LOCUS       NZ_JAQEMJ010000010     27975 bp    DNA     linear   CON 22-FEB-2024
DEFINITION  Bacillus velezensis strain TM115-48 GF3HH28002B.Scaf10, whole genome
            shotgun sequence.
ACCESSION   NZ_JAQEMJ010000010
VERSION     NZ_JAQEMJ010000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus velezensis
  ORGANISM  Bacillus velezensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus amyloliquefaciens group.
REFERENCE   1  (bases 1 to 179705)
  AUTHORS   Lin,X., Hu,T., Chen,J., Liang,H., Zhou,J., Wu,Z., Ye,C., Jin,X.,
            Xu,X., Zhang,W., Jing,X., Yang,T., Wang,J., Yang,H., Kristiansen,K.,
            Xiao,L. and Zou,Y.
  TITLE     The genomic landscape of reference genomes of cultivated human gut
            bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 179705)
  AUTHORS   Zou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-2022) BGI Reaserch, BGI-Shenzhen, Beishan
            Industrial Zone, Shenzhen 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: MGI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/22/2024 04:06:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,454
            CDSs (total)                      :: 4,396
            Genes (coding)                    :: 4,263
            CDSs (with protein)               :: 4,263
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 23S)
            partial rRNAs                     :: 1, 1 (5S, 16S)
            tRNAs                             :: 49
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 133
            CDSs (without protein)            :: 133
            Pseudo Genes (ambiguous residues) :: 0 of 133
            Pseudo Genes (frameshifted)       :: 69 of 133
            Pseudo Genes (incomplete)         :: 78 of 133
            Pseudo Genes (internal stop)      :: 16 of 133
            Pseudo Genes (multiple problems)  :: 26 of 133
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:15:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 27975
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQEMJ010000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27975
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..27975
                     /SMILES="NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27975
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:7975](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..7975)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            complement(<1..7975)
                     /gene="srfAA"
                     /locus_tag="PGW53_RS12435"
     CDS             complement(<1..7975)
                     /GO_function="GO:1904091 - non-ribosomal peptide synthetase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Condensation_Starter (4-302). E-value:
                     7.6e-89. Score: 289.9. Matches aSDomain:
                     nrpspksdomains_PGW53_RS12435_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (465-867). E-value: 1e-112.
                     Score: 368.7. Matches aSDomain:
                     nrpspksdomains_PGW53_RS12435_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (976-1045). E-value: 3e-25. Score:
                     80.2. Matches aSDomain: nrpspksdomains_PGW53_RS12435_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1060-1346). E-value:
                     9.8e-106. Score: 345.0. Matches aSDomain:
                     nrpspksdomains_PGW53_RS12435_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1511-1908). E-value:
                     6.9e-105. Score: 342.9. Matches aSDomain:
                     nrpspksdomains_PGW53_RS12435_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2015-2083). E-value: 1.2e-29.
                     Score: 94.3. Matches aSDomain:
                     nrpspksdomains_PGW53_RS12435_PCP.2"
                     /NRPS_PKS="Domain: Condensation_LCL (2098-2384). E-value:
                     2.1e-105. Score: 343.9. Matches aSDomain:
                     nrpspksdomains_PGW53_RS12435_Condensation_LCL.2"
                     /codon_start=1
                     /gene="srfAA"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047: phosphopantetheine-binding domain-containing
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_057766256.1"
                     /locus_tag="PGW53_RS12435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="surfactin non-ribosomal peptide synthetase SrfAA"
                     /protein_id="WP_270354387.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-117, bitscore:
                     386.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 3.9e-94, bitscore:
                     308.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.7e-15, bitscore:
                     50.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITFYPLTNAQKRIWYTEKFYPNTSISNLAGFGKLISEDGVQAH
                     YVEKAIQEFVRRYESMRIRLRLDDEGEPVQYVSEYRPLSIGHTDIRQAGCSADELSKWG
                     REEAGKPLALYDQDLFRFSVHTISENEVWFYANVHHIISDGISMTILGNAITDIYLELS
                     GGTSEEQTEIPSFIEHVLTEQEYVQSKRFKKDRDFWNGQFETVPELVSLKRSQADAGLN
                     AKRFSQEIPHDLYGRIHSFCEEHKVSVLSLFQSALITYLYKVTGRDDVVTGTFMGNRTN
                     AKEKQMLGMFVSTVPVRTSVDGGQSFLEFVKGRMKDLMKILRHQKYPYNLLVNDLRASK
                     SSLSRLFTVALEYQVMQWQKKENLSFLTDPIFSGSGTNDISIHVKERWDTGKLTIDFDY
                     RSDIFKGEEIESVSERLITLIEDAISSPDRIIDELTLLSESEKERLLKRASGNPVNYRK
                     EMTIPGLFEEKVKSLSDKPAVVYEGRTLSYRTLHEQSGRIAGRLLQAGISADSPVAVLL
                     GRSECVIAAILGILKAGGAYVPIDPDFPADRIQYILEDSGAKAVLTEAGIQAPAADAER
                     IDFDEAVQYETAADGVGIQSDRLAYIIYTSGTTGRPKGVMIEHRQVHHLVQSLQQEIYQ
                     CGEQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKTTVTNGSALLDYYRQNRIEAT
                     DGTPAHLQMMVAAGDVSGIELRHMLIGGEGLSAAVAEQLMTLFHQSGRTPRLTNVYGPT
                     ETCVDASVHQVSADNGMNQQAAYVPIGKPLGNARLYILDKHQRLQPDGTAGELYIAGDG
                     VGRGYLNLPDLTAEKFLQDPFNGSGRMYRTGDMARWLPDGTIEYIGREDDQVKVRGYRI
                     ELGEIETVLRKAPGAAQAVVLARPDQQGSLDVCAYIVQEKGTEFHPAEYREYVSKHLPD
                     YMVPAYFTKTDEIPLTPSGKADRKKLFALDVQAVSSSEYAAPRNETEEMLTVIWQEVLG
                     MDKAGIYDHFFESGGHSLKAMTLLTKIHKQMGVEIPLQYLFEHPTIAALADYAENRNEG
                     PAFSAIEPAEKQASYPLSLAQQRTYIASQFEDAGVGYNMPAAAMIEGALDREKLERAFS
                     ALISRHEALRTSFQSEDGTPRQVIGEHVPFHIEMIEARGRTNEQVMKDFVRRFDLSEAP
                     LFRIGLQTLGHNRHLLLFDMHHLISDGVSISIMLKELADIYGGNQLPELRIQYKDYAVW
                     QAERAKEGYKKERAYWKEVFSGELPVLQLLPDYPRPQVQSFEGDRVSVKLPKMLRERLQ
                     KLAEKNGATLYMVLLSAYYTLLSKYSGQEDIIVGTPSAGRNHSDTEGLIGMFVNTLALR
                     SSVKQGQTFAGLLGHVRKQVLDAFSHQDYPFEWLTEELNVPRDMSRHPIFDTMFSLQNA
                     SDGIPEIGNLTLSLHETNFNIAKFDLTMQARETAEGIALDLDYCTKLFKRSTADRMLAH
                     YVRLLESAAAQPDAKISEYDLLSEREALTQLQQFNPERTVYPKEQTIVQIFEEQARKNP
                     DRTALQFEGETLSYQHLNERANRLARHILSVGGGGKTAAVLCERSMDMIVSIMAVLKAG
                     SAYVPIDPEHPVQRIQHFFRDSGANVLMTQQSLKPLAEKAGFQGVIVLADDEASYEKDS
                     RNPALPFDSKTIANLTYTSGTTGTPKGNIVTHANILRTVKNTNYLTVSEEDTVLGLSNY
                     VFDAFMFDMFGSLLNGAKLVIVPKDTVLDMSRLSRVIKRENVSILMITTALFHLLVDME
                     PSCLTTLRKIMFGGERASVEHVKKALAAVGKGRLLHMYGPSESTVFATYHPVDVIEEDT
                     LSVPIGKPVSNTEVFIMNSAGRIQPAGIAGELCVSGEGLVEGYYNRPELTEEKFVEHPF
                     KEGERMYKTGDLARWLPNGDIEFIGRIDHQVKIRGQRIELGEIEHQLQSHDQIQECIVL
                     AVDQGAGDKLLCAYVVGLREISSRELREHTAKDLPAYMIPSVFIQLDELPLTGNGKIDR
                     RALPMPDVTAANAVSYTAPRNETEQKLADIWAEVLQMERVGVHDQFFEIGGHSLAGMKL
                     LALIQKTFGVQLTLKDLFTSPTAAGLAQLIEGAERKAAESITPAAERETYPVSSPQKRM
                     FVLQQLEGAETSYNMPSVLRLKGKLDAEKLKSVMKQLTERHEAFRTTFDIKDGETVQRI
                     WAEADIDMEYYEASEEDAERIIQSFIRPFRLDQLPLVRTGLVKLAEHDHLLLFDMHHII
                     SDGASVGVLIDELSRLYGGETLEPLRIHYKDYAVWQQKFIQSEQYRKQEEHWLRELDGE
                     LPVLTLPADYSRPAVQTFEGDKLVFSLTKEQTSALRSLAKQTDSTMYMVLLASYSAFLS
                     KLSGQHDIIVGSPVAGRSHADLTNVIGVFVNTLALRTYPEADKTFTDYLKEVKQTALHA
                     FDAQDYPLEDLLQKVEVQRDTSRNPLFDAVFSMQNANAENLVMEGIELKHHPFDRKTAK
                     FDLTMTAEDTDEGLTFVLEYNTALFKPETAETWKHYWLQLLEAAAENPAAKLSELSLVN
                     ETEKQALLDEWKGKTISVPRDKTVHRLFEETAARYANRPAAAYNGAKWTYGELNARANR
                     IARILMDCGVTADERVGILTKPSLEMAAGVLGVLKAGAAFVPIDPDYPEERIIYILQDS
                     GAKLLLTQEALDVPDSY"
     CDS_motif       complement(98..139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0027"
                     /evalue="2.90E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2626"
                     /protein_start="2612"
                     /score="17.2"
                     /tool="antismash"
                     /translation="LGVLKAGAAFVPID"
     CDS_motif       complement(662..781)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0026"
                     /evalue="4.70E-13"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2438"
                     /protein_start="2398"
                     /score="41.4"
                     /tool="antismash"
                     /translation="KQTALHAFDAQDYPLEDLLQKVEVQRDTSRNPLFDAVFSM"
     aSDomain        complement(824..1681)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_Condensation_LCL.2
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.10E-105"
                     /label="PGW53_RS12435_Condensation_LCL.2"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2384"
                     /protein_start="2098"
                     /score="343.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="ETYPVSSPQKRMFVLQQLEGAETSYNMPSVLRLKGKLDAEKLKSV
                     MKQLTERHEAFRTTFDIKDGETVQRIWAEADIDMEYYEASEEDAERIIQSFIRPFRLDQ
                     LPLVRTGLVKLAEHDHLLLFDMHHIISDGASVGVLIDELSRLYGGETLEPLRIHYKDYA
                     VWQQKFIQSEQYRKQEEHWLRELDGELPVLTLPADYSRPAVQTFEGDKLVFSLTKEQTS
                     ALRSLAKQTDSTMYMVLLASYSAFLSKLSGQHDIIVGSPVAGRSHADLTNVIGVFVNTL
                     ALRTY"
     CDS_motif       complement(830..919)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0025"
                     /evalue="4.80E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2382"
                     /protein_start="2352"
                     /score="44.6"
                     /tool="antismash"
                     /translation="DIIVGSPVAGRSHADLTNVIGVFVNTLALR"
     CDS_motif       complement(1178..1210)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0024"
                     /evalue="3.90E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2266"
                     /protein_start="2255"
                     /score="13.1"
                     /tool="antismash"
                     /translation="HYKDYAVWQQK"
     CDS_motif       complement(1241..1306)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0023"
                     /evalue="2.50E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2245"
                     /protein_start="2223"
                     /score="32.8"
                     /tool="antismash"
                     /translation="MHHIISDGASVGVLIDELSRLY"
     CDS_motif       complement(1502..1615)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0022"
                     /evalue="2.80E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2158"
                     /protein_start="2120"
                     /score="42.2"
                     /tool="antismash"
                     /translation="TSYNMPSVLRLKGKLDAEKLKSVMKQLTERHEAFRTTF"
     aSDomain        complement(1727..1930)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_PCP.2"
                     /evalue="1.20E-29"
                     /label="PGW53_RS12435_PCP.2"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="2083"
                     /protein_start="2015"
                     /score="94.3"
                     /tool="antismash"
                     /translation="EQKLADIWAEVLQMERVGVHDQFFEIGGHSLAGMKLLALIQKTFG
                     VQLTLKDLFTSPTAAGLAQLIEG"
     aSModule        complement(1727..4795)
                     /complete
                     /domains="nrpspksdomains_PGW53_RS12435_Condensation_LCL.1"
                     /domains="nrpspksdomains_PGW53_RS12435_AMP-binding.2"
                     /domains="nrpspksdomains_PGW53_RS12435_PCP.2"
                     /locus_tags="PGW53_RS12435"
                     /monomer_pairings="Leu -> Leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2222..2287)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0021"
                     /evalue="4.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1918"
                     /protein_start="1896"
                     /score="38.0"
                     /tool="antismash"
                     /translation="FIGRIDHQVKIRGQRIELGEIE"
     aSDomain        complement(2252..3442)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_AMP-binding.2"
                     /evalue="6.90E-105"
                     /label="PGW53_RS12435_AMP-binding.2"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1908"
                     /protein_start="1511"
                     /score="342.9"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FEEQARKNPDRTALQFEGETLSYQHLNERANRLARHILSVGGGGK
                     TAAVLCERSMDMIVSIMAVLKAGSAYVPIDPEHPVQRIQHFFRDSGANVLMTQQSLKPL
                     AEKAGFQGVIVLADDEASYEKDSRNPALPFDSKTIANLTYTSGTTGTPKGNIVTHANIL
                     RTVKNTNYLTVSEEDTVLGLSNYVFDAFMFDMFGSLLNGAKLVIVPKDTVLDMSRLSRV
                     IKRENVSILMITTALFHLLVDMEPSCLTTLRKIMFGGERASVEHVKKALAAVGKGRLLH
                     MYGPSESTVFATYHPVDVIEEDTLSVPIGKPVSNTEVFIMNSAGRIQPAGIAGELCVSG
                     EGLVEGYYNRPELTEEKFVEHPFKEGERMYKTGDLARWLPNGDIEFIGRIDHQVKIR"
     CDS_motif       complement(2369..2458)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0020"
                     /evalue="5.20E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1869"
                     /protein_start="1839"
                     /score="41.2"
                     /tool="antismash"
                     /translation="PAGIAGELCVSGEGLVEGYYNRPELTEEKF"
     CDS_motif       complement(2573..2596)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0019"
                     /evalue="8.40E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1801"
                     /protein_start="1793"
                     /score="3.3"
                     /tool="antismash"
                     /translation="YGPSESTV"
     CDS_motif       complement(2966..3019)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0018"
                     /evalue="6.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1670"
                     /protein_start="1652"
                     /score="18.8"
                     /tool="antismash"
                     /translation="LTYTSGTTGTPKGNIVTH"
     CDS_motif       complement(3218..3259)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0017"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1586"
                     /protein_start="1572"
                     /score="15.6"
                     /tool="antismash"
                     /translation="MAVLKAGSAYVPID"
     CDS_motif       complement(3779..3898)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0016"
                     /evalue="1.30E-19"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1399"
                     /protein_start="1359"
                     /score="62.6"
                     /tool="antismash"
                     /translation="RKQVLDAFSHQDYPFEWLTEELNVPRDMSRHPIFDTMFSL"
     aSDomain        complement(3938..4795)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="9.80E-106"
                     /label="PGW53_RS12435_Condensation_LCL.1"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1346"
                     /protein_start="1060"
                     /score="345.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLISDG"
                     /tool="antismash"
                     /translation="ASYPLSLAQQRTYIASQFEDAGVGYNMPAAAMIEGALDREKLERA
                     FSALISRHEALRTSFQSEDGTPRQVIGEHVPFHIEMIEARGRTNEQVMKDFVRRFDLSE
                     APLFRIGLQTLGHNRHLLLFDMHHLISDGVSISIMLKELADIYGGNQLPELRIQYKDYA
                     VWQAERAKEGYKKERAYWKEVFSGELPVLQLLPDYPRPQVQSFEGDRVSVKLPKMLRER
                     LQKLAEKNGATLYMVLLSAYYTLLSKYSGQEDIIVGTPSAGRNHSDTEGLIGMFVNTLA
                     LRSSV"
     CDS_motif       complement(3947..4036)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0015"
                     /evalue="2.40E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1343"
                     /protein_start="1313"
                     /score="52.0"
                     /tool="antismash"
                     /translation="DIIVGTPSAGRNHSDTEGLIGMFVNTLALR"
     CDS_motif       complement(4289..4324)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0014"
                     /evalue="3.30E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1229"
                     /protein_start="1217"
                     /score="13.3"
                     /tool="antismash"
                     /translation="QYKDYAVWQAER"
     CDS_motif       complement(4355..4420)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0013"
                     /evalue="4.40E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1207"
                     /protein_start="1185"
                     /score="25.7"
                     /tool="antismash"
                     /translation="MHHLISDGVSISIMLKELADIY"
     CDS_motif       complement(4616..4723)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0012"
                     /evalue="1.10E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1120"
                     /protein_start="1084"
                     /score="49.9"
                     /tool="antismash"
                     /translation="YNMPAAAMIEGALDREKLERAFSALISRHEALRTSF"
     CDS_motif       complement(4754..4789)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0011"
                     /evalue="3.90E+01"
                     /label="C1_starter_004-017"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1074"
                     /protein_start="1062"
                     /score="-1.4"
                     /tool="antismash"
                     /translation="YPLSLAQQRTYI"
     aSDomain        complement(4841..5047)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_PCP.1"
                     /evalue="3.00E-25"
                     /label="PGW53_RS12435_PCP.1"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="1045"
                     /protein_start="976"
                     /score="80.2"
                     /tool="antismash"
                     /translation="EEMLTVIWQEVLGMDKAGIYDHFFESGGHSLKAMTLLTKIHKQMG
                     VEIPLQYLFEHPTIAALADYAENR"
     aSModule        complement(4841..7963)
                     /complete
                     /domains="nrpspksdomains_PGW53_RS12435_Condensation_Starter
                     .1"
                     /domains="nrpspksdomains_PGW53_RS12435_AMP-binding.1"
                     /domains="nrpspksdomains_PGW53_RS12435_PCP.1"
                     /locus_tags="PGW53_RS12435"
                     /monomer_pairings="Glu -> Glu"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(5345..5410)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0010"
                     /evalue="7.60E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="877"
                     /protein_start="855"
                     /score="37.1"
                     /tool="antismash"
                     /translation="YIGREDDQVKVRGYRIELGEIE"
     aSDomain        complement(5375..6580)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_AMP-binding.1"
                     /evalue="1.00E-112"
                     /label="PGW53_RS12435_AMP-binding.1"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="867"
                     /protein_start="465"
                     /score="368.7"
                     /specificity="substrate consensus: Glu"
                     /tool="antismash"
                     /translation="FEEKVKSLSDKPAVVYEGRTLSYRTLHEQSGRIAGRLLQAGISAD
                     SPVAVLLGRSECVIAAILGILKAGGAYVPIDPDFPADRIQYILEDSGAKAVLTEAGIQA
                     PAADAERIDFDEAVQYETAADGVGIQSDRLAYIIYTSGTTGRPKGVMIEHRQVHHLVQS
                     LQQEIYQCGEQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKTTVTNGSALLDYYR
                     QNRIEATDGTPAHLQMMVAAGDVSGIELRHMLIGGEGLSAAVAEQLMTLFHQSGRTPRL
                     TNVYGPTETCVDASVHQVSADNGMNQQAAYVPIGKPLGNARLYILDKHQRLQPDGTAGE
                     LYIAGDGVGRGYLNLPDLTAEKFLQDPFNGSGRMYRTGDMARWLPDGTIEYIGREDDQV
                     KVR"
     CDS_motif       complement(5492..5581)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0009"
                     /evalue="5.90E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="828"
                     /protein_start="798"
                     /score="50.5"
                     /tool="antismash"
                     /translation="PDGTAGELYIAGDGVGRGYLNLPDLTAEKF"
     CDS_motif       complement(5705..5728)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0008"
                     /evalue="1.30E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="757"
                     /protein_start="749"
                     /score="5.6"
                     /tool="antismash"
                     /translation="YGPTETCV"
     CDS_motif       complement(6119..6178)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0007"
                     /evalue="7.70E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="619"
                     /protein_start="599"
                     /score="33.7"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGRPKGVMIEH"
     CDS_motif       complement(6353..6394)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0006"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="541"
                     /protein_start="527"
                     /score="18.4"
                     /tool="antismash"
                     /translation="LGILKAGGAYVPID"
     CDS_motif       complement(6917..7030)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0005"
                     /evalue="1.00E-11"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="353"
                     /protein_start="315"
                     /score="37.3"
                     /tool="antismash"
                     /translation="KDLMKILRHQKYPYNLLVNDLRASKSSLSRLFTVALEY"
     aSDomain        complement(7070..7963)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PGW53_RS12435_Condensation_Start
                     er.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="7.60E-89"
                     /label="PGW53_RS12435_Condensation_Starter.1"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="302"
                     /protein_start="4"
                     /score="289.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="FYPLTNAQKRIWYTEKFYPNTSISNLAGFGKLISEDGVQAHYVEK
                     AIQEFVRRYESMRIRLRLDDEGEPVQYVSEYRPLSIGHTDIRQAGCSADELSKWGREEA
                     GKPLALYDQDLFRFSVHTISENEVWFYANVHHIISDGISMTILGNAITDIYLELSGGTS
                     EEQTEIPSFIEHVLTEQEYVQSKRFKKDRDFWNGQFETVPELVSLKRSQADAGLNAKRF
                     SQEIPHDLYGRIHSFCEEHKVSVLSLFQSALITYLYKVTGRDDVVTGTFMGNRTNAKEK
                     QMLGMFVSTVPVRTSVD"
     CDS_motif       complement(7082..7171)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0004"
                     /evalue="2.70E-11"
                     /label="C5_starter_265-294"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="298"
                     /protein_start="268"
                     /score="35.8"
                     /tool="antismash"
                     /translation="DVVTGTFMGNRTNAKEKQMLGMFVSTVPVR"
     CDS_motif       complement(7499..7564)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0003"
                     /evalue="1.40E-07"
                     /label="C3_starter_134-155"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="159"
                     /protein_start="137"
                     /score="24.4"
                     /tool="antismash"
                     /translation="VHHIISDGISMTILGNAITDIY"
     CDS_motif       complement(7778..7897)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0002"
                     /evalue="5.50E-03"
                     /label="C2_starter_024-063"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="66"
                     /protein_start="26"
                     /score="9.4"
                     /tool="antismash"
                     /translation="ISNLAGFGKLISEDGVQAHYVEKAIQEFVRRYESMRIRLR"
     CDS_motif       complement(7922..7960)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PGW53_RS12435_0001"
                     /evalue="6.00E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="PGW53_RS12435"
                     /protein_end="18"
                     /protein_start="5"
                     /score="9.6"
                     /tool="antismash"
                     /translation="YPLTNAQKRIWYT"
     misc_feature    complement(8356..8369)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.84"
                     /tool="antismash"
     gene            complement(8566..8928)
                     /locus_tag="PGW53_RS12440"
     CDS             complement(8566..8928)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003156585.1"
                     /locus_tag="PGW53_RS12440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_104843070.1"
                     /transl_table=11
                     /translation="MSRMDEKTFNCEKELTLAVIGGKWKMLIMWHLGKEGTKRFNELKA
                     LIPDITHKILVNQLRELEQDLIVHREVYPVVPPKVEYSLTAQGESLMPILDAMYKWGKE
                     YMELINIDKTAIKESF"
     misc_feature    complement(8900..8911)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.4"
                     /tool="antismash"
     misc_feature    9061..9081
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.5"
                     /tool="antismash"
     gene            9160..9795
                     /gene="hxlA"
                     /locus_tag="PGW53_RS12445"
     CDS             9160..9795
                     /EC_number="4.1.2.43"
                     /GO_function="GO:0043801 - hexulose-6-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019647 - formaldehyde assimilation via
                     ribulose monophosphate cycle [Evidence IEA]"
                     /codon_start=1
                     /gene="hxlA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007409353.1"
                     /locus_tag="PGW53_RS12445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WP_015239130.1"
                     /transl_table=11
                     /translation="MELQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVQ
                     EMKTAFPHLKVLADLKIMDAGGYEIMKAAEAGADIITVLGATDDSTIKGAVAEAKKQQK
                     KILVDMINVKNLETRAKEIDQLGVDYICVHTGYDLQAEGKNSFEELTAIKKAVKSAKTA
                     IAGGIKLDTLPEAIKQNPDLIIVGGGITGADNKADAAAKMKQLITQGS"
     gene            9792..10349
                     /gene="hxlB"
                     /locus_tag="PGW53_RS12450"
     CDS             9792..10349
                     /EC_number="5.3.1.27"
                     /GO_function="GO:0043800 - hexulose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /function="Predicted sugar phosphate isomerase involved in
                     capsule formation"
                     /gene="hxlB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007409354.1"
                     /locus_tag="PGW53_RS12450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-phospho-3-hexuloisomerase"
                     /protein_id="WP_014416874.1"
                     /transl_table=11
                     /translation="MKTTEYLHEILNEISRTAALIADSEADKLADLILSADQIFTSGAG
                     RSGFMAKAFAMRMMHIGLNAYIVGETLTPPLQEGGLVIIGSGSGETKSLLHTAEKAKNL
                     NGIITALTINPASSLGKLADLTITIPGSPKEETGGDRKTIQPMGSLFEQTLLLFYDAVI
                     LKIMEKKELNSADMFTKHANLE"
     gene            10680..11117
                     /locus_tag="PGW53_RS12455"
     CDS             10680..11117
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016936798.1"
                     /locus_tag="PGW53_RS12455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NucA/NucB deoxyribonuclease domain-containing
                     protein"
                     /protein_id="WP_003156588.1"
                     /transl_table=11
                     /translation="MKTLKALLLVLIIIAGAVAALIKGDLFSDNEQTVQKSDYDKVILF
                     PSDRYPETAKHIKDAIKEGHSSICTIDRDGVHKRREQSLKHVPVKTGYDRDEWPMAVCK
                     QGGNNASVEYISPADNRGAGSWVGHQLTNDPDGTRVLFKIK"
     gene            11138..11536
                     /locus_tag="PGW53_RS12460"
     CDS             11138..11536
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388224.1"
                     /locus_tag="PGW53_RS12460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="competence protein ComJ"
                     /protein_id="WP_017419379.1"
                     /transl_table=11
                     /translation="MIKSWKPQELAISYHQFTLFQKDSEPPVIDWTDEAIEKGYAEADG
                     AVSFEARRNTRAFIVLRLNTSEPVPSYEKKATVPFEAVKDGIEIESVMSKRLSFNIPKG
                     RYSLTCYSVPAEISDLHADTYIIDAAAM"
     gene            complement(11577..13013)
                     /locus_tag="PGW53_RS12465"
     CDS             complement(11577..13013)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /function="Beta-glucosidase/6-phospho-beta-
                     glucosidase/beta-galactosidase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388223.1"
                     /locus_tag="PGW53_RS12465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 1 glycosylhydrolase"
                     /protein_id="WP_014416872.1"
                     /transl_table=11
                     /translation="MIHKKQGLFPDTFLWGSASAAYQVEGAWNKDGKGPSVWDLFTKIP
                     GKTFKGSNGDTAVGHYERYKEDIALMAEMGLKAYRFSVSWPRIFPNGRGEINESGIAFY
                     EDLIDELISNDIEPVLTLYHWDLPQALMDEYGGFESRKIIDDFNDYCIALYKRFAGKVK
                     YWVTLNEQNYNFHNGFITAAHPPGVKDRKRFYAANHIAFLANAKAIESFRQYVPDGLIG
                     PSFAYSPAYPLTSHPEDITAFENAEEFMNHWWLDMYCRGTYPQIPFNYLKEKGWAPAIE
                     AGDMELLAKGKPDFIGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQDTGIPGLFKTK
                     KNPNLVTSNWDWTIDPIGLRIGLRRITSRYELPVFITENGLGEFDKIEEDGSIQDDYRI
                     DYLRSHLEQCREAISDGVHLIGYCSWSFTDLLSWLNGYQKRYGFVYINRDEEDEKDLKR
                     IRKKSFYWYQNVIETNGKSL"
     gene            complement(13117..13440)
                     /locus_tag="PGW53_RS12470"
     CDS             complement(13117..13440)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016936802.1"
                     /locus_tag="PGW53_RS12470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YckD family protein"
                     /protein_id="WP_007409357.1"
                     /transl_table=11
                     /translation="MKKAALSLAAFFITAMVFTMPAHAAGTKMPSTMSLTEQQKKEIES
                     LEKEVLEKRKHVISKYVEYGVLPKEKAEHIKQHMDRRFNMMKQNGFVPKPPPHKLEKRH
                     HHS"
     misc_feature    13488..13501
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.4"
                     /tool="antismash"
     gene            complement(13512..13946)
                     /locus_tag="PGW53_RS12475"
     CDS             complement(13512..13946)
                     /codon_start=1
                     /function="Predicted membrane protein/domain"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014416871.1"
                     /locus_tag="PGW53_RS12475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RDD family protein"
                     /protein_id="WP_014416871.1"
                     /transl_table=11
                     /translation="MNIYRPAGFWIRLGAVVLDYLITSVPLAIIFMLATGKDPNESAMI
                     SIILTLYGILLPVYWNGYVIGKKICGIRIVKKDGTQVGFLTMILRVLVGGLIYGVTFGI
                     GVIVSAFMVGMREDRRSIHDFVAGTYVTYALPDESIEKSE"
     gene            complement(13961..15097)
                     /locus_tag="PGW53_RS12480"
     CDS             complement(13961..15097)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0004024 - alcohol dehydrogenase activity,
                     zinc-dependent [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012116766.1"
                     /locus_tag="PGW53_RS12480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-dependent alcohol dehydrogenase"
                     /protein_id="WP_270354391.1"
                     /sec_met_domain="ADH_N (E-value: 1.6e-32, bitscore: 105.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-13, bitscore:
                     43.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALTYQGKEHMEVKEVPAPAIQDERDVIVRITATGICGSDLHLY
                     KNGIPADPGYIVGHEPMGIVEETGSQVKKLKKGDRVVIPFNIGCGECHYCKHQMESQCD
                     ESNPNPHTDAGGLFGFSEFNGNYPGGQAEYLRVPYADFSSFLVPADSELEDEQVMLLSD
                     VMPTAFWSVQHSGVKKGDTVVILGSGPIGLMAQKFAWKKGAKRVIAVDQVPHRLEHARR
                     INGAETFNFSEHDEIGKLLHEQTSGGADVVIDCVGMDGTPLSKEKTEQKPNQFGTISPI
                     LTASEAVKKFGTVQLTGAYISEADGFPLGDFFTRNVSLKMGQAPVIHLMPMLYQMIEQN
                     EIDPTDIITHKMSLAEAPAAYDIFDKKEDGNIKVILKP"
     gene            complement(15162..16364)
                     /locus_tag="PGW53_RS12485"
     CDS             complement(15162..16364)
                     /codon_start=1
                     /function="putative GTPases (G3E family)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1178: cobalamin synthesis protein/P47K family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003156595.1"
                     /locus_tag="PGW53_RS12485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP-binding protein"
                     /protein_id="WP_014416870.1"
                     /transl_table=11
                     /translation="MKKIPVTVLSGYLGAGKTTVLNHILQNRNGLKIAVIVNDMSEVNI
                     DAGLVKQGGGLSRTDEKLVELSNGCICCTLREDLLVEVEKLAKDGRFDYIVIESTGISE
                     PIPVAQTFSYIDEEMGIDLTTFCRLDTMVTVVDANRFWHDFQSGDSLLDRKEAAGEEDE
                     RVIADLLIDQIEFCDVLILNKCDMVGEKELEQLETVLRALQPRARLIRSVRGEVPAEYI
                     LNTGLFEFEEASSSAGWIKELTAGHEAHTPETEEYGITSFVYSRRLPFHTARFDSWLHQ
                     SIPDNIVRAKGIAWCATRNSLALLMSQAGPAVSIEPVSYWVAAMPKLEQEQIKQQEPEI
                     LEDWDDQFGDRHTNLVFIGTDLDEAAITKELDQCLLTPSEFDSDWSQLEDPFQWDIQRA
                     E"
     gene            <16479..16637
                     /locus_tag="PGW53_RS12490"
                     /pseudo=""
     CDS             <16479..16637
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003224851.1"
                     /locus_tag="PGW53_RS12490"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="molybdopterin dinucleotide binding
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="SV"
     gene            16757..19174
                     /gene="nasD"
                     /locus_tag="PGW53_RS12495"
     CDS             16757..19174
                     /codon_start=1
                     /gene="nasD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_BFD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388212.1"
                     /locus_tag="PGW53_RS12495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADPH-nitrite reductase"
                     /protein_id="WP_224443498.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-60, bitscore:
                     198.8, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 2.5e-15, bitscore:
                     50.1, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKKQLVLVGNGMAGVRAIEEILRVSKDEFEITIFGAEPHPNYNR
                     ILLSKVLQGDTDIQDITLNDWNWYKENNIQLYTGETVIKVDTENKTLITDADRIQPYDE
                     LILATGSVPFILPIPGADKQGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEAARG
                     LLNLGMDVSVIHLAPFLMERQLDAAAGRLLQNELEKQGMTFFLEKQTEEILGTDRVEGI
                     RFKDGTSIKADLVVMAVGIRPNTQLGTESGIPVNRGIIVNDYMQTDIPHIYAVGECAEH
                     RGIAYGLVAPLYEQAKVLAKHICGIETKPYEGSVLSTQLKVSGVEVFSAGDFNESEDKK
                     AIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGSRLFSMIQKEADISETSKISILQPL
                     DQEAGASMTAAMSDDEIICGCNGVSKGAIIQAIQEKGCTSTDEIKACTGASRSCGGCKP
                     LVEDILQYTLGSEFDASAQKEAICGCTSLSRDEVVEEIRAKGLSHTREIMNVLGWKTPE
                     GCSKCRPALNYYLGMINPATYEDDRTSRFVNERMHANIQKDGTYSVVPRMYGGVTNSQD
                     LRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWAELDMPSGYAYGKTLRTVKTC
                     VGEQFCRFGTQDSMALGIALEKTFEGLNTPHKVKMAVSACPRNCAESGIKDLGVVGIDG
                     GWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANYLERTSAWLERVGL
                     SHVQSVLNDPEKRQELNDRMNETLSVHKDPWQYFLKDKKASKDLFENVVTTS"
     gene            19195..19515
                     /gene="nirD"
                     /locus_tag="PGW53_RS12500"
     CDS             19195..19515
                     /GO_function="GO:0008942 - nitrite reductase [NAD(P)H]
                     activity [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nirD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388211.1"
                     /locus_tag="PGW53_RS12500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrite reductase small subunit NirD"
                     /protein_id="WP_007409365.1"
                     /transl_table=11
                     /translation="MVNKDMTKVCIGKVNELPEELGKTVYIEDKELAVFKLSDGSVRAV
                     ENRCPHKGGVLAEGIVSGEYVFCPMHDWKISLEDGKVQEPDHGCVKTYETLIEGENVYL
                     LY"
     gene            19582..21021
                     /gene="cobA"
                     /locus_tag="PGW53_RS12505"
     CDS             19582..21021
                     /EC_number="2.1.1.107"
                     /GO_function="GO:0004851 - uroporphyrin-III
                     C-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019354 - siroheme biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015416774.1"
                     /locus_tag="PGW53_RS12505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="uroporphyrinogen-III C-methyltransferase"
                     /protein_id="WP_065180939.1"
                     /sec_met_domain="TP_methylase (E-value: 1e-47, bitscore:
                     156.2, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNGIVYFVGAGPGDPGLITVKGKQALEKADIILYDRLANPKFLE
                     YASPDCRFIYCGKLPDRHFMKQSEINALLIEKAAEGCTVVRLKGGDPSVFGRVGEEAEA
                     LHQHGIRYEMVPGITSGIAAPLYAGVPVTHRDFASSFAMITAHDTSLQGRPNLDWEGLA
                     RSVQTLVFYMGVKNLSFICRQLTEYGKSPSVPVLVIQWGTWGRQRSVKGTLQDIHEKVQ
                     NQNITNPAIIVIGDIVNFQTHSWFESKPFIGRHIMVVTHGDEEHTLTDKLREYGADVIE
                     WPKRIVKKMPANENILKQISTFEQLFFTSRLAVCEFFDTLAFKQIDIRRVTASLNAATE
                     AAKTELTKRGFLLSECQIDSPHSLIVGSRQAAENLSDSKSCPLYITHEHIADERFTSMI
                     ERTISESPLQMIICTGKESAQHLISAGKQIGISPDPSANRPPVICMGEDVPAGCGFTAV
                     KNQEQLFAFIRNEMKDMLVHS"
     gene            complement(21076..22086)
                     /locus_tag="PGW53_RS12510"
     CDS             complement(21076..22086)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388209.1"
                     /locus_tag="PGW53_RS12510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_017419373.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.4e-29, bitscore:
                     95.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAENHEVYDVTIIGGGPIGLFAAFYCGMRELKTKVIEFLPRLGGK
                     VSMFFPEKIIRDIGGIPGIAGEQLIKQLKEQAATFEPDIVLNQRVTGFERLEDGTIVLE
                     SSEGEKHYTRTVILAVGMGTLEVNELDSADASRYSGKNLHYKVEKLDAFRDKHVVISGG
                     GDTAVDWANELEPIAASVTVLHRREEFGGLESSVAKMKRSSVRVLAPYRLKLLNGTGER
                     IESVTVCQTESGLSEVIKLDELIINHGFKIDLGPMKDWGLEIEEGRIKADRHMRTNLPG
                     VFVAGDAAHYESKLRLIAGGFTEGPTAVNSAKAYLDPQADQMAMYSTHHKKLVTQ"
     misc_feature    complement(22106..22124)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.23"
                     /tool="antismash"
     misc_feature    22127..22142
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.55"
                     /tool="antismash"
     misc_feature    complement(22127..22145)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 25.74"
                     /tool="antismash"
     misc_feature    complement(22130..22145)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.89"
                     /tool="antismash"
     misc_feature    complement(22222..22236)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.06"
                     /tool="antismash"
     gene            complement(22284..23519)
                     /locus_tag="PGW53_RS12515"
     CDS             complement(22284..23519)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388205.2"
                     /locus_tag="PGW53_RS12515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_003156600.1"
                     /transl_table=11
                     /translation="MEELLERVFSFTDIDKLIDFISYELQKPVILESADFFLLAYNSYY
                     INHFDSANQQTIFSKKCPVQIFERFLKDGVIEKLKTVPEPFRVEKIDSIGLNQRVVVSA
                     KHKGEVMGYIWIQELDRNLTDEELDFLYETSFHVGKIIYKTNRLKQEKEERAEDLVKRA
                     IFQQFSSEKEFRREAEKMNAVLPSVFSVVVLHAANGDGEAVEDVKENIKSYLNLRDKVS
                     HVLTIDSNIVIVVASFSQKSSGTSAASEFIHKLLTHFHFQKIPTPIYIGIGNEYSSILK
                     LGKSYIEALEVIKAAEITGNQENIPYEYSKLGIYRYLESIEEKNASLEYVNDDLALLKA
                     KDRESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQILDMTSINLNDFRTRC
                     QLYLDIMLMKKR"
     gene            complement(23677..25131)
                     /gene="putP"
                     /locus_tag="PGW53_RS12520"
     CDS             complement(23677..25131)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005298 - proline:sodium symporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015824 - proline transport [Evidence IEA]"
                     /codon_start=1
                     /gene="putP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015239118.1"
                     /locus_tag="PGW53_RS12520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sodium/proline symporter PutP"
                     /protein_id="WP_017419372.1"
                     /transl_table=11
                     /translation="MIISICIYMAGMLFIGYFAYRRTSNLTDYMLGGRSLGPAVTALSA
                     GAADMSGWLLMGLPGAMFSTGLSGAWIVIGLVLGAWANWLFVAPRLRTYTEKAGNSITI
                     PGFLENRFGDHTKLLRLFSGLVILVFFTFYVSSGMVSGGVLFNSILGLNYHTGLWVVTG
                     VVVAYTLFGGFLAVSWTDFVQGIIMFAALILVPIVTIFHTGGPGETVADIRSVNPELFN
                     MFKGTTVLGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSALGALF
                     TGLAGIAYYHQRGLKLDDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTS
                     SSLVEDLYKSMFRRSASDKELVFLGRMAVLAVSIVALVLAWEKNNTILGLVSYAWAGFG
                     ASFGPVVLLSLFWKRMTKWGALAGMIAGAITVIIWANAGLSDFLYEIIPGFAVSLAAVF
                     VVSLLTQAPSKDVTDQFHDYRDTLSQ"
     gene            complement(25223..26770)
                     /gene="pruA"
                     /locus_tag="PGW53_RS12525"
     CDS             complement(25223..26770)
                     /EC_number="1.2.1.88"
                     /GO_function="GO:0003842 - 1-pyrroline-5-carboxylate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006562 - proline catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pruA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388203.2"
                     /locus_tag="PGW53_RS12525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="L-glutamate gamma-semialdehyde dehydrogenase"
                     /protein_id="WP_071181519.1"
                     /sec_met_domain="Aldedh (E-value: 1e-155, bitscore: 512.1,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPYKHEPFTNFQDQSNVEEFKKALAKVNEYLGKDYPLVINGEK
                     VETEAKIVSINPADKEEVVGKVSKASQEHAEQAIEAAAKAFEEWRYTSPEERAAVLFRA
                     AAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMVELAKGKPVNSRDGE
                     KNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFVEVLE
                     ESGLPKGVVNFVPGSGAEVGDYLVDHPKTSIITFTGSREVGTRIFERAAKVQPGQQHLK
                     RVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYDQVLERV
                     IEITESKVTASPDSADVYMGPVIDQGSYDKIMSYIEIGKEEGRLVSGGTGDDSKGYFIK
                     PTIFADLDPKARLMQEEIFGPVVAFSKVSNFDEALEVANNTEYGLTGAVITNNRKHIER
                     AKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKTISEMF"
     gene            complement(26788..27699)
                     /locus_tag="PGW53_RS12530"
     CDS             complement(26788..27699)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388202.1"
                     /locus_tag="PGW53_RS12530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proline dehydrogenase"
                     /protein_id="WP_088037528.1"
                     /transl_table=11
                     /translation="MITRDFFLFLSKSSFLNKMARSWGSRVAAGKIIGGMDFRSSIPTI
                     RHLNSQGLSVTVDHLGEFVNSGDVAKERTEECMQTIALIADEQLNSQVSLKMTSLGLDI
                     DLDLVYENMTKILQTAEKHKVMVTIDMEDETRCQKTLDIFKDFRSRYEYVSTVVQAYLY
                     RTEKDLDDLSPLNPFLRLVKGAYKESEKVAYPEKSDVDENYKRLIRKQLLKGHYTAVAT
                     HDDKMIEFTKQLAEEHGIPNDRFEFQMLYGMRSQTQLSLVEEGYRMRVYLPYGDDWYGY
                     FMRRLAERPSNIAFAFKGMTKK"
     misc_feature    complement(27774..27788)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.3"
                     /tool="antismash"
     misc_feature    27808..27824
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.17"
                     /tool="antismash"
ORIGIN
        1 tgtagctgtc cggcacgtcc agcgcttcct gtgtgagaag aagcttggcg ccgctgtcct
       61 gcagaatgta gatgatccgc tcttccgggt agtcggggtc aatcggcaca aatgccgcgc
      121 ccgctttcag gacgccgagt acgcccgcgg ccatttccaa ggacggtttc gtcaggatgc
      181 cgacacgctc gtcagccgtg acgccgcagt ccatgagaat gcgcgcgatc cggttcgccc
      241 ttgcgttcag ctcgccgtac gtccatttcg cgccgttata tgccgcggcc ggccggttcg
      301 cgtagcgggc ggccgtttct tcaaagagac ggtgaaccgt tttgtcccgc ggcacagaaa
      361 ttgtttttcc tttccattcg tcaaggaggg cttgtttttc tgtttcattc accaatgaaa
      421 gctcagaaag cttcgcggcc ggattttccg ctgcggcttc taacagttga agccagtaat
      481 gcttccatgt ctctgccgtt tccggtttaa acagcgcagt gttatattca agcacaaacg
      541 ttaagccttc gtctgtgtcc tcagccgtca ttgtcaggtc aaacttggct gtttttctgt
      601 caaacggatg gtgcttcagc tcaattcctt ccatgaccag attttccgca tttgcatttt
      661 gcattgagaa taccgcatca aacagcggat ttctgctcgt atcacgctgc acctcaacct
      721 tttgcagaag gtcttcaagc ggataatcct gcgcgtcaaa tgcatgtaaa gcggtttgtt
      781 tcacttcttt aagatagtcc gtgaacgttt tgtccgcttc cggatacgta cgaagcgcga
      841 gtgtattcac aaaaacaccg atgacgtttg tgagatccgc atgtgaccgt cccgcaaccg
      901 gcgaaccgac aatgatgtca tgctgtccgc tcagttttga gagaaaggcg ctgtatgacg
      961 ccagcagcac catgtacatg gtagaatccg tttgtttcgc aagactgcga agagccgacg
     1021 tctgttcctt agtcagagaa aagaccagct tgtctccttc aaaggtttgc acggccggac
     1081 ggctgtaatc agccggcagc gtcaataccg gaagctcgcc gtcaagctcc cgaagccaat
     1141 gctcctcctg cttgcggtac tgctctgatt gaataaattt ctgctgccat accgcatagt
     1201 ctttataatg aatccgcagc ggctcaagcg tttcgccgcc atataagcgg gacagttcat
     1261 ctatcagcac gccgactgaa gcgccgtccg aaatgatatg gtgcatatca aacagcagca
     1321 ggtggtcatg ttcagccagc ttgaccagtc ccgttctgac gagaggaagc tgatccaggc
     1381 ggaacggccg gataaagctc tgaataatcc gttcagcatc ttcttcagag gcttcataat
     1441 attccatgtc gatatcagct tccgcccata tgcgctgaac cgtttctcca tcctttatgt
     1501 caaatgtcgt tctgaaggct tcatggcgtt ctgtcagctg tttcatgacg gatttcagct
     1561 tttctgcatc aagctttcct tttaagcgga gcacagacgg catgttatag cttgtttcag
     1621 cgccttccag ctgctgaagc acgaacatcc gcttctgcgg tgaagaaacc ggatacgttt
     1681 cccgctcggc cgccggtgtg atgctctcag ccgccttccg ctcagcccct tcaatcagct
     1741 gcgccagccc cgcagccgtc ggagaagtga acagatcctt taaggtaagc tgcacgccga
     1801 atgtcttctg gatgagggca agcagtttca tccccgctaa cgaatggcct ccgatctcaa
     1861 agaactgatc atggacgccg acccgctcca tttgcagcac ctcagcccaa atatccgcca
     1921 gtttttgttc tgtttcgttg cgcggcgccg tataagacac ggcattcgct gcggtcacat
     1981 ccggcatcgg cagcgcccgc ctgtcgattt ttccgttccc tgtaagaggc agttcatcca
     2041 attgaataaa gacggacgga atcatataag ccggaagatc cttcgccgta tgctccctaa
     2101 gctcccggga agagatttcc ctgaggccga caacatacgc gcaaagaagt ttgtcacccg
     2161 cgccctgatc cacagcgagc acaatgcatt cctgaatctg gtcatggctt tggagctgat
     2221 gctcaatttc gccaagctca atccgctgac cgcggatttt cacctgatga tcgatacgtc
     2281 cgataaactc gatatcgcca ttcggaagcc atctggccaa gtcgcccgtt ttatacatcc
     2341 gttcaccttc cttaaacgga tgctctacaa atttttcttc cgtcagttca ggacggttgt
     2401 agtacccttc tacgagacct tccccgctga cgcacagctc tcccgcgata cccgccggct
     2461 gaatgcgtcc ggctgagttc ataataaaga cttccgtatt gctgaccggt ttcccgatcg
     2521 gaacggagag cgtatcctct tcaatgacat ccaccggatg gtatgtcgca aacaccgtgc
     2581 tttccgacgg gccgtacata tgaagcagtc ttccttttcc gactgccgcc agcgcttttt
     2641 tgacatgttc tacagacgct ctttcgcccc cgaacatgat tttccgaagc gtcgtcagac
     2701 aggacggctc catatcaaca agcaggtgga acagggccgt cgtaatcatc agaatgctga
     2761 cgttctcccg tttgatcaca cgggacaggc gtgacatatc cagcaccgta tctttcggga
     2821 cgatcacaag ctttgcaccg tttaacagcg aaccgaacat atcaaacata aaagcgtcaa
     2881 agacgtagtt tgacagaccg agcactgtgt cctcttcaga aacagtcaaa tagttcgtgt
     2941 tttttaccgt ccgcaaaatg ttggcatgtg tgacgatgtt tcctttcggc gttcccgtcg
     3001 tgcctgatgt ataagtgaga ttggcaatcg ttttggaatc aaacggcaat gctggattgc
     3061 gagagtcctt ttcatagctc gcctcatcat cagcaagcac aatgacgcct tgaaaaccgg
     3121 ccttttccgc aagcggcttg aggctttgct gagtcatgag cacattcgcc ccgctgtcgc
     3181 ggaagaaatg ctgaatccgc tgaaccggat gctcaggatc aatcggcaca taggcggacc
     3241 ccgcttttaa cacagccata atggaaacaa tcatatccat tgaccgttca cacagaacag
     3301 ccgcggtttt tccgccgcct ccgaccgaaa gaatatgccg cgcaagcctg ttggcgcgtt
     3361 cattcagatg ctgatacgac agggtttccc cttcgaactg aagagccgtc cggtcagggt
     3421 tctttcgggc ttgttcttca aagatctgca cgatcgtttg ctctttcggg tataccgtgc
     3481 gttccgggtt gaattgctgt aattgagtca aagcctcccg ttcagaaagc agatcatatt
     3541 cgctgatttt cgcatccggc tgagctgccg cgctctccag cagacggaca tagtgcgcaa
     3601 gcatgcgatc cgcagttgag cgcttaaaca gcttcgtgca ataatccaaa tcaagcgcaa
     3661 tgccttccgc tgtttcccgg gcctgcatgg tcaggtcgaa tttggcgatg ttgaagtttg
     3721 tttcatgaag agacagcgtc agattaccga tctccggaat tccgtccgaa gcattttgca
     3781 gactgaacat cgtgtcaaat atcggatgcc tgctcatgtc ccggggcacg ttcagctcct
     3841 cggtcagcca ctcaaacgga taatcctggt gggaaaacgc atccagcacc tgcttgcgca
     3901 catgacctaa caagccggca aatgtctgac cctgcttcac ggagcttcgc agcgcaagcg
     3961 tgttgacaaa catcccgata agcccctcgg tatcagagtg gtttcttccc gctgatggtg
     4021 ttcccacgat gatgtcttcc tgtcctgaat acttagaaag cagcgtatag tatgccgata
     4081 acagcaccat gtaaagggtg gctccgtttt tctcggcaag cttctgcagc cgttcccgca
     4141 gcattttcgg cagcttgacg gacacgcggt caccttcaaa gctttgcacc tgcggccgcg
     4201 gataatcagg gagcagctga agcaccggca gttccccgct gaagacttct ttccagtacg
     4261 cccgctcctt cttgtagcct tctttcgccc gttccgcctg ccatacggca taatctttat
     4321 attgaatgcg caattcaggc agctgatttc ccccgtagat gtcagccagt tccttcagca
     4381 tgatggaaat agacaccccg tcagaaatca ggtgatgcat atcaaacagc agcagatggc
     4441 gattgtgacc gagcgtttgc aggccgattc tgaacagcgg cgcctcagat aaatcaaaac
     4501 ggcgcacaaa gtccttcatg acctgttcat tcgttcttcc gcgcgcttcg atcatttcaa
     4561 tatgaaacgg aacatgctcg ccaatcactt gtctcggcgt gccgtcctct gattgaaacg
     4621 atgttctgag cgcttcatgc ctgctgatta aggcagaaaa tgcacgctca agcttttcac
     4681 ggtctaaagc gccctcaatc atggccgcag ccggcatgtt atatccgact cccgcgtctt
     4741 caaattggct tgcgatataa gtccgctgct gagcgagcga aagcggatag ctcgcctgct
     4801 tctcagccgg ctcaattgca ctgaatgccg gtccttcgtt tcggttttcc gcataatcgg
     4861 caagcgccgc aatcgtcgga tgctcaaaca agtattgcag cggaatttca acgcccattt
     4921 gcttatgaat tttcgtcaga agcgtcattg cctttaatga atgaccgcct gactcgaaga
     4981 aatgatcata aatgcccgcc ttgtccattc cgaggacttc ctgccagatg acggtgagca
     5041 tttcctccgt ttcatttctc ggcgcggcat attcagatga gctgacagcc tgcacatcaa
     5101 gcgcaaacag ctttttgcgg tccgccttcc cgctcggcgt gagcggaatt tcgtccgttt
     5161 ttgtaaagta agcgggcacc atgtaatcag gaaggtgctt ggacacatac tccctgtact
     5221 cggcagggtg aaactcggtt cctttttcct gaacgatata tgcgcagaca tctaagctgc
     5281 cctgctgatc cggccgtgcc agcacgacgg cctgcgccgc gcccggagct tttctgagca
     5341 ccgtttcaat ttctcccagc tcaatgcggt agccgcggac tttcacctga tcatcttcac
     5401 ggccgatata ttcgatcgtc ccatccggca gccagcgcgc catatcaccc gtgcggtaca
     5461 tgcggccgct tccgttaaac gggtcctgca aaaacttctc tgcggtcaaa tccggaagat
     5521 ttaaatagcc gcggcctaca ccgtcacccg cgatatacag ctcaccggcc gtgccgtcgg
     5581 gctgaagccg ctggtgctta tccaatatat acagacgggc gttgccgagc ggttttccga
     5641 tcggaacgta cgccgcctgt tgattcattc cgttatccgc tgacacctga tgcacggacg
     5701 catctacaca cgtttctgtc ggcccgtaga cattcgtcag acgcggcgtc ctgcccgatt
     5761 gatgaaagag cgtcatcagc tgttcagcaa cagccgcgga caggccctct cccccaatga
     5821 gcatgtggcg caattcaatt ccgctgacat ctcccgccgc aaccatcatc tgcagatgcg
     5881 caggcgttcc gtcagtggct tcaatccggt tttgacgata atagtccagc agtgccgagc
     5941 cattcgtcac agtcgttttc ggcacgatat aaagcgtctg tcccaaaaga agcgaagcga
     6001 aaatctgttt gacggacgca tcaaaatgaa acggagccaa aagcgccatt cttaacgtct
     6061 gctcaccgca ttgataaatc tcctgctgca gtgattgcac cagatgatga acttgccggt
     6121 gctcaatcat cacgcctttc ggccgccccg ttgtacctga cgtgtagatg atgtaagcca
     6181 gccggtctga ttgaatgccg acaccgtccg cagccgtctc atactgaaca gcctcgtcaa
     6241 aatcaatccg ttcggcatcc gctgcaggcg cctgtattcc ggcctccgtc agaacagcct
     6301 tcgctccgct gtcctccaaa atgtactgaa tccgatccgc cggaaagtca ggatctatcg
     6361 gcacataggc gccgcccgct ttcaaaattc ccaatattgc cgcaatgaca cactcagaac
     6421 ggccaagcag caccgcgaca ggagaatcgg ctgatatccc ggcttgaaga agacgtccgg
     6481 caatacgtcc tgactgttca tgcaatgtgc gataggacaa tgttcggcct tcatacacaa
     6541 ccgcgggttt gtcagacagt gacttcactt tctcttcaaa cagccccgga atcgtcatct
     6601 ccttgcggta attcaccgga ttgccggagg cccgtttcag cagccgctct ttctcggatt
     6661 cagaaagaag agtaagttca tcaattatgc gatcaggaga tgaaatcgca tcttcaatca
     6721 gcgtgatcaa acgttcagaa acagattcaa tctcttcccc cttgaaaatg tcgctgcgat
     6781 agtcaaaatc aatcgtcaat ttcccggtgt cccatcgttc cttcacatga attgaaatat
     6841 catttgtacc gcttccgctg aaaatagggt ctgtcaggaa ggacagattc tcttttttct
     6901 gccactgcat cacctggtac tccagagcca ccgtaaacaa tctgctcagc gaacttttcg
     6961 aagcgcgcaa atcattgaca agcaggttat acggatactt ttggtggcgg agaattttca
     7021 tcaaatcctt catccggcct ttaacgaatt ccaagaacga ctgtcctccg tcaacgcttg
     7081 tccgcacagg caccgtagat acgaacatcc cgagcatctg cttttctttc gcattcgtcc
     7141 ggtttcccat aaacgtaccc gtgacaacgt catcacgacc ggtcactttg tagagataag
     7201 tgatcagagc tgactggaac agagacagta cgctgacttt atgctcctcg cagaatgaat
     7261 gaatgcggcc atataagtcg tgaggaattt cttgagaaaa ccgtttcgca ttaagacccg
     7321 catctgcctg gctccgtttc agggacacaa gctccggcac ggtctcaaac tgcccgttcc
     7381 aaaaatcccg atccttttta aaccgcttcg actgcacata ttcctgctct gtcagcacat
     7441 gctcaataaa agaaggaatc tccgtctgtt cctcacttgt cccgcctgaa agctccaaat
     7501 aaatatcagt aatcgcattg cccagaatcg tcatggaaat cccgtctgaa ataatgtgat
     7561 gcacattagc gtaaaaccag acctcatttt cactgatcgt gtgcacggaa aaacggaata
     7621 aatcctgatc atataacgcc agaggcttgc cggcttcttc acgcccccat ttggacagct
     7681 cgtccgcaga gcagccggct tgcctgatat ccgtgtgccc gatagagagc ggacggtatt
     7741 cgctcacata ttgaacgggc tccccctcat catcaagccg cagacggatt ctcatcgact
     7801 cataccgccg gacgaattcc tgtatcgctt tctcaacgta atgagcctgt acgccgtctt
     7861 cagaaatgag tttcccgaaa ccggctagat ttgaaatgct tgtgttcgga tagaattttt
     7921 ctgtatacca gatacgtttt tgagcatttg ttaaaggata aaaagttatt tccatatgtg
     7981 tgcgcctccc ctttttaaga taaagttgtc aattctccct tagaaacagc ctccctctat
     8041 gtccctaact cattctcaag ccaaaagaac cacttacctc caaaaacgat cccgattcaa
     8101 tcaccgccga aatccgtcat ccgttcaccc gcgcagtccg aaatgcggca tcaaatttat
     8161 gagaaatcaa gacaaaaagc cattgattgt aagcacgaaa ggtttaccta tttctgcatg
     8221 tatttctata tatctactta cgttcacttt atatgaaaat attgttttta tcaccgaaaa
     8281 atgggtgaaa agtttcatgc ggcacaccga aaaaaatccg acgaatccag agggtatttt
     8341 gcggcatccc gcaatttatt ttcaaaaata ttatttacgt aaaattaaaa atctttaaac
     8401 tataatgaaa atctgtcgaa tatccagtta tggcagaatg aaaaaaattt acgtacgtaa
     8461 gctgacccgg aaaaaacagc gcaagaaccg aaacaggaga tttaatcgtt cgcaatatga
     8521 tttcattaaa ccgcaaaaaa agcactctat tttacataga gcgcttcaaa aagattcctt
     8581 tattgcagtt ttatcaatgt tgattaattc catatattct tttccccact tatacatggc
     8641 gtccagaatc ggcataaggc tttctccttg cgccgttaaa gaatactcca ctttcggagg
     8701 gacgacaggg taaacttccc tgtgaacgat cagatcctgc tccagctccc tgagctgatt
     8761 cacaagaatt ttgtgcgtaa tatccggaat taaagctttc agctcattaa accgcttcgt
     8821 cccttctttt cccaagtgcc acataatcag cattttccac ttcccgccta tcacggcaag
     8881 cgtcaattcc ttttcgcaat taaacgtttt ctcatccatt cggctcacgg acaattctcc
     8941 ttcctcttac tttttgtacg gtcattatct attcatacac gcttactttt tcacacaact
     9001 ttcgtcagtt tatactacca cgcagttttg ctgaaacaaa gcgcattgcc tgcggggaca
     9061 gtatcctcaa agtaactatt agacttcaaa gtgcgtactt ctcaacatgc ggggcactct
     9121 atagaatgga aatacatgaa aaagaggagt ggatataaag tggaattaca gctggcatta
     9181 gacttagtaa atatcccgga agcaattgaa cttgtgaaag aggtcgaacc atatatagat
     9241 gttgtagaaa tcggcactcc cgttgtcatt aatgaaggac tgaaagccgt gcaggaaatg
     9301 aaaacagcct ttcctcactt gaaagtgctt gccgatctta aaatcatgga tgcaggcggt
     9361 tacgagatta tgaaagcggc agaagcggga gccgacatca tcaccgtttt aggggcgaca
     9421 gacgactcaa cgatcaaagg ggcggttgcc gaagcaaaaa aacagcagaa aaaaatcctc
     9481 gtcgacatga ttaacgtaaa aaaccttgaa acacgggcaa aagaaattga ccaactcggt
     9541 gttgattata tttgtgttca cacaggttat gatcttcaag cagaaggaaa aaattcattc
     9601 gaggaactga cggcgattaa aaaagcggtc aagagcgcta aaaccgcaat tgccggaggc
     9661 attaaacttg atacgcttcc tgaagccatc aaacaaaacc cagatttaat cattgtcggc
     9721 ggaggcatta cgggagctga caataaagcg gatgctgctg ctaaaatgaa acagctgatc
     9781 acacaaggat catgaaaacg actgaatact tacatgaaat actaaatgaa atatcccgca
     9841 ccgcagcatt aatagccgac agtgaagctg acaagcttgc ggatctgatt ttatcggcag
     9901 atcaaatctt cacgtccgga gcgggccgtt ccggctttat ggctaaagcg ttcgccatga
     9961 ggatgatgca catcggcctg aacgcttaca tcgtcggtga gacgcttacc cctcccctcc
    10021 aagaaggcgg tctcgtcatc atcggctcag gctcaggcga aacaaaaagt ctgcttcata
    10081 cggctgaaaa agccaaaaac cttaacggca tcatcactgc attaacgatt aaccccgctt
    10141 caagtctcgg caaacttgcg gatcttacaa taacgattcc cggctctcct aaggaagaga
    10201 ccggcggaga cagaaagacg attcagccga tgggttcttt attcgaacaa actcttctgc
    10261 tgttctacga tgcggttatt ctaaaaatca tggagaaaaa agaattgaat tcagcagaca
    10321 tgtttacaaa gcatgcgaat ctggaatgat ttgctgacgg ccttcttatc agatggccgt
    10381 ctttttatcg tcctgtttcg cacgacactc gcagacgaag atacctcgcc ggtgagctta
    10441 tcgctataat aagtcaattg acgatacacc cgcaaccatt catttctgaa tagggaaacg
    10501 gcaaaaaaca ctttctgatc gaatttttaa tgaataaagt tgatttgtgc ggatggtttt
    10561 acagatattc agctgaattg cggctgagaa atatatttta acagctttac agccggccga
    10621 ttctgcttta ttcttggacc agcttaacag caatttataa ctggaggtga ttgatactct
    10681 tgaaaacatt aaaagcactg ctgcttgttc ttatcatcat tgccggagca gtcgcggccc
    10741 tgatcaaggg tgatcttttc tccgataacg agcagaccgt tcagaagagt gattacgaca
    10801 aagtaatcct atttccgtcc gatcgatatc cggaaacagc aaagcatatt aaggacgcga
    10861 taaaagaagg gcattccagc atatgcacca ttgacagaga cggagtacat aagcggcgtg
    10921 agcaatctct taaacatgtg cctgtcaaaa cgggttacga tagggatgaa tggccgatgg
    10981 cggtttgtaa acagggcgga aataacgcct ccgtagaata tatttctccg gcagacaacc
    11041 gcggagccgg ctcttgggtc ggacaccagc ttaccaatga tcccgacgga acgagagtat
    11101 tatttaaaat taagtaaaaa acaggaggaa cagcgcattg attaaatcat ggaaaccgca
    11161 agaactggcc atttcttatc atcaatttac actctttcaa aaagattcag aaccgcctgt
    11221 tatcgattgg accgatgaag ccattgaaaa aggatatgcg gaagctgacg gagctgtttc
    11281 atttgaagca aggagaaata cgagggcatt tatcgtcctc aggcttaaca caagtgaacc
    11341 ggtaccatcc tatgagaaaa aagcgactgt tccctttgag gctgtaaaag atggaattga
    11401 gattgaaagc gtgatgtcaa agcggctttc ttttaatatt ccgaaaggcc gatacagcct
    11461 tacctgttat tcagtgcctg ccgaaatatc cgatcttcat gcggatacgt atattattga
    11521 tgcagccgca atgtaaaaga aatccctgag agaatcatat ttctctcagg gaacttttat
    11581 aaacttttac cgtttgtttc aattacattc tgataccaat aaaaactctt tttcctgatc
    11641 cgtttcaaat ctttttcatc ttcttcatct cgattgatat agacaaaacc gtagcgtttt
    11701 tgatagccgt tcagccagct taacagatcc gtgaatgacc agctgcagta gccgatgaga
    11761 tgaactccat cactaatggc ctctctgcac tgttcaagat gggagcgtaa atagtcaatt
    11821 ctgtagtcat cctgaattga gccgtcttct tctattttat cgaattcccc cagcccgttt
    11881 tctgttataa aaaccggcag ctcatagcgg ctcgttatac gccgaaggcc gatgcgcaga
    11941 cctatcgggt caatcgtcca atcccaatta ctcgtcacga ggttaggatt ctttttcgtt
    12001 ttaaacagcc ccggtatacc ggtatcctgg tttgtccctt tctgaccagt cgtgttcatt
    12061 ttcccctccg atacaccatc aagaggattt ctttcgtacg taatcgtctg ataataatta
    12121 acaccgataa aatccggctt gcctttcgca agcaattcca tatccccggc ttcaatggcg
    12181 ggcgcccagc ccttttcctt taaataattg aaaggaattt gcggataagt cccccggcaa
    12241 tacatatcaa gccaccaatg gttcataaat tcctctgcgt tttcaaatgc agttatgtct
    12301 tcagggtgac ttgtaagcgg ataagccggt gaataagcga agctcgggcc gatcaaaccg
    12361 tcaggaacat attgtctgaa ggattcaatc gctttggcat tagctaaaaa tgcgatatga
    12421 ttcgctgcat aaaatcgttt tctgtccttt acgccgggcg gatgtgcagc tgttataaac
    12481 ccgttatgaa aattataatt ctgctcattt aacgtgaccc agtatttcac cttgccggca
    12541 aatcttttgt ataacgcaat gcagtaatca ttaaaatcat caataatttt tcttgattca
    12601 aagccgccgt attcatccat cagcgcctga ggcaagtccc aatgataaag agtcagcacc
    12661 ggctcaatat cgttagaaat caattcatcg atcaggtctt cgtaaaatgc gatccctgat
    12721 tcgttaattt cccctctgcc attcggaaaa attctcggcc agctgacaga aaatcggtaa
    12781 gctttcaaac ccatttctgc catcaaggcg atatcttctt tatagcgctc ataatggccg
    12841 actgctgtat cgccatttga gcctttaaac gttttacccg gtattttcgt gaataagtcc
    12901 catactgaag gtcctttacc gtctttattc caagctcctt caacctgata ggcagccgag
    12961 gctgaccccc atagaaatgt atcagggaac aggccctgtt ttttatgtat catgtgtttc
    13021 atcctcctga tgcatatgat attgatatca tacgttatga aacgcgtttc agagcaatcc
    13081 cgataaaaac aaaaaagcat ccggcttgcc ggatgcttaa gaatgatgat gccgcttttc
    13141 caatttatga ggcggaggct tcgggacaaa cccattttgt ttcatcatgt taaagcgcct
    13201 gtccatatgc tgtttaatat gttctgcttt ttctttcggc aggaccccgt actcaacata
    13261 tttggatatg acatgttttc gtttttcgag cacttctttt tcaagtgatt caatttcttt
    13321 tttctgctgt tccgtgagtg acattgttga aggcattttt gttccggcgg cgtgtgccgg
    13381 cattgtgaaa accattgctg taatgaaaaa cgcagctaaa gacaatgcag cttttttcat
    13441 gactctttcc tcctttaacg tttgttatat gttgctcccc catccatttt ttatgcaaaa
    13501 aaagagcgaa attattcgct cttttcaatc gattcgtccg gcagcgcgta tgtgacatac
    13561 gttcctgcta caaaatcgtg gattgaccgt ctgtcttctc tcattccgac catgaatgcg
    13621 ctcacgatca caccgattcc aaacgtcacg ccatatatca ggccgcccac aagcactctc
    13681 aaaatcatag tgagaaagcc tacctgagtt ccgtcttttt tgacgatgcg gataccgcag
    13741 atctttttgc cgataacata accgttccag tatacaggga gcaaaatacc ataaagagtc
    13801 aaaataatgc tgatcattgc gctctcattc ggatcttttc ctgttgccag cataaaaata
    13861 atcgccaaag gcactgaagt aattaaatag tcgagtacca cggctcccaa tctgatccaa
    13921 aatcccgccg gtctgtaaat attcatcgtg tttctcctcg ctatggcttc aaaatcactt
    13981 taatgttgcc atcttctttt ttgtcaaata tatcatatgc agcaggagct tccgcaagac
    14041 tcattttgtg tgtaatgata tccgtcggat caatttcatt ttgttcgatc atttgataca
    14101 gcatcggcat cagatgaata acgggtgcct ggcccatttt taaagaaacg ttgcgtgtga
    14161 aaaaatcgcc gagcggaaag ccgtccgctt cagaaatgta tgcgcccgtg agctgcacgg
    14221 ttccgaactt cttaacggct tctgatgctg taagaatcgg actgatcgtt ccgaactgat
    14281 tcggtttttg ctctgttttt tcttttgaaa gcggcgtgcc gtccattccg acacaatcaa
    14341 tcactacatc cgcgccccct gacgtttgtt catgcagcag tttcccgatc tcatcatgtt
    14401 ctgaaaaatt gaaggtctct gctccgttta tgcgtctcgc atgttcaagg cggtgcggga
    14461 cttgatcaac tgcgataacc cgtttagctc cttttttcca cgcgaatttt tgcgccatta
    14521 agccgatcgg gcctgatccc agaataacga ctgtatcccc ttttttcact ccgctgtgct
    14581 ggacgctcca aaaggcggtc ggcatgacat ctgacagaag catcacctgc tcatcttcaa
    14641 gctcactgtc tgccggaacc agaaaagaag agaaatcagc ataaggaaca cgtaaatatt
    14701 cagcctgccc gccgggataa ttaccgttaa actccgagaa accgaataag ccgccggcat
    14761 ctgtatgagg gtttggattt gattcatcac actggctttc catctggtgc ttgcaataat
    14821 gacattctcc gcagccgatg ttaaaaggaa tcacgacccg gtcgcctttt ttcagctttt
    14881 tgacttgact gcccgtttct tcaacgattc ccatcggctc atgcccgacg atataacccg
    14941 gatcggcggg tattccgttt ttatataaat gaaggtctga accgcatatc ccggttgcgg
    15001 tgattcgaac gatgacatct ctctcatctt gaatggcggg tgccgggact tctttcactt
    15061 ccatatgttc ttttccttgg tatgtcagtg ctttcacact tggtcagctc ctttttcatc
    15121 actccttccc ttttcacctg cttctaaact tggccggtat gttattcggc ccgctgaata
    15181 tcccattgaa aaggatcttc aagctgcgac caatcggaat cgaactcaga cggcgtgagc
    15241 aggcactgat ccaattcctt tgtaatggct gcttcatcta aatctgttcc gataaacacc
    15301 aggttcgtat gacggtctcc gaattggtcg tcccaatctt ccagaatctc cggttcctgc
    15361 tgtttgatct gctcctgctc aagtttcggc attgccgcca cccaataaga aacaggctca
    15421 atcgaaaccg ccggacccgc ctgagacatc agcagcgcaa ggctgttgcg ggttgcgcac
    15481 caagcaattc cttttgcgcg cacaatgttg tcagggattg attgatgcag ccagctgtca
    15541 aaacgagcgg tatgaaacgg cagacgccgc gagtacacaa acgaagtgat gccgtactct
    15601 tccgtttccg gagtgtgcgc ttcatgacct gccgtcagtt cctttatcca tcctgctgat
    15661 gaactcgctt cctcaaactc aaataaaccg gtattcaata tgtattcggc gggcacttct
    15721 ccgcggacgg accggatcag tctggcacgg ggctgtaatg cgcgaaggac cgtttccagc
    15781 tgttcaagct ctttttcgcc caccatgtcg catttattta aaatgagcac atcacaaaac
    15841 tcgatttggt caattaataa atcggcaatc acccgttcat cctcttctcc cgccgcttcc
    15901 ttccggtcaa gaaggctgtc accggactgg aaatcatgcc agaagcggtt tgcatccacc
    15961 acggtcacca ttgtgtccag cctgcagaat gttgtcagat caatgcccat ttcttcatct
    16021 atataagaaa atgtttgggc aacgggaatc ggttcgctga tccctgttga ttcaatcaca
    16081 atataatcaa atctgccgtc tttcgcgagt ttctcaactt cgactaatag atcctcacgc
    16141 agcgtgcagc agatacagcc gttggataat tctacgagtt tctcatccgt ccttgacaag
    16201 ccgcctccct gcttcaccaa tcccgcgtct atatttactt cgctcatgtc attgacgatg
    16261 acggcaattt ttaaaccgtt gcggttttgt agaatatgat tcaaaacggt cgtctttccg
    16321 gcaccaagat agccgctcaa tactgtaacc ggaatttttt tcatatcaat agccccctaa
    16381 caaaatagaa tgattacgat ttatatcccg caactccctt attatcacga tgtacatggt
    16441 tacaaatcgt aatcgttact atttattttg atatattctc cgtttaaaat caagtaaaag
    16501 tcagacatca tacattgttt gtccccatcc attggtctga cacgcaaaac gtcaacgatt
    16561 taattggtga agccttggac ccggactgta aaatgcccgg ttttaagatg tgcgcggtac
    16621 gaatcagccc tatataattt ttcataaaat ttttagattt tttagtattt tttgttacat
    16681 ttcataacat gcatcttaaa tatttgtttt tgctgtgcta cgctaaaaaa aacaaagata
    16741 aggagcggat catctgatgg gaaaaaaaca gctagtcctt gttggaaatg gaatggccgg
    16801 ggtaagagcg attgaagaaa tactgcgtgt ttcaaaagac gaatttgaga ttacaatatt
    16861 cggggccgaa cctcatccca actataaccg aatccttctg tcaaaagtgc tgcaaggcga
    16921 taccgacatt caagacatta cgttaaacga ttggaactgg tacaaagaaa acaacattca
    16981 gctgtatacc ggtgaaacag tcatcaaagt cgacacggaa aacaaaaccc tcatcaccga
    17041 tgcagacaga atccagcctt acgatgaact catcctggcg acaggctctg tcccttttat
    17101 ccttccgatt ccgggcgcag acaaacaagg cgtcacggca ttccgggaca taaaagatac
    17161 agacacgatg ctcgccgcgt caaaacaata taaaaaagca gccgtcatcg gcggaggact
    17221 gctgggtttg gaagccgcac gcggactgct gaatctcgga atggacgtgt ctgtcatcca
    17281 cctcgcccca ttcctgatgg agcgccagct tgacgcagcg gcgggacgcc tgctgcaaaa
    17341 cgaattagaa aaacaaggca tgaccttttt ccttgaaaag caaaccgaag aaattctcgg
    17401 tactgaccgt gtcgaaggga tacgcttcaa agacggcaca agcatcaaag ctgatctggt
    17461 cgtcatggcg gtcggcatcc gcccgaatac acagcttggc acagaaagcg gcattccggt
    17521 aaaccgcgga atcattgtca acgactatat gcagactgac attccgcaca tttacgcggt
    17581 cggtgaatgt gccgagcacc gcggaatcgc atacggtctt gtggcgccgc tctatgaaca
    17641 ggcgaaagtg ctcgcaaagc atatttgcgg cattgaaaca aaaccgtatg aaggctccgt
    17701 tctctccact caattaaagg tatcaggcgt cgaagtcttc tctgccggtg actttaacga
    17761 atcagaggac aaaaaagcga ttaaagtgtt cgatgagcag gacggcattt ataaaaaaat
    17821 cgtcctgagg ggcaatcaaa ttgtcggcgc tgttttgttc ggcgacagca gcgagggcag
    17881 ccgcctgttt tcaatgattc aaaaagaagc cgatatctcc gaaacttcca agatatcaat
    17941 cttacagcct cttgaccagg aagcaggcgc aagcatgacc gcggcgatga gcgacgatga
    18001 aatcatctgc ggctgcaacg gtgtatcaaa aggcgcgatt attcaagcca ttcaggaaaa
    18061 aggctgcaca tcaacggacg aaatcaaagc atgcaccggg gcatcccgtt cctgcggagg
    18121 ctgtaaaccg ctcgtggaag acattcttca atatacactg ggctcagaat ttgacgcgtc
    18181 cgcgcaaaaa gaagcgattt gcggctgcac ctcactgtcg agagatgaag tcgtagaaga
    18241 aatcagagcc aaagggctgt cccatacaag agaaatcatg aacgtgctcg gctggaaaac
    18301 gccggagggc tgctccaaat gccgtcctgc cctcaactac tacttaggca tgattaatcc
    18361 ggctacatac gaggatgaca gaacatcccg ttttgtgaac gaacggatgc acgccaatat
    18421 tcaaaaagac ggaacatact cagtcgtgcc ccgtatgtac ggcggcgtga ccaactctca
    18481 ggatctccgc aagatcgccg atgtcgtcga caaatatgag atcccgctcg ttaaaatgac
    18541 cggcggccag cggattgatc tcatcggcgt caaaaaagaa gacctgccga aagtatgggc
    18601 cgagcttgat atgccgtcag gctacgcgta cggaaaaaca ctccgcacgg taaaaacgtg
    18661 cgtaggcgaa caattctgcc gcttcggcac gcaagactcc atggcactgg gcattgcgct
    18721 tgagaaaaca ttcgaagggc tcaatacgcc tcataaggtc aaaatggccg tgtccgcctg
    18781 ccctcggaac tgtgcggaat caggcattaa ggaccttggc gttgtcggca tcgacggagg
    18841 ctgggagctt tatgtcggtg gaaacggcgg aacccatttg cgcgccggtg atttgctgat
    18901 gaaagtaaaa acgaatgaag aagtcttaga atatgcgggt gcttaccttc agtactacag
    18961 agaaacggca aactatctgg agcggacatc cgcatggctt gagcgcgtcg gtttatctca
    19021 tgtccaatcc gtattaaacg atccggaaaa acggcaggag ctcaacgaca gaatgaatga
    19081 aacactctct gttcacaaag atccgtggca atacttcctt aaagataaaa aagcatctaa
    19141 agatctattc gaaaatgtcg tcacgacttc ataaaacagt aagggggaac ggacatggtt
    19201 aataaagata tgacaaaggt ttgcataggc aaagtaaacg aattaccgga ggagttagga
    19261 aaaaccgtat atatagaaga taaagagctt gccgtattta agctttctga cgggagcgtc
    19321 cgcgccgtcg aaaaccgctg tccccataaa gggggcgtcc tggctgaagg catcgtcagc
    19381 ggagaatacg tcttctgccc gatgcatgac tggaaaatct ccttagaaga cggaaaagtc
    19441 caagagccgg atcatggctg tgtcaaaaca tacgaaacac tgattgaagg agagaatgta
    19501 tacctcctgt attgagcaaa gaccggatca ctttttcaag tggtccttca ttttttaaat
    19561 tgctgaaggg atgacgccat catgaaaaac ggaatcgtat attttgtcgg tgccggacca
    19621 ggagacccgg ggctgatcac cgtaaaagga aaacaggctc tggagaaagc ggatatcatt
    19681 ttgtatgacc ggctcgcaaa cccaaagttt cttgaatatg cctcaccgga ctgccggttc
    19741 atttattgcg gaaagctgcc cgaccgccat tttatgaaac agtctgagat aaatgccctg
    19801 ctgattgaaa aagcggcgga gggctgcacc gtcgtccgct tgaaaggcgg agacccaagt
    19861 gtgttcggca gagtcggcga agaagcagag gcgcttcatc agcacggcat ccgctacgaa
    19921 atggtgcccg gcatcacctc gggaatcgca gcgccgctgt atgcgggagt ccccgtcacc
    19981 catcgtgatt tcgcttcgtc cttcgcgatg atcaccgctc atgatacatc attgcaaggc
    20041 aggccgaatc tcgactggga agggcttgcc cgaagcgttc aaacgcttgt gttttacatg
    20101 ggcgttaaaa atctgtcatt tatatgccgg cagcttacgg agtacggaaa atccccttcc
    20161 gttcccgtac tcgtcattca atgggggacg tgggggcggc agcggagcgt taaaggaacg
    20221 cttcaggaca tccatgaaaa agttcaaaac caaaacatca ccaaccctgc cattatcgtc
    20281 atcggtgata ttgtcaattt tcaaacacac agctggtttg aaagcaaacc gttcatcggg
    20341 cggcatatca tggttgtcac tcatggcgat gaagaacata cactgacaga caagctgcgc
    20401 gagtatggcg ccgatgttat tgaatggccg aagcggatcg ttaaaaaaat gcccgcaaac
    20461 gaaaacatcc tgaaacagat cagcaccttt gaacaactat ttttcacatc acgccttgcg
    20521 gtatgcgaat tctttgacac actggctttc aagcagatcg acatccgccg ggtgaccgca
    20581 agcctgaatg cagcgactga agccgcaaag acggaactga caaaacgggg ctttctccta
    20641 tccgaatgtc aaattgattc tccgcattca ctcattgtag gaagccgtca agcagcagaa
    20701 aacttgtcag actcaaaatc atgcccgctt tatatcaccc atgaacatat cgcggatgag
    20761 cggttcactt ccatgattga acgcacgatc agtgagtctc ctctgcaaat gattatctgt
    20821 acgggcaaag aatccgctca gcatttgatc agcgccggaa aacaaatcgg catatcaccg
    20881 gatccgtcgg caaaccgccc tcccgtcatc tgcatgggcg aagacgtccc cgccggctgc
    20941 gggtttaccg ctgtgaaaaa ccaggagcag ttatttgcgt ttatacgaaa tgaaatgaaa
    21001 gacatgctcg ttcacagctg atacgccgga atgcttttct gaccccccag actcaacatc
    21061 gggggtcagc cttttttatt gtgtcaccaa ttttttatgg tgagtcgaat acatcgccat
    21121 ctgatccgcc tgcgggtcca aataggcttt ggcgctgttc acggcggtcg gcccctccgt
    21181 gaaaccgcct gcaatcaatc tgagcttgct ttcataatgg gcggcgtcac cggcgacaaa
    21241 cacgcccgga agattcgtcc gcatatgtct gtcagcttta atcctgcctt cttctatctc
    21301 aagcccccag tccttcatcg ggccgagatc aattttaaac ccgtggttga taatgagctc
    21361 atcaagcttg atgacttcag aaagtccgga ctcagtttgg caaacggtga cgctctcgat
    21421 ccgttcccct gtgccgttga gaagcttcag acgatacggc gcaagcaccc gcacggaaga
    21481 ccgcttcatt ttcgccacgc tgctttccaa accgccgaac tcctccctgc ggtgcaaaac
    21541 ggtaacagac gccgcaatcg gttccagctc attcgcccag tcaaccgcag tatctccccc
    21601 tccggaaatc acgacatgct tatctcgaaa cgcatcaagc ttctccacct tataatgaag
    21661 gttctttcct gaataacggc tcgcatccgc gctgtcaagt tcattaacct caagcgtccc
    21721 catgccgacg gccaaaatca ccgtgcgcgt atagtgcttt tccccttcgg aactttcgag
    21781 cacaatggtt ccgtcttcca gccgttcaaa tccggtcacc cgctgattca acacgatatc
    21841 cggctcaaat gtcgccgcct gctccttcag ctgcttaatc agctgttccc cggcaatccc
    21901 gggtattccg ccgatatccc ggatgatttt ttcaggaaaa aacatagaca cctttccccc
    21961 gagccgcggc aaaaactcga tcactttcgt tttcagctcc cgcatcccgc aataaaaagc
    22021 cgcaaacagg ccgatcgggc ctccgcctat aatcgtgacg tcgtacacct catgattttc
    22081 cgccatcgtt gtgcctcccg ttatatctat acttcataca tttttaattg agaatcaata
    22141 tcaatgaaag tataacacat attgaggatc agtgtttatt catttctcat cttgcgggaa
    22201 aggagtgatt cagaagtgag gttctgagat tgataagcgg gaaggtatta aaactgaaac
    22261 cagtacggcg actggtttct tttttatctc tttttcatca gcatgatatc gagatacagc
    22321 tggcaccttg tcctgaagtc gtttaaatta attgatgtca tgtcaagaat ctgtttgatg
    22381 cggtagttca atgtgttttg atgaataaaa agctgttctg cggctggttt tgttttgcag
    22441 ttattgagga gatagatttc taacgttttc agcagttcgg tgctgctttc tctgtctttg
    22501 gcttttaata acgctaaatc atcgtttaca tattccagtg aggcgttttt ttcttcgatg
    22561 ctttcaagat agcggtaaat cccgagctta ctgtattcgt acgggatatt ttcctgattt
    22621 ccggtaattt cggcggcctt tatgacttca agggcttcta tataactttt cccgagcttc
    22681 aggatgctgc tgtattcatt gccgattccg atatagatgg gagtggggat cttctgaaag
    22741 tgaaaatgag tcagcagttt gtggatgaat tcagatgctg ccgaagtgcc ggagcttttt
    22801 tgcgagaagc ttgcgacgac gatgacaata ttggaatcaa tggttaagac gtgactgact
    22861 ttatcccgca aattcaagta cgatttgata ttttccttta catcttcgac tgcctcccca
    22921 tccccatttg cggcatgcag gacgactacc gaaaaaaccg acggcagcac ggcgttcatc
    22981 ttttccgctt cccgcctgaa ctccttttca gaggagaatt gctgaaagat cgcccgtttc
    23041 accaggtctt ccgctctctc ttctttttcc tgtttcagcc ggttcgtttt atagatgatt
    23101 tttccgacat ggaatgaagt ttcatataaa aaatcgagct cctcgtccgt caagtttcgg
    23161 tcgagctcct gaatccagat gtagcccatc acttcccctt tatgttttgc gcttacaacc
    23221 actctctgat tcagtccgat actgtctatt ttttcgacac ggaacggttc aggaacggtt
    23281 ttcagctttt cgatcacccc gtccttcaga aacctttcaa aaatctgcac ggggcatttt
    23341 tttgagaata tcgtctgctg gttggcggag tcgaagtgat taatgtaata agaattatag
    23401 gcaagcaaaa agaaatccgc gctttccaga ataacgggct tctgcaattc ataactgatg
    23461 aaatcaatta atttatcaat gtccgtaaat gaaaaaactc tctctaaaag ctcttccata
    23521 cctatttctc ctatgctctt tttatcttta tcatactctg aggggtgact ttttgtatag
    23581 aaaaaaattc atatactccc aaaacggaat gatccgaaag cctgtatcgt gaaaagagga
    23641 aaaagggcgg tcccttcttc ctctcgttcc ttgcttttat tgagaaagtg tatcacggta
    23701 gtcatgaaac tgatctgtga catcttttga cggagcctgt gtcaataagc tgacgacaaa
    23761 tacagcggca aggcttacag caaagcccgg aatgatttcg tacaaaaagt ctgaaagacc
    23821 ggcattcgcc caaatgatta cggtaatcgc tcccgcaatc atgccggcga gtgcccccca
    23881 tttcgtcatc cgtttccaaa ataaactgag cagtacgacc ggcccgaatg aagcgccgaa
    23941 tcccgcccat gcatagctga caagaccaag tatcgtgttg tttttctccc aggcgagcac
    24001 cagagcgacg attgacaccg caagcactgc cattctcccc agaaatacga gttccttatc
    24061 agaagctgaa cgcctgaaca tggacttata caagtcctcc actaaagaac tggacgtaac
    24121 gagcagctga gacgaaatcg tactcataat ggccgctaaa atcgcagaaa tgagaaatcc
    24181 cgtaataatc gggtggaaca gaatgttgcc gagctgaata aaaatggttt ccggatcatc
    24241 cagcttcaac ccgcgctggt ggtaatacgc gattcccgca agacccgtaa acagcgcgcc
    24301 gagtgcagac aaaatcatcc atcccattcc gatccgtctg gcgcgtttga tctctttcac
    24361 agatgtgatc gccataaagc gcacaataat atgcggctgc ccgaaatagc cgagccccca
    24421 cgcaaataaa gaaataatgc caaggacggt ggtccctttg aacatattaa acagttccgg
    24481 gttgacggaa cggatatcgg caacggtttc tcccgggccg cccgtatgga aaatcgtcac
    24541 aatcggcacg agaataagcg ccgcaaacat aatgatccct tggacaaagt ccgtccagct
    24601 taccgccaaa aagcccccga acaaggtgta ggcgacaacg acgcctgtca cgacccacag
    24661 tcccgtgtgg taattcaacc ctaaaatgct gttgaataag acgcctccgg ataccatgcc
    24721 ggatgatacg taaaatgtga aaaagacgag aatgacaaga cccgaaaaca gtctgagaag
    24781 cttcgtatga tcaccgaaac gattttcaag gaaacccgga atggtgatgg aattccccgc
    24841 tttttcagta tacgttctca gcctcggcgc cacgaaaagc cagttcgccc atgccccgag
    24901 cacaagcccg atcacaatcc aagcgccgct taatcctgtc gagaacatgg cgcccggaag
    24961 ccccatcaag agccatccgc tcatatccgc cgctcccgcg ctgagcgctg tgacggcagg
    25021 gcctaaagaa cgccccccga gcatgtaatc cgtcagattt gacgtccgtc tgtaggcgaa
    25081 ataaccgata aacagcatgc ccgccatata aatacaaatg gaaataatca actgaatgtt
    25141 tgctatggca tttcctcctc cgctttatat gtttatggtg aaatggacac cccccgcgag
    25201 gaggatgccc attcagtccc tcttaaaaca tttcactgat tgttttcgcc tgcatgtgga
    25261 gggccaaata atccgggccg cccgcttttg aatcagtgcc ggacattttg aagcctccga
    25321 acggatggta gccgacaatc gctcccgtac aattgcggtt gaagtacagg ttgccgacat
    25381 ggaattcctg tttcgcccgt tcaatatgtt tgcggttgtt tgtaataacc gcgcctgtca
    25441 gaccatattc agtattattt gccacttcta aagcttcatc aaagtttgac actttagaaa
    25501 atgcaacgac aggcccgaaa atttcttcct gcatgagtct ggctttcgga tcaaggtcag
    25561 cgaagatcgt cggcttaata aagtagcctt ttgaatcatc tccggtgccg ccgcttacta
    25621 aacggccttc ttcttttccg atttcaatgt agctcatgat cttgtcgtaa gaaccttggt
    25681 cgatgacagg tcccatatac acgtcagcgc tgtcagggct tgccgtcact tttgattcag
    25741 tgatttcgat gacgcgctct aatacttgat catacacttt ttcatggaca actgcacgtg
    25801 aacctgcaga acatttttgt cccgcgaagc cgaatgctga tgtaaagatg gattgagccg
    25861 ccaattcaat gtccgcatct tcatcaacga caaccgtatc tttaccgccc atttctgcaa
    25921 tgacgcgttt cagatgctgc tgtcccggct gcactttcgc cgcgcgttcg aaaattctcg
    25981 taccgacttc acgtgatccc gtaaacgtaa tgatgcttgt tttcgggtga tcgacgaggt
    26041 agtctcccac ttccgctccg cttcccggca caaagttgac aacgcccttc ggaagacctg
    26101 attcctcaag cacttctacg aatttcgccg cgatgaccgg tgtcgcgctt gccggtttaa
    26161 gaacgaccgt gttgcccgtt acgatcggtg ccaccgtcgt tcccgccata atcgcaaaga
    26221 ggaagttcca tggcggaatg acgaccgtta cgccggttgg tgtgtagaca tattggttct
    26281 tctcgccgtc gcggctgttg accggcttgc cttttgccaa ttcaaccatc tggcgcgcgt
    26341 agtattccat aaagtcgatg gcttccgccg tatccgcatc agcttcgttc caaggttttc
    26401 ccgcttcctt gacgagcagg gcggagaatt cgtgctttct gcggcggact ttggcagctg
    26461 cgcggaacaa aacggccgct ctttcttcag gggaggtgta tctccactct tcgaacgctt
    26521 tcgcagccgc ttcaatcgcc tgctcagcgt gctcctggga cgcctttgac acttttccga
    26581 cgacttcttc tttgtctgca gggttaatgg atacgatttt cgcttcagtc tctacctttt
    26641 caccgttgat gacgagcgga taatcttttc ccagatactc atttaccttc gcaagcgctt
    26701 tcttaaattc ttcaacgttc gattgatctt ggaaattcgt gaatggttcg tgtttataag
    26761 gtgtagtcat tgtcatctct ccctttttta cttcttagtc attcctttaa aggcgaatgc
    26821 gatgtttgag gggcgttcgg cgagccgtct catgaaatag ccgtaccagt catccccgta
    26881 aggcaggtag actctcatgc ggtatccttc ttccaccagg ctgagctggg tttgcgagcg
    26941 catgccgtac agcatctgaa actcaaaacg gtcgtttgga atgccgtgct cttcggcaag
    27001 ctgttttgta aactcgatca ttttgtcatc atgcgtggcg actgccgtat aatgtccttt
    27061 taaaagctgt ttgcggatga gtcttttata attttcatcg acgtcgcttt tttcaggata
    27121 ggccaccttt tccgattctt tataggcccc tttgacaagc cgcagaaacg gattcagcgg
    27181 gctgaggtca tcaagatcct tctccgttct gtacagataa gcctgcacca cggtgcttac
    27241 atattcatac cggcttcgga agtctttaaa gatatccagc gttttctggc atctcgtttc
    27301 atcttccatg tcaatcgtca ccatgacttt atgtttttca gccgtctgga ggattttcgt
    27361 catattttca tagacgagat cgagatctat atcaagacct aaagacgtca tttttaatga
    27421 cacttgggaa ttcagctgtt catcagcaat taaggcgatg gtctgcatgc actcctcggt
    27481 gcgttctttc gcgacgtcac cgctgttgac aaattccccc aaatgatcga cagtaactga
    27541 cagcccctgg ctgttcaaat gtcggattgt cgggatagaa ctgcggaaat ccattcctcc
    27601 gatgattttg ccggctgcca cacggcttcc ccagcttcgc gccatcttat tgagaaagct
    27661 gctcttggat aaaaataaga aaaaatctct tgtaatcact tccaacctta acaccccgca
    27721 atctaagaag tatttgtatg agtctattgt aaatggacaa aacatcctct cgcaatattc
    27781 taaaaataca aagattctga taaatttttg tggttttacc acaatcagct tcttagatag
    27841 caggcggatt atgccgaaaa aaggcggacg gaaatgacgg caatcgtcaa tttccgcctt
    27901 tttcccccca cgcctcttcg acggtctgaa tcaatagctg attcagttcc tccgttatgt
    27961 caggtttcgg cgttt
//
