LOCUS       NZ_CP115450            11289 bp    DNA     linear   CON 17-DEC-2024
DEFINITION  Kitasatospora cathayae strain HUAS 3-15 chromosome, complete genome.
ACCESSION   NZ_CP115450
VERSION     NZ_CP115450.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora cathayae
  ORGANISM  Kitasatospora cathayae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8860963)
  AUTHORS   Zheng,Y., Mo,P., Li,J., Zhou,Z., Huang,K., Luo,Y., Xie,P. and
            Wang,Y.
  TITLE     Kitasatospora cathayae sp. nov., a novel endophytic actinomycete
            isolated from the leaves of Cathaya argyrophylla
  JOURNAL   Int J Syst Evol Microbiol 74 (5) (2024)
   PUBMED   38809239
REFERENCE   2  (bases 1 to 8860963)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-DEC-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 155.15x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027627435.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 15:42:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,288
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,919
            CDSs (with protein)               :: 7,919
            Genes (RNA)                       :: 113
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 256
            CDSs (without protein)            :: 256
            Pseudo Genes (ambiguous residues) :: 0 of 256
            Pseudo Genes (frameshifted)       :: 79 of 256
            Pseudo Genes (incomplete)         :: 220 of 256
            Pseudo Genes (internal stop)      :: 9 of 256
            Pseudo Genes (multiple problems)  :: 51 of 256
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:37:27
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2819690
            Orig. end                         :: 2830979
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP115450.1.
            Bacteria and source DNA available from Mo Ping.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11289
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11289
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11289
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6289](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6289
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(1764..1782)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            complement(1814..2824)
                     /locus_tag="O1G21_RS12525"
                     /old_locus_tag="O1G21_12525"
     CDS             complement(1814..2824)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105824.1"
                     /locus_tag="O1G21_RS12525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12525"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_270143359.1"
                     /transl_table=11
                     /translation="MTINRANVSAIAEDLYVWLPPKRGWGLANCGLLTSETTALWIDTP
                     YDPSLAGEFLAASRRLLPTGVDIDRVVVTHANGDHLWGAGVLPDAEVIATREALEHIHW
                     EPTPQQQHALLANSDPDSPLGGYLREHFGRFDWSTTEPVHPDTVFTGELELKVGRHPVQ
                     ITSLPAAHTGGDLMVHLPHQRAVFTGDVIFSSTPEQPGDHPSHWAGPLENIIGACEQAL
                     ATGAEIFVPGHGPVLDRDGVHGHIDYLAYVRERAHALHAAGIPALDAARRVIAEQRHPE
                     LGLPERLVLTVAAEYRHLDGTEQPGILDAMGQVALVARELAEGTAGIPHPRSARN"
     misc_feature    2815..2835
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            complement(2946..3731)
                     /locus_tag="O1G21_RS12530"
                     /old_locus_tag="O1G21_12530"
     CDS             complement(2946..3731)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS12530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_12530"
                     /product="hypothetical protein"
                     /protein_id="WP_270143361.1"
                     /transl_table=11
                     /translation="MLIASVPAVIGFLAARSLARTRLFLRYGFLRALLAPYGRVQIVIP
                     SLEVAEFAFTSDGCQLSSRGPKNVLFVPMAEARAIAELTDLLRKVNRKATIELVVAGAQ
                     DPRMPTFSIGGPGVNSYSGGVLEAVFPDFAIEYPDEVRARWGGMTFEALYNPAGELIRD
                     HGFLFVTRTPRHAPCVVLCGVFAFGSAMAVEALTAASRSSPLAALFRSGEKGFAAVEGR
                     VIGLDTVDVTVEVCRILPAPRSDVPAGFRGEVSTGRPEP"
     gene            complement(3867..4793)
                     /locus_tag="O1G21_RS12535"
                     /old_locus_tag="O1G21_12535"
     CDS             complement(3867..4793)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="O1G21_RS12535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12535"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_270143363.1"
                     /transl_table=11
                     /translation="MTTSALTIRDFRPEDAEAVAAAHRAGREHLVMTAEALLWLNAQQN
                     PDQHFRTFVAESDGRVVGAVRCAVVLGTTTAGVGYANGSVLPEFRRRGAATALLAAAER
                     HLAGHGVTELHTWLDDEPASLAFGTARGYEIGRSAQFGGRDLTLPLPPAPVRPAGVELR
                     PATEWADDPRPLFLVAADAIRDEPGEVEMDALDYEEWLRGDWARPDLDRGLTVVAVVDG
                     EPAAFTLAWTDGVDRYWSAFTACRRDFRGRGLAKLAKLESLRLAAAAGFRRAYTSNDTT
                     NAPMLAVNSWLGYERCAGERKGIKRLA"
     misc_feature    complement(4855..4868)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.28"
                     /tool="antismash"
     misc_feature    complement(4856..4865)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     misc_feature    complement(4862..4876)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.2"
                     /tool="antismash"
     gene            5001..6289
                     /locus_tag="O1G21_RS12540"
                     /old_locus_tag="O1G21_12540"
                     /pseudo=""
     CDS             5001..6289
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847911.1"
                     /locus_tag="O1G21_RS12540"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12540"
                     /product="DUF692 domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 2e-84, bitscore: 281.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPASVTRPGVGTAIELGVGLGWRSEIDTVVERQPGLDWVEVVA
                     ENICADHLPASLTVLRERGVTVVPHGVGLGLGGAGLPAPERLDKLAGAALALGSPLVTE
                     HLAFVRAGGLEAGHLLPVPRTRDSLRVIAENVRIAQDQLPVPLALENIAAQLAWPDDEF
                     TEGEFLAELVARTGVRLLIDVANLHTNRVNLGIDPAAELDRLPLEALAYVHVAGGTLVD
                     GVWHDTHAHPVTEPVLEVLAELCARVAPPGVLLERDAGFPPPSELAGELDAIRRVLEGS
                     APR"
     gene            6317..7381
                     /locus_tag="O1G21_RS12545"
                     /old_locus_tag="O1G21_12545"
     CDS             6317..7381
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="O1G21_RS12545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12545"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_270143364.1"
                     /transl_table=11
                     /translation="MWHNGYFLIPAVLLVAAALYAAQTHQRVRHVPYPQGLPGRGLPLL
                     DTAFLAGGPGRVVDTALVRMHLGEQVVISRSGLVTLTGAKPYDTVDQAVHDAVGPTGSR
                     ELGPLRRMVMRSAAVQEIGDRLADRGLMRRPERMQRARTARRLLWIAMLDLVAFAVLAL
                     LLDDHQAHHERPALLVPGFLLLLGAVTLGATSPAKGRITPAGQRQLSLMQGGTPWTPSS
                     GISPRLAGGAMLGALALGGLAVAGLENQELEEAMLAAAAQEEAIRQATASTSSSSLASS
                     PSSSSSSCGGSASWCGSSGSSGSGSSTSSCGSSSSSCGSSHHSSCGSSHSSCGSSSSSC
                     GSSCGSSCGGGCGS"
     gene            7474..8256
                     /locus_tag="O1G21_RS12550"
                     /old_locus_tag="O1G21_12550"
     CDS             7474..8256
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="O1G21_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12550"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_270143366.1"
                     /transl_table=11
                     /translation="MWLLFLIPACVAAVLSCLRLVRMTATADAIADQERSRPPEAVGIG
                     LYETAYLAGGPDRVVELALVLMAGRGRLHLAHTGWTTVVDPKGRSRLERAVVSTVGPDG
                     QCRTDELRRAMAEHPTVLEIGARLALAGLATPALIQRNTVVVVRQVRHAMLLTLVLLAA
                     SLSLSGFTGGDTIAPLAWFSLPLVLTTGTLLMARVDVYPYTRWASPVGQEVLREVRPAR
                     QRGLADDEERELLTAVAMNGPAVLPDARLRAALRPHRT"
     gene            complement(8327..9052)
                     /gene="hemQ"
                     /locus_tag="O1G21_RS12555"
                     /old_locus_tag="O1G21_12555"
     CDS             complement(8327..9052)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138586.1"
                     /locus_tag="O1G21_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12555"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_270143368.1"
                     /transl_table=11
                     /translation="MTESVEREPEQQPEKKKARDLNQVIRYTMWSVFKLKGILPEDRTA
                     LAAEVDELFAQLAAKDVTVRGTYDVSGLRADADILIWWHAEDSDDLQEAYNRFRRTGLG
                     RQLEPVWSNMALHRPAEFNKSHIPAFLADERARDYVCVYPFVRSYDWYLLPDEDRRAML
                     AEHGMQARGYPDVRANTVASFALGDYEWLLAFEADELHRIVDLMRDLRASRARMHVREE
                     VPFFTGRRKPVSELLNGLV"
     gene            complement(9049..10479)
                     /gene="hemG"
                     /locus_tag="O1G21_RS12560"
                     /old_locus_tag="O1G21_12560"
     CDS             complement(9049..10479)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138585.1"
                     /locus_tag="O1G21_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_12560"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_270143369.1"
                     /sec_met_domain="DAO (E-value: 3.3e-07, bitscore: 29.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAQVVVVGGGIAGLAAAAFLSGAAGGPARARVTVLEASGRVGG
                     KLWGGEVGGVRVDLGAESVLARRPEAVELARAVGLGEELEPPTTAKAAIWTRGALRPLP
                     GGQVMGVPGDLEALAASGVLTAEGLERARSERATEVGADVAIGRYVADRLGREVVDRLV
                     EPLLGGVYAGRADEISLRAAVPQLLPIARGGGSLVEGVHELASRPQVVGTPVFQGLRGG
                     LGTLPEAVAAACVKAGVDLRTGTPVEELRRTPEGWRLVAGGEVLTADAVVLAVPAPAAA
                     RLLRADAPAAAVELDTVEYAGMALVTLAFRRADLTEPPTGSGFLVPPVDGRRIKASTFS
                     SNKWGWLERSAPDAFLLRTSLGRHREDEVLELSDEELVARSLADLEEAIGLTARPYDTF
                     VSRFTAGLPQYPVGHLDRVARVRAAVGAVGALALCGAAYDGVGIPACIGSAAAAAAAID
                     ELLTPATGEGSTERTMGA"
ORIGIN
        1 cgcagcgctc gtgcgggtac cagtactcgt gctggtcgca gtgctcgtac gggtctcgcg
       61 ggccccggtg ccgcctccgg ctgtccgcgc cgcggcggcc cggccggagt cggtgccccg
      121 ctgcagcgcc tgccagtggg cggcggcctg ctcggggctg cggacgtacg gcgcgggctg
      181 ctcccccggg gcgctcgccg ttcccggcgc cgccgtcccg aggccggccc ccggttcctc
      241 cgcggtgagc ggacggcggc ggcgccggct gggcagcccg ctgccgtccc cgcccggcgc
      301 ggcgccctgg tccgggtcgg gcaccacgtg gatggccggc gccgggagcg ggccgggctg
      361 gtggtggcgg tcggcgagca ccggcccgtc ctgttcgtcg gcgtcgcgca tcggcgggac
      421 ggccgcgacg gcgggcgcgg gcgccgggcc ggtgccggcc cgcagcggca gcggggtgag
      481 caccgacagc ggctgctcgt cgtccaccac cgtcaccagc gcggccggga tgcgcaggat
      541 ggtccgcatg ccgccgtacg gcgagggctc gatgtggcag gcgaaaccgt actggcgggc
      601 cagcttgccg atcaccgcga agccggtctt gggcgggttg ccgagctcgg tgagcagcac
      661 gtccgacggg ccggccagca gccggcgggc ccggcgcagc tgatcctcgt ccatgccgat
      721 gccgctgtcg tcgacgatca ccagcgcgcc gcggccgccc tgctggacgg tgaccgggac
      781 gtcggtctcc gggtgggagt aggcggtggc gttggcgagc atctcggcga tggtgatggc
      841 gatcggctcg gcggcccggg cggccacggc cagtcgctgc tcgcgcaggt ggttggcgac
      901 cttgatccgg gcgtagccgg gcacccggga gagcgcgccg acgaccacct cggcgagcgg
      961 ggagtcggtc cgggccaggc ctggccaggc ctcgcacagc acggcgacgg tctggatccg
     1021 gcgcagcgcg acctcgttgc ggaagtcgac ctccagcagc cgggggtcgt cgttctcgtg
     1081 ctggagctgc tgcaccaggc tctggatctg gtacagcagg gtctggatcc gggaggtggc
     1141 gccgcgcatg gcggcccggg cggcggcgtc gacccgctcg cgttcgtcgt cgagggccgc
     1201 ggtggcggcg tccaggacgg actgcagcgc gtgcacggcc tcggggccca cggcctgcgc
     1261 gtccagtggg ccgaccggcg gggcgttggt gtgggtcagc cggacggcgg tggcggcgac
     1321 ccgctcctga gcgaggtggc cgatctcggc gaacagcgcg gcggcgtgcc gctcggcggc
     1381 ggcgagccgg tcctcggcct ccgcggcgcg ggcggccgct tcctcggcga ggaggcgcgc
     1441 ggcgttgccc tgttgctcgg cggcccggga gcgctcctcg gcgcggcggg tctgctcggc
     1501 cgagtgctgc gcggcctgct gggcctcgct caactcccgt tcggcgtggg cgagtcgtcc
     1561 ctcggccagg cgcagctgct gctcgccgcg gctgcgggcg gtctcggcgt ccgcagctgc
     1621 ggcgagggcc cgggcccggc ctcgggagag caggatcgtg gccgtgacgg ccaccaccgc
     1681 cagggcgacc agcgcgatca gcgcgatctg cgtcatcgaa gtcctcgggt gtcctcgctg
     1741 gttgggccgg gccgtcgccc gggtttccgg gccggtcgga atccggcggt cggttccggc
     1801 cggaatccgg cggtcagttc cgggcggagc gcgggtgcgg gatgccggcg gtgccctcgg
     1861 ccagttcgcg ggccaccagg gcgacctggc ccatggcgtc caggatgccg ggctgctcgg
     1921 tgccgtccag gtgccggtac tcggccgcga cggtgagcac cagccgctcg ggcaggccga
     1981 gttcggggtg gcgctgctcg gcgatcaccc gccgggcggc gtccagcgcg ggtatcccgg
     2041 cggcgtgcag ggcgtgggcg cgctcgcgga cgtacgccag gtagtcgatg tgcccgtgga
     2101 cgccgtcgcg gtcgagcacc gggccgtggc cggggacgaa gatctccgcg ccggtggcca
     2161 gtgcctgttc gcaggcgccg atgatgttct ccagcgggcc ggcccagtgc gaggggtggt
     2221 cgccgggctg ctcgggggtc gaggagaaga tcacgtcacc ggtgaacacc gcgcgctggt
     2281 gcgggaggtg gaccatgagg tcgccacccg tgtgggcggc gggcaggctg gtgatctgca
     2341 ccgggtggcg gccgaccttc agctccagtt cgccggtgaa cacggtgtcc gggtgcaccg
     2401 gctcggtggt ggaccagtcg aagcggccga agtgctcgcg gaggtagccg ccgagcgggg
     2461 agtccgggtc gctgttggcg agcagcgcgt gctgctgctg gggagtgggc tcccagtgga
     2521 tgtgttccag cgcctcgcgg gtggcgatca cctcggcgtc ggggagcacc ccggcgcccc
     2581 acaggtggtc gccgttggcg tgggtgacga ccacccggtc gatgtcgacc ccggtcggca
     2641 gcaggcgccg gctggcggcc aggaactccc cggccagtga ggggtcgtac ggggtgtcga
     2701 tccagagcgc ggtggtctcg gaggtcagca gtccgcagtt ggccaggccc cagccccgct
     2761 tcggggggag ccacacgtac aggtcctcgg caatcgcgct cacgttcgca cggttgatcg
     2821 tcatgcgcgc gattatgccc atgtcgtgtc aaggatgggg caaaacccgt acggatgact
     2881 ggagttcgtg ccccggtctc tcccgccctg tccggtttcg ttctgcgcgg tggagatcga
     2941 tcgtctcacg gctcgggacg accggtggac acctcgcccc ggaatcccgc cgggacatcg
     3001 gaccggggcg cggggaggat ccggcagacc tcgaccgtga cgtccacggt gtccagcccg
     3061 atcacccgcc cctccaccgc ggcgaatcct ttctcccccg agcggaacag cgccgccagc
     3121 ggggagctcc ggctcgccgc ggtcagcgcc tccaccgcca tcgcggagcc gaaggcgaac
     3181 accccgcaga gcaccacgca gggcgcgtgc cggggcgtgc gggtgacgaa gaggaagccg
     3241 tggtcgcgga tcagctcccc ggccgggttg tacagcgcct cgaaggtcat cccgccccag
     3301 cgggcgcgca cctcgtccgg gtactcgatg gcgaagtccg ggaacaccgc ctccagcacc
     3361 ccgccggagt aggagttgac gcccggtccg ccgatcgaga aggtcggcat ccgcggatcc
     3421 tgcgccccgg ccaccaccag ctcgatcgtc gccttccggt tgaccttccg cagcaggtcg
     3481 gtcagctccg ctatcgccct ggcctcggcc atcggcacga acagcacgtt cttcggcccc
     3541 cggctgctca gctggcagcc gtccgaggtg aaggcgaact ccgccacctc caggctcggg
     3601 atgacgatct gcacccggcc gtacggcgcc agcagcgccc gcaggaagcc gtagcgcagg
     3661 aacagtctgg tacgggcgag ggaacgggcc gcgaggaaac cgatgacggc cggaaccgat
     3721 gcgatcagca cctggagcag gatctccata tgatcccccg ggaggaagac tcgaccacga
     3781 actgtgcgcc ctggttaagt ccccgttcgt ggccgaaagt acccccatcc cggcgattcg
     3841 gagcgtgacg attcagacac ggacggtcat gccagacgct tgatcccctt gcgctccccc
     3901 gcgcagcgct cgtacccgag ccaggagttg accgcgagca tcggcgcgtt ggtggtgtcg
     3961 ttgctggtgt acgcgcgccg gaagccggcc gccgcagcga ggcgcagcga ctccagcttg
     4021 gccagcttgg ccaggccgcg gccgcggaag tcccggcggc aggcggtgaa cgcggaccag
     4081 tagcggtcca ccccgtcggt ccacgccagg gtgaacgcgg ccggctcgcc gtccaccacg
     4141 gcgaccaccg tcagcccccg gtccaggtcc ggccgggccc agtccccccg cagccactcc
     4201 tcgtagtcca gggcgtccat ctccacctcg ccgggctcgt cccggatcgc gtccgccgcc
     4261 accaggaaca gcgggcgggg atcgtccgcc cactcggtgg ccgggcgcag ctcgacaccg
     4321 gccggccgta ccggcgccgg cggcaacggc agcgtcaggt cccgcccgcc gaactgcgcg
     4381 ctgcggccga tctcgtagcc ccgggcggtg ccgaaggcca gcgaggcggg ctcgtcgtcc
     4441 agccaggtgt gcagctcggt caccccgtgg ccggccaggt gccgttcggc cgcggccagc
     4501 agcgcggtgg ccgcgccgcg ccgccggaac tccggcagca cgctgccgtt ggcgtagccg
     4561 acgccggcgg tcgtcgtccc gagcaccacc gcgcagcgca ccgcgccgac cacccggccg
     4621 tccgactcgg cgacgaaggt gcggaagtgc tggtcgggat tctgctgggc gttcagccag
     4681 agcagggcct cggcggtcat caccaggtgc tcgcgcccgg cccggtgggc ggccgccacc
     4741 gcctcggcgt cctcggggcg gaagtcacgg atcgtcagtg cgctcgtagt catgggttcg
     4801 cacgctatcc gccgccgccc gccgccgcct tcgattttcg cgaccgaacg caagctcaaa
     4861 taatgctctg agaagaccgg gtgaggcttg gcagccaccc cgcccgggga catcctcagc
     4921 agcacggccg cgcggtcctg gcgacgacgc ccgcaccgcc cgacggcctc cccacccagc
     4981 cctccgaagg gggcgcaccg atgacttccc ctgcctccgt gacccgaccc ggcgtcggga
     5041 ccgcgatcga gctcggcgtc ggcctcggct ggcgcagcga gatcgacacc gtggtcgaac
     5101 gccaacccgg tctggactgg gtcgaggtgg tcgccgagaa catctgcgcc gaccacctgc
     5161 ccgcctcgct caccgtcctg cgcgagcgcg gcgtcaccgt cgtcccgcac ggcgtcggcc
     5221 tcggcctcgg cggcgccggg ctgcccgccc cggagcggct cgacaaactc gccggggcgg
     5281 cgctcgcgct cggctcgccg ctggtcaccg agcacctggc cttcgtccgg gccggcggcc
     5341 tggaggccgg ccacctgctg cccgtccccc gcacccggga ctcgctgcgg gtgatcgccg
     5401 agaacgtccg gatcgcccag gaccagctcc cggtgccgct cgccctggag aacatcgccg
     5461 cccaactcgc ctggccggac gacgagttca ccgagggcga gttcctcgcc gaactggtcg
     5521 cccggaccgg tgtccgactg ctgatcgacg tcgccaacct gcacaccaac cgggtcaacc
     5581 tcggcatcga cccggccgcc gaactcgacc gcctgccact ggaggcgctc gcgtacgtgc
     5641 acgtcgccgg cggcaccctg gtcgacggcg tgtggcacga cacccacgcc caccccgtca
     5701 ccgaaccggt gctggaggtg ctggccgaac tgtgcgcgcg ggtcgcaccg cccggcgtcc
     5761 tgctggaacg cgacgccggc ttcccgccgc cctccgaact ggccggtgaa ctggacgcca
     5821 tccgccgggt gctggagggg agcgccccgc gatgagcgag ctggatcacg gcgagcgcac
     5881 gaccggcacc gcccgggagc gcctggcccg gcggcaggag gaactgctgg ccgccctggt
     5941 ggccggcggg cccgtcccgc ccggcttcga cccggaccag gtccgtgccc agtccaccgg
     6001 cctcgccgcc aagcggcgcg acaccaccgc gaagatcgcc cccgacctgc cccgcctgct
     6061 cggggcgcag tacgggccgc tcttcctcgg ctacgcccgc acccacccgc agaccggcgg
     6121 ctaccgcgcc gacgcccggg ccttcgccgc gtgggtgctc accgacggcg gcccgctcgc
     6181 cgccgaccac cgccgcgccc tggagcagtg gctccacccg gcgccggcgg ctgagcaggc
     6241 cccacccggc ccgctcaccc gcctgcgccg ggccctgcgc ggccgctgac ccattcacac
     6301 ctcgggggaa ccgcccatgt ggcacaacgg ctacttcctg atcccggccg tcctgctggt
     6361 cgccgccgcg ctgtacgccg cccagaccca ccagcgggtc cggcacgtcc cgtacccgca
     6421 gggcctgccc ggccgcggac tgccgctgct ggacaccgcc ttcctggccg gcggtcccgg
     6481 ccgagtcgtc gacaccgcgc tggtccggat gcacctcggc gagcaggtcg tgatcagccg
     6541 ttccggcctg gtcaccctca ccggcgccaa gccgtacgac accgtcgacc aggcggtcca
     6601 cgacgccgtc ggcccgaccg gcagccggga actcggcccg ctgcgccgca tggtgatgcg
     6661 ctcggcggcc gtccaggaga tcggcgaccg gctcgccgac cgcggcctga tgcgccgccc
     6721 cgagcggatg cagcgggccc gcaccgcccg ccgcctgctc tggatcgcga tgctcgacct
     6781 cgtggccttc gccgtgctcg ccctgctgct cgacgaccac caggcccacc acgagcgtcc
     6841 cgccctgttg gtcccgggct tcctgctgct cctcggcgcc gtcaccctgg gcgccacctc
     6901 cccggccaag ggccggatca cccccgccgg gcagcgccag ctcagcctga tgcagggcgg
     6961 caccccgtgg acgccgagct ccggcatctc gccccggctc gcgggcggcg ccatgctggg
     7021 cgcgctcgcg ctcggcggac tggccgtcgc cgggctggag aaccaggagt tggaggaggc
     7081 gatgctggcg gccgcggccc aggaggaggc gattcggcag gccaccgcga gcacctcgtc
     7141 gtcctccttg gcctcctccc cgtcctcgtc gtcctcgtcc tgcggcggct ccgccagctg
     7201 gtgcggctcc tccggctcct ccggctcagg ctcctccacg tcgagctgcg gctcgtcctc
     7261 gtcgagctgc ggctcctcgc accactccag ctgcgggtcc tcgcactcca gctgcggctc
     7321 gtcgtcgtcc agctgcgggt ccagttgcgg ttccagctgc ggcggcggct gcggctcctg
     7381 agctccggga ggccgcgcgg ccgacgtcac agttcggtat cgcggtccgg gaagccgttc
     7441 cgcgcacgac ggccccaggc atacaacaag cccatgtggt tgctgttcct gataccggcc
     7501 tgtgtcgcgg cggtgctctc ctgcctccgg ctggtgcgga tgaccgccac cgccgacgcc
     7561 atcgccgacc aggaacggtc gcgcccgccg gaggccgtcg gcatcgggct ctacgagacg
     7621 gcctacctgg ccggcggccc ggaccgggtg gtggagctcg ccctcgtcct gatggccggc
     7681 cgcggccgtc tgcacctcgc gcacaccggc tggaccaccg tggtcgaccc caagggccgc
     7741 agccgcctgg aacgtgcggt ggtctccacc gtcggccccg acggccagtg ccgtacggac
     7801 gaactgcgcc gggcgatggc cgaacacccc accgtgctgg agatcggcgc ccggctggcg
     7861 ctggccggcc tggccacccc ggccctgatc cagcgcaaca ccgtggtggt ggtccgccag
     7921 gtccggcacg cgatgctgct gaccctggtg ctgctcgccg cctcgctgtc cctcagcggc
     7981 ttcaccggcg gtgacaccat cgccccgctc gcctggttct cgctgccgct ggtgctcacc
     8041 acgggcaccc tgctgatggc ccgggtcgac gtctacccgt acacccggtg ggcctccccg
     8101 gtcggccagg aggtgctgcg cgaggtccgc ccggcccgcc agcgcggcct cgccgacgac
     8161 gaggaacgcg aactgctcac cgccgtcgcc atgaacggcc ccgccgtcct ccccgacgcc
     8221 cgcctgcgcg ccgccctccg cccgcaccgg acctgagctc cccggaacca ccggaggccg
     8281 gctccccctc agcagcaggg ggaaccggcc tccgttgcgg tgcgggtcag accaggccgt
     8341 tcagcagctc gctcaccggc ttgcggcggc cggtgaagaa cggcacctcc tcgcggacgt
     8401 gcatccgggc ccgggaggcg cgcaggtcgc gcatcaggtc gacgatccgg tgcagctcgt
     8461 ccgcctcgaa ggcgagcagc cactcgtagt cgccgagcgc gaacgaggcc accgtgttgg
     8521 cccgcacgtc cgggtagccg cgcgcctgca tgccgtgctc ggcgagcatc gcgcgccggt
     8581 cctcgtccgg cagcaggtac cagtcgtacg agcggacgaa cgggtacacg cagacgtagt
     8641 cacgcgcgcg ctcgtcggcc aggaacgccg ggatgtgcga cttgttgaac tcggccgggc
     8701 ggtgcagggc catgttcgac cagaccggct ccagctggcg gcccaggccg gtgcggcgga
     8761 agcggttgta cgcctcctgc aggtcgtccg agtcctcggc gtgccaccag atcaggatgt
     8821 cggcgtccgc gcgcagcccg gacacgtcgt aggtgccgcg caccgtcacg tccttggcgg
     8881 cgagctgggc gaacagctcg tccacctcgg cggcgagggc ggtgcggtcc tcgggcagga
     8941 tgcccttgag cttgaacacc gaccacatgg tgtagcggat gacctggttc aggtcgcgcg
     9001 ccttcttctt ctcgggctgc tgctccggct cccgctcaac gctctcagtc atgcgcccat
     9061 tgtcctctcc gtggaacctt ccccggtcgc cggggtcaac agttcgtcga tggccgccgc
     9121 ggcggcggcc gccgaaccga tgcaggccgg aatccccacc ccgtcgtacg cggcgccgca
     9181 cagcgccagg gcccccaccg cccccaccgc cgcccgcacc cgggccaccc ggtccaggtg
     9241 gcccaccggg tactgcggca ggccggccgt gaagcgcgac acgaaggtgt cgtacggccg
     9301 ggcggtcagg ccgatcgcct cctccaggtc cgccagcgag cgggccacca gctcctcgtc
     9361 cgacagctcc agcacctcgt cctcgcggtg gcggccgagc gaggtgcgca gcaggaacgc
     9421 gtccggggcg gagcgctcca gccagcccca cttgttggag gagaaggtcg aggccttgat
     9481 ccggcggccg tccaccggcg gcaccaggaa gccgctgccg gtgggcggct cggtcaggtc
     9541 ggcgcggcgg aacgccaggg tcaccagcgc catgccggcg tactcgacgg tgtccagctc
     9601 gacggccgcc gccggggcgt ccgcgcgcag cagccgggcc gcggccggcg ccgggacggc
     9661 cagcaccacg gcgtccgcgg tcagcacctc accgccggcc accaaccgcc agccctcggg
     9721 ggtgcggcgc agctcctcca ccggggtgcc ggtgcgcagg tccacgcccg ccttgacaca
     9781 ggccgcggcg accgcctccg gcagggtgcc gaggccgccg cgcagcccct ggaacaccgg
     9841 ggtgccgacc acctgcggcc gggaggccag ctcgtgcacc ccctcgacca gcgagccgcc
     9901 gccccgggcg atcggcagca gctgcggcac ggcggcgcgc agcgagatct cgtcggcgcg
     9961 cccggcgtag acgccgccca gcagcggctc gaccagccgg tccaccacct cccggcccag
    10021 ccggtcggcg acgtagcggc cgatcgcgac gtccgccccg acctcggtgg cccgctcgct
    10081 gcgggcccgc tccagcccct cggcggtgag caccccggag gcggccagcg cctccaggtc
    10141 accgggaacg cccatcacct gcccgcccgg cagtggccgc agcgcgccgc gggtccagat
    10201 cgccgccttc gcggtggtcg gcggctccag ctcctccccc agcccgaccg cccgcgccag
    10261 ctccaccgcc tccggccgcc gcgccagcac cgactcggcc ccgaggtcca cccggacccc
    10321 gccgacctcc ccgccccaca gcttcccgcc gacccgcccg gacgcctcca gcaccgtcac
    10381 ccgcgcccgg gccggccccc cggccgcccc gctcaggaag gcagccgcag cgagccccgc
    10441 gatcccacca ccgacgacga cgacctgtgc atccgacatg cttcgcagtc tcgcaggtct
    10501 ttacgccgaa ccctcaatcc gctgcacgcg agagatcgac caggaccggg aacggcaccg
    10561 gccgctccag cacgccccgc gtacccgacg aagccgagga ggaccgaccg acgcgacggt
    10621 ggcgggcccc cgcggtcccg gggcccgcca ccgcggggcg tcagcgcgcg ctggcctcgt
    10681 gcacgaaggc gaccaggcgg ctgagcgcgt ccgggtccat ggacggcatc acgccgtgcc
    10741 cgaggttgaa gatgtggccg ctggtgccga gcgcctgggc ggcgtgcagc acctcgcggg
    10801 ccttggtctc cacgaccttg gtgggggcga acagcaccgc cgggtcgagg ttgccctgca
    10861 ggcccttgcc ggggccgacg cgctcggcgg cgacgttcag cggcacccgc cagtcgacgc
    10921 cgacgatgtc cgcgccggcc tggcccatca gtccgagcag ctcgccggtg ccgacgccga
    10981 agtggatccg gggcacgccg taggaggcga ccgcgtcgaa gaccttggcg ctggccggca
    11041 tgaccgagcg gcggtagtcg tcgggcgcga gcgcgccggc ccaggagtcg aacagctgga
    11101 ccgcggaggc gcccgcctcg atctgcacct tcaggaaggc ggaggtgatg tccgcgagcc
    11161 ggtccaccag ggcggcccac agctcgggct gcccgtacat catggccttg gtgttctcgt
    11221 ggttcttgga gggcccgccc tcgaccaggt agctggccag cgtgtacggc gcaccggcga
    11281 agccgatca
//
