LOCUS       NZ_JAQDYA010000010     20858 bp    DNA     linear   CON 22-FEB-2024
DEFINITION  Lactococcus lactis strain AM113-80 PF3HH22005.Scaf10, whole genome
            shotgun sequence.
ACCESSION   NZ_JAQDYA010000010
VERSION     NZ_JAQDYA010000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lactococcus lactis
  ORGANISM  Lactococcus lactis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Lactococcus.
REFERENCE   1  (bases 1 to 43334)
  AUTHORS   Lin,X., Hu,T., Chen,J., Liang,H., Zhou,J., Wu,Z., Ye,C., Jin,X.,
            Xu,X., Zhang,W., Jing,X., Yang,T., Wang,J., Yang,H., Kristiansen,K.,
            Xiao,L. and Zou,Y.
  TITLE     The genomic landscape of reference genomes of cultivated human gut
            bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 43334)
  AUTHORS   Zou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-NOV-2022) BGI Reaserch, BGI-Shenzhen, Beishan
            Industrial Zone, Shenzhen 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: MGI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/22/2024 02:49:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,400
            CDSs (total)                      :: 2,354
            Genes (coding)                    :: 2,325
            CDSs (with protein)               :: 2,325
            Genes (RNA)                       :: 46
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 38
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 29
            CDSs (without protein)            :: 29
            Pseudo Genes (ambiguous residues) :: 0 of 29
            Pseudo Genes (frameshifted)       :: 9 of 29
            Pseudo Genes (incomplete)         :: 18 of 29
            Pseudo Genes (internal stop)      :: 7 of 29
            Pseudo Genes (multiple problems)  :: 4 of 29
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:07:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 20479
            Orig. end                         :: 41337
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQDYA010000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20858
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20858
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20858
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10858](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10858)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(358..375)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     misc_feature    complement(934..948)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.12"
                     /tool="antismash"
     gene            complement(2275..2655)
                     /locus_tag="PGT72_RS10930"
     CDS             complement(2275..2655)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131357.1"
                     /locus_tag="PGT72_RS10930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cell division protein FtsL"
                     /protein_id="WP_003131357.1"
                     /transl_table=11
                     /translation="MAAQPKEYFDIETAAKKDSYLIDTETLAPEVLASKFKKFSGVEKV
                     FYLTMVVAALVLAVGLLYVKTKTLEVQGNTMDLRSKISQETTRKTEYDQQILDLTSGTK
                     VLDTANKADLKQNPSNVLKATK"
     gene            complement(2813..3766)
                     /gene="rsmH"
                     /locus_tag="PGT72_RS10935"
     CDS             complement(2813..3766)
                     /EC_number="2.1.1.199"
                     /GO_function="GO:0016434 - rRNA (cytosine)
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864364.1"
                     /locus_tag="PGT72_RS10935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="WP_017864364.1"
                     /transl_table=11
                     /translation="MPKTIAFKHDTVLLHETVDMLEVKPNGIYVDATLGGAGHSEYLLS
                     KLTNGHLYSFDQDETAHENAKVRLSEQLAEDKVTLIKSNFRYLKSALAELGVTKIDGIL
                     YDLGVSSPQFDDSQRGFSYKKESRLDMRMDQNQTLSAYEVVNDYPYEALVRIFFRYGED
                     KFSKQIARKIEQARKIKPIETTIELADLIKSALPQKELKKKGHPAKRIFQAIRIEVNDE
                     LGAAEESIEQAIDLLKVDGRISVITFHSLEDRLTKTIFKEYSTVNVPKGLPMLPKDMEA
                     KLKLINRKPVLASEEELEFNNRAHSAKLRVAQKQRD"
     misc_feature    3850..3863
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.27"
                     /tool="antismash"
     gene            complement(3986..4924)
                     /locus_tag="PGT72_RS10940"
     CDS             complement(3986..4924)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864363.1"
                     /locus_tag="PGT72_RS10940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF805 domain-containing protein"
                     /protein_id="WP_270342993.1"
                     /transl_table=11
                     /translation="MVQAYKKFRLGAFTFNKKTSRKDFWSALLTHIIIFVILFKAYHFF
                     NLLDFYQLTTLWQTFASFFQLIFNLYFFGSLLSFIALTVRRLNDADLPWGLIFLNFILG
                     LGTLVLLILNLFPSSPRALKFKEYEISSSQEFNNLPETKTLSGIFKDYFKNYFEFRGRT
                     TRRNFWWIQLFWGLTVILFLFLIYLFNQFEQIMFGYNFIGSMVLRLLFFLFLLGTFFPQ
                     LTIHVRRLRDAGLSNLGLSLLLGGTSGILIFYQMFTKTLKITYTTGHYQLVQYLLFLLV
                     MIALLSLILVEVMATGELKTNKKNSLFEKID"
     gene            complement(4947..5468)
                     /locus_tag="PGT72_RS10945"
     CDS             complement(4947..5468)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015426163.1"
                     /locus_tag="PGT72_RS10945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF805 domain-containing protein"
                     /protein_id="WP_003131354.1"
                     /transl_table=11
                     /translation="MIKAYIKYWKKAGDLKSYSNRSDYWWVFLTNSIIFAILSILNFMV
                     TIPKAGKIMSQSATLSQKEIIQQVTDLYANPTGGALVIVIVTALIGLAILVPNISLTAR
                     RLRDARFPWWIALVFGVAAIYGLVTMFIHQDLLAKMGYFVGFINFIIYILCLFPTKYGI
                     DEEDDSRTYE"
     gene            complement(5566..6132)
                     /locus_tag="PGT72_RS10950"
     CDS             complement(5566..6132)
                     /GO_process="GO:0071805 - potassium ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011675826.1"
                     /locus_tag="PGT72_RS10950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TMEM175 family protein"
                     /protein_id="WP_003131353.1"
                     /transl_table=11
                     /translation="MSKTRLEAFTDAVIAIIMTVLVLELVRPDSDSLQSFIALLPHLGV
                     YFVSFFILAIYWVNHHHLFQSIKRINGKVLWINISFLFVLSLIPIFSNWVSIYPNSFIP
                     ELGYVIIFFFGNFIYLLLTRELLKINGHRKTSETTIRKNILSVVLNIVSILLGYFIAPV
                     IMLVGSALIFSMWVIPDKNIEKMFK"
     gene            complement(6858..8525)
                     /gene="recN"
                     /locus_tag="PGT72_RS10955"
     CDS             complement(6858..8525)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019292004.1"
                     /locus_tag="PGT72_RS10955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA repair protein RecN"
                     /protein_id="WP_017864362.1"
                     /transl_table=11
                     /translation="MLQEISIKNFAIIEEIHLSFESGMTILTGETGAGKSIIIDAMSLL
                     LGGRASSDFVRHGANKAEIEGLFFFDKTPELKAVLLELGFEEVDSEIILRREIFANGRS
                     VCRINGQMVNLATLRQVGELLVDIHGQHDSQELMNPKSHLRLLDEFGDEAFDQIKNNYK
                     LKFENFKNLRQQLNLRQKNEQEFAQRIEILQFQAEEIEAAEINLEEDEQLINRREKLNN
                     IKNIADSLSSAYLALDDEDNDYSSLNNIRTTMTELDKISNFDNDYQELADKTAESYYVL
                     EEVANQIQRIMSDLEFNPAELLQIEDRIMTLTTLKKKYGPELSDVMNYLEKVQLELSEL
                     TGSENDSENLENSVKVAQVQLIEASKKLNEARHKIAKEVEKDIKHELSELYMEKADFKV
                     SFEGAKFSANGNEHVEFFIQTNPGEGFKPLAKTASGGELSRLMLAIKSSFSRRENKTAI
                     VFDEVDTGVSGRVAQAIANKIYKIARHGQVLAISHLPQVVAIADRQFYIEKASTDDITT
                     STVRKLNAEERVNEIAKMLAGEDLTKEALAQAKRLLSK"
     gene            complement(8673..9119)
                     /locus_tag="PGT72_RS10960"
     CDS             complement(8673..9119)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015426160.1"
                     /locus_tag="PGT72_RS10960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arginine repressor"
                     /protein_id="WP_003131351.1"
                     /transl_table=11
                     /translation="MKREDRLNFIAQFIRENEIKTQEELVNTLLTHGIDVTQATVSRDI
                     KSLALIKVPAESGGYRYDLPKNKEVLQSSLHKALAFDAITGTKIKDNMLWILANPGTTS
                     LVKNYLLEEYSDDIFSIIIDDDSALVIFEMEEDAKNLYNLLTEF"
     gene            complement(9116..9922)
                     /locus_tag="PGT72_RS10965"
     CDS             complement(9116..9922)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131349.1"
                     /locus_tag="PGT72_RS10965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_015426159.1"
                     /transl_table=11
                     /translation="MKERIDVLATNQGLFETREQAKRGVMAGLVVDSKSGERYDKPGQK
                     IDDGTELRLKGEKLRYVSRGGLKLEKALKEFHLEINGKTCLDIGSSTGGFTDVMLQNGA
                     KLVYALDVGTNQLAWKIRSDERVVVMEQFNFRNAVLADFEQGRPSFTSIDVSFISLDLI
                     LPPLYEILEENGEVAALIKPQFEAGREQVGKNGIIRDPKVHQMTIEKVLKTATQLGFSV
                     KGLTFSPIKGGAGNVEFLVHLLKDGKAEIAQQVNIESVLQKESEEL"
     misc_feature    complement(9935..9948)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.74"
                     /tool="antismash"
     gene            complement(10001..10858)
                     /locus_tag="PGT72_RS10970"
     CDS             complement(10001..10858)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897509.1"
                     /locus_tag="PGT72_RS10970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_012897509.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.6e-55, bitscore:
                     178.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKILKLEDFLTEFYESAEFPTGLAESAKYSLLAGGKRIRPLLF
                     LNLLEAFDLELSKAHYHVAAALEMIHTGSLIHDDLPAMDNDDYRRGQLTNHKKFDEATA
                     ILAGDTLFFDPFFILSTADLSAEIIVALTRELAFASGSYGMVAGQILDMAGEGKELTLA
                     EIEQIHRLKTGRLLTFPFVAAGIVAQKSTDEVEKLRQVGQILGLAFQIRDDILDVTATF
                     AELGKTPGKDILEEKSTYVAHLGLEEAKKSLTGNLSEVKKLLTDLSVTDSSEIFKIIEQ
                     LEVK"
     gene            complement(10940..12097)
                     /locus_tag="PGT72_RS10975"
     CDS             complement(10940..12097)
                     /EC_number="2.7.1.31"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008887 - glycerate kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864361.1"
                     /locus_tag="PGT72_RS10975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycerate kinase"
                     /protein_id="WP_058211854.1"
                     /transl_table=11
                     /translation="MKKKFVLAPDSFKESLSALEVCQAMEKGIKKVFPKAEIISMPMAD
                     GGEGTTDALIDATGGRRVYKKVQGSFANTNVEAYFGILGNSNTAVIEMAKANGLELVAL
                     EDRNPLITSTYGTGQLIKAAMDEGVDKIIIGIGGSATNDGGSGMARALGAKFLNKDQEE
                     IPLGGGFLKEVRTIDMSDFDPRVEEIEILIATDVTNPLTGNNGASYVFGPQKGATEEMV
                     KVLDENLKHYAEIVHNDLGKDIKNKPGAGAAGGLGAGLLAFTNAKMQLGIELVAQTIYL
                     EDKIKEADYVFTGEGGMDYQTKFGKAPYGVCKIAKKYKKPCFALAGYIGDGADVLYDEG
                     MTAIFGVLSQAQSLSDALADGAKNVERTSENITRVLAMNEQKAHL"
     gene            complement(12246..12485)
                     /locus_tag="PGT72_RS10980"
     CDS             complement(12246..12485)
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131346.1"
                     /locus_tag="PGT72_RS10980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_003131346.1"
                     /transl_table=11
                     /translation="MATKKEDVKFEDNLAELENIVRKLESGDVALEDAIAEFQKGMKIS
                     ETLKKTLNEAEETLVKIVGKNDQESDFSPEQKDY"
     gene            complement(12485..13738)
                     /gene="xseA"
                     /locus_tag="PGT72_RS10985"
     CDS             complement(12485..13738)
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131345.1"
                     /locus_tag="PGT72_RS10985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_017864360.1"
                     /transl_table=11
                     /translation="MTEYLSVSTLTKYLKAKFDRDPYLERVYLTGEISNFRRRPNHQYF
                     ALKDEGAVIQATMWAGQFRKLDFELEEGMKVLAVGRISIYPPSGSYSINIESLVPDGVG
                     ALAVKFEQLKKKLTAEGLFEQRWKQTLPQFSKKIAVVTSPSGAVIRDIITTVQRRFPMS
                     QIVLYPTKVQGQGSAEEIAGNIRRANQRGDFDVMIIGRGGGSIEDLWGFNEEIVVRAIF
                     ESRIPIISSVGHETDVTLADFVADSRAATPTAAAELATPNTKVDLINWANEQEKRLFNR
                     LTHLIKIRRERVDKLSQSVVFRQPERLYDGHLQKLDRLCERLSVLTENKVANMKHRFEL
                     SAGKLIPTYGKIVEAKKNKTEQLYQSLLLLDISKIKARGFSLVTDEKGKIIKSVSDVKK
                     GQTLDVELTDGKVIVEVK"
     gene            complement(13905..14759)
                     /locus_tag="PGT72_RS10990"
     CDS             complement(13905..14759)
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131344.1"
                     /locus_tag="PGT72_RS10990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="WP_017864359.1"
                     /transl_table=11
                     /translation="MNLIDGKALAAKMQAELKVKVDKLKEADNVPGLAVILVGEDPASQ
                     IYVRNKARQATAIGLNSSVVRLPETVSEQELLDLIEQYNQSEQWHGILVQLPLPEHISE
                     EKVLLAIDPEKDVDGFHPMNMGRLWSGNPLMIPSTPAGIMEMFREYNVELSGKRAVVIG
                     RSNIVGKPMAQLLMMADATVTIAHSKTENLRELTKEADILVVAIGRDRMIKAEDVKKGA
                     VVIDVGMNRDEDGKLHGDVDFDEVKDVASLITPVPGGVGPMTITMLMEQTVRAASRKMN
                     ENK"
     CDS             complement(14919..>15559)
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015426153.1"
                     /locus_tag="PGT72_RS10995"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="SSNSSESSVASSSSVDSSQSSSAGVNGSSSSSEGSSASSLSSSES
                     SMTSSGGTSDSNSNTGQTSTTSSSSENSSHSSLSSNESSSASLTSSESSGLTTSSSMLT
                     NPNLQSNDKNGSSLTSNSSYTSEMKLNNLSDSNLPSNESKVSTLISKVSSSPSLSNSLS
                     ATSLQLVPTVTKEELPKTGADDDLSLVLAELGLGLVATLTIGKVKYKKRF"
     gene            complement(14919..>15561)
                     /locus_tag="PGT72_RS10995"
                     /pseudo=""
     assembly_gap    15562..15571
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<15572..17865)
                     /locus_tag="PGT72_RS11000"
     CDS             complement(<15572..17865)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015426153.1"
                     /locus_tag="PGT72_RS11000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="KxYKxGKxW signal peptide domain-containing
                     protein"
                     /protein_id="WP_270342997.1"
                     /transl_table=11
                     /translation="MKKIRPEVTTVTSKSHFRTWKSGKSWLFATSALAIIIVSGTITDQ
                     NVKADTAIDSSQQISGITEVTSYSALASSTNSDVAASQNQVAYEQASDQSSNKSLANTV
                     ETDTEGITSNVSDSSYSINESQNTTSTVVIQTPTNNIVSLADSSSSNDNGSNSILSSSN
                     AADSVDSAVGSQSSTSSSGVLSESSAIDSGIASVSQSSEMNLVGNSSASASSAAVASFT
                     AILATNPSMVPMLTQALAAAAPATTSGSAILNTTLGDLVNQAISTVGISGLANIFSTLG
                     TFNIPGMTTAAAALNGVEQIVNIVGNIQEAAANPGAFLLNEIKSAGLDVSQIPLVGGQI
                     AAAFNAIPSMSPAAMLTFLENPTIPGLSSIPGASLVLSPVLSAISTVTSGIVNQLNTTT
                     SNALGGVNFDLDTLVSLQGNDLVNYLAGLVVNSAINRVGQIAWSQLSPTISNIPLVGTT
                     VNNVLSPILNNLTGASLGEVANLTGVSSLLDQVNNSLGNLTSLGSTALATIENTLQNSL
                     NSFGNLPAGASDILNQVLNQLQNAINNIVESATGIVNNLPGLGAIENGLSNTISQIQNN
                     INNFVNNALNGITTIINSLTPSVGASTVNPNSSANSSQSSSSASSSSSAASSSTSSSNV
                     SSNTSSNSSEANTSSSTSNASSSSSSSEGSSASSSNSSEGSATSSSSVDSSQSSSAGVN
                     GSSSSISSSNSSESSIASSSSVDSSQSSSAGVNGSSSSSEGSSASSSNSSESSIASSSS
                     VGSSQSSSTGV"
     misc_feature    complement(17820..17835)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.48"
                     /tool="antismash"
     misc_feature    complement(18011..18026)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: strong, score: 30.52"
                     /tool="antismash"
     gene            18071..20158
                     /locus_tag="PGT72_RS11005"
     CDS             18071..20158
                     /EC_number="7.2.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015662 - P-type ion transporter activity
                     [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0019829 - ATPase-coupled monoatomic cation
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010905590.1"
                     /locus_tag="PGT72_RS11005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WP_270343000.1"
                     /transl_table=11
                     /translation="MSNKTHSSNHDEMMSEHHHNHEIMDMEHENHEMHNMHNMDNMHDM
                     DNMDMMNHGGHMMHMGDMSKKLKVAIILMIPLLLISPIAGFTILKFPGSEILQLILGTI
                     IFFYSGTPFFSGAKGELKSRKPAMMMLITMGITVAYAYSVYATIMSLNGHMGMNFWFEL
                     ATLIVIMLIGHLIEMKAIMGAGDALKDLASLVPKKAHLKSGKDVELSELKVGDLLLVKE
                     NEKIPADGLILSQALVDESMITGESRAVNKKTNDLVYGGSLNQNQPFEMKVTTLGKDSF
                     LNQVAELVKKAQAQKSNLENMADRVAGYLFYAALIVGIFSLVFWTISSNFSFALLLAVS
                     VFVIACPHALGLAVPLVVSRLTSISAKNGLLIQNRTSLEKINTIKYALMDKTGTLTDGK
                     FIVRNVIDFTDETDILQIVAALEGSSTHPIAQSIVSAAKPLENLKVEAVENIPGVGIKG
                     QVNQNFYQIVNYKYLRENQLSYDEKKIAQYLDLGLTVSFLINEQQDVLGFIALGDSPKA
                     DAKAFINGLLAQGITPVMLTGDNKETAQKIASALNIPEFRAELKPEDKAEIVKEYQKKA
                     GVLFIGDGVNDSPALATATIGFAIGAGTSVAISTADVVLVNSNPSDVLDMINISKRMLR
                     KMKQNLWFGAGYNIIAIPVAAGILYPFTGIYIDPLIAAVLMSISTVIVSINAMGLRYDK
                     K"
     gene            complement(20208..20660)
                     /locus_tag="PGT72_RS11010"
     CDS             complement(20208..20660)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003131340.1"
                     /locus_tag="PGT72_RS11010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_270343001.1"
                     /transl_table=11
                     /translation="MKEEIDENKEKEVIQKAYKYNGLLGIWIIAVFISFLLQVAKIITD
                     SYLVWGFGLLILIYAIALHVQNHKLRIKSIASILVYSLNVLSVIGAVLIILANQAHNLL
                     ELEIGLLVGFVTVILQVLALVSALLGTRKLRKLYPDVVGNRRKNIK"
     misc_feature    20801..20815
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
ORIGIN
        1 taacagttag agtttgacct tttttaacat tggtagaagt ttcgatactt tgagtcaaga
       61 ctttatttcc tgacccttca taagttactt taattccaaa ccaattagcc aattgctcaa
      121 cttctttttt cgaccaatca tacatatcag gcatcacctg atctttatca ttcgtcaaaa
      181 gtaaaattcg tgaatttgct gaaacttttt caccttcagc aatcgattga gcagttactt
      241 ttgcccctgt cccgataata actggactaa ggacagtgcg gcgtaagcta tcagcagtat
      301 ctcctgaatc tttgccttta taattctcaa tggtcacttt gccagcttta gtatcagtat
      361 cagcactaac tgataaatca tttttcattg cttcagcact tgttaacaat ggatttgcca
      421 ctcgagcaat atatttaagt gtccaacttt ctgtaggaat ttttacattc atatagaaaa
      481 taaaatcagg attcttagca ggatacatca caacagcaga gtaaaggtaa tcttgagaac
      541 ctgtcatata accacccgtt gttgaggcaa tttgggccgt ccccgtttta accgcagccg
      601 gttcaccatt gaccataaat aaaggaccag cagcaagatt ttgctcagaa tcaccactag
      661 ttgaataaga ggtcccataa acagggtcag tatttactgt tagcatcaaa tcacgcacac
      721 cacttgctgc atcattagag accggatgtc caacaacttc tgctttagaa gtcaaacttg
      781 tttttgtatt cggatctact actttgctga caatatgtgg ctcaagcatt gttccatttc
      841 cagcaatagc cgtccaacct ctaatcaatt gaagtggagt aaccgcaacc ccttgaccaa
      901 atgaagattg aatttgcgta acggcattcg atgaaggaag agctcccgga ttttcaccat
      961 ctaaaccggc tcttacttta agaccaaatt taaatttatt aagataactt ccccataaat
     1021 cattacccat gttcatttca attttactca tcccaatatt tgaagataaa gcaaaacctt
     1081 gagcataggt tacggtttct ggcaaagtat aacttttatt ttctgttaca tcccagtcat
     1141 taatcgttgt atcataaact tgaagtttcc gttggtaagt ttcattaaga tttacttttc
     1201 cactatcaag cgctccagcc atcaagaaag ttttaaatgt tgaacccggt tcaaaggctg
     1261 attgtgagag taaactgttc caagtgaaat acttttgttt ctcagcatca ttgatcgttg
     1321 ttgccgtata ggttggacgt tgacttgttg ctaaaatctc accggtatga gcatcaacta
     1381 aagttcctga aagttgttgt gctccagtat ccgtagccgc tttgtccata tatccttcaa
     1441 gatttctttg aagttgtgca tcaagtgtag tataaacgtc ttgaccattt ttaacaggtt
     1501 caatgacttt agttgttcct ggaattgggc gaccatagat atctttttga taagtttctt
     1561 taccattttc accactcaaa acattattga aggctttttc caagcccata tcacccttga
     1621 gagcttgagt accattttca tctttaggac gagcaatacc aataaattga gaagcaaaat
     1681 ttccaaaagg ataagaacga gaaatatttg ccgtgaaacc aagtccaaca attttttcat
     1741 tctcagccgc tttttgaatc tctttcattt tttcaagaga gatatcacta cctttagggc
     1801 caaattgaac ttgtttcaat ttagaattga gctgcttttt aattaaatcg cggtcaattc
     1861 caagtttact atttaagaaa tcttcaactt tggtaaaatc tttcttatca atataaagag
     1921 gatttccatt tgaatcaacc tgtgttttat caattacagc ataaattgta taggtacttg
     1981 agtctaccgc aatagccgca cctgtacggt catatattgt tccacgcttc gcatgaactg
     2041 tttctgtgct ttgatagttg ctcttggcca tcgttgtaag attggttcca ccgacatgat
     2101 tgacggtaat tagccagaca aaacgaaata taaaaaccgt aaacagcgca atagctagga
     2161 aaaacaggct cttacctact cgtttacgat ttctttctgt actccaattc gtttttcggg
     2221 catttcgtga tacttttcta aaaggaaaga aaattagttt ttttaaaaat tttatcattt
     2281 cgttgctttc aatacattag aaggattttg ttttaaatca gctttattcg ccgtatcaag
     2341 cactttagta cctgatgtta aatctaaaat ttgttgatca tactcagttt ttcgggttgt
     2401 ttcttgagaa atttttgaac gtaagtccat tgtattccct tgaacttcaa gtgtcttagt
     2461 cttaacataa agtagaccaa cagccaacac taaagcagca actaccattg tcagatagaa
     2521 taccttttca acaccagaaa actttttaaa cttacttgct agaacttctg gcgctaaagt
     2581 ttccgtatca atgagataac tatctttttt cgccgcagtt tctatatcga agtattcttt
     2641 aggctgtgct gccatctttg cctccactcg tttatcttac taaagaaatt caacttactc
     2701 tcttcactgt taaaaagaga aaagctaaat attgttattt catttatata agacatccaa
     2761 aaacaatcct caagtgggaa aaccctcttt attagaccaa cttgttattt gattaatctc
     2821 tttgtttttg cgctactctt aattttgcac tatgagctcg attattaaat tcgagttctt
     2881 cttcgcttgc aagaactggt ttgcgattaa tcaattttag tttagcttcc atatctttag
     2941 gaagcatcgg taatcccttg ggaacattaa ctgtactata ttctttgaaa attgtttttg
     3001 ttaaccgatc ttctaaagaa tggaaagtaa ttaccgagat tcgaccatca acttttaata
     3061 aatcaatggc ttgttcgatt gattcttccg ctgctccaag ttcatcattt acttcaatac
     3121 gaatcgcttg gaaaatacgt ttggctggat gccctttttt cttgagttct ttttgaggca
     3181 atgcagattt tattaaatct gcaagctcaa ttgttgtctc aataggttta atttttcttg
     3241 cttgttcaat cttacgagca atttgtttag agaatttatc ttcgccgtag cggaaaaaaa
     3301 tgcgaactaa tgcttcgtaa ggataatcat ttacaacttc ataagcagaa agagtttgat
     3361 tttggtccat ccgcatgtct aatcttgact cttttttata agagaaacct cgttgactat
     3421 catcgaattg tgggctggaa actcctaaat cataaagaat tccatcaatt ttcgtgactc
     3481 ctaattcagc taaagctgat ttaagatagc gaaaattact tttaatcaat gttactttat
     3541 cttctgcaag ttgctcactt aagcgtactt ttgcgttttc atgagcagtt tcatcctggt
     3601 caaatgaata aagatgacca ttagtcagtt tactaagaag atactcacta tgtcctgcgc
     3661 cacctagtgt cgcatcaaca taaattccat ttggctttac ttcaagcata tctacggttt
     3721 catgtagtaa gactgtatca tgcttaaatg ctattgtttt tggcaagagc gccgtcctcc
     3781 ttgtatactt acagtttatt atatcacttt ttttctattt ttgtagtagt ttacatgatt
     3841 atgtaaagat ttttttaata aaaaggctta catgaactgc atttgtatct attactggct
     3901 tctttgatgt caattcaatt tacaagttgt gtaaacatga ctttttatag tttaacaatt
     3961 aatactaaaa atagactgaa attaatcagt ctattttttc aaataaagaa ttttttttat
     4021 tcgtttttaa ttctcctgtc gccattactt ctacaagaat taaactcaat aatgcaatca
     4081 ttactagtaa aaataagaga tattgaacta attgatagtg accggttgta tatgttattt
     4141 ttaatgtctt cgtgaacatt tgatagaaaa ttaatattcc acttgttcca cctaacaaaa
     4201 gtgatagtcc taaattactc aaaccagcat ctcttaagcg tcttacatga attgtaagtt
     4261 gtgggaaaaa tgttcctaag agaaatagga aaaataataa acgcaagacc atactaccaa
     4321 taaaattgta gccaaacatt atttgttcaa attgattgaa aagatagatt aaaaacagaa
     4381 aaagaataac ggtcagcccc caaaacagtt gtatccacca aaaatttctt cttgtcgttc
     4441 ttccgcgaaa ttcaaagtaa tttttaaaat agtccttgaa tatacctgat aatgtctttg
     4501 tctctggtaa attattaaat tcttgagaag aactaatctc gtattccttg aattttaaag
     4561 ctctaggcga acttggaaat aggttaagta tcaagagcac aagagttcct agaccaagga
     4621 taaaattaag aaaaataagt ccccaaggta aatctgcatc attcaatctc cgaacagtta
     4681 gagcaatgaa ggacaataaa cttccaaaga aatatagatt aaatattaat tgaaagaatg
     4741 aagcaaaagt ttgccataaa gtcgttagtt gataaaaatc tagtagatta aagaaatgat
     4801 aagctttaaa caagatgaca aatattatga tatgagttaa taaggctgac caaaaatctt
     4861 tacgactggt ttttttattg aaagtgaaag ctcccagccg aaatttttta taagcttgaa
     4921 ccatatttta cctctctatt ttttaattat tcataagttc ttgaatcatc ttcttcgtca
     4981 atgccatatt tggttggaaa aaggcaaaga atataaataa tgaaattgat aaatccaaca
     5041 aaataaccca tttttgctag aagatcttga tgaataaaca ttgtaaccag cccataaatt
     5101 gcagctactc caaaaacaag agcaatccac caaggaaacc tagcatcacg taaacgacga
     5161 gctgtcaaac tgatattagg aacaagaata gctagaccaa tgagagctgt aacaataact
     5221 attactaatg cgccacccgt ggggttggca tataagtctg tcacctgttg aataatttct
     5281 ttttgtgata aagttgcaga ttggctcatt attttcccag ctttagggat tgtcaccata
     5341 aagtttaaaa tgctgagaat cgcaaatatg attgaattag tcaagaaaac ccaccaataa
     5401 tccgaacgat ttgaataaga ttttaaatct cctgcttttt tccaatattt gatgtatgct
     5461 ttaatcattg ttattcctct ttacttataa tattatttac tgacagaagg tcagttattt
     5521 attccaaact tttttattaa gtaaactcat atttttatta aaagattatt taaacatttt
     5581 ttcaatattt ttatctggaa tcacccacat tgaaaaaatt aaggctgaac caacaagcat
     5641 gattactgga gctataaaat aacctaataa aatgctgaca atattgagca caacacttag
     5701 gatatttttt ctaatcgttg tctcagacgt tttacgatgt ccattgattt tcaataattc
     5761 tcttgtcaaa agtagataaa taaaattccc gaagaaaaag ataatcacat agcctaattc
     5821 tgggataaat gaattaggat agattgatac ccagttagaa aaaataggaa taagtgataa
     5881 gacaaaaaga aaactaatat ttatccatag aacttttcca ttaattcttt tgatgctttg
     5941 aaaaagatga tggtgattga cccagtaaat agccagtata aaaaaactta caaaatagac
     6001 acccagatgc ggaagtaaag caataaaact ttgtaagcta tctgaatctg gacggaccaa
     6061 ttctaaaact aagacagtca tgataattgc gatgacagca tccgtaaatg cttctaaacg
     6121 tgttttactc atttttaact cctaaattat aaaatacgac ttcagttttt aaattacaaa
     6181 cctctccttt cagtactatg gttgatatct cattataaca tattgagttt aattcataaa
     6241 agaactttaa cagaagttct taatggtaaa aaatctaatt ttacttcata atatctcctt
     6301 tggagataaa aagccccaat aaattgaggc ttcgaattta taataaaaac gcccttatct
     6361 tatataggag aaggcgtttt tatctatggc tctttgactt ggaagttggc acatagtata
     6421 taaagatatt ttagcctttt tcaaaaggct tgtcagtaac atttgctaac aactcaaaga
     6481 aatttatcta aaactagctt tttaaaattt atttttttat cttttgattt ctaagaattt
     6541 ggatcagcat ttcgcataac atacagatta ttcccgcaca ggcaccaata atacctacga
     6601 acaagaaaaa ataattttga ttataatgcc cataaattga aaaaaacaaa cagaccaaaa
     6661 tgattaaaat ccaaatttta tttactttca catatactcc aatattttta atagtgtaac
     6721 tacaatttaa ttttaacatt tattattttc ggtatataca catttgtggt tgcagtttta
     6781 cactaattat gattttgtca tctaaaagat aaaaagccct gattaaaaat caagactttt
     6841 tcttaataat attcgattta tttgctcaat aaacgtttag cctgagctaa ggcttcttta
     6901 gttaaatctt caccagcaag cattttcgca atttcattta ctctttcttc agcgtttaat
     6961 tttctaactg tggaagtagt aatgtcatcg gttgaagctt tttcaatata aaattgtctg
     7021 tcggcaatgg ccacaacttg cggaaggtga gaaattgcaa gaacttgccc atgtctagca
     7081 attttatata ttttattagc aatcgcttga gcaacacggc cagaaacacc agtatcaacc
     7141 tcatcaaaaa caatggctgt tttattttcg cgtcttgaaa agcttgattt tatggcgagc
     7201 attaaacgtg aaagttcacc acccgaagct gtttttgcca gcggtttaaa tccttctccc
     7261 ggattggttt gaataaagaa ttcaacatgc tcattcccgt ttgctgaaaa ttttgcccct
     7321 tcaaaactaa ctttgaaatc agctttttcc atataaagct cagaaagttc gtgtttaata
     7381 tctttttcaa cttctttggc aattttatgg cgcgcttcat taagtttttt acttgcttca
     7441 atgagctgaa cttgtgcaac tttaactgaa ttttctagat tttctgagtc attttctgaa
     7501 cccgtcagtt ctgagagttc aagttggact ttctctaaat agttcatcac atcggacagt
     7561 tctgggccat attttttctt caaagtggtc aaggtcataa tccggtcttc aatttgtaaa
     7621 agttcagctg gattaaattc taaatcactc atgattcttt gaatttgatt agcaacttct
     7681 tctaatacat aataactttc agctgtcttg tcagcaagtt cttgatagtc attatcaaag
     7741 ttactaattt tatccaattc tgtcattgtt gttcggatat tattaagact tgaataatca
     7801 ttatcttcat catcaagcgc tagataagca ctactaagcg aatcagcaat atttttaata
     7861 ttatttaact tttctcggcg attaattaat tgttcatctt cttcaagatt aatttccgcc
     7921 gcttcaattt cttcagcctg aaattgaaga atttcaattc tttgagcaaa ttcttgctca
     7981 tttttttgtc gtaaattgag ctgttgacgc aaatttttga agttttcaaa tttgagtttg
     8041 taattatttt ttatctgatc aaaggcttcg tcaccaaatt catcaagtaa acgaagatgg
     8101 cttttcggat tcattaattc ttggctatcg tgttgaccat gaatatcaac taataattca
     8161 cccacttgtc ttagcgtagc taaattaacc atttgaccat tgattcgaca aacggaacga
     8221 ccattagcaa aaatctcacg tcttaaaata atttcagaat ctacttcttc aaagccaagt
     8281 tctaataata ccgccttcaa ttctggagtt ttatcaaaga aaaagagacc ttctatttcg
     8341 gctttgtttg ccccatgccg cacaaaatca ctcgaagcac gcccacctaa taataaagac
     8401 attgcatcaa taattattga ttttcccgca ccagtttccc cagttaaaat cgtcattcca
     8461 ctctcaaagg atagatgaat ttcttcaata attgcaaaat ttttgattga aatctcttgt
     8521 aacatcaaaa tttcctttct caaaaataaa tgacaaggct attagtaacc caataacctt
     8581 atctttccta ctttgattct ttttttactg acagctatta attcgctcaa aatattcagc
     8641 agaattttgt cacaatattc ttgtcagtaa atttaaaatt ctgtcagtaa attataaaga
     8701 tttttagcat cttcttccat ttcaaaaata actaaagcac tatcatcatc aataatgatt
     8761 gaaaaaatat catcgctata ttcttccaaa agataatttt tcacaagact tgttgtccct
     8821 ggattagcaa gaatccagag catattatct ttgatttttg ttcccgtaat tgcatcaaaa
     8881 gctaaggctt tatgaaggct tgactgtaaa acttccttgt tttttggtaa atcataacga
     8941 taaccaccag attcagctgg caccttgatt agggcaagtg atttaatatc gcgggaaacg
     9001 gtcgcttgag taacgtcaat tccatgagtt aagagggtat tcacaagttc ttcttgcgtt
     9061 ttaatttcgt tttcacggat aaattgagca ataaagttta atcggtcttc tcttttcata
     9121 gttcttcact ttctttttgt aaaactgatt caatattaac ctgctgagca atttctgctt
     9181 ttccatcttt aagtaaatgg acaagaaatt caacgtttcc agccccaccc ttgattggcg
     9241 aaaaggtcaa accttttact gaaaaaccaa gttgagtggc tgtttttaaa actttttcaa
     9301 tagtcatttg gtgaactttg gggtcacgaa taattccatt ttttccgact tgttcacgtc
     9361 ccgcttcaaa ctgcggttta ataagagctg ctacttcgcc attttcttcc aaaatttcat
     9421 aaagtggcgg tagaattaaa tctaaagaaa taaaactaac atctatacta gtaaatgacg
     9481 gtcttccttg ttcaaagtca gctaaaacag catttcggaa attaaattgt tccataacga
     9541 caacgcgttc atctgagcga attttccaag ccaattgatt ggttccaaca tctaaagcat
     9601 agactaattt ggcaccattt tgaagcatta catcagtaaa accaccagtt gaagaaccaa
     9661 tatcaagaca agtttttcca ttaatttcta aatggaattc tttaagagcc ttttctaatt
     9721 ttaaccctcc tcgactaaca tatcttaact tttcaccttt aagacgaagt tctgttccat
     9781 catcaatttt ctgaccaggt ttatcgtaac gctctcctga tttactatca acaactagac
     9841 cagccattac tcctcttttg gcctgctctc gtgtttcaaa caaaccttga ttcgtggcaa
     9901 gtacgtcaat tctttctttc atgtagatct ttctttatag taattatacg tatttttctt
     9961 agaaatgtaa ctaataattt ctttttatat ttctattttt ttatttcact tccaattgct
    10021 caataatttt aaaaatttca gagctgtcag taactgataa gtctgtcagt aattttttaa
    10081 cttctgacaa atttcctgtc agtgattttt ttgcttcctc aagtcctaaa tgagcaacat
    10141 atgttgattt ctcctctaaa atatccttac ctggtgtttt tccaagctca gcaaaagttg
    10201 ctgtgacatc taaaatatca tctcgaattt gaaaagccaa tcctaatatt tgccccactt
    10261 gacgaagttt ttcaacttca tcagttgatt tttgagcaac aattccagca gctacaaaag
    10321 gaaaagttaa aagtcgccca gttttcaagc gatgaatctg ctcaatttca gctaatgtca
    10381 actcttttcc ttcaccagcc atatccaaga tttgacccgc aaccattcca taagaacctg
    10441 aagcaaaggc caattcacgc gtcaacgcta ctattatttc tgcggataaa tcagcagttg
    10501 aaaggataaa gaaagggtca aaaaataaag tatcaccagc taaaattgca gttgcctcgt
    10561 caaatttctt gtgattagtt aactgccctc gacgataatc atcattatcc attgctggta
    10621 agtcatcatg gattaaagaa cccgtatgaa tcatctcaag tgcggctgcc acatgataat
    10681 gagccttact caattctaaa tcaaaagcct ctaataggtt taaaaaaagg agagggcgaa
    10741 ttcgtttacc gcctgccaat aaagaatatt ttgctgattc ggctaagcca gttggaaatt
    10801 cagcgctttc ataaaattca gttaaaaagt cttctaactt tagtatcttc gtatccatta
    10861 ccctaattat accaaaattc acggctaaaa accgtgatga tttgaggaaa tttttttatt
    10921 ttttaaatcc attccatttt tataagtgag ccttttgctc attcattgct aatactcttg
    10981 taatattttc actcgttcgc tcaacgttct ttgcgccgtc agccaaggca tctgacaaag
    11041 attgtgcttg actcaaaaca ccaaaaatag cggtcattcc ttcgtcataa agaacatctg
    11101 ctccatcccc aatatatcct gccaaagcaa agcaaggttt cttgtatttt ttagcaattt
    11161 tacagacgcc atagggtgct ttaccaaatt ttgtctgata atccattcca ccttcacctg
    11221 taaatacata atcagcttct ttaattttat cttctaagta tattgtttgt gcaacaagct
    11281 caattcctaa ttgcattttt gcattggtaa aagcaagcaa acctgctccc aaaccacctg
    11341 ctgcaccagc tcccggttta tttttaatat ctttccccag atcattatga acaatttctg
    11401 cataatgctt caagttttca tccaatactt tgaccatttc ctcagttgct cccttttgtg
    11461 gtccaaaaac ataagaagcg ccattatttc cggttaaagg attggtgaca tcagtagcaa
    11521 ttaatatttc aatttcttcc actcttgggt caaaatcact catatcaatt gttctaactt
    11581 ctttaaggaa acctccacca agtggaatct cttcttggtc tttatttaaa aatttagctc
    11641 ccaaagcacg agccattcca gagccaccgt cattagtcgc acttccacca atgccaatga
    11701 ttattttatc tactccttca tccattgcag ccttaattaa ttgtcctgtt ccataggttg
    11761 atgtaatcaa tggatttcta tcttccaaag caaccaattc cagaccattt gcctttgcca
    11821 tctcaatgac cgccgtattt gagtttccca aaataccaaa ataggcctct acatttgtat
    11881 ttgcaaatga accttgtact tttttatata cccttcgtcc acccgttgca tcaatcaaag
    11941 catctgttgt tccctcacca ccatcagcca ttggcataga aattatttca gccttaggaa
    12001 atactttttt aattcctttt tccattgctt gacaaacttc cagcgcactc aaactttctt
    12061 tgaaagaatc tggcgctaat acaaattttt tcttcattta atctactctt tctataaaag
    12121 acttgaccat aactctatct attattagta tataataaat aagattgata ttagaataat
    12181 aggctttttt gtcagtaaaa ttttgtttaa aataaaaaac cttgaaaaat caaaggtttt
    12241 ttattttagt agtctttctg ttccggagag aaatcactct cctgatcatt ttttccaact
    12301 atttttacta atgtttcttc cgcttcattg agtgtttttt tcaaagtttc cgaaattttc
    12361 attccttttt gaaattcagc aatagcatct tccaacgcta catcaccaga ttccaactta
    12421 cgaacaatat tttctaactc tgccaaatta tcttcaaatt ttacatcttc ttttttggtt
    12481 gccattattt tacctccact attacttttc cgtcagtcaa ttcaacatct aaagtctgac
    12541 cttttttcac atcacttaca gatttaataa tctttccctt ttcgtcagta acgagggaaa
    12601 aaccacgcgc ttttattttc gagatatcta ataaaagtaa agactgataa agttgctccg
    12661 tcttattctt tttagcttca actatctttc cgtaagtcgg aattaatttc ccagctgaca
    12721 gctcaaaacg gtgtttcata tttgcaactt tattttccgt cagcactgac aaacgttcac
    12781 acagacggtc aagtttttgt aagtgtccat cgtacaagcg ttctggctgt ctaaaaacga
    12841 ctgactggct taatttatct actcgttcac gccttatttt tattaaatgt gttaagcggt
    12901 taaaaagtcg tttttcctgc tcattcgccc aatttatcaa atcaaccttc gtatttggtg
    12961 ttgctaattc ggctgccgct gttggagtcg ctgcacgact atcagcaaca aaatcagcta
    13021 aagtcacatc tgtttcatgt ccaaccgatg aaataattgg aatacgtgat tcaaaaattg
    13081 ctcgaaccac aatttcttca ttaaatcccc ataaatcttc gatagaccca ccaccacgac
    13141 caataatcat gacatcaaaa tcaccacgtt gattagctcg acggatattt ccagcaattt
    13201 cttcagccga accttgtcct tgaacttttg tcggataaag aacgatttga ctcatcggaa
    13261 aacgacgttg aaccgtcgta ataatatctc gaatgaccgc tcctgacggg ctagttacca
    13321 cagctatttt tttagaaaat tgtggcaaag tttgtttcca acgttgttca aatagccctt
    13381 cagcagtcag ctttttcttc aactgttcaa acttaaccgc aagagctcca acgccatctg
    13441 gaactaaact ttcaatattt atagaataag agccagaagg tggataaata ctgattcgac
    13501 caacagccaa aactttcatc ccttcttcta attcaaagtc taatttgcga aattgtcccg
    13561 cccacatcgt agcttgaatc acagcgccct catctttaag tgcaaaatat tgatgatttg
    13621 gtcttcttct aaaatttgaa atttctcctg tcaaataaac ccgttcaaga tatggatcac
    13681 ggtcaaattt cgcttttaaa tattttgtta aggttgatac tgataaatat tctgtcattc
    13741 cctcactctt tagttctcaa ttaatctttt tactaatcat tctgttagta aaatttctac
    13801 tgctaaaatc gaaaaaaagt aaaaagttta tcttcaaaaa acttctaact taaaaataag
    13861 tccttagaaa ttactataaa cttagttact cttttattaa ttaactattt attttcattc
    13921 atttttctac ttgctgcacg aactgtctgt tccataagca ttgtaatcgt catcggacca
    13981 actccaccag gaacgggggt aatcaaactt gcaacatctt ttacttcatc aaaatcaaca
    14041 tcgccatgaa gttttccatc ttcatcacgg ttcatcccaa catcaattac aactgcccct
    14101 tttttgacat cctcagcttt aatcatccgg tcacggccaa tagcaaccac caaaatatca
    14161 gcttccttag tcaattcgcg caagttttct gtttttgaat gagcaatcgt cacagtagca
    14221 tcagccatca ttaataattg cgccattggt tttccgacga tatttgaacg accaatcaca
    14281 actgcacgtt taccagaaag ttctacatta tattcacgga acatttccat aataccggct
    14341 ggagttgagg gaatcatcaa aggattccca gaccacaaac gtcccatatt cattgggtga
    14401 aaaccatcca catctttttc tggatcaata gctagtaaaa ccttttcttc agaaatatgt
    14461 tctggcaatg gcaattgtac caaaatacca tgccattgtt ctgactgatt atactgttca
    14521 attaaatcta acagttcttg ttctgacaca gtttctggta gacgaaccac actagaattt
    14581 aaaccaattg ctgtggcttg tcgtgcttta tttcggacat aaatttgact cgcaggatct
    14641 tcgcccacaa gaataacggc aagacctgga acattgtccg cttcttttaa tttatcgact
    14701 ttaactttca actcagcttg cattttagca gcaagtgctt ttccatctat caagttcata
    14761 gaactattat accataagct aacattcatc ctctaatcat catcattcct ttttctttct
    14821 ttattttaaa ttgttcgtaa tttttaataa aggaataatt ccaaattaaa aagaaacttc
    14881 tttccaaaga aaagaagtcc ttaattaaaa tatactactc aaaacctttt tttatattta
    14941 acttttccaa tagttaacgt tgccactaat cccaatccca attctgctaa tactaaactt
    15001 aaatcatcat cagcacctgt tttgggaagt tcttctttcg ttacagttgg tacaagttgt
    15061 aagctcgttg cgcttaatga atttgaaaga ctcggactac ttgatacctt agaaattaaa
    15121 gtcgaaactt ttgattcatt cgaaggtaaa tttgagtcac tcaagttatt tagtttcatt
    15181 tctgaagtat acgaactatt tgaagttaga cttgagccat ttttatcatt agattgtaaa
    15241 tttggattag tcaacatact tgaagatgtt gttaaaccac ttgactcaga tgaagtcaaa
    15301 cttgcactac ttgattcatt tgaactcaga ctcgaatgac ttgaattttc agaagatgaa
    15361 cttgtagtac tagtttgacc agtgtttgaa tttgaatcac ttgtcccacc agaacttgtc
    15421 atactacttt cgcttgaact taagcttgaa gcacttgaac cttctgagct tgaacttgag
    15481 ccatttactc cagctgaact tgactgactc gagtctaccg aagatgaact ggcaacacta
    15541 ctttcactgg aatttgaact tnnnnnnnnn ncttacccca gtagaacttg actgacttga
    15601 gcccacagaa gatgaactgg caatactact ttcgctggaa tttgaacttg aagcactcga
    15661 accctctgag cttgaacttg agccatttac tccagctgaa cttgactgac ttgagtctac
    15721 cgaagatgaa ctagcaatac tactttcact ggaatttgaa ctcgaaatgc ttgaacttga
    15781 gccatttacc ccggctgaac tcgattgact tgagtctacc gaggatgaac ttgtggcact
    15841 accttcactg gaatttgaac ttgaagcact tgaaccctct gagcttgagc ttgaacttga
    15901 agcattagaa gtcgaacttg aagtatttgc ttcactagaa ttagaactcg tgttgcttga
    15961 tacatttgaa gatgaagttg aactactagc tgcacttgat gaagaactgg cactactgct
    16021 tgattggcta ctattagcac tagaatttgg attaactgtt gaagcaccaa cacttggagt
    16081 taaagaattg ataattgtcg ttattccatt aagtgcatta ttaacgaaat tattaatatt
    16141 attttgtatt tgactaatag tgttcgaaag accattttcg atagctccaa gacctggtaa
    16201 attatttaca atccccgtcg cactttcaac aatattattg atcgcatttt gcaattgatt
    16261 gagcacttgg ttaagaatat ccgaagcacc agcaggaaga ttaccaaatg agtttagact
    16321 attttggagc gtgttctcaa tcgtggctaa ggctgttgaa ccaaggcttg taagattacc
    16381 caaactatta tttacttggt caagaaggct ggaaactccc gttaaattcg caacttctcc
    16441 caaagatgct ccagtaagat tatttaatat tgggcttaaa acattattaa ctgtagtacc
    16501 tacaagtgga atattactaa tagttggaga taattgactc caagcaattt gacctactcg
    16561 attaatcgct gaattaacta ctaaaccagc caagtagttg acaagatcat ttccttgaag
    16621 agagacaagt gtgtctaaat caaaattaac accacccaag gcattggaag ttgtcgtatt
    16681 aagttgatta acaatcccac ttgttacagt acttattgcg ctaagtactg ggcttagtac
    16741 tagacttgcc cccggaatac ttgaaagtcc tggaattgtt ggattttcaa gaaaagtaag
    16801 catagcagca gggctcattg atgggatagc attaaatgcc gccgcaattt gccctccaac
    16861 taatggaatt tggctaacat ctaaacctgc agattttatt tcatttaata gaaaggctcc
    16921 aggattagca gctgcttcct gaatatttcc aacaatattg acgatttgtt caacaccatt
    16981 aagagctgca gcggctgtag tcattcctgg aatattaaaa gttccaagag tgctaaaaat
    17041 atttgctaaa ccactaattc ccactgtcga aattgcttga tttacaagat ctccaagtgt
    17101 tgtgttaaga atagctgaac cacttgttgt agcaggcgct gctgcagcca gtgcctgagt
    17161 aagcattggc accatggacg gattagtcgc tagaatagct gtaaaagaag cgacagcagc
    17221 actcgaagca ctagcactac tatttcccac aagattcatt tccgaacttt gagaaactga
    17281 tgcaatacca ctatcaattg ctgaactttc actcaaaact cctgatgaac ttgttgaact
    17341 ttgagaccca actgccgaat caacactgtc tgcagcatta gaagaactta atatagaatt
    17401 gctgccatta tcatttgatg agcttgaatc tgcaagcgat acgatattgt ttgtaggagt
    17461 ttgaataacc accgtacttg tcgtattttg gctttcatta attgagtagc tactatctga
    17521 cacatttgaa gttattccct cagtatcagt ttctactgtg ttagccagtg atttattaga
    17581 actttggtca ctagcttgtt cgtaagcaac ttgattttga ctagcagcta catcactatt
    17641 tgtcgatgaa gctagtgctg aataacttgt tacctcagta ataccactaa tttgctgact
    17701 actatcaatt gctgtgtccg cttttacatt ttggtcagta atcgttcctg aaacgataat
    17761 tatagctaat gctgaagtag caaataacca acttttccct gatttccaag ttcgaaaatg
    17821 agacttggag gtaacagtag tcacttctgg ccgtattttt ttcatttatt ctctccttgc
    17881 cgatactttt ttattggtat cgctatgaat atatattata ttataatatc acttttaagt
    17941 cacaaaagaa accttttagt tattattttg taatatttat agaatacagc ttttttcctt
    18001 gactttgata gtttacaatt gtaaactata tatagataga aatttcaaag cattcattta
    18061 ggaggaaaat atgtcaaata aaactcattc gtctaatcac gatgaaatga tgtctgagca
    18121 tcatcataat catgaaataa tggatatgga gcacgaaaac catgagatgc acaacatgca
    18181 caatatggat aatatgcatg atatggacaa tatggatatg atgaatcatg gaggacacat
    18241 gatgcatatg ggtgatatga gtaaaaagct caaagtggct atcattctta tgattccgct
    18301 actactaatt tcaccaatcg ctggctttac tatccttaaa ttccccggaa gtgaaatttt
    18361 gcaacttatc cttggtacaa ttatcttctt ttactctggg actccttttt ttagcggagc
    18421 aaaaggtgaa ttaaaaagcc gtaagccagc catgatgatg ctgattacaa tgggaattac
    18481 cgttgcctat gcttattctg tttatgccac aatcatgagt cttaacggac atatgggcat
    18541 gaacttctgg tttgaactgg caacattaat tgtcattatg ttgattggtc acctgattga
    18601 gatgaaagca atcatgggtg ctggcgatgc attgaaagat ttagcaagcc ttgttcccaa
    18661 aaaagctcac ttaaaaagtg ggaaggatgt ggagctttca gaactaaaag ttggcgattt
    18721 acttttagtg aaagaaaatg agaaaatacc tgcagatggc cttatattaa gtcaagcgct
    18781 cgttgatgag tcaatgatta ctggtgaaag ccgagcagtc aataaaaaaa caaatgacct
    18841 tgtttatggt ggttccctca atcaaaacca accatttgag atgaaagtca caacccttgg
    18901 aaaagattca tttctcaatc aagtggccga attagtcaag aaagcccaag ctcaaaaatc
    18961 taatttggaa aatatggcag atagagtggc tggttacctt ttctatgccg cacttattgt
    19021 tggtatcttc tcattagttt tttggacaat tagttctaac tttagttttg ctctacttct
    19081 tgcagtttct gtttttgtaa ttgcatgtcc acacgcttta ggtcttgcgg ttccacttgt
    19141 tgtttctcgc ctaaccagta tttctgctaa aaatggttta ttaattcaaa acagaacttc
    19201 tctagaaaaa ataaatacaa ttaaatatgc cttaatggat aaaacgggaa cattaactga
    19261 cggtaagttt attgttcgta atgttattga ttttactgat gaaacagaca ttctccaaat
    19321 cgtggcagca cttgaaggaa gttccaccca cccgattgct caatcaatcg tttcagctgc
    19381 taaacctctt gaaaatctaa aagttgaagc ggttgaaaat attccaggag ttgggattaa
    19441 agggcaagtt aatcaaaact tttatcaaat tgttaactat aaatatcttc gtgaaaatca
    19501 actttcttat gatgaaaaaa agattgctca atatttagat ttaggtttaa ctgtatcttt
    19561 cctaatcaat gaacaacaag atgttttagg atttattgcc ttaggagatt ctcctaaagc
    19621 agacgcgaaa gcctttatta atggtttatt agcccaagga attacccctg ttatgctcac
    19681 gggtgataat aaagaaactg ctcaaaaaat tgctagtgca ctaaatattc ccgaatttag
    19741 agcggaatta aaacctgaag ataaagcaga aattgtgaaa gagtaccaaa agaaagccgg
    19801 cgtgcttttc attggtgatg gtgtcaatga ttccccagct cttgcaactg ctacaattgg
    19861 ttttgcgatt ggagcaggaa cttcggttgc tatcagtacc gctgatgtcg tcctagttaa
    19921 ctccaatcca agtgacgtct tggatatgat taatatctcc aaacgcatgc ttagaaaaat
    19981 gaaacaaaac ctctggtttg gagcaggcta taacattatt gctattcctg ttgcagcggg
    20041 tattctttat ccatttacag ggatttatat tgaccctctc attgcagcag tcctgatgtc
    20101 aatctcaacc gtgattgtct caatcaacgc gatgggattg aggtatgata aaaaatagaa
    20161 gagcctatgc tcttctattt ttttatatta ttatttagtt aaaaaaatta ttttatattc
    20221 tttcttctat tgccaacaac atcaggatag agctttcgta attttcttgt tcccaatagt
    20281 gcagatacaa gggctagaac ttgcaaaata actgtcacga atcctactaa taatcctatc
    20341 tctaactcta aaagattatg tgcctgattg gctaaaatga ttaagacagc accaatcacg
    20401 ctcaaaacat tgagactata tactaaaatt gaagcaatac tttttattct taatttatga
    20461 ttctgaacat gaagagcgat agcataaatc aggataagta aaccaaatcc ccaaactaga
    20521 tatgagtctg ttattatttt tgcaacttgt agtaaaaaac tgatgaatac agcgataatc
    20581 cagattccta acaaaccatt gtatttataa gctttttgaa tcacttcttt ttctttattt
    20641 tcgtcaatct cttctttcat ttttcaattt cctgttcttt ttttaattcc atgagagcta
    20701 aagttctaaa ttttcttgcc ctcctgatgt aaatccagta gatatacaca agtaaattca
    20761 caagaattaa atcagtaata tagattaacc aaattcctac atcacctgag tcgatgtaaa
    20821 gaccggctaa cgttatcccc acacttccac aaatcata
//
