LOCUS       NZ_CP115450            20948 bp    DNA     linear   CON 17-DEC-2024
DEFINITION  Kitasatospora cathayae strain HUAS 3-15 chromosome, complete genome.
ACCESSION   NZ_CP115450
VERSION     NZ_CP115450.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora cathayae
  ORGANISM  Kitasatospora cathayae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8860963)
  AUTHORS   Zheng,Y., Mo,P., Li,J., Zhou,Z., Huang,K., Luo,Y., Xie,P. and
            Wang,Y.
  TITLE     Kitasatospora cathayae sp. nov., a novel endophytic actinomycete
            isolated from the leaves of Cathaya argyrophylla
  JOURNAL   Int J Syst Evol Microbiol 74 (5) (2024)
   PUBMED   38809239
REFERENCE   2  (bases 1 to 8860963)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-DEC-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 155.15x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027627435.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 15:42:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,288
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,919
            CDSs (with protein)               :: 7,919
            Genes (RNA)                       :: 113
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 256
            CDSs (without protein)            :: 256
            Pseudo Genes (ambiguous residues) :: 0 of 256
            Pseudo Genes (frameshifted)       :: 79 of 256
            Pseudo Genes (incomplete)         :: 220 of 256
            Pseudo Genes (internal stop)      :: 9 of 256
            Pseudo Genes (multiple problems)  :: 51 of 256
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:37:27
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1722374
            Orig. end                         :: 1743322
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP115450.1.
            Bacteria and source DNA available from Mo Ping.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20948
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20948
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20948
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10948](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10948
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(1599..2504)
                     /locus_tag="O1G21_RS07785"
                     /old_locus_tag="O1G21_07785"
     CDS             complement(1599..2504)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134864.1"
                     /locus_tag="O1G21_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07785"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_270141956.1"
                     /transl_table=11
                     /translation="MSTTTERPAAAATAAPGARPAKFRPRGESSPLSKALSHGVLILAS
                     LIALFPVGWILFVSLGPDKTDYLHPGEIFGKLTLSNYQHVLADTDFFTWFGNALLVSGI
                     TTVFGVLLAATTGYAVSRMKFPGHKPLMWSLLVTQMFPIAVLIVPMYTMLSELGLLDSY
                     TGLILVYSTTTVPYCAWLLKGYFDTIPVEIDEAGRVDGLSPFGTFWRLVLPLARPGLAV
                     AAFYSFLTYWAEVPFASTFMLSSDKYTLAVGLQSFVSEHDAQWNLMAATAVLIAIPSAA
                     FFYLVQRHLVTGLTAGASKS"
     gene            complement(2545..3546)
                     /locus_tag="O1G21_RS07790"
                     /old_locus_tag="O1G21_07790"
     CDS             complement(2545..3546)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018556965.1"
                     /locus_tag="O1G21_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07790"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_270141958.1"
                     /transl_table=11
                     /translation="MSVAVQGATGKGSRERDQRPGLLERLKRSYAKHWYAYAMIAPVVL
                     VLGVLVFYPLVQGIWLTLTDANSLNVARKIGVNEIPASYQYVGFHNYADILWGPGSYDR
                     FWSHFVWTIAWTVVCVCLHYTLGLGLAVLLNKKLRGRAAYRMLLILPWAVPTFVTVFSW
                     RLMLSDGGVVNTMLSALHLPEPGWLTDPWAQKAAAILVNTWAGVPFMMISLLGGLQAIP
                     AELYEAAEMDGATRWQQFRHITLPGLRSVSSTVVLLGVIWTFNQFNVIFLLFGKGAPDA
                     QLLVTWAYRLAFGQIPQDFAQSASYGVILLSILIVFTAFYRRWLARNEQANG"
     misc_feature    3540..3555
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.01"
                     /tool="antismash"
     misc_feature    complement(3542..3553)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.24"
                     /tool="antismash"
     gene            complement(3627..4907)
                     /locus_tag="O1G21_RS07795"
                     /old_locus_tag="O1G21_07795"
     CDS             complement(3627..4907)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020137305.1"
                     /locus_tag="O1G21_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07795"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_270141959.1"
                     /transl_table=11
                     /translation="MRRGIAASALVVALAVSMAACGSSGGSGSDGKADGPVTLTYWDTS
                     NATNEAPNYQELAKKFEAANPNIKVNFVNVPFDQAQNKLQTAMGAKGAPDVFRSDVGWT
                     AAFAKAGFLEPLDGTPAAADASAFQPSLIQQAKYDGKLYGVPLVTDTLGFLYNKDLFAK
                     AGITDAPKTWDELKTDAAAIKDKAGVDGFWLKAADGYYAMPFLFGEGTDTVDAANKKIT
                     ITSPEAVKGIETYKSMFTSPGTAKADVTTDAYAHMMDAFNSGKVAAIIQGPWEITNIYK
                     GSAFADKKNLGIAPVPAGSTGKAGAPTGGHNIAVYAGADKAHKAAAEKFAAFMTSAESQ
                     AFIAQKNSTLPTRSDAYTADVKADPGIAGFQAILGSAKPRPELPEYGSLFDSLGTNLGK
                     AVQGTSTQDALNTVATDYAKLLPGFAK"
     misc_feature    complement(5051..5065)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.92"
                     /tool="antismash"
     misc_feature    5052..5065
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.28"
                     /tool="antismash"
     misc_feature    complement(5189..5200)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.81"
                     /tool="antismash"
     gene            complement(5366..6442)
                     /locus_tag="O1G21_RS07800"
                     /old_locus_tag="O1G21_07800"
     CDS             complement(5366..6442)
                     /EC_number="5.1.3.-"
                     /GO_function="GO:0016857 - racemase and epimerase activity,
                     acting on carbohydrates and derivatives [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134867.1"
                     /locus_tag="O1G21_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07800"
                     /product="aldose epimerase family protein"
                     /protein_id="WP_270141961.1"
                     /transl_table=11
                     /translation="MASEATTVRREPLDPSGAGAAIQRWTLTAGPYEASVLTLGATLHT
                     LSAPDRSGRTAQLLLSTDELAQILGPARHYGTVVGRYANRIDGSSVTIDGEDHPLAPTG
                     GGMTIHGGPDGFAQRMWRAEPIEGGVLLRLHSPDGDQGFPGALDVTVSYTLSHAPGEGG
                     ELLIAYRAVTNKPTVVNLTNHAYFNLAGEGSGDVLGHLLTLDADEYTPADERQIPYGRT
                     EPVAGTPFDFTVATPIGKSVHDDHPQLAGPGGYDHNWVLRARPADGGPARAALLEDPVS
                     GRTLEVLTTEPGVQVYTANKFQGAVTGASGLPYGPFAGIALETQHFPDSPHHPAFPSTV
                     LRPGEEFRSTTVLRLGAK"
     gene            complement(6665..9664)
                     /locus_tag="O1G21_RS07805"
                     /old_locus_tag="O1G21_07805"
     CDS             complement(6665..9664)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.5"
                     /locus_tag="O1G21_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07805"
                     /product="AAA family ATPase"
                     /protein_id="WP_270141963.1"
                     /transl_table=11
                     /translation="MTDQGNELRTGTGSGRGDDGPAPRVRLRDRDAELRSVEAAVDRLC
                     REFAAGGTEIGELLAFSGRPGIGKTSLLHEVRRIASLRQGACVLFARGGERQFKEPYHV
                     LRQLLQPVLTRLEPDEFSQVMGTWEEVVGPAMGLKQPKAGARRLDPQGVRDGLDYVLTQ
                     LAPRRAPMVMIVDDLHWADAESLSWLAKFAVRSAELPVLLVFAFREDENDWPDETQELR
                     RGVLNLASRKHELSRLTLSSVTDMVRAELGDKAEDAFCYEFWNVVNGNPFEAGRLLDQV
                     RDQELEPVEENSRQLRELAVDATGMTLKSWLDRLGPATLRFAWACAMLGTDIRIDLATR
                     ISTQSTEGARESIKQLRKQRVLTQAPNGNLEFVHPLIASSIYNTMPEATRLGMHGIAAV
                     EIENAGLGLLAASRHLVETHSGEGDDRIVKKLRRAAVEHQLIGAPEAAQRCLHRALNEP
                     PADDIKAEVLYELGCSALLTDPSATVNQLRLALDPEEGPLRPELRVDATFRLSEVLAHS
                     GELGQAALVCQEEAEKTTDPVRRQRLQAASFMWHAFRKSEEDGPGRSARLAELYRNLTG
                     REAADRAVLAMRAWDLTLRGEPSTEALALADEVLDGGRLPKGLGWTDTTWGFELPSMLC
                     LTYIYNDRVAQAERLAADAIIQFEVAGWSGAHRGFAYFLMGLARFRRGLLAEAEDFLRR
                     AYRISERIGAKLPLAWDAVGVLVDTLIARGRVDEAWALANEFGFHPPYHATAMVLPDAA
                     SLYGKLLVAANRHAGAAAALTEAGAQLKVRGWHNTVWAPWAGHLAVAIAADEPERAREY
                     AQEAVRDARRFGTASAIGTALRLQAAISDGRQAVELLEQAVEHLGQSPAGYEHAVALVD
                     LGAALRRVGRLEDAQEYLYQGIELAQHCSAEKLVDRARQELANYGLRPNRLGLHDFQDT
                     LEALSGPERDVAKLAVRGVPPQRIAEQLGVHLSLVNRRLAAVYRKAGTGPDGLASALGL
                     PQRQVEGSEE"
     misc_feature    complement(9819..9831)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            10001..10948
                     /locus_tag="O1G21_RS07810"
                     /old_locus_tag="O1G21_07810"
     CDS             10001..10948
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="O1G21_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07810"
                     /product="terpene synthase family protein"
                     /protein_id="WP_270141965.1"
                     /sec_met_domain="T1TS (E-value: 5.3e-65, bitscore: 219.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDTSLQIPFPHRRSPHGRYATALHRDWLIRHPLLPDADHPGYA
                     HWEVVDLAALGYPDAGPDELALAADLMGFYFLFDDQFDGPLGRRPTEVAPICERLIAVL
                     HGARPDQRSAVETAFADLWSRSVHGMPARWQARAAYNWEYYFASHPAEAAGRISARPPD
                     RSGYLELRRGTAAMETIFDMVERLGQFEVPASVLHHPVLRQIRQLAADIPSLSNDVRSF
                     PLEAPRGDVNNLVMIVQRERRCSAEEACSAVMAEAQLMVERCAELHEQLPDVYLELGLS
                     RIERTIAGRYADGLLTWLAGYLSWEARTGRYHVV"
     gene            11235..12758
                     /locus_tag="O1G21_RS07815"
                     /old_locus_tag="O1G21_07815"
     CDS             11235..12758
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606469.1"
                     /locus_tag="O1G21_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07815"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_270141967.1"
                     /sec_met_domain="Aldedh (E-value: 8.8e-161, bitscore:
                     534.3, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYQPPGAPGSIVAYRSRYDHWIGGGWTPPVRGEYFGDPTPVTG
                     EVFTEVARGTAEDIEAALDAAHAAAPAWGRTSAAERAQVLLRIADRMEANLEQLAVAES
                     WENGKPVRETLAADLPLAVDHLRYFAGALRAQEGSLSQLDEDTVAYHFHEPLGVVGQII
                     PWNFPILMAVWKLAPALAAGNAVVLKPAEQTPASVLLLAELTADLVPPGVLNIVTGFGE
                     EAGAPLAASKRVRKLAFTGETGTGRLISRAAADNLIPVTLELGGKSPNLFFADVAAADD
                     AFYDKAVEGFAMFALNQGEVCTCPSRALIESSVYERLLGDGLARVRTMRQGNPLDTETQ
                     VGAQASAEQLKKILSYFEIGQAEGAKVLVGGERADLGGALAGGYYVTPTVFEGVNSMRV
                     FQEEIFGPVVSVTRFDGFDEAIALANDTQYGLGAGVWTRNVNTAHRAGRAIQAGRVWTN
                     CYHLYPAAAAFGGYKNSGIGRENHKALLEHYQQTKNLLVSYSPDALGFF"
     misc_feature    12903..12916
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    12907..12923
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.45"
                     /tool="antismash"
     gene            13025..13348
                     /locus_tag="O1G21_RS07820"
                     /old_locus_tag="O1G21_07820"
     CDS             13025..13348
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013004167.1"
                     /locus_tag="O1G21_RS07820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07820"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_270141969.1"
                     /transl_table=11
                     /translation="MTIAPAKLSDPTVRAFVTAINAGDREAFFRVLTPDATMSDDGSDR
                     DLNDWVDREIFESNGRMDVQTESSGGHGLVANFTNETWGEMRTAWRFTVADGKISRFET
                     GQA"
     gene            complement(13367..14587)
                     /locus_tag="O1G21_RS07825"
                     /old_locus_tag="O1G21_07825"
     CDS             complement(13367..14587)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142904.1"
                     /locus_tag="O1G21_RS07825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07825"
                     /product="serine hydrolase"
                     /protein_id="WP_270141971.1"
                     /transl_table=11
                     /translation="MVEIWGETAEGFEPVREAFARNFAEYGELGAAFALYLRGRKVVDL
                     WGGDARPEVGGRPAPAVPWTADTAQVLRSVTKGLTAATALLLAERGLLDLDAPVASYWP
                     EFAAAGKGAVPVRWLLTHQAGVPVLDVPLRLEDVLTWERAVAAVAAQAPAWEPGTAHGY
                     HPYTFGWLVGEVVRRVSGRTVGQYFAEEIARPLGLDLWIGLPAGAAPRVGKLVDLPAPE
                     AARTGPSGLRLRPKQSVRDAYQDPASLTARAFASVLPGVNMNDPAVQAAEIPGANGIGT
                     ARSVARFYAALIGVADRSDGSGTLLPPLLGPEVLARAVGPVVNGPDRVLIVNSTFGLGF
                     WRHGPTAPMASPASFGHPGRGGSLGFADPELGLGFGYVTNGMQPGVTGDVRSRNLIRAV
                     RGCLGLS"
     gene            14673..15191
                     /locus_tag="O1G21_RS07830"
                     /old_locus_tag="O1G21_07830"
     CDS             14673..15191
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576528.1"
                     /locus_tag="O1G21_RS07830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07830"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_270141973.1"
                     /transl_table=11
                     /translation="MTNPAEELLDIVDENDRVIGTALRGEVYRQGLTHRCVFIMVRDPA
                     GRIFVHRRTDTKLFAPGAYDMWVGGVVGSGESYAEAAVREAEEELGVHGIAPRPIFKFL
                     FREPDGGKLSWWCDMYEAEWDGPVSPQESEVAWHAWLTPAELSERLARDTFVPDGLEAY
                     RRYLELRAG"
     gene            15302..16177
                     /locus_tag="O1G21_RS07835"
                     /old_locus_tag="O1G21_07835"
     CDS             15302..16177
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008748350.1"
                     /locus_tag="O1G21_RS07835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07835"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_270141975.1"
                     /transl_table=11
                     /translation="MASRTPSPTADRAARTAAAPDRGAAGERPRRRLSVDERREQLIAV
                     ALELFSRRPPEEVSIDDIAAAAGASRPLVYHYFPGKQALYEASLRRAGRELSARFEEPM
                     EGPLSERLYRVMGRYLDFVQSHGPGFAALLRGGSVAASAGTSAVIDEVRRAAHDQILAH
                     LAIPAPSPGLRLTVRAWIANAEITSLEWLAERSVPLEELQLHLVQEFVAALTLTAAREP
                     MLAAELAAFFADERPDGPTGRLVQDLAGLFAVPGILDAVTALAAGAPAGGAVDEPSAQA
                     TEGSTEAPAE"
     gene            16317..18188
                     /locus_tag="O1G21_RS07840"
                     /old_locus_tag="O1G21_07840"
     CDS             16317..18188
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS07840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_07840"
                     /product="hypothetical protein"
                     /protein_id="WP_270141977.1"
                     /transl_table=11
                     /translation="MTQDVQFSAQANPFAAAEQVCATLGTLTDALFDEHTSRHPAAALS
                     ALKPAEHPAAEALFGLPLAPNGPVHEALDRLGTVITAGTARPGNGAPVADRVTAALHHR
                     YGGGAVRGAIADRGTTSAALFQLPVAGEFADAKLRPPFAPALAALAAGQQTRQPVELAT
                     GAGTEVRLVVPPGFHPLTSPGGPAGASARTVPPLPAGGEGTADADAADGPDRATVAAAA
                     ELTGHLAEVAEELFSATGPEPRRDFAVIAATLTDLIQDAGVRYAGVCALDVDGRASEAT
                     LVISLARHPLPITAFATELATVRRHAEVWTVLLPAGPAAVLVEGRTVPVPGPLAADGQR
                     RWVVTSAVQAFVPLPDGGTVLCVQLTTARPEDWELYTEAFAELLKSIQFGWDGVPLTGA
                     VAAAPATAPVAVPPPAPMTAPAPMTASAAPAASPVAEEPEEKPVHLRGTPVRIPPADFN
                     PFAPVAQEEAAADTAAAGAAEPAERKGTPVRIPPPDFDPFGIAGTAPSTDEPAAPAAAG
                     GGTAAPDPFGTTIAAEQKPDPFGTTVAAQGPAVPPPPSTPPLIPAQAAPVAAPAESAEE
                     PVKRKGTPVMIPPPDFDPFGIAGTAPTANGPEAEAEADAEPEHRPFG"
     gene            complement(18317..19021)
                     /locus_tag="O1G21_RS07845"
                     /old_locus_tag="O1G21_07845"
     CDS             complement(18317..19021)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.5"
                     /locus_tag="O1G21_RS07845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07845"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_333493551.1"
                     /transl_table=11
                     /translation="MRRGKGGERELGRERIVAVAVRVADTEGLAALSMRRVATELGVAT
                     MSLYRHVPGKDELLRLMVDQVFGEQPFPGAPAPHWRAGLEEVSRLQWRIYRSHPWLAST
                     MSFTRPVLAPDAALHTERAMAALAGLGLSGEEMAQAAVSLAAFTCGLAVHFEREAQAEQ
                     DSGVSADEWMDGLIAEDHDLLMADPERFPMFDALNRGPEIDLSLDALFEFGLARMLDGL
                     GALIEARGTGDA"
     gene            complement(<19151..19399)
                     /locus_tag="O1G21_RS41345"
                     /pseudo=""
     CDS             complement(<19151..19399)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012610.5"
                     /locus_tag="O1G21_RS41345"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGAGGALVRPVERAVVIVVESGTPSERIAAELRRRIAAGELKPGA
                     RVPSTRRIMQEWGVAMATATKVLNRLREEGLVRAVPGV"
     gene            complement(19501..20211)
                     /locus_tag="O1G21_RS07850"
                     /old_locus_tag="O1G21_07850"
     CDS             complement(19501..20211)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578711.1"
                     /locus_tag="O1G21_RS07850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_07850"
                     /product="spermidine synthase"
                     /protein_id="WP_270141979.1"
                     /transl_table=11
                     /translation="MTAALPERDGHEAVVTLDRREGPFGEVVLRQRGRHYEIIANGCFL
                     MDTADGRSERLLIQAALDELDRTGADVVAPSVLIGGLGVGFSLAYAVAEPRWGRIAIVE
                     RESAIIDWHRNGPLGGFSGGALDDERVAVIHTDLLEYLAASDGERFHALCLDIDNGPDW
                     TVTDSNSGLYGADGLTVLWHRLQPGGVLAVWSAQPSSDFEEALRAAGFTDVVSREVPVS
                     RGVPDVVHLARRSG"
ORIGIN
        1 ggctgtccag ccactcgacc tcggtgccgg cgccgaggtc gggccgggcc cgtcggacgg
       61 ccagcgcgct gcggtagagc tccagggtgg aggacgggtc gccggtctgc gcctcgacgc
      121 tcagttcggc ccactcggcc ggctgcggca gccaggacgg cccgcccgcg accggtccga
      181 agccgtacgg ggcctcgctg ccggaccacg ggatcgggac gcggcagccg tcgcggtagc
      241 cgtcctgacc ggcctgccgg aagaaggacg ggtcctggcg gacctcgtcc ggcaggtcgg
      301 tgacgtccgg caggccgagc tcctcgccct ggtagacgta cgcggagccg ggcagcgcga
      361 gcatcagcag ggtggcggcg cgggcacggc gcaggccgag cgcacggtcg ccgggggtgc
      421 ggatctgggt gccgagaccg ggctcgttgg cgaagcgggt ggcgtgccgg gtgacgtcgt
      481 ggttggacag cacccaggtg gtgggcgcgt cgaccgggcg catcgagtcg agtgagacgt
      541 cgatcacctc gcgcagcgcg gcggcgtccc aatcggtgcc caggtactgg aagttgaagg
      601 cctggtgcag ctcgtcgggg cggacgtagt tggcggtgcg ctggacggtc ggggtccagg
      661 cctcggcgac gccgatccgc tgtcccgggt actcgtcgag gatcttgcgc cagctgcggt
      721 agatctcgtg cacgccgtcc tggtcgaaga acggcatgac gtcgttgccg agcagcttga
      781 gctggtcggc gccgccgagg tcgggcaggc cgggggcctt gaccaggccg tgggcgacgt
      841 cgatgcggaa tccgtccacg cccatgtcca gccagaaccg caggatcgag cggaactcgt
      901 cggcgacggc cgggttctcc cagttgaagt cgggctgctc gggggcgaac aggtgcaggt
      961 accagtcgcc gggggtgccg tccgggttct cggtgcgggt ccaggccggg ccgccgaaga
     1021 tggactccca gtcgttgggc ggcagttcgc cgttctcgcc cttgccgggt cggaagtggt
     1081 agcgctcgcg cagcggggag ccggggccct cgcgcagggc gcgctggaac cactcgtgct
     1141 ggtccgagga gtggttgggg acgaggtcga cgatgatccg caggcccagc tggtgggcgt
     1201 cgcggatcag cgcgtcggcg tccagcaggg tgccgaacat cgggtcgacg gcgcggtagt
     1261 cggcgacgtc gtagccggcg tcggcctgcg gcgaggcgta gaacggggag agccagacgg
     1321 cgtccacgcc gaggtcgcgc aggtacggca ggcggctgcg gatgccgggc aggtcgccca
     1381 tgccgtcgcc gttggagtcg gcgaagctgc gcgggtacac ctggtagatg accgcgtccc
     1441 gccaccagcc tctggccgcg ctgccagtca caggatccag ggcggccgcc tcgtgagcgg
     1501 tgtcggcggc aggccgggag gtgtcggcca ggttctgggt catggacggt atcccttggg
     1561 gactagagga gcgaggagcg ctgaggggtg cgggagcgtt acgacttgga ggcaccggcg
     1621 gtcaggccgg tgaccaggtg gcgctgcacc aggtagaaga aggccgcgga cgggatcgcg
     1681 atgagcaccg ccgtggcggc catcaggttc cactgggcgt cgtgctcgct gacgaagctc
     1741 tgcaggccga cggccagggt gtacttgtcg gagctgagca tgaaggtgga ggcgaacggc
     1801 acctcggccc agtaggtgag gaaggagtag aaggcggcca ccgccaggcc cgggcgggcg
     1861 agcggcagca ccagccgcca gaaggtgccg aacgggctga gcccgtcgac ccggccggcc
     1921 tcgtcgatct ccaccgggat ggtgtcgaag tagcccttca gcagccaggc gcagtacggc
     1981 acggtggtgg tcgagtagac caggatcagg ccggtgtagc tgtccagcag gccgagttcg
     2041 gagagcatcg tgtacatcgg cacgatcagc accgcgatcg ggaacatctg ggtgaccagc
     2101 agcgaccaca tcagcggctt gtgcccgggg aacttcatcc gggagacggc gtagccggtg
     2161 gtggcggcga gcagcacgcc gaacacggtg gtgatgccgg agaccagcag ggcgttgccg
     2221 aaccaggtga agaagtcggt gtcggccagc acgtgctggt agttcgacag cgtgagcttg
     2281 ccgaagatct cgccggggtg gaggtagtcg gtcttgtccg gtccgagcga gacgaagagg
     2341 atccagccga ccgggaacag cgcgatcagg ctggccagga tcaggacgcc gtgggacagc
     2401 gccttggaca gcgggctgct ctcgccgcgc ggccggaact tggcgggccg ggcgcccggg
     2461 gccgcggtcg ccgcggcggc ggggcgttcg gtggtggtgc tcatcggggt tacctgcctt
     2521 cgtgggtcaa ctgggtccgg ggcctcagcc gttggcctgc tcgttgcggg cgagccagcg
     2581 ccggtagaag gcggtgaaga cgatcaggat ggacagcagg atcacgccgt aggaggcgga
     2641 ctgcgcgaag tcctggggga tctggccgaa ggcgaggcgg taggcccagg tgaccagcag
     2701 ctgggcgtcg ggggcgccct tgccgaacag caggaagatg acgttgaact ggttgaacgt
     2761 ccagatcacg ccgagcagca cgaccgtgga ggagacgctg cgcagcccgg gcagggtgat
     2821 gtggcggaac tgctgccagc gggtggcgcc gtccatctcg gccgcctcgt acagctcggc
     2881 cgggatcgcc tgcaggccgc cgagcagcga gatcatcatg aacggcacgc cggcccaggt
     2941 gttgaccagg atcgccgccg ccttctgcgc ccacgggtcg gtgagccagc cgggctcggg
     3001 caggtgcagg gcggagagca tggtgttgac gacgccgccg tcggagagca tcaggcgcca
     3061 ggagaagacg gtgacgaagg tcgggacggc ccacgggagg atgagcagca tccggtaggc
     3121 ggcgcgcccg cgcagcttct tgttgagcag gacggcgagg ccgaggccga gggtgtagtg
     3181 caggcagacg cagacgaccg tccaggcgat ggtccacacg aagtgggacc agaaccggtc
     3241 gtacgagccg gggccccaga ggatgtccgc gtagttgtgg aagccgacgt actggtagct
     3301 ggccgggatc tcgttgacgc cgatcttgcg ggcgacgttg aggctgttgg cgtcggtgag
     3361 ggtcagccag atgccctgga cgagcgggta gaacaccagg acgccgagca ccagcacgac
     3421 cggggcgatc atcgcgtagg cgtaccagtg cttggcgtag gagcgcttga ggcgttccag
     3481 caggcccgga cgctgatcgc gctcccggct gcccttgccg gtggcgccct gcacggcgac
     3541 tgacatcgtt tgcaccttct cggggggaag tctcggggga ggccgacggc ccggcccgcc
     3601 ggtgtcggcg ggccgggctg cggggactac ttggcgaagc ccggcaggag cttggcgtag
     3661 tccgtggcca cggtgttcag cgcgtcctgg gtgctggtgc cctggacggc cttgcccaga
     3721 ttggtgccga gcgagtcgaa cagcgagccg tactcgggca gttcggggcg cggcttggcg
     3781 ctgccgagga tggcctggaa gccggcgatg cccgggtcgg ccttgacgtc ggcggtgtag
     3841 gcgtcggagc gggtcggcag ggtggagttc ttctgcgcga tgaaggcctg gctctcggcc
     3901 gaggtcatga aggcggcgaa cttctcggcg gcggccttgt gggccttgtc ggcaccggcg
     3961 tagaccgcga tgttgtggcc gccggtgggc gcgccggcct tgccggtgga gccggccggg
     4021 acgggggcga tgccgaggtt cttcttgtcg gcgaaggcgg agcccttgta gatgttggtg
     4081 atctcccagg ggccctggat gatcgccgcg accttgccgc tgttgaaggc gtccatcatg
     4141 tgggcgtagg cgtcggtggt gacgtcggcc ttggccgtgc cgggcgaggt gaacatcgac
     4201 ttgtaggtct cgatgccctt gacggcctcg ggcgaggtga tggtgatctt cttgttggcg
     4261 gcgtcgacgg tgtcggtgcc ctcgccgaac aggaacggca tcgcgtagta gccgtcggcg
     4321 gccttcagcc agaagccgtc cacgccggcc ttgtccttga tcgcggcggc gtcggtcttc
     4381 agctcgtccc aggtcttggg ggcgtcggtg atgccggcct tggcgaacag gtccttgttg
     4441 tagaggaagc cgagggtgtc cgtgaccagc gggacgccgt acagcttgcc gtcgtacttg
     4501 gcctgctgga tcaggctggg ctggaaggcg gaggcgtcgg cggcggccgg ggtgccgtcc
     4561 agcggctcca ggaagccggc cttggcgaag gcggcggtcc agccgacgtc ggagcggaac
     4621 acgtccggtg cgcccttggc ccccatggcg gtctgcagct tgttctgcgc ctggtcgaac
     4681 ggcacgttga cgaagttgac cttgatgttc gggttggccg cctcgaactt cttggccagt
     4741 tcctggtagt tcggagcttc gttggtggcg ttcgacgtgt cccagtaggt gagggtgacc
     4801 gggccgtcgg ccttgccgtc cgaaccggag ccgccactgc tgccacaggc agccatcgag
     4861 accgcgaggg ccacaacgag ggcagaggcc gcgatgccac gccgcatgag aactccttgg
     4921 gagggtgggg gtgcccgaga tgttcggaga caggcgcata atggctgcct cgtgccgacc
     4981 gcatcgttgc tgccgtcggg ctcgcaagga agttaacagc ggcgcaagag tgacggaaag
     5041 tccttgcagc aagtttctgc aagaaacgcc gatcgttacg cccacgtgtc ctggacgtat
     5101 ccgagcggta gttgacagtg cggcgtgatg tccgccttcg cccctttcgc cccgctccgc
     5161 acggtcgacg cgaccaccgc gggtggctga aagcctttgc agcagactga acccatgcgc
     5221 atccgaaccg tcaccgagga cgaaccgccc ctgctgggcg aacccgccgg ggcatcggcc
     5281 ggggcatcgg ccgggcgctg atcgaacacc tcgagcgctg gccccggctc tgcacgcgcc
     5341 gggacctgcg ccggccgggc ctgccctact tggcccccag ccgcagcacc gtggtcgagc
     5401 ggaactcctc ccccggccgc agcacggtgc tcgggaaggc cgggtggtgc ggggagtccg
     5461 ggaagtgctg ggtctccagc gcgatcccgg cgaacggccc gtacggcagc ccgctcgcgc
     5521 cggtgaccgc gccctggaac ttgttcgccg tgtagacctg gacgcccggc tcggtggtca
     5581 gcacctccag ggtgcggccg ctgaccgggt cctccagcag cgccgcccgc gccggtccgc
     5641 cgtccgccgg gcgggcgcgc agcacccagt tgtggtcgta gccgcccggg ccggccagct
     5701 gcgggtggtc gtcgtgcacc gacttgccga tcggggtggc cacggtgaag tcgaagggcg
     5761 tgccggccac cggctcggtc cggccgtacg ggatctgccg ctcgtcggcc ggggtgtact
     5821 cgtcggcgtc cagggtgagc aggtggccca ggacgtcgcc gctgccctca cccgcgaggt
     5881 tgaagtaggc gtggttggtc aggttgacga cggtcggctt gttggtgacg gcgcggtagg
     5941 cgatcagcag ctcgccgccc tcgcccggag cgtgcgacag ggtgtaggag acggtgacgt
     6001 ccagcgcgcc ggggaagccc tggtcgccgt ccgggctgtg caggcgcagc agcaccccgc
     6061 cctcgatcgg ctcggcccgc cacatccgct gggcgaagcc gtccggaccg ccgtggatgg
     6121 tcatcccgcc accggtcggc gccagcgggt ggtcctcgcc gtcgatggtg acgctggagc
     6181 cgtcgatccg gttggcgtac cggcccacca ccgtgccgta gtgccgcgcc gggcccagga
     6241 tctgcgccaa ctcgtccgtg gacagcagaa gttgggccgt tcggccggac cggtccgggg
     6301 cgctgagggt gtgcagggtg gcgccgaggg tgagcacgct cgcctcgtac ggaccggccg
     6361 tcagcgtcca gcgctggatc gccgcgcccg cacccgaggg gtcgaggggt tcgcggcgca
     6421 ccgtggtggc ctcgctcgcc atggcctgct cctcactggt ggcggcagcg cgcgccgcct
     6481 ccgcccggtt cccggtccgt ccaggggcgt cgcggcggcc ccatggtgtc cgtcagccta
     6541 gcgagggcgg cggcagcggg ggcgtttcca cgcctccgcg cgccgcccga acgccaccgg
     6601 ccgcccgccc cttccacggc tgccgtcaag cagccgccac tcccccgccc cctcggcccc
     6661 gccgctactc ctccgacccc tcgacttgcc gctgcggcag cccgagcgcc gaggccagtc
     6721 cgtccggccc ggtgcccgcc ttgcggtaga ccgccgccag ccgccggttg accaggctca
     6781 ggtgcacccc cagctgctcg gcgatccgct gcggcggcac gcccctgacc gccagcttgg
     6841 cgacgtcccg ctccggcccg ctgagcgcct ccagcgtgtc ctggaagtcg tgcagcccga
     6901 gccggttggg ccgcagcccg tagttggcca gctcctgccg ggcccggtcg accagcttct
     6961 cggccgagca gtgctgggcc agctcgatgc cctggtacag gtactcctgg gcgtcctcca
     7021 gccgcccgac ccggcgcagc gcggcgccga ggtcgaccag cgccacggcg tgctcgtacc
     7081 cggccgggga ctgcccgagg tgctccacgg cctgctcgag cagctcgacc gcctgccgac
     7141 cgtccgagat cgccgcctgc agccgcagcg cggtgccgat cgccgaggcg gtgccgaagc
     7201 ggcgggcgtc ccggacggcc tcctgggcgt actcgcgggc gcgctcgggc tcgtcggccg
     7261 cgatcgcgac ggcgaggtgc ccggcccacg gcgcccagac ggtgttgtgc cagccgcgga
     7321 ccttcaactg ggccccggcc tcggtgagcg cggcggccgc cccggcgtgc cggttcgcgg
     7381 cgaccagcag cttgccgtac agcgaggcgg cgtccggcag caccatggcg gtcgcgtggt
     7441 acggcgggtg gaagccgaac tcgttggcca gcgcccaggc ctcgtcgacc cggccgcggg
     7501 cgatcagggt gtccaccagc acgccgacgg cgtcccaggc cagcggcagc ttggccccga
     7561 tccgctcgga gatgcggtag gcccggcgca ggaagtcctc ggcctcggcg agcagcccgc
     7621 ggcggaaccg ggccagcccc atcaggaagt acgcgaagcc ccggtgggcg ccgctccagc
     7681 cggccacctc gaactggatg atggcgtccg cggccagccg ctcggcctgg gcgacgcggt
     7741 cgttgtagat gtacgtgagg cagagcatcg agggcagttc gaagccccag gtggtgtcgg
     7801 tccagccgag gcccttgggc agccggccgc cgtccaggac ctcgtcggcg agcgccagcg
     7861 cctcggtgga gggctcgccg cgcagggtga ggtcccaggc gcgcatggcg agcacggccc
     7921 ggtcggcggc ctcccggccg gtcaggttcc ggtacaactc ggcgagccgg gcggagcggc
     7981 cggggccgtc ctcctcggac ttgcggaagg cgtgccacat gaacgaggcc gcctggagcc
     8041 gctgccgccg gaccgggtcg gtggtcttct cggcctcctc ctggcagacc agcgcggcct
     8101 ggcccagttc accgctgtgg gcgagcacct cggagagccg gaaggtggcg tccacccgca
     8161 gttcggggcg cagcggcccc tcctcggggt cgagggcgag cctgagctgg ttgacggtgg
     8221 cgctggggtc ggtgagcagt gcggagcagc cgagctcgta cagcacctcg gccttgatgt
     8281 cgtcggcggg cggctcgttg agcgcgcggt gcaggcagcg ctgggcggct tcgggagcgc
     8341 cgatcaactg gtgttcgacg gcggcacggc gcagcttctt gacgatccgg tcgtcgccct
     8401 cgccggagtg ggtctcgacc aggtggcggg aggcggcgag caggccgagc ccggcgttct
     8461 cgatctcgac ggcggcgatg ccgtgcatgc cgaggcgggt ggcctccggc atggtgttgt
     8521 agatggagct ggcgatcagc gggtggacga actcgaggtt cccgttgggt gcctgggtga
     8581 gcacgcgctg cttgcgcagt tgcttgatgg attcgcgggc gccctcggtg ctctgggtgg
     8641 agatccgggt ggcgaggtcg atccggatgt cggtgcccag catggcgcag gcccaggcga
     8701 agcgcagggt ggccgggccg agccggtcca gccagctctt gagggtcatc ccggtggcgt
     8761 cgaccgcgag ttcgcgcagc tgccgggagt tctcctcgac cggttcgagc tcctggtcgc
     8821 ggacctggtc gagcaggcgg ccggcctcga aggggttgcc gttgacgacg ttccagaact
     8881 cgtagcagaa ggcgtcctcg gccttgtcgc cgagttcggc gcggaccatg tcggtgacgg
     8941 agctcagggt gagcctgctg agctcgtgct tgcggctggc gaggttgagg acgccccggc
     9001 gcagctcctg ggtctcgtcg ggccagtcgt tctcgtcctc gcggaaggcg aagaccagca
     9061 gcacgggcag ctcggcggac cggacggcga acttggcgag ccaggagagg gactcggcgt
     9121 ccgcccagtg caggtcgtcg acgatcatca ccatcggcgc gcggcgcggc gcgagctggg
     9181 tgaggacgta gtcgaggccg tcgcgcacgc cctgggggtc gagccggcgg gcgccggcct
     9241 tgggctgctt gaggcccatg gccggtccga cgacctcctc ccaggtgccc atgacctggc
     9301 tgaactcgtc gggctccagt cgggtcagca cgggctggag gagctggcgc agcacgtggt
     9361 acggctcctt gaactgccgt tcgccaccgc gcgcgaacag cacgcaggcg ccctggcgca
     9421 ggctggcgat ccgtcggacc tcgtgcagca gactcgtctt gccgatgccg gggcggccgg
     9481 agaaggcgag aagttcgccg atctcggtgc cgccggcggc gaactcgcgg cagaggcggt
     9541 cgacggccgc ctcgacggac cgcagttcgg cgtcgcggtc gcgcagccgg acccggggcg
     9601 cgggtccgtc gtcgccccgg ccggaaccgg ttcccgtccg aagttcgttg ccctgatcgg
     9661 tcaccgtcgc gcctccgcct cacccgctcg cggcacggct ccgccaccgc gcggggggag
     9721 ccggtccgtc actgttcgtg gagccgagag tagcgtcgcg tacggctcat cgtgtggcat
     9781 tcgtgcaggc tggggcagac ggtgagggtt cggacagctt gccaagggca attgccctat
     9841 atccctaacg tccgatcatt gcatcagata ccctacggcc cgcgaggcgt ggatgatctt
     9901 gcctgaccca gcctcaccct tcgcgccccg ccgcgtcaac tccctcacga gaagtgctcg
     9961 aaccacaagc gcccccaccc tccgctgcac cgggagtccg atgtctgacg acacctcact
    10021 tcagatcccg ttcccacacc gccgcagtcc gcacggccgg tacgccaccg cgttgcaccg
    10081 ggactggctg atccgccacc cgctgctgcc cgacgccgac caccccggtt acgcccactg
    10141 ggaggtggtc gacctcgccg cactcggcta cccggacgcc gggccggacg aactcgccct
    10201 ggcggccgac ctgatgggct tctacttcct cttcgacgac cagttcgacg gcccgctcgg
    10261 ccgccgcccc accgaggtcg ccccgatctg cgaacgcctg atcgccgtcc tgcacggcgc
    10321 ccgccccgac cagcgctccg cggtcgagac cgccttcgcc gacctgtgga gccgcagcgt
    10381 gcacggcatg cccgcccgct ggcaggcccg cgccgcctac aactgggagt actacttcgc
    10441 cagtcacccg gccgaggcgg ccggccggat ctccgcccgg ccgccggacc ggagcggcta
    10501 cctggagctc agacggggca ccgcggcgat ggagaccatc ttcgacatgg tcgaacggct
    10561 cggccagttc gaggtccccg cctccgtgct gcaccatccg gtgctgcgtc agatccggca
    10621 gctggccgcc gacataccgt cactcagcaa cgacgtgcgc tccttcccgc tcgaagcccc
    10681 gcgcggcgac gtcaacaacc tggtgatgat cgtccaacgc gagcgccgct gctcggccga
    10741 ggaggcctgc tccgcggtga tggcggaggc ccagctgatg gtcgagcgct gcgccgaact
    10801 gcacgaacaa ctacccgacg tctacctgga gttgggcctg tcccggatcg aacgcacgat
    10861 cgccgggcgc tacgccgacg ggctgctcac ctggctggcc ggctacctca gctgggaggc
    10921 ccgcaccggc cggtaccacg tggtctgaac ggcgcggggg tgcgacgccg gagcatccgg
    10981 cgaaccgcgg gcggcccggg aaggaccggg aaggaccgga acggggaccc tccgtaccgg
    11041 accggcgtac ggaccgtagc cgcaccgcgc gtccggcggc tatcgtgctc gtcggcgggc
    11101 gcccccggca ggggcgccgc ccgagtgcgt gtccgcaccc tcccgccgga ccgcccgctg
    11161 cccgggcggc ccggcgcgcc gtccccggcc cgatcggcgc cgggggcgcc cgacgtcgcg
    11221 aggagacaca agacatgacg gtctaccagc cccccggcgc gcccggcagc atcgtcgcct
    11281 accgttcccg gtacgaccac tggatcggcg gcggatggac gcccccggtg cgcggcgagt
    11341 acttcggcga cccgaccccg gtcaccggcg aagtgttcac cgaggtcgcc cgcggcaccg
    11401 ccgaggacat cgaggccgcc ctggacgcgg cccacgccgc cgccccggcc tggggccgca
    11461 cctccgccgc cgagcgggcg caggtcctgc tgcggatcgc cgaccggatg gaggcgaacc
    11521 tggagcagct ggccgtcgcg gagagctggg agaacggcaa gccggtgcgc gagacgctgg
    11581 ccgccgacct cccgctcgcc gtcgaccacc tgcgctactt cgccggcgcg ctgcgggccc
    11641 aggagggcag cctctcccag ctggacgagg acaccgtggc gtaccacttc cacgagccgc
    11701 tgggcgtggt cggccagatc atcccgtgga acttcccgat cctgatggcg gtctggaagc
    11761 tcgccccggc gctcgcggcc ggcaacgcgg tggtgctcaa gccggccgag cagaccccgg
    11821 cctcggtgct gctgctggcc gagctgaccg ccgacctggt gccgccgggc gtgctcaaca
    11881 tcgtcaccgg cttcggcgag gaggccggcg ccccgctggc cgccagcaag cgggtccgca
    11941 aactcgcctt caccggcgag accggcaccg gccggctgat ctcccgcgcc gccgccgaca
    12001 acctgatccc ggtcaccctg gagctgggcg gcaagagccc caacctgttc ttcgcggacg
    12061 tcgccgccgc cgacgacgcc ttctacgaca aggccgtcga gggcttcgcg atgttcgccc
    12121 tcaaccaggg cgaggtctgc acctgcccca gccgcgcgct gatcgagtcc tcggtctacg
    12181 agcggctgct cggcgacggc ctggcccggg tgcgcacgat gcgccagggc aacccgctgg
    12241 acaccgagac ccaggtcggc gcgcaggcca gcgccgaaca gctgaagaag atcctctcct
    12301 acttcgagat cggccaggcc gagggcgcca aggtcctggt cggcggcgag cgcgccgacc
    12361 tcggcggcgc gctggccggc gggtactacg tgacgccgac ggtcttcgag ggcgtcaaca
    12421 gcatgcgggt cttccaggag gagatcttcg gaccggtcgt ctcggtcacc cgcttcgacg
    12481 gcttcgacga ggcgatcgcg ctcgccaacg acacccagta cgggctcggc gccggcgtgt
    12541 ggacccgcaa cgtcaacacc gcccaccgag ccgggcgcgc catccaggcg ggccgggtct
    12601 ggacgaactg ctaccacctg tacccggccg ccgcggcgtt cggcggctac aagaactccg
    12661 gcatcgggcg ggagaaccac aaggcactgt tggagcacta ccagcagacc aagaacctgc
    12721 tggtcagcta ctcccccgac gcgctcggct tcttctaggc ggttctcccg ggcggttctc
    12781 ccgggccggc cccgaccggc ccgcgacaga cgtggagcgg gagacctcgt ccggtctccc
    12841 gctccaccgc cactccccgt ggcgggcttt cggggcaaat cacctgttcc gggaatttcg
    12901 cctggttcgg gatcaaagca catgaatccg cagattttcc cgacgcgccg ccgacatgcc
    12961 cggacgggcc ccgcgaacgc cgtagacagg actccccgtt cccgatccct ccagggagtc
    13021 cggcatgacc atcgcccccg ccaagctcag cgaccccacc gtgcgcgcct tcgtcaccgc
    13081 gatcaacgcg ggcgaccgcg aggccttctt ccgcgtcctc accccggacg cgaccatgtc
    13141 cgacgacggc tccgaccgcg acctgaacga ctgggtcgac cgggagatct tcgagtcgaa
    13201 cggccggatg gacgtccaga ccgagtcctc cggcggtcac gggctggtcg ccaacttcac
    13261 caacgagacc tggggcgaga tgcgcaccgc ctggcggttc accgtcgccg acgggaagat
    13321 cagccgcttc gagaccggcc aggcctagcg agcgcacggc ccggcctcag gacagcccca
    13381 ggcacccccg caccgcgcgg atcaggttgc gcgaacggac gtccccggtg acgcccggct
    13441 gcatgccgtt ggtgacgtac ccgaagccga gcccgagctc cgggtcggcg aagcccagcg
    13501 agccgccccg gcccgggtgg ccgaagctcg ccggagaggc catcggcgcg gtcgggccgt
    13561 gccgccagaa gcccagcccg aaggtggagt tgacgatcag cacccggtcc gggccgttca
    13621 ccaccggtcc gaccgcgcgg gccagcacct ccgggccgag cagcggcggc agcagcgtgc
    13681 cggagccgtc cgaccggtcg gccacgccga tcagcgccgc gtagaaccgc gccaccgagc
    13741 gggcggtgcc gatgccgttc gcaccgggga tctcggcggc ctgcaccgcc gggtcgttca
    13801 tgttcacccc gggcagcacc gaggcgaagg cgcgggcggt cagcgaggcc gggtcctggt
    13861 aggcgtcccg gacggactgc ttgggccgca gccgcagccc gctcgggccg gtccgggccg
    13921 cctccggggc gggcaggtcg accagcttgc cgacccgggg cgcggcgccg gccggcagcc
    13981 cgatccacag gtccagcccg agcggccggg cgatctcctc ggcgaagtac tgtccgaccg
    14041 tgcggccgct cacccggcgc accacctcgc cgaccagcca gccgaaggtg tacgggtggt
    14101 agccgtgcgc cgtccccggc tcccaggcgg gcgcctgcgc ggccaccgcg gccaccgccc
    14161 gctcccaggt cagcacgtcc tccaggcgca gcggcacgtc cagcaccggc accccggcct
    14221 ggtgcgtcag cagccagcgc accggcaccg cgcccttgcc ggccgccgcg aactccggcc
    14281 agtacgaggc caccggcgcg tccaggtcga gcaggccgcg ctcggccagc agcagcgcgg
    14341 tggcggcggt caggcccttg gtgaccgagc gcagcacctg ggcggtgtcc gccgtccacg
    14401 gcaccgcggg cgcgggccgc ccgccgacct cgggccgggc gtccccgccc cacaggtcga
    14461 ccaccttgcg cccgcgcagg tacagcgcga acgccgcgcc cagttcgccg tactcggcga
    14521 agttccgcgc gaaggcctcc cgtacgggct cgaagccttc ggccgtctcg ccccagatct
    14581 ccaccaccgc gtgccgtcct caggtcgttc gtcgccgccc aattgatcga ttcctcgttc
    14641 gaagcgggcc ccgaaaccct aacctgtcgc tcatgaccaa ccccgccgaa gagctgctgg
    14701 acatcgtcga cgagaacgac cgggtgatcg gaaccgcgct gcgcggggag gtgtaccggc
    14761 aggggctgac ccaccgctgc gtgttcatca tggtccgcga tccggccggc cggatcttcg
    14821 tccaccgccg caccgacacc aagctgttcg cccccggcgc gtacgacatg tgggtcggcg
    14881 gcgtggtcgg ctccggcgag agctacgccg aggccgccgt ccgcgaggcc gaggaggaac
    14941 tcggcgtgca cggcatcgcc ccgcgcccga tcttcaagtt cctcttccgg gagcccgacg
    15001 gcggcaagct ctcctggtgg tgcgacatgt acgaggcgga gtgggacggc ccggtctcgc
    15061 cgcaggagtc cgaggtcgcc tggcacgcct ggctcacccc cgccgaactg tccgagcgcc
    15121 tcgcccgcga caccttcgtc cccgacggcc tcgaggccta ccgccgctac ctggagctcc
    15181 gggccggcta ggccgggccg gcggatctcg tctcagcggg ccggtcttcg gcgggcaggt
    15241 ccgggccgag ccaggtcagg ccgcatgggc ccggggacgg ccgccggata ggctgacgcg
    15301 catggcctcc cgtacgccgt cgccgacggc cgaccgcgca gcacggaccg ccgccgctcc
    15361 cgaccggggg gccgcgggcg agcggccgcg ccggcggctg agcgtggacg agcggcggga
    15421 gcagctgatc gccgtggcgc tggaactgtt cagccgacgc ccgccggagg aggtgtcgat
    15481 cgatgacatc gccgccgccg cgggcgcatc ccggccgctg gtgtaccact acttcccggg
    15541 caagcaggcg ctgtacgagg cctcgctgcg gcgcgccggg cgggaactct cggcgcggtt
    15601 cgaggagccc atggaggggc cgctgtcgga gcggctgtac cgggtgatgg gccgctacct
    15661 cgacttcgtg cagagccacg ggccgggctt cgccgcgctg ctgcggggcg gctcggtggc
    15721 ggccagcgcg ggtacctcgg cggtgatcga cgaggtgcgc cgggccgcgc acgaccagat
    15781 cctcgcccac ctggcgatcc ccgcgccgag ccccgggctg cgactgaccg tccgggcctg
    15841 gatcgccaac gccgagatca cctcgctgga gtggctggcc gagcgctccg ttccgctgga
    15901 ggagctgcag ctgcacctgg tgcaggagtt cgtcgccgcg ctcaccctga ccgccgcccg
    15961 ggagcccatg ctcgccgccg agctggccgc cttcttcgcc gacgagcggc ccgacgggcc
    16021 gaccgggcga ctggtccagg acctcgccgg gctgttcgcc gtccccggca tcctggacgc
    16081 ggtcaccgcg ctggccgccg gggcaccggc cggcggggcg gtggacgaac cgtccgcgca
    16141 ggccacggag ggttcgaccg aggcccccgc ggagtgatca tcgggtgatc ctgcggttcg
    16201 gcgacgacgg tgggctctga taggaatggg cggggacttg acggcacgcc gcccgggcgg
    16261 gcccggtccc acccgaacca ccgacggcag acggagcaga gcggggggct caccagttga
    16321 cccaggacgt ccagttcagt gcgcaggcca accccttcgc ggcggccgag caggtctgcg
    16381 cgaccctcgg cacactcacc gacgccctct tcgacgagca cacctcgcgc cacccggcgg
    16441 ccgcgctgag cgccctgaaa ccggctgaac acccggccgc cgaggcactg ttcggcctgc
    16501 cgctggcgcc caacgggccg gttcacgagg ccctcgaccg gctcggcacg gtgatcaccg
    16561 ccggcacggc ccggccgggc aacggcgcac cggtcgccga ccgggtgacg gccgcgctgc
    16621 accaccgcta cggcggcgga gcggtgcgcg gcgccatcgc ggaccggggc accacctcgg
    16681 ccgcgctgtt ccagctgccg gtcgccggcg agttcgccga cgccaagctg cgcccgccgt
    16741 tcgccccggc gctggccgcg ctggcggccg gtcagcagac ccggcagccg gtcgaactgg
    16801 ccaccggcgc gggcaccgag gtccggctgg tcgtcccgcc gggtttccac ccgctgacct
    16861 ccccgggcgg gcccgccggg gcctccgccc gcacggtgcc cccgctgccg gccggcggcg
    16921 aggggaccgc ggacgccgac gcggccgacg ggcccgaccg ggccacggtg gcggcggccg
    16981 ccgagctgac cgggcacctg gccgaggtcg ccgaggaact gttcagcgcc accggcccgg
    17041 agccgcgccg cgacttcgcg gtgatcgcgg cgaccctgac cgacctgatc caggacgcgg
    17101 gcgtccgcta cgcgggcgtg tgcgcgctgg acgtcgacgg gcgcgcctcc gaggccaccc
    17161 tggtcatctc gctcgcccgc cacccgctgc cgatcaccgc gttcgccacc gagctggcca
    17221 ccgtacgacg gcacgccgag gtctggacgg tcctgctgcc ggccggtccg gccgccgtcc
    17281 tggtcgaggg gcggaccgtc ccggtgcccg ggccactggc cgccgacgga cagcgtcgct
    17341 gggtggtcac atcggccgtc caggccttcg taccgctgcc ggacggcgga acggtgctgt
    17401 gcgtccagct gaccacggcc cggccggagg actgggagtt gtacacggag gcgttcgcgg
    17461 agctgctgaa gagcatccag ttcggctggg acggcgtgcc gctcaccggt gcggtcgcgg
    17521 ccgcgccggc gaccgcaccg gtggccgtgc caccgcccgc gccgatgacc gcgcccgcac
    17581 cgatgaccgc gtctgccgct ccggccgcct ccccggtggc cgaggagccg gaggagaagc
    17641 cggtgcacct gcgcggcaca ccggtgcgca ttccgcccgc ggacttcaac cccttcgctc
    17701 cggtcgcgca ggaggaggcg gcggcggaca ccgcagccgc cggcgcggcg gaaccggccg
    17761 aacgcaaggg cacgccggtc aggatcccgc cgccggactt cgaccccttc ggcatcgccg
    17821 gcacggcccc gagcacggac gaacccgctg cgccggccgc tgccggcggt ggtacggcgg
    17881 cgcccgaccc gttcgggacg acgatcgcgg ccgagcagaa gcccgacccc ttcggcacca
    17941 ccgtcgccgc ccagggcccg gccgtcccgc cgccgccctc gaccccgccg ctcatcccgg
    18001 cccaggccgc cccggtggcc gcgcccgcgg agagcgcgga ggagccggtc aagcgcaagg
    18061 gcacgccggt gatgatcccg ccgccggact tcgacccctt cggcatcgcc ggcacggccc
    18121 cgaccgcgaa cggaccggaa gcggaggccg aggccgacgc ggagccggag caccggccgt
    18181 tcggctgacg gacgaccgcc gaggattgag aacgggctga ctgccaacaa cagatgacaa
    18241 ctgacagatt tcagatttcg ttcgctgaaa tctgtcagtt gtcatctgtc agttgtcatc
    18301 tgtcagctgt catctgttac gcgtcgcccg tcccccgcgc ctcgatcagc gcccccagac
    18361 cgtccagcat ccgtgccagc ccgaactcga acaacgcgtc caggctcagg tcgatctccg
    18421 gcccccggtt cagcgcgtcg aacatcggga accgctccgg gtccgccatc agcaggtcgt
    18481 ggtcctcggc gatcagcccg tccatccact cgtccgcgga caccccgctg tcctgctcgg
    18541 cctgcgcctc ccgctcgaag tgcacggcca gcccgcaggt gaaggccgcc aggctgaccg
    18601 ctgcctgggc catctcctcc ccgctcagcc ccaggcccgc cagggcggcc atcgcccgct
    18661 cggtgtgcag cgccgcgtcg ggcgccagca ccggccgggt gaaggacatc gtggacgcca
    18721 gccacgggtg actccggtag atccgccact gcagccgcga gacctcctcc agccccgccc
    18781 gccagtgggg tgccggcgcc ccggggaacg gctgctcacc gaagacctgg tccaccatca
    18841 gccgcaacag ttcgtccttg cccggcacat ggcggtagag cgacatggtc gcgacaccca
    18901 gctcggtcgc gacccggcgc atcgacagcg ccgccagccc ctcggtgtcg gccacccgca
    18961 ccgcgaccgc gacgatccgc tcccggccga gctcccgctc cccgcccttt ccccgccgca
    19021 ccgccgcccc cgacgctcgc tccgcatcac gccccgcgtc acgacccgca gccgcggccc
    19081 cagtagccgc agtagcccca cccgcagccg gacgaggaga agctcccggc cgggccgcca
    19141 ccaccgtccc cacccccggg acggcccgca ccagcccttc ctcccgcaac cggttcagca
    19201 ccttggtcgc ggtggccatc gccacgcccc actcctgcat gatccgccgc gtggacggca
    19261 cgcgggcgcc cggcttcaac tcccctgccg cgatccggcg tcggagctcc gccgcgatcc
    19321 gctccgaagg cgtcccgctc tccaccacaa tgaccaccgc ccgctcgacc ggccgcacta
    19381 gtgcaccacc agcgcccacg ctagcagcag ccgaccgctg acctcggcgg aacccaatcg
    19441 acgcaggccc ccggccagtt gacaaccacc gtcaccaaca gcggcctgcg gcgcccccgt
    19501 tcagccggag cgccgcgcca ggtgcaccac gtccggcacg ccccggctca ccgggacctc
    19561 ccggctgacc acgtccgtga agcccgccgc ccgcagcgcc tcctcgaaat ccgacgacgg
    19621 ctgcgcgctc cacaccgcca gcaccccgcc gggctgcagc cggtgccaca gcaccgtgag
    19681 cccgtccgcc ccgtagagcc cggagttgga gtcggtgacg gtccagtccg gcccgttgtc
    19741 gatgtccagg cacaacgcgt ggaagcgctc gccgtcggac gccgccaggt actccagcag
    19801 gtcggtgtgg atcaccgcga cccgctcgtc gtccagcgca ccgccggaga agccgcccag
    19861 cggaccgttg cggtgccagt cgatgatcgc gctctcccgc tcgacgatgg cgatccgccc
    19921 ccagcgcggt tccgccaccg cgtacgcgag cgagaagccg accccgagcc cgccgatcag
    19981 caccgacggc gcgaccacgt cggcgccggt ccggtccagc tcgtccagcg ccgcctggat
    20041 cagcagccgc tcggaccgcc cgtctgcggt gtccatcagg aagcacccgt tggcgatgat
    20101 ctcgtagtgc cgtccgcgct gccgcaacac cacctcgccg aacgggccct cccgccggtc
    20161 gagcgtgacg acggcctcgt ggccgtcccg ttcgggcagt gcggcggtca tgcgtcctcc
    20221 tcgacggact cggcagcggg atcgtccggg tacgggcgat cacccgcccg acaataaccg
    20281 agtcgacccg agccatgccc atgaaataca ggccgggcac atgaacgggc cgggccccga
    20341 agggacccgg cccggcgcga accgaccccg tcaggtcgtg accagcaccc ccgcgtacga
    20401 cacaccggcg acgaccaccc acgagccgag cccgagcagc gcgatccgcc cgccggtccg
    20461 catcatggtc ggcaggtgca ccgcactccc cagcccgaac agcgcggcgg cgagcagcag
    20521 ttcctgcgcg tccccggcca gcgtgagcgc ccgctcgggc agcaccccgg tggtgcgcag
    20581 cacgatcatc gccaggaaac cgaccacgaa cagcggcacg atcggcggcc ggctgccgct
    20641 cttgaccgca ccttccgtac cgtccgcctt ggccctgcgc gcgtcgcgcg cgttgcgccg
    20701 cgccaccacg gcgacgcccg cgaccagcgg cgccagcagc accacccgca tcagcttgac
    20761 cagcacggcc tcgcgcaggg cgcccggccc gccggtctgt gcggtggcga ccacctgccc
    20821 gacgtcgtgc acgctcgccc ccacccagcg cccgaactcg agctcaccga gccccagcgg
    20881 gtgctgcagc aacggcagta cggcgatcgc cagcgtcccg cacagggtga ccagcgcgac
    20941 cgaggagg
//
