LOCUS       NZ_CP115450            21107 bp    DNA     linear   CON 17-DEC-2024
DEFINITION  Kitasatospora cathayae strain HUAS 3-15 chromosome, complete genome.
ACCESSION   NZ_CP115450
VERSION     NZ_CP115450.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora cathayae
  ORGANISM  Kitasatospora cathayae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8860963)
  AUTHORS   Zheng,Y., Mo,P., Li,J., Zhou,Z., Huang,K., Luo,Y., Xie,P. and
            Wang,Y.
  TITLE     Kitasatospora cathayae sp. nov., a novel endophytic actinomycete
            isolated from the leaves of Cathaya argyrophylla
  JOURNAL   Int J Syst Evol Microbiol 74 (5) (2024)
   PUBMED   38809239
REFERENCE   2  (bases 1 to 8860963)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-DEC-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 155.15x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027627435.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 15:42:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,288
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,919
            CDSs (with protein)               :: 7,919
            Genes (RNA)                       :: 113
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 256
            CDSs (without protein)            :: 256
            Pseudo Genes (ambiguous residues) :: 0 of 256
            Pseudo Genes (frameshifted)       :: 79 of 256
            Pseudo Genes (incomplete)         :: 220 of 256
            Pseudo Genes (internal stop)      :: 9 of 256
            Pseudo Genes (multiple problems)  :: 51 of 256
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:37:27
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6196944
            Orig. end                         :: 6218051
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP115450.1.
            Bacteria and source DNA available from Mo Ping.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21107
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="23"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21107
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21107
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11107](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11107)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            220..1554
                     /locus_tag="O1G21_RS27720"
                     /old_locus_tag="O1G21_27720"
     CDS             220..1554
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135297.1"
                     /locus_tag="O1G21_RS27720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27720"
                     /product="class II 3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_270147468.1"
                     /transl_table=11
                     /translation="MTVTNLHTWQSLPAAQQPEWPDQEALRKTLAELSSYPPLVFAGEC
                     DQLRARLGAVARGEAFLLQGGDCAEAFDGVSAEHIRNKLKTLLQMAAVLTYAASVPVVK
                     VGRIAGQYSKPRSKSTETRDGVTLPVYRGDSVNGFEFTPESRIPDPERLKRMYNASAAT
                     LNLVRAFTTGGYADLRQVHAWNQDFVRNSPAGQRYEQLAREIDNALAFMNACGVAPEEF
                     KTVEFFSSHEALILDYETALTRVDSRTGDLYDVSGHMVWIGERTRQLDHAHIEFASKIR
                     NPIGVKLGPTTSVDEALTLIEKLDPEREPGRLTFITRMGAGKIRDHLPTLVEKVTASGA
                     QPVWICDPMHGNTFEASSGHKTRRFDDVLDEVKGFFEVHRALGTHPGGIHVELTGDDVT
                     ECVGGGDEVLVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRGQ"
     misc_feature    complement(1681..1699)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.08"
                     /tool="antismash"
     misc_feature    complement(1701..1719)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     misc_feature    complement(1712..1725)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            1730..2065
                     /locus_tag="O1G21_RS27725"
                     /old_locus_tag="O1G21_27725"
     CDS             1730..2065
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_BFD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557078.1"
                     /locus_tag="O1G21_RS27725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27725"
                     /product="bacterioferritin-associated ferredoxin"
                     /protein_id="WP_405000718.1"
                     /sec_met_domain="Fer2_BFD (E-value: 1.1e-13, bitscore:
                     50.2, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFTPGETAMYVCMCHAVTEDQVKKAIDGGAGTPRQIAKGCKAGT
                     DCGSCVRRIQALLGEHGARPCPTARLAAKLGLADPEVQDVPAPAAPKPVPTAPAGPIAP
                     VVPLRVA"
     gene            complement(2099..2578)
                     /gene="bfr"
                     /locus_tag="O1G21_RS27730"
                     /old_locus_tag="O1G21_27730"
     CDS             complement(2099..2578)
                     /EC_number="1.16.3.1"
                     /GO_function="GO:0004322 - ferroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008199 - ferric iron binding [Evidence
                     IEA]"
                     /GO_process="GO:0006879 - intracellular iron ion
                     homeostasis [Evidence IEA]"
                     /GO_process="GO:0006880 - intracellular sequestering of
                     iron ion [Evidence IEA]"
                     /codon_start=1
                     /gene="bfr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478270.1"
                     /locus_tag="O1G21_RS27730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27730"
                     /product="bacterioferritin"
                     /protein_id="WP_270147470.1"
                     /transl_table=11
                     /translation="MQGDPEVIEFLNEQLTAELTAINQYFLHAKMQENFGWTKLAKYTR
                     HESFDEMKHAETLTDRILFLEGLPNYQRLFHVRIGQTVKEMFEADRQIEVEAIDRLKRG
                     IVVMRAKNDVTSANIFEDILADEEHHIDYLDTQLELLDKLGEALYLAQQIEQPES"
     misc_feature    2648..2662
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.63"
                     /tool="antismash"
     gene            2810..3439
                     /locus_tag="O1G21_RS27735"
                     /old_locus_tag="O1G21_27735"
     CDS             2810..3439
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135294.1"
                     /locus_tag="O1G21_RS27735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27735"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_270147471.1"
                     /transl_table=11
                     /translation="MGQSEQEPLPPSDPRLPPGQRAQRGWPALHYGPVPRFKPLSWDLQ
                     VFGATASAEKHSWDFAAFNALPRTTVVADLHCVTKFSLLGNEWTGVPAALLLDLVPPAP
                     GVTHVMVWAEYGYSANLRLADFADRRTLLATHRNGEALTAEHGFPVRLVVPGLYAWKGP
                     KWVRAVEYMRADRRGFWEERGYHNLADPWREQRYSYQEEPGDGPLR"
     gene            complement(3453..5228)
                     /gene="pknB"
                     /locus_tag="O1G21_RS27740"
                     /old_locus_tag="O1G21_27740"
     CDS             complement(3453..5228)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF033483.0"
                     /locus_tag="O1G21_RS27740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27740"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_270147473.1"
                     /sec_met_domain="Pkinase (E-value: 2.7e-48, bitscore:
                     163.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKALHDPLIGTLLDNRYRVEQRIATGGMSTVYKGTDTRLDRVVA
                     LKVMHPQLAGDEGFTARFIREAKAVAKLTHPNVVNVFDQGADGGNVFLAMEYVPGRTLR
                     DLLRDRGALSVRAALDVLEPVLAALGAAHRAGLVHRDVKPENVLITESGLVKVADFGLV
                     RVLGSADGAPTSTTTATGGTVMGTVSYLAPEQILPDAPTDQRVDVYAAGILLYEMLTGR
                     RPHTGDNPVQVMYKHLHEDVPAPSLTAPTVAPALDAIVAGACARAVDARPYDAVELLAA
                     LQRVRRTLTPAELDAEPPASTRPSPRYPTSEPTSVIQPLPRPADAPPAERTSVLDLPAE
                     LMDQLLAEPRPYDEPTPVRVRRPRRVPRKPLIWAAALTALVLAVGGATYGISAGLYGSV
                     PGVLGKDRGEAQRMLDQEGMHGRFVEAFSESVPAGQVISTDPGVGARTRKSDSVTITVS
                     KGPKRIAVPDVTGKSADDAAAALAGAQLTRGGVTQTYNDTVPDGSVISSSPAAGQMLPE
                     NAAVALVVSKGMVPVPDVSGMSRDDAQRALQAAGFTMKAATDWTLGMGKVSGQSPAAGE
                     RRPQKTVVTVNFSLF"
     misc_feature    complement(5281..5296)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(5302..6108)
                     /locus_tag="O1G21_RS27745"
                     /old_locus_tag="O1G21_27745"
     CDS             complement(5302..6108)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004946614.1"
                     /locus_tag="O1G21_RS27745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27745"
                     /product="thiazole synthase"
                     /protein_id="WP_270147475.1"
                     /transl_table=11
                     /translation="MADDLLSIAGTTFSSRLIMGTGGAPSLEVLERALLASGTELTTVA
                     MRRVDATTQGSVLDVLTRNGIGVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIAD
                     ERTLLPDPIELLDAAETLVDDGFTVLPYTNDDPVLARKLEEVGCAAIMPLGSPIGSGLG
                     IRNPHNFQLIVEGAGVPVILDAGAGTASDVALAMELGCSAVMLASAVTRAQDPVLMAEA
                     MRHAAEAGRLAHRAGRIPRRFHAEASSAMAGRADLDTRERPAFQSV"
     gene            complement(6112..6351)
                     /gene="thiS"
                     /locus_tag="O1G21_RS27750"
                     /old_locus_tag="O1G21_27750"
     CDS             complement(6112..6351)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557085.1"
                     /locus_tag="O1G21_RS27750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27750"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_270147478.1"
                     /transl_table=11
                     /translation="MTETSPTDTAPAEIALSVNGEPRRVPAATTLAELVATVSPANTGV
                     AAALNEAVVPRSSWPATALNGGDRVEILTAVQGG"
     gene            complement(6348..7532)
                     /gene="thiO"
                     /locus_tag="O1G21_RS27755"
                     /old_locus_tag="O1G21_27755"
     CDS             complement(6348..7532)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015032971.1"
                     /locus_tag="O1G21_RS27755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27755"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_405000719.1"
                     /sec_met_domain="DAO (E-value: 4e-71, bitscore: 239.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLPSGNRADVLVIGGGVIGLAVAWRAAQRGLRNVIVVDPCHGG
                     GAAGVAAGMLAPVTELQYGEEPLLHLGMASNQRYESFAAELTEASGGLDTGYRRCGTIA
                     VALDSDDREELRELHAFHQRLGLDSSWLTGREARKLEPMLAPGVRGGLHVADDHQVDPR
                     RLLTALVTACERAGVLLHRAEAVELLVDGDRATGARLSTHETVTADRIVLAAGPHSHRL
                     PGLPEGALPAIRPVKGQVLRLQIPDAYRPFLSRNVRAVVRGQHLYLVPRENGELVVGAT
                     TEEQGYDTTVTAGGVYELLRDAHELVPGITELPLAETAAGLRPGSPDNAPLLGPTSLPG
                     LVAATGHYRNGVLLTPVTADLLADYLANGEVPELAKPFTPTRFLPDAPTTKASA"
     regulatory      complement(7527..7639)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    7557..7570
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            7723..8925
                     /locus_tag="O1G21_RS27760"
                     /old_locus_tag="O1G21_27760"
     CDS             7723..8925
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135288.1"
                     /locus_tag="O1G21_RS27760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27760"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_270147480.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-57, bitscore:
                     194.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGVAELNGTDQVVVVGAGLGGAQCALKLRQGGWRGRIVLVGEER
                     HAPYDRPPLSKDVLLGKTDATTLDIDYAGLGIELLTGRRATGLTPGVLHTDGGDLPYDS
                     LVIATGATPRALPGAERAHLLHTLDDALALRALLRPGLRLVLVGAGWIGAEVSTAARQA
                     GCEVTVVEAGPAPLPGALPTEVGSAMAAWYAEAGVELRCGVGVAAVEAGAVLLADGSHL
                     PADEVVVGVGARPATGWLAGSGVELDASGAVVVDGRLRTGLPGVFAAGDCVSYPSARSG
                     ARLAVQHWDHALQSGEAAAAAVLGADAPYDPVPYFWSEQFGRMVQYLGRHAEGDELLWR
                     GSPRDAAWSVLWLRDGVPSALLAVDRPRDLTQGRKLIERGTPLDRTLAADPSVALKGAT
                     A"
     gene            8959..9324
                     /locus_tag="O1G21_RS27765"
                     /old_locus_tag="O1G21_27765"
     CDS             8959..9324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129955.1"
                     /locus_tag="O1G21_RS27765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27765"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_270147482.1"
                     /transl_table=11
                     /translation="MSEIDAKTDALVPEWLYLPDISERWGVLVTEVRNMVKKGDLIAVR
                     RGPNKSLQVPAAFIDETGPVKHLVGLLTVLRDSGFTDQEIVEWMFTEDPTLPGTPVQAL
                     WENRATEVKRRAQAMAL"
     gene            9324..9968
                     /gene="thiE"
                     /locus_tag="O1G21_RS27770"
                     /old_locus_tag="O1G21_27770"
     CDS             9324..9968
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976712.1"
                     /locus_tag="O1G21_RS27770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27770"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_270147483.1"
                     /transl_table=11
                     /translation="MTDLRSRLADARLYLCTDARREQGDLAEFLDAALAGGVDIVQLRD
                     KGLEAKQELAALEVFADACRRHGKLLSVNDRADVAHAARPDVLHLGQDDLPVPAARAIL
                     GEDVLIGRSCHAESEVDAAIAEPGVDYFCTGPVWPTPTKPGRPAPGLGLVSYTAEQATD
                     RPWFAIGGIDLGNVDEVLAAGARRIVVVRAITAAEDPRAAAAELARRVRAV"
     gene            complement(10001..11107)
                     /locus_tag="O1G21_RS27775"
                     /old_locus_tag="O1G21_27775"
     CDS             complement(10001..11107)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135284.1"
                     /locus_tag="O1G21_RS27775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27775"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_270147484.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.1e-43, bitscore:
                     145.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSSNRPANPIDVEDVRTRVNAALAAFMDDQSALLGKISPQLVP
                     AADALRDFLLDGGKRLRPAFCYWGWRAAGGAAGGEGIANAAAALELLQASALVHDDLMD
                     RSDTRRGLPSIHRRFEALHRDSGWRGDREQYGASAAVLLGDLLLIWCDELFLRSGLDPA
                     AVLGAKPVFDLMRTEVMLGQYLDVLEPVAGDSADEGALERARTVLHYKSAKYTIERPLQ
                     VGALLAGAGPELVEALGAFGLPLGEAFQLRDDLLGVFGDPAVTGKPAGDDLREGKRTLL
                     VAHAMRALPQADARHLDARLGAPDLAVEEVAGLRELVARSGAPELVERRIDELMGQSLA
                     ALAAAPLADEQARTVLLALAEAATVRKY"
     misc_feature    complement(11159..11174)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.03"
                     /tool="antismash"
     gene            11283..12200
                     /gene="metF"
                     /locus_tag="O1G21_RS27780"
                     /old_locus_tag="O1G21_27780"
     CDS             11283..12200
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837690.1"
                     /locus_tag="O1G21_RS27780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27780"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_270147485.1"
                     /transl_table=11
                     /translation="MALGIASTRSDRALTVRELLAAGKRSFSFEFMPPRTEVGEQRLWD
                     AIRRLEPLDPNFVCMTYGAGGSSRERTVNMVGRIATETTLTPVAHLTAVDHSVAELRNI
                     IGQYADQGVRNVLAVRGDPPGDPMGEWVRHPDGVTYAYELVELIKGIGDFCVGVAASPN
                     MHPRSADWDEDIRHFIAKVRSGADYAITQMFFEVDDYLRFRDRVTAAGCETPIIPEIMP
                     VTNAKQLERFPQLSGSAFPADLEARLRAAVDDPAALRAVGMEHATAMAERLLAEGAPGL
                     HFITLNHSTATLEIYQNLGLHQRS"
     gene            12364..13224
                     /locus_tag="O1G21_RS27785"
                     /old_locus_tag="O1G21_27785"
     CDS             12364..13224
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS27785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_27785"
                     /product="hypothetical protein"
                     /protein_id="WP_270147487.1"
                     /transl_table=11
                     /translation="MGIGYLLLYVALAVVALWLIAEVLVQNRAPLHWRVLALAGFLGVV
                     VGMGLGSVVVIGAGAGLFAVGQAFVTLSVKKGYQAGWSLRKADGGLPGPLAKVPLLGAL
                     TSGAAVAAAGTAEEKRVGEVSAVEETPVASAAPVPAAEEEPEVERTAPFEMQELAQDGV
                     YAPAYYEQQQAPPQQDPYAPAYQSGYDQQQWQTQQQPAYAYDQQQSYGGYPQQQDPYGG
                     YQQQDPYAGYPQPAWDPNAQQQHQQHQQQWQPQPEQHGQGIPQQPAYDQSGYGHQQQNT
                     WPSHG"
     gene            13340..13735
                     /locus_tag="O1G21_RS27790"
                     /old_locus_tag="O1G21_27790"
     CDS             13340..13735
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS27790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_27790"
                     /product="hypothetical protein"
                     /protein_id="WP_270147489.1"
                     /transl_table=11
                     /translation="MDPISTAALAGATLAATAALQSVGEEAGRSSWTVASRLVERIRHR
                     FAGNHEAEGALARACDSPDDEAAVGELHRVLHEYMLRDSEFAQEVRRLVDESVRSAGGV
                     GGINAAVIKNVQVNHGKVEVAGDLNFS"
     gene            13806..16073
                     /locus_tag="O1G21_RS27795"
                     /old_locus_tag="O1G21_27795"
     CDS             13806..16073
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535568.1"
                     /locus_tag="O1G21_RS27795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27795"
                     /product="hypothetical protein"
                     /protein_id="WP_270147491.1"
                     /transl_table=11
                     /translation="MSDEATASHAERGGADPAVGDRSVPAGDATAEKHPAPSGTADEGE
                     GPLNEAAALVALSKGADDPQEWADAARVAQIADLIAHRLRDDPSGLRIGTLALFQDTVS
                     FGGGFNVHGHAAERTGVPASAGGSLARIEPDEQNGHLACYVRPHGYKSALELLQECHLI
                     VLAQPPGTGRAAAAVNLLVEALIDAGAADGGSCYRSTDPSAVLSATWTPPHQNAGYLVE
                     LDDRSARGSTVYDAVDSGWLTAAASALKARNSFMVVITGPPRGVLAWAADRTPYVFSDL
                     GAIDATEVLERHVLGPAPDEAELRDLRARLARSGAAEALREQPEPAIAVALARTVRARR
                     DLAEQVALLRDPSEQVRQWFSRHEDLEALCFAVSAAVLEGSSYLTVSDAAIQLHTALVR
                     DPYTLTGLRYRDRLGHDQPWITVSGAADDGTARPFGPPKVSFRSPLVRQAVLAHAWSYL
                     DGMRNELLAWLRRLLVHSDVEVRARAAVAAGVMAWSDHEHALHRYLSSWSSSTVWPVRQ
                     AAATALGVIGGQPGLTEAVWGRLDRWAVEGTSAAARRQAKTAATAAGGLLGRDAPDRAL
                     AVLRIALAWKDDWGNLVPVAWSVVRLNDQGRADAVLAALLEWSKAQDLSPMVAKSLSVF
                     LFSAERTHPATAGEADRPSVLWTRVGELGRPLEELWARALARKPIQEQALATLRTWLTD
                     YAERDPRRLPVVRELLIGIARRPGKHRERLVYWLGVWSADRERPCRAAASLREAVVAAT
                     SR"
     gene            16114..17274
                     /locus_tag="O1G21_RS27800"
                     /old_locus_tag="O1G21_27800"
     CDS             16114..17274
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS27800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_27800"
                     /product="hypothetical protein"
                     /protein_id="WP_270147492.1"
                     /transl_table=11
                     /translation="MDSSTYDPVLAQERLAWLRLLNPLRSPEPGRALVLVPNDGPALTV
                     RPGEEISDAWVGRYQTAYTVDTTEHRLVLEIPLLSRDPTFAFRSEVALVCAVVDPAEVV
                     ARGIRDMSDALFDHMRRMLRAVSRDYDIAEFHEAEAALNRRVRDFTGDTAVRLRNIHVE
                     LLVDEDEVAISGRTYRDVVRETRLAGMRRQRHLDMLRADGFEGLIAEIMEREGPRAAQE
                     LIAKAEAEEREELMRTFKLVLERGDADREPFEVANTERMVLGRLLGGSEAPFGGTRASR
                     VRGGMADRAVEDRSRGWAEDRPATVLPGEVVPPSITGPPDDEPLADKVPLDKAPTGADG
                     GYGVRRPGPGPGPDRRTGARAGEAEQPRASRVRGVQRVRPADGGGR"
     gene            17271..18362
                     /locus_tag="O1G21_RS27805"
                     /old_locus_tag="O1G21_27805"
     CDS             17271..18362
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535567.1"
                     /locus_tag="O1G21_RS27805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27805"
                     /product="PP2C family serine/threonine-protein phosphatase"
                     /protein_id="WP_270147493.1"
                     /transl_table=11
                     /translation="MTTPPRAVPPAPSVPPVPSGPAMPPEAPTTAVTHAVGLDPQAGLG
                     ALSVWTERTAGAGEDADPLVLHHLPSRTGLVAVFDGAGGAGSGPSWTNGRGLSRSGAWT
                     GSRVARLAVELWFRDCVEHHRPPEARVLEDRLREVLDAARPAVRSKVVGTMRRQLPTTM
                     AAIRYRIGDTGVSVRTLWAGDSRAYVLTPSEGLQVLTRDHTDETDALAQLIQDPPMTNM
                     VCADRPFRVESHAVPLNGPCVLLCATDGFFGYLWTPGDFESVLLESLQKSSDEADWAAR
                     LSRKVEQYTADDASLALVTIGFSDFRELCERFRDRYRRSRERYRGMPDFSDAQALRHWR
                     EQDWLRYRTEYERHMPEAGEVAE"
     gene            18359..19501
                     /locus_tag="O1G21_RS27810"
                     /old_locus_tag="O1G21_27810"
     CDS             18359..19501
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603470.1"
                     /locus_tag="O1G21_RS27810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27810"
                     /product="protein kinase domain-containing protein"
                     /protein_id="WP_270147494.1"
                     /sec_met_domain="Pkinase (E-value: 3.3e-20, bitscore: 71.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLGEEINGYRITTTPTNNNGGKCVWAFAEKDGRPYFIKQFLEPK
                     RPRPDSPGSERSKRIRQEVCREFEERHRGVMSRLTPDMRGGGNLVLAEDFFADGSTYYK
                     VTARIDTSTLERPQTLEPRQKSVLLRTLAVSLQLLHGIGIVHGDLKPANVLVQENKDNS
                     LHIAKLIDFDDSYLSGSPPGPHDIAGDSLYGAPEWRRYVQEDPAVDARMLTTAADMFAL
                     GLMAHYYLTGALPGYDARYGSPADAVNAGEELRLDPRLSATVKGLITALTGRAPESRPR
                     IAAFLAALKDPEACALRHPRPGTAKPSPAAAPAPAASGPVPQGSAEARVSRLRMNLGGG
                     PRGRAATEPESTPPTSPDSPAAETPPRVSRVRINLGDRRK"
     misc_feature    19518..19533
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.29"
                     /tool="antismash"
     misc_feature    19519..19532
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     gene            19560..20267
                     /locus_tag="O1G21_RS27815"
                     /old_locus_tag="O1G21_27815"
     CDS             19560..20267
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603471.1"
                     /locus_tag="O1G21_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_27815"
                     /product="vWA domain-containing protein"
                     /protein_id="WP_270147495.1"
                     /transl_table=11
                     /translation="MSTAQTPYQGNLQYAVDIVLCVDATASMGPVLESVKASALSFHQR
                     LESVMASKGKSISQLRIKTIAFRDFGDRADDALEETDFIQLPDGAHEFEGFLKGLEATG
                     GGDIPESALEALALAVGAPWETGLDRRRHVIVMFTDAPAHPLGSTHTTVPGYPQSIPRS
                     MDDLFEQWGYARSQAAVMEQSAKRLVLFAPDQQPWTGIADDWDLTLHFPSKAGDGLQEF
                     EMDEIIDTIANSL"
     gene            20275..20703
                     /locus_tag="O1G21_RS27820"
                     /old_locus_tag="O1G21_27820"
     CDS             20275..20703
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS27820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_27820"
                     /product="hypothetical protein"
                     /protein_id="WP_270147496.1"
                     /transl_table=11
                     /translation="MGSLPTMRLRCVGADLVHRNDWLNLIWDAGGELHLPLDSCTRLDT
                     RRIEEDGCTQIVLSFAPLTECGTRGAGWINVRLEVTAEHNADAHEFLQFVRRWTAEEGA
                     AAVPRRSGEEDWISFPPADEARELYEQVLQRTGGHRPL"
     misc_feature    20280..20294
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
ORIGIN
        1 cgccccgagg ggcggccgtc gtgttcgtct aggaacgcgc gatctgtggg ccacccgtgg
       61 gggaggccca ccaccagcag tgggtgtggg gcgcgtgcat gggtcgagcg tagccgatgc
      121 ggccgggcgg gtgagccccg acgcggaatg tgtccggaag gtgtctcacc actcgggcaa
      181 tggtcacgga tcacctgcgt caccccgtag ccttgccgtg tgaccgtgac gaacctccac
      241 acctggcagt ccctgcccgc ggcgcagcag cctgaatggc cggaccaaga ggctctgcgc
      301 aagacccttg ccgagctctc ctcctatccg cccctcgtct tcgccggcga gtgtgaccag
      361 ctgcgcgccc ggctcggtgc cgtggcgcgt ggggaggcgt tcctcctgca gggcggcgac
      421 tgcgccgagg ccttcgacgg cgtgtcggcg gagcacatcc gcaacaagct gaagaccctg
      481 ctgcagatgg cggccgtgct gacgtacgcc gcctcggtgc cggtcgtgaa ggtcggccgg
      541 atcgccggcc agtactccaa gccgcgctcg aagtcgaccg agacccggga cggcgtgacc
      601 ctgccggtct accgaggcga ctcggtgaac ggtttcgagt tcacccccga gtcccggatc
      661 ccggacccgg agcgcctgaa gcggatgtac aacgcctccg ccgcgacgct gaacctggtg
      721 cgtgccttca ccaccggtgg ttacgccgac ctgcgccagg tgcacgcctg gaaccaggac
      781 ttcgtgcgca actcgccggc cggccagcgc tacgagcagc tcgcccggga gatcgacaac
      841 gccctggcgt tcatgaacgc ctgtggcgtg gcgccggagg agttcaagac cgtcgagttc
      901 ttctcctcgc acgaggcgct gatcctcgac tacgagaccg cgctgacccg cgtggactcg
      961 cgcaccggcg acctgtacga cgtctccggc cacatggtgt ggatcggtga gcgcacccgg
     1021 cagctggacc acgcgcacat cgagttcgcc tccaagatcc gcaacccgat cggggtcaag
     1081 ctgggcccga ccacctcggt ggacgaggcg ctcaccctga tcgagaagct ggacccggag
     1141 cgcgagcccg gtcgtctgac cttcatcacc cggatgggcg cgggcaagat ccgcgaccac
     1201 ctgcccaccc tggtggagaa ggtcaccgcc tccggcgccc agccggtgtg gatctgcgac
     1261 ccgatgcacg gcaacacctt cgaggcctcc agcggtcaca agacccgccg cttcgacgac
     1321 gtgctggacg aggtcaaggg cttcttcgag gtccaccgcg cgctcggcac ccacccgggc
     1381 ggcatccacg tggagctgac cggcgacgac gtcaccgagt gcgtcggcgg cggtgacgag
     1441 gtgctggtcg acgaccttca ccagcgctac gagacggcct gcgacccgcg gctcaaccgc
     1501 agccagtcgc tggacctggc gttcctggtg gcggagatgt accggggcca gtgatccacc
     1561 ggcctcccgc cccgaccctt cggctcgggg cgggcgagcg ggcgagtgac tgtgacgaag
     1621 gtccctccgg attcgggatt cccgagcccg gaggggcttt ttcgtgcccg gatcgccagg
     1681 taaggtgagg cttagtgaac taaggcaagc cttagtcaag atccactccg tgcgcttcac
     1741 cccgggagag accgcgatgt acgtttgcat gtgccatgcg gtcaccgagg accaggtgaa
     1801 gaaggcgatc gacgggggtg ccggcactcc gcgccagata gccaagggct gcaaggccgg
     1861 cacggactgc gggtcctgcg tccgccggat ccaggcgctg ctcggcgagc acggcgcccg
     1921 gccctgcccg accgcccggc tggccgcgaa gctcggcctc gccgacccgg aggtccagga
     1981 cgttcccgcg ccggccgccc cgaagccggt cccgacggca ccggcgggcc cgatcgcgcc
     2041 ggtggtcccg ctgcgggtgg cctgagcgct gcggtggcct gagccgggag gcgttcggct
     2101 aggactccgg ctgctcgatc tgctgggcga ggtagagcgc ctcgccgagc ttgtccagga
     2161 gttccagctg ggtgtcgagg tagtcgatgt ggtgctcctc gtcggccagg atgtcctcga
     2221 agatgttcgc cgaggtgacg tcgttcttgg cccgcatcac cacgatcccg cgcttgagcc
     2281 ggtcgatcgc ctcgacctcg atctggcggt ccgcctcgaa catctccttg accgtctggc
     2341 cgatccggac gtggaacagc cgctggtagt tgggcagccc ctccaggaac aggatccggt
     2401 cggtgagcgt ctcggcgtgc ttcatctcgt cgaaggactc gtgccgggtg tacttggcga
     2461 gcttcgtcca gccgaagttc tcctgcatct tggcgtgcag gaagtactgg ttgatcgcgg
     2521 tgagctcggc cgtgagctgc tcgttgagga actcgatgac ctccgggtcg ccctgcatgg
     2581 tgctgcctcc ctgcgctacg tcctgcggtg agtcctgcgc tgggcatcct ggcaccgtat
     2641 cgggaggaaa ttccagtaag ttcacactca ctaggacatg tggcggaata tccgatttgg
     2701 gcggtgatcg cggggtgtgc gatcgacctt tggcccgtac gggcagggcg tgaagcgcgg
     2761 gccaaggggc gcgcgccgtg gctcgtccgc cgtctgtcac catggagcca tgggtcagtc
     2821 cgaacaagaa ccgcttccgc cgtctgaccc gaggctcccc ccgggtcagc gcgcgcagcg
     2881 cggctggccc gccctgcact acgggccggt gccccgcttc aagccgctga gctgggacct
     2941 ccaggtgttc ggcgccaccg cctcggcgga gaagcacagc tgggacttcg cggccttcaa
     3001 cgccctgccg cgcaccaccg tggtcgccga cctgcactgc gtcaccaagt tctccctgct
     3061 cggcaacgag tggacgggcg tgcccgcggc cctcctgctc gacctggtgc ccccggcgcc
     3121 cggcgtcacc cacgtcatgg tctgggccga gtacggctac agcgccaacc tgcggctggc
     3181 cgacttcgcc gaccggcgca ccctgctggc cacccaccgc aacggcgagg cgctgaccgc
     3241 cgagcacggc ttcccggtcc ggctggtggt cccggggctg tacgcctgga agggccccaa
     3301 gtgggtgcgc gcggtggagt acatgcgggc cgaccggcgc ggcttctggg aggagcgcgg
     3361 ctaccacaac ctggccgacc cctggcgcga acagcgctac tcctaccagg aggagccggg
     3421 cgacgggccg ctccgctgag ccccgaaatc ccctagaaca gcgagaagtt gaccgtcacc
     3481 acggtcttct gcggccgccg ctcgccggcc gccggggact ggccgctcac cttacccatg
     3541 cccagcgtcc agtcggtggc ggccttcatg gtgaagcccg ccgcctgcag cgccctctgc
     3601 gcgtcgtccc ggctcatccc gctgacgtcc gggaccggca ccatgccctt gctgaccacc
     3661 agcgcgaccg cggcgttctc cggcagcatc tgcccggcgg ccggcgagct gctgatcacc
     3721 gaaccgtccg gcacggtgtc gttgtaggtc tgggtcacgc cgcccctggt cagctgggcg
     3781 ccggcgagcg cggcggccgc gtcgtccgcg ctcttgccgg tgacgtccgg caccgcgatc
     3841 cgcttggggc ccttggagac ggtgatcgtc accgagtcgc tcttgcgggt gcgcgcgccc
     3901 accccggggt cggtggagat cacctgcccg gccgggacgg actcgctgaa cgcctcgacg
     3961 aaccggccgt gcatgccctc ctggtccagc atccgctgcg cctcgccgcg gtccttgccg
     4021 agcacccccg gcaccgagcc gtagagcccc gcggagatgc cgtaggtcgc gccgccgacc
     4081 gccagcacca gggcggtcag cgcggccgcc cagatcagcg gcttgcgcgg gacgcggcgc
     4141 ggccggcgca cccggaccgg ggtgggctcg tcgtacgggc ggggctcggc gagcagctgg
     4201 tccatcagct ccgccggcag gtccagcacg ctggtgcgct ccgccggcgg ggcgtcggcg
     4261 ggccggggca gcggctggat caccgaggtc ggctcgctgg tcgggtagcg cgggcttggc
     4321 cgggtggagg ccggcggctc ggcgtccagc tcggcggggg tgagcgtgcg gcggacccgc
     4381 tggagggcgg cgagcagctc caccgcgtcg tacgggcggg cgtcgacggc ccgggcgcag
     4441 gcgccggcca ctatggcgtc cagtgccggg gcgacggtgg gggcggtcag cgagggggcg
     4501 gggacgtcct cgtgcaggtg cttgtacatc acctggacgg ggttgtcgcc ggtgtgcggg
     4561 cggcggccgg tgagcatctc gtacagcagg atgccggccg cgtagacgtc gacccgctgg
     4621 tcggtggggg cgtccgggag gatctgctcg ggggccaggt aggagaccgt gcccatgacg
     4681 gtgccgccgg tggcggtggt ggtcgaggtg ggcgcgccgt cggcgctgcc gagcacccgg
     4741 accaggccga agtcggcgac cttgaccagg ccgctctcgg tgatcagcac gttctccggc
     4801 ttgacgtccc ggtggaccag cccggcccgg tgggcggcgc cgagggcggc gagcaccggc
     4861 tccagcacgt ccagcgcggc ccggacggac agcgcgccgc ggtcgcgcag caggtcgcgc
     4921 agggtgcggc cgggcacgta ctccatggcg aggaaaacgt ttccgccgtc cgcaccctgg
     4981 tcgaagacgt tgaccacgtt ggggtgggtg agcttggcga ccgccttggc ctcgcggatg
     5041 aagcgggcgg tgaagccctc gtccccggcc agctggggat gcatcacctt gagggcgacc
     5101 acccggtcca gccgggtgtc ggtgcccttg tagacggtgg acatcccgcc ggtcgcgatg
     5161 cgctgctcga cccggtaccg gttgtcgagc agggtcccga tcagcgggtc gtgcaatgcc
     5221 ttgtccaccc gcaggagtct agtggggcgg gcggacgccg gtcccggcgg acaccgctcc
     5281 gggaccggct tgtgacacgg cctacacgga ctggaaggcg ggccgctccc gggtgtccag
     5341 gtcggcccgg ccggccatcg cggaggaggc ctcggcgtgg aagcggcgcg ggatgcgccc
     5401 ggcccggtgg gcgagccggc ccgcctcggc ggcgtgccgc atcgcctcgg ccatcagcac
     5461 cgggtcctga gcccgggtca ccgcggaggc gagcatcacc gccgagcagc ccagctccat
     5521 cgccagcgcg acgtcggagg cggtgccggc gcccgcgtcc aggatcaccg ggacaccggc
     5581 gccctccacg atcagctgga agttgtgcgg gttgcggatg cccaggccgg agccgatcgg
     5641 cgagcccagc ggcatgatgg ccgcgcagcc gacctcctcc agcttgcggg ccagcaccgg
     5701 gtcgtcgttg gtgtacggga gcaccgtgaa gccgtcgtcg accaaggtct cggcggcgtc
     5761 cagcagttcg atcgggtccg gcagcagggt gcgctcgtcg gcgatcacct cgagcttcac
     5821 ccagtcggtg ccgagcgcct cgcgggccag tcgggcggtc agcacggcct cgccggcggt
     5881 gaagcagccg gccgtgttgg gcaggacacc gatgccgttg cgggtcagca cgtccaggac
     5941 ggagccctgg gtggtggcgt cgacccggcg catggccacg gtggtcaact cggtgccgga
     6001 ggcgagcagg gcgcgctcca gcacctccag gctcggcgca ccgccggtgc ccatgatcag
     6061 ccgggaggag aaggtcgtcc cggcgatgct cagaaggtcg tcggccatgg ttcagcctcc
     6121 ctggacggcg gtgaggatct cgacccggtc gccgccgttc agcgccgtcg cgggccacga
     6181 actgcgcggc accacggcct cgttgagggc ggcggcgacg ccggtgttgg cggggctgac
     6241 ggtggccacc agctcggcga gggtggtggc ggcgggcacc cggcggggct cgccgttgac
     6301 gctcagggcg atctcggccg gggcggtgtc ggtcgggctg gtctcggtca tgcggaggcc
     6361 ttcgtggtgg gggcgtcggg gaggaatcgg gtgggcgtga acggctttgc cagctcgggg
     6421 acttcgccgt tcgccaggta gtcggcgagc aggtcggcgg tcaccggcgt gagcagcacg
     6481 ccgttgcggt agtggccggt ggcggcgacc agcccgggca gcgaggtcgg gcccagcaac
     6541 ggggcgttgt ccggcgagcc cgggcgcagt ccggccgccg tctcggcgag cgggagttcg
     6601 gtgatgcccg ggaccaactc atgggcgtca cgcaggagtt cgtacacccc gccggcggtg
     6661 acggtggtgt cgtagccctg ctcctcggtg gtcgcgccga ccaccagctc accgttctcc
     6721 cggggcacca ggtacaggtg ctggccgcgc accaccgcgc ggacgttgcg ggacaggaac
     6781 ggccggtagg cgtccgggat ttggaggcgc agcacctgcc ccttcaccgg gcggatggcg
     6841 ggcagcgcgc cctcgggcag gccgggcagc cggtggctgt gcgggccggc ggcgagcacg
     6901 atccggtcgg cggtcacggt ctcgtgggtg ctcagccggg cgccggtcgc gcggtcgccg
     6961 tcgaccagca gctcgacggc ctcggcccgg tgcagcagga cgccggcccg ctcgcaggcg
     7021 gtgaccaggg cggtgagcag ccggcgcgga tccacctggt ggtcgtccgc gacgtgcagg
     7081 ccgccgcgca cgccgggggc gagcatcggc tccagcttgc gggcctcccg gccggtcagc
     7141 cagctggagt ccaggcccag ccgctggtgg aaggcgtgca gttcgcgcag ttcctcgcgg
     7201 tcgtcggagt ccagcgcgac ggcgatggtg ccgcagcggc ggtagccggt gtcgaggcca
     7261 ccgctggcct cggtgagctc ggcggcgaag ctctcgtacc gctggttgga ggccatcccg
     7321 aggtgcagca gcggctcctc gccgtactgc agctcggtga ccggggcgag catcccggcc
     7381 gcgaccccgg ccgcgccccc gccgtggcag gggtcgacca cgatcacgtt ccgcagcccg
     7441 cgctgtgcgg cgcgccaggc gacggcgagg ccgatgacgc ccccgccgat caccagcacg
     7501 tcggcgcggt tgcccgatgg caagcgtgac aaagctgctc ttctcccttc gccggtatga
     7561 cccggatcag gttcggacgg tcgcgggccg tgccagcccg cctctcagcc cggttcgccg
     7621 ggctcccgtg tggtgccccc accttaacgc cgggggtcgg cccggccgaa gggcccgacg
     7681 aggagtggac ggccgccggg gcccgtggca ccgctgagta cagtgacggg cgtggcagag
     7741 ctgaacggaa cggaccaggt ggtcgtcgtc ggagccgggc tgggcggggc gcagtgcgcc
     7801 ctgaagctgc ggcagggtgg ctggcggggg cggatcgtgc tggtcgggga ggaacggcac
     7861 gcgccgtacg accggccgcc gctctccaag gacgtgctgc tcggcaagac cgacgccacc
     7921 accctggaca tcgactacgc ggggctcggc atcgagctgc tcaccggtcg ccgggccacc
     7981 ggcctgaccc cgggcgtgct gcacaccgac ggcggcgacc tcccgtacga ctcgctggtg
     8041 atcgccaccg gcgccacccc gcgcgccctg cccggagccg agcgcgccca cctgctgcac
     8101 accctggacg acgccctggc gctgcgcgcg ctgctgcgcc ccggcctgcg gctggtgctg
     8161 gtcggcgcgg gctggatcgg tgccgaggtg tccaccgccg cgcgccaggc cggctgcgag
     8221 gtcaccgtgg tcgaggccgg tccggcgccg ctgccgggcg cgctgccgac cgaggtcggc
     8281 tcggcgatgg ccgcctggta cgccgaggcc ggggtcgagc tgcgctgcgg ggtcggcgtg
     8341 gccgccgtcg aggccggggc ggtgctgctg gcggacggct cccacctgcc cgccgacgag
     8401 gtggtggtcg gcgtcggcgc ccgccccgcg accggctggc tggccggttc gggcgtcgag
     8461 ctggacgcct ccggcgcggt cgtggtggac gggcggctgc gcaccgggct gcccggggtg
     8521 ttcgcggccg gggactgcgt cagctacccc tcggcccgtt ccggcgcccg gctggccgtc
     8581 cagcactggg accacgctct gcagtcgggc gaggcggcgg ccgccgcggt gctcggggcg
     8641 gacgcgccgt acgacccggt gccgtacttc tggtccgagc agttcgggcg gatggtccag
     8701 tacctcggcc ggcacgccga gggcgacgaa ctgctgtggc gcggcagccc gcgggacgcc
     8761 gcctggtcgg tgctctggct gcgcgacggg gtgccgagcg cgctgctcgc ggtggaccgg
     8821 ccgcgcgacc tcacccaggg gcggaagctg atcgagcgcg ggacgccgct ggaccggacc
     8881 ctcgcggcgg acccgtcggt cgcgctcaag ggggccaccg cttagcgccg ggaggtgccg
     8941 aggtggcagt ctggtgccgt gagtgagatc gatgccaaga ctgacgccct ggtccccgag
     9001 tggctgtacc tgcccgacat ctccgagcgg tggggtgtgc tggtcaccga ggtccgcaac
     9061 atggtcaaga agggtgacct gatcgcggtc cgccgcggac cgaacaagtc gctgcaggtc
     9121 ccggcggcgt tcatcgacga gaccggcccg gtcaagcacc tggtcggcct gctgaccgtg
     9181 ctgcgggaca gcgggttcac cgaccaggag atcgtcgagt ggatgttcac cgaggacccg
     9241 acgctgcccg gcaccccggt gcaggcgctg tgggagaacc gcgcgaccga ggtcaagcgc
     9301 cgcgcccagg ccatggcgct gtgatgaccg acctgcggtc ccgcctggcc gacgcccggc
     9361 tctacctgtg caccgacgcc cgccgcgagc agggcgacct ggccgagttc ctggacgcgg
     9421 cgctggccgg cggggtggac atcgtccagc tccgcgacaa gggcctggag gccaagcagg
     9481 agctggcggc tttggaggtc ttcgccgacg cctgccgccg gcacggcaag ctgctgtccg
     9541 tcaacgaccg cgccgacgtc gcccacgcgg cccggccgga cgtgctgcac ctcggccagg
     9601 acgacctccc ggtgccggcc gcccgggcga tcctcggcga ggacgtgctg atcgggcgct
     9661 cctgccacgc cgagtccgag gtggacgcgg cgatcgccga gccgggcgtg gactacttct
     9721 gcaccggccc ggtctggccg accccgacca agccgggccg cccggcgccg ggcctcgggc
     9781 tggtctcgta cacggcggag caggccaccg accggccgtg gttcgcgatc ggcgggatcg
     9841 acctcggcaa cgtggacgag gtgctggccg ccggggcccg ccggatcgtc gtggtccggg
     9901 ccatcaccgc ggcggaggac ccgcgggcgg ccgccgccga gctcgcccgc cgggtgcgcg
     9961 cggtttaggg cctgcccggg ccctcccggg gccgtcgccg tcagtacttg cggacggtgg
    10021 cggcctcggc cagcgccagc agcaccgtac gggcctgctc gtcggcgagc ggcgccgcgg
    10081 ccagcgcggc cagcgactgg cccatcagct cgtcgatccg gcgttccacc agctcgggcg
    10141 cgccgctgcg ggcgaccagc tcgcgcagcc cggcgacctc ctcgacggcc aggtccggtg
    10201 cgccgagccg ggcgtccagg tgccgggcgt cggcctgcgg cagggcgcgc atcgcgtggg
    10261 cgaccagcag ggtgcgcttg ccctcgcgca ggtcgtcccc ggcgggcttg ccggtgacgg
    10321 cagggtcccc gaagacgccg agcaggtcgt cccgcagctg gaaggcctcg cccagcggca
    10381 gcccgaacgc cccgagggcc tcgaccagct ccggcccggc tccggcgagc agggcgccga
    10441 cctgcagcgg tcgctcgatc gtgtacttcg ccgacttgta gtgcaggacg gtccgcgccc
    10501 gctccagcgc gccctcgtcg gccgagtcgc cggccaccgg ctccagcacg tccaggtact
    10561 ggccgagcat gacctcggtg cgcatcaggt cgaacaccgg cttggcgccc agcacggcgg
    10621 ccgggtccag gcccgagcgc aggaacagct cgtcgcacca gatcagcagc aggtcgccga
    10681 gcagcaccgc ggccgaggcg ccgtactgct cgcggtcgcc gcgccagccg ctgtcccggt
    10741 gcagcgcctc gaagcggcgg tggatcgagg gcaggccgcg gcgggtgtcg ctgcggtcca
    10801 tcaggtcgtc gtgcaccagc gcgctggcct gcagcagctc cagcgcggcc gccgcgttgg
    10861 cgatcccctc gcccccggcc gcgccgccgg cggcccgcca gccccagtag cagaatgccg
    10921 ggcgcagccg cttgccgccg tccagcagga agtcgcgcag ggcgtcggcg gcgggcacca
    10981 gctgcggcga gatcttgccg agcagcgcgg actggtcgtc catgaacgcg gcgagggcgg
    11041 cgttgacgcg cgtgcggacg tcctccacgt caatggggtt ggccggccgg ttgctggacg
    11101 aggtcacgat gaggctccgc tggttcgctg ggggtgcagc aagcgtagcg gggccgctgg
    11161 gaacgggcgt gcgagcgggg ccgcgggggc gtgcggggcg caagcggagg cgggtccact
    11221 acttgtcccg aatcgtggaa tcgagttgtc cggccccttc ggggggcgga taacctgcca
    11281 gcatggcact cggcatcgct tccacgagat cggaccgcgc actgacggtc cgcgagctcc
    11341 tggcggccgg aaagcgctcc ttctccttcg agttcatgcc gccccgcacc gaggtcggcg
    11401 agcagaggct ctgggacgcc atccgtcgac tcgaaccgct ggacccgaac ttcgtctgca
    11461 tgacgtacgg cgccggcggc tcctcgcgcg agcgcaccgt caacatggtc ggccggatcg
    11521 ccaccgagac cacgctcacc ccggtcgccc acctgaccgc cgtggaccac tctgtcgccg
    11581 aactgcgcaa catcatcggc cagtacgccg accagggagt gcggaacgtc ctcgcggtcc
    11641 gcggcgaccc gcccggcgac ccgatgggcg aatgggtccg tcacccggac ggcgtcacct
    11701 acgcctacga gctggtggag ctgatcaagg gcatcggcga cttctgcgtc ggcgtcgcgg
    11761 cctccccgaa catgcacccg cgctcggccg actgggacga ggacatccgg cacttcatcg
    11821 cgaaggtgcg ctccggcgcg gactacgcga tcacccagat gttcttcgag gtggacgact
    11881 acctgcggtt ccgcgaccgg gtcaccgccg cgggctgcga gacgccgatc atcccggaga
    11941 tcatgccggt gaccaacgcc aagcagctgg agcgcttccc ccagctcagc ggctcggcct
    12001 tcccggccga cctggaggcc cggctgcggg ccgccgtcga cgacccggcg gcgctgcggg
    12061 ccgtcggcat ggagcacgcc accgcgatgg ccgaacgact gctcgccgag ggcgcgcccg
    12121 gcctgcactt catcacgctc aaccactcga cggcgacgct ggagatctac cagaacctgg
    12181 gcctgcacca gcgctcctag ccctctgttc acgggcccgt caccgttccg cggtggtggg
    12241 cccggtcgtg tgcggccggt gccgacggcg gcgggaacgc gatgcggtac cccggccgtt
    12301 gaaccggtac agtcgccgca cacgcgcggc gcgcgcgggc acgcgactgg aggtagcgcg
    12361 cggatgggca tcggatacct gctgctgtac gtcgcgttgg cggtggtggc gctctggctg
    12421 atcgccgagg tgctggtgca gaaccgggcg ccgctgcact ggcgggtgct cgccctggcc
    12481 ggcttcctcg gcgtggtcgt cgggatgggc ctgggctcgg tcgtggtgat cggcgccgga
    12541 gcgggcctgt tcgcggtcgg ccaggccttc gtcaccctct cggtcaagaa gggctaccag
    12601 gccggctggt ccctgcggaa ggccgacggc ggcctgcccg gcccgctcgc caaggtgccc
    12661 ctgctcggcg ccctgaccag cggcgcggcg gtcgcggccg ccgggacggc ggaggagaag
    12721 cgggtcggcg aggtcagcgc ggtcgaggag accccggtcg cgtcggcggc gccggtgccg
    12781 gccgccgagg aggagccgga ggtcgagcgg accgcgccct tcgagatgca ggaactggcc
    12841 caggacggcg tctacgcccc cgcgtactac gagcagcagc aggccccgcc gcagcaggac
    12901 ccgtacgccc ccgcctacca gtccggctac gaccagcagc agtggcagac ccagcagcag
    12961 cccgcctacg cctacgacca gcagcagtcc tacggcggct acccccagca gcaggacccg
    13021 tatggcggct accagcagca ggacccgtac gcgggctacc cgcagccggc ctgggacccg
    13081 aacgcccagc agcagcacca gcaacaccag cagcagtggc agccccagcc cgagcagcac
    13141 ggccagggca tcccgcagca gccggcgtac gaccagagcg gctacggcca ccagcagcag
    13201 aacacctggc cgtcacacgg ctgagtggaa attcccgaaa ccggccccat cgccgttgcc
    13261 gacccaatac tctgtgcgcg tacgtgcgcc gcgggctgac atcagccagg gagacggcgc
    13321 ctttcctcgg gggcaacgca tggatccgat cagcactgcg gcactggcag gcgccacgct
    13381 cgccgcgacc gcggcactcc agtccgtggg cgaggaggcc ggccggtcct cgtggacggt
    13441 ggcgtcccgt ctggtggagc gcatccggca ccggttcgcg ggcaaccacg aggccgaggg
    13501 ggcgctggcc cgggcgtgtg acagccctga cgacgaggcc gcggtggggg aactgcaccg
    13561 ggtgctgcac gagtacatgc tccgggactc cgagttcgcg caggaggttc gtcggctggt
    13621 cgacgaatcg gtgcggtcgg cgggcggagt gggcgggatc aacgcggcgg tcatcaagaa
    13681 cgtccaggtg aaccacggga aggtcgaggt cgcgggcgac ctcaacttct cctgaccgcc
    13741 gatccctcct gactcctgcc gaggcggccg agggcagcca ccaggaccgt gtgaaagatc
    13801 cagagttgag tgacgaagcg acggcgtccc acgccgagcg cggtggcgcc gatcccgccg
    13861 tgggggaccg ttccgtaccg gcgggcgacg cgaccgccga gaagcacccg gcgccctcgg
    13921 ggacggccga cgagggcgag gggccgctga acgaggcggc cgccctggtg gcgctcagca
    13981 agggagccga cgacccgcag gagtgggcgg acgccgcacg ggtggcgcag atcgcggacc
    14041 tgatcgccca ccgcctgcgg gacgacccct ccgggttgcg gatcggcacg ctggcgctgt
    14101 tccaggacac cgtgagcttc ggaggcggat tcaacgtcca cggtcacgcc gccgagcgca
    14161 ccggtgtgcc ggcctccgcc ggcggttccc tggcacggat cgagccggac gagcagaacg
    14221 gccacctcgc gtgctacgtc cggccgcacg gctacaagtc ggcgctggag ctgctgcagg
    14281 agtgccatct gatcgtgctc gcccagccac cggggaccgg ccgggcagcg gctgcggtca
    14341 acctgctggt ggaggcgctg atcgacgcgg gggcggcgga cggcggcagt tgctaccggt
    14401 cgaccgatcc gtccgccgtg ctgagcgcca cctggacgcc gccgcaccag aacgccggat
    14461 acctggtgga gctggacgac cgctcggccc gtggcagcac ggtctacgac gccgtcgact
    14521 ccggatggct gaccgccgcc gcctcggcgc tcaaggccag gaacagcttc atggtcgtga
    14581 tcaccggtcc gccccgcgga gtgctcgcct gggccgcgga ccgtaccccg tacgtgttct
    14641 cggacctcgg cgcgatcgac gccaccgagg tgctggaacg ccatgtcctg ggaccggcac
    14701 cggacgaggc ggagctcagg gacctccggg cgcggctggc gaggtcgggc gccgccgaag
    14761 cgctgcgcga gcagccggaa cccgcgatcg cggtggccct ggccaggacc gttcgagcaa
    14821 ggcgggatct ggcggagcaa gtcgcgctgc tgcgcgaccc cagcgagcag gtccgccagt
    14881 ggttcagccg ccacgaggat cttgaggcgc tgtgcttcgc ggtctccgcc gccgtgctgg
    14941 aggggtccag ctatctgacg gtgtctgacg ccgcgatcca gctgcacacg gccctggtcc
    15001 gcgacccgta cacgctgacc gggctgcgct accgggaccg gctgggacac gatcagccgt
    15061 ggatcacggt gagcggggcc gcggatgacg ggacggcgcg gccgttcgga ccgccgaagg
    15121 tcagctttcg cagcccgctg gtccggcagg ccgtcctggc ccacgcgtgg tcgtacctgg
    15181 acgggatgcg gaacgagctg ctggcgtggc tgcgcaggct gctcgtgcac agcgatgtcg
    15241 aggtccgggc ccgcgccgcc gtcgccgcag gcgtgatggc ctggagcgat cacgagcacg
    15301 ctctgcaccg gtacctctcg tcctggtcca gcagcacggt ctggccggtg cggcaggccg
    15361 ccgcgaccgc gctcggcgtc atcggcggac agcctgggct gaccgaggcg gtctggggca
    15421 ggctcgaccg gtgggccgtc gaggggacgt cggcggcggc gcggcgccag gcgaagaccg
    15481 ccgccacggc ggccggcggc ctgctcggcc gtgacgcccc ggaccgcgcg ctggccgtcc
    15541 tgcgcatcgc cctggcctgg aaggacgact ggggcaacct ggtcccggtg gcgtggagcg
    15601 tcgtccgact gaacgatcag gggcgggccg acgcggtgct ggcagcgctg ctggaatggt
    15661 cgaaggcgca ggacctctcg cccatggtcg ccaagtcgct gtcggtgttc ctgttcagcg
    15721 ccgagcggac ccatccggcc acggccggcg aggcggaccg accgtcggtg ctgtggacca
    15781 gggtcggcga actcggccgc ccgctcgagg agttgtgggc gagggcgctg gcccgcaagc
    15841 cgatccagga gcaggcgttg gccaccctcc gcacctggct gacggactac gccgagcggg
    15901 atccgagacg actgccggtg gtgcgcgagc tgctgatcgg catcgcccgc cggccgggca
    15961 agcaccgtga acgcctcgtg tactggctgg gcgtctggtc ggcggaccgc gagcgcccgt
    16021 gtcgggcggc cgcatcgctg cgcgaggccg tcgtcgcggc gacctcgcgg tgaccgggcc
    16081 gtcctttcca cgacgttgtc gaaggagcct tcgatggaca gttcgacgta cgacccggtg
    16141 ctggcgcagg agcggctcgc ctggctgagg ctgctgaacc cgctccggtc gccggaaccc
    16201 ggccgggcac tcgtcctggt gccgaacgac ggtccggcgc tcaccgtccg tccgggcgag
    16261 gagatctccg acgcatgggt cggccgttac cagaccgcgt acacggtgga caccacggag
    16321 caccggctcg tcctggagat cccgctgctc agccgggatc ccacgttcgc gttccggagc
    16381 gaggtggcgc tcgtctgcgc ggtggtcgat ccggcggagg tggtggcccg gggcatccgg
    16441 gacatgagcg acgccctgtt cgaccacatg cggcggatgc tgcgcgcggt ctccagggac
    16501 tacgacatcg cggagttcca cgaggccgag gcggcgctca accggagggt ccgcgacttc
    16561 accggagaca ccgccgtccg cctgcggaac atccacgtcg aactcctggt cgacgaggac
    16621 gaggtggcga tcagcggtcg gacgtaccgg gacgtggtcc gtgagacgcg cctcgccggc
    16681 atgcgccggc aacggcacct cgacatgctg cgggcggacg gcttcgaggg cctgatcgcg
    16741 gagatcatgg agcgggaggg gccgcgggcg gcacaggagc tcatcgccaa ggcggaggcc
    16801 gaggagcgcg aggagctgat gcgcaccttc aagctcgtcc tggagcgcgg cgacgcggac
    16861 cgtgaaccgt tcgaagtcgc caacaccgag cggatggtgc tgggccggct gctgggcggc
    16921 agtgaggctc cgttcggcgg cacccgggcc agccgggtcc gcggtggcat ggcggaccgg
    16981 gcggtcgagg accggtcgag gggatgggcc gaggaccggc cggccacggt cctgcccggg
    17041 gaggtcgttc cgccgtcgat cacaggccct ccggacgatg agccgttggc cgacaaggtg
    17101 ccgctcgaca aggcgccgac cggtgcggac ggcgggtacg gcgtgcggcg gcccggtccg
    17161 ggcccggggc cggaccgccg gacgggtgcc cgcgcgggcg aggccgagca gcccagggcg
    17221 agccgcgtgc gaggcgttca gcgggtgcgc ccggctgacg gaggcggccg atgacgacac
    17281 cgccccgggc cgtaccaccg gctccgtccg taccgcccgt cccgtccggt ccggcgatgc
    17341 ctccggaggc accgacgacg gcggtgacgc acgccgtcgg gctcgacccg caggccgggc
    17401 tcggcgcgct cagcgtgtgg accgaacgca cggcgggagc cggcgaggac gcggacccgc
    17461 tggtcctgca ccaccttccg agtcggacag gcctggtggc ggtgttcgac ggcgcgggcg
    17521 gcgccgggtc gggcccgagc tggaccaacg gccgcggtct ctcccgtagt ggggcgtgga
    17581 ccggatccag ggtggcccgg ctggccgtgg aactgtggtt ccgcgactgc gtcgagcacc
    17641 accggccccc ggaggcccgg gtactcgaag accggttgcg ggaagtcctc gacgcggccc
    17701 gccccgccgt ccgcagcaag gtggtcggca cgatgcgtcg gcagcttccg accacgatgg
    17761 cggcgatccg gtaccgcatc ggtgacacgg gcgtctcggt gcgcaccctg tgggccggcg
    17821 actcccgggc ctacgtcctg accccgagcg agggactcca ggtgctcacg cgggaccaca
    17881 ccgacgagac ggatgcgttg gcacagctca tccaggaccc gccgatgacc aatatggtct
    17941 gcgccgaccg gccgttcagg gtcgagtcgc acgccgtccc gctgaacggg ccgtgcgtgc
    18001 tgctctgcgc gaccgacggc ttcttcgggt acctgtggac gccgggggac ttcgagtccg
    18061 tgttgttgga gtccttgcag aagtcctcgg acgaggccga ctgggcggcc cggctcagcc
    18121 gcaaggtcga gcagtacacg gccgacgacg cgtcgctcgc cctggtgacg atcgggttct
    18181 ccgacttccg tgaactctgc gagcggttca gggaccgcta ccggaggagc cgcgagcgct
    18241 atcggggaat gccggacttc tccgacgcgc aggccctgcg gcactggcgc gagcaggact
    18301 ggctcaggta ccggaccgag tacgaacggc acatgcccga ggcgggggag gtcgccgaat
    18361 gaggctgggc gaggagatca acggctaccg gatcaccacc acgccgacca acaacaacgg
    18421 cgggaagtgt gtctgggcgt ttgccgagaa ggacggacgg ccgtacttca tcaagcagtt
    18481 cctggagccg aagcgcccga ggccggactc gccgggcagc gagcgcagca agcgcatccg
    18541 acaggaggtg tgccgggagt tcgaggagcg ccatcgcggc gtgatgtccc gcctgacccc
    18601 ggacatgcgg ggcggtggca acctcgtgct ggccgaggac ttcttcgccg acggcagcac
    18661 ctactacaag gtcaccgcgc ggatcgacac ctccaccctg gaacggcccc agacgctgga
    18721 accccggcag aagtcggtgc tgctgcgcac actcgccgtc agcctccaac tcctgcacgg
    18781 catcggcatc gtgcacggcg acctgaaacc cgcaaacgtg ctggtgcagg agaacaagga
    18841 caactccctc cacatcgcga agctgatcga cttcgacgac tcgtacctct cgggcagtcc
    18901 ccccggcccg cacgacatcg ccggcgactc cctctacggg gctccggaat ggcgccgcta
    18961 cgtgcaggag gacccggcgg tcgatgcccg catgctcacc accgcggcgg acatgttcgc
    19021 cctcgggctg atggcgcact actacctgac cggcgcgctg cccggctacg acgcccgcta
    19081 cgggtctccg gccgacgcgg tcaacgcagg ggaggaactc cggctcgatc cgcggctttc
    19141 cgccaccgtc aagggcctga tcacggccct gaccgggcgg gccccggaga gccgcccgag
    19201 gatcgcggcc ttcctcgcgg cgctcaagga ccccgaggcc tgcgccttgc ggcatccccg
    19261 gccggggacg gcgaaaccgt ccccggccgc ggctccggcg cccgccgcct ccgggccggt
    19321 cccgcagggg agtgccgagg cccgggtgag caggctgcgg atgaacctcg gtggcggccc
    19381 gcgcggtcgc gccgccaccg aaccggagag cacaccgccc acctcgcccg acagcccggc
    19441 ggcggagacg ccaccgaggg tgtcaagagt ccggatcaac ctcggtgacc gccgcaagta
    19501 gccaccagcc ggccgccatt gacaccgatc atccgatcat catctgacag gagaactcca
    19561 tgagcactgc tcagacgcct taccagggca acctgcagta cgccgtcgac atcgtgctgt
    19621 gcgtcgacgc cacggccagc atgggcccgg tcctcgaatc cgtgaaggcc agcgcgctct
    19681 ccttccacca gcggctggag tccgtgatgg cctcgaaggg caagtcgatc agccagctga
    19741 ggatcaagac catcgccttc cgggacttcg gcgaccgggc cgacgatgcc ctcgaggaga
    19801 cggacttcat tcaactcccg gacggagccc atgagttcga gggatttctg aaggggctgg
    19861 aggccaccgg cggcggcgac atcccggagt ccgcgctgga ggccctggcg ctcgcggtgg
    19921 gcgccccctg ggagaccggg ctggaccggc gccgacacgt catcgtgatg ttcaccgacg
    19981 ccccggccca cccgctgggc agcacccaca cgacggtgcc cgggtacccc cagtcgattc
    20041 cgcgcagcat ggacgacctg ttcgagcagt gggggtacgc ccggagtcaa gcggcggtca
    20101 tggagcagtc ggcgaagcgc ctcgtactgt tcgcgcccga tcagcagccg tggaccggga
    20161 tcgccgacga ctgggacctc acgctgcact tcccgtcgaa ggcgggcgac ggcctccagg
    20221 aattcgagat ggacgagatc atcgacacga tcgccaacag cctctgatcg cgcggtggga
    20281 tcactgccga cgatgcggct gcggtgcgtc ggagccgacc tcgtccaccg gaacgactgg
    20341 ctgaacctga tctgggacgc cggcggggaa ctgcacctgc cactcgactc gtgcacccgt
    20401 ttggacaccc ggcggatcga ggaagacggg tgcacccaga tcgtgctgtc cttcgcaccg
    20461 ctgacggaat gcggcacacg tggagcgggc tggatcaacg tccgcctcga ggtgacagcc
    20521 gagcacaacg cggacgccca cgagttcctg cagttcgtca ggcgatggac ggctgaggaa
    20581 ggagcggctg ccgtgccccg gcgaagcggc gaggaggact ggatcagctt cccgcccgcc
    20641 gacgaggcca gggaactgta cgaacaggta ctgcagcgga ccggcggcca ccggccgctg
    20701 tgacggaggg ctctggaagg agcggaccac gtggcgggtt ccacctggcg ttgcacgtcg
    20761 tgcgacacgt tcaatgccgc gagccgccgc atctgcatgg tgtgcgagaa gagacggcca
    20821 tcggcaccga aggggccgca gcctcccgcg gacggttgga agtgcacgga gtgcgaggtg
    20881 cggaacggtc cgaccgatcg gagctgcctc gcctgcgaca cgccctggcg gcccccggca
    20941 ccgcgtcgac cggagccgac gggctcggct gcttccggcg gggcgggccg tacgacggcg
    21001 aagtcccggg cgtcgggcgc cgcttcgtcg ggatccgcct cgtcccgacc cgcttcggct
    21061 ggatccgccg tgccgaagcc ggcggccgcg ccccgtccga gggcagg
//
