GCF_027677975.1 - 18 region(s)

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Location: 286,406 - 327,824 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

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Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

PGW53_RS01555: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS01575: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS01610: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase

PGW53_RS01560: aminotransferase

smcogs: SMCOG1019: aminotransferase

PGW53_RS01660: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase lyase

PGW53_RS01570: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

PGW53_RS01650: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

PGW53_RS01655: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease

PGW53_RS01600: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.98	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.52	saccharide	O-antigen	Escherichia coli
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000773.3	0.51	saccharide	lipopolysaccharide	Escherichia coli
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.98	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.52	saccharide	O-antigen	Escherichia coli
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000773.3	0.51	saccharide	lipopolysaccharide	Escherichia coli
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.87 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.26 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.21 out of 28.19

Confidence: medium

Additional weak hits (8):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.18 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.09 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAQEMJ010000010.1 - Region 1 - NRPS

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Location: 1 - 27,975 nt. (total: 27,975 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

PGW53_RS12480: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

PGW53_RS12495: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

PGW53_RS12510: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

PGW53_RS12525: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Ligases: synthase

PGW53_RS12485: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.30 out of 27.78

Confidence: medium

Additional weak hits (8):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.06 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.17 out of 31.73

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 27975:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS12435: Glu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator

NZ_JAQEMJ010000010.1 - Region 2 - azole-containing-RiPP

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Location: 33,603 - 63,339 nt. (total: 29,737 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: glucosidase hydrolase

PGW53_RS12665: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

PGW53_RS12680: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: dehydratase

PGW53_RS12650: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Translocases: permease

PGW53_RS12580: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002311.3	0.51	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000606.5	0.49	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000605.5	0.46	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000607.5	0.45	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000565.5	0.44	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001640.3	0.43	ribosomal	kocurin	Kocuria rosea
BGC0000613.5	0.43	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002311.3	0.51	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000606.5	0.49	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000605.5	0.46	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000607.5	0.45	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000565.5	0.44	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001640.3	0.43	ribosomal	kocurin	Kocuria rosea
BGC0000613.5	0.43	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.62 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.40 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_JAQEMJ010000010.1 - Region 3 - lanthipeptide-class-iii

BGC0002111.3 (EVG22_32245):

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Location: 135,918 - 158,533 nt. (total: 22,616 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

PGW53_RS13085: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: methyltransferase

PGW53_RS13090: methyltransferase

smcogs: SMCOG1248: methyltransferase

Hydrolases: hydrolase

PGW53_RS13060: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Translocases: permease

PGW53_RS13065: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.82	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.60	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000528.5	0.53	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000551.5	0.51	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.4	0.50	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002701.2	0.49	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0000553.3	0.49	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000513.3	0.49	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.82	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.60	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000528.5	0.53	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000551.5	0.51	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.4	0.50	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002701.2	0.49	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0000553.3	0.49	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000513.3	0.49	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PGW53_RS13100

PGW53_RS13095

Leader:

MNDVLELQKLEKETDGKGIAV

Core:

DATITTTWTVTTTSGFVSSVSNHC

Core with dehydrations:

DADhbIDhbDhbDhbWDhbVDhbDhbDhbDhaGFVDhaDhaVDhaNHCys

antiSMASH-DB 4.0 matches for PGW53_RS13095

100.0%

NC_022081.1and 19 others:

NZ_CP016913.1 Lanthipeptides: BARD7_RS19060_lanthipeptideNZ_CP022654.2 Lanthipeptides: CHN56_RS21570_lanthipeptideNZ_CP032144.1 Lanthipeptides: D3C60_RS19850_lanthipeptideNZ_CP034203.1 Lanthipeptides: EBA29_RS19705_lanthipeptideNZ_CP040378.1 Lanthipeptides: D1120_RS19620_lanthipeptideNZ_CP068563.1 Lanthipeptides: JKJ03_RS01160_lanthipeptideNZ_CP069391.1 Lanthipeptides: JR311_RS02265_lanthipeptideNZ_CP073635.1 Lanthipeptides: KEF49_RS01155_lanthipeptideNZ_CP083764.1 Lanthipeptides: LAZ98_RS01175_lanthipeptideNZ_CP085388.1 Lanthipeptides: LIS75_RS01165_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS01075_lanthipeptideNZ_CP097586.1 Lanthipeptides: M8971_RS04245_lanthipeptideNZ_CP107556.1 Lanthipeptides: OF857_RS01165_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS01170_lanthipeptideNZ_JAGFPJ010000003.1 Lanthipeptides: J5M77_RS15590_lanthipeptideNZ_JAQEMJ010000010.1 Lanthipeptides: PGW53_RS13095_lanthipeptideNZ_LMAG01000010.1 Lanthipeptides: ASQ47_RS20350_lanthipeptideNZ_PVRP01000003.1 Lanthipeptides: C6355_RS19570_lanthipeptideNZ_SUKE01000008.1 Lanthipeptides: FAZ22_RS20105_lanthipeptide

Lanthipeptides: BASU_RS20300_lanthipeptide

1

DATITTTWTVTTTSGFVSSVSNHC

24

DATITTTWTVTTTSGFVSSVSNHC

1

DATITTTWTVTTTSGFVSSVSNHC

24

95.8%

NZ_JALAQD010000016.1and 1 other:

NZ_JALAUL010000008.1 Lanthipeptides: MOE42_RS14800_lanthipeptide

Lanthipeptides: MOD08_RS18745_lanthipeptide

2

ATITTTWTVTTTSGFVSSVSNHC

24

ATITTTWTVTTTSGFVSSVSNHC

1

ATITTTWTVTTTSGFVSSVSNHC

23

50.0%

NZ_FOHE01000012.1and 1 other:

NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20540_lanthipeptide

Lanthipeptides: BMX40_RS20545_lanthipeptide

7

TWTVTTTSGFVSSVSNHC

24

TWTVT F+S+VSNHC

4

TWTVTI---FLSTVSNHC

18

with 10 more sequence matches

37.9%

NZ_CP089924.1:

Lanthipeptides: LVB77_RS02735_lanthipeptide

9

TVTTTSGFVSSVSNHC

24

+V TSG SSVSNHC

5

SVNCTSG--SSVSNHC

18

37.5%

NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

5

TTTWTVTTTSGFVSSVSNHC

24

T WT+ TT S++SN C

1

TAGWTLLTTLIGTSTISNSC

20

34.5%

NZ_CP025227.1:

Lanthipeptides: allorf_0999194_0999376_lanthipeptide

8

WTVTTTS--GFVSSVSNHC

24

WTV TTS G V ++S C

2

WTVPTTSTIGLVCTLSWEC

20

33.3%

NZ_WEHU01000003.1and 3 others:

NZ_WEHU01000003.1 Lanthipeptides: F9279_RS25000_lanthipeptideNZ_WEHU01000003.1 Lanthipeptides: F9279_RS24995_lanthipeptideNZ_WEHU01000003.1 Lanthipeptides: F9279_RS24990_lanthipeptide

Lanthipeptides: F9279_RS25005_lanthipeptide

16

FVSSVSNHC

24

FVSS+SNHC

15

FVSSISNHC

23

25.0%

NZ_BBYG01000022.1:

Lanthipeptides: AOQ37_RS40945_lanthipeptide

18

SSVSNHC

24

SS+SNHC

4

SSISNHC

10

25.0%

NZ_CP014806.1and 3 others:

NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide

Lanthipeptides: ATY39_RS17980_lanthipeptide

16

FVSSVSNHC

24

F S++SNHC

15

FASTISNHC

23

25.0%

NZ_CP018933.1and 24 others:

NZ_CP018933.1 Lanthipeptides: BEI49_RS29525_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29520_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29515_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29510_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29505_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29500_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29495_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29490_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29485_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29480_lanthipeptideNZ_CP018933.1 Lanthipeptides: BEI49_RS29475_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04325_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04320_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04315_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04310_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04305_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04300_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04295_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04290_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04285_lanthipeptideNZ_CP085399.1 Lanthipeptides: LIS81_RS04280_lanthipeptideNZ_NTVN01000027.1 Lanthipeptides: CN415_RS28750_lanthipeptideNZ_PJCU01000036.1 Lanthipeptides: CWE34_RS31080_lanthipeptideNZ_PJCU01000036.1 Lanthipeptides: CWE34_RS31075_lanthipeptide

Lanthipeptides: BEI49_RS29530_lanthipeptide

16

FVSSVSNHC

24

+ S+VSNHC

14

WASTVSNHC

22

25.0%

NZ_GL545262.1:

Lanthipeptides: HMPREF0798_RS11830_lanthipeptide

9

TVTTTSGFVSSVSNHC

24

+++T F+S++S HC

1

SISTLVAFLSTISQHC

16

21.2%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

4

ITTTWTVTTTSGFVSS

19

+ TT +T SG++SS

6

LATTGALTAVSGYISS

21

17.4%

NZ_QVFA01000004.1:

Lanthipeptides: DW882_RS14120_lanthipeptide

5

TTTWTVTTTSGFVSSVSN

22

TTT ++ S VS++SN

14

TTTAIISAISSVVSAISN

31

MIBiG 4.0 matches for PGW53_RS13095

37.5%

Lanthipeptide: andalusicin A or andalusicin B

9

TVTTTSGFVSSVSNHC

24

TVTTT + S++SN+C

8

TVTTTGAWASTISNNC

23

37.5%

BGC0002111.3 (multiple genes):

Lanthipeptide: andalusicin A or andalusicin B

9

TVTTTSGFVSSVSNHC

24

TVTTT + S++SN+C

8

TVTTTGVWASTISNNC

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.12 out of 26.06

Confidence: medium

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.01 out of 30.22

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.61 out of 30.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.87 out of 33.73

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.07 out of 32.93

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.53 out of 21.55

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PGW53_RS13095 - Class III

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 2299.2 Da

Molecular weight: 2300.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2318.5 Da N = 1; 2336.5 Da N = 2; 2354.5 Da N = 3; 2372.5 Da N = 4; 2390.6 Da N = 5; 2408.6 Da N = 6; 2426.6 Da N = 7; 2444.6 Da N = 8; 2462.6 Da N = 9; 2480.7 Da N = 10; 2498.7 Da N = 11

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator
MogR	Repressor of flagellar motility genes

NZ_JAQEMJ010000011.1 - Region 1 - terpene-precursor

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Location: 24,002 - 44,892 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

PGW53_RS13440: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

PGW53_RS13405: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

PGW53_RS13410: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

PGW53_RS13410: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_JAQEMJ010000012.1 - Region 1 - NRPS

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Location: 1 - 25,218 nt. (total: 25,218 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

PGW53_RS14330: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase

PGW53_RS14245: aminotransferase

smcogs: SMCOG1019: aminotransferase

PGW53_RS14250: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

PGW53_RS14240: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

PGW53_RS14230: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

PGW53_RS14235: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (6):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 25218:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS14235: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_JAQEMJ010000013.1 - Region 1 - RRE-containing

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Location: 1 - 10,210 nt. (total: 10,210 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002713.2	0.24	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000329.5	0.23	NRPS	corpeptin A, corpeptin B	Pseudomonas corrugata
BGC0001005.5	0.23	NRPS, PKS	locillomycin, locillomycin B, locillomycin C	Bacillus subtilis
BGC0000367.5	0.22	NRPS	gramicidin	Brevibacillus brevis NBRC 100599
BGC0001207.5	0.22	NRPS	teixobactin	Eleftheria terrae
BGC0000350.5	0.21	NRPS	ET-743	uncultured organism
BGC0001389.5	0.19	NRPS	cichopeptin A, cichopeptin B	Pseudomonas cichorii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002713.2	0.24	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000329.5	0.23	NRPS	corpeptin A, corpeptin B	Pseudomonas corrugata
BGC0001005.5	0.23	NRPS, PKS	locillomycin, locillomycin B, locillomycin C	Bacillus subtilis
BGC0000367.5	0.22	NRPS	gramicidin	Brevibacillus brevis NBRC 100599
BGC0001207.5	0.22	NRPS	teixobactin	Eleftheria terrae
BGC0000350.5	0.21	NRPS	ET-743	uncultured organism
BGC0001389.5	0.19	NRPS	cichopeptin A, cichopeptin B	Pseudomonas cichorii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.63 out of 26.85

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

Additional weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.85 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.47 out of 29.38

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 2 - 70; Score: 34.6

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JAQEMJ010000013.1 - Region 2 - cyclic-lactone-autoinducer,lanthipeptide-class-ii

Download region SVG

Location: 88,228 - 117,486 nt. (total: 29,259 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

PGW53_RS15405: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

PGW53_RS15455: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

PGW53_RS15470: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002663.2	1.04	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000517.4	0.57	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.43	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000504.5	0.42	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.42	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000497.3	0.39	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001311.5	0.37	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0001391.3	0.34	ribosomal	thusin	Bacillus thuringiensis serovar rongseni

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002663.2	0.95	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000623.3	0.66	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000517.4	0.65	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000504.5	0.61	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.56	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000499.3	0.55	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002110.3	0.54	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000521.3	0.53	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PGW53_RS15455

PGW53_RS15460

Leader:

MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA

Core:

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

Core with dehydrations:

ADVDhbPHDhbDhbPDhaDhaLPCysGVFVDhbAAFCysPDhaDhbKCysDhbDhaDhaCys

antiSMASH-DB 4.0 matches for PGW53_RS15460

100.0%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

78.1%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCG VTA +CPS CTS C

1

ADVTPHTTPSSLPCGTLVTAVWCPSNACTSDC

32

65.6%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTPSS+ CG+ V+A FCP+TKCTS C

1

GDVDPQTTPSSVACGIAVSALFCPTTKCTSQC

32

with 123 more sequence matches

Only the first 10 are displayed here.

55.3%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

DVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS C GV V+A+ CP+TKCTS C

2

DVNPETTPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

53.1%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+TKCTS C

1

GDVNPETTPAT-PTIVAVSLGICPTTKCTSKC

31

53.1%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CGV +AAFCPST CTS C

5

TTSSWICGV-ASAAFCPSTACTSKC

28

53.1%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide

Lanthipeptides: C8268_RS00150_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CG FVTAA CPST CT C

8

TTSSWICG-FVTAALCPSTACTGDC

31

51.3%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

1

ADVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS PC V ++A CP+TKCTS C

2

GDVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

51.3%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

1

ADVTPHTT---PSSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TT SS C GV V+A+ CP+TKCTS C

2

GDVNPETTILTTSSWTCITAGVTVSASLCPTTKCTSQC

39

48.6%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

ADVTPHTTPSS---LPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ + + VTA+ CP+TKCTS C

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTSRC

35

46.9%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV+P TTP++ V ++ CP+TKCTS C

1

GDVSPETTPATPTIVVAISVGLCPTTKCTSKC

32

46.9%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide

Lanthipeptides: E4J16_RS14990_lanthipeptide

7

TTPSSLPCGVFVTAAFCPSTKCTSSC

32

TTPSS PCG+ +T CP+ CTS C

2

TTPSSWPCGIGITTTICPTAVCTSKC

27

46.9%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+ CT SC

1

GDVNPETTPAT-PTIVAVSVKLCPTGVCTKSC

31

MIBiG 4.0 matches for PGW53_RS15460

35.1%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

16

VFVTAAFCPSTKCTSSC

32

V V+AAFCP+TKCTS C

21

VGVSAAFCPTTKCTSRC

37

28.1%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: birimositide

22

FCPSTKCTSSC

32

FCP+TKCTS C

16

FCPTTKCTSKC

26

11.8%

Lanthipeptide: nocathioamide A

8

TPSSLPC

14

T SSLPC

42

TLSSLPC

48

PGW53_RS15465

Leader:

MTKQEKAAIYRDVNKHSELGLESPVGEVNEEELKNLAGA

Core:

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

Core with dehydrations:

KNVNQEEPLDhaDhaFIPGPGDhbCysLDhbAAICysPDhbDhbGMCysNIY

antiSMASH-DB 4.0 matches for PGW53_RS15465

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13810_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide

Lanthipeptides: BAMY6639_RS13810_lanthipeptide

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

82.4%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: allorf_0557723_0557881_lanthipeptide

Lanthipeptides: allorf_0557723_0557881_lanthipeptide

2

NVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

NV Q E SSFIPGPGTCLTAAICPTTGMCN Y

2

NVAQNETHSSFIPGPGTCLTAAICPTTGMCNKY

34

34.3%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

2

NVNQEE-PLSSFIPGPGTCLTAAICPTT

28

+VN E P + I G +TA++CPTT

2

DVNPETTPATPTIIGATIAVTASLCPTT

29

with 6 more sequence matches

24.3%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

5

QEEPLSSFIPGPGTC--LTAAICPTTG

29

++ LS P G+C ++ A CPT+

3

EQNSLSPLTPSSGSCVAISLAFCPTSA

29

23.5%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

20

LTAAICPTTGMCNIY

34

++AAICPTT +I

14

ISAAICPTTQCASIV

28

21.4%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

10

SSFIPGPGTCLTAAICPTT

28

++++ T TAAICPTT

18

TAWVCATVTLATAAICPTT

36

20.9%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

18

TCLTAAICPTT

28

T TAAICPTT

27

TLATAAICPTT

37

18.6%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

21

TAAICPTT

28

TAAICPTT

30

TAAICPTT

37

17.6%

NZ_BBZF01000020.1:

Lanthipeptides: LPU43_RS18755_lanthipeptide

14

PGPGTCLTAAICPTTGM

30

PGP + + +CP + M

4

PGPASNASVVLCPISVM

20

MIBiG 4.0 matches for PGW53_RS15465

16.2%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

LTAAICPTT

28

++AA CPTT

23

VSAAFCPTT

31

11.8%

Lanthipeptide: birimositide

24

ICPTT

28

CPTT

16

FCPTT

20

PGW53_RS15475

Leader:

MSIIETWKNPALRMNSQVVNPAGDLMEELSDDEMEMLAGG

Core:

CAWYDISCKLGNKGAWCTLTVECQSSCN

Core with dehydrations:

CysAWYDIDhaCysKLGNKGAWCysDhbLDhbVECysQDhaDhaCysN

antiSMASH-DB 4.0 matches for PGW53_RS15475

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYDISCKLGNKGAWCTLTVECQSSCN

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

85.7%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYD+SC+LGNKGAWCTLTVECQ++CN

1

CAWYDVSCRLGNKGAWCTLTVECQNNCN

28

75.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C WY+ISC+LGNKG WCTLT ECQ SC

1

CEWYNISCQLGNKGQWCTLTKECQRSC

27

with 101 more sequence matches

Only the first 10 are displayed here.

71.9%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

65.5%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ SCN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

62.1%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ +CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

60.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

3

WYDISCKLGNKGAWCTLTVECQSSCN

28

W+++S LGNKG CTLT ECQS CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

57.1%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY ++S LGN+G++CTLT ECQ+ CN

1

GWYSEMSAALGNRGSYCTLTKECQACCN

28

57.1%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY D+S LGN+G++CT+T ECQ+ CN

1

GWYADLSASLGNRGSYCTITKECQACCN

28

57.1%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

2

AWYDISCKLGNKGAWCTLTVECQSSCN

28

W D+S LGNKG CTLT ECQ C

2

GWKDLSKSLGNKGYVCTLTKECQKLCR

28

56.7%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGNKG WCTLT ECQ SCN

6

FTLSDYLGNKGGWCTLTKECQRSCN

30

55.2%

NZ_CP036016.1:

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C W+D+SC LGN G+ CTL+VEC+ +C

2

CTWWDLSCHLGNDGSTCTLSVECRPAC

28

53.6%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

6

ISCKLGNKGAWCTLTVECQSSCN

28

+S KLGN G CTLT ECQ CN

5

LSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for PGW53_RS15475

82.1%

Lanthipeptide: haloduracin β or haloduracin α

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

50.0%

Lanthipeptide: birimositide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGN G WCTLT ECQ +CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

20.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

17

CTLTVECQSSCN

28

CTL+ ECQ +CN

28

CTLSKECQPNCN

39

Lanthipeptide(s) for PGW53_RS15470

PGW53_RS15460

Leader:

MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA

Core:

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

Core with dehydrations:

ADVDhbPHDhbDhbPDhaDhaLPCysGVFVDhbAAFCysPDhaDhbKCysDhbDhaDhaCys

antiSMASH-DB 4.0 matches for PGW53_RS15460

100.0%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

78.1%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCG VTA +CPS CTS C

1

ADVTPHTTPSSLPCGTLVTAVWCPSNACTSDC

32

65.6%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTPSS+ CG+ V+A FCP+TKCTS C

1

GDVDPQTTPSSVACGIAVSALFCPTTKCTSQC

32

with 123 more sequence matches

Only the first 10 are displayed here.

55.3%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

DVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS C GV V+A+ CP+TKCTS C

2

DVNPETTPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

53.1%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+TKCTS C

1

GDVNPETTPAT-PTIVAVSLGICPTTKCTSKC

31

53.1%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CGV +AAFCPST CTS C

5

TTSSWICGV-ASAAFCPSTACTSKC

28

53.1%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide

Lanthipeptides: C8268_RS00150_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CG FVTAA CPST CT C

8

TTSSWICG-FVTAALCPSTACTGDC

31

51.3%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

1

ADVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS PC V ++A CP+TKCTS C

2

GDVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

51.3%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

1

ADVTPHTT---PSSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TT SS C GV V+A+ CP+TKCTS C

2

GDVNPETTILTTSSWTCITAGVTVSASLCPTTKCTSQC

39

48.6%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

ADVTPHTTPSS---LPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ + + VTA+ CP+TKCTS C

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTSRC

35

46.9%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV+P TTP++ V ++ CP+TKCTS C

1

GDVSPETTPATPTIVVAISVGLCPTTKCTSKC

32

46.9%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide

Lanthipeptides: E4J16_RS14990_lanthipeptide

7

TTPSSLPCGVFVTAAFCPSTKCTSSC

32

TTPSS PCG+ +T CP+ CTS C

2

TTPSSWPCGIGITTTICPTAVCTSKC

27

46.9%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+ CT SC

1

GDVNPETTPAT-PTIVAVSVKLCPTGVCTKSC

31

MIBiG 4.0 matches for PGW53_RS15460

35.1%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

16

VFVTAAFCPSTKCTSSC

32

V V+AAFCP+TKCTS C

21

VGVSAAFCPTTKCTSRC

37

28.1%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: birimositide

22

FCPSTKCTSSC

32

FCP+TKCTS C

16

FCPTTKCTSKC

26

11.8%

Lanthipeptide: nocathioamide A

8

TPSSLPC

14

T SSLPC

42

TLSSLPC

48

PGW53_RS15465

Leader:

MTKQEKAAIYRDVNKHSELGLESPVGEVNEEELKNLAGA

Core:

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

Core with dehydrations:

KNVNQEEPLDhaDhaFIPGPGDhbCysLDhbAAICysPDhbDhbGMCysNIY

antiSMASH-DB 4.0 matches for PGW53_RS15465

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13810_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide

Lanthipeptides: BAMY6639_RS13810_lanthipeptide

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

82.4%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: allorf_0557723_0557881_lanthipeptide

Lanthipeptides: allorf_0557723_0557881_lanthipeptide

2

NVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

NV Q E SSFIPGPGTCLTAAICPTTGMCN Y

2

NVAQNETHSSFIPGPGTCLTAAICPTTGMCNKY

34

34.3%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

2

NVNQEE-PLSSFIPGPGTCLTAAICPTT

28

+VN E P + I G +TA++CPTT

2

DVNPETTPATPTIIGATIAVTASLCPTT

29

with 6 more sequence matches

24.3%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

5

QEEPLSSFIPGPGTC--LTAAICPTTG

29

++ LS P G+C ++ A CPT+

3

EQNSLSPLTPSSGSCVAISLAFCPTSA

29

23.5%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

20

LTAAICPTTGMCNIY

34

++AAICPTT +I

14

ISAAICPTTQCASIV

28

21.4%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

10

SSFIPGPGTCLTAAICPTT

28

++++ T TAAICPTT

18

TAWVCATVTLATAAICPTT

36

20.9%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

18

TCLTAAICPTT

28

T TAAICPTT

27

TLATAAICPTT

37

18.6%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

21

TAAICPTT

28

TAAICPTT

30

TAAICPTT

37

17.6%

NZ_BBZF01000020.1:

Lanthipeptides: LPU43_RS18755_lanthipeptide

14

PGPGTCLTAAICPTTGM

30

PGP + + +CP + M

4

PGPASNASVVLCPISVM

20

MIBiG 4.0 matches for PGW53_RS15465

16.2%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

LTAAICPTT

28

++AA CPTT

23

VSAAFCPTT

31

11.8%

Lanthipeptide: birimositide

24

ICPTT

28

CPTT

16

FCPTT

20

PGW53_RS15475

Leader:

MSIIETWKNPALRMNSQVVNPAGDLMEELSDDEMEMLAGG

Core:

CAWYDISCKLGNKGAWCTLTVECQSSCN

Core with dehydrations:

CysAWYDIDhaCysKLGNKGAWCysDhbLDhbVECysQDhaDhaCysN

antiSMASH-DB 4.0 matches for PGW53_RS15475

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYDISCKLGNKGAWCTLTVECQSSCN

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

85.7%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYD+SC+LGNKGAWCTLTVECQ++CN

1

CAWYDVSCRLGNKGAWCTLTVECQNNCN

28

75.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C WY+ISC+LGNKG WCTLT ECQ SC

1

CEWYNISCQLGNKGQWCTLTKECQRSC

27

with 101 more sequence matches

Only the first 10 are displayed here.

71.9%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

65.5%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ SCN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

62.1%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ +CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

60.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

3

WYDISCKLGNKGAWCTLTVECQSSCN

28

W+++S LGNKG CTLT ECQS CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

57.1%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY ++S LGN+G++CTLT ECQ+ CN

1

GWYSEMSAALGNRGSYCTLTKECQACCN

28

57.1%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY D+S LGN+G++CT+T ECQ+ CN

1

GWYADLSASLGNRGSYCTITKECQACCN

28

57.1%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

2

AWYDISCKLGNKGAWCTLTVECQSSCN

28

W D+S LGNKG CTLT ECQ C

2

GWKDLSKSLGNKGYVCTLTKECQKLCR

28

56.7%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGNKG WCTLT ECQ SCN

6

FTLSDYLGNKGGWCTLTKECQRSCN

30

55.2%

NZ_CP036016.1:

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C W+D+SC LGN G+ CTL+VEC+ +C

2

CTWWDLSCHLGNDGSTCTLSVECRPAC

28

53.6%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

6

ISCKLGNKGAWCTLTVECQSSCN

28

+S KLGN G CTLT ECQ CN

5

LSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for PGW53_RS15475

82.1%

Lanthipeptide: haloduracin β or haloduracin α

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

50.0%

Lanthipeptide: birimositide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGN G WCTLT ECQ +CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

20.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

17

CTLTVECQSSCN

28

CTL+ ECQ +CN

28

CTLSKECQPNCN

39

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55

Confidence: medium

Additional weak hits (1):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PGW53_RS15460 - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 3016.4 Da

Molecular weight: 3018.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3036.4 Da N = 1; 3054.5 Da N = 2; 3072.5 Da N = 3; 3090.5 Da N = 4; 3108.5 Da N = 5; 3126.5 Da N = 6; 3144.6 Da N = 7

PGW53_RS15465 - Class II

Cleavage pHMM score: 3.70

RODEO score: 0

Monoisotopic mass: 3460.7 Da

Molecular weight: 3463.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3481.0 Da N = 1; 3499.0 Da N = 2; 3517.0 Da N = 3

PGW53_RS15475 - Class II

Cleavage pHMM score: 2.80

RODEO score: 0

Monoisotopic mass: 2992.3 Da

Molecular weight: 2994.4 Da

Number of bridges: 5

PGW53_RS15460 - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 3016.4 Da

Molecular weight: 3018.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3036.4 Da N = 1; 3054.5 Da N = 2; 3072.5 Da N = 3; 3090.5 Da N = 4; 3108.5 Da N = 5; 3126.5 Da N = 6; 3144.6 Da N = 7

PGW53_RS15465 - Class II

Cleavage pHMM score: 3.70

RODEO score: 0

Monoisotopic mass: 3460.7 Da

Molecular weight: 3463.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3481.0 Da N = 1; 3499.0 Da N = 2; 3517.0 Da N = 3

PGW53_RS15475 - Class II

Cleavage pHMM score: 2.80

RODEO score: 0

Monoisotopic mass: 2992.3 Da

Molecular weight: 2994.4 Da

Number of bridges: 5

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation

NZ_JAQEMJ010000016.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like

Download region SVG

Location: 14,366 - 66,157 nt. (total: 51,792 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

PGW53_RS16905: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS16955: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

PGW53_RS16960: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

PGW53_RS17010: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS17085: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase

PGW53_RS16910: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

PGW53_RS17025: isochorismatase

smcogs: SMCOG1027: isochorismatase

PGW53_RS17120: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

PGW53_RS17015: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

PGW53_RS17020: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGW53_RS17030: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	2.42	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	1.59	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.07	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.95	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	0.93	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.81	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.62 out of 18.16

Confidence: strong

Additional weak hits (16):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.13 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.81 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 14365 - 66157:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 14420 - 66157:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS17020: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

PGW53_RS17030: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAQEMJ010000002.1 - Region 1 - lanthipeptide-class-ii

Download region SVG

Location: 35,093 - 63,982 nt. (total: 28,890 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

PGW53_RS02955: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

PGW53_RS02975: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PGW53_RS02955

PGW53_RS02950

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for PGW53_RS02950

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for PGW53_RS02950

23.7%

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

BGC0000580.3 (EGD17355.1):

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

PGW53_RS02965

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for PGW53_RS02965

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for PGW53_RS02965

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

PGW53_RS02970

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for PGW53_RS02970

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for PGW53_RS02970

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

allorf_050414_050596

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_050414_050596

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_050414_050596

13.3%

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

Lanthipeptide(s) for PGW53_RS02975

PGW53_RS02950

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for PGW53_RS02950

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for PGW53_RS02950

23.7%

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

BGC0000580.3 (EGD17355.1):

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

PGW53_RS02965

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for PGW53_RS02965

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for PGW53_RS02965

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

PGW53_RS02970

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for PGW53_RS02970

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for PGW53_RS02970

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

PGW53_RS03015

Leader:

MINEQGAWSYAAQEVLGG

Core:

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

Core with dehydrations:

QHGENDhaVMMQKPFLRFKMMDhbFCysRLRFKPAENR

antiSMASH-DB 4.0 matches for PGW53_RS03015

100.0%

NZ_CP017775.1and 9 others:

NZ_CP023075.1 Lanthipeptides: allorf_1289301_1289462_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1371482_1371643_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2629421_2629582_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3178400_3178561_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_113041_113202_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0702092_0702253_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03015_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122870_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_335356_335517_lanthipeptide

Lanthipeptides: allorf_1372345_1372506_lanthipeptide

1

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

32

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

1

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

32

40.6%

NC_023073.1and 9 others:

NZ_CP016395.1 Lanthipeptides: BBJ33_RS20395_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21475_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19560_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19590_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20475_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06455_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06170_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06305_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19360_lanthipeptide

Lanthipeptides: U722_RS20000_lanthipeptide

1

QHGENSVMMQKPFLR

15

QHG+ SVMMQKPFLR

1

QHGDYSVMMQKPFLR

15

21.9%

NZ_JXCA02000027.1:

Lanthipeptides: allorf_403131_403280_lanthipeptide

10

QKPFLRFKMMTFC

22

Q PFLR + FC

12

QPPFLREGLCKFC

24

with 1 more sequence matches

15.2%

NZ_KB235948.1:

Lanthipeptides: OSC10802_RS0121020_lanthipeptide

15

RFKMMTFCRLRFKPAENR

32

RF C+ F PA+ R

11

RFMKAMLCKDSFSPADRR

28

PGW53_RS03045

Leader:

MCKLCGPKKVIVTETGFGA

Core:

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

Core with dehydrations:

VFHPCysPNCysKDhbGDhbDLDhbPVIKRLERMVQDAKARLDARV

antiSMASH-DB 4.0 matches for PGW53_RS03045

100.0%

NC_023073.1and 25 others:

NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide

Lanthipeptides: U722_RS20005_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

97.2%

NZ_CP025341.1:

Lanthipeptides: CXR48_RS19565_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLD RV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDLRV

36

89.7%

NZ_CP023075.1and 8 others:

NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20970_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide

Lanthipeptides: CK238_RS20695_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAK RLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

with 2 more sequence matches

22.2%

NC_015600.1and 17 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGILMTCAIK

22

22.2%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGALMTCPIK

22

MIBiG 4.0 matches for PGW53_RS03045

13.9%

Lanthipeptide: nisin A

6

PNCKTG

11

P CKTG

9

PGCKTG

14

allorf_050414_050596

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_050414_050596

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_050414_050596

13.3%

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.65 out of 24.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.07 out of 24.78

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.99 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PGW53_RS02950 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

PGW53_RS02965 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

PGW53_RS02970 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

allorf_050414_050596 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

PGW53_RS02950 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

PGW53_RS02965 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

PGW53_RS02970 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

PGW53_RS03015 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 3921.0 Da

Molecular weight: 3923.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3941.7 Da N = 1

PGW53_RS03045 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4023.2 Da

Molecular weight: 4025.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4043.7 Da N = 1

allorf_050414_050596 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_JAQEMJ010000002.1 - Region 2 - transAT-PKS

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Location: 209,976 - 298,201 nt. (total: 88,226 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

PGW53_RS03950: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS03960: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS03965: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS03975: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS04005: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase

PGW53_RS03845: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

PGW53_RS03945: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase phosphatase

PGW53_RS03925: hydrolase

smcogs: SMCOG1179: hydrolase

PGW53_RS03930: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

PGW53_RS03980: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

PGW53_RS03985: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

PGW53_RS04015: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

PGW53_RS04045: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: synthase

PGW53_RS03955: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

PGW53_RS03995: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.90	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.90	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 209975 - 298201:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: PGW53_RS03950 + PGW53_RS03955 + PGW53_RS03960 + PGW53_RS03965 + PGW53_RS03970 + PGW53_RS03975 + PGW53_RS03980

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS03945: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.6
inactive: 32.0
Methoxymalonyl-CoA: 28.0
Methylmalonyl-CoA: 20.8
Propionyl-CoA: 17.4
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_JAQEMJ010000003.1 - Region 1 - terpene

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Location: 93,921 - 114,661 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

PGW53_RS04765: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase

PGW53_RS04750: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

PGW53_RS04790: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

PGW53_RS04785: PT_phytoene_like

Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → squalene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.44 out of 20.97

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

Additional weak hits (6):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.57 out of 30.12

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR	NAD synthesis repressor
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_JAQEMJ010000003.1 - Region 2 - PKS-like

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Location: 197,374 - 238,618 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

KnownClusterBlast

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TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

PGW53_RS05430: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

PGW53_RS05385: aminotransferase

smcogs: SMCOG1019: aminotransferase

PGW53_RS05400: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: deacetylase

PGW53_RS05340: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

PGW53_RS05380: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

PGW53_RS05425: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

Additional weak hits (13):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAQEMJ010000032.1 - Region 1 - NRPS

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Location: 1 - 8,978 nt. (total: 8,978 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

PGW53_RS21535: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGW53_RS21545: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

PGW53_RS21550: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 8978:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val) + (Asp)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS21535: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (437..839): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PGW53_RS21545: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

NZ_JAQEMJ010000050.1 - Region 1 - lassopeptide

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Location: 1 - 2,832 nt. (total: 2,832 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

PGW53_RS22130: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	lassopeptide	Similarity score	Type	Compound(s)	Organism
BGC0000224.4		0.28	PKS	fredericamycin A	Streptomyces griseus

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000224.4		0.28	PKS	fredericamycin A	Streptomyces griseus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

Lasso peptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_JAQEMJ010000054.1 - Region 1 - NRPS

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Location: 1 - 1,566 nt. (total: 1,566 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

PGW53_RS22170: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000900.5	0.67	other (other)	ferrichrome	Aspergillus oryzae
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000900.5	0.67	other (other)	ferrichrome	Aspergillus oryzae
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	0.66	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 1566:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS22170: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (1..300): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

NZ_JAQEMJ010000008.1 - Region 1 - NRPS,betalactone,transAT-PKS

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Location: 72,034 - 158,757 nt. (total: 86,724 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

PGW53_RS10920: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

PGW53_RS10935: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS11030: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

PGW53_RS11050: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

PGW53_RS11125: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase

PGW53_RS11025: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

PGW53_RS11070: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

PGW53_RS11085: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

PGW53_RS11095: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

PGW53_RS11115: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

PGW53_RS11100: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

PGW53_RS11010: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

PGW53_RS11015: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGW53_RS11020: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

PGW53_RS11065: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

PGW53_RS11105: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

PGW53_RS11120: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGW53_RS11140: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	1.44	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	1.22	NRPS, PKS	iturin	Bacillus subtilis
BGC0002135.2	1.11	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	1.05	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000402.4	1.01	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001135.5	1.01	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	1.01	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.00	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.98	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.97	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	0.93	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	0.84	NRPS, PKS	iturin	Bacillus subtilis
BGC0000402.4	0.80	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5	0.77	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.76 out of 20.97

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.45 out of 26.33

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.12 out of 29.72

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

Additional weak hits (13):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.97 out of 30.22

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.66 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.90 out of 29.65

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.88 out of 29.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.25 out of 30.98

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.33 out of 26.85

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 72033 - 158757:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 72033 - 149283:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS11010: Ser - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1789..2188): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PGW53_RS11015: Tyr - Asn - Pro - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3286..3683): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4325..4732): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PGW53_RS11020: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 620.1
NH2: 18.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PGW53_RS11025: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 81.9
inactive: 31.2
Methoxymalonyl-CoA: 21.8
Methylmalonyl-CoA: 13.2
Propionyl-CoA: 12.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PGW53_RS11120: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ArgR	Regulator of arginine biosynthesis genes
CcpA	Catabolite control protein A
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAQEMJ010000009.1 - Region 1 - NRPS,T3PKS,transAT-PKS

Download region SVG

Location: 1 - 49,866 nt. (total: 49,866 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

PGW53_RS11390: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

PGW53_RS11495: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: acylase

PGW53_RS11425: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

PGW53_RS11430: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

PGW53_RS11435: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease

PGW53_RS11370: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

PGW53_RS11440: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

PGW53_RS11515: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: hydratase

PGW53_RS11405: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

PGW53_RS11410: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

PGW53_RS11395: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

PGW53_RS11400: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

PGW53_RS11415: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

PGW53_RS11490: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.90	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001758.4	0.90	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.89	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002274.2	0.89	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002154.2	0.89	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001132.4	0.89	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.89	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.89	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.89	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.88	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.64	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002274.2	0.63	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.50 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.56 out of 24.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78

Confidence: medium

Additional weak hits (11):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 49866:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid) + (mal)
Non-colinear ordering:: PGW53_RS11400 + PGW53_RS11395

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

PGW53_RS11400: fatty_acid - Gly

Search NORINE for peptide: strict or relaxed

CAL_domain (74..476): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 26.0
NH2: 9.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1145..1540): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

PGW53_RS11425: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 90.5
inactive: 31.8
Methoxymalonyl-CoA: 22.5
Methylmalonyl-CoA: 9.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PGW53_RS11430: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 35.4
inactive: 26.4
Methoxymalonyl-CoA: 14.9
Benzoyl-CoA: 14.0
Methylmalonyl-CoA: 9.2
Isobutyryl-CoA: 8.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PGW53_RS11435: mal

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 100.0
inactive: 46.8
Methoxymalonyl-CoA: 38.9
Methylmalonyl-CoA: 25.3
Propionyl-CoA: 23.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0