LOCUS       NZ_JAQEAZ010000003     21713 bp    DNA     linear   CON 29-FEB-2024
DEFINITION  Blautia hansenii strain AM27-24LB AM27-24LB.Scaf3, whole genome
            shotgun sequence.
ACCESSION   NZ_JAQEAZ010000003
VERSION     NZ_JAQEAZ010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Blautia hansenii
  ORGANISM  Blautia hansenii
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Blautia.
REFERENCE   1  (bases 1 to 241667)
  AUTHORS   Lin,X., Hu,T., Chen,J., Liang,H., Zhou,J., Wu,Z., Ye,C., Jin,X.,
            Xu,X., Zhang,W., Jing,X., Yang,T., Wang,J., Yang,H., Kristiansen,K.,
            Xiao,L. and Zou,Y.
  TITLE     The genomic landscape of reference genomes of cultivated human gut
            bacteria
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 241667)
  AUTHORS   Zou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-2022) BGI Reaserch, BGI-Shenzhen, Beishan
            Industrial Zone, Shenzhen 518083, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: MGI
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/29/2024 10:24:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,933
            CDSs (total)                      :: 2,870
            Genes (coding)                    :: 2,807
            CDSs (with protein)               :: 2,807
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 15 of 64
            Pseudo Genes (incomplete)         :: 49 of 64
            Pseudo Genes (internal stop)      :: 7 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:43:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 78754
            Orig. end                         :: 100467
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAQEAZ010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21713
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21713
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21713
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11713](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11713
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            517..1119
                     /locus_tag="PGT18_RS05120"
     CDS             517..1119
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009246767.1"
                     /locus_tag="PGT18_RS05120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YdcF family protein"
                     /protein_id="WP_009246767.1"
                     /transl_table=11
                     /translation="MNDKFLNQITEFIFVEDKAEKSDMIFIPGSGFPQLAEEAAKLYHQ
                     GLAPYILPSGKYSILNGKFAGVQEKQELYDGEYETEWEFLKEVLKKNQVSEEHILREDK
                     ATYTYENAIYSRKVTDCLGMEIKKAILCCKPYHARRSLLYYQLLYPETQFFVRPIQDSD
                     VKRENWYLTEKGIRLVFGEVQKIGEQFEDITKEMSME"
     gene            1315..1899
                     /locus_tag="PGT18_RS05125"
     CDS             1315..1899
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223018.1"
                     /locus_tag="PGT18_RS05125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_004223018.1"
                     /transl_table=11
                     /translation="MKITKIILTTIMIVVAALGLFRILPFNITNSIMFTSLATLLLLRS
                     IEWKKSRDKTGFLFTFIAAVFIYIVVIFNICSSLLGYEKVDNRDCLKDINPSEIVEIKC
                     SGTTGGKDGHFEYFLDERQQEDFVELLGKVKLGRKAEREETLSSGAVTYYTLEFEDGEV
                     LEVSPGRFFMVNDDYYYFLNYDKIWDEFLEL"
     gene            complement(1961..2713)
                     /gene="pflA"
                     /locus_tag="PGT18_RS05130"
     CDS             complement(1961..2713)
                     /EC_number="1.97.1.4"
                     /GO_function="GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223016.1"
                     /locus_tag="PGT18_RS05130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate formate-lyase-activating protein"
                     /protein_id="WP_004223016.1"
                     /sec_met_domain="QueE (E-value: 6.7e-15, bitscore: 48.8,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-27, bitscore: 90.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.1e-33, bitscore:
                     107.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTECKTGFVHSIETFGTVDGPGIRLVVFLQGCPMRCLYCHNPDTW
                     APKKGQSMTVEEILEIYEKNKGFYQNGGITVTGGEPLMQLEFVTALFQAAKSKNIHTCL
                     DTSGILYREKQAEAYQKLFSYTDLILLDIKHSASEEHKKLTGHPLSPVLDFLKASETAR
                     VPVVVRHVIVKGFTNSKEELDGIGKLLASHKNIKGLEVLPYHNMGEQKYSELNMEYPLK
                     GMENLPKEEAQKARSYILESYKKYRVRK"
     gene            complement(2700..2942)
                     /gene="grcA3"
                     /locus_tag="PGT18_RS05135"
     CDS             complement(2700..2942)
                     /codon_start=1
                     /gene="grcA3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009462180.1"
                     /locus_tag="PGT18_RS05135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="autonomous glycyl radical cofactor GrcA3"
                     /protein_id="WP_004223014.1"
                     /transl_table=11
                     /translation="MNISNAQIDNLVNLLDGYAEKGGHHLNVNVFTKETLLDAQKHPEK
                     YPQLTVRVSGYAVNFHKLTKEQQDEVISRTFHDGM"
     gene            complement(2967..5042)
                     /gene="pflB"
                     /locus_tag="PGT18_RS05140"
     CDS             complement(2967..5042)
                     /EC_number="2.3.1.54"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008861 - formate C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006113 - fermentation [Evidence IEA]"
                     /GO_process="GO:0015942 - formate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223010.1"
                     /locus_tag="PGT18_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="formate C-acetyltransferase"
                     /protein_id="WP_270387503.1"
                     /transl_table=11
                     /translation="MREEWISFNKGNWTKEIDVRDFIQKNYTPYDGDDAFLAGPTKATQ
                     TLWEQVMELTKQEQEKGGVLDMDTKIISTITSHGPGYLDKDLETIVGFQTDKPFKRSLQ
                     PYGGIRMAMKACEDNGYHVDPEVVEFFTKHRKTHNDGVFDAYTPEMRACRSSHIITGLP
                     DAYGRGRIIGDYRRVALYGVDRLIEDKENEKNTTRTTMYSDVTREREELSEQIRALKEL
                     KELGKIYGFDISRPAANVQEAIQWLYLGYLAAIKEQNGAAMSLGRTSTFLDIYAERDLK
                     NNTFTEEQIQEFIDHFIMKLRLVKFARTPEYNALFSGDPTWVTESIAGMGIDGRHLVTK
                     MSFRYLHTLENLGTSPEPNLTVLWSTKLPANFKRFCAKTSIASSSIQYENDDLMRVTHG
                     DDYAIACCVSSMRIGKEMQFFGARANLAKCLLYAINGGVDEVSKKQVGPKFRPITSEYL
                     DYDEVMDRFQDMMKWLAGVYVNTLNVIHYMHDKYSYERLQMALHDKKVTRWFATGIAGL
                     SVVADSLSAIKYAQVKTIRDENGIAVNYEIEGDFPKYGNDDDRVDDIAYDIVHTFMEYI
                     KGNHTYRGGIPTTSILTITSNVVYGKATGSTPDGRKAGQAFAPGANPMHHRDSHGAVAS
                     LNSVSKLPFKDAQDGISNTFSIIPGALGKDDAVFFNDIAFELEPDCACCEPNIDLQ"
     misc_feature    complement(5055..5069)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.59"
                     /tool="antismash"
     gene            complement(5260..5928)
                     /locus_tag="PGT18_RS05145"
     CDS             complement(5260..5928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018594931.1"
                     /locus_tag="PGT18_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF624 domain-containing protein"
                     /protein_id="WP_009246766.1"
                     /transl_table=11
                     /translation="MSSLFNMDSPIMRFLSRVCDIMILNILCIVFCIPIITAGASVTAM
                     YTVTLKMVRGEESYIFKGFLKAFKENFKQSTIIWLIMAAIGIFIYVDYRATAFLPGNMS
                     TIFQILIGALGILYFMILVYVFPYTARFINNIKNIFKNSLLIAILNLPWTILLMLIPLG
                     LGFLTFLTASTLVYGSMLWLLLGFASVAYVCSIILRKVFEKYEPHEEEEENELPEISEK
                     "
     gene            complement(5955..7229)
                     /locus_tag="PGT18_RS05150"
     CDS             complement(5955..7229)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006442972.1"
                     /locus_tag="PGT18_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemolysin family protein"
                     /protein_id="WP_009246765.1"
                     /transl_table=11
                     /translation="MDSSDAIQFLILIILICLSAFFSSAETSMTTVNKIRIQALADQGD
                     KRALTLLNVIEDSGKLLSTILIGNNIVNISASSLATTLTMRLFGSAAVSISTGIITLLV
                     LIFGEITPKTLATVHSEKMALSYAKVIRILMFILTPIIFIINKLAQGVLTLMRIDANAK
                     CNTITEHELRTLVNVGHEEGVIESEERQMIYNVFDFGDSQAEDVMIPRIDVTFADVNSS
                     YEDLVGLFRDEKHTRFPVFEDTTDNIIGIVNVKDLLLTSKEDFSVRKILREAYFTYEYK
                     RTSELLMEMKENSVTFAVVLDEYGATSGIVTLEDLIEEIVGDIHDEYDSEEEELREIIP
                     NREYIALGSARLDDLDETLHLNIVSDDYDSIGGYIIEQLDRFPAAGESVTTDGGVKLVV
                     DKAERNRIETVHIYLPEKTEENFDE"
     misc_feature    7254..7274
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.82"
                     /tool="antismash"
     gene            7441..9483
                     /locus_tag="PGT18_RS05155"
     CDS             7441..9483
                     /GO_component="GO:0009986 - cell surface [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004223001.1"
                     /locus_tag="PGT18_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_270387505.1"
                     /transl_table=11
                     /translation="MNRNKKNLHKVAANVLGVTLASALVTGAVAETAAPIAVFAAQQEA
                     QTQEKIIYLNGSIQAGENADGTGQAQAVDSFEKAFALAGGQGTVMVCGMVNVSTEKKLH
                     IPAGVKIKRNAGFTGALVKVTGKGKLTVTGDGITAQDVDVSTAESGKGAFVAAKIPQVV
                     MPAQITLNNLAEWNTCSFPLLGFTGEGAFTWGTQVPPSSYETEMKVVFTPKDTENYDYS
                     QVSGWDNQSKTVTRTIKVFIEALKPQVEEPAKPMAEVQIPSELKFATKEEFKNLDFANA
                     GFKGEGVFAWEAQTEPSSYETKMNVVFTPSDIEKYDYTQTAGWNGESKKIVREVKVFIE
                     ELKENTTEPETPQPEVPETEVPETEKPETETPETTPPTEPENPDTQEPEVPQTEAPEAE
                     VPETEKPENGGVEIEYVNPDEVVQPEEETQPEVTYQAEAGQNGEIAQEAPEALPVGSLI
                     DETGVQVSGDFIPYYVDLQVTYNEAVNELPDAGIGEILSAYELKLWDLKEDKEYQIPEG
                     RKVKVLIPLPENANCFSDLSIAHYLGNNRYEYFVFSKDGKTGNMTVEEKDGAEYLAFET
                     ASFSPFNVGGHQIVGPGVNSDNHKPSTGTSQSTTQTKPNTSASNSSAQSTVKPNTQKKP
                     AQNNTTPVVQIVKTGDESKTVFYVLIGFGALIIAGLAVFFGKKKK"
     gene            9540..9914
                     /locus_tag="PGT18_RS05160"
     CDS             9540..9914
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009246764.1"
                     /locus_tag="PGT18_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_117466859.1"
                     /transl_table=11
                     /translation="MEKRVSKNAKPMLMIKALLLAYAATGILLLILAFLLYKMGLGESQ
                     INIGIMVTYIVSCLFGGFYMGKKIKVRRFAWGMGVGTGYAVLLMAVTFLTVHQISGDFK
                     EMLMMFFLCFFGGTLGGILA"
     misc_feature    complement(9923..9939)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            10001..10141
                     /gene="scfA"
                     /locus_tag="PGT18_RS05165"
     CDS             10001..10141
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015524633.1"
                     /locus_tag="PGT18_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_004222992.1"
                     /sec_met_domain="TIGR03973 (E-value: 8.3e-27, bitscore:
                     86.6, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.1e-26, bitscore: 86.2,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKSLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEH
                     K"
     aSDomain        10343..10639
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_PGT18_RS05170_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="3.00E-35"
                     /identifier="RREFam024.1"
                     /label="PGT18_RS05170"
                     /locus_tag="PGT18_RS05170"
                     /protein_end="99"
                     /protein_start="0"
                     /score="111.4"
                     /tool="antismash"
                     /translation="MIHRYKNNGYNIVLDVNSGSVHVVDELVYDVIGLLDEGQEEAVVY
                     EKLKDTYKKDDIQTALKEIQELKDAEMLFTEDIYRNAIEHFKERETVVKALCLH"
     gene            10343..11713
                     /gene="scfB"
                     /locus_tag="PGT18_RS05170"
     CDS             10343..11713
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009246763.1"
                     /locus_tag="PGT18_RS05170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_009246763.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 2.2e-34,
                     bitscore: 111.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2.3e-76, bitscore:
                     250.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.2e-15, bitscore: 50.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.5e-14, bitscore: 47.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.8e-18, bitscore:
                     59.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHRYKNNGYNIVLDVNSGSVHVVDELVYDVIGLLDEGQEEAVVY
                     EKLKDTYKKDDIQTALKEIQELKDAEMLFTEDIYRNAIEHFKERETVVKALCLHIAHDC
                     NLACRYCFAEEGEYHGRRALMSYEVGKQALDFLIANSGNRKNLEVDFFGGEPLMNWQVV
                     KDLVAYGREQEKIHNKNFRFTLTTNGVLLDDEIMEFANKEMANVVLSIDGRKEVHDFMR
                     PFRKGAGSYDLVVPKFQKFAKSRGEKSYYARGTFTRHNLDFSEDVLHLADLGFDQISVE
                     PVVADEKEEYALKWEDVPKICEEYDKLAKEMIKRKKEGKGFNFFHFMIDLTGGPCVYKR
                     LSGCGSGTEYLAVTPWGDLYPCHQFVGEEKYLMGNVWDGVKRTDLCKEFKNCNVYAKEK
                     CQNCFAKFYCSGGCAANSYNFHGSINDVYELGCELQRKRVECAIMLKAAEAAEEQEN"
     gene            11732..13969
                     /gene="secD"
                     /locus_tag="PGT18_RS05175"
     CDS             11732..13969
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009246762.1"
                     /locus_tag="PGT18_RS05175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_270387511.1"
                     /transl_table=11
                     /translation="MKKNRGILVLVLTAIITGFLIFTTAVGFGPTGTGAAKNIKTGLDL
                     SGGVSITYEASKESPTEDEMADTIYKLQKRVENYSTEAQVYKEGENRIIVEIPGAKDAN
                     KILEELGKPGSLYFIKHKDSAGGENYTLNTETGEYELAKTIEEIEADGGIVLTGTDIKD
                     AKAAVAQDDLKNNVNVVSLSFTKEGTDKFAAATKEAVEAGNDTIGIYYDGTFVSVPSVR
                     QEIKDGQAQIDGMKDAAEAENLASTIRIGGLKLELSELRSSVVAAQLGEKAISTSLVAA
                     AIGLALIILFMIFVYRIPGLVSGIALIIYVCLDLIALNAFDLTLTLQGIAGIILSIGMA
                     VDANVIIYARIQEEIASGKSVRTALQNGFKKAFSAIFDGNITTLIAAFVLNWLGSGTVK
                     GFAQTLALGIVLSMFTALVVSKYLMYAVYAVGVRNEKFYGKRKERKPIPFLQKRKVFFA
                     VSLILILCAPVSMLIFKGTTGESLKYSLEFKGGTSTNVEFDKDMSIAEIDEKLTPLVEE
                     VTGDKNVQATKVVGNNQVIIKTRTLNVEQREKLETALIDNFGVAQEDITSESISSTVSN
                     EMRADAVKAVIVATVLMLLYIWFRFKDIRFASSAVIALLHDVLVVLAFYAVARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLASAGKKTDLETLVNASITQTLTRSIYTSLTTF
                     IMVFLLFIMGVSSIREFALPLMVGIVCGGYSSVCITGALWYVMKKKFKKQN"
     misc_feature    complement(13988..14003)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     gene            14033..15748
                     /gene="recJ"
                     /locus_tag="PGT18_RS05180"
     CDS             14033..15748
                     /GO_function="GO:0008297 - single-stranded DNA
                     exodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004222988.1"
                     /locus_tag="PGT18_RS05180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="WP_270387514.1"
                     /transl_table=11
                     /translation="MEKWVVAAKKADFQGISNRFGVDPVIARLIRNREQITDEEIDTYL
                     HGELRNLHPWKALKGIDELLNILIEKIQQKKKIRIIGDYDIDGVCSTYILFQGLKKANA
                     LADVDIPDRMKDGYGISKELIERAYEKEIDTIITCDNGISAIEQIAYAKEKNMTVLVTD
                     HHEIPYEEKEDGSIERFLPNADAIVNPKQEGCTYPFKEICGAMVAFKVVWGLFEKRNIP
                     LSEIEELIPIAAIATVGDVMDLVDENRILVKEGLKRIQNTNNEGLKALIRVNNLENREI
                     TAYHIGFVLGPCINASGRLSTAKRALELLLSKDTKEASVLAEDLKELNDSRKDMTVKGV
                     ERAVEIIENTELKNDRVLVVYLPECHESLAGIIAGRIRERYTKPVFVLTKGEEGVKGSG
                     RSIEAYHMFQEMVKCRELLTKFGGHPMAAGLSMEEENIEKFRRKLNENCTLTEEDMVEK
                     IVIDVPMPMSYVTIPLIRQLGQLEPFGKGNTKPIFAQKDIRFSNCKVFGKNRNVVKMKA
                     QDSFGFGAECIWFGDGDEFLERLKEKDVWDVIYYPSVNSFQGRESIEMIIQNIR"
     gene            15859..16398
                     /locus_tag="PGT18_RS05185"
     CDS             15859..16398
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004222987.1"
                     /locus_tag="PGT18_RS05185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_004222987.1"
                     /transl_table=11
                     /translation="MEDCKKKKIEDYVRSIPDFPQEGIIFRDVTSILEDADGFALAVDS
                     MQKLLEGVDVDVIVGTESRGFIFGAPIAYNLHKPLVLVRKKGKLPCETVEQSYDLEYGS
                     AVIEMHKDSIKPGQKVVIVDDLIATGGTVEAAAKLIEGLGGEVVKLVFLMELAGLKGRE
                     KLEKYDVQSVICYEGK"
     gene            16431..18740
                     /locus_tag="PGT18_RS05190"
     CDS             16431..18740
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004222985.1"
                     /locus_tag="PGT18_RS05190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_009246761.1"
                     /transl_table=11
                     /translation="MEEKREAALKAEEIEKIKKADANVKTMEDFTSPEVLYQELITSVR
                     KYHPSTDISMIDKAFQIANNAHKGQVRKSGEPYIIHPLCVAIILADLELDKETIVAGLL
                     HDVVEDTVMTSEEIREEFNAEVELLVDGVTKLGQLNYSADKVEVQAENLRKMFLAMAKD
                     IRVILIKLADRLHNMRTLKYMPPHKQKEKARETMDIYAPIAQRLGISKVKIELDDLSLK
                     YLKPEVYYDLVEKINLKKSERQAFIDQIVGDVRAHIEKASINAQIDGRIKHFFSIYKKM
                     VNQDKTIDQIYDLFAVRIIVDTVRDCYAALGIIHEMYKPIPGRFKDYIAMPKPNMYQSL
                     HTTLIGPSGQPFEIQIRTFEMHRTAEYGIAAHWKYKEVSNNGKVSVTQSEEEKMSWLRQ
                     ILEWQRDMSDNKEFLSLLKSDLDLFSESVYCFTPAGDVKTLPNGSTPIDFAYNVHSAVG
                     NKMVGARVNGKLVPIEYVIKNGDRVEIITSQNSKGPSRDWLKVVKSTQAKNKINQWFKQ
                     ELKEDNILKGKEMLIQYAKVKAISLGEIQKPKYQEAVMKKYGFRDWDSVLAALGHGGLK
                     EGQIINKLLETYNKDHKAELTDEKVLEATAEHKDKLHIGKSKGGIVVKGIHDVAVRFSK
                     CCNPIPGDEIVGYVTRGRGVTIHRTDCINVMNMSAEDRNRLIDAEWQVPAHESCERYMA
                     DINVFAYNRTGLIVDISKIFTERKIDILALNTRISKQGTATINICFEVRSKEELNSMVE
                     KIRQIESVKDIERTAG"
     gene            18750..19382
                     /locus_tag="PGT18_RS05195"
     CDS             18750..19382
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004222982.1"
                     /locus_tag="PGT18_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_004222982.1"
                     /transl_table=11
                     /translation="MKKLMLRGIVVGPVQTNCYFLKNEETQEILIVDPGAEQERIIYAL
                     DKLQGKPVGILLTHGHYDHVCAVNELREHYKIPVYAAKEEEPLLADSQQNLSAAWSGVP
                     YKVKADALLEDEEEIQAAGFEITTILTPGHTSGSCCYWIKDEEVCFSGDTVFYGSCGRC
                     DLPTGSMSEMKKSLNKIFAMLPDKTVIYPGHGEATDAEFEKKNNPYL"
     gene            19409..20860
                     /gene="hemZ"
                     /locus_tag="PGT18_RS05200"
     CDS             19409..20860
                     /EC_number="1.3.98.3"
                     /GO_function="GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004222979.1"
                     /locus_tag="PGT18_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="coproporphyrinogen dehydrogenase HemZ"
                     /protein_id="WP_004222979.1"
                     /sec_met_domain="PF04055 (E-value: 5.1e-24, bitscore: 79.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGISFNKKEFEYDAYTLVKAFYPKEDIEMYYTEEIQEEKSYDRL
                     ISILYGEKVLIRLCFDGKVREGEQAFDEAEDRKIRKNKLKQVLYQLLAEETGHTLPWGN
                     LTGIRPTKIAMGLIESGMSNAEAADYMRKTYYTSNEKTALAITIANREREILKNIDYEN
                     GYSLYVGIPFCPSICLYCSFSSSPLERWRDKVDSYLDALLKELDFIAETMKDKTLDTIY
                     IGGGTPTTLEPQQLHRLLGHIQKRFPMEQVKEYTIEAGRPDSITKEKLQAIREYPVTRI
                     SVNPQTMNAETLKIIGRNHTVEDTRHAFALARECGFDNINMDLIVGLPGEHKDDVEHTL
                     KEIQALDPDSLTIHSLAVKRAARLRMFKDQYEEMGFENNQEIMEMAMNYARSCQMGPYY
                     LYRQKNMCGNLENVGYAKVDKAGIYNILIMEEKQTIIAAGAGASTKLVSDHGQKIERIE
                     NVKDVTNYITRIDEMIERKRDGIVL"
     misc_feature    complement(21197..21210)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.07"
                     /tool="antismash"
     misc_feature    21516..21532
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 23.65"
                     /tool="antismash"
     misc_feature    21609..21621
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.88"
                     /tool="antismash"
ORIGIN
        1 acagaattgc ttcggattta taaccgattt cctttggaag aactgattgt gcatcccaga
       61 attcaaagcg attattataa gaatgagccc agaatggagc agtttcaaga ggcggtgaga
      121 tgcagtcaaa attccttatg ctataacgga gatttattca caaaggcaag atgtgaaaag
      181 ttttttgaag aatatccttc catagagaaa gtgatgttag gacggggact tttggtaaat
      241 ccggcgttgg tacagcaggt acagaaggga acagtgttgg aaaaggcaac gctaaaagct
      301 tttcatgaca agctgtgtga ggaatacata gaagttatgt caggggacaa aaatgttttg
      361 tttaagatga aggaattgtg gttctatatg ggaaacctgt ttgcagataa tcagaaatac
      421 ttgaagaaaa taaagaaatc tcagaacttg aaggaatatc aagcaatcgt agaagaaatg
      481 tttcaggtat gcccgttgga aataaaggaa taatttatga acgataaatt tttaaatcag
      541 attacagagt ttatttttgt agaggataaa gcggaaaaat cagatatgat ttttataccg
      601 ggaagtggtt ttcctcagtt agcagaggaa gcggcaaaat tatatcatca aggattagca
      661 ccttatattt tgccttcagg aaaatatagt attttaaatg gaaaatttgc aggagtacag
      721 gaaaaacagg agctttatga tggagaatat gagacggaat gggaattttt aaaagaagtt
      781 ttgaagaaaa atcaagtttc ggaagaacat attttaagag aagataaggc aacgtatact
      841 tatgaaaacg ccatttattc cagaaaagta acggattgtc tggggatgga aataaaaaag
      901 gcaattttgt gctgcaagcc ttatcatgcc agacgaagcc ttttgtacta tcagctttta
      961 tatccggaaa cacagttttt cgtgcgtccg atacaggaca gtgacgtaaa gagagagaac
     1021 tggtatctga cggaaaaggg aattcgactg gtgtttgggg aagtgcagaa gattggagag
     1081 cagtttgagg atattaccaa agaaatgagt atggaataag ataataaata gtttaacagg
     1141 aatatatcta catggctctg cagcaatggg attatagaac tgtcaacggt tcaaaaaaat
     1201 ttcggtagat attgataata tgtttgaaaa gatagtatat gtaatttgtg aataagtgat
     1261 ataataagaa atcgtagtta taaaaaacga agatgaagaa aaggaagaat tactatgaag
     1321 attacaaaaa taatattaac cacaattatg attgtggttg ctgcactagg attattccga
     1381 attctaccct tcaatataac aaattccatt atgtttactt cacttgctac tttactcttg
     1441 ctaagaagta tagagtggaa aaagagcaga gataaaacag gctttctttt tacatttatt
     1501 gccgctgtat ttatttatat cgttgttatt ttcaacattt gttcttcact tcttggatat
     1561 gagaaagtgg ataatcgaga ctgtttgaaa gatataaatc cttcagaaat agttgaaatt
     1621 aaatgttcag gaacaactgg tgggaaagac ggtcattttg agtatttctt agatgaaaga
     1681 cagcaagaag attttgtaga actgttagga aaagtgaagc tgggaagaaa agcagaaaga
     1741 gaggagacat tgtcttcagg agcagttacc tattatacat tggaatttga agatggagag
     1801 gtgttagaag tcagtcccgg aagatttttt atggtaaatg acgattatta ttattttttg
     1861 aattatgata aaatatggga tgaattttta gaattgtaga taaaattata ggctgatatt
     1921 tcacatagaa attgttgtga agtatcagcc ttctttataa ttattttctt acacggtatt
     1981 ttttatagct ttccaaaata taggagcgtg ctttttgcgc ttcttctttt ggaagatttt
     2041 ccatcccctt tagcggatat tccatattta attcagaata tttttgttct cccatgttgt
     2101 ggtaggggag aacttccagt cctttgatat ttttgtggga agcgagaagc tttccgatac
     2161 cgtccagttc ttctttggaa tttgtaaagc ccttcacaat gacgtgacgg acaaccacag
     2221 gaactcttgc tgtctccgaa gccttcagaa aatcaagaac aggtgaaaga ggatgtcctg
     2281 ttaatttttt atgttcttct gaagcactgt gcttaatatc cagcaaaatc aagtctgtat
     2341 aggaaaacag tttttgataa gcttccgctt gtttttctct gtaaagaata ccggaggtgt
     2401 caaggcaggt atggatgttt tttgactttg cggcctgaaa taatgcagtg acaaattcca
     2461 actgcatcaa aggctcgcct ccggtaacgg taattcctcc attctgataa aagcctttgt
     2521 ttttttcata gatttccaga atttcctcta cggtcataga ctgtcctttt ttgggagccc
     2581 aagtgtccgg attatgacag tacaggcagc gcataggaca gccctgcaaa aagactacaa
     2641 gtctgatgcc ggggccgtct actgtgccaa aggtttcaat ggagtgtaca aagcctgttt
     2701 tacattccgt catggaaggt tcttgagata acctcatcct gctgttcttt tgtcagcttg
     2761 tggaagttta ctgcatatcc ggacacacga acagtaagct gcggatattt ttcaggatgc
     2821 ttctgtgcat ctaaaagagt ttcctttgta aatacgttga catttaagtg atgtccgcct
     2881 ttttctgcat atccgtctaa taaatttact aagttatcga tttgagcatt actgatattc
     2941 attgaaaatt cctcctgtaa aaagtattat tgtaagtcaa tgtttggctc gcagcaagcg
     3001 cagtccggtt ctaattcaaa agcaatgtca ttaaagaaaa ctgcatcatc ttttcccaga
     3061 gcgcccggaa taatggaaaa ggtattggaa ataccatcct gtgcgtcctt aaatggaagc
     3121 ttggaaacag aatttaagga tgcaacagcg ccgtgactgt ctctgtggtg cattgggtta
     3181 gctcccggag caaatgcctg tcctgctttt cttccatccg gtgtagaacc tgttgctttt
     3241 ccatatacta cgttagaagt aatggtaagg atagaagttg taggaattcc tccacggtag
     3301 gtatgatttc ctttaatata ttccataaag gtatgaacaa tatcataagc aatatcgtca
     3361 actcggtcat catcatttcc gtattttgga aaatctcctt cgatttcata atttacggca
     3421 atgccgtttt catcacgaat tgttttaact tgtgcatatt taattgctga taaagagtcg
     3481 gcaacaacgg aaagtcctgc aatacctgtt gcaaaccagc gagttacctt cttatcatga
     3541 agcgccatct gcaatctttc gtaagaatat ttgtcgtgca tatagtgaat aacatttaaa
     3601 gtatttacat agacaccggc aagccatttc atcatatcct gaaatctgtc cataacctca
     3661 tcgtaatcta aatattcgga agtaatagga cggaattttg gaccaacctg ctttttagat
     3721 acttcgtcaa caccgccgtt gattgcatat aacaaacatt ttgcaaggtt tgcacgagcg
     3781 ccgaagaact gcatttcttt tccaatgcgc atagaagata cgcagcaggc aatggcataa
     3841 tcatcgccgt gagttacacg cattaaatcg tcattctcat actgaatgga agaggatgcg
     3901 atagaagttt tggcgcagaa gcgcttaaag tttgcaggca gctttgtaga ccataaaacc
     3961 gttaagtttg gttccggaga agtacccaga ttttccagtg tatgaaggta acggaaggac
     4021 atctttgtta caaggtgacg tccgtcaatt cccataccgg cgatggactc tgttacccaa
     4081 gtagggtcgc cggaaaacag cgcattgtat tcaggggttc ttgcaaattt cacaagacgc
     4141 agcttcatga taaaatggtc gataaattcc tgaatttgtt cttctgtgaa ggtattgttc
     4201 tttaagtcac gttctgcata aatgtcaagg aaggtagaag tacgtccaag tgacatggca
     4261 gcaccgttct gttccttaat ggcagcaaga tagcccagat ataaccactg gatagcttcc
     4321 tgcacattgg cagcagggcg ggaaatatca aatccgtaaa ttttacccag ctcttttaat
     4381 tcttttaaag cacggatttg ttcggataat tcttcacgtt ctcttgttac atcagagtac
     4441 atggtagtac gtgtggtatt tttttcattt tctttatctt caatcaggcg gtctacaccg
     4501 taaagagcca cacggcggta gtcgccgata atacgtcctc tgccgtaagc atccggaagt
     4561 cctgtgataa tatggctgga acggcatgcg cgcatttccg gtgtgtaagc gtcaaataca
     4621 ccgtcattat gtgttttgcg atgcttggta aaaaattcaa caacctcagg gtctacgtga
     4681 tagccattgt cctcacaggc tttcattgcc atacggatac cgccgtaagg ctgtaaggag
     4741 cgtttaaaag gtttgtctgt ctgaaaacct acgattgttt ctaaatcttt atctaaatat
     4801 cccggtccgt gagaagtgat ggtggaaatg atttttgtat ccatatccag tacaccgccc
     4861 ttttcctgtt cctgctttgt aagctccata acctgctccc aaagcgtctg tgttgctttt
     4921 gtaggacctg caaggaaggc atcgtcaccg tcgtaaggag tgtaattctt ctgaataaag
     4981 tcccttacat ctatctcttt tgtccaattt cctttgttaa aggaaatcca ttcttctctc
     5041 ataagtctgt gtcctcctat atcttgtggt tagttgtaca taactttcct tgtatagggg
     5101 gattttataa tattggacta agaaagtcaa ggtggtattg tgtttataat tcaatacaaa
     5161 gaaaatttta ttttggaaaa tccttcgcct gcggtgggcg ctttcgtaat aaaaaaagag
     5221 cttcttaatt aaaagaaact cttttcatag aaaaacatct tatttttcgg agatttcagg
     5281 aagttcattt tcttcttctt cctcatgtgg ctcatatttt tcaaagactt ttcttaaaat
     5341 aatggagcat acataagcca cactggcaaa gcccaaaagc agccacagca tactgccgta
     5401 caccagtgtt gaagctgtta agaaggttag aaatcccagt cccagaggaa taagcattaa
     5461 aagaatggtc caagggagat ttaaaattgc aattaacaga gaatttttaa aaatattttt
     5521 aatattattt atgaaacgcg ccgtatatgg gaaaacatat accagtatca taaaataaag
     5581 aatacctaat gcaccgatta aaatctggaa aattgtgctc atattccccg gaaggaaggc
     5641 agtagcacga taatcaacat aaataaaaat tccgatagct gccataatca gccagataat
     5701 cgtagactgt ttgaaatttt ctttaaaggc ttttaagaag cctttgaaaa tataagactc
     5761 ttctccacgc accattttca gagtaacggt atacatggcg gtgacagaag cgccggcagt
     5821 aataatagga atacaaaata caatacataa aatatttaaa atcataatat cgcatacacg
     5881 ggacagaaaa cgcataatcg gactgtccat attaaacaag ctgctcataa taaaaatcct
     5941 ttcctgtttt aaatttattc gtcaaaattt tcttcggttt tttcaggaag ataaatatga
     6001 acggtttcga tacgatttcg ttctgcttta tctacaacaa gttttacacc gccatctgtg
     6061 gtgacggact cgccggcagc aggaaatctg tcgagctgtt caatgatata gcctccaatg
     6121 gagtcataat catcagaaac aatattcaag tgaagtgttt catctaaatc gtcaagtctg
     6181 gcagaaccaa gagcgatata ctcacggttc gggataattt cacgaagctc ttcttcctct
     6241 gagtcatatt cgtcatggat gtcccctaca atttcttcaa ttaaatcttc cagagtcaca
     6301 ataccggagg tcgctccgta ttcatccaat acaacggcaa aggttactga attttctttc
     6361 atttccatca gaagctcaga ggttcgtttg tattcgtaag tgaaataagc ctctcttaaa
     6421 attttccgca cggaaaaatc ttccttgctt gtaagaagca ggtcttttac attgacaata
     6481 ccgataatat tgtcggtggt atcctcaaag acagggaagc gtgtatgctt ttcatcacga
     6541 aacagaccga ctaagtcttc atatgaactg tttacatcag cgaaggttac atcaatacgt
     6601 ggtatcatga catcttctgc ctgagagtcg ccgaaatcaa atacattata aatcatttga
     6661 cgttcttcgc tttcaataac tccttcttca tgtcctacat ttaccaaagt acgaagctca
     6721 tgctcggtaa tggtattgca ttttgcattg gcatcaatcc gcatcagcgt cagaacaccc
     6781 tgcgccagct tattgataat aaagataatc ggcgtcagaa tgaacattaa aatgcgaatg
     6841 acttttgcat aagacagtgc cattttttcg gaatgtacag ttgccagagt ttttggagtg
     6901 atttccccaa agattaagac cagaagagta ataatacccg tactgatact tacggcagca
     6961 ctgccgaaca agcgcatggt aagcgtagtg gcaagggaag atgcactgat gtttacaatg
     7021 ttgttaccga taagaatggt actcagaagc ttgccggagt cttcaattac gttcaaaagt
     7081 gtcagggctc gcttgtcccc ttggtcggct aaagcttgaa tacgaatttt gttcactgtt
     7141 gtcatagaag tttctgctga tgaaaaaaat gcggaaaggc aaatgagaat aatcaaaatc
     7201 agaaactgta tggcgtcact ggaatccaat atgttcaact ccttttgata ataaattata
     7261 gctttggcta ttaaagtcta atatacatga tttttatttg gattgcaaga aatctgtatg
     7321 aaatccacgg gaaaaaagtt gatttttggg ggtgtcggaa aaaagaaaat tgtgttatac
     7381 taaatcagaa taacaaaaac tgaacttgtt cacatttgat ttagaaaggg aataagggaa
     7441 atgaatagaa ataaaaaaaa tttacataaa gtggcagcca atgtactggg tgttaccctt
     7501 gcttctgcac tggtgacagg agcagtggca gagacagcgg ctccaattgc tgtatttgct
     7561 gcacagcagg aagcacagac gcaggagaag attatctact tgaacggaag tattcaggca
     7621 ggagaaaatg ctgacggaac cggtcaggcg caggcagtgg actcctttga aaaggcattt
     7681 gccttggcag gaggacaggg aacggttatg gtatgcggta tggtcaatgt cagcacagaa
     7741 aagaagcttc atattcctgc gggagttaag ataaagagaa atgccggatt tacaggagct
     7801 ttggtaaagg ttacaggcaa aggaaagctt acggtaacgg gagacggcat tacagcacag
     7861 gatgtggacg tttcaacggc agaaagcgga aaaggggcat ttgttgccgc aaaaattcct
     7921 caggtggtga tgcctgcaca gattaccctg aacaatctgg cagagtggaa tacttgtagt
     7981 tttcctcttt tgggatttac gggagaaggt gcttttacat ggggaacaca ggtacctccg
     8041 tcttcttacg aaacagagat gaaggtggtg tttacaccga aggatacaga aaactatgac
     8101 tactcacagg tttccggttg ggataatcag agtaaaacag taaccagaac cataaaagta
     8161 tttattgaag cattaaaacc tcaggtggag gagccggcaa agccaatggc agaggttcaa
     8221 attccttctg aattaaaatt tgctactaag gaagaattta aaaatctgga ttttgcaaat
     8281 gccggattta aaggagaagg ggtgtttgcg tgggaagcac agacagaacc gtcttcttat
     8341 gaaacaaaga tgaatgtagt ttttactcct tctgatatag agaagtacga ctatacacag
     8401 actgccggat ggaacgggga aagtaagaaa attgttcggg aagtgaaggt gtttattgag
     8461 gaattaaagg aaaatacgac agagcctgag acaccacagc cggaggttcc tgaaacagaa
     8521 gtaccggaga ctgaaaaacc tgagaccgaa acgccggaga caactcctcc gacagagccg
     8581 gaaaatcctg acacacagga gccggaagta ccacagacag aagctcctga agcagaagta
     8641 ccggagactg aaaaaccgga aaacggcggt gtggaaattg aatacgtaaa tcctgatgag
     8701 gttgtacagc cggaagagga aacacagccg gaggttactt atcaggcaga ggcaggtcaa
     8761 aacggagaga ttgcacagga ggctccggaa gcgctccctg ttggaagctt gattgacgaa
     8821 acaggcgtac aggtgtccgg tgactttatt ccttattatg tggatttgca ggttacttat
     8881 aatgaagcag tcaatgagct tccggatgcg ggaattggcg aaatcctttc tgcttatgaa
     8941 ttgaagctct gggatttaaa agaggataag gaatatcaaa tcccggaagg aagaaaagta
     9001 aaagtgctta ttcctttgcc ggaaaatgca aattgttttt cagatttatc cattgcacat
     9061 tatctgggca ataaccggta tgaatacttt gtattttcca aggatggaaa aacagggaat
     9121 atgacagtgg aagagaagga cggagcagaa tatctggctt ttgagacggc ttctttcagt
     9181 cccttcaatg taggcggtca tcagattgta ggtccgggtg taaacagtga caatcataaa
     9241 ccttcaacag gaacgtcaca gtcaacgaca cagacaaagc cgaatacttc cgcatcaaat
     9301 tcttctgcgc agagtaccgt aaaaccgaat acacagaaaa aacctgcaca gaataataca
     9361 acaccggttg ttcaaattgt gaaaacagga gatgagtcaa aaaccgtatt ttatgtactg
     9421 attggtttcg gtgctctcat tattgcagga cttgctgttt tttttggaaa aaagaaaaaa
     9481 tagaaaaaag ttatgagtta caaatccctc ccatatattg attataggag ggatttttta
     9541 tggaaaaaag agtttcaaaa aatgcaaagc caatgctgat gataaaagcg cttttgcttg
     9601 cctatgcagc caccggaatt ttacttctta ttctggcatt tttgctgtat aagatgggac
     9661 ttggcgagag tcagataaac ataggaatta tggttacata cattgtatcc tgcctctttg
     9721 gcggatttta tatgggaaaa aagataaaag tcagacggtt tgcatggggt atgggagtcg
     9781 gtacgggata tgccgttctt cttatggcag ttacctttct gacagtgcat cagataagcg
     9841 gagattttaa ggaaatgctc atgatgtttt tcctgtgctt tttcggaggt actctgggag
     9901 gaattttagc gtgaatttct acttgctagg cggttgcagc tatgctataa taccgctaga
     9961 tgttatatct taaaattatc atacatggga ggattatgtt atggaacata tcaaaacatt
    10021 aaatacaaaa agcttacaga atacagtaaa aaaaggcgga tgcggtgaat gtcagacatc
    10081 ttgtcagtct gcatgtaaaa catcctgcac agtaggaaac cagagctgcg aacacaaata
    10141 aaataacaca gtgcgttttt ttctgggcac atggctgaac agcagcggtg taaaagccgc
    10201 tgcttaatta ttgcatggga gacttagtct cccatgcaat aattaacgct ccgcgaggag
    10261 cgcactgcgg cagaaaggaa ttatagaaaa ttgtgttaca gagaattgcg ctgggtagat
    10321 agaaacagaa aggagaaata cggtgataca tcgttataaa aataatggct ataacattgt
    10381 gctggacgta aacagtggtt ccgtacatgt agtcgatgaa ttggtttatg atgtaatcgg
    10441 acttctggat gaagggcagg aagaagctgt tgtttatgag aagttaaagg atacatataa
    10501 aaaagacgat atccagacag cattgaagga aatacaggaa ttaaaagatg cggaaatgct
    10561 gtttactgag gatatttatc gaaatgccat tgagcatttt aaagaaagag aaacagtggt
    10621 aaaggcattg tgtctgcata ttgcccatga ctgtaatctg gcatgcagat attgttttgc
    10681 ggaagaagga gaatatcacg gaagacgagc tttgatgtcc tatgaagtag gaaaacaggc
    10741 tctggacttt ttaattgcaa attccggcaa cagaaagaat ttagaggtag acttcttcgg
    10801 cggcgagcct ttgatgaact ggcaggttgt taaggattta gttgcttacg gaagagagca
    10861 ggagaaaatt cacaataaaa atttccgctt tacgttaacc acaaacggtg tgcttttaga
    10921 tgacgaaatc atggaatttg ccaataaaga aatggcaaat gtagtattaa gtattgacgg
    10981 aagaaaagaa gtacatgact ttatgcgtcc gtttagaaaa ggagcgggaa gttatgactt
    11041 ggtagtgccg aagttccaga aatttgcaaa gagcagagga gaaaagagct actatgcaag
    11101 aggtactttt acacgtcata atttagactt ttccgaagac gtactgcatc tggctgattt
    11161 gggctttgat cagatttccg tagagccggt agtagcagat gaaaaagagg aatacgcact
    11221 gaaatgggaa gatgttccga aaatctgtga agagtatgac aagcttgcaa aggaaatgat
    11281 aaagcgtaaa aaagaaggaa aaggatttaa tttcttccac tttatgattg atttgacagg
    11341 cggtccttgc gtatataaac gtttgtcagg ctgcggttca ggtacggagt atctggctgt
    11401 gactccgtgg ggtgatttat atccatgtca ccagtttgta ggtgaagaaa aatatctcat
    11461 gggaaatgtg tgggatggtg taaaacgtac agatttatgc aaagaattta aaaattgcaa
    11521 tgtatatgca aaagaaaaat gtcagaactg ctttgcgaaa ttctattgca gcggtggttg
    11581 tgcggcaaat tcctataatt tccatggctc tatcaacgat gtttatgaat tgggatgtga
    11641 gcttcagaga aaacgtgtag aatgtgccat tatgttaaag gcggccgagg cggcagaaga
    11701 acaagaaaat taagcaaaga agggaaagac aatgaagaaa aacagaggga tacttgtact
    11761 ggttttaaca gcaatcatta cagggtttct gatttttacc accgcagtag gatttggtcc
    11821 taccggtaca ggtgctgcaa aaaatattaa gacaggtctg gatttgtccg gcggtgtaag
    11881 tattacatac gaagcatcca aagagtcacc gacagaagat gaaatggcag ataccattta
    11941 taagcttcaa aaacgtgtgg aaaattatag tacagaagca caggtttata aagaagggga
    12001 aaatcgtatt atcgtagaaa tccccggagc aaaagatgca aataaaatct tagaagaact
    12061 gggaaaaccg ggttctctgt attttattaa acataaagac tctgccggtg gagaaaacta
    12121 tactttgaat acagaaaccg gcgaatatga gcttgcaaaa accattgaag aaatcgaagc
    12181 ggacggcggt attgttctga caggaacaga tatcaaggac gcaaaagctg cggtagcgca
    12241 ggatgatttg aaaaacaatg taaacgtagt aagcttatcc tttacaaaag aaggaacaga
    12301 caaatttgcc gctgccacaa aagaagcagt ggaagccggt aatgatacca tcggtattta
    12361 ttatgacgga acttttgtca gtgttccaag tgtaagacag gaaatcaaag acggacaggc
    12421 acagattgac ggtatgaaag atgcagcaga ggcagaaaat ctggcatcta ccattcgtat
    12481 cggaggtttg aaactggaat taagcgaact tcgttccagt gtagttgcgg cgcagttagg
    12541 tgaaaaagca atttcaacca gtttggtagc agcggctatc ggacttgcgc tgattatctt
    12601 atttatgatt tttgtatatc gtattccggg actggtatcc ggtattgcgt tgattattta
    12661 tgtatgtctt gatttgattg cgttaaatgc ctttgatttg actttaacct tacagggtat
    12721 tgccggtatt attctgtcaa tcggtatggc ggtagatgcc aatgttatta tttatgcccg
    12781 tattcaggaa gaaattgctt ccggaaagag tgtcagaacg gcacttcaga acggatttaa
    12841 aaaagcattt tctgcaattt ttgacggtaa cattacaact ttaattgcag cctttgtatt
    12901 gaattggctt ggttcaggaa cagtaaaagg atttgcacag actctggcgc ttggtattgt
    12961 actgtctatg tttaccgcat tagtggtatc aaaatatctg atgtatgcag tatatgccgt
    13021 tggcgtgaga aatgagaaat tctacggaaa gagaaaagaa agaaaaccaa ttcctttctt
    13081 acagaagaga aaagtattct ttgccgtgtc tcttattctg attttatgcg ctcctgtttc
    13141 tatgctgatt ttcaagggaa caacaggaga gtccctgaaa tacagtctgg aatttaaagg
    13201 cggtacttcc acaaatgtag aatttgacaa ggacatgagt attgcggaaa ttgatgaaaa
    13261 acttacacct ttagtagaag aagttacagg tgataagaac gttcaggcaa caaaagtagt
    13321 aggcaataat caggttatta ttaaaaccag aactttgaat gtagagcaga gagaaaagct
    13381 ggaaacagct ttaatagata attttggcgt agcacaggaa gatattacat cagaaagtat
    13441 ttcttctacg gtcagcaacg aaatgcgtgc agatgcagta aaagctgtaa tcgtagctac
    13501 ggtactgatg ctcttataca tctggttcag atttaaggat atccgttttg caagcagtgc
    13561 ggttattgcg cttctgcacg acgtactggt tgttctggca ttctatgctg ttgcaagggt
    13621 ttctgtggga aataccttca tcgcatgtat gctgacgatt gtaggttact ctattaatgc
    13681 tacgattgtt atctttgacc gtatcagaga aaatctggca agtgcgggca agaagacaga
    13741 tttggaaaca ctggtaaatg ccagcattac acagacactt acaagaagta tttacacttc
    13801 cttgacaacc tttattatgg tattcctgtt attcattatg ggagtttcct ctattcgtga
    13861 atttgcactg cctcttatgg taggtattgt atgcggcgga tactcttctg tatgtattac
    13921 aggcgctctt tggtatgtca tgaagaaaaa atttaaaaaa cagaattaaa ctcagaaaaa
    13981 aggagttgtt acattaaagt gacagctcct tttggaatta taaggtgata atatggaaaa
    14041 atgggtagtt gctgccaaga aggcagattt tcaggggatt agcaatcgct tcggagtaga
    14101 tcctgtgatt gcaagactca ttcgaaatcg agaacagatt accgatgaag aaattgatac
    14161 ctatcttcac ggagagctca gaaatttaca tccgtggaaa gcgttaaaag gaattgatga
    14221 attattaaat attttgattg aaaaaataca gcaaaagaaa aaaatcagaa ttatcgggga
    14281 ttatgatatt gacggtgtat gctctacata tattcttttt caaggcttga aaaaagccaa
    14341 tgctttggca gacgtagata taccggacag aatgaaagat ggatacggta tcagcaagga
    14401 gctgattgag cgggcatatg aaaaagaaat tgatactatc attacctgtg acaacggtat
    14461 cagcgccata gagcagattg cttatgcaaa agagaaaaat atgacagttt tggtaacaga
    14521 ccatcatgaa atcccctatg aggagaagga agacggaagc atagagcggt ttttgccaaa
    14581 tgcagatgcc attgtaaatc caaagcagga gggctgcacc tatcctttta aagaaatctg
    14641 cggagcaatg gttgcattta aggtagtatg ggggctgttt gaaaagcgta acattcctct
    14701 ttcggagatt gaggaactta ttcccattgc tgctattgct accgtgggag atgttatgga
    14761 tttagtagat gagaacagga ttttggtaaa ggaagggctg aaacgcatcc agaatacaaa
    14821 taatgaaggt ttaaaagcgc ttattcgtgt caacaatctg gaaaacagag aaattaccgc
    14881 atatcatatc ggatttgtat taggtccgtg tatcaatgcc agcggaagat taagcactgc
    14941 aaaaagagct ctggaattac tgctttcgaa agataccaag gaagcctctg tgctggcaga
    15001 ggatttgaaa gaattaaacg acagccgtaa ggatatgacc gtaaaaggtg tagaaagagc
    15061 agtagaaata attgaaaata cagagctgaa aaatgaccgg gtactggtag tatatcttcc
    15121 cgaatgtcat gaaagtctgg cgggaattat tgccggacgt atcagggaaa ggtatacaaa
    15181 gcctgtcttt gtgcttacaa agggagaaga aggcgtgaag ggctcaggtc gttctattga
    15241 ggcttatcat atgtttcagg aaatggtaaa atgcagggag ctgctgacaa aattcggtgg
    15301 gcatcccatg gcagcagggc tttctatgga agaagaaaat attgagaaat ttcgaagaaa
    15361 attaaatgaa aactgtacgc tgacagaaga agacatggta gaaaaaattg tgattgatgt
    15421 tcctatgcca atgtcttatg ttaccattcc tcttattcgc cagttagggc aattagaacc
    15481 ctttggaaaa ggaaatacaa aaccgatttt tgcacaaaaa gatattcgat tttcaaactg
    15541 caaggttttc ggaaaaaaca gaaatgtagt aaaaatgaaa gcgcaggata gttttggatt
    15601 tggggcagaa tgtatttggt ttggagacgg agacgagttt ttggaacgct taaaagagaa
    15661 ggatgtgtgg gatgtaattt attatccttc tgttaattct tttcagggaa gagagagcat
    15721 tgagatgatt attcaaaata tccgttgagc aaaaataaaa tttgcgtctg caaagaaaag
    15781 atgatatact aaaccacata aaaaacacaa aaaaatcaca aaagtgacat aatttgatat
    15841 aaagggcagg gaaacgcaat ggaagattgt aaaaagaaaa aaattgaaga ctatgtcaga
    15901 agcattcctg attttccgca ggagggaatt atctttcggg atgttaccag tattttagaa
    15961 gatgcagacg gatttgcact ggcagttgac tctatgcaga agcttttgga aggcgtggat
    16021 gttgacgtta tcgtaggaac agagtccaga ggatttattt tcggagcgcc gattgcgtat
    16081 aatttacata aaccgcttgt attggtaagg aaaaaaggga agctgccatg tgaaaccgta
    16141 gagcagagct atgatttaga atacggaagc gctgttatcg aaatgcacaa ggactccatt
    16201 aaaccgggac aaaaagttgt tatcgttgat gatttaattg caacaggcgg aaccgtagag
    16261 gcagcggcaa agctcattga aggtcttgga ggagaagttg tgaaattggt cttcctcatg
    16321 gagctggcag gattaaaagg aagagaaaaa ttagagaaat atgacgttca atctgtaatt
    16381 tgttatgaag gaaaataaaa tcggttgatg gataagaggt gacgtttttt atggaagaaa
    16441 aaagagaagc tgccttaaaa gcagaagaaa ttgaaaaaat taaaaaggca gatgccaatg
    16501 tgaagaccat ggaggatttc accagtccgg aggtacttta tcaggagctg ataaccagtg
    16561 ttcggaaata ccatccatct actgatattt ccatgattga taaggcattt cagattgcca
    16621 ataatgctca taaaggacag gtgagaaagt ccggcgagcc ttatatcatt catccgcttt
    16681 gtgtggcaat tattttagct gatttagagc ttgataagga aaccattgta gccgggcttc
    16741 ttcatgatgt ggtagaagat acggttatga cctctgagga aattcgggaa gaatttaatg
    16801 cagaggtaga gcttttggta gacggtgtaa caaagctggg acagttgaat tattccgcag
    16861 ataaggtgga ggtgcaggca gagaatttaa gaaaaatgtt tctggcaatg gcaaaggaca
    16921 tccgtgttat tttgattaag ctggcagacc gtctgcataa tatgcgaacc ttaaaataca
    16981 tgccgcccca taagcagaag gaaaaagcca gagagacgat ggatatctat gctcccattg
    17041 ctcagcgtct gggtatttcc aaagtaaaaa tcgagctgga tgatttgtct ttgaaatatt
    17101 tgaaaccgga agtttactat gatttagtag agaaaataaa tctgaaaaag agcgagcgtc
    17161 aggcgtttat tgaccagatt gtaggagatg tacgtgcgca cattgaaaaa gcgtccatca
    17221 acgctcagat agacggaaga attaagcatt tcttcagtat ttataagaaa atggtaaatc
    17281 aggataaaac cattgaccag atttatgatt tgtttgctgt acgaattatt gtagatactg
    17341 tgcgtgactg ttatgcggcg cttggtatta ttcatgaaat gtataagccc attccggggc
    17401 ggtttaagga ctacattgct atgccgaagc cgaatatgta tcagtctttg catactacgc
    17461 ttatcgggcc aagcggacag ccctttgaaa ttcagataag aaccttcgaa atgcacagaa
    17521 cagcagagta tggtattgct gcccattgga aatacaaaga ggtttccaac aatggaaaag
    17581 tcagcgttac acaatcagaa gaagagaaga tgagctggct gcgtcagatt ttggaatggc
    17641 agcgggatat gtctgacaat aaagagtttt taagcctttt aaaaagtgat ttggatttgt
    17701 tttccgaaag cgtgtactgc tttactcccg caggagatgt aaagacactg ccaaacggtt
    17761 ctacaccgat tgattttgct tataatgtcc acagtgcagt gggaaataaa atggtagggg
    17821 caagagtaaa cggaaagctg gttcccattg aatatgtgat taaaaacgga gaccgtgtag
    17881 aaattattac ttctcaaaat tccaaaggtc ccagccgtga ctggttaaaa gtagtaaaga
    17941 gcacgcaggc aaaaaataag attaatcagt ggtttaagca ggaattaaaa gaggataata
    18001 ttttaaaggg taaggaaatg cttatccaat atgctaaagt aaaggcaatt tctctcgggg
    18061 aaatccagaa gccaaaatat caggaagcag ttatgaaaaa atacggcttc cgagattggg
    18121 actctgtttt ggctgcgctg ggacacggag gcttaaaaga gggacagatt atcaataagc
    18181 ttcttgaaac ctataataaa gaccacaagg cagagctgac agatgagaag gttttggagg
    18241 caacagcgga gcataaggat aagcttcata tcggcaaatc caaaggcggc attgtggtaa
    18301 aaggaattca cgatgtggca gtgcgtttct ccaaatgctg caatccaatt ccgggagacg
    18361 aaatcgtggg atatgtaaca cgaggcagag gcgttaccat tcatcgtaca gactgcatca
    18421 atgtgatgaa catgtccgca gaagacagaa atcgtttgat tgatgcggag tggcaggtac
    18481 ctgcccatga aagctgtgaa cgctacatgg cggatatcaa tgtgtttgct tataaccgta
    18541 ccggcttgat tgttgatatt tctaagattt ttacagagag aaaaatcgat attcttgctt
    18601 taaatacaag aataagcaaa cagggaacag caaccattaa tatttgcttt gaggtaagaa
    18661 gcaaggaaga attaaacagt atggttgaaa aaatcagaca gattgaaagc gtgaaagaca
    18721 ttgagcgtac tgccggttaa ggagaaaaga tgaaaaaatt gatgctgaga ggaattgtgg
    18781 taggtcctgt acagaccaac tgttattttt taaaaaatga agaaacacag gaaattttaa
    18841 tcgtagaccc gggggcggag caggaaagaa ttatttatgc tttggataaa ttacagggaa
    18901 aacctgtggg gattttattg acacacggac attacgacca tgtgtgtgcg gttaatgagc
    18961 tgagagaaca ttataaaatt ccggtatatg cggcaaagga ggaggaaccg ctccttgccg
    19021 acagtcagca gaacctttct gctgcatggt caggagttcc gtataaagta aaagcagacg
    19081 ctttactgga ggatgaagaa gaaattcagg cagcgggctt tgagattacg actattctta
    19141 caccggggca tacaagtggc tcttgttgct attggattaa ggatgaggaa gtctgcttta
    19201 gcggagacac ggtattttac ggaagctgtg gcagatgcga ccttcctacc ggaagtatga
    19261 gtgaaatgaa aaagagctta aacaaaattt ttgccatgct gccggataaa acggtgattt
    19321 atccgggaca cggagaagcc acagacgcag agtttgaaaa gaaaaataat ccttacttat
    19381 aagaataata tagaaagagg aagagcccat gataggaatt tcctttaata aaaaagaatt
    19441 tgaatatgat gcctacacct tggtaaaggc tttttatccg aaagaggaca tcgaaatgta
    19501 ttatacagag gaaatacagg aggaaaaaag ctatgacagg ctgatttcca ttctttacgg
    19561 agaaaaggta cttatccgac tgtgctttga tgggaaagtg cgtgagggag aacaggcatt
    19621 tgacgaagca gaagacagaa aaatcagaaa aaataaatta aaacaagtgc tgtatcagct
    19681 gttggcggag gaaaccggtc atacacttcc ttggggcaat ctgaccggta ttcgtcctac
    19741 gaaaattgcc atgggactta tcgagtccgg tatgagcaat gcagaagcag cggattatat
    19801 gcgaaaaaca tactatacca gtaatgaaaa gacagcgctt gccattacca tagctaacag
    19861 ggaaagagaa attttaaaga atattgatta tgagaatgga tacagcttat atgtgggaat
    19921 tccattttgc cccagtatat gtctgtattg ttcttttagc tcttcacctt tagaaagatg
    19981 gcgtgataaa gttgacagct atttagatgc actgctaaaa gagctggatt ttattgcaga
    20041 aaccatgaaa gataaaacct tagataccat atatataggt ggaggaactc ctacaacctt
    20101 ggagccgcag cagcttcatc gcctgctggg acatatacag aagcgttttc cgatggaaca
    20161 ggtaaaggaa tataccatag aagcaggaag accggacagc attacaaaag aaaaattaca
    20221 ggcaattcgg gaatatcctg ttaccagaat ttctgtaaac cctcagacca tgaatgcaga
    20281 gaccttaaag attatcggaa gaaatcatac ggtggaggat acacgacacg ccttcgcttt
    20341 ggcgagggaa tgtggatttg ataatatcaa tatggattta atcgtaggtc ttccggggga
    20401 gcataaggat gatgtggagc atacattaaa ggaaattcag gcgcttgacc ctgacagtct
    20461 taccatacat tctttagcag taaaaagagc tgcaagactt cggatgttta aagaccaata
    20521 cgaagaaatg ggatttgaga acaatcagga aatcatggaa atggcgatga attatgcccg
    20581 aagctgtcag atggggccgt attatctgta cagacagaaa aatatgtgcg gaaatctgga
    20641 aaatgtaggc tatgcaaaag ttgacaaagc aggaatttac aatatactta taatggaaga
    20701 aaaacagacc attattgcag caggggcagg agcatccacg aagcttgtgt ctgaccacgg
    20761 acagaagatt gagcgtattg aaaatgtaaa ggatgttacc aattacatta cccgtattga
    20821 tgaaatgatt gagagaaaaa gagacggaat tgtattgtaa aaaagatagg agacgataag
    20881 tatgagttta aagaaaaaac cggtaaccgg tatgaaagat attttacctc aggaaatgga
    20941 aatccgtgat tatgtaatcg gcttaatcaa ggatacttat aaacagtttg gatttacttc
    21001 catggaagca ccttgtgtag agcacattga gaaccttacc agtaagcagg gcggtgacaa
    21061 tgaaaagctg attttccgta ttttaaaaag aggcgagaag ctgaaaattg aggaagcaaa
    21121 ggaagaaaat gatttggtag acagtggtct gcgttatgac ttaaccgtac ctctttgccg
    21181 tttttattcc aataatgcaa atgagctgcc gcagccgttt aaggcgcttc acattggaaa
    21241 tgtatttcgt gcagaccgtc ctcagagagg tcgtttccgt cagtttatgc agtgtgatat
    21301 cgacatttta ggtgacccga catttttagc ggaaattgac gttattctgg caacgtctac
    21361 tttagtggga aaattggact ttgacagctt tactattcgt atcaacgaca gaagaatttt
    21421 aaaggcaatg gcagcgtaca gcggatttcc ggaagactcc tttacacagg tgtttattat
    21481 tctggataaa atggataaaa tcggcatgga cggcgttgca aaagaattgg aagagtctgg
    21541 ttttgcaaaa gagagcgtag aaaaatacat ggatttattc aaagccatgg gaaatggtat
    21601 cgacggtgtt gcttattgca aagaaaagct ggagggcttt ttagatgcga aggttgcaga
    21661 tgatttgaca accattatcg aaagcgttat gcaggcaaaa acagcaaact tca
//
