LOCUS       NZ_CP115450            22123 bp    DNA     linear   CON 17-DEC-2024
DEFINITION  Kitasatospora cathayae strain HUAS 3-15 chromosome, complete genome.
ACCESSION   NZ_CP115450
VERSION     NZ_CP115450.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora cathayae
  ORGANISM  Kitasatospora cathayae
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8860963)
  AUTHORS   Zheng,Y., Mo,P., Li,J., Zhou,Z., Huang,K., Luo,Y., Xie,P. and
            Wang,Y.
  TITLE     Kitasatospora cathayae sp. nov., a novel endophytic actinomycete
            isolated from the leaves of Cathaya argyrophylla
  JOURNAL   Int J Syst Evol Microbiol 74 (5) (2024)
   PUBMED   38809239
REFERENCE   2  (bases 1 to 8860963)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-DEC-2022) College of Life and Environment Science,
            Hunan University of Arts and Science, No. 3150 Dongting Avenue,
            Changde, Hunan 415000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 8.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 155.15x
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027627435.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 15:42:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,288
            CDSs (total)                      :: 8,175
            Genes (coding)                    :: 7,919
            CDSs (with protein)               :: 7,919
            Genes (RNA)                       :: 113
            rRNAs                             :: 11, 11, 11 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 11, 11 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 256
            CDSs (without protein)            :: 256
            Pseudo Genes (ambiguous residues) :: 0 of 256
            Pseudo Genes (frameshifted)       :: 79 of 256
            Pseudo Genes (incomplete)         :: 220 of 256
            Pseudo Genes (internal stop)      :: 9 of 256
            Pseudo Genes (multiple problems)  :: 51 of 256
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:37:27
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 94172
            Orig. end                         :: 116295
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP115450.1.
            Bacteria and source DNA available from Mo Ping.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22123
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22123
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22123
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12123](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12123)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(157..615)
                     /locus_tag="O1G21_RS00550"
                     /old_locus_tag="O1G21_00550"
     CDS             complement(157..615)
                     /NRPS_PKS="Domain: Polyketide_cyc (9-129). E-value:
                     8.9e-17. Score: 53.5. Matches aSDomain:
                     nrpspksdomains_O1G21_RS00550_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716668.1"
                     /locus_tag="O1G21_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00550"
                     /product="SRPBCC family protein"
                     /protein_id="WP_270139750.1"
                     /transl_table=11
                     /translation="MSMVKESVDVEVPLHAAYNQWTLFEEFPRFMEGVDAVTQIDDRHN
                     HWRTSIGGVSREFDTEIVDQQPDERIAWRTTDGDVEQKGVVTFQRLDDLHTRINMAIDF
                     RPEGMAEKTADVLGVVDRRVKGDLKRFKEFIEERGRAEGGWRGRISPG"
     aSDomain        complement(229..588)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_O1G21_RS00550_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="8.90E-17"
                     /label="O1G21_RS00550_Polyketide_cyc.1"
                     /locus_tag="O1G21_RS00550"
                     /protein_end="129"
                     /protein_start="9"
                     /score="53.5"
                     /tool="antismash"
                     /translation="VEVPLHAAYNQWTLFEEFPRFMEGVDAVTQIDDRHNHWRTSIGGV
                     SREFDTEIVDQQPDERIAWRTTDGDVEQKGVVTFQRLDDLHTRINMAIDFRPEGMAEKT
                     ADVLGVVDRRVKGDLK"
     gene            740..1000
                     /locus_tag="O1G21_RS00555"
                     /old_locus_tag="O1G21_00555"
     CDS             740..1000
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_00555"
                     /product="hypothetical protein"
                     /protein_id="WP_270139751.1"
                     /transl_table=11
                     /translation="MGGPSPETPEVAVYEMWAEHDPAVSPPAVVWHVVAKDDATASLCG
                     RFLEPSQRVVPAADGTGAAVPDRYCDPCLVTVREALAASGR"
     misc_feature    778..792
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.78"
                     /tool="antismash"
     gene            complement(1029..1253)
                     /locus_tag="O1G21_RS00560"
                     /old_locus_tag="O1G21_00560"
     CDS             complement(1029..1253)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998599.1"
                     /locus_tag="O1G21_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00560"
                     /product="DUF6480 family protein"
                     /protein_id="WP_270139753.1"
                     /transl_table=11
                     /translation="MTTPDPDPDRTPALDEHGALPGGDTPPAEGGISGISHPEPVEVRR
                     AWGPWPAVVIVLLALAVSAMLVGMIVVLA"
     gene            complement(1358..2263)
                     /locus_tag="O1G21_RS00565"
                     /old_locus_tag="O1G21_00565"
     CDS             complement(1358..2263)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028505.5"
                     /locus_tag="O1G21_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00565"
                     /product="DUF5133 domain-containing protein"
                     /protein_id="WP_270139755.1"
                     /transl_table=11
                     /translation="MPMVDVTALGRLVAEYDALSELRSPEAQQRLRDVCYTIAVYTGET
                     DAARAVAVARALLAPGRRGPVDGAAVATGPVADRDHGALLAELGELAERERERHRTLST
                     LPDVLQLTRVAVPGSVGAAVSTWHDDGTVETLAAGSPQLLALERAQGEAGAGPLARIRR
                     QGQGQLLVRLDPGRPGRFADRARRCGVRAVATEHLRTLPHGCTAFSVYLRTPVEPGTPA
                     SALVSVLALQASVALDRAALARTVADLLDRRHAIGPAIGVTMERFGVPPHTALILLARA
                     AQRLGTDLDTVVHRLAADGR"
     misc_feature    2385..2399
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     gene            2635..4263
                     /locus_tag="O1G21_RS00570"
                     /old_locus_tag="O1G21_00570"
     CDS             2635..4263
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013594.5"
                     /locus_tag="O1G21_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00570"
                     /product="M48 family metalloprotease"
                     /protein_id="WP_270139757.1"
                     /transl_table=11
                     /translation="MSTSGRAVTAVALLAGFYLLALGILAGQLALDVALYQELGHFGPG
                     LLKIWALSVAIGYPVVRVVFLTRRREHDGELPGVVLTRERQPAVWAMVDRIAERTGVRG
                     PAEIRLVPQVNAGVFEETRLLGLIPGKRHLVIGAPLLLGLTEGELESVLAHEFGHYSNR
                     DVKLAAVTVAGRRALLHTIGGLHQRADQHQAEEAAKLAAKAEKRLAKGRKPSREQATGG
                     VDRVLAKLFALYAKLYFRISEAVGRRQEYAADQVAARLAGRDATASALRKMPTLVAAQD
                     FYLSRYATIGWDAGLLPPPGQVYGGLLHLLSDPKRRAELAEHALDLPEEAPDPYDSHPP
                     IRLRVAAIEELPDDGRGPGAAGPALALLHDAERVLTELEVVTLVPEAAGKQRVEWAELV
                     RTAMLTHAREASAPAHRALTGLGLPATVHGLLDAVDAGRAWEFTDRLPKSEQAAAATGR
                     AAREFARPMLREELAHAVVTALAEAGLAGWELSWAGPAELRLPDGIEEGFDAALDAACA
                     DTPDTAPLRALLTGAGLPAPVAPAV"
     misc_feature    complement(4306..4319)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.16"
                     /tool="antismash"
     gene            4306..5439
                     /locus_tag="O1G21_RS00575"
                     /old_locus_tag="O1G21_00575"
     CDS             4306..5439
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS00575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_00575"
                     /product="hypothetical protein"
                     /protein_id="WP_270139759.1"
                     /transl_table=11
                     /translation="MIGIIVLAVVGLVLLFPVVMTRLAKRKLAQLERAKATIAKHEARL
                     AEEDRAKHTIVPSEHGLLPASEMVLDGEPGPEEAAALAAAKAGDWQPAAAHLGADVSAD
                     VRWKRQRELAQLAAEDDTWLRAWRAERPQDPVAALVHADALVYLAWNIRTGARASQVTR
                     EQFESFRRVLLEAEQAAVAAAALAPDDDPNPWVAQIPVAMGLNWSNDRFRELWGELTKR
                     EPHHWAAHNRALQYWCDKWHGSHELMHGFIDEAIAAAPPGSLLTPIKLEAYFEQFAQDR
                     EKPTAWKRPEVGAALDAALADLAAADPDHPRMEYTRGWLAYALTKAGRPTEALEQYRAL
                     GRVIPQPFTNFNDPRQAFIGLRVDAVQGAVAQAGKKA"
     gene            5583..6470
                     /locus_tag="O1G21_RS00580"
                     /old_locus_tag="O1G21_00580"
     CDS             5583..6470
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090732.1"
                     /locus_tag="O1G21_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00580"
                     /product="Rieske (2Fe-2S) protein"
                     /protein_id="WP_270139760.1"
                     /transl_table=11
                     /translation="MNASALHTHRWSRRLRRALEAPAHWEVLDAPAGPLADAVEALPLG
                     LSRDALRGVWLGHPLHPALVQLPIGCWTSAGLLDLAPGRSRSADALVAAGLLSAGPAAL
                     AGWVDWARLDPPRRRTGLVHALANTGGVLLYAGSLLARCRGRRGRGRLLGLAGMAAVTT
                     GGVLGGHLAYRQAAGPDRAAAVPRLAPADWAALGAVEDFPVGQPVRRRAGELAVVVVRE
                     GDRCHVLAERCAHLSGPLSEGTVVDGCLRCPWHGSEFRLRDGEVVSGPATAPQPVLETR
                     VLSGHLEVRLPGAG"
     gene            6537..7175
                     /locus_tag="O1G21_RS00585"
                     /old_locus_tag="O1G21_00585"
     CDS             6537..7175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015033707.1"
                     /locus_tag="O1G21_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00585"
                     /product="endonuclease"
                     /protein_id="WP_270139761.1"
                     /transl_table=11
                     /translation="MTVDTITSRLLAEHGRTYAEEAGITLRDKPSPLYRLLVLTVLCSI
                     RISAETATKAARELSAAGYRTPRAMADSSWQDRVDALGRAHYVRYDESTATALGEGAEL
                     LLDRWHGDLRRLRDEADGDPGSLRELLQEVPRIGPVGADIFCREVQTVWPWLRPYFDER
                     ACGAAEELGLPHTPRGLGGLVPPKDHARLAAALVRVSLSKGALEELQAA"
     gene            7401..8999
                     /locus_tag="O1G21_RS00590"
                     /old_locus_tag="O1G21_00590"
     CDS             7401..8999
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.5"
                     /locus_tag="O1G21_RS00590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00590"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_270139762.1"
                     /transl_table=11
                     /translation="MRGGRTLLRLKAGPAAAAGLLLLGFATPARAVETTVSVNNKRTGW
                     DANEPNLSPAQVSSSNFGQRWSTAVNGAVLAQPLVTGTNVIAATENNDVFGLDPATGRT
                     NWSRHLGAAWPTSTVSCNDPAAHTGITGTPVYDPSSNTVYLTSKVNDGPDVDHPHWYMH
                     ALDASTGAERTGWPVTIQGTPTNSPGHPFNAKTAAQRPGLLLMNGSVYAAFASYCDTGP
                     YVGQVVGVNASTRKVTLWSTEAGSDSMEAGIWQSGGGLVSDGSGRIFLATGNGAGTGAS
                     PSPGPGNRPPGHLGESVVRLGVNSDGSLSARDFFSPTDNRTLDKNDTDLGSGGPMALPS
                     GFGTAAHPHLLVQVGKDGRVFLLDRDNLGGMGQGPNGTDNPVSMAGPFEGVWGHPSVFG
                     GGGGYVYTVATDTGNGRSPLRALKYSVNGAGVPVLSSIGTSNEGFGYGSGSPAVTSYGP
                     NPKSALVWAVWSGSGAGGVGGELRVYDAVPVNGVMHLRRSFPIGTAAKFVVPATDDGRV
                     FVGTRDGHLVAFGSQ"
     gene            complement(9065..9961)
                     /gene="pqqB"
                     /locus_tag="O1G21_RS00595"
                     /old_locus_tag="O1G21_00595"
     CDS             complement(9065..9961)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: protein motif:HMM:TIGR02108.2"
                     /locus_tag="O1G21_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00595"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_270139764.1"
                     /transl_table=11
                     /translation="MKIRVLGTAAGGGLPQWNCGCAECAAARRSGAERSQDCLAVSGDG
                     RAWYLVNASPDLRTQLLAAPELAPAPGTRDTPLRGVLLTSGELDHTLGLLTLREADRLT
                     VHATEPVRRALHQAFPVGPLLASYTGSHWHTVTPGEPVELAGGLRAEAFALGGKRPRYA
                     ADLPGEGRPDRTDWVTGYRFTAADGAACAVYAPGLAEWTPAMDRAVAGADLVLLDGTFS
                     TADELAERTGGARRSPGMGHLAVRDSLPHLARRPGPRYLYTHLNNTNPLARRDPPRAAD
                     LAAAVAAVAEDGMLIEL"
     gene            complement(10001..11410)
                     /gene="pqqE"
                     /locus_tag="O1G21_RS00600"
                     /old_locus_tag="O1G21_00600"
     CDS             complement(10001..11410)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="O1G21_RS00600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00600"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_270139766.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.5e-17, bitscore:
                     59.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.7e-11, bitscore: 41.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.7e-21, bitscore: 76.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.5e-05, bitscore: 23.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-09, bitscore:
                     37.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.6e-07, bitscore: 30.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPAVPTAPADPVPGLRAGVRLVHDPARGRSALLHPEGVLLLN
                     DTAAAVLRHCDGRRDARSLAARLAEEYDGVDGAQVDALLAELVERRLLTLDGTGAPVRP
                     ATAAAPPGGAVRAPAPLGLIAELTYRCPLQCAYCANPVELSRYRAELDTGQWLRVLEQA
                     RGLGVLQLHLTGGEPLLRRDLTQLIAHAAELGLYTNLITSGVPLAPGRAEELAAAGLDH
                     VQLSLQDAEPRSADAIAGIAAHDRKLAAARQFTSAGLPLTVNAVLHRGNLARLGALADQ
                     AVELGADRVELAHVQYYGWAWRNRAHLAPDEEQVRQAERDVAAARERHGERVEIGYVPA
                     DLHGGTVKPCMNGWGREQLAVAPNGDVLPCLAAAQLPGLTVPNAVTDGLAASWHDSPAF
                     NRFRGTDWMPEPCRSCALRELDHGGCRCQAYQFTGDPAVTDPACRLSPHRHLVTEPVPA
                     ETPTPVPRRYR"
     aSDomain        complement(11126..11374)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_O1G21_RS00600_PqqD_RRE.1"
                     /evalue="2.30E-19"
                     /identifier="RREFam006.1"
                     /label="O1G21_RS00600"
                     /locus_tag="O1G21_RS00600"
                     /protein_end="95"
                     /protein_start="12"
                     /score="59.9"
                     /tool="antismash"
                     /translation="DPVPGLRAGVRLVHDPARGRSALLHPEGVLLLNDTAAAVLRHCDG
                     RRDARSLAARLAEEYDGVDGAQVDALLAELVERRLLTL"
     gene            complement(11407..12123)
                     /gene="pqqC"
                     /locus_tag="O1G21_RS00605"
                     /old_locus_tag="O1G21_00605"
     CDS             complement(11407..12123)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015057.5"
                     /locus_tag="O1G21_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00605"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_270139768.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.2e-72, bitscore:
                     243.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARPLSREQFAARLYDLRGRYWDTHPFHLRLHSGGCTPPELRRWV
                     ANRWYYQLCLTRKNAAIIANCPLPEVRRAWAGRLAYQDGLHHDGPAQDGPGAEGGLADW
                     LVLAEAVGLDRTEVLDERHVARGVRFAVDGYLHFCQTRPWTEGAAAALTEMFSPDHMAD
                     RVTAWREHYRWIDPAGYAYFEHRIPVARQDSARTLELVLDHCVTEAQQQAAVDALAFKC
                     EVLRAMLDAVDYGADR"
     gene            complement(12108..12275)
                     /gene="pqqA"
                     /locus_tag="O1G21_RS00610"
                     /old_locus_tag="O1G21_00610"
     CDS             complement(12108..12275)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: protein motif:HMM:TIGR02107.1"
                     /locus_tag="O1G21_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00610"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_270139769.1"
                     /transl_table=11
                     /translation="MDAARTPTPPPRATAAPTARPVGTRPAWSAPAVECHRTGAEVTAY
                     AGRAPQWRDR"
     gene            12841..14427
                     /locus_tag="O1G21_RS00615"
                     /old_locus_tag="O1G21_00615"
     CDS             12841..14427
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="O1G21_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="O1G21_00615"
                     /product="hypothetical protein"
                     /protein_id="WP_270139771.1"
                     /transl_table=11
                     /translation="MTKRILALAIGVAVLAGRAVAPVAEAAAPGPAMATVTVDGRVTNT
                     VPADAIGVNTPFWSAQFTRSDTPRRIREAGIGTLSFNAGGAGDLYHFDHGGWLSPDPYG
                     PYNGPGGYGYQNLTPRFSFDRFARTARAAGAGMLVHVNYGTGPGDTADHPSTDADPKPG
                     DPQEAADWVRYANVTRGYGVRDWVIGEEVYLNGWNKPAGPTPPGPGHDLEVREPDAHAD
                     RSPAAYARNSIEYAKAMKAVDPGIRVGIELFPYDPQRLGAPGPDARAKEWDEAVLGTPG
                     LAAAVDFVDVHWYHAHFAGVTTEAELLADTSATARAMATVRTALDRASGPDHRIDVIAG
                     ETNLDNVGNPHQRTTAGALYLLDSNLSLLENGVSQVDWWALYNGPGLFGKDGKDWGDLG
                     LLSSGECPADWSGADPCEPPAGTPFAPFHTMKLLTTALRGGGDTLAATTDNPALGVHAV
                     RRADGTLAVVLVNKDPEHAQPFRLDLPGDYRVRRTLAWHDGDDAPTVRHGSAPSTLAPY
                     SAAVILLDPRD"
     gene            14450..15580
                     /locus_tag="O1G21_RS00620"
                     /old_locus_tag="O1G21_00620"
     CDS             14450..15580
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567850.1"
                     /locus_tag="O1G21_RS00620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00620"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_270139773.1"
                     /transl_table=11
                     /translation="MKVLVAGAGIGGLCLAQGLVRAGIDVRVFEREPGPDSRYQGFRIG
                     LDEPGLAALRECLPHRLHGLLEAVTGPLAGERRVVDQQLNEVRRLGAASGGTAADRHVL
                     RQLLLAGLGDRVEFGRAVAGYQQRADGRVEARLTDGGSAVGDLLVGADGVGSAVRRQLL
                     PGAEVTALPGNALLGRTPLTEPLSGLVPGAGTLVRGADLSLLIGRMEFRRPPRLAAAEL
                     APEVELPDAHSYLRWVAMLPEPLSPEPGAWAEVRDRLLELFDGWHPDLVELVRRSDVGN
                     SSPLTIRYAEPVPHWGTGPVTLLGDAIHAMPPSAGQGANTAFRDAALLCRSLTAVHRGE
                     AELAAAVEEYELRMLERGFAAVAEGLARLAEFTPAR"
     gene            16147..17103
                     /locus_tag="O1G21_RS00625"
                     /old_locus_tag="O1G21_00625"
     CDS             16147..17103
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953976.1"
                     /locus_tag="O1G21_RS00625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00625"
                     /product="TIGR03557 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_270139775.1"
                     /transl_table=11
                     /translation="MTTAFGYFLSCEEFTPTQLVEQAELAERAGFTRLAISDHYHPWND
                     AQGSSPFVWGVIGALSRVTRLPVTTLVTCPTVRLHPAVTAQAAATADVQLPGGLRLGVG
                     TGEALNEHVLGDRWPPFDVRAEMLEEAVAVMRELFTGSLVSHRGTHYTVENARLYTPPK
                     DGRLPVYVSAFGPKAAESAAEYADGLVTMSPDTELIGRYRAAGGTGPVIGGLKVCWSPD
                     RERAVKTVHRLWPSELLPGELAQVLPTPRHFEQATELVTEEMTARSVTCGDNPQEHADR
                     LRGYVGAGFDEVYVGQIGPEQAGFFDFYREQILPRVA"
     gene            17122..18885
                     /locus_tag="O1G21_RS00630"
                     /old_locus_tag="O1G21_00630"
     CDS             17122..18885
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138616.1"
                     /locus_tag="O1G21_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00630"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_270139777.1"
                     /transl_table=11
                     /translation="MTAFPPRSLREYALLADGERGALVGPSGEIAWLCAPRWDSDPVFA
                     ALIGGTGEYAVTPVGRFVPGGYYEGRGLVRHGRWITEQGVIVCREALALPADPHRLVLL
                     RRVHADYGPARLRLRLAAGSGFDTARTRAPRRTTDGWSIRAGRLRLRWTGAQAARPHPD
                     GSLVADVALDPGERLDLVLEVSDRGLDAPPPDPDRCWRATERAWRAAVPDLRHTYDGRD
                     AAFSYAVLRGLTSPATGGMVAAATTSLPERAEEGRNYDYRYVWIRDQCLAGQAVAACGP
                     DPLLDDAVRFTTARLAEDGPRIAPAYTAAGGRVPDQHTVDLPGYPGGHDQVGNRITRQF
                     QLDAFGEALLLFAAAARHDRLGPEAHGAARTAAAAIAARWREPDAGIWELGPRQWTHSR
                     LICAAGLHAITRPRVAGAAGLTDGLAAEWSALADRLSARAARLALHPSGRWQRSPDDPA
                     PDLALLLPPVRGWPPADDPRTVATLRACREQLTDGHYAYRFRHDERPLAEAEGAFVLCG
                     FLMALAERQQGDAVEAARWFETTRGLCGSAGLFSEEYDIAQRQQRGNLPQAFVHAMLLE
                     CAARLAEPPVS"
     misc_feature    17165..17180
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.8"
                     /tool="antismash"
     gene            complement(18878..19609)
                     /locus_tag="O1G21_RS00635"
                     /old_locus_tag="O1G21_00635"
     CDS             complement(18878..19609)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117312.1"
                     /locus_tag="O1G21_RS00635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00635"
                     /product="metallophosphoesterase"
                     /protein_id="WP_270139779.1"
                     /transl_table=11
                     /translation="MIRVAAVGDIHLGPDSRGLLRPAFATLGELADVLLLAGDLTRHGT
                     VEEAAVVGEEVGGLPVPVIAVLGNHDYDADRPGEVTRILAAYGVQVLERSSTAVRVDGL
                     LVGVAGTKGFGGGFAGRSAGEFGEPEMKAFVRHSRECADGLRTALDQLAAEGCDLRIAL
                     THFAPVPDTLAGEPPEIHPFLGSYLLAEAIDGAGADLAVHGHAHLGTERGLTACGVRVR
                     NVAQPVIGRAFAVYRLHPQVS"
     gene            complement(19606..19860)
                     /locus_tag="O1G21_RS00640"
                     /old_locus_tag="O1G21_00640"
     CDS             complement(19606..19860)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016836.5"
                     /locus_tag="O1G21_RS00640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00640"
                     /product="BON domain-containing protein"
                     /protein_id="WP_270139781.1"
                     /transl_table=11
                     /translation="MTDADDTEYRLAHLRDRLADDEVGELGLRIELHGTHVTVRGTVPN
                     EQRRAAVERIVAEVLDGLTVHTDIALADGRPPSGAEDLP"
     gene            complement(19857..20516)
                     /locus_tag="O1G21_RS00645"
                     /old_locus_tag="O1G21_00645"
     CDS             complement(19857..20516)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132193.1"
                     /locus_tag="O1G21_RS00645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00645"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_270139783.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 2.5e-10, bitscore:
                     39.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRRAEHPDASRSARPEPGGWPPDDAGGSLPPDRAQAILEATKRI
                     GSLLKAKDHPFALAGGVAAYAHGADVRLQHDADFCIRREDAEAITHTLREAGLQVFLPP
                     EDWLIKARCLGQDIDLILELAKRPVTSDLLDRAEVLPVDSVQMPVLSATDLVSGLLAAF
                     SEHHCDFGAALSVVRPLREKIDWRRVRAERGQQPMAAAFLYLLERLQVIEPEEAAR"
     gene            complement(20731..21231)
                     /locus_tag="O1G21_RS00650"
                     /old_locus_tag="O1G21_00650"
     CDS             complement(20731..21231)
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953374.1"
                     /locus_tag="O1G21_RS00650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="O1G21_00650"
                     /product="hydrogenase maturation protease"
                     /protein_id="WP_270139784.1"
                     /transl_table=11
                     /translation="MGNERIVVIGVGNEYRHDDGAAVSVLAQLAAEDLAVDRLTLCDGE
                     PTRLMELWEDAGLAIVVDAVHGHPGEPGRIHSVTVDADHLLADPLVDEESPAGTHGLGL
                     GHGVALAAALGRLPRELLIVAVEGADFSIGEGLSPAVTDAVPRAVSEVRRAVEAHRAEA
                     SGP"
ORIGIN
        1 ggaccggcac accgacctgc agggcgaggc ccccggtgac acggcgggcc tgtcggccga
       61 ggaggaggcg gtgcggatcc gctccgaccg gggctgacgg cgcggcacgg gtgcggcccc
      121 gctcgcgagg agcggggccg caccggtgtg tggggatcag cccgggctga tccggccgcg
      181 ccagccgccc tccgcccggc cgcgttcctc gatgaactcc ttgaagcgct tcaggtcacc
      241 cttcacccgc cggtcgacca cgcccagcac gtcggcggtc ttctcggcca tgccctccgg
      301 ccggaagtcg atggccatgt tgattcgggt gtgcaggtcg tccagccgct ggaaggtcac
      361 cacgcccttc tgctccacgt cgccgtccgt ggtccgccag gcgatccgct cgtcgggctg
      421 ctggtcgacg atctcggtgt cgaactcccg actgacccca ccgatgctgg tgcgccagtg
      481 gttgtggcgg tcgtcgatct gggtcaccgc gtcgacgccc tccatgaagc gggggaactc
      541 ctcgaacagc gtccactggt tgtaggcggc gtgcagcggg acctcgacgt caacggactc
      601 cttcaccatg ctcatctggg gcctcctcgg gtctcccggc cgggtccgtc ccggccgacc
      661 gcgcgtgtgc ccgtctccca acggcgtaac catcccaccg gactcggccc ggtggccgag
      721 cggggtgtcc cggggttgca tggggggacc gagccccgag accccggagg tcgccgtgta
      781 cgagatgtgg gccgagcacg acccggcggt gtcgccgccc gccgtggtgt ggcacgtggt
      841 ggcgaaggac gacgcgacgg cgtcgctgtg cgggcggttc ctcgaaccgt cccaacgggt
      901 ggtaccggcc gccgacggca ccggcgcggc ggtaccggac cggtactgcg acccctgcct
      961 ggtgaccgtc cgcgaggccc tcgcggccag cggtcgctga ccccccggcc gacgggccgc
     1021 agggcgcgtc aggccagtac gacgatcatg ccgaccagca tggcggagac cgccagcgcc
     1081 agtagcacga tcacgacggc gggccagggc ccccaggccc gccgtacttc cacgggctcc
     1141 gggtgcgaga tgccggagat tccaccctcg gccggtgggg tgtccccgcc gggcagtgcg
     1201 ccgtgttcgt ccagcgccgg ggtgcggtcg ggatcgggat cgggtgtggt catgatgtcg
     1261 tcccaagtcg aagtggctcc gacacccggc ggctgccccg ggccgccgct cggaaacacc
     1321 accgttcccg cgaacccggt ccccggtccg tcgaccgcta ccggccgtcc gccgcgagcc
     1381 ggtggaccac ggtgtcgagg tccgtgccca gccgctgggc tgcccgggcg agcaggatca
     1441 gcgcggtgtg cgggggcacc ccgaaccgct ccatggtgac gccgatggcc ggaccgatgg
     1501 cgtgccggcg gtcgagcagg tcggcgaccg tccgggccag ggccgcgcgg tccagcgcga
     1561 ccgaggcctg cagggcgagg acggagacca gcgcgctcgc cggggtgccg ggttccaccg
     1621 gcgtccgcag gtagacgctg aaggcggtgc acccgtgcgg cagggtacgc aggtgctcgg
     1681 tggccacggc gcgcaccccg cagcgacggg cccggtccgc gaaccgcccg gggcggcccg
     1741 ggtcgagccg gaccagcagc tgcccctggc cctggcggcg gatccgggcg agcggcccgg
     1801 cgcccgcctc gccctgggcc cgttccagcg ccagcaactg cggggagccg gcggccagcg
     1861 tctcgacggt gccgtcgtcg tgccaggtgc tcaccgcggc gccgacgctg ccgggcacgg
     1921 cgaccctggt cagctggagg acgtccggca gggtcgacaa cgtccggtgc cgttcccgct
     1981 cccgctcggc gagttcgccg agttcggcca gcagcgcccc gtggtcccgg tcggcgaccg
     2041 gcccggtcgc cacggcggcg ccgtcgacgg gcccccggcg gcccggggcc agcagggcgc
     2101 gggccaccgc gacggcgcgg gcggcgtccg tctcgccggt gtagacggcg atggtgtagc
     2161 agacgtcgcg caggcgctgc tgggcttcgg gcgagcgcag ctccgacagg gcgtcgtact
     2221 ccgcgaccag tcggccgagc gccgtgacat ccaccatggg catgagaacc tccggacgtg
     2281 tccggacagt atgcaaccga tcacgccggg gaaccgcacc ccggccgggg gccgttcggg
     2341 tcagccggcc agggcttgtc cggcgattcg cacccggcgg gaatcgttac tctcggccac
     2401 tgcagccgaa tcggggtaag gaatccccgc aagcccgcac gaatcggaat tcgcgacgaa
     2461 cccgcaggtc ggagccgtgt tccgggggca agaactccgg tgcgcgggac gtcccgtggc
     2521 cgctacgatc ctcactcgtc gtacacccgt tcaccatgca cagaccgcgc gccgccctgt
     2581 cgtcgcgccc agggggagga ccatcgcatg ggcgcgcccc agcgttccac cgccatgagc
     2641 acatccggcc gcgccgtcac ggccgtggcc ctgctcgccg gcttctacct gctcgccctc
     2701 ggcatcctcg cgggccagct ggccctcgac gtcgccctgt accaggagct gggccacttc
     2761 ggcccggggc tgctcaagat ctgggccctg agcgtcgcga tcggctaccc ggtggtccgg
     2821 gtggtgttcc tgacccgccg ccgcgagcac gacggcgagc tgcccggcgt ggtgctcacc
     2881 cgcgagcggc agcccgccgt gtgggccatg gtcgaccgga tcgccgagcg gaccggcgtc
     2941 cgcggaccgg ccgagatccg gctggtgccc caggtcaacg caggcgtgtt cgaggagacc
     3001 aggctgctcg gcctgattcc cggcaagcgt cacctggtca tcggcgcccc gctgctgctc
     3061 ggcctcaccg agggcgagct ggagtccgta ctggcccacg agttcggcca ctacagcaac
     3121 cgggacgtca agctggccgc cgtcaccgtc gccggccgcc gcgccctcct gcacaccatc
     3181 ggcgggctgc accagcgcgc cgaccagcac caggccgagg aggccgccaa gctcgccgcc
     3241 aaggccgaga agcggctcgc caagggccgc aagccgtccc gggagcaggc gaccggcggc
     3301 gtcgaccggg tcctcgccaa gctcttcgcg ctctacgcca agctgtactt ccggatctcc
     3361 gaggcggtcg gccgccgcca ggagtacgcg gccgaccagg tcgccgcccg gctcgccggc
     3421 cgcgacgcca ccgcctcggc gctgcgcaag atgccgacgc tggtcgccgc ccaggacttc
     3481 tacctcagcc gctacgccac catcggctgg gacgccggcc tgctcccgcc gcccggccag
     3541 gtctacggcg gcctgctcca cctgctgagc gaccccaagc gccgggcgga gctcgccgag
     3601 cacgcgctgg acctgcccga ggaggctccc gacccctacg actcgcaccc tccgatccgg
     3661 ctgcgggtcg ccgcgatcga ggagctgccc gacgacgggc gcggccccgg cgccgccggc
     3721 cccgccctcg cgctgctgca cgacgcggag cgggtgctca ccgagctgga ggtcgtcacg
     3781 ctggtccccg aggcggccgg caagcagcgg gtcgaatggg ccgaactggt ccgcacggcg
     3841 atgctgaccc acgcccgcga ggcctccgcc ccggcccacc gggccctgac cgggctgggc
     3901 ctgcccgcca ccgtccacgg actgctcgac gccgtcgacg ccggccgggc ctgggagttc
     3961 accgaccggc tgcccaagag cgagcaggcc gccgccgcga ccggccgggc cgcccgcgag
     4021 ttcgcccgcc cgatgctgcg cgaggagctg gcgcacgccg tcgtcaccgc gctggccgag
     4081 gccggcctgg ccggctggga gctgtcctgg gccgggcccg ccgagcttcg gctgccggac
     4141 gggatcgagg agggcttcga cgcggccctg gacgccgcct gcgccgacac cccggacacc
     4201 gcgccgctgc gcgcgctgct caccggcgcc ggcctccccg cgcccgtcgc ccccgccgtc
     4261 tgaccggccc ggcggaccga ccaccacgcc acggaaggaa cacccttgat cggcatcatc
     4321 gtgctggccg tcgtcggcct cgtcctgctg ttcccggtcg tcatgacccg gctggccaag
     4381 cggaagctgg cccagctgga gcgggccaag gccaccatcg cgaagcacga ggcgcggctc
     4441 gccgaggagg accgggcgaa gcacaccatc gtcccgtccg agcacggact gctgcccgcc
     4501 agcgagatgg tcctggacgg cgagcccggc cccgaggagg ccgccgcgct cgccgccgcc
     4561 aaggccggcg actggcagcc ggccgccgcc cacctcggcg cggacgtctc ggccgacgtg
     4621 cgctggaagc ggcagcgcga gctggcccag ctggcggccg aggacgacac ctggctgcgc
     4681 gcctggcgcg cggagcggcc acaggatccg gtcgccgccc tggtccacgc ggacgccctg
     4741 gtctacctgg cctggaacat ccgcaccggc gcccgggcca gccaggtcac ccgcgagcag
     4801 ttcgagagct tccgccgggt cctgctggag gccgagcagg ccgccgtggc ggccgccgcc
     4861 ctcgcccccg acgacgaccc caacccgtgg gtcgcccaga tccccgtcgc gatgggcctc
     4921 aactggtcca acgaccgctt ccgggagctc tggggcgagc tcaccaagcg cgagccgcac
     4981 cactgggcgg cgcacaaccg ggcgctgcag tactggtgcg acaagtggca cggcagccac
     5041 gagctgatgc acggcttcat cgacgaggcg atcgccgccg caccgcccgg cagcctgctc
     5101 accccgatca agctggaggc ctacttcgag cagttcgccc aggaccggga gaagcccacc
     5161 gcctggaagc ggccggaggt cggcgccgcc ctggacgccg ccctcgccga cctcgcggcc
     5221 gccgacccgg accacccccg gatggagtac acccgcggct ggctcgccta cgccctgacc
     5281 aaggccgggc gcccgaccga ggcgctggag cagtaccgtg cgctcggccg ggtcatcccc
     5341 cagccgttca ccaacttcaa cgacccccgg caggccttca tcggtctgcg ggtcgacgcc
     5401 gtccagggcg ccgtcgcgca ggccgggaag aaggcctgac ccggcgcccg gcggaaaccc
     5461 gtggccccca ctcccgctcg agcggagtgg gggccacggg gcgttcccgg tcagcccgcc
     5521 accgggccga caccggggcc ggcagcgggt ttggccgcgc cgactcgggc tagccgcccg
     5581 gtatgaacgc ctcagctctg cacacccacc gctggtcccg tcggctgcgc cgcgccctgg
     5641 aggcgcccgc gcactgggag gtgctggacg ccccggccgg gccgctcgcc gacgcggtcg
     5701 aggcccttcc gctgggcctg tcccgggacg ccctgcgcgg ggtgtggctg ggccacccgc
     5761 tgcaccccgc gctggtccag ctgccgatcg gctgctggac gtcggcggga ctgctggacc
     5821 tcgcaccggg ccggagccgt tcggccgacg ccctggtggc ggcgggcctg ctgtccgccg
     5881 ggccggccgc gctggcgggc tgggtggact gggcccggct cgacccgccg cggcggcgca
     5941 ccggcctggt gcacgcgctc gccaacaccg gcggcgtgct gctgtacgcc ggatccctac
     6001 tggcccggtg ccgggggcgc cgcggccgcg gccggctgct cggcctggcc gggatggccg
     6061 ccgtgaccac cggcggggtg ctcggcggac acctggccta ccggcaggcc gccgggcccg
     6121 accgggccgc cgcggtcccc cggctggcgc cggcggactg ggccgcgctc ggcgcggtcg
     6181 aggacttccc cgtcgggcag ccggtccgcc gcagggccgg cgaactcgcc gtggtcgtcg
     6241 tgcgcgaggg ggaccgctgc cacgtgctcg cggagcgctg cgcccacctc tccggcccgc
     6301 tctcggaggg caccgtcgtc gacggctgcc tgcgctgccc ctggcacggc agcgagttcc
     6361 ggctgaggga cggcgaggtg gtcagcggcc ccgccaccgc accgcagccg gtactggaga
     6421 cccgggtgct ctcggggcac ctggaggtac ggctgccagg ggccggttga ccggccgtca
     6481 ccggtcgcgt ttcgcccggg cctgacggac acccacccat tggaggtgcc gacaccatga
     6541 cggtcgacac gatcacctcc cggctgctcg ccgagcacgg ccggacgtac gccgaagagg
     6601 ccggcatcac cctgcgggac aagccctcgc cgctgtaccg gctgctggtc ctgaccgtcc
     6661 tgtgctcgat ccggatcagc gccgagaccg ccaccaaggc cgcccgggag ctgtccgccg
     6721 ccgggtaccg cacgccccgc gcgatggccg actccagctg gcaggaccgg gtggacgcgc
     6781 tcggccgggc ccactacgtc cggtacgacg agagcaccgc gaccgcgctc ggcgaagggg
     6841 cggagctcct gctcgaccgc tggcacggcg acctgcgcag gctgcgcgac gaggccgacg
     6901 gcgacccggg ctcgctgcgg gagctgctgc aggaggtccc gcggatcggg ccggtcggcg
     6961 cggacatctt ctgccgggag gtccagacgg tgtggccgtg gctgcgcccg tacttcgacg
     7021 agcgggcgtg cggggcggcc gaggagctcg ggctgccgca caccccgcgc ggtctgggcg
     7081 gcctcgtccc gccgaaggac cacgcccggc tggccgccgc cctggtccgg gtcagcctgt
     7141 ccaagggggc gctggaggaa ctgcaagccg cttgagcgcg agcccgtccg ttccctgacc
     7201 tccccgcggc tccttcagcc gccgggcgct gctcccctcg catgaagccg ccgccgcgtc
     7261 gccacccgga tgcaccacta actgacgatg tgtcaccacc atgggccctt cgggccggac
     7321 cacagcgtcc acggcaaacc ggagaccagg cggagcacat gacgcgactc agttcaccga
     7381 cgcaccggaa agacggagga gtgagaggag ggcggacgct gctccggctg aaggcggggc
     7441 cggcggccgc ggcgggcctg ctgctgctcg gcttcgcgac accggcgcgg gccgtcgaga
     7501 ccaccgtgtc ggtcaacaac aagcgcaccg ggtgggacgc gaacgagccg aacctctccc
     7561 ccgcccaggt gtcctcgtcg aacttcgggc agcgctggtc caccgcggtg aacggcgcgg
     7621 tgctggccca gccgctggtc accggcacga acgtgatcgc ggcgaccgag aacaacgacg
     7681 tcttcggcct cgaccccgcc accgggagga ccaactggag ccggcacctc ggcgcggcgt
     7741 ggcccacctc gaccgtcagc tgcaacgacc ccgccgccca caccgggatc accggcacac
     7801 cggtgtacga cccgtcgtcc aacaccgtct acctcaccag caaggtcaac gacggccccg
     7861 acgtcgacca cccgcactgg tacatgcacg cgctggacgc ctccaccggc gccgagcgaa
     7921 cgggctggcc ggtgaccatc cagggcacgc cgaccaacag cccgggccac ccgttcaacg
     7981 ccaagaccgc cgcgcagcgc cccggtctgc tgctgatgaa cggctccgtg tacgcggcct
     8041 tcgcctccta ctgcgacacc ggcccgtacg tcggccaggt cgtcggcgtg aacgcctcca
     8101 cccgcaaggt caccctgtgg tccaccgagg ccggctccga ctccatggag gccggcatct
     8161 ggcagagcgg cggcgggctg gtctcggacg gctccggccg gatcttcctc gccaccggca
     8221 acggagccgg cacgggcgcc tcgccgagcc ccggccccgg caaccggcct cccgggcacc
     8281 tcggtgagtc ggtggtccgg ctgggtgtga acagcgacgg cagcctcagc gccagggact
     8341 tcttcagccc caccgacaac cggaccttgg acaagaacga caccgatctc ggctccggcg
     8401 gcccgatggc gctgccgtcc ggtttcggca ccgccgcgca tccgcacctg ctggtccagg
     8461 tcggcaagga cggccgggtc ttcctgctgg accgggacaa cctcggcggc atgggccagg
     8521 gcccgaacgg caccgacaac ccggtcagca tggccggccc cttcgagggc gtctggggcc
     8581 acccctccgt cttcggcggt ggcggcggct acgtctacac ggtggccacc gacaccggca
     8641 acggccgctc cccgctgcgc gcgctcaagt acagcgtgaa cggcgccggt gtcccggtcc
     8701 tgagcagcat cggcaccagc aacgagggct tcggctacgg ctccgggtcc ccggcggtca
     8761 cctcctacgg gccgaacccc aagtccgcgc tggtctgggc ggtgtggtcc ggctccggtg
     8821 cgggcggcgt cggcggcgag ctgcgggtct acgacgcggt gcccgtcaac ggcgtcatgc
     8881 acctgcgccg ctccttcccg atcggcacgg cggccaagtt cgtggtcccc gcgaccgacg
     8941 acggccgggt cttcgtcggg accagggacg gccacctggt ggccttcggc agccagtaga
     9001 gcgcccacgc gaaccggggt gtgcccgacc gctcggcggt cgggcacatc cgtgtccggt
     9061 cgggtcagag ttcgatcagc atgccgtcct cggcgaccgc ggcgaccgcc gccgccagat
     9121 ccgccgcccg gggcgggtcg cgacgggcga gcgggttggt gttgttgagg tgggtgtaga
     9181 ggtagcgggg gccgggtcgg cgggcgaggt gcgggagcga gtcccgcacc gcgaggtggc
     9241 ccatgccggg cgagcggcgg gcgccgccgg tccgctcggc gagttcgtcg gccgtggaga
     9301 aggtgccgtc gagcaggacc aggtccgccc cggccaccgc gcggtccatg gccggcgtcc
     9361 actcggccag ccccggggcg tacacggcgc acgcggcgcc gtccgccgcg gtgaaccggt
     9421 agccggtcac ccagtccgta cggtccggcc ggccctcgcc gggtaggtcg gccgcgtagc
     9481 gggggcgctt gccgccgagc gcgaaggctt ccgcgcgcag cccgccggcg agctccacgg
     9541 gctcgcccgg ggtgacggtg tgccagtggg atccggtgta ggacgcgagc aacgggccca
     9601 cggggaaggc ctggtggagc gcgcggcgca ccggctcggt ggcgtgcacg gtcagccggt
     9661 cggcctcgcg cagggtcagc aggcccaggg tgtggtcgag ttcgccgctg gtcagcagga
     9721 cgccgcgcag cggggtgtcc cgggtgcccg gggcgggggc gagttcgggt gccgcgagca
     9781 gctgggtccg caggtccggg gaggcgttga ccaggtacca ggcccggccg tcgccgctga
     9841 ccgccaggca gtcctggctg cgttcggcac cgctgcggcg ggcggcggcg cactcggcgc
     9901 agccgcagtt ccactgcggc aggccgccgc ccgcggcggt cccgaggacc ctgatcttca
     9961 cctgattcct cccgtactcg ggcttcggcg ggaggggcct tcagcggtag cgccggggca
    10021 ccggggtcgg cgtctcggcc gggaccggct cggtgaccag gtggcggtgc ggcgagagcc
    10081 ggcaggccgg gtcggtcacc gccggatcgc cggtgaactg gtaggcctgg cagcggcagc
    10141 cgccgtggtc caactcgcgc agggcgcagc tgcggcacgg ctccggcatc cagtcggtgc
    10201 cccggaaccg gttgaacgcg ggcgagtcgt gccagctcgc cgcgagtccg tcggtgaccg
    10261 cgttggggac cgtcaggccg ggcagctgcg cggcggcgag gcagggcagg acgtcgccgt
    10321 tgggggcgac cgccagctgc tcgcgtcccc agccgttcat gcagggcttg acggtgccgc
    10381 cgtgcaggtc ggcggggacg tacccgatct cgacccgctc accgtggcgc tcccgggcgg
    10441 cggcgacgtc ccgttcggcc tgccggacct gctcctcgtc gggggcgagg tgggcgcggt
    10501 tgcgccaggc ccagccgtag tactggacgt gggcgagctc gacccggtcg gcgcccagtt
    10561 cgaccgcctg gtcggcgagg gcgccgagcc gggccaggtt gccgcggtgc agcacggcgt
    10621 tgacggtcag cggcaggccg gcggaggtga actgccgggc cgcggcgagc ttgcggtcgt
    10681 gggcggcgat ccccgcgatg gcgtcggcgc tgcgcggctc ggcgtcctgg agcgagagct
    10741 gcacgtggtc gaggcccgcc gcggcgagtt cctcggcgcg cccgggggcg agcgggacgc
    10801 cgctggtgat caggttggtg tagaggccca actccgcagc gtgagcgatg agttgcgtca
    10861 ggtcgcggcg cagcagcggt tcgccgccgg tcaggtgcag ctggagcacg ccgagcccgc
    10921 gggcctgctc gaggacccgc agccactgcc cggtgtccaa ctccgcgcgg tagcgggaga
    10981 gttcgaccgg gttggcgcag taggcgcact ggagcgggca gcggtaggtg agttcggcga
    11041 tcagtccgag cggggcgggt gcgcggaccg cgccgccggg aggtgcggcg gccgtcgcgg
    11101 gccggacggg ggcgccggtg ccgtccaggg tgagcagccg gcgctcgacg agttcggcga
    11161 gcagggcgtc gacctgggcg ccgtccaccc cgtcgtactc ctcggcgagc cgggcggcga
    11221 gcgatcgcgc gtcgcggcgc ccgtcgcagt gccgcaggac ggcggcggcg gtgtcgttga
    11281 gcagcagcac gccctcgggg tggagcagcg cggaccggcc gcgcgccggg tcgtgcacca
    11341 gccggacgcc cgcgcgcagt ccggggacgg gatcggccgg ggcggtgggg acggccgggg
    11401 cggtgctcat cggtcggctc cgtagtcgac ggcgtccagc atggcccgta gcacctcgca
    11461 cttgaaggcc agcgcgtcca cggcggcctg ctgctgggcc tcggtgacgc agtggtccag
    11521 gacgagttcc agggtgcggg cgctgtcctg gcgggcgacc gggatgcggt gctcgaagta
    11581 ggcgtagccg gccgggtcga tccagcggta gtgctcgcgc caggcggtga cgcggtcggc
    11641 catgtggtcg ggcgagaaca tctcggtgag cgccgccgcc gctccctcgg tccagggccg
    11701 ggtctggcag aagtgcaggt agccgtcgac ggcgaaacgc accccgcggg cgacgtgccg
    11761 ctcgtcgagg acctctgtgc ggtccaggcc gaccgcctcg gcgagcacca gccagtcggc
    11821 gaggccgccc tcggctccgg gcccgtcctg ggcggggccg tcgtgatgga gcccgtcctg
    11881 gtaggcaagc cggccggccc aggcccgacg gacctccggg agcgggcagt tggcgatgat
    11941 cgcggcgttc ttgcgggtca ggcagagctg gtagtaccag cggttggcga cccagcgccg
    12001 cagctccggt ggtgtgcagc caccggagtg caggcgcagg tggaacgggt gggtgtccca
    12061 gtaccgtccg cgcaggtcgt acagcctggc cgcgaactgc tcgcggctca gcggtcgcgc
    12121 cactgcgggg cccggccggc gtaggcggtg acctcggcgc cggtgcggtg gcactccacc
    12181 gcgggtgcgg accaggcggg cctggtgccc accggccggg ccgtgggtgc ggcggtggct
    12241 ctcggcggcg gtgtcggggt acgagcggca tccatggctg cctcctcggt tcggggatcc
    12301 ggttcgggga tccggttccg ggtccgattc ggggtccgat tcggggtccg aatcggggcc
    12361 ggagagggca cacgccctct gcggggacgc tacgagcccg cacgggtggg cgccggtcga
    12421 gaaccgcgcg gaggcggtgt cggacgccca cgaacggggg tccgcggtgc gctgccgggc
    12481 ccgctcccgc ccggtcggag ccgggcttcg gggggaccgg cacgcggttc acccggtcga
    12541 gtgacgccag agcgcgccac gggcggaagg cgccgaccgt ggccgggccg gaatcgccct
    12601 cggcggaccg cgcgggccgt cccggcggag ccacacctgc acgtggcgga ggtggagcgg
    12661 ggtcacgggt tcacccgggc gcagggcccg cggggcccat cggcgggctg acggcggtca
    12721 tggtgccggg ggtgacagct gtcatgcccg atcggtgacg gagcgacctg ccgcccgggg
    12781 gccgggattg gcgaagctga cggtgcatca atcgaacgca cacccagggg agagagcacc
    12841 atgacgaagc ggatcctggc cctggccatc ggcgtggctg tcctcgccgg acgggctgtg
    12901 gccccggtgg cggaggccgc ggcacccggc ccggcgatgg cgacggtcac cgtcgacggg
    12961 cgggtcacca acaccgtccc ggccgacgcg atcggggtca acaccccgtt ctggagcgcc
    13021 cagttcaccc gtagcgacac cccgaggcgg atccgcgagg cgggcatcgg cactctgtcg
    13081 ttcaacgccg gcggagcggg cgacctctac cacttcgacc acggcggctg gctcagcccg
    13141 gacccgtacg gcccgtacaa cggcccgggc ggctacggct accagaacct gaccccgcgg
    13201 ttctccttcg accgcttcgc ccggacggcg cgggccgcgg gcgccgggat gctggtgcac
    13261 gtcaactacg ggaccgggcc gggcgacacc gccgaccacc cgagcaccga cgccgacccc
    13321 aagcccgggg atccgcagga ggccgccgac tgggtgcgct acgcgaacgt gacccggggc
    13381 tacggcgtcc gggactgggt gatcggcgag gaggtctacc tcaacggctg gaacaagccc
    13441 gccgggccga ccccgcccgg gccgggccac gacctcgagg tccgcgagcc ggacgcgcac
    13501 gcggaccgga gcccggcggc gtacgcgcgc aacagcatcg agtacgcgaa ggccatgaag
    13561 gccgtcgacc cgggcatccg cgtcggcatc gaactgttcc cgtacgaccc gcagcggctc
    13621 ggtgcgcccg ggcccgacgc ccgcgccaag gagtgggacg aggcggtgct cggcaccccc
    13681 ggactggccg cggcggtcga cttcgtcgac gtgcactggt accacgcgca cttcgccggg
    13741 gtcaccacgg aggcagagct gctcgccgac acctcggcca ccgcccgcgc catggccacc
    13801 gtgcgcacgg ccctcgaccg cgcctcggga ccggaccacc ggatcgacgt catcgcgggc
    13861 gagaccaacc tcgacaacgt gggcaacccg caccagcgca ccaccgcggg cgcgctctac
    13921 ctgctggaca gcaacctgtc gctgctggag aacggcgtct cccaggtcga ctggtgggcc
    13981 ctctacaacg gcccggggct gttcgggaag gacggcaagg actgggggga cctcgggctg
    14041 ctgtcctccg gcgagtgccc ggccgactgg tccggcgccg atccgtgcga gcccccggcc
    14101 gggacgccgt tcgcgccgtt ccacaccatg aagctgctga ccaccgcgct ccggggcggc
    14161 ggggacaccc tggccgccac cacggacaac cccgcgctcg gcgtgcacgc cgtccggcgg
    14221 gccgacggga cgctggccgt ggtcctggtc aacaaggacc cggagcacgc ccagccgttc
    14281 cgcctcgacc tgcccggcga ctaccgggtg cggcgcaccc tcgcctggca cgacggcgac
    14341 gacgcgccga cggtccggca cggctcggcg ccgagcacgc tcgcgccgta ctcggccgcg
    14401 gtcatcctgc tcgacccgcg cgactgacga tcacgagagg aaacagcaca tgaaggtgtt
    14461 ggtcgccggg gccgggatcg gtgggctctg cctggcccag gggctggtcc gggcggggat
    14521 cgacgtccgg gtcttcgagc gggagcccgg tccggacagc cgctatcagg gcttccggat
    14581 cgggctggac gaaccggggt tggctgctct gcgggagtgc ctgccgcacc ggctgcacgg
    14641 cctgctggag gccgtgaccg gcccgctcgc gggcgagcgg cgggtggtgg accagcaact
    14701 gaacgaggtc cgccggctcg gcgcggcgtc cgggggcacg gccgccgacc ggcacgtgct
    14761 gcggcagctg ctgctcgccg ggctgggcga ccgggtggag ttcggccggg ccgtggccgg
    14821 gtaccaacag cgggcggacg gccgggtcga ggcccggctc acggacggtg gcagcgcggt
    14881 cggtgacctc ctggtggggg cggacggcgt gggctcggcg gtgcggcggc agctgctgcc
    14941 cggggccgag gtcaccgctc tccccggcaa cgcgctgctc gggcgcaccc cgctgaccga
    15001 gcctctctcg ggcctggtac cgggcgcggg cacgctggtg cgcggcgcgg acctgagcct
    15061 gctgatcggc cggatggagt tccggcggcc accgcggctc gcggcggccg agctggcgcc
    15121 ggaggtggaa ctgccggacg cgcacagcta cttgcgctgg gtggcgatgc tccccgagcc
    15181 gctctcgccc gagcccggcg cctgggcgga ggtgcgcgac cggctgctcg agctgttcga
    15241 cggctggcac cccgatctgg tcgagctcgt ccggcggtcc gacgtcggca acagctcgcc
    15301 gttgacgatc cgctacgccg agcccgtacc ccactggggc accgggccgg tcaccctgct
    15361 cggcgacgcg atccacgcca tgccgccgag cgccggccag ggcgccaaca cggcgttccg
    15421 cgacgccgcg ctgctctgcc gctcgctcac ggccgtccac cgcggcgagg ccgaactggc
    15481 cgccgccgtc gaggagtacg agctgcggat gctcgagcgc ggcttcgcgg cggtcgccga
    15541 gggcctggcc cggctcgcgg agttcacacc ggcgcgctga aacgcctcag cccgcggcgc
    15601 agccccggcg cgcgctgaag cgcctcagca cgcgctccag cacacggcgc agtctccggc
    15661 ctgggcaggg cagcgggcag cccgggcgcc gcgaccgaca ccgggccagc ggcggccggg
    15721 cggtggtgga ccggccgccg gacggcgcgc gaaggacggc ggcagctgcc gagcccgacg
    15781 gcctccgccc agccggtcct cgcccggtca gtcctcgccg aggacggcgt aggtctccgc
    15841 atcgccctgc tccctgctct cgtcgtccgg tgcgcccgac gggcgggagc atgccggtcc
    15901 gccgacatcg gaccgggccg gcgggcggac ggcctcggcc ggaccgcctt cgcaccgtcc
    15961 atggtggtca cctccggtga tcgggcgccc tgccgggcgc cggggggacc ccaccgactg
    16021 cccggcgccg caagccgcga acggcggacg tccaccggac ggatggcgtc gaggtttcgc
    16081 cgcgcccggc ccggttagcc gctcgacgga ggaacccgag gagcccatcg aggaaccgag
    16141 gctgccatga ccaccgcgtt cggctacttc ctgtcctgcg aggagttcac ccccacccag
    16201 ctggtcgagc aggccgagct cgccgagcgg gccggcttca cccggctggc gatctccgac
    16261 cactaccacc cgtggaacga cgcccagggc agcagcccgt tcgtctgggg cgtgatcggc
    16321 gcgctctccc gggtcacccg gctgccggtg accaccctcg tcacctgccc gaccgtgcgg
    16381 ctccaccccg cggtaacggc ccaggcggcg gccaccgcgg acgtgcagct gcccggcggc
    16441 ctgcggctgg gcgtgggcac cggcgaggcg ctcaacgagc acgtcctggg cgaccgctgg
    16501 ccgccgttcg acgtccgggc ggagatgctc gaggaggccg tcgcggtgat gcgcgagctg
    16561 ttcaccggca gcctcgtctc gcaccgcggc acccactaca ccgtcgagaa cgcccggctc
    16621 tacaccccgc cgaaggacgg ccggctgccc gtctacgtct cggcgttcgg ccccaaggcg
    16681 gccgaatcgg cggcggagta cgcggacggg ctggtcacca tgagccccga caccgagctg
    16741 atcgggcgct accgcgcggc gggcggcacc gggccggtga tcggcgggct gaaggtgtgc
    16801 tggtcaccgg accgcgagcg cgcggtcaag accgtccacc ggctctggcc gagcgagctg
    16861 ctgcccggcg aactcgccca ggtcctgccc accccacggc acttcgagca ggccaccgaa
    16921 ctggtcacgg aggagatgac cgcccggtcg gtcacctgcg gcgacaaccc gcaggagcac
    16981 gccgaccggc tgcgcggcta cgtcggcgcg ggcttcgacg aggtgtacgt cggccagatc
    17041 ggcccggagc aggccgggtt cttcgacttc taccgcgagc agatcctgcc ccgggtggct
    17101 taggactcgg gagcacaccc catgacggcc ttcccgcccc gcagcctgcg cgagtacgcc
    17161 ctgctcgccg acggcgaacg cggcgcgctg gtcggcccgt ccggcgagat cgcctggctc
    17221 tgcgcgcccc ggtgggactc cgacccggtg ttcgccgcac tgatcggcgg caccggcgag
    17281 tacgcggtga ccccggtcgg ccggttcgtc cccggcggct actacgaggg ccgcgggctg
    17341 gtccggcacg gccggtggat caccgagcag ggcgtgatcg tgtgccggga ggccctcgcg
    17401 ctgcccgccg atccgcaccg gctggtgctg ctgcgccgcg tccacgccga ctacggcccg
    17461 gcccgcctgc ggctgcgact ggcggccggc agcggcttcg acacggcccg cacccgcgct
    17521 ccgcgccgga cgacggacgg ctggtcgatc cgcgccgggc ggctgcggct gcgctggacg
    17581 ggcgcccagg cggcccggcc ccacccggac gggagcctcg tggcggacgt cgccctcgac
    17641 ccgggcgaac ggctggacct cgtcctggag gtgtccgacc ggggcctgga cgcgccgccg
    17701 ccggaccccg accggtgctg gcgggccacc gaacgcgcct ggcgagccgc cgtaccggac
    17761 ctccggcaca cctacgacgg acgcgacgcc gccttctcct acgccgtgct gcgcggcctc
    17821 acctcccccg ccaccggcgg gatggtggcc gcggcgacca ccagcctgcc cgaacgggcc
    17881 gaggagggcc gcaactacga ctaccgctac gtgtggatcc gtgaccagtg cctggccggg
    17941 caggccgtcg ccgcctgcgg gcccgacccg ctcctggacg acgccgtacg gttcaccacc
    18001 gcgcggctcg cggaggacgg gccgcggatc gcccccgcct acaccgcggc cggcgggcga
    18061 gtacccgacc agcacaccgt cgacctgccc gggtacccgg gcggccacga ccaggtcggc
    18121 aaccggatca cccggcagtt ccaactggac gcgttcggcg aggccctgct gctgttcgcg
    18181 gccgccgccc ggcacgaccg cctgggcccg gaggcccacg gcgcggcccg gaccgcggcc
    18241 gccgcgatcg ccgcccggtg gcgtgaaccg gacgccggca tctgggagtt gggcccccgg
    18301 cagtggaccc acagccggct aatctgcgcc gccgggctgc acgcgatcac ccggccccgg
    18361 gtcgccggag cggccggcct gacggacggg ctcgcggccg agtggagcgc gctggccgac
    18421 cggctgtccg cccgcgccgc ccgtctcgcg ctgcacccct cgggccgctg gcagcgctcc
    18481 cccgacgacc cggcacccga cctggccctg ctgctgccgc cggtgcgcgg ctggccgccc
    18541 gccgacgacc cgcgcaccgt cgccaccctg cgggcctgcc gcgaacagct caccgacggg
    18601 cactacgcct accgcttccg gcacgacgag cgcccgctgg ccgaggccga gggcgcgttc
    18661 gtgctgtgcg gcttcctgat ggccctcgcc gagcgccagc agggcgacgc cgtcgaggcg
    18721 gcccgctggt tcgagaccac ccgcgggctc tgcggctcgg ccggactgtt ctccgaggag
    18781 tacgacatcg cccagcgcca gcagcgcggc aacctgccgc aggccttcgt gcacgccatg
    18841 ctgctggagt gcgcggcccg gctggccgag ccgccggtca gctgacctgc gggtgcagcc
    18901 ggtagacggc gaaggcgcgg ccgatgacgg gctgggcgac gttgcgcacc cgcaccccgc
    18961 aggcggtcag gccgcgctcg gtgcccaggt gcgcgtggcc gtgcacggcc aggtcggcgc
    19021 cggctccgtc gatcgcctcg gcgagcaggt agctgcccag gaacgggtgg atctccggcg
    19081 gctccccggc cagggtgtcc gggacggggg cgaagtgggt cagggcgatc cgcaggtcgc
    19141 agccctcggc ggccagctgg tcgagggcgg tgcgcaggcc gtcggcgcac tcgcggctgt
    19201 gccggacgaa ggccttcatc tcgggctcgc cgaactcgcc ggcactgcgg ccggcgaagc
    19261 caccgccgaa gcccttggtg ccggccaccc cgaccagcag gccgtccacc cggacggcgg
    19321 tcgagctgcg ttccagcacc tggacgccgt acgcggccag gatccgggtg acctcccccg
    19381 gtcggtcggc gtcgtagtcg tggttgccga ggaccgcgat caccggcacg ggcagcccgc
    19441 cgacctcctc ccccaccacc gcggcctcct cgacggtgcc gtgccgggtg aggtccccgg
    19501 ccagcagcag cacgtccgcc agctccccca gggtggcgaa ggcgggccgc agcagacccc
    19561 ggctgtcggg gccgagatgg atgtccccga ccgcggccac ccggatcacg gcaggtcctc
    19621 cgctccgctc ggcggccggc cgtcggccag cgcgatgtcg gtgtgcaccg tcagtccgtc
    19681 cagcacctcg gccacgatgc gctcgactgc ggcgcggcgc tgctcgttcg gtacggtgcc
    19741 gcgcaccgtg acgtgggtgc cgtgcagttc gatccgcagg ccgagctcgc cgacctcgtc
    19801 gtcggcgagg cggtcgcgca ggtgggccag ccggtactcg gtgtcgtcgg cgtcggtcat
    19861 cgggcggcct cctcgggttc gatcacctgg agccgctcca ggaggtacag gaacgcggcc
    19921 gccatcggct gctgcccgcg ctccgcccgc acccgccgcc agtcgatctt ctcccgcagc
    19981 ggccgcacca ccgagagcgc cgccccgaag tcgcagtggt gctcggagaa ggcggccagc
    20041 aggccgctga ccaggtcggt ggcggacagc accggcatct gcacggagtc caccggcagc
    20101 acctcggcgc ggtccagcag gtccgaggtg accggccgtt tggccagctc caggatcagg
    20161 tcgatgtcct ggcccaggca gcgggccttg atcagccagt cctcgggcgg caggaacacc
    20221 tggagcccgg cctcgcgcag ggtgtgggtg atggcctcgg cgtcctcgcg gcggatgcag
    20281 aagtcggcgt cgtgctggag ccgcacatcg gcgccgtggg cgtaggcggc gaccccgccg
    20341 gccagcgcga acgggtggtc cttggccttg agcagcgagc cgatccgctt cgtcgcctcc
    20401 aggatcgcct gcgcccggtc gggcggcagg ctgcctccgg cgtcgtcggg cggccagccg
    20461 cccggctcgg gccgcgccga gcgggacgca tcggggtgtt cggcgcgtcg gtccatcgcg
    20521 gcctcctccg cggggtccgt tcggacgccc ccacgggtac cccgcccacg cgagttcact
    20581 ccggcggatg ggggtccgga cgcgctggag cagatccggc ggaggctgga acggacgggc
    20641 agaggggtcc ggccgggctc gacgccgcag gccccggcca ggccggcgga cggacggtgc
    20701 cgtggacctc gatcagccgc agttcggtgg tcatggcccc gaagcctccg cccggtgtgc
    20761 ctccaccgcc cggcggacct cggagacggc acgcggcacc gcgtcggtga cggccgggct
    20821 caggccctcg ccgatcgaga agtccgcacc ctcgaccgcg acgatcagca gctcgcgcgg
    20881 cagtctgccc aacgcggcgg ccagcgcgac accgtggccg aggcccaggc cgtgcgtgcc
    20941 cgccggcgac tcctcgtcca cgagcgggtc ggcgagcagg tggtcggcat cgacggtgac
    21001 cgagtggatc cggcccggtt cgcccgggtg gccgtgcacc gcgtcgacca cgatggcgag
    21061 gccggcgtcc tcccagagtt ccatcagccg ggtgggctcg ccgtcgcaga gcgtgagccg
    21121 gtcgacggcg aggtcctcgg cggcgagctg cgccaggacg gacacggcgg cgccgtcgtc
    21181 gtggcggtac tcgttgccga ctccgatgac gacgatgcgc tcgttgccca tgcccgtcac
    21241 ctccggtcca tggtgagcgt gaggaagtgc gccgcgcagg agatgcacgg gtcgtagttg
    21301 cggatcgcct gctcgcaccg gcgggtcaac tcggcgtcgt cgaggtgcag tcggggctgg
    21361 atgaaggccc gcaggtcgac ctcgatcgcg ttctggttct gcgcggtcgg cgggacgatc
    21421 acggccttcc ggacgattcc ggcctcgtcc aggtcgtacc ggtggtagag cagcccgcgc
    21481 ggggcctcgg tgacgccgaa gccagtggcc gcccggggcg ggacggggac ggccggggtg
    21541 ggcggcggct ggtaccgctc gatgatccgc tgcgcctcgg tgacggccca cagcacctcg
    21601 gccgcgcgga ccacgatgct gcggaagggg ttgtcgcagc gcgggccgag cccgacctgg
    21661 gcggccaggg cacggatctc ggcgggcagg cgttcgctgc ctaggttcca gcgggcgagc
    21721 ggcccggcga ggtgggggcg gccgtcgagc gtcgcgtgca gggcggtgga gtgcggcacc
    21781 tggtgctccc ggacgtgctg ctcgaagtcc cgtacgggga agggaccggc gagggcgccg
    21841 gtcgggacgc cggagtcgat ggcgtagccg tcgggttcgg tgagggcgag cagttcgtga
    21901 ctgatcgcca ggtcggggaa ctcgaacccg gcgacccagc cgagcgtgtc ctcggcgtcc
    21961 gtccgcgcct ggcgcaatac catggccagg tggtcgagtt cggcgcgcgt gggcagtcgg
    22021 tggaagccgc cgaggcggac gttcaccggg tggatgaccc gcccgccgag gacctcgacg
    22081 atctcgttgc cggccttctt cagccgcagc ccgcgctgga gga
//
