Select genomic region:
Overview
1.1
23.1
31.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAQEAZ010000001.1 (Blautia hansenii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 176,672 | 197,562 |

NZ_JAQEAZ010000003.1 (Blautia hansenii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | ranthipeptide | 78,755 | 100,467 |

NZ_JAQEAZ010000004.1 (Blautia hansenii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 31.1 | lanthipeptide-class-i,cyclic-lactone-autoinducer | 1 | 24,853 | Low | nisin O | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 176,672 | 197,562 |
Region 23.1 | ranthipeptide | 78,755 | 100,467 |
Region 31.1 | lanthipeptide-class-i,cyclic-lactone-autoinducer | 1 | 24,853 | Low | nisin O | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_JAQEAZ010000010.1 (Blautia hansenii)
  NZ_JAQEAZ010000011.1 (Blautia hansenii)
  NZ_JAQEAZ010000012.1 (Blautia hansenii)
  NZ_JAQEAZ010000013.1 (Blautia hansenii)
  NZ_JAQEAZ010000014.1 (Blautia hansenii)
  NZ_JAQEAZ010000015.1 (Blautia hansenii)
  NZ_JAQEAZ010000016.1 (Blautia hansenii)
  NZ_JAQEAZ010000017.1 (Blautia hansenii)
  NZ_JAQEAZ010000018.1 (Blautia hansenii)
  NZ_JAQEAZ010000019.1 (Blautia hansenii)
  NZ_JAQEAZ010000002.1 (Blautia hansenii)
  NZ_JAQEAZ010000020.1 (Blautia hansenii)
  NZ_JAQEAZ010000021.1 (Blautia hansenii)
  NZ_JAQEAZ010000022.1 (Blautia hansenii)
  NZ_JAQEAZ010000023.1 (Blautia hansenii)
  NZ_JAQEAZ010000024.1 (Blautia hansenii)
  NZ_JAQEAZ010000025.1 (Blautia hansenii)
  NZ_JAQEAZ010000026.1 (Blautia hansenii)
  NZ_JAQEAZ010000027.1 (Blautia hansenii)
  NZ_JAQEAZ010000028.1 (Blautia hansenii)
  NZ_JAQEAZ010000029.1 (Blautia hansenii)
  NZ_JAQEAZ010000030.1 (Blautia hansenii)
  NZ_JAQEAZ010000031.1 (Blautia hansenii)
  NZ_JAQEAZ010000032.1 (Blautia hansenii)
  NZ_JAQEAZ010000033.1 (Blautia hansenii)
  NZ_JAQEAZ010000034.1 (Blautia hansenii)
  NZ_JAQEAZ010000035.1 (Blautia hansenii)
  NZ_JAQEAZ010000036.1 (Blautia hansenii)
  NZ_JAQEAZ010000005.1 (Blautia hansenii)
  NZ_JAQEAZ010000006.1 (Blautia hansenii)
  NZ_JAQEAZ010000007.1 (Blautia hansenii)
  NZ_JAQEAZ010000008.1 (Blautia hansenii)
  NZ_JAQEAZ010000009.1 (Blautia hansenii)

Compact view
NZ_JAQEAZ010000001.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 176,672 - 197,562 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase
PGT18_RS01000: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: back translocase
PGT18_RS00935: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase
PGT18_RS00960: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

PGT18_RS00965: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.37 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000633.3 |  | 0.37 | terpene | carotenoid | Streptomyces avermitilis
BGC0001604.3 |  | 0.36 | terpene | gibberellin | Fusarium fujikuroi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.37 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000633.3 |  | 0.37 | terpene | carotenoid | Streptomyces avermitilis
BGC0001604.3 |  | 0.36 | terpene | gibberellin | Fusarium fujikuroi

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
PGT18_RS00960: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.16 out of 29.25
Confidence: medium
Additional weak hits (1):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.65 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_JAQEAZ010000003.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 78,755 - 100,467 nt. (total: 21,713 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
PGT18_RS05195: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002138.2 |  | 0.37 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670
BGC0001387.5 |  | 0.33 | other (other) | nucleocidin | Streptomyces calvus
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0001860.4 |  | 0.32 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0001155.5 |  | 0.31 | ribosomal | GE2270 | Planobispora rosea
BGC0000604.4 |  | 0.31 | ribosomal | GE2270A | Nonomuraea sp. WU8817
BGC0001002.5 |  | 0.30 | NRPS, PKS | jawsamycin | Streptomyces roseoverticillatus
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001591.4 |  | 0.29 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002138.2 |  | 0.37 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670
BGC0001387.5 |  | 0.33 | other (other) | nucleocidin | Streptomyces calvus
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0001860.4 |  | 0.32 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0001155.5 |  | 0.31 | ribosomal | GE2270 | Planobispora rosea
BGC0000604.4 |  | 0.31 | ribosomal | GE2270A | Nonomuraea sp. WU8817
BGC0001002.5 |  | 0.30 | NRPS, PKS | jawsamycin | Streptomyces roseoverticillatus
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001591.4 |  | 0.29 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.07 out of 18.46
Confidence: medium
Additional weak hits (5):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.82 out of 39.62
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.59 out of 27.18
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.65 out of 30.98
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (78754...100467)
PGT18_RS05170
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 0 - 99
  Score: 111.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
RpoN | Regulator of nitrogen assimilation and virulence

NZ_JAQEAZ010000004.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 24,853 nt. (total: 24,853 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
PGT18_RS05880: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

PGT18_RS05890: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000538.3 |  |  | 0.44 | ribosomal | nisin Z | Lactococcus lactis
BGC0001289.5 |  |  | 0.43 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002576.2 |  |  | 0.43 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001701.4 |  |  | 0.42 | ribosomal | nisin O | Blautia obeum
BGC0000515.4 |  |  | 0.37 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0002328.3 |  |  | 0.37 | ribosomal | Rc-AIP1 | Ruminiclostridium cellulolyticum H10
BGC0000506.4 |  |  | 0.36 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000542.3 |  |  | 0.34 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  |  | 0.34 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000559.4 |  |  | 0.34 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.74 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001701.4 |  | 0.64 | ribosomal | nisin O | Blautia obeum
BGC0000538.3 |  | 0.62 | ribosomal | nisin Z | Lactococcus lactis
BGC0001289.5 |  | 0.59 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000542.3 |  | 0.56 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.56 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000515.4 |  | 0.56 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.4 |  | 0.54 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.54 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000556.5 |  | 0.53 | ribosomal | streptin | Streptococcus pyogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for PGT18_RS05880

PGT18_RS05860
Leader:
MAKFDDFDLDIIEKKVRRDIILASI
Core:
T S Q H S F C T P N C P T G F L C P P K T Q L T C T C K L K G R
Core with dehydrations:
Dhb Dha Q H Dha F Cys Dhb P N Cys P Dhb G F L Cys P P K Dhb Q L Dhb Cys Dhb Cys K L K G R

#### antiSMASH-DB 4.0 matches for PGT18_RS05860

100.0%
NZ_JAQEAZ010000004.1:
Lanthipeptides: PGT18_RS05860_lanthipeptide
1
T S Q H S F C T P N C P T G F L C P P K T Q L T C T C K L K G R
32
T S Q H S F C T P N C P T G F L C P P K T Q L T C T C K L K G R
1
T S Q H S F C T P N C P T G F L C P P K T Q L T C T C K L K G R
32
88.2%
NC_021022.1 and 2 others:
NC_021022.1 Lanthipeptides: CK5_RS17320_lanthipeptide NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10870_lanthipeptide
Lanthipeptides: CK5_RS17320_lanthipeptide
1
T S Q H S F C T P N C P T G F L C P P K T Q L T C T C K L K G R
32
T S Q H S F C T P N C T G F L C P P K T Q L T C T C K L K G+
3
T S Q H S F C T P N C L T G F L C P P K T Q L T C T C K L K G Q
34
51.5%
NZ_JADNJR010000016.1 and 2 others:
NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptide NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide
Lanthipeptides: I2E58_RS10880_lanthipeptide
5
S F C T P N C P T G F L--C P P K T Q L T C T C K L K G R
32
S C T P C P T G L C P K T T C C + G+
5
S A C T P G C P T G I L M T C P L K T A-T C G C H I T G K
33
with 53 more sequence matches
Only the first 10 are displayed here.
51.5%
NZ_QSHK01000002.1 and 1 other:
NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide
Lanthipeptides: DW860_RS04735_lanthipeptide
5
S F C T P N C P T G F L--C P P K T Q L T C T C K L K G R
32
S C T P C P T G L C P K T T C C + G+
5
S V C T P G C P T G I L M T C P L K T A-T C G C H I T G K
33
46.9%
NC_014479.1 and 9 others:
NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptide NZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptide NZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptide NZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptide NZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptide NZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptide NZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptide NZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptide NZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide
Lanthipeptides: BSUW23_RS16845_lanthipeptide
4
H S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
S C T P C T G L C +T L T C C K+
4
E S L C T P G C V T G A L Q T C F L Q T-L T C N C K I
30
46.9%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
2
S Q H S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
+ S C T P C T G L C P K T T C C
2
T S K S L C T P G C K T G A L M T C P I K T A-T C G C H F
30
45.5%
NZ_CP015405.2 and 7 others:
NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide
Lanthipeptides: A4V09_RS08300_lanthipeptide
2
S Q H S F C T P N C P T G F L--C P P K T Q L T C T C K L K G R
32
+ S C T P C T G L C P +T T C C++ G+
2
T S K S L C T P G C V T G I L M T C P V Q T A-T C G C Q I T G K
33
43.8%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
1
T S Q H S F C T P N C P T G F L--C P P K T Q L T C T C
27
+ S C T P C T G L C K T T C C
1
V T S K S L C T P G C K T G I L M T C A I K T A-T C G C
28
43.8%
NC_016047.1 and 2 others:
NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptide NZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide
Lanthipeptides: GYO_RS39160_lanthipeptide
4
H S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
S C T P C T G L C +T +T C C K+
4
E S V C T P G C V T G L L Q T C F L Q T-I T C N C K I
30
43.8%
NZ_CP021903.1 and 20 others:
NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptide NZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptide NZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptide NZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptide NZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptide NZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptide NZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptide NZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptide NZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptide NZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptide NZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptide NZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptide NZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptide NZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptide NZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptide NZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptide NZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide
Lanthipeptides: CD007_RS17065_lanthipeptide
4
H S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
S C T P C T G L C +T +T C C K+
4
E S L C T P G C V T G V L Q T C F L Q T-I T C N C K I
30
43.8%
NZ_CP024974.1 and 1 other:
NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide
Lanthipeptides: CVO91_RS06555_lanthipeptide
5
S F C T P N C P T G F L--C P P K T Q L T C T C
27
S C T P C T G L C K T T C C
5
S L C T P G C K T G I L M T C A I K T A-T C G C
28
41.2%
NC_013656.1 and 20 others:
NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptide NZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptide NZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptide NZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptide NZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptide NZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptide NZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptide NZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptide NZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptide NZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptide NZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptide NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide NZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptide NZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptide NZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptide NZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptide NZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptide NZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptide NZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide
Lanthipeptides: LLKF_RS13210_lanthipeptide
5
S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
S C T P C T G L C K T T C C +
5
S L C T P G C K T G A L M G C N M K T A-T C N C S I
30
41.2%
NZ_CP065984.1 and 2 others:
NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptide NZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide
Lanthipeptides: I6I21_RS02785_lanthipeptide
5
S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
S C T P C T G L C K T T C C +
5
S L C T P G C K T G A L M G C N M K T A-T C H C S I
30

#### MIBiG 4.0 matches for PGT18_RS05860

41.2%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
5
S F C T P N C P T G F L--C P P K T Q L T C T C K L
29
S C T P C T G L C K T T C C +
5
S L C T P G C K T G A L M G C N M K T A-T C H C S I
30
15.6%
BGC0001155.5 (AGY49587.1):
Thiopeptide: GE2270
10
N C P T G F L C
17
N C G F C
3
N C V C G F C C
10
12.5%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
8
T P N C P T
13
T P P T
2
T P A T P T
7
with 1 more sequence matches
10.3%
BGC0001229.4 (SBI_06990)and 1 other:
BGC0002110.3 (QKV49893.1) Lanthipeptide: birimositide
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
C T P N C
11
C P N C
34
C Q P N C
38

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.15 out of 27.78
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
Additional weak hits (2):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.70 out of 27.18
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

PGT18_RS05860 - Class I
  Cleavage pHMM score: -0.20
  RODEO score: 14
  Monoisotopic mass: 3352.7 Da
  Molecular weight: 3354.9 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3373.0 Da N = 1
    3391.0 Da N = 2
    3409.0 Da N = 3

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (0...18966)
PGT18_RS05880
  RRE type: Lanthipeptide_LanB_RRE
  Location: 142 - 228
  Score: 45.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis