFTGWDLVKLIFIPMMLLNSLGSTLFLAILKTYLSNERQLRAVQTRDVLDLTQQ
                     TLPYLRQGLSQQSATKVCNIIKQHTNFDAVGLTDRTNVLAHIGVGQDHHIAGQAVKTDL
                     SKSVILNGQPQIALDKTAIACPDQSCLLNSAIVVPLKINNETVGALKMYFSGDKKMTEV
                     EENLALGLAQIFSGQLAIGIAEEQNKLANIAEIKALQSQINPHFFFNAINTISALIRLD
                     ANKARYALMQLSTFFRTSLQGGQDREITLEQEKAHVDAYMNLEKLRFPDKYQLNYHITV
                     STKMTLPPFGLQVLVENAVRHAFKERKKDNHICISITDQGEFYKVAVSDNGQGISPNMI
                     DKLGQETVSESKGTGTALVNLNNRLNLLYGSASQLHFDSTDQGTTVWYEIPYQKGDKDE
                     HFNS"
     misc_feature    complement(8120..8135)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.6"
                     /tool="antismash"
     gene            8465..9808
                     /gene="xseA"
                     /locus_tag="PGX70_RS01655"
     CDS             8465..9808
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014678150.1"
                     /locus_tag="PGX70_RS01655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_002266419.1"
                     /transl_table=11
                     /translation="MSDYLSVSSLTKYLKLKFDRDPYLERVYLTGQVSNFRRRPNHQYF
                     SLKDEKAVIQATMWSGIYRKLGFELEEGMKINVIGRVQLYEPSGSYSIIIEKAEPDGIG
                     ALAVQFEQLKKKLAEAGYFDDRHKQRLSQFVKKIGVVTSPSGAVIRDIITTVSRRFPGV
                     DILLFPTKVQGEGAAQEVADNIRLANERTDLDLLIVGRGGGSIEDLWAFNEEIVVQAIF
                     ESHLPIISSVGHETDTTLADFAADRRAATPTAAAELATPVTKADLLAFLKERQMRSYQA
                     VMRLIRQKDEQVKKLQRSVIFRQPERLYDAYVQKLDHLRTHLLTKVRQVYDVYDSKEHL
                     LRQRLLSLNLSGCIQRYQAQLKQDQRLLLSHMSSQYDSKLARFEKAQDALLSLDTTRIV
                     ARGYAIVQKDNHIIQSTQQIKKGDRLHLEMKDGQVQVEVENVKQEENI"
     gene            9783..10004
                     /locus_tag="PGX70_RS01660"
     CDS             9783..10004
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262107.1"
                     /locus_tag="PGX70_RS01660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_002262107.1"
                     /transl_table=11
                     /translation="MSNKKKTFEENLQDLEEIVNQLETGEIPLEEAITQFQKGMALSKD
                     LQKTLESAEKTLVKVMQADGSEAEMDEL"
     gene            10001..10870
                     /locus_tag="PGX70_RS01665"
     CDS             10001..10870
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002279431.1"
                     /locus_tag="PGX70_RS01665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_002276708.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.8e-52, bitscore:
                     172.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKIKYINQAIKHYYAQTHVSQDLVEAVLYSVAAGGKRIRPLLL
                     LEILQGFGLVLTEAHYQVAASLEMIHTGSLVHDDLPAMDNDDYRRGQLTNHKKFGEATA
                     ILAGDSLFLDPFGLLAKADLRADIKIKLVAELSDAAGSYGMVGGQMLDIKGEHVQLNLD
                     QLAQIHANKTGKLLTFPFVAAGIIAELSEKALARLRQVGELVGLAFQVRDDILDVTASF
                     SELGKTPQKDIEADKSTYPSLLGLDKSYAILEDSLNQAQAIFQKLALEEQFNATGIETI
                     IERLRLHA"
     gene            10863..11690
                     /locus_tag="PGX70_RS01670"
     CDS             10863..11690
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014834880.1"
                     /locus_tag="PGX70_RS01670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TlyA family rRNA
                     (cytidine-2'-O)-methyltransferase"
                     /protein_id="WP_002262105.1"
                     /transl_table=11
                     /translation="MPKERVDVLAYKQGLFNTREQAKRGVMAGLVVNVINGERYDKPGE
                     KIDEATELKLKGDKLKYVSRGGLKLEKALKVFVISVDGQITLDIGASTGGFTDVMLQNG
                     AQLVYAVDVGTNQLVWKLRQDERVCSMEQYNFRYAEPSDFERGQPTFASIDVSFISLNL
                     ILPALSKILTDGGQVVALIKPQFEAGREQIGKHGIVKDKSVHETVLETVTTFATNYGFT
                     VKELDFSPIQGGHGNIEFLAYLEKSAQAQNQVLTKIKSIVEQAHKEFKKNEET"
     gene            11677..12141
                     /locus_tag="PGX70_RS01675"
     CDS             11677..12141
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002278192.1"
                     /locus_tag="PGX70_RS01675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arginine repressor"
                     /protein_id="WP_002264713.1"
                     /transl_table=11
                     /translation="MKKRERLELIKKIVLENEIETQKELVKLLENEGLQATQATISRDI
                     NEVGIIKVPASNGRYIYGLSKEISKKEESTPKPAEKAVKFISDQVAGLEHLIHIDVVPG
                     NSYLLKRFLLERFEGLIFSLLADDDSLLLIVKNAKDSDRIRQEIKSWMAN"
     gene            12158..13816
                     /gene="recN"
                     /locus_tag="PGX70_RS01680"
     CDS             12158..13816
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312509.1"
                     /locus_tag="PGX70_RS01680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA repair protein RecN"
                     /protein_id="WP_002280392.1"
                     /transl_table=11
                     /translation="MLLEIAIKNFAIIEEISLNFEKGMTVLTGETGAGKSIVIDAMNMM
                     LGSRASIDVIRHGSPKAEIEGFFSVDKNPSLEQLLADQGIAFSDELIIRREILQNGRSI
                     SRINGQMVNLATLRAVGQYLVDIHGQHDQEELMRPQKHIQLLDEFGDEVFQVSKQHYQD
                     LFDRYRNLRKRVLNKRKNEQEHQARIEMLEYQIGEIEAANLQSGEDTKLLKQRDKLMNH
                     KLIVDTLTNAYVLLDNEDFSSLTNVRSAMNDLQSLEEYDAEYKDLSNNLSESYYILEDV
                     SKRLETILDHMDFDANTLVKLEARLDVINTITRKYGGSVDDVLAYFDNISKEYNHLTGN
                     DLAFDDMERELKVLERSLLEAAAQLSQKRHAIAETLSQEIKQELKDLYMDKADFKVVFT
                     KGKFNREGNETVAFHISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRREDKTSIVFD
                     EVDTGVSGRVAQAIAQKIYKIGNHGQVLAISHIPQVIAISDYQYFIEKQSSKATTVSTV
                     RLLNQEERIEEIAKMLAGDNVTQAARQQAKELLKK"
     gene            14041..14880
                     /locus_tag="PGX70_RS01685"
     CDS             14041..14880
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264715.1"
                     /locus_tag="PGX70_RS01685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DegV family protein"
                     /protein_id="WP_002275946.1"
                     /transl_table=11
                     /translation="MSKIKIVTDSSITIEPDLVEALDITVVPLTVMVDGIVYSDNDLKE
                     DGKFLSLMRNSKSLPKTSQPPVGLFAETYEKLIKEGAEQIVAIHITHSLSGTLEASRQG
                     ANIAGADVTVLDSAFTDQAMKFQVIAAAKLAQKGSSLEEILARVEEVKKKTELFIGVST
                     LENLVKGGRIGRVTGLISSLLNIRVVMELKNHALNPIAKGRGNKTFNKWLDNLIATIKD
                     RKIAEIGISYAGASDFANGLKDKLQAYVEKDIAVLETGSIIQTHTGEGAFAVMVHYE"
     gene            14873..15730
                     /locus_tag="PGX70_RS01690"
     CDS             14873..15730
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002312511.1"
                     /locus_tag="PGX70_RS01690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_002262101.1"
                     /transl_table=11
                     /translation="MSKKIPKGPAFFLANLLIFSLLFYFFIPTAKLSFKNSDQKSSLNK
                     SKATSFHYIAIGDSLTQGVGDTTDQGGFIPLLSQELKSNYHYNVLSSNYGVSGNTSQQI
                     LIRMRKERKIQKSLNKANLMTLTVGGNDVMTVVRKGLTNLKVSSFRQPAKTYQKHLRKI
                     IQMARRRNKDLPIYIIGIYNPYYLNFPNMTQMQDIIDNWNKGTQKVVAEYRNVYFVPIN
                     DLLYKGVNGEQKAVGTSDSEAESGEVTNDALSEGDRFHPNNVGYQIMSKAIMEKISETK
                     KNWK"
     gene            15705..16304
                     /locus_tag="PGX70_RS01695"
     CDS             15705..16304
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002266412.1"
                     /locus_tag="PGX70_RS01695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YpmS family protein"
                     /protein_id="WP_002275372.1"
                     /transl_table=11
                     /translation="MKQRRTGNKKNWWKWAFLLLLALNIAFWGVIISRVLSGYHSNTIT
                     SQTVKNPVKVGTITTTKEQLNQTLASYLNDYQYKGMTYSVQLTSTNIEFQGTYKLLGYN
                     VPLYIYFEPYQLKSGAVQLKVTSFSVGNLPLPASEVLSYIKSSYKLPNFVDVIPEKSVV
                     NINLQKIDNDAGIYLKSTAINLVSDEINFDILKKKR"
     gene            16401..16676
                     /locus_tag="PGX70_RS01700"
     CDS             16401..16676
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /locus_tag="PGX70_RS01700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_002262099.1"
                     /transl_table=11
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQL
                     IGFGNFEVRERAARKGRNPQTGEEIKIKASKVPAFKAGKALKDAVK"
     gene            complement(16768..>16905)
                     /locus_tag="PGX70_RS01705"
                     /pseudo=""
     CDS             complement(16768..>16905)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /locus_tag="PGX70_RS01705"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="YEKSFKSLDKLEKAITNYIFDYNNKRIKTKLKGLSPVQYRTESFQ
                     "
     misc_feature    complement(16919..16928)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(17049..17058)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 15.51"
                     /tool="antismash"
     gene            complement(17096..18214)
                     /locus_tag="PGX70_RS01710"
     CDS             complement(17096..18214)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803937.1"
                     /locus_tag="PGX70_RS01710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002280164.1"
                     /transl_table=11
                     /translation="MKKKVIITTIAAFLFILFSVGAIIFTIGKTANTQTNIQLERTSSD
                     IEHALYYASFAANSHNTQSWKVNLDPKQKRLGGFLNNKRSLNVVDPNNRELYISIGCYI
                     QSLKKSFEAYGYNVSISNIAPSKENKYQVVLINYQKLKNNKINNKQLDIIQKRHTDKRK
                     FQKKPINRTVVSSLIKKYDNVYYYAKGSKTFKYLQKGSLAAAAKQYKSQDFLKEQGKWL
                     RFSNQEAKKKQDGISGDMLGLNPIIKTFYYLTSNHKNATSNNFVKQSKNTLINQVENCA
                     GFFVITGEQNISKWIAVGEKSQAFWYDCVRNNIAVQPISAMIEIPSYNQKLQQNLGKSQ
                     PVQLILRVGYVNSYGKNVGPRRNLKDYITVKK"
     gene            complement(18221..18862)
                     /locus_tag="PGX70_RS01715"
     CDS             complement(18221..18862)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283232.1"
                     /locus_tag="PGX70_RS01715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002263256.1"
                     /transl_table=11
                     /translation="MARRKKEPARIHRKNISDAANTLFISKGITDTTMDNIAKLAGYSK
                     ATLYVYFENKEEIFFSLVYKHAKWLYETIEKIIQIQPSTQEEWQKNYLKICFALQKLCE
                     TYPIYFDGMIGHINVDMTSKETPQVYRDIYQLGLDINQLINTLIEDGVHLNYLQTELDF
                     NQSTLFFWSALSGIIRMAENKKEYYRLLGLDNKTFLEEEFLTLLACYKKG"
     gene            19125..19601
                     /locus_tag="PGX70_RS01720"
     CDS             19125..19601
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014834882.1"
                     /locus_tag="PGX70_RS01720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_002263255.1"
                     /transl_table=11
                     /translation="MGLHSHNNDPNKDVYDHVLTHLKEKHIRITKTREAVISYMINSRR
                     HPSAEQIHKDLLPQYPSMSLATVYNNLKVLIDEGFVVELKLSNDNTAYFDFMGHQHLHV
                     VCESCGKITDFVDTDISHIKQEAYKQTNYVITRAQLLIYGICPDCQSKKTKKAD"
     misc_feature    19663..19678
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.33"
                     /tool="antismash"
     gene            19664..19819
                     /locus_tag="PGX70_RS01725"
     CDS             19664..19819
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019321497.1"
                     /locus_tag="PGX70_RS01725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002263254.1"
                     /transl_table=11
                     /translation="MKFIIIVLIVFSIVKIISIIWVSKIMKPKPMTPKEIEEYDRKEDQ
                     KDGFDF"
     misc_feature    complement(19666..19681)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.49"
                     /tool="antismash"
     gene            complement(19882..20817)
                     /locus_tag="PGX70_RS01730"
     CDS             complement(19882..20817)
                     /EC_number="1.3.98.1"
                     /GO_function="GO:0004152 - dihydroorotate dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803938.1"
                     /locus_tag="PGX70_RS01730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydroorotate oxidase"
                     /protein_id="WP_002263253.1"
                     /transl_table=11
                     /translation="MVSTHTTIGSFDFDNCLMNAAGVYCMTREELAAIDHSEAGSFVTK
                     TGTLEERAGNPQPRYADTKLGSINSMGLPNLGINYYLDYVTELQKQPDSKNHFLSLVGM
                     SPEETHTILKMVEASKYQGLVELNLSCPNVPGKPQIAYDFETTDQILSEVFTYFTKPLG
                     IKLPPYFDIVHFDQAAAIFNKYPLTFVNCINSIGNGLVIEDETVVIKPKNGFGGIGGDY
                     VKPTALANVHAFYKRLNPSIQIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPQIF
                     KRITKELKAIMTEKGYETLEDFRGKLNAMA"
ORIGIN
        1 tgatgccacg aatctggaac gcaaccttta cctaacgacg cagttaattg agacaggaat
       61 tcctgtaacg attgcgctta atatgagcga tgtgttaaaa aatcaaggaa aatctattaa
      121 tagtgataaa ttggcttatc agatgggagt gccagttgtt gcgaccagtg ctttgaaaaa
      181 tacaggcgtt gacaaggctg ttaaaaaagc cagtcaaaca actaaggaca gtgttgatag
      241 tgttcaatat ccaacttacg atgccaaatt tgaagcggcg attgcccaaa ttattgaggt
      301 tctcggtcag acagtaccag aacgttctag ccgtttttat gccatcaaat tatttgagcg
      361 cgaccgtttg gttgaagagg aattagattt atctcccttt caaaagaagg aaattaaaga
      421 catcattcaa atcaccgagg aagtcttcac agaagattca gagtccatcg tgattaatca
      481 gcgttatgct ttcattgaac gtgtgagcca aatggcacaa agtcaagata atgattttaa
      541 gatgtctgct tctgataaaa ttgataaaat tgtgactaat cgtgttttgg ctctgcccat
      601 ttttgcggtc gttatgttct tagtttatta cttgtccatt caaacagtgg gaacaatggg
      661 gacggattgg gttaatgatg ttctttttgg taaatacgta cctgaattta taacaggtat
      721 tttagaaact ttgaaggtgc aggcttggct acaatcattg attattgatg gggttgttgc
      781 tggtgttgga acagttcttg gctttttacc gcaaattttt gtcctcttta tttgtctggg
      841 aattctagaa gatattggtt atatgagtcg aattgctttt gttatggatc ggattttcag
      901 acgtttcgga ctttcaggaa aatcctttat tcctatgctt atttcaacgg ggtgtggtgt
      961 tccgggaatt atggccagtc gaaccattga gaatgaacgt gatcgccgta ttaccattat
     1021 gacaacgact tttatgcctt gttcagctaa gctgtccgtc attgccttaa ttgcgggagc
     1081 ctttttccct cataatcctt ggatagctcc aagtgcttat ttcatgggaa tgattgctat
     1141 tattttatca ggtattgccc ttaagaaaac tagtttttta ggcggttata cgagtccttt
     1201 tatcatggaa ttaccaagtt atcatctacc aaaggttgat gctgttttgc gctatgcttt
     1261 tggtaaggct atgagttttg ttaagcgtgc tggaacgatt atctttagtt taaccgtttt
     1321 aatctggttt atgagttcct ataattttac tttgcattca gttgatacgg aaaacagtat
     1381 tttggctagt cttggtcgtc tcttggcttg gatctttaca ccgcttggtt ttggaaattg
     1441 gaaggcgact gttgctgctc taactggtct tgcagctaag gaaacagtag ttgcaacttt
     1501 tggaattctc tacaataatc ccgatgcaac agaaacaacg cattcactat gggttagcct
     1561 tcagggggat tatacagctt tggcagccta ttcatttttg accttcaatt tgctttgtgc
     1621 gccttgtttt gcctcaatcg gagctatcaa acgcgaaatg gggaatctga agtggacttt
     1681 agtggctatt gcttatcaaa cgggtctggc ttatcttgtt agcttaatta tttaccagct
     1741 tggtttagtc gctttttatg gcaagccagt gacgctttgg acaggtttag ctcttgtttt
     1801 attgcttgtg atgctttact ttattgttag aaaaccacgt caggtcaaag aaaaagtgat
     1861 taccttagat aatttaagtt taagtcataa ctaatagaaa ggaagaatga ctatgtcaac
     1921 ctttattatt gctatcttaa ttgcagctgg agctttctta ggaattcgtc attatattaa
     1981 gcagaaaggt tcttgtggcg attgtgactg tgcctgccct gttaaagatg agatgaaaaa
     2041 atcaagcaag acacattaag acaaagcttc atattttgaa ctgattataa tatttaaata
     2101 tagaaaaaaa ggtgtagcag cgtgttatct gctcgccttt tttggtataa taaaagcagt
     2161 atcttttcag gagatgagaa tgacagaaat tattgatggt aaagccttgg cacaaaagct
     2221 gcaattgcat ttagccaata aagttgaaca gatgaaagaa aaacatgggc ttgttcccgg
     2281 tcttgtggtg attttagtag gtgataatcc tgccagtcaa gtctatgtgc gtaataaaga
     2341 gcgctcagct atcaaggcgg gatttaaaag tgaaaccata cgcctatctg actctattag
     2401 tgaagaagaa ttaattgaga ttattgaagg ttataatcaa gatccttcct tccatggtat
     2461 tctggttcaa ttgccgctgc cggctcacat taatgataag aaaatcattt tagccattga
     2521 tcctcataag gatgtagatg gctttcatcc tatgaatact ggtcatttgt ggagcggtcg
     2581 ttccatgatg gtaccttgta cccccgctgg tattatggaa atgctgagtg cctatcacgt
     2641 tgatcttgaa gggaagcatg cagttattat tggtcgttcc aatatcgttg ggaagccaat
     2701 ggcgcagtta ttgctcgaaa aaaatgcaac agttaccctg acccattcta gaacgaaaca
     2761 tttatcagaa gtcacacgct gtgcggatgt gcttattgtt gctattggtc aaggaaattt
     2821 tgtcactgag gaatttgtca aagaaggtgc tgttgtcatt gatgttggca tgaaccgtga
     2881 caaaaatgga aaacttatcg gcgatgttaa ctttgaccac gtcgctcaaa aagccagcct
     2941 cattactcct gttccgggtg gtgtcggtcc tatgaccatc accatgcttt tggaacaaac
     3001 ctatcaagca gctttaagaa gtgtgaccaa atgattattg atgatctttt aacgaaaaaa
     3061 ataattaaac cacgtcctct taacagtcac aaggggactt ttggccgtgt ccttttgatt
     3121 ggcggcaact acccttacgg tggtgctatc atcatggctg cccttgcttg tgtcaatagc
     3181 ggagctggtt tggtgatggt tgcgacccat aaggacaata tcacagctct gcacagccat
     3241 ttacccgaag ctatggcttt tgatatggtt gaaaaagatc gtttgtcaga gcaaataaca
     3301 gcagcagatg tggttcttat gggaccgggc ttggcagaag atgacttggc tcaaacaacc
     3361 tttgatgtgg tttggcaggc tatcaaacca aaacagatcc tgattattga tggctctgct
     3421 ataaatctat tagccaaaag aaaaccagct atttggccaa ccaagcaaat aatcctaaca
     3481 ccccatcaaa aagaatggga aagattgtct ggactgacta ttccagaaca gatagaagca
     3541 gcaacacaaa cagcactagc tcattttcca aaagaaacca tcctagtcgc aaaatcccat
     3601 cagaccaaga tttatcaagg acaaaaaatc ggacatatcc aagttggcgg tccctatcaa
     3661 gcgactggcg gtatgggaga taccttggct ggaatgattg caggctttgt tgctcaattt
     3721 cacacagacc gctttgaggt tgccgcagcc gctgttttcc tccactccta catagcagac
     3781 caattgagca aagaggccta cgtcgtccta ccaaccagaa tcagtgcgga gataacaaga
     3841 gtgatgaagg agatgagtga gtgatatgac gaaaatagta ttaaacgata tttttaaatt
     3901 tgatgaattg cctttcctca cctattaaat cttcagaaca agaagtaatc tatcaagctt
     3961 aaaagctaaa ttagacaaag gatatcaaga tattttagat ggtaatatga tagatgctaa
     4021 agaggtcttt gctgaatacg atttataagc ttaattgaca attatgtgag gtagaatttt
     4081 attaattaaa tgaatttttt tgttttcctt tcatacccct acttttaaaa agcctttcgc
     4141 ggaatcatcc gtgagaggct tttgtcttat cgatagcagt tttaattttt agtgcactaa
     4201 tcctatcatg tagctaaaga taggaataac caagtcaacg acgaggccga tgacaacaac
     4261 tgcgatggca gccatggcac cttgtagttc tcctaattct agagcaaagg ctgcaccaac
     4321 tgtatgacca gatgttccta aacctaagcc aacaccgatt tcactcttat tgaggtggaa
     4381 gaaagcaact aattttttgc ctaaagcata gatgataacg gcgtttagga tacaagccat
     4441 ggcagtgatg gcagtattgc cgccgatagc gtgagcaata gggagggcaa tggctgttgt
     4501 tgctgcctgc ggcagcatag aagcagtgct agcttggctt aaaccaatag cttttgaaat
     4561 agcaacaatg atgactaagg aaacgaccat accgataatc aaactgctga tgatttcctt
     4621 ccaatatttt ttgacagcgt catttttctt ataaagtgga acggcaaagg caatggttgc
     4681 gggattaagg aaccagaaaa tcaaatctcc gccgggttta taagcttgag tatataaggt
     4741 tttaacatca gttcccaatc cttttgccaa taaaacaagt acgataatgc ctgcaaccat
     4801 agcaaagaaa aggggttgta agagaaagaa gcctttactc tttttgaata aatcttgccc
     4861 gatcgtataa aggattaatg aaaaacaaat accaaaaata ggtgatttta acagtgccat
     4921 cttattttcc ctctactttc ttgctaaatt tcttttcaaa gctatgagca atccattttt
     4981 cccacagact tgccacattc acctttttaa tggacagaat gatagaagtg atataggtga
     5041 caatgactag catgagaatg gtcgataggc taataacagc gaccaactgc aatccttcag
     5101 ctttgagaat atttaaattg gctgctaggg aaatacctga tgggacaaac ataaagccaa
     5161 tcatactaat taataaggaa cccaaggaat caacccattc aattttgata atatggctgc
     5221 acaagaggac atacatgaga attaaaccaa taacggtggt tggaatcggt aaggctttag
     5281 gcaataattc tgaaataagc tgagaaacga gcagaatagc agcatagata gacatttgaa
     5341 taaacatagg tgctgatttt gattgtgtta ctttactagt gtgtttcata atacgaacga
     5401 ctccttcctt tcttgacaat gttattgtag ctcattttgt gtaaaacgtt ttcaaaattg
     5461 tccccgattg caaaaaaaag aagctgaatt gcaatatcca acttcttaat gccaatgtaa
     5521 aattgtcaaa tgaaaatttt gaggagttaa tgaaactagt tcatttataa ggtcaaatga
     5581 gcattcaatt ctttcatata ggaacgcccg actgggaatt tttcaccatt gaccatcacc
     5641 agtaagagcg tatggttaaa ccaaggctga atttcctgaa tcatttccag attaacaact
     5701 gtattgcgat gaatctgcag gaaataattg gtcttggcgc gagttttaaa ccaattcaat
     5761 gttttcttga tggtgtagct cgtgtttttg gtactgacgg tcagttctcc atcttcaatg
     5821 ctagcggcca caatgtctgg catcttaagg acaatgcttc tatctgctaa agtcagtgtt
     5881 aacagttcca tacctttctt ttctgtcgta gctgtttcat ctattgtaga taagtgttgt
     5941 attttcttaa ctttagccaa agctttatcc acacgcccct gctcaaaagg cttcaaaata
     6001 tagtcagcag cattgctttc aaaagcttta acggcataat gatcataggc tgtcgcaaag
     6061 acgacaagtg gaggatgtgc caattgctct aattggttgg ccaaggtaaa accattttcc
     6121 tcgctgagtg aaatatcaag aaaaattaaa tcaatctgct ggcgaaagag aattttttca
     6181 gcactgctaa tatcttcagc ttcaaaaata tcaggatgat caagttcctt actctgctga
     6241 attaaaaaag ttaactcttg tcttgccaac atttcatcat caagaattaa aatgttcatc
     6301 tttatctcct ttttgataag gaatctcata ccagacggtt gttccttgat ctgtactgtc
     6361 aaagtgtaac tgactagcac tgccataaag taaatttagg cgattgttta aattaacaag
     6421 ggctgttcct gttcccttgc tttcagatac agtttcctgt cctaatttgt caatcatatt
     6481 aggagaaata ccctgaccat tatcgctaac ggccaccttg taaaactctc cctgatctgt
     6541 tatggaaata caaatatgat tgtctttctt gcgttcttta aaagcatgac gcactgcatt
     6601 ttcaaccaaa acctgcaaac caaaaggagg cagggtcatt ttagttgaaa cagtaatatg
     6661 ataattcagt tgatatttat caggaaagcg cagcttttca agattcatat aagcatcaac
     6721 gtgcgctttt tcctgttcta aagtgatttc tctatcttgt ccgccttgta aactggttcg
     6781 gaaaaaagta cttaattgca tgagagcata tcgagctttg ttggcatcaa gacgaatcaa
     6841 agcactgatg gtgtttatgg cattgaagaa gaaatgagga ttaatctggg actgcaaggc
     6901 cttgatttct gcaatattag ccaacttatt ttgttcctcg gcaataccga tggccaattg
     6961 tccagaaaaa atttgtgcga gacctagggc aagattttct tcgacttcgg tcatcttctt
     7021 atcaccagaa aagtacattt ttaaggcccc aactgtctca ttattgatct tgagcggaac
     7081 gacgatggct gaattgagga gacagctttg gtctggacag gcaatggctg ttttatctaa
     7141 ggcaatttgt ggctgaccgt ttaaaataac actttttgag agatctgttt tgaccgcttg
     7201 tccggcaata tgatgatctt gaccaacgcc gatatgagct aggacattgg ttcgatcagt
     7261 cagaccaacg gcatcaaaat tagtatgctg cttaatgata ttacacactt tagtagctga
     7321 ttgctgactc agtccctgtc ttaaataagg cagggtttgc tgcgtcaaat ctaaaacatc
     7381 ccgagtctga acagctctca gctgtctttc attggataag taggtcttga gaatagctag
     7441 aaataaggtc gaacctagac tgttaagcaa catcatagga atgaaaatca gtttaaccaa
     7501 atcccagcca gtaaagaaac cgacaaagag catttgaata ctttcagcaa taatactgat
     7561 aacaatgacc tgcgaagtag atggataaag gttgttagtt tttaattgat cacccagtcg
     7621 accactaata tatcctacca aagcagaact gacaatgtaa aaagcaccag aaaaattccc
     7681 ttggaagaaa cgatggacac caccaatgaa acccacaaca gttccaacta aaggaccgcc
     7741 gactaagcta gccgttgtga taaccaaagt tctcgtatta gctagagaat ctgaatgaga
     7801 aatagtcgtt agaataggac gttccaccaa acttttatcg ctagtgattt caattcctgt
     7861 catattggaa atgatgacga aaataccaaa aatgataata agaaccagct tttcacgctt
     7921 agaacgttct tcaatcaact gtcgaaaata gctgttattg actagtaaaa atgccagaat
     7981 catgataata ccaagtctct gaaataataa tatcattaac atattgcgct tctcctatta
     8041 ttgaaatcca atacggacag ttacttatta gcaaaaaaag ctctttttcg aaatattttt
     8101 ttgatgacgt ctgtttctag ttttctattg taaacgtttt attttagatt ttcaagcttg
     8161 cttattttta aaagttactg gttagattgc catgaaaagg ttaggttgta tatatcatca
     8221 atttatattt ttctgtcatt ctccattctt atgaggagat aaatgaactg ctgctctcat
     8281 ttttctattt caaaaggaag tataaatttt cattttttgg tataataata acagctatat
     8341 taacggaaaa ggagccaaga taaagacagg cgaaagatca agaaaaacgg tcatttgttt
     8401 tagactttgg aacaggattc caagaatacc tttttccttt gtctttggtc tttatatgat
     8461 atttatgtca gattatttat cagtatcctc tttaaccaaa tatttaaaat taaaatttga
     8521 tcgcgatcct tatttggaac gagtttatct gacaggtcag gtttctaatt tcagaagacg
     8581 tcccaatcat cagtatttct cccttaaaga tgagaaagct gtcattcagg caaccatgtg
     8641 gagcggtatt tataggaaat tgggctttga gctcgaagaa ggcatgaaaa tcaatgttat
     8701 tggtcgtgtg caactgtatg aacctagtgg ttcttattcc atcatcattg aaaaggcaga
     8761 gccagatggt atcggtgcac tggctgttca gtttgaacaa cttaagaaaa aactggctga
     8821 ggctggttat tttgacgata ggcataaaca aagactgtcg cagtttgtta aaaagattgg
     8881 tgttgtcacc agtcctagtg gagcggttat tagagatatt atcacaacag tctcgcgtcg
     8941 ttttcccggt gtagatattt tactttttcc aaccaaagtt caaggtgaag gggcagcaca
     9001 ggaagtggct gacaatattc gtttggctaa tgaacgtact gatttagacc tgctcattgt
     9061 tggtcgtggt gggggttcta ttgaagatct ctgggctttt aatgaggaga ttgtagtgca
     9121 ggccattttt gaatcgcatc tgcccattat ttccagcgtt ggacatgaga cggatacaac
     9181 cttggctgat tttgcggcag atcgcagagc agcaacgcca acagcagcag ctgaattggc
     9241 aacacctgtg accaaggctg atttattagc ttttcttaaa gaaagacaga tgagatctta
     9301 tcaggctgtt atgcgtctga ttagacaaaa ggatgaacaa gttaagaaac tgcaaagatc
     9361 agttattttc agacagcctg aaagactcta tgatgcttat gttcaaaaat tggatcattt
     9421 aagaacacat ttgttgacca aggtgcggca ggtttatgat gtttatgata gcaaggaaca
     9481 tttgctgaga caaagattgt tgtcccttaa tttatcaggg tgtattcagc gctatcaagc
     9541 acaattaaaa caagatcagc gtttattgtt aagccacatg agcagccaat atgatagtaa
     9601 attagcccgt tttgaaaaag cacaagatgc gcttttgtca ctggatacga ctcggattgt
     9661 ggcgcgtggc tatgctattg ttcaaaaaga taatcacatt attcaatcaa cccaacagat
     9721 caaaaaagga gatcgcttgc atcttgaaat gaaagatggg caggtccaag tggaggtaga
     9781 aaatgtcaaa caagaagaaa acatttgaag aaaatttaca ggatttagaa gaaattgtga
     9841 accagttaga aaccggtgaa attcctcttg aagaagctat tactcaattc caaaaaggaa
     9901 tggcgctttc taaagatttg cagaaaacct tggagtctgc tgaaaagacc ttggtcaaag
     9961 tcatgcaggc tgatggcagt gaagcagaaa tggacgaatt gtgaaagata agattaaata
    10021 cattaatcag gctattaagc attattatgc gcaaactcat gtgtctcagg atttggttga
    10081 agcggtcttg tattctgttg ctgcaggcgg taaacggatt cgtcctctct tactattgga
    10141 aatcttgcaa ggctttggtt tggtacttac agaagctcac tatcaggtgg cagcaagtct
    10201 agagatgatt cataccggca gcctcgttca tgatgacctg cctgctatgg ataatgatga
    10261 ttataggcgg ggacagctga ccaatcataa gaaatttggt gaagcgacag ccatcttggc
    10321 aggtgacagt ctttttctag acccttttgg tttgctggcc aaggcggact taagggctga
    10381 tatcaagata aagttagtag cagaattgtc agatgctgca ggaagctatg gtatggtcgg
    10441 tgggcaaatg ttggatatta agggtgaaca tgttcaactc aatttagacc aactggctca
    10501 aattcatgcc aataagacag gaaaactctt gacttttcct tttgtagccg caggaataat
    10561 agcagaatta tcagaaaaag cccttgctcg gctccgtcag gtgggtgaat tagttggttt
    10621 ggcttttcaa gtacgtgatg atattttaga tgtgacagct agtttttcag aacttggtaa
    10681 gaccccacaa aaggatatcg aagctgataa atcaacctat cccagtcttt tgggcttgga
    10741 caagtcctat gccattttgg aagattctct caatcaagcg caagctattt tccaaaaatt
    10801 agctttagag gaacaattta atgctactgg aattgaaaca ataatagaaa ggttgcgtct
    10861 ccatgcctaa ggaaagagtg gatgttctag cctataaaca aggactgttt aacacaagag
    10921 aacaagccaa gcgaggtgtt atggcaggtt tggttgtcaa tgtcatcaat ggagaacgtt
    10981 atgataaacc cggcgagaaa attgatgaag cgactgagtt aaagttaaag ggagacaaat
    11041 taaaatatgt cagtcgcggc ggtttgaaat tggaaaaagc attaaaagtt tttgtcattt
    11101 cagtagatgg acagataact ttggacattg gcgcttcaac gggtggtttt acagacgtca
    11161 tgctgcaaaa tggtgctcaa ttagtctatg ctgttgatgt tggaaccaat cagttggtgt
    11221 ggaaattacg tcaagacgaa cgcgtctgca gcatggaaca gtacaatttc cgctatgcag
    11281 agcctagcga ttttgaacga ggacagccaa cttttgcttc cattgatgtg agttttattt
    11341 cactcaattt aatattacca gccttatcta agattttaac agatggtggt caagttgttg
    11401 ctttaattaa accgcagttt gaggcaggtc gtgaacagat tggtaaacat ggtattgtta
    11461 aggacaagtc agtccacgaa actgttttgg agacagtaac aacttttgcg acaaattacg
    11521 gattcacagt taaagaactt gatttttctc ccattcaggg cggtcatggt aatattgaat
    11581 ttttagccta cttagaaaaa tcagctcaag cccaaaatca agtcttgact aagattaaat
    11641 cgattgttga acaagcacat aaggaattta aaaagaatga agaaacgtga acgattagaa
    11701 ttaattaaaa aaattgtttt agaaaatgaa attgaaacac aaaaagaatt ggtcaaactt
    11761 ttagagaacg aaggcttaca agcaacgcaa gcgacaattt cccgtgatat taatgaggtc
    11821 ggtatcatta aagtaccagc ttcaaatggt cgctatattt atggcctttc taaggaaata
    11881 agcaaaaaag aagagtcaac accaaaacca gctgaaaaag cagttaagtt tatttcagat
    11941 caggtggcag gtttagagca tctcattcat attgatgttg ttcctggaaa tagctattta
    12001 ttgaaacgtt ttttactaga gagatttgaa ggacttattt ttagcttgct ggcagatgat
    12061 gacagtttgc ttttgattgt taaaaatgct aaagatagtg atagaattcg tcaagaaatc
    12121 aaatcttgga tggccaatta aatcataagg agtgggtatg cttttagaaa ttgccattaa
    12181 aaattttgct attattgaag aaatctcact caattttgaa aagggaatga ctgttctgac
    12241 cggtgaaaca ggtgcaggga agtctattgt cattgatgcc atgaatatga tgctaggcag
    12301 tagagccagc atagatgtta ttcgtcatgg cagtcctaaa gcagagattg agggtttttt
    12361 ctctgtggat aaaaatcctt ctttagagca gttactggct gatcagggaa ttgctttttc
    12421 agatgagcta atcattcgcc gtgagatttt acaaaatggg cgcagtatta gtcgtatcaa
    12481 tggtcaaatg gttaatctgg caactctgcg tgccgttggg cagtatttag ttgatattca
    12541 tggacagcat gatcaagaag aactgatgcg gccgcaaaag catattcagt tgttggatga
    12601 atttggtgat gaggtatttc aggtaagcaa gcagcattat caggacttat ttgatcgcta
    12661 tcggaactta cgtaagcgcg tcttgaataa acgtaagaat gagcaagaac atcaagcacg
    12721 tattgaaatg ctggagtatc agataggaga gattgaagca gcaaacttac aatctggtga
    12781 ggataccaag ctcttaaaac aacgtgataa acttatgaat cataagctta ttgttgatac
    12841 cttaaccaat gcttatgttt tacttgataa tgaagatttt tcgagtttga ccaatgttcg
    12901 ttcagctatg aatgatttgc agagtttgga agaatatgat gctgagtaca aggatttatc
    12961 caataatctc agcgaatctt actatatttt agaagatgtt agcaaacgtc tagagaccat
    13021 actggatcat atggattttg atgccaatac tttggttaaa cttgaagcac gtcttgatgt
    13081 tatcaacacc atcacgcgta agtatggtgg ttcagttgat gatgttttgg cttattttga
    13141 caatatcagt aaggaataca atcatttgac gggaaatgac cttgcttttg atgatatgga
    13201 aagagaacta aaagttttgg agcgctcact attagaagca gcagctcaat tgagtcaaaa
    13261 acgccatgcc attgcggaaa ccttgtctca ggagattaag caggaactaa aagatctcta
    13321 catggataag gctgatttta aagttgtttt tactaaagga aaatttaatc gcgagggaaa
    13381 tgaaacagtc gcttttcata tttcgactaa tcctggcgaa gactttaagc ctttggtcaa
    13441 agtcgcttct ggtggagagc tgtctcgcct catgttagcc attaagtcag ctttttcacg
    13501 tcgtgaagat aagactagca ttgtttttga tgaagttgat acaggtgttt caggacgtgt
    13561 cgcgcaggct attgctcaaa aaatttacaa aataggcaat cacggtcaag ttttagctat
    13621 ttcccatatc ccgcaagtca ttgccatcag tgattatcag tactttattg aaaaacaaag
    13681 cagcaaagcc acaactgtct caacggttcg ccttttaaat caagaggaaa gaattgaaga
    13741 aatcgctaag atgttggcag gggataatgt gacccaagct gcgcgccagc aagctaaaga
    13801 actattaaaa aaataagaga ttggtataga aagtatttta ataaatatgc tcttacttca
    13861 atctttttgt tttgatttgg actattgctt ctagtagaaa actattttaa actatcttaa
    13921 agtttaacag caaagtaatt ttaatccttt ctgtctttta aaattttccc taaatcttga
    13981 ttatttggta taataacaat actaatataa atttagaaaa gaaatgaagc aggataagaa
    14041 atgagtaaaa ttaaaattgt aactgattct tctattacaa tcgagcccga tttagttgaa
    14101 gcattggata tcactgttgt tcctttaacc gttatggttg acggcattgt ttattctgat
    14161 aacgatctta aggaagatgg gaaatttctt tctttaatgc gaaacagtaa gtcactccct
    14221 aaaacaagcc aaccacctgt tggtctgttc gcagaaactt atgaaaagct tattaaagag
    14281 ggggcggaac aaattgttgc tattcatatt acccattcct tatctggaac acttgaggcc
    14341 tcacgtcaag gagctaatat tgctggagca gatgtcactg tattagactc tgcctttaca
    14401 gatcaagcca tgaaatttca agttattgcg gctgctaaac tagctcaaaa gggtagcagt
    14461 ctagaagaaa ttttggcaag ggttgaagaa gtaaaaaaga aaaccgaact ttttattggt
    14521 gtctcaacct tagaaaatct ggttaaaggt ggacgaattg gccgtgtgac aggcttaatc
    14581 agttctcttc tcaatatcag agttgttatg gaactgaaaa accatgctct taatcctatt
    14641 gcgaaaggac gtggtaataa aacgtttaac aagtggctgg ataatttgat tgcgactatc
    14701 aaagaccgca aaattgctga gattggcatt tcctatgctg gggcttcaga ttttgctaat
    14761 ggtcttaaag acaagttaca ggcttatgtt gagaaagata ttgctgtttt agaaacgggg
    14821 tcaattattc agactcatac aggtgaaggt gcttttgcag taatggtgca ttatgagtaa
    14881 aaaaattcct aaaggacctg ctttctttct tgcaaatctt cttattttta gcttattatt
    14941 ttattttttt attccaacag cgaagttatc ttttaaaaat agcgatcaga aatcttcatt
    15001 aaacaaatct aaagcgacat cttttcacta tattgctatc ggtgactctt tgacacaagg
    15061 agtcggtgat acgactgatc aaggcggctt tattcccctt ttatcgcaag agttgaaatc
    15121 aaattatcac tataatgttt taagcagtaa ttatggtgtt tcaggcaata caagccagca
    15181 aattttgata cggatgcgaa aagagagaaa aattcaaaaa agtttgaata aggctaattt
    15241 aatgacctta acagttggtg gaaatgatgt tatgactgtt gttcgaaagg gattgacaaa
    15301 cttaaaagta tcttctttta ggcagccagc taaaacttat cagaagcatt tgcgaaaaat
    15361 tatccagatg gctagaagaa ggaataagga tctccccatt tatatcattg gtatttacaa
    15421 tccttattat ttaaatttcc ctaatatgac gcaaatgcag gatattattg acaattggaa
    15481 taagggaacg caaaaggttg tcgcagagta tagaaacgtt tattttgttc ccataaacga
    15541 tttactttat aaaggtgtta atggggagca aaaggctgtt ggaacatctg acagtgaggc
    15601 agagtcagga gaagtaacca atgatgccct ttctgaagga gatcgtttcc atcctaataa
    15661 tgttggttat caaatcatgt caaaagcaat aatggagaaa atcagtgaaa caaagaagaa
    15721 ctggaaataa aaaaaattgg tggaaatggg cttttctgct tttattagca ctcaatattg
    15781 ctttttgggg agtgattatc agtcgtgttt tgagcggtta ccattctaat acaataacaa
    15841 gtcaaacagt aaaaaatcct gttaaggttg gaacaattac gacaactaaa gaacaattga
    15901 atcagacctt ggcaagttat ttgaatgatt atcagtataa gggtatgacc tacagtgttc
    15961 aactaacttc aacaaacatt gaatttcaag gaacttataa acttctaggt tataacgtac
    16021 ctctttatat ctattttgaa ccttatcagt taaaaagcgg agctgtccag cttaaagtga
    16081 cttccttttc agtaggcaat cttcctctgc cagcatcaga ggttcttagt tatattaaat
    16141 caagttacaa actgccaaat tttgttgatg ttattccaga gaagtctgtt gttaatatca
    16201 atttgcaaaa aatagacaat gatgcaggca tttatttaaa gtcaacagct ataaatttgg
    16261 ttagtgatga aataaacttt gatattttaa agaaaaaacg ttaaaatggc attaaatact
    16321 tgacctatct aagtttttta ggtaagatag aacctgttaa agcctataaa ggcttataaa
    16381 aatattggag gatttgttaa atggctaaca aacaagattt gattgcaaaa gtagcagaag
    16441 ctactgaatt gactaagaaa gattcagctg cagcagtaga cgctgtcttc tcagcagtat
    16501 catcttacct tgcaaagggt gaaaaagtac aacttattgg ttttggtaac tttgaagttc
    16561 gcgaacgtgc agcacgcaaa ggtcgcaacc ctcaaacagg tgaagaaatc aaaatcaaag
    16621 cttctaaagt tccagcattc aaagctggta aagctcttaa agacgctgta aaataagatt
    16681 ttggcaaatg tacttttcta aatttaatct ttagatttta gagtgtacaa acgtttctgt
    16741 actgacccca aaaagttgga caagaaatta ttgaaaggac tcagtcctgt attgcacagg
    16801 actgagtcct tttagttttg tcttgattcg tttattgttg tagtcaaaaa tgtagttagt
    16861 gatggctttt tcaagtttgt cgagcgattt gaaagacttt tcatatacgt taatttcatc
    16921 aaaaaacacc ccaattgtta gattttctgc ccaactttta gggtgcaggt cagtttgcta
    16981 tggtcttttt aatgttctat tagcatgttt tcttttacag tgagtgctac cataatactt
    17041 gtttgctact tcccgttcta gctgtgtcat atagctaagt tataataata gcagattatt
    17101 ttttcacagt aatataatct tttaaatttc gacgaggacc aacattttta ccataactgt
    17161 taacataacc tactcgtaaa attaattgaa caggttgtga tttacctaaa ttctgctgca
    17221 acttttgatt ataggaggga atttcaatca tggcactaat cggttgaact gcaatgttat
    17281 ttctaacaca atcataccag aaagcttgcg atttttcacc aacagcaatc catttagaaa
    17341 tattctgttc acctgtaatt acaaaaaaac ctgcgcagtt ctctacttga ttaattaaag
    17401 tgttcttact ctgtttgaca aaattattac tcgtggcatt cttatgatta cttgttagat
    17461 aataaaaggt tttaattata ggatttaacc ctaacatatc accagagata ccatcttgtt
    17521 ttttcttagc ttcctgatta gaaaaacgca accattttcc ctgttctttt aaaaaatctt
    17581 gacttttata ctgtttagca gccgccgcga gactcccttt ttgtagatat ttaaatgttt
    17641 tacttccctt agcatagtag taaacattat catatttttt aattaaactt gaaacgactg
    17701 ttctattaat tggttttttc tggaattttc ttttatcagt atgacgtttt tggatgatat
    17761 ccaattgttt attgttaatt ttattatttt ttagtttttg ataatttatc aatacaactt
    17821 gatatttgtt ttctttagaa ggagcaatat tagaaatgct aacattatat ccataagctt
    17881 cgaatgattt ttttagagat tgaatataac aaccaattga aatataaagt tctcgattat
    17941 ttgggtcaac gacatttaaa gaacgcttat tatttagaaa accccctaat ctcttttgct
    18001 taggatctaa attaactttc caactctgag tattatggga attagctgcg aaagaagcat
    18061 agtataacgc gtgttcgatg tctgaagaag ttctttctaa ttgaatatta gtttgggtat
    18121 tagcggtttt tccaatagta aaaataatgg ctcctacact aaaaagaata aataaaaagg
    18181 ctgctattgt tgtaataata acttttttct tcatgttcct ttatcctttc ttgtaacatg
    18241 ctaataaagt tagaaattct tcttctaaaa aggttttgtt atcaagacca agtaagcgat
    18301 aatattcttt tttgttttct gccatacgaa tgatacccga tagtgcactc cagaaaaaaa
    18361 gagttgattg gttaaaatct aattctgtct gaagatagtt taagtgaaca ccatcttcaa
    18421 taagtgtgtt aattaactga tttatatcta accctaattg gtaaatatct ctatatactt
    18481 gaggtgtttc tttagaggtc atatcaacat tgatatgacc aatcattccg tcaaaatata
    18541 ttggataggt ttcacatagt ttttgcaatg caaaacaaat ttttaaataa tttttctgcc
    18601 actcttcttg agtgcttggt tgaatctgaa taattttttc aatagtctcg taaagccatt
    18661 tggcatgttt ataaactaat gagaaaaaga tttcttcttt attttcaaaa taaacatata
    18721 aagttgcttt actatatcca gctaatttag caatattatc cattgttgta tcagtaatac
    18781 ctttactgat aaagagtgtg ttagcagcat ctgaaatatt tttacgatga atacgagcag
    18841 gttccttttt tcgtctcgcc ataagagatc ctcctataat taattaaact agcggtttaa
    18901 ttaattatag tatatttctt tcttttgtca attttaaaca tctttgtatt aattatccta
    18961 gagattgttt gaatgatttt tagagataaa attgatagac agttttttgc atatttttta
    19021 tcatttagga aaagtaaagg ctacttgatg atgctaggca ctaatttttc tgtatcttta
    19081 aaaatagtgt ataatagaaa aaaagaataa cgaaggagtc aaaaatggga ctgcattctc
    19141 ataataatga tccgaataag gatgtttatg atcatgtatt aacgcattta aaagaaaagc
    19201 atattcgtat tactaaaaca cgagaagctg ttatttctta tatgattaac tcccgccgtc
    19261 atccgagtgc agaacaaatt cataaggatc ttcttcctca gtatccaagt atgagtttag
    19321 caacggtcta taataatttg aaagtcctga ttgatgaagg ctttgttgtt gaattaaagc
    19381 taagcaatga taatacagct tattttgatt ttatggggca tcagcatttg catgttgttt
    19441 gtgagtcttg tggtaagatt actgattttg tagacactga tatttctcat atcaagcaag
    19501 aagcatataa gcagacaaat tatgtgatta cgagagcaca gcttttgatt tatggtattt
    19561 gtccagactg tcaaagcaag aaaactaaaa aagccgatta atttgcttat tgattatcta
    19621 gagagaaaac ttatcatatg ggaaatagga ggtgagtcat taaatgaaat ttattatcat
    19681 tgttttaata gtgttttcta ttgttaaaat cattagtatt atttgggtaa gtaaaataat
    19741 gaagccaaag ccgatgactc caaaagaaat tgaggagtat gatcgcaagg aagatcaaaa
    19801 agatggtttt gatttttaaa aagacctgac tgaggagatt ctcagtcagg tcttttggta
    19861 tacagaaata aaaagatttc tttaagccat agcattcagc ttaccacgaa agtcttccaa
    19921 ggtttcataa cctttttccg tcatgatggc ttttaactct ttagtaatac gtttgaaaat
    19981 ttgaggacct tcttgatgaa gagctgtccc gatttgaacc atgctggcgc cacagagaat
    20041 atgttcgaaa gcatcgcgac ctgttttgac accgccggtt ccgataattt ggatggaagg
    20101 gttgaggcgc ttgtaaaaag catgaacatt ggctagcgct gttggtttga cgtaatcgcc
    20161 accaatgcct ccaaagccat tttttggttt aatgacgacc gtttcatctt caataactaa
    20221 gccgtttcca atagaattaa tacaattaac aaatgtcaga gggtatttat tgaaaatagc
    20281 agctgcttga tcaaagtgta caatgtcaaa ataaggtggt aacttgatac ctagtggttt
    20341 agtgaagtaa gtgaaaactt ctgaaaggat ttggtccgtt gtttcaaaat cataggcgat
    20401 ttgtggttta ccgggaacat ttggacagga aagattgagt tccaccaaac cttgatattt
    20461 gctggcttca accatcttaa gaatggtatg ggtttcttct ggcgacatgc caactaggga
    20521 taaaaagtga tttttgctat cgggctgttt ttgcaattct gtgacatagt ctaaataata
    20581 gttaatacct agattaggca ggcccattga attaatagag cctaattttg tgtcagcata
    20641 gcggggttga gggtttcctg cacgttcttc tagcgtacca gtcttggtaa caaaagaacc
    20701 tgcttccgaa tgatcaatag ctgctaattc ttcacgtgtc atgcaataaa cccctgcagc
    20761 attcatgaga caattatcaa agtcaaaaga gccaattgtt gtatgagttg aaaccatgga
    20821 acctccaaaa taatgaattt tttctattgt aacactagat aaggtcaacc
//
